Technical Note PTPN14

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Phosphatase Classification: Superfamily CC1: Family PTP: Subfamily PTPN14

PTPN14 subfamily technical notes

PTPN14 is generally poorly conserved between the FERM and phosphatase domains, but does have a number of motifs that are highly conserved between vertebrate members (PTPN14 and PTPN21) and invertebrate members. From N- to C-termini, these motifs are:

  • P[st]YRp[ats]PDY[de].~
  • SQPE~
  • RPPY....sSTPdLa
  • S[sn]PDLVS


Letters in square brackets are optional, lowercase is less conserved ~=small hydrophobic. Note the similarity between motifs 3 and 4.

Motif 3 includes a PPxY motif that interacts with WW domains, and is known to be involved in bindings the WW domains of KIBRA (WWC1) and YAP. A second PPxY motif is found in vertebrate and some invertebrate forms, with a consensus of PPxYPG.

Gerard (talk) 03:30, 18 May 2016 (UTC)