Gene PPP1C-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP174_AA protein Get Run
AqueP174_AA_5-305 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049330 Metallo-dependent phosphatases 6-305 4.4e-116 380.2 In-house 5-304 (309) alignment 
Range on Protein: 6-305
Range on HMM: 5-304/309.0
DKLNVDNIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETI
|.| ....|..||..  ... | ..|.| ... |.|| .||..|.|.||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||..
dpllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevl

CLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDL
.||||.|..||.|.||||||||.. .|..|||.||..|.|...||. |.|....||.||....||.|.||||||||....|||...||...|. ||||||
llllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl

LWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASDRRK
||.||. ..  ...|.||....||. .| .|| |..||||.|.|..|..||..|....|.|.||||||||...|.||.. .||.|..||....|..   .
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll
subfamily_PPZ_pd Subfamily PPZ 9-300 3.7e-139 456.4 In-house 2-294 (300) alignment 
Range on Protein: 9-300
Range on HMM: 2-294/300.0
NVDNIIQKLLEVR-GSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
..|.||||||.    ..  ||| | ...|  .| |.||.||.|| ||||  ..|| ||.|||| ||||||   |||| .||||||||||||||||||| |
dideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
||.||||||||||||||||||| . |.|||||||||| ||..|||| | || ||.|||.  |||| |||||| |.||..||...||||||| ||. ||||
llcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllw

ADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
.||   .  | .|.||||. .    . ||| |  .||.|||| |||||||||  | |||.|||||||||||| ||.||| | |.|||..| | 
sdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 9-301 3.9e-136 445.9 In-house 2-295 (298) alignment 
Range on Protein: 9-301
Range on HMM: 2-295/298.0
NVDNIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
.||... ..|.|  |      ...|.|.  |. ....|| .|. |.|..||.|.|||||||| ||||||. .||||..||||||||||||.|.||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
||||.|||.|||||||||||..|||.||||.|||||| ..||...| | || ||..|.. ..|.| |||||. |.|..|.|.. ||.| ... |  ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

ADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAS
|||.. .  | || ||||..|| . | ..| | |.||..|||||| |||||||...|||.||||.|||.|||. |.|.||| |..||..|||..
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 9-302 1.2e-127 418.3 In-house 2-296 (299) alignment 
Range on Protein: 9-302
Range on HMM: 2-296/299.0
NVDNIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
.||... |||.|  |       . | ... ||  ....|.||. |||.|||...|||||||| ||||.|.  ||||..|.||||||||||.| ||.|.||
dvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
|..||||||.||.||||||| .|||.||||.||..||.  |||  | |.|. .|.. ..  .|.| |||||| ||...|.| . || | |.  |  ||||
lcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllw

ADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASD
||||.  . |  | ||||. ||...|.. . . |.||..||||||.|||||||...|||.|||| |||.|||. |.| ||| |.|.|..|||.. 
adpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpk
0045823 Metallo-dependent phosphatases 9-303 7.5e-119 390.3 In-house 21-327 (473) alignment 
Range on Protein: 9-303
Range on HMM: 21-327/473.0
NVDNIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
 .... .  |..  ..  |. .|.| |.. |. . .||. ..| ||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...||
lfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlell

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWA
||.|||||.|.||||||||.. .| .|||.||. ..|...|.. | .....||.||....||...||||||||....|||.| || ..|| |||.||||.
lalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllws

DPdKETVA--------WGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQ------LVTLFSAPNYCGEFDNAGAMMSVDETLmCSF
||  |.          .| . ||....|||..| .|| |..||||.|.|..|..|||.. ...      ..|.||||||||...| .|.. .||.| .||
dP.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isf

QILKPASDR
....|... 
iqfdpsphp
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 10-301 5.4e-107 350.5 In-house 2-296 (297) alignment 
Range on Protein: 10-301
Range on HMM: 2-296/297.0
VDNIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLL
||.||  .|            .||  .  |   . ..| .|  ..|..||.|.|||||||. ||||||  ||.|| .||||||||||||. |.||| |||
vdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlll

AYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSP---DLQSMEQIRRIMRPTDVpDQGLLCDL
|||.|.| |.|||||||||  .|..||||.||..||. .|.. .| | || ||.. .. .||.| ||||||   .  ... .|.| |.|.   ..|..||
aykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadl

LWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAS
|||||      . ||.||    || . | |   . .|||.|||||||.||||||| |.|||.|||| |||.|||. |.||.|| | |||.||.|.|
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpts
0053225 Metallo-dependent phosphatases 12-299 2.9e-105 344.7 In-house 3-290 (293) alignment 
Range on Protein: 12-299
Range on HMM: 3-290/293.0
NIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAY
..|. ||..  ..  ....|.| ... |.|. .||....|.||||.... ..|||||...|||.|.|. |||||....||||.|||| .|||...||||.
slilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllal

KIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADP
|..||.|..|||||||.. .| .|||.||..|.| . .||. ..|....||.||....||...|||||||| ...|||.|.||...|. |||.|||| ||
kllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp

DkETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
| .   |. . ||....||. .| .|| |..||||.|.|||| |||... ...|||.||||||.|...|.||.. .|| |...|....|
d.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_PPP1C_pd Subfamily PPP1C 23-301 1.6e-162 532.4 In-house 2-280 (282) alignment 
Range on Protein: 23-301
Range on HMM: 2-280/282.0
SRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
|..||.|.|.||.|. |. |.|||.||||||||||||.||.|||||||.|||||||..|.|||||||||||||||||||||||.||||||||||||.|||
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDR
|||||.|||||||||||||||||.|.|||||||.|||||.||..||||.|.||||||.|.|.||||.|.||..||..||||||||.|||||.. |.||||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAS
|||||||...|.||| |.|||||.||||||||||||||||||||.|||||||||||||||..||||.|..||||||||.
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
subfamily_PPP2C_pd Subfamily PPP2C 28-302 2.3e-100 328.5 In-house 14-288 (290) alignment 
Range on Protein: 28-302
Range on HMM: 14-288/290.0
NVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
  ||.|.... || | .||. ..  . |...|. .|||.|||..||| ||  ||  |..||||||||||||  |.||..|| | |..|.|   .||||||
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhe

CASINRIYGFYDECKRRY-NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDkETVAWGENDRGVSF
   | ..||||||| |.| |  .|| ||| |..||..|..||.||| |||||| ......|| . |  .||..| ||||||.||| .   ||  .||  .
srqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagy

TFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASD
||| .|  ||  . .| || ||||.| .||..  .|..||.|||||||    | .|.. .|..|  ||   .||. 
tfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 28-302 9.8e-99 323.1 In-house 5-279 (281) alignment 
Range on Protein: 28-302
Range on HMM: 5-279/281.0
NVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
.||.|. .|  .  . . || ..  | |...| .. ||.|.|. || ||||  | .||  ..|||||||||.||||.. ||...||.|... .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFT
 ||.|.||||| ||. .| . ||  |  ||| ||..|  .... | ||||||.| .....| . .| . .|.||. ||||||||...  | .  ||.|||
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASD
|| ..| .   . ...|| |||||| |||| .. |.|.|.||.||||  . ||.|.. |||||  |.. | ||| 
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
subfamily_PPP3C_pd Subfamily PPP3C 28-291 1.3e-88 290.8 In-house 38-314 (452) alignment 
Range on Protein: 28-291
Range on HMM: 38-314/452.0
NVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
. .|.|...  .  .. ... ... |||.|||. ..||||||.||||.||| || | ...|||||||||||  |.|..  |.| ||.||...||||||||
egrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhe

CASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKET------VAWGEN-
|  .   . | .||| .|. .........|..||.||.|... .|.||||||...|...|... |  ..| .|.||||||.|| ..        .. .| 
crhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpns

DRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAK------RQLVTLFSAPNYCGEFDNAGAMMSVDETLM
 || |. .. . |..|| | ||  | |||.. ..||. . |        |.||||||||.. ..| .|.. ...  |
vrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 28-303 9.7e-77 251.1 In-house 17-295 (307) alignment 
Range on Protein: 28-303
Range on HMM: 17-295/307.0
NVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
..| |  ..  .  ... || |.  |.... |  . ||.|||. ||. .|   | |||. |.| |||||||  |||.| ||..||| ||||  |||||||
kiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhe

