Phosphatase Subfamily TIGAR
From PhosphataseWiki
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): HP, branch1 family: Subfamily TIGAR
Vertebrate TIGAR functions as a fructose- 2,6-bisphosphatase, which results in an inhibition of glycolysis and an overall decrease in intracellular reactive oxygen species (ROS) levels. TIGAR is also found in some basal eumetazoan, but is absent from nematodes and arthropoda.
Contents
Evolution
TIGAR is also found in some basal eumetazoan, but is absent from nematodes and arthropoda.
Domain
TIGAR has a single domain: HP1 phosphatase.
Functions
TIGAR is fructose- 2,6-bisphosphatase [1, 2], the same function with PFKFB1 of PFKFB. (PS: functional redundancy?)
References
- Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E, and Vousden KH. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell. 2006 Jul 14;126(1):107-20. DOI:10.1016/j.cell.2006.05.036 |
- Li H and Jogl G. Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator). J Biol Chem. 2009 Jan 16;284(3):1748-54. DOI:10.1074/jbc.M807821200 |
