Phosphatase Subfamily PAPL

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Phosphatase Classification: Fold MTDP:Superfamily MTDP: Family PAP: PAPL


Evolution

PAPL subfamily is found in holozoa but lost from most arthropods. Humans have a single member, PAPL, but many invertebrates have multiple members

Domain Structure

PAPL has a phosphatase domain and a signal peptide cleavage site on N-terminus. Though predicted to be secreted, human PAPL is found mostly in the cytoplasm (http://www.proteinatlas.org/ENSG00000183760-PAPL/tissue).

Function

Unclear.