CASINRIYGFYDECKR---RYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGV
 | .|. ||||.||     .    .|  |  ||| ||..|..  ||.| |||||| |  ....|   .|   | .|.. |.||||||   . |    || 
iarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgs

SFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASDR
 |||| ...     .  ..|| ||||.. |||  .. |.|.|.|||| ||  . |||... |||||      . |.|. 
gftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesen
subfamily_PPP6C_pd Subfamily PPP6C 30-303 5e-93 304.4 In-house 14-287 (290) alignment 
Range on Protein: 30-303
Range on HMM: 14-287/290.0
QLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 |.|.|.. || .  ...| .  .  ...|. .|||||||.|||. ||  ||  |...|.||||.||||  ||||. .||. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRY-NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDkETVAWGENDRGVSFTF
 | ..|||||||...| |   || .|. |. |..|||.||...| |||||||.. ..||| | | ...| .| .|||.|.||. .  .|   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylf

GPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASDR
| .....|.   .|.|||||||.||.|.... . .|||..||||||    |  ........   .....|   |.
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpde
subfamily_PPG1_pd Subfamily PPG1 30-301 2.9e-85 279.2 In-house 13-297 (300) alignment 
Range on Protein: 30-301
Range on HMM: 13-297/300.0
QLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 | |. .. |. | .|.....  . |...|. . ||.|||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..||    |||||||  
llpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesr

SINRIYGFYDECKRRY--NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPD-----------KETVA
 | ..|||| || |.|  | |.|| .|. |. | .|||.||.|.| ||||||. .|..||. . |  .||..| |.||||.||.           .|   
qitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqh

WGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAS
. . .||  ...| ..| ||| . |.. | ||||.. .||. .   .| |..||||||    |  ... . | .   |.. . | 
fvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeap
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 30-298 1.9e-68 223.8 In-house 5-298 (302) alignment 
Range on Protein: 30-298
Range on HMM: 5-298/302.0
QLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPE
.... ..  |. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlypt

NFFLLRGNHECASINRIYGFYDECKRRY----NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWADP-D
|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||.||| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

KET-------VAWGEN-DRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
 ..        .. .|  ||.|..|    | ..  . .|.|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 30-298 3.5e-68 223.0 In-house 6-299 (302) alignment 
Range on Protein: 30-298
Range on HMM: 6-299/302.0
QLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPE
.... ..  |. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlypt

NFFLLRGNHECASINRIYGFYDECKRRY----NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWADP-D
|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||.||| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

KET-------VAWGEN-DRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
 ..        .. .|  ||.|..|    | ..  . .|.|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 31-300 4.3e-120 393.1 In-house 6-275 (280) alignment 
Range on Protein: 31-300
Range on HMM: 6-275/280.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
. |||| ..  | ..|.. |  ..|..||...|||.|||| ||||||.  .|||..||||||||||||.| || |.||||||..||.||..||||||..|
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

INRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFGP
||| |||.||.||||.  |.. | . .. ||..|..  .|.| |||||..|.|........|| | .|. |  |||||||....  |.|| ||||  || 
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

EIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
..| ..  | |.|||.| ||||.|||||||...|||.||||.|.|||||. |.. ||| |. ||..||||
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
PPP_3 31-298 1.3e-112 368.3 In-house 2-270 (271) alignment 
Range on Protein: 31-298
Range on HMM: 2-270/271.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
|.| ... |. | .||. ....|.|..||...|||||||..|||.||..||..||..||||||||||||.|||...||||.|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFG
||..|||..|.. .... ...|.....|..||.||..|||....||||||...|..||... |...||..|.|.|||. ......  .....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

PEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
|.....|| |..|.||.|||...|.|||.......||.|||||||....||||.....|.|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 31-299 1.2e-111 365.8 In-house 8-282 (284) alignment 
Range on Protein: 31-299
Range on HMM: 8-282/284.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFP------PESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRG
|.| ..  ||...||.|  ... ||.|||.||.||||||. ||| |..  |.|       |..|||||||||||  |.| | ||.|||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGV
|||   .|. |||| |||.||  .|...|  .||..|..|....||.| |||.| || ...|. .. ||.|.|| |...|| ||||..| . . | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
  .||.. | .|| |..|||. |||||| ||||||| |.|||.|||| |||..||..|...||| |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_PPP4C_pd Subfamily PPP4C 31-300 2.3e-102 335.1 In-house 16-285 (288) alignment 
Range on Protein: 31-300
Range on HMM: 16-285/288.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
..| ... || |.|||.. .  . ....|  .|||||||.||||.||. ||  || |||||||.||||. |.||. ||||.|..||..  |.|||||. .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

