Gene AqueLMWPTP-like-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC2
Superfamily CC2
Family LMWPTP
Subfamily AqueLMWPTP-like
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP156_AA protein Get Run
AqueP156_AA_8-171 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0046251 Phosphotyrosine protein phosphatases I 9-171 5.3e-17 52.9 In-house 5-145 (159) alignment
Range on Protein: 9-171
Range on HMM: 5-145/159.0
PSKLLFVCSGNSCRSPMAMIVAEKMEADRGKI---IESDSAAGNFKNgkfvASQSPAVNAIRALEAVYGQTRlkeYTPKPLKKEDIEKADKVIFLGvefR
. |.|||| ||.||||||  ..... .|.|     || |||.    .      ..|  .|...|. .   .    .... |..||.|..| .. ..   .
kkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalh....vgeppdpravavlkelgidls...hrarqlteedfeefdlilamd...d

KNAEDAKKLFGDALDGKAMYYCTYVNKQDskdKERHEVPDPLDGDnwpeyygeekpgYRQFSSYAK
.|..| ..|. . . || .... ...  .    . ..||||  |.            .. |    .
snlrdllrlapgdargkvllllefaglle...llhwdvpDPyygg............leaFeevld

0042188 Phosphotyrosine protein phosphatases I 9-152 1.3e-16 51.4 In-house 4-124 (146) alignment
Range on Protein: 9-152
Range on HMM: 4-124/146.0
PSKLLFVCSGNSCRSPMAMIVAEKMEADRgkiIESDSAAgnfkNGKFVASQSPAVNAIRALEAVygQTRLKEYTPKPLKKEDIEKADKVIFLGvefRKNA
. |.|||| ||.||||||  ..... .||   .| |||      . .. ....   |...|...  .  ........|..||.|..| |. ..   ..|.
kkkvlfvCtgNicRSpmAeallrhllgdr...vevdSAG....tsayhvgepvdpravevlael..gidisghrarqlteedleefDlvltmd...dsnl

EDAKKLFGDALDGKAMYYCTYVnkqdskdkerhEVPDPLDGDNW
.|. .|| .|. || .... ..           .||||  |...
rdllplfpgaakgkvllllefw...........dvpDPyyggea

0053360 Phosphotyrosine protein phosphatases I 9-150 2.7e-16 50.4 In-house 5-134 (157) alignment
Range on Protein: 9-150
Range on HMM: 5-134/157.0
PSKLLFVCSGNSCRSPMAMIVAEKMEADRGKI--IESDSAAGnfknGKFVASQSPAVNAIRALEAVYGQTRlkeYTPKPLKKEDIEKADKVIFLGVefrK
. |.|||| ||.||||||  ..... ...|    .| |||      . .  ....   |...|. .   .    .....|..||.|..| .. ..    .
mkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGt....salhvggpvdpravevlaelgidls...hrarqlteedleefdliltmdd...s

NAEDAKKLFGD--ALDGKAMYYCTYVnkqdskDKERHEVPDPLDGD
|.|.. .|| .     || .... ..      . . ..||||  |.
nleellplfpglleakgkvllllefa......gllhwdvpDPyygg

subfamily_Sponge-LMWPTP-like_pd Subfamily Sponge-LMWPTP-like 10-182 1e-122 396.1 In-house 1-173 (173) alignment
Range on Protein: 10-182
Range on HMM: 1-173/173.0
SKLLFVCSGNSCRSPMAMIVAEKMEADRGKIIESDSAAGNFKNGKFVASQSPAVNAIRALEAVYGQTRLKEYTPKPLKKEDIEKADKVIFLGVEFRKNAE
||||||||||||||||||||||||||.|.||||||||||||||||||||||||||||.||||.||.||||||.|||||||||||||||||||||||||||
skllfvcsgnscrspmamivaekmeaerekiiesdsaagnfkngkfvasqspavnaikaleaeygrtrlkeyepkplkkediekadkviflgvefrknae

DAKKLFGDALDGKAMYYCTYVNKQDSKDKERHEVPDPLDGDNWPEYYGEEKPGYRQFSSYAKVLKSMIQDFYP
|||||||||||||||||||||||||||||||||||||||||||||||||||||.|||.||||||||.|.||||
dakklfgdaldgkamyyctyvnkqdskdkerhevpdpldgdnwpeyygeekpgrrqfrsyakvlkslikdfyp

