Difference between revisions of "Phosphatase Subfamily PGAM"
From PhosphataseWiki
(→Evolution) |
|||
| Line 3: | Line 3: | ||
=== Evolution === | === Evolution === | ||
| + | |||
| + | |||
| + | === Domain === | ||
| + | PGAM has single domain, phosphatase domain of HP1 family. | ||
| + | |||
| + | === Catalytic activity === | ||
Human has four members: | Human has four members: | ||
| − | * [[Phosphatase_Gene_BPGM|BPGM]]: 2,3-bisphosphoglycerate mutase <cite>wang04, wang06</cite> | + | * [[Phosphatase_Gene_BPGM|BPGM]]: 2,3-bisphosphoglycerate mutase. Bisphosphoglycerate mutase is an erythrocyte-specific en- zyme catalyzing a series of intermolecular phosphoryl group transfer reactions. Its main function is to synthesize 2,3- bisphosphoglycerate <cite>wang04, wang06</cite>. |
* [[Phosphatase_Gene_PGAM1|PGAM1]]: phosphoglycerate mutase 1 (brain) | * [[Phosphatase_Gene_PGAM1|PGAM1]]: phosphoglycerate mutase 1 (brain) | ||
* [[Phosphatase_Gene_PGAM2|PGAM2]]: phosphoglycerate mutase 2 (muscle) | * [[Phosphatase_Gene_PGAM2|PGAM2]]: phosphoglycerate mutase 2 (muscle) | ||
* [[Phosphatase_Gene_PGAM4|PGAM4]] (aka PGAM3): phosphoglycerate mutase family member 4 | * [[Phosphatase_Gene_PGAM4|PGAM4]] (aka PGAM3): phosphoglycerate mutase family member 4 | ||
| − | |||
| − | |||
| − | |||
Revision as of 04:11, 4 January 2015
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): HP, branch1 family: Subfamily PGAM
Evolution
Domain
PGAM has single domain, phosphatase domain of HP1 family.
Catalytic activity
Human has four members:
- BPGM: 2,3-bisphosphoglycerate mutase. Bisphosphoglycerate mutase is an erythrocyte-specific en- zyme catalyzing a series of intermolecular phosphoryl group transfer reactions. Its main function is to synthesize 2,3- bisphosphoglycerate [1, 2].
- PGAM1: phosphoglycerate mutase 1 (brain)
- PGAM2: phosphoglycerate mutase 2 (muscle)
- PGAM4 (aka PGAM3): phosphoglycerate mutase family member 4
