Difference between revisions of "Phosphatase Subfamily VSP"
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| + | Both human genes are testis specific (GTEx: [http://www.gtexportal.org/home/gene/TPTE TPTE], [http://www.gtexportal.org/home/gene/TPTE TPTE2]) and are localized to the Golgi apparatus <cite>Guipponi</cite> | ||
===References=== | ===References=== | ||
<biblio> | <biblio> | ||
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Revision as of 00:27, 29 December 2014
Phosphatase Classification: Superfamily CC1: Family PTEN: Subfamily VSP
This page is a stub - more information to follow.
The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in holozoa but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication.
Evolution
VSPs are holozoan-specific and lost in both nematodes and insects. There are two human genes, TPTE (PTEN2) and TPTE2 (TPIP).
Domain Structure
VSPs consist of an N-terminal voltage sensor with four transmembrane regions, followed by a phosphatase domain and a PTEN_C2 domain
Functions
Both human genes are testis specific (GTEx: TPTE, TPTE2) and are localized to the Golgi apparatus [1]
