Difference between revisions of "Phosphatase Subfamily VSP"

From PhosphataseWiki
Jump to: navigation, search
(Evolution)
(Domain Structure)
Line 10: Line 10:
  
 
===Domain Structure===
 
===Domain Structure===
 +
VSPs consist of an N-terminal voltage sensor with four transmembrane regions, followed by a phosphatase domain and a PTEN_C2 domain
  
 
===Functions===
 
===Functions===

Revision as of 00:19, 29 December 2014

Phosphatase Classification: Superfamily CC1: Family PTEN: Subfamily VSP

This page is a stub - more information to follow.

The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in holozoa but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication.

Evolution

VSPs are holozoan-specific and lost in both nematodes and insects. There are two human genes, TPTE (PTEN2) and TPTE2 (TPIP).

Domain Structure

VSPs consist of an N-terminal voltage sensor with four transmembrane regions, followed by a phosphatase domain and a PTEN_C2 domain

Functions

References

  1. []