Gene AqueLMWPTP-like-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC2
Superfamily CC2
Family LMWPTP
Subfamily AqueLMWPTP-like
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP155_AA protein Get Run
AqueP155_AA_28-201 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0046251 Phosphotyrosine protein phosphatases I 29-201 1.2e-16 51.7 In-house 5-155 (159) alignment 
Range on Protein: 29-201
Range on HMM: 5-155/159.0
PSKLLFVCSGNSCRSPMAMIVAEKMEAEREKI---IESDSAAGNFKNgkfvASQSPARNAIKALEAeYGRTRLeeYEPKPLKKEDIEKADKVIFLGaefR
. |.|||| ||.||||||  ..... ....     || |||.    .      ..| ..|...|.  .|      . .. |..||.|..| .. ..   .
kkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalh....vgeppdpravavlke.lgidls..hrarqlteedfeefdlilamd...d

KNAEDAKKLFGDALDGKAMYYCTYVNKQDskdKERHEVPDPLDGDnwpeyygeekpgRGQFRSYTKVLKSMIKDFY
.|..| ..|. . . || .... ...  .    . ..||||  |.            .  |.   . ..  .....
snlrdllrlapgdargkvllllefaglle...llhwdvpDPyygg............leaFeevldlieeaveall
0042188 Phosphotyrosine protein phosphatases I 29-199 2e-16 50.8 In-house 4-138 (146) alignment 
Range on Protein: 29-199
Range on HMM: 4-138/146.0
PSKLLFVCSGNSCRSPMAMIVAEKMEaerEKIIESDSAAgnfkNGKFVASQSPARNAIKALEAEygRTRLEEYEPKPLKKEDIEKADKVIFLGAEfrkNA
. |.|||| ||.||||||  .....    .. .| |||      . .. .... . |...|..      .... ...|..||.|..| |. .. .   |.
kkkvlfvCtgNicRSpmAeallrhll...gdrvevdSAG....tsayhvgepvdpravevlael..gidisghrarqlteedleefDlvltmdds...nl

EDAKKLFGDALDGKAMYYCTYVnkqdskdkerhEVPDPLDGDNwpeyygeekpgrgQFRSYTKVLKSMIKD
.|. .|| .|. || .... ..           .||||  |..              |.   . ... .|.
rdllplfpgaakgkvllllefw...........dvpDPyygge.............afeevldlieeavka
0053360 Phosphotyrosine protein phosphatases I 29-197 2.1e-16 50.8 In-house 5-149 (157) alignment 
Range on Protein: 29-197
Range on HMM: 5-149/157.0
PSKLLFVCSGNSCRSPMAMIVAEKMEAEREKI--IESDSAAGnfknGKFVASQSPARNAIKALEAeYGRTRLeeYEPKPLKKEDIEKADKVIFLGAefrK
. |.|||| ||.||||||  ..... .|..    .| |||      . .  .... . |...|.  .|      . ...|..||.|..| .. ..    .
mkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGt....salhvggpvdpravevlae.lgidls..hrarqlteedleefdliltmdd...s

NAEDAKKLFGD--ALDGKAMYYCTYVnkqdskDKERHEVPDPLdgdnwpeYYGEEkpgrgQFRSYTKVLKSMI
|.|.. .|| .     || .... ..      . . ..||||        | |.|      |. . . .....
nleellplfpglleakgkvllllefa......gllhwdvpDPy.......yggle.....afelvldlieeav
subfamily_Sponge-LMWPTP-like_pd Subfamily Sponge-LMWPTP-like 30-202 8.5e-123 396.3 In-house 1-173 (173) alignment 
Range on Protein: 30-202
Range on HMM: 1-173/173.0
SKLLFVCSGNSCRSPMAMIVAEKMEAEREKIIESDSAAGNFKNGKFVASQSPARNAIKALEAEYGRTRLEEYEPKPLKKEDIEKADKVIFLGAEFRKNAE
|||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||.||||||||||||||||||||||.|||||||
skllfvcsgnscrspmamivaekmeaerekiiesdsaagnfkngkfvasqspavnaikaleaeygrtrlkeyepkplkkediekadkviflgvefrknae

