Difference between revisions of "Phosphatase Family CDC25"

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_Rhodanese|Fold CC3 (Rhondanese)]]: [[Phosphatase_Superfamily_CC3|Superfamily CC3 (Rhondanese)]]: [[Phosphatase_Family_CDC25|Family CDC25]]
 
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_Rhodanese|Fold CC3 (Rhondanese)]]: [[Phosphatase_Superfamily_CC3|Superfamily CC3 (Rhondanese)]]: [[Phosphatase_Family_CDC25|Family CDC25]]
  
CDC25 is the only CC2 superfamily family with protein phosphatase activity. It consists of two subfamilies, '''[[Phosphatase_Subfamily_CDC25|CDC25]]''' and '''[[Phosphatase_Subfamily_Acr2|Acr2]]'''. CDC25 is is an important phosphatase of cyclin-dependent kinases ([http://kinase.com/wiki/index.php/Kinase_Family_CDK CDKs]), the function role of Acr2 is controversial.  
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CDC25 is the only CC3 superfamily family with protein phosphatase activity. It consists of two subfamilies, '''[[Phosphatase_Subfamily_CDC25|CDC25]]''' and '''[[Phosphatase_Subfamily_Acr2|Acr2]]'''. CDC25 is is an important phosphatase of cyclin-dependent kinases ([http://kinase.com/wiki/index.php/Kinase_Family_CDK CDKs]), the function role of Acr2 is uncertain: it has arsenate reductase activity but may also be a protein phosphatase.
  
CDC25 and Acr2 are found in a mostly mutually exclusive manner across eukaryotes. CDC25 is found in most animals, but is absent from land plants and green alga ''Chlamydomonas''. On the other hand, Acr2 is found in most plants and Chalmydomonas, but is absent from animals and green alga ''Ostreococcus''. However, in fungi and amoebozoans, both CDC25 and Acr2 are present.
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CDC25 and Acr2 are found in a largely exclusive clades. CDC25 is found in most animals, but is absent from plants, while Acr2 is found in plants but not animals. Most fungi and many protists have both.

Revision as of 23:04, 22 August 2015

Phosphatase Classification: Fold CC3 (Rhondanese): Superfamily CC3 (Rhondanese): Family CDC25

CDC25 is the only CC3 superfamily family with protein phosphatase activity. It consists of two subfamilies, CDC25 and Acr2. CDC25 is is an important phosphatase of cyclin-dependent kinases (CDKs), the function role of Acr2 is uncertain: it has arsenate reductase activity but may also be a protein phosphatase.

CDC25 and Acr2 are found in a largely exclusive clades. CDC25 is found in most animals, but is absent from plants, while Acr2 is found in plants but not animals. Most fungi and many protists have both.