Difference between revisions of "Phosphatase Family SSU72"
From PhosphataseWiki
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC2|Superfamily CC2]]: [[Phosphatase_Family_SSU72|Family SSU72]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC2|Superfamily CC2]]: [[Phosphatase_Family_SSU72|Family SSU72]] | ||
| + | ====Evolution==== | ||
Ssu72 can be found in all the unikonts (animals, choanoflagellates, fungi, and amoebozoan), plants/algae, Heterokonts, Trichomonas vaginalis (but not Giardia or Trypanasoma or Leishmania). Most SSU72 consist almost entirely of the phosphatase domain. | Ssu72 can be found in all the unikonts (animals, choanoflagellates, fungi, and amoebozoan), plants/algae, Heterokonts, Trichomonas vaginalis (but not Giardia or Trypanasoma or Leishmania). Most SSU72 consist almost entirely of the phosphatase domain. | ||
| + | ====Function==== | ||
The phosphatase activity of Ssu72 is important for Pol II transcription and termination and for gene looping. It catalyzes CTD Serine-5 dephosphorylation in association with the Pta1 component of the CPF complex. In yeast, Ssu72 is required for pre-mRNA 3’-end cleavage, but so far no evidence exists implicating mammalian Ssu72 in that processing <cite>Krish04</cite> <cite>Xiang10</cite>. | The phosphatase activity of Ssu72 is important for Pol II transcription and termination and for gene looping. It catalyzes CTD Serine-5 dephosphorylation in association with the Pta1 component of the CPF complex. In yeast, Ssu72 is required for pre-mRNA 3’-end cleavage, but so far no evidence exists implicating mammalian Ssu72 in that processing <cite>Krish04</cite> <cite>Xiang10</cite>. | ||
| − | == Reference == | + | ==== Reference ==== |
<biblio> | <biblio> | ||
#Krish04 pmid=15125841 | #Krish04 pmid=15125841 | ||
#Xiang10 pmid=20861839 | #Xiang10 pmid=20861839 | ||
</biblio> | </biblio> | ||
Revision as of 18:14, 12 November 2016
Phosphatase Classification: Superfamily CC2: Family SSU72
Evolution
Ssu72 can be found in all the unikonts (animals, choanoflagellates, fungi, and amoebozoan), plants/algae, Heterokonts, Trichomonas vaginalis (but not Giardia or Trypanasoma or Leishmania). Most SSU72 consist almost entirely of the phosphatase domain.
Function
The phosphatase activity of Ssu72 is important for Pol II transcription and termination and for gene looping. It catalyzes CTD Serine-5 dephosphorylation in association with the Pta1 component of the CPF complex. In yeast, Ssu72 is required for pre-mRNA 3’-end cleavage, but so far no evidence exists implicating mammalian Ssu72 in that processing [1] [2].
Reference
- Krishnamurthy S, He X, Reyes-Reyes M, Moore C, and Hampsey M. Ssu72 Is an RNA polymerase II CTD phosphatase. Mol Cell. 2004 May 7;14(3):387-94. DOI:10.1016/s1097-2765(04)00235-7 |
- Xiang K, Nagaike T, Xiang S, Kilic T, Beh MM, Manley JL, and Tong L. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 2010 Oct 7;467(7316):729-33. DOI:10.1038/nature09391 |