DAKKLFGDALDGKAMYYCTYVNKQDSKDKERHEVPDPLDGDNWPEYYGEEKPGRGQFRSYTKVLKSMIKDFYP
||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||.|||||.||||||
dakklfgdaldgkamyyctyvnkqdskdkerhevpdpldgdnwpeyygeekpgrrqfrsyakvlkslikdfyp
0048765 Phosphotyrosine protein phosphatases I 30-199 3.1e-16 50.2 In-house 3-148 (154) alignment 
Range on Protein: 30-199
Range on HMM: 3-148/154.0
SKLLFVCSGNSCRSPMAMIVAEKMEAEREKI--IESDSAAGnfknGKFVASQSPARNAIKALEAeYGRTRLeeYEPKPLKKEDIEKADKVIFLGAefrKN
 |.|||| ||.||||||  ..... .|..    .| |||      . .. .... ..|...|.  .|      . ...|..||.|..| .. ..    .|
kkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGt....sayhvgepvdpravevlae.lgidls..hrarqlteedleefdliltmdd...sn

AEDAKKLFGD--ALDGKAMYYCTYVNKqdskdkERHEVPDPLdgdnwpeYYGEEkpgrgQFRSYTKVLKSMIKD
.|.. .|| .     || .... ...       . ..||||        | |.|      |.   . .......
leellplfpglleakgkvllllefagl......lhwdvpDPy.......yggle.....afeevldlieeavea
0047572 Phosphotyrosine protein phosphatases I 30-170 1.1e-13 41.6 In-house 3-109 (130) alignment 
Range on Protein: 30-170
Range on HMM: 3-109/130.0
SKLLFVCSGNSCRSPMAMIVAEKMEAERekiIESDSAAGNfkngkfvaSQSPARNAIKALEAeyGRTRLEEYEPKPLKKEDIEKADKVIFLGAEfrkNAE
 |.|||| ||||||||| ...... ..|   .| .||  .         ...  .|...|.       .... .|.|........| || .. .   . |
kkvlfvCtgNscRSpmAeallrhllgdr...vevySAGte........gsgvdpravevlae..lgidisghrskqldelllpefdlvitmdds...ale

DAKKLFGDALDGKAmyyctyvnkqdskdkerhEVPDPLDGD
.   |...||                      ..|||  |.
alpllapaalrlhw..................dipDPyggg
0047618 Phosphotyrosine protein phosphatases I 31-174 8.4e-15 45.4 In-house 3-112 (137) alignment 
Range on Protein: 31-174
Range on HMM: 3-112/137.0
KLLFVCSGNSCRSPMAMIVAEKMEAERekiIESDSAAGNFKNgkfvasqsPARNAIKALEAeyGRTRLEEYEPKPLKKEDIEKADKVIFLGAEfrkNAED
|.|||| ||.|||||| ...... ..|   .| |||    ..        . ..|...|.       .... .|.| ..|....| |. .. .   . |.
kvlfvCtgNicRSpmAeallrhllgdr...vevdSAGtepag........vdpravevlae..lgidisghrskqldeldlpefdlvltmdds...alea

AKKLFGDALDGKAmyyctyvnkqdskdkerhEVPDPLDGDNWPE
   |...||  .                   .||||  |.. .|
lpllapaalrlhw..................dvpDPyygggtee
0051181 Phosphotyrosine protein phosphatases I 31-171 2e-14 44.2 In-house 1-104 (124) alignment 
Range on Protein: 31-171
Range on HMM: 1-104/124.0
KLLFVCSGNSCRSPMAMIVAEKMEAErekiIESDSAAGnfkngkfVASQSPARNAIKALEAEYGRTRleeYEPKPLKKEDIEKADKVIFLGAEfrkNAED
|.|||| ||.||||||  ..... ..    .| |||          ..... . |...|.     .    . .|.|...|.|..| |. .. .   | ..
kvlfvCtgNicRSpmAeallrhllgd....vevdSAGt.......hpggpvdpravevlaelgidls...lrskqldeldleefdlvltmdds...nlcp

