Phosphatase Family OCA

Phosphatase Classification: Superfamily Cys-based I: OCA

OCA is found in most if not all of fungi, plants, protists (chromalveolata, excavata), as well as monosiga and sponge. The family is named after yeast phosphatases OCA1, OCA2, OCA3, OCA4, OCA6. OCA is short for Oxidant-induced Cell-cycle Arrest. It is also known as plant and fungi atypical (PFA)-DSPs [1, 2].

Reference

1. Romá-Mateo C, Ríos P, Tabernero L, Attwood TK, and Pulido R. A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity. J Mol Biol. 2007 Dec 7;374(4):899-909. DOI:10.1016/j.jmb.2007.10.008 |
2. Romá-Mateo C, Sacristán-Reviriego A, Beresford NJ, Caparrós-Martín JA, Culiáñez-Macià FA, Martín H, Molina M, Tabernero L, and Pulido R. Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms. Mol Genet Genomics. 2011 Apr;285(4):341-54. DOI:10.1007/s00438-011-0611-6 |