Phosphatase Subfamily PTEN

Phosphatase Classification: Superfamily CC1: Family PTEN: Subfamily PTEN

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PTEN subfamily is named after its single member in human, PTEN, which dephosphorylates phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN is one of the most commonly lost tumor suppressors in human cancer.

Evolution

PTEN is found in almost all eukaryotes.

Domain Structure

Most PTEN have a phosphatase domain followed by a C2 domain. Some homologs have PH (phospholipid-binding) or LIM domains, but these are not conserved.

Functions

PTEN is a critical negative regulator of PI3K signaling.