Phosphatase Family MDP1

Phosphatase Classification: Superfamily HAD: Family MDP1

MDP1 is the only human member of this family. It has been reported as a putative tyrosine phosphatase [1]. However, a later study reported that it is a protein-fructosamine-6-phosphatase potentially involved in glycation repair [2].

References

1. Peisach E, Selengut JD, Dunaway-Mariano D, and Allen KN. X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily. Biochemistry. 2004 Oct 12;43(40):12770-9. DOI:10.1021/bi0490688 |
2. Fortpied J, Maliekal P, Vertommen D, and Van Schaftingen E. Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair. J Biol Chem. 2006 Jul 7;281(27):18378-85. DOI:10.1074/jbc.M513208200 |