Difference between revisions of "Phosphatase Subfamily PPM1Z"

Revision as of 17:49, 8 June 2015

Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1G2

Evolution

The PPM1G2 subfamily is named as PPM1G2, because 1) its sequence is more similar to PPM1G than other PPMs, and 2) it also has a N-terminal myristoylation site. It is conserved in opisthokont but lost in human, sponge and monosiga. Notice: Monosiga has a unclassified phosphatase that has a N-terminal myristoylation site but the overall sequence similarity does not well support it is PPM1G2.

Domain

The PPM1G2 subfamily has a N-terminal myristoylation site and a phosphatase domain. The phosphatase domain is closer to PPM1G than other PPMs in sequence, but it does not have the acidic domain inserted in catalytic domain which is common in PPM1G subfamily.

Functions

The most studied members of PPM1G2 subfamily are yeast PTC2, PTC3 and PTC4, whose functions were summarized in Table 1 of [1].

References

1. Sharmin D, Sasano Y, Sugiyama M, and Harashima S. Effects of deletion of different PP2C protein phosphatase genes on stress responses in Saccharomyces cerevisiae. Yeast. 2014 Oct;31(10):393-409. DOI:10.1002/yea.3032 | PubMed ID:25088474 | HubMed [Sharmin14]