INRIYGFYDECKRRY-NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETvAWGENDRGVSFTFG
| ..||||||| |.| ....|.  |. |. |..|||.|.|||| ||||||.......|| | | ..||..| ||||||.||.. . .|.   ||  . ||
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagylfg

PEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
 ..|..|  . |..|||||||.| .|| .  .....|..||||||    |  |.. .||.|   |.|.. |
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 31-300 1.2e-94 309.5 In-house 10-282 (287) alignment 
Range on Protein: 31-300
Range on HMM: 10-282/287.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
... ||  .  | .||.   | |||.|||..|.||||||. ||||.|.  | .|. .||||||||||| .||| . ||...||.||..  |||||||.  
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

INRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP--DQGLLCDLLWADPDKETVAWGEN-DRGVSFT
||..|||..| ||... ||.|.| | |. ||. |.....|.| |||.||.|.|..... . .||     |.||  |||||||.|.. .   |  |..|  
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

FGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
|| . | ..| | |.||| |||.|.|.||.|.....|||.|||| |.||  | ||.. |...|  ||  ||| 
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 31-300 2.8e-84 275.5 In-house 16-289 (290) alignment 
Range on Protein: 31-300
Range on HMM: 16-289/290.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
... ||  .  | .||.   | |||.|||. | ||||||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.|...  |||||||.  
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

INRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTD--VPDQGLLCDLLWADPDK---ETVAWgENDRGVS
.||.|||..|  |. . |||| . | |. |.. | ...||.| |||.|....| | .. . .|      |.||  |||||||..   .|.|  .  |..|
vnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtial.nkqrais

FTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
  || . . ..| |  |.|| |||.| |.|..|  ...|||.|||| |.|.  | ||.. | |.|  |. .||| 
vvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 31-84 7.2e-17 54.5 In-house 9-62 (317) alignment 
Range on Protein: 31-84
Range on HMM: 9-62/317.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPP
..|...  ||...||.| ..|. ||||||..|.||||||. ||| |..  |.| 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
PP2Ac_SM00156 32-300 2.5e-115 377.2 In-house 2-270 (271) alignment 
Range on Protein: 32-300
Range on HMM: 2-270/271.0
TEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.. ... |. ...||. ... |.|..||. ..||||||..|||||.| .|.|||..|.|||||||||.||.|.|.||.|.||.|||...|||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFGPE
|.||||..|.||.|. .... |...|..||.||..|.||.| ||||||.|.|...||.. |. . |..|||.||||.||....  .  . ||.|..||..
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

IVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
.|..|| |..|.||.|||.||..||||||...|||.|||||||.||.|..|...|...|..|.. ||..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 32-85 1.9e-12 39.9 In-house 12-65 (339) alignment 
Range on Protein: 32-85
Range on HMM: 12-65/339.0
TEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPE
  |..  || ..||.  |.||.|.||||. . ||||||. ||| ...  |.|  
caaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls
PPP_1 33-286 1.5e-113 371.5 In-house 3-264 (264) alignment 
Range on Protein: 33-286
Range on HMM: 3-264/264.0
EADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASIN
|. .. |. |..|.. ....|||.......|||||||..|||.||..||..||.|||||||||||||.|.|...||||.|.|||...||||||||.....
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

RIYGFYDECK-RRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL-------WADPDKETVAWGENDRGV
..|||..|.. ..|. ...||.||.|..||.||..||||...||||||.|....|||...| |.||..| |||||       . |..... |. ...||.
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

SFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
...||.....||| |..|.||.|||.|.|.||||..||..||.|||.||. |..|.||....
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 34-301 5.2e-106 347.2 In-house 6-275 (284) alignment 
Range on Protein: 34-301
Range on HMM: 6-275/284.0
ADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 |.  | ... .||  ||.|.| ..|..||||||||. ||||||.  |||  .|||||||||||||. |||| ||.|||. .|. ||.|||||||. ||.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

