Difference between revisions of "Phosphatase Family HP1"
From PhosphataseWiki
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======[[Phosphatase_Subfamily_TIGAR|TIGAR]]====== | ======[[Phosphatase_Subfamily_TIGAR|TIGAR]]====== | ||
| + | Vertebrate TIGAR functions as a fructose- 2,6-bisphosphatase, which results in an inhibition of glycolysis and an overall decrease in intracellular reactive oxygen species (ROS) levels. TIGAR is also found in some basal eumetazoan, but is absent from nematodes and arthropoda. | ||
======[[Phosphatase_Subfamily_STS|STS]] (TULA or UBASH3) ====== | ======[[Phosphatase_Subfamily_STS|STS]] (TULA or UBASH3) ====== | ||
Revision as of 22:25, 3 January 2015
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): HP, branch1 family
Contents
Subfamilies
PGAM
PGAM5
PGAM5 is a protein phosphatase conserved in metazoan. It has distinct substrates.
TIGAR
Vertebrate TIGAR functions as a fructose- 2,6-bisphosphatase, which results in an inhibition of glycolysis and an overall decrease in intracellular reactive oxygen species (ROS) levels. TIGAR is also found in some basal eumetazoan, but is absent from nematodes and arthropoda.
STS (TULA or UBASH3)
STS is protein tyrosine phosphatase involved in T-cell receptor signaling. In particular, STS dephosphorylates kinases Syk and ZAP-70 of Syk subfamily. STS is conserved in metazoan.