0048765 Phosphotyrosine protein phosphatases I 10-150 3.8e-16 50.0 In-house 3-131 (154) alignment
Range on Protein: 10-150
Range on HMM: 3-131/154.0
SKLLFVCSGNSCRSPMAMIVAEKMEADRGKI--IESDSAAGnfknGKFVASQSPAVNAIRALEAVYGQTRlkeYTPKPLKKEDIEKADKVIFLGVefrKN
 |.|||| ||.||||||  ..... ...|    .| |||      . .. ....  .|...|. .   .    .....|..||.|..| .. ..    .|
kkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGt....sayhvgepvdpravevlaelgidls...hrarqlteedleefdliltmdd...sn

AEDAKKLFGD--ALDGKAMYYCTYVNKqdskdkERHEVPDPLDGD
.|.. .|| .     || .... ...       . ..||||  |.
leellplfpglleakgkvllllefagl......lhwdvpDPyygg

0047572 Phosphotyrosine protein phosphatases I 10-150 1.3e-13 41.5 In-house 3-109 (130) alignment
Range on Protein: 10-150
Range on HMM: 3-109/130.0
SKLLFVCSGNSCRSPMAMIVAEKMEADRgkiIESDSAAGNfkngkfvaSQSPAVNAIRALEAvyGQTRLKEYTPKPLKKEDIEKADKVIFLGVEfrkNAE
 |.|||| ||||||||| ...... .||   .| .||  .         ...  .|...|.    .  ......|.|........| || .. .   . |
kkvlfvCtgNscRSpmAeallrhllgdr...vevySAGte........gsgvdpravevlae..lgidisghrskqldelllpefdlvitmdds...ale

DAKKLFGDALDGKAmyyctyvnkqdskdkerhEVPDPLDGD
.   |...||                      ..|||  |.
alpllapaalrlhw..................dipDPyggg

0047618 Phosphotyrosine protein phosphatases I 11-155 7.3e-15 45.6 In-house 3-113 (137) alignment
Range on Protein: 11-155
Range on HMM: 3-113/137.0
KLLFVCSGNSCRSPMAMIVAEKMEADRgkiIESDSAAGNFKNgkfvasqsPAVNAIRALEAvyGQTRLKEYTPKPLKKEDIEKADKVIFLGVEfrkNAED
|.|||| ||.|||||| ...... .||   .| |||    ..        .  .|...|.    .  ......|.| ..|....| |. .. .   . |.
kvlfvCtgNicRSpmAeallrhllgdr...vevdSAGtepag........vdpravevlae..lgidisghrskqldeldlpefdlvltmdds...alea

AKKLFGDALDGKAmyyctyvnkqdskdkerhEVPDPLDGDNWPEY
   |...||  .                   .||||  |.. .| 
lpllapaalrlhw..................dvpDPyygggteee

0051181 Phosphotyrosine protein phosphatases I 11-150 2.5e-14 43.9 In-house 1-103 (124) alignment
Range on Protein: 11-150
Range on HMM: 1-103/124.0
KLLFVCSGNSCRSPMAMIVAEKMEADrgkiIESDSAAGnfkngkfVASQSPAVNAIRALEAVYGQTRlkeYTPKPLKKEDIEKADKVIFLGVEfrkNAED
|.|||| ||.||||||  ..... .|    .| |||          .....   |...|. .  ..    ...|.|...|.|..| |. .. .   | ..
kvlfvCtgNicRSpmAeallrhllgd....vevdSAGt.......hpggpvdpravevlaelgidls...lrskqldeldleefdlvltmdds...nlcp

AKKLFGdaldgkamyyctyvnkqdskDKERHEVPDPLDGD
   |.                       . ..||||  |.
llplap....................lllhwdvpDPyygg