AKKLFGdaldgkamyyctyvnkqdskDKERHEVPDPLDGDN
   |.                       . ..||||  |. 
llplap....................lllhwdvpDPyyggl
LMWPc_SSU72_ArsC 31-166 1.4e-11 35.4 In-house 2-111 (126) alignment 
Range on Protein: 31-166
Range on HMM: 2-111/126.0
KLLFVCSGNSCRSPMAMIVAEKMEAErekIIESDSAAGNFKNgkfvASQSPARNAIKALEAE-YgrtRLEeYEPKPLKKEDIEKADKVIFLGAEfrkNAE
| ||||.||.||||||  | .|. ..    .. .||. .  .      .|. ..|...|... .   .|.   |..|..||....| ....  .   | .
kvlfvClgNicRSpmAeavlkkavkk...glnvsSaGtgaav....pgksidsravellkengi...elk.hkprqlqeedlkefdliltmder...nkd

DAKKLFGDAlD-GKAMYYctyvnkqdskdkeRHEVPDP
. ..|.       |                   .|.||
evlellper.atkkvhll.............nldvkDp
subfamily_LMWPTP_pd Subfamily LMWPTP 31-154 1.8e-10 30.8 In-house 3-116 (152) alignment 
Range on Protein: 31-154
Range on HMM: 3-116/152.0
KLLFVCSGNSCRSPMAMIVAEKMEAEREKI--IESDSAAgnfkNGKFVASQSPARNAIKALEaEYGRTRLeeYEPKPLKKEDIEKADKVIFLGAEfrkNA
|.|||| || ||||.| .| .|. ....     . ||||      ..   ..| . |...|. ..|...      . ..||| .. | .. .  .   | 
kvlfvClGniCrspiaEavlrklvekkglkedwkvdsaa....issyhvGkepdkRalsilk.khglkss..hrarqitkedfsefdyilamDes...nl

EDAKKLFGDALDGKAMyyCTYVNKQD
.. |||  .  . ||    . . ..|
kelkklakekkeskak..vlllgeyd
LMWPc_SSU72 31-124 2.9e-09 27.9 In-house 2-84 (137) alignment 
Range on Protein: 31-124
Range on HMM: 2-84/137.0
KLLFVCSGNSCRSPMAMIVAEKMEAerekIIESDSAAgnfkNGKFVASQSPARNAIKALEAEYGrtRLEeYEPKPLKKEDIEKADKVIFLGAEF
|.||||..|..||..|  ..... .     .| .||      |. |  .|. ..| ......    ...   |. |..|. ||.| || |  . 
kvlfVCasNinRSmeAeallkeale....glevkSaG....tgslvpgpsidkpaeelykenGl..sik.eapeklqeeelekfDlvitleerv
LMWPc Low molecular weight phosphotyrosine protein phosphatase 33-170 7.7e-15 46.0 Pfam-A 2-119 (138) alignment 
Range on Protein: 33-170
Range on HMM: 2-119/138.0
LFVCSGNSCRSPMAMIVAEKMEAER-EKIIESDSAAGNfkngKFvASQSPARNAIKALEAEygRTRLEEYEPKPLKKEDIEKADKVIFLGAEfrkNAEDA
|||| ||.||||||  .....  .. .. .| |||. .     .  ..|. ..|...|. .    ....  ...|..|.....| .. | .|   .|...
lfvCtgNicRSpmAeallrallekalgdkvevdSAGte....al.vgesvdpravevlkek..gidisghrarqlseeelkefDliltldee...aarel

KKLFGDALDGKAMYYCTyvnkqdskdkeRHEVPDPLDGD
....     .| .  .            . ..|||  ..
cpvapekkeakvvllge...........qwdipDPygke
LMWPc Low molecular weight phosphotyrosine protein phosphatase 33-170 7.7e-15 46.0 In-house 2-119 (138) alignment 
Range on Protein: 33-170
Range on HMM: 2-119/138.0
LFVCSGNSCRSPMAMIVAEKMEAER-EKIIESDSAAGNfkngKFvASQSPARNAIKALEAEygRTRLEEYEPKPLKKEDIEKADKVIFLGAEfrkNAEDA
|||| ||.||||||  .....  .. .. .| |||. .     .  ..|. ..|...|. .    ....  ...|..|.....| .. | .|   .|...
lfvCtgNicRSpmAeallrallekalgdkvevdSAGte....al.vgesvdpravevlkek..gidisghrarqlseeelkefDliltldee...aarel

KKLFGDALDGKAMYYCTyvnkqdskdkeRHEVPDPLDGD
....     .| .  .            . ..|||  ..
cpvapekkeakvvllge...........qwdipDPygke