Difference between revisions of "Phosphatase Subfamily INPP4A"
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[[Non-protein_phosphatases|Non-protein phosphatases]]: [[Phosphatase_Subfamily_INPP4A|INPP4A subfamily]] | [[Non-protein_phosphatases|Non-protein phosphatases]]: [[Phosphatase_Subfamily_INPP4A|INPP4A subfamily]] | ||
| + | |||
| + | === Evolution === | ||
| + | INPP4A emerged in holozoa and duplicated in vertebrates, which resulted in two members in human genome and most if not all vertebrate genomes. | ||
| + | |||
| + | === Domain === | ||
| + | INPP4A has a structural domain at N-terminal (44-157 in human INPP4A) and a long C-terminal tail (158-977). | ||
| + | |||
| + | === Functions === | ||
| + | |||
| + | ===== Human INPP4B ===== | ||
| + | INPP4B is a PtdIns(3,4,5)P3 phosphatase that can act as a tumor suppressor <cite>Chew15, Kofuji15</cite>. | ||
| + | |||
| + | |||
| + | === References === | ||
| + | <biblio> | ||
| + | #Chew15 pmid=25883022 | ||
| + | #Kofuji15 pmid=25883023 | ||
| + | </biblio> | ||
Revision as of 18:26, 18 April 2015
Non-protein phosphatases: INPP4A subfamily
Contents
Evolution
INPP4A emerged in holozoa and duplicated in vertebrates, which resulted in two members in human genome and most if not all vertebrate genomes.
Domain
INPP4A has a structural domain at N-terminal (44-157 in human INPP4A) and a long C-terminal tail (158-977).
Functions
Human INPP4B
INPP4B is a PtdIns(3,4,5)P3 phosphatase that can act as a tumor suppressor [1, 2].
References
- Li Chew C, Lunardi A, Gulluni F, Ruan DT, Chen M, Salmena L, Nishino M, Papa A, Ng C, Fung J, Clohessy JG, Sasaki J, Sasaki T, Bronson RT, Hirsch E, and Pandolfi PP. In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer Discov. 2015 Jul;5(7):740-51. DOI:10.1158/2159-8290.CD-14-1347 |
- Kofuji S, Kimura H, Nakanishi H, Nanjo H, Takasuga S, Liu H, Eguchi S, Nakamura R, Itoh R, Ueno N, Asanuma K, Huang M, Koizumi A, Habuchi T, Yamazaki M, Suzuki A, Sasaki J, and Sasaki T. INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor. Cancer Discov. 2015 Jul;5(7):730-9. DOI:10.1158/2159-8290.CD-14-1329 |
