Difference between revisions of "Phosphatase Subfamily PPM1K"
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=== Evolution === | === Evolution === | ||
| − | The PPM1K subfamily | + | The PPM1K subfamily emerged in [[Phosphatase_Glossary#Holozoa|holozoa]]. It was lost in [[Phosphatase_Glossary#Ecdysozoa|ecdysozoa]] and sponge. PPM1K is most similar to the ER-anchored phosphatase subfamily [[Phosphatase_Subfamily_PPM1L|PPM1L]]. |
=== Domain === | === Domain === | ||
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=== Functions === | === Functions === | ||
| − | Human PPM1K is widely expressed in different tissues, most abundant in heart | + | Human PPM1K is widely expressed in different tissues, most abundant in heart <cite>Lu07, Joshi07</cite> and [http://www.gtexportal.org/home/gene/PPM1K GTEx database]. Human PPM1K is localized to mitochondrial matrix <cite>Lu07</cite>. It regulates mitochondrial membrane permeability transition pore (MPTP) opening, but the underlying molecular mechanism(s) is unclear <cite>Lu07</cite>. It also functions as pSer phosphatase of the branched-chain a-keto acid dehydrogenase complex <cite>Joshi07</cite>. |
| + | |||
=== References === | === References === | ||
<biblio> | <biblio> | ||
Revision as of 00:28, 4 March 2017
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1K (PP2Cκ, PP2Cm, BDP)
Evolution
The PPM1K subfamily emerged in holozoa. It was lost in ecdysozoa and sponge. PPM1K is most similar to the ER-anchored phosphatase subfamily PPM1L.
Domain
The PPM1K subfamily has an N-terminal mitochondria target signal (MTS) and phosphatase domain [1, 2]. The MTS (predicted by MitoProt) and phosphatase domain are conserved throughout the PPM1K subfamily.
Functions
Human PPM1K is widely expressed in different tissues, most abundant in heart [1, 2] and GTEx database. Human PPM1K is localized to mitochondrial matrix [2]. It regulates mitochondrial membrane permeability transition pore (MPTP) opening, but the underlying molecular mechanism(s) is unclear [2]. It also functions as pSer phosphatase of the branched-chain a-keto acid dehydrogenase complex [1].
References
- Joshi M, Jeoung NH, Popov KM, and Harris RA. Identification of a novel PP2C-type mitochondrial phosphatase. Biochem Biophys Res Commun. 2007 Apr 27;356(1):38-44. DOI:10.1016/j.bbrc.2007.02.108 |
- Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, and Wang Y. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes Dev. 2007 Apr 1;21(7):784-96. DOI:10.1101/gad.1499107 |
