Phosphatase Family CDC25

Phosphatase Classification: Superfamily Cys-based III (Rhondanese): Family CDC25

Family CDC25 is the only family of Cys-based II superfamily that have protein phosphatase activity. It consists of two subfamilies, CDC25 and Acr2. While CDC25 is generally regarded as phosphatase of cyclin-dependent kinases (CDKs), the function role of Acr2 is controversial.

CDC25 and Acr2 are found in a mostly mutually exclusive manner across eukaryotes. CDC25 is found in most animals, but is absent from land plants and green alga Chlamydomonas. On the other hand, Acr2 is found in most plants and green alga Chalmydomonas, but is absent from animals and green alga Ostreococcus. However, in fungi and amoebozoans, both CDC25 and Acr2 are present.