IYGFYDECKRRYNI-RLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQG-LLCDLLWADPDKETVAWGENDRGVSFTFGPE
|||||.||.||||   ....|   |  .|..|.. ..|.| |||.|  || . |.| | || | |.   |  |.||.|| .    |  | ||||. || .
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

IVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAS
 . |.| . ..||. ||||||.|||||||.|.|||.|||| |||.|||| |.| |.. |.||| .|.|  
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 38-300 3.5e-86 282.1 In-house 13-275 (280) alignment 
Range on Protein: 38-300
Range on HMM: 13-275/280.0
GLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGF
 .      ||. .  | | |||.|. |||| || |. |||.  |  || . .||||||||| | .| . ||.. ||.| .  .|||||||  |.|.||||
aiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygf

YDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFGPEIVSKFL
| ||. .| . ||  |  ||| .|..... ....| ||||||.|  .. || | || .  |.||| ||||.|| ..  .|  . ||.|. ||  .| .  
yvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqac

CKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
   ..||| ||||||.||||..| |.|.|.|| |||| .| || |.. ..  |  ||| | | 
ksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPPLV_pd Subfamily PPPLV 38-290 3.2e-55 180.5 In-house 4-279 (290) alignment 
Range on Protein: 38-290
Range on HMM: 4-279/290.0
GLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLL----RLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 || .. .|....  ||||..|  . ||.||.| ||      |.  |     ...||||||||||. |.| |. ||| |. ||  ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYNIRL---WKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQI---RRIMR--PTDVPDQGLLCDLLWADPDKET-----------
 . .. |.. ..  .|   |..|...|. ||.||..|.|.||.|.|.    ..  .|   . |.   . |.    |  |.||.||...            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

VAWGEND-RGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAgAMMSVDETL
  . .|| || .  |. . . .|| . .|. . |||.| | |...  | .|.|.||. .|||  ..| |.. ||.  
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdkkk
subfamily_PPP5C_pd Subfamily PPP5C 40-288 5.8e-84 274.8 In-house 43-297 (322) alignment 
Range on Protein: 40-288
Range on HMM: 43-297/322.0
CLKSREIFLSQPILLELEAP----LKICGDIHGQYYDLLRLFEYGGFPPES-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRI
 |...|.. ..| |.|.. .    | .|||||||.|||| .||  | | |.  ||| ||.||||  |.|.| .||..|. ||..||| |||||  ..|..
lleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkl

YGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGL-SPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETvAWGENDRGVSFTFGPEIV
||| .|.| .|. .. . ||. || ||.| ...||.. .|||| | |  .....|.| | .. |..|||..|||.||....   ..  |||...|||.. 
yGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqean.GrspskrGvgvqfGpdvt

SKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV-DE
.||| . .|.|| |.|.| |.|||.  . .|.|.||||||| . .| ||.... ..
kkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 53-300 3.6e-72 236.2 In-house 2-256 (263) alignment 
Range on Protein: 53-300
Range on HMM: 2-256/263.0
LLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNI-----
||||.||..|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.  | ...|||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

RLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPD-QGLLCDLLWADPDKETVAWGEND-RGVSFTFGPEIVSKFLCKHDLDLI
 ... | . |. .|..||. ..|.| |||.|| |.|...|| |  | .    . | ||||||||.|..  .  |  | .|  || . |  .  . |.|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
 ||||||| || ||| |.|.|.|||  |  |. |  |.. |.. |  ||  ||| 
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpe
Metallophos Calcineurin-like phosphoesterase 60-251 3.9e-44 144.3 Pfam-A 3-198 (200) alignment 
Range on Protein: 60-251
Range on HMM: 3-198/200.0
LKICGDIHGQYYDL----LRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFLLRGNHECASINRIYGFYDECK-----------
  ..||.||...||    |.|.. .. ..  ..|||||.||||. |.||..||  |..|...| ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIrrimrptdvpdqgllcdllwadpdketvawge
                        ... . .  . ..|..|| .|. | ||...||.||....| ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGPEIVSKFLCKHDLDLICRAHQV
     |. |||. ..|.| |...||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 60-192 3.6e-38 124.3 In-house 66-201 (383) alignment 
Range on Protein: 60-192
Range on HMM: 66-201/383.0
LKICGDIHGQYYDLLRLFEYGGFPPE-SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY---NIRLWKTFTD
. .|||.||.  ||| ..   |.| |  .|.| ||.|||||.|.| ...|||. . ||....| |||||   .|  |||  | . .|   . .. ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPVAAILDEKIFCCHGGLSpDLQSMEQIRRIMR
 |  ||.|...||||. .|||.| |  ..| . .| |
vfawlplatlidekilivhGGis.dktdlelldkier
PPP_2 61-251 9e-82 266.5 In-house 2-197 (198) alignment 
Range on Protein: 61-251
Range on HMM: 2-197/198.0
KICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECK-RRYNIRLWKTFTDCFNC
..|||.|||..|||.||..|...||..||||||||||||.|||...||||.|..||....|||||||....|..|||..|.. .... ...|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL----WADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQV
||.||..|||....|||||.......||... |....|..|.|.|||    . ||....  . .. ||....|||......| |..|.||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 61-251 2.4e-78 255.7 In-house 2-196 (197) alignment 
Range on Protein: 61-251
Range on HMM: 2-196/197.0
KICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFN
 ..||||||..|| |.|...||.|. |..|.||||||||||.|||...||||.|..||....|||||||..|.|..|||..|...... ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQV
.||.||..|||....|||||..|.|...|.|| |....| ......|| ||.|| ...  . .. ||....|||....||| |..|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 61-252 1.3e-74 243.5 In-house 2-199 (199) alignment 
Range on Protein: 61-252
Range on HMM: 2-199/199.0
KICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRR-YNIRLWKTFTDCF
 .|||.|||..|| |.||. ||.|. | .|.||||||||||.|||...||||.|..||....|||||||. ..|.||||..|.... .. ...|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWADPD-KETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVV
..||.||..|||....||||||...|.|....| |....| ..|  .|| ||.||  . .  . .. ||....|||....||| |..|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_YNL217W_pd Subfamily YNL217W 61-178 7.6e-08 25.1 In-house 13-137 (235) alignment 
Range on Protein: 61-178
Range on HMM: 13-137/235.0
KICGDIHGQYYDLLRLFE--YGGFPPESNYLFLGDYVDRGKQSLETICLLlaykikYPENFFLLRGNHECASINRIygfydECKRRYNI-----------
 . ||.|| | .|..|..   ||  ..   ...|| ...| .|.|.. ..        ..   ..|||| . . ..     .  .. .            
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefsskfs

----RLWKTFTDCFNCLPVA-AILDEKIFCCHGGLS
    .| |  ..    |. .  |  ....  |.||.
flesklskadmeyarelgfsldipsdellvvhaGlv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 86-301 9.3e-98 320.3 In-house 101-316 (317) alignment 
Range on Protein: 86-301
Range on HMM: 101-316/317.0
SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSME
..|||||||||||  |.| . ||.|.|..||.. ||||||||  ..|. |||| |.|.||. .|...|   ||.||..|....||.| |||.| .| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMS
|. .. ||.|.|| |.|.|| |||||.|   . |  || .. ||.. | .|| |.||||. |||||||||||||| |.|||.||||.|||..||..|..|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDETLMCSFQILKPAS
||. |..|...|.| |
vdkklkisinvlrpes
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 87-304 8.8e-76 248.2 In-house 121-338 (339) alignment 
Range on Protein: 87-304
Range on HMM: 121-338/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQ
 |||||||||||  |.| . || | |. ||.  .|||||||  |.|  |||| | . ||. .|.. | . || .|..|.... |.| |||.|  | |..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
.  . || ..|| |.| || |||||     .    || || |||  .  || | ||... | |||||||||||  |.|||.||||||||. ||. |..|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DETLMCSFQILKPASDRR
|. |  | ....| |  .
dkklkisinvfrpesrdk
subfamily_PPP7C_pd Subfamily PPP7C 202-294 2.9e-20 65.4 In-house 237-329 (383) alignment 
Range on Protein: 202-294
Range on HMM: 237-329/383.0
LCDLLWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSF
. |.||.|| ...  . .  ||    |||.. .|.| |..|.|. |.|.   .||||  .....|.||| ||  |  | || . . ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri