Difference between revisions of "Phosphatase Family LMWPTP"
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Revision as of 18:08, 14 March 2014
Contents
Phosphatase Classification: LMWPTP
Function
In eukaryotes, LMWPTP dephosphorylate many receptor tyrosine kianses, such as platelet-derived growth factor receptor (PDGFR), insulin receptor (InsR), or ephrin receptor (Eph) [1].
In prokaryotes, the molecular function is not fully understood. It is involved in the syntheisis and translocation of exopolysaccharides (EPS) and capsular polysaccharides (CPS) in E. coli.
Evolution
The LMWPTP is present not only in eukaryotes but also prokaryotes. In eukaryotes, it is generally absent from alveolates, trypanosoma, leishmania.
Comparison of the catalytic site with LMW-PTP
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LMW-PTP
Ssu72
Sequence logo of catalytic site of Ssu72 and LMW-PTP. The logo of Ssu72 was built from 33 sequences, and that of LMW-PTP from 42 sequences including five known prokaryotic LMW-PTPs.