LMWPc_SSU72_ArsC 11-146 3.4e-12 37.4 In-house 2-111 (126) alignment
Range on Protein: 11-146
Range on HMM: 2-111/126.0
KLLFVCSGNSCRSPMAMIVAEKMEADrgkIIESDSAA-GNFKNGKFVASQSPAVNAIRALeavygqtRLKeYTPKPLKKEDIEKADKVIFLGvefRKNAE
| ||||.||.||||||  | .|. ..    .. .||. |.   || . |.. .. . . .       .||  .|..|..||....| ....    ..| .
kvlfvClgNicRSpmAeavlkkavkk...glnvsSaGtgaavpgksidsravellkengi.......elk.hkprqlqeedlkefdliltmd...ernkd

DAKKLFGDAlD-GKAMYYctyvnkqdskdkeRHEVPDP
. ..|.       |                   .|.||
evlellper.atkkvhll.............nldvkDp

subfamily_LMWPTP_pd Subfamily LMWPTP 11-122 2.7e-10 30.3 In-house 3-106 (152) alignment
Range on Protein: 11-122
Range on HMM: 3-106/152.0
KLLFVCSGNSCRSPMAMIVAEKMEADRGKI--IESDSAA-GNFKNGKfvasqSPAVnaiRALEAVYGQTRLKEYTPKPLKKEDIEKADKVIFLGvefRKN
|.|||| || ||||.| .| .|. ...|     . ||||  ... ||     .|     |||...  . . .. . . ..||| .. | .. .     .|
kvlfvClGniCrspiaEavlrklvekkglkedwkvdsaaissyhvGk.....epdk...RalsilkkhglksshrarqitkedfsefdyilamD...esn

AEDAKKLFGDALDGK
 .. |||  .  . |
lkelkklakekkesk

LMWPc_SSU72 11-101 1.3e-09 29.0 In-house 2-81 (137) alignment
Range on Protein: 11-101
Range on HMM: 2-81/137.0
KLLFVCSGNSCRSPMAMIVAEKMEAdrGKIIESDSAAGNFkNGKFVASQSPAVNAIRALeavygqtRLKeYTPKPLKKEDIEKADKVIFLG
|.||||..|..||..|  ..... .  |  ..|         |. .  ..... . . |       ..|  .|. |..|. ||.| || | 
kvlfVCasNinRSmeAeallkeale..glevkSaGtgslv.pgpsidkpaeelykenGl.......sik.eapeklqeeelekfDlvitle

LMWPc Low molecular weight phosphotyrosine protein phosphatase 13-150 2.2e-14 44.5 Pfam-A 2-119 (138) alignment
Range on Protein: 13-150
Range on HMM: 2-119/138.0
LFVCSGNSCRSPMAMIVAEKMEADR-GKIIESDSAAGNfkngKFvASQSPAVNAIRALEAVygQTRLKEYTPKPLKKEDIEKADKVIFLgveFRKNAEDA
|||| ||.||||||  .....  .. |. .| |||. .     .  ..|.  .|...|.    . .... ....|..|.....| .. |    ...|...
lfvCtgNicRSpmAeallrallekalgdkvevdSAGte....al.vgesvdpravevlkek..gidisghrarqlseeelkefDliltl...deeaarel

KKLFGDALDGKAMYYCTyvnkqdskdkeRHEVPDPLDGD
....     .| .  .            . ..|||  ..
cpvapekkeakvvllge...........qwdipDPygke

LMWPc Low molecular weight phosphotyrosine protein phosphatase 13-150 2.2e-14 44.5 In-house 2-119 (138) alignment
Range on Protein: 13-150
Range on HMM: 2-119/138.0
LFVCSGNSCRSPMAMIVAEKMEADR-GKIIESDSAAGNfkngKFvASQSPAVNAIRALEAVygQTRLKEYTPKPLKKEDIEKADKVIFLgveFRKNAEDA
|||| ||.||||||  .....  .. |. .| |||. .     .  ..|.  .|...|.    . .... ....|..|.....| .. |    ...|...
lfvCtgNicRSpmAeallrallekalgdkvevdSAGte....al.vgesvdpravevlkek..gidisghrarqlseeelkefDliltl...deeaarel

KKLFGDALDGKAMYYCTyvnkqdskdkeRHEVPDPLDGD
....     .| .  .            . ..|||  ..
cpvapekkeakvvllge...........qwdipDPygke