Difference between revisions of "Phosphatase Subfamily UBLCP1"

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m (Gerard moved page UBLCP1 to Phosphatase Subfamily UBLCP1)
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==[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]:[[UBLCP1]]==
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]: [[Phosphatase_Subfamily_UBLCP1|Subfamily UBLCP1]]
  
== Introduction ==
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UBLCP1 is named after Ubiquitin-like domain containing CTD phosphatase 1. It has an accessary N-terminal domain, similar to ubiquitin. Its function is not well characterized, though in vitro assay showed phosphatase activity toward RNA polymerase II C-terminal domain <cite>clone</cite>.
UBLCP1 is named after Ubiquitin-like domain containing CTD phosphatase 1. It has an accessary N-terminal domain, similar to ubiquitin. Its function is not well characterized, though in vitro assay showed its phosphatase activity toward RNA polymerase II C-terminal domain <cite>clone</cite>.
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===Evolution===
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It is conserved from Nematostella to human but lost in nematode. However, UBLCP1-like proteins can be found in plants.
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===Domain Structure===
  
 
== Related Kinases ==
 
== Related Kinases ==
 
See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]].
 
See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]].
 
== Evolutionary History ==
 
It is conserved from Nematostella to human but lost in nematode. However, UBLCP1-like proteins can be found in plant.
 
 
== Domain Combination ==
 
 
  
 
== Catalytic activity ==
 
== Catalytic activity ==
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== Curation notes ==  
 
== Curation notes ==  
 
  
 
== References ==
 
== References ==
 
 
<biblio>
 
<biblio>
 
#clone pmid=15883030
 
#clone pmid=15883030

Revision as of 05:35, 29 December 2014

Phosphatase Classification: FCP: Subfamily UBLCP1

UBLCP1 is named after Ubiquitin-like domain containing CTD phosphatase 1. It has an accessary N-terminal domain, similar to ubiquitin. Its function is not well characterized, though in vitro assay showed phosphatase activity toward RNA polymerase II C-terminal domain [1].

Evolution

It is conserved from Nematostella to human but lost in nematode. However, UBLCP1-like proteins can be found in plants.

Domain Structure

Related Kinases

See Phosphorylation of RNA polymerase II C-terminal domain.

Catalytic activity

It has a different catalytic motif from other subfamilies of FCP.

Curation notes

References

  1. Zheng H, Ji C, Gu S, Shi B, Wang J, Xie Y, and Mao Y. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1401-7. DOI:10.1016/j.bbrc.2005.04.065 | PubMed ID:15883030 | HubMed [clone]


Links

Human UBLCP1 from NCBI Gene