Gene PPP1C-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP175_AA protein Get Run
AqueP175_AA_6-304 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPZ_pd Subfamily PPZ 7-301 1.2e-135 444.8 In-house 1-296 (300) alignment 
Range on Protein: 7-301
Range on HMM: 1-296/300.0
IDIDSIISRLLEAR-GSRTMKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETIC
.||| || .||.|   ..  | | | ..|.  .| |.|..|| || ||||  ..|. ||.||||.||||||    ||| .||||||||||||||||||| 
vdideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletil

LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLL
|||.||||||||||||||||||| . |.|||||||.|| |||||||| | || ||.||..  |||| |||||| |. ...|| ..||||||| ||. |||
lllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindll

WSDPDKDIQGWGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPSEK
||||    . | .|.||||. .    . ||||.  .||.|||| |||||||||  | |||.||||||||..|| | .|.. | |.|||..| | . 
wsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 7-304 2.9e-130 426.9 In-house 1-299 (299) alignment 
Range on Protein: 7-304
Range on HMM: 1-299/299.0
IDIDSIISRLLEARGSRTMKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICL
.|.| ..|.||.   |    |  . | |.. ||  ....|..|. |||.|||..|||||||||.||||.|.  .|||..|.||||||||||.| ||.|.|
ldvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitl

LLAYKIKYPENFFLLRGNHECASINRIYGFYDECRRRYN-IKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLL
||..||||||.||.||||||| .|||.||||.|| .||.  ..|  | |.|. .|.. .|  .|.| |||||| ||...|.| ..|| | |.  |  |||
llcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidll

WSDPDKDIQGWGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPSEKKAK
|.|||. ...|  | ||||. || |.|.. ..| |.||..||||||.||||||| ..|||.|||| |||..||.  .| .||.|.|.|..|||..|..|
wadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpkslk
0049330 Metallo-dependent phosphatases 7-304 8.1e-116 379.3 In-house 7-304 (309) alignment 
Range on Protein: 7-304
Range on HMM: 7-304/309.0
IDIDSIISRLLEARGSRTMKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICL
......| .||..  ....|.. | | |.. |.|| ..|....|.||||.... |.||||||..|||||.|   ||| ....||||.|||| .|||...|
llllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlll

LLAYKIKYPENFFLLRGNHECASINRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLW
|||.|..||.|.||||||||.. .|..|||.||. |.|....|. |.|....||.||||..||.|.||||||||.  .|||.. ||...|..||||||||
llalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllw

SDPDKDIQGWGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPSEKKAK
|||. .. |...|.||....||...| .||....||||.|.|..|..||..|. ..|.|.|||||||| ..|.|....|||.|..||....|.. . .
sdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 8-302 2.3e-137 449.9 In-house 2-297 (298) alignment 
Range on Protein: 8-302
Range on HMM: 2-297/298.0
DIDSIISRLLEARGSRTMKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLL
..|......|..  | .  |  . |..|. |. ....|| .|. |.|..||.||||||||||.||||||. ..|||..||||||||||||.|.||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECRRRY-NIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLW
||||.|||.|||||||||||..|||.||||.||.||| .......| | || ||..|.| ..|.| |||||. |. ..|.|.. ||.| ... |  ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

SDPDKDIQGWGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPSEKK
.||.. ..|| || ||||..||.| | ..|.. |.||..|||||| ||||||| ..|||.||||.|||..||. ..|..||.|..||..|||..|.
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 9-299 8.3e-107 349.8 In-house 2-295 (297) alignment 
Range on Protein: 9-299
Range on HMM: 2-295/297.0
IDSIISRLLEARGSRTMKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLL
.||||  .| |     . .  ..|  |  |   . |.|  |  ..|..||.|||||||||. ||||||  | .|| .||||||||||||. |.||| |||
vdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlll

AYKIKYPENFFLLRGNHECASINRIYGFYDECRRRYN-IKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSP---DLQDFEQIRSIARPTDVpDTGLLCDL
|||.|.| |.|||||||||  .|..||||.||..||. .... .| | || ||.. .| .||.| ||||||   .   .. .| | |.|.    .|..||
aykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadl

LWSDPDKDIQGWGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPS
||.||   . |. ||.||    || | | |     .|||.|||||||.||||||| |.|||.|||| |||..||.  .|. ||.| |||.||.|.
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
0053225 Metallo-dependent phosphatases 12-299 1.3e-106 349.1 In-house 4-291 (293) alignment 
Range on Protein: 12-299
Range on HMM: 4-291/293.0
IISRLLEARGSRTMKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYK
.| .||..  .. .....| |.|.. |.|. ..|....|.||||.... |.|||||...|||.|.|.  ||| ....||||.|||| .|||...||||.|
lilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalk

IKYPENFFLLRGNHECASINRIYGFYDECRRRY-NIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPD
..||.|..|||||||.. .| .|||.||. |.| . ..|. ..|....||.||.|..||...||||||||  ..|||.| ||...|..|||.||||||||
llypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd

kDIQGWGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPS
 .. ||. . ||....||...| .||....||||.|.|||| |||...  ..|||.||||||.| ..|.|.....||.|...|....|.
.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
0045823 Metallo-dependent phosphatases 21-303 1.8e-118 389.1 In-house 34-328 (473) alignment 
Range on Protein: 21-303
Range on HMM: 34-328/473.0
GSRTMKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
 .. .|   | |.... |. . ..|. ..| ||||.... |.||||||..|||||.|   ||| ....||||.|||| .|||...||||.|||||.|.||
iehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfl

LRGNHECASINRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPdKDIQG-----
||||||.. .| .|||.||....|...... | .....||.||||..||...||||||||.  .|||.| || ..|| |||.|||||||  .. |     
lrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllr

---WGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQ------LVTLFSAPNYCGDYDNAGGMMTIDEELmCSFQILKPSEKKA
   .| . ||....||.|.| .||....||||.|.|..|..|||.. ...      ..|.|||||||| ..| .....|||.| .||....||. . 
lrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpl
subfamily_PPP1C_pd Subfamily PPP1C 23-301 2.8e-159 521.7 In-house 3-281 (282) alignment 
Range on Protein: 23-301
Range on HMM: 3-281/282.0
RTMKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLR
.. |.|.| |.|..||. |.|.|.|.||||||||||.|..|||||||.|||||||.. .||..|||||||||||||||||||.||||||||||||.||||
kkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHECASINRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDKDIQGWGENDRG
||||.|||||||||||||.|||.||.||||||.|||||.||..|.||.|.||||||.|...||||.|.||..||..|||||||||||||...||.|||||
GnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

VSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPSEK
||||||.|.|.|||...|||||.||||||||||||||.|||||.|||||||| .||||.....||||..|||||||..|
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_PPP2C_pd Subfamily PPP2C 23-302 7.1e-102 333.5 In-house 10-289 (290) alignment 
Range on Protein: 23-302
Range on HMM: 10-289/290.0
RTMKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLR
. ... .| |.|||.|| | ..|. ..  . |...|. ||||.|||. ||| ||  |   |.|||||||||||||  |.||..|| | |..|.|   .||
klkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilr

GNHECASINRIYGFYDECRRRY-NIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDkDIQGWGENDR
||||   | ..||||||| |.| | ..|| ||| |..||..|..|..||| |||||| .. ...||.. |  .||. | |||||||||| | .|||  .|
gnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgispr

GVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPSEKK
|  .||| ||  || .. .| || ||||.| .||..   |..||.|||||||    | .... .|..|  ||   .|. ..
gagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_PPP4C_pd Subfamily PPP4C 24-298 8.6e-105 343.1 In-house 10-284 (288) alignment 
Range on Protein: 24-298
Range on HMM: 10-284/288.0
TMKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRG
 ... ...|.|||||| |.|.|..|.  . ....|  ||||||||. |||.||. |   |.||||||||.||||. |.||. ||||.|..||..  |.||
lrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirg

NHECASINRIYGFYDECRRRY-NIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDkDIQGWGENDRG
|||. .| ..||||||| |.| ....|.  |. |. |..||.||.|||| ||||||... ...|||| | ..||. | |||||||||. |..||.   ||
nhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprg

VSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKP
  . ||.|.|..| .. |..|||||||.| .|| .  .....|..||||||    |   .. .||||   |.|.. 
agylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifea
subfamily_PPG1_pd Subfamily PPG1 24-296 4.4e-85 278.5 In-house 8-293 (300) alignment 
Range on Protein: 24-296
Range on HMM: 8-293/300.0
TMKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRG
  |.  | |. ||.|. | .......  . |...|. | ||.|||. |.| .|. |   | |||||||||||||  |.||| ||.. |..||    ||||
lqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrg

NHECASINRIYGFYDECRRRY--NIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPD---------KD
|||   | ..|||| || |.|  | ..|| .|. |. | .||.||..|.| ||||||. .  .||. . |  .||. | |.|||||||.          |
nhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpd

IQG--WGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQIL
 .|  . . .||  ...| |.| |||.  |.. | ||||.. .||. .   .| |..||||||    |   .. . | .   |.. 
regqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 25-293 5.4e-76 248.7 In-house 15-286 (307) alignment 
Range on Protein: 25-293
Range on HMM: 15-286/307.0
MKTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGN
.. .. .  |.. .  ... ||  .  |.... |  | ||.|||. ||. .|     || | |.| |||||||  |||.| ||..||| ||||  |||||
vhkiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgn

HECASINRIYGFYDECRR---RYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDKDIQGWGENDR
|| | .|. ||||.||     .   .||  |  ||| |||.|.|  ||.| |||||| |  ....|   .|   |  |.. |.||.|||  .  |    |
heiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassr

GVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSF
|  ||||....    .|  ..|| ||||.. |||  .. |.|.|.|||| ||  | ||| .. .|| |    
gsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiql
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 26-300 5.2e-99 324.0 In-house 4-278 (281) alignment 
Range on Protein: 26-300
Range on HMM: 4-278/281.0
KTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNH
. |.... |....  . . || |.  | |...| .| ||.|.|..|| ||||  . .|.. ..|||||||||.||||.. ||...||.|... .||||||
hkvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnh

ECASINRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDKDIQGWGENDRGVSF
| ||.|.||||| ||  .| ...|  |  ||| |||.| |. .. | ||||||.|   ...| . .| . .| ||. ||||.|||.. ..| .  ||.||
eiasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssf

TFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPSE
||| ..| .   | ...|| |||||| |||| .. |.|.|.||.||||  | ||. ....||.|  |.. | |. 
tfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_PPP3C_pd Subfamily PPP3C 26-290 7.2e-89 291.6 In-house 37-314 (452) alignment 
Range on Protein: 26-290
Range on HMM: 37-314/452.0
KTVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNH
|  .| |...  .  .. ... ... |||.|||. |.||||||. |||.||| |  | .|.|||||||||||  |.|..  |.| ||.||...|||||||
kegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnh

ECASINRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDKDIQGWG-------E
||  .   . | .||. .|. .........|..||.||..... .|.||||||.......|... |  ..| .|.||||||||| .| .          .
ecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpn

NDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFAR------RQLVTLFSAPNYCGDYDNAGGMMTIDEELM
. || |. ..   |..||.. ||  | |||.. ..||. . .        |.||||||||.. |.| . .. .... |
svrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_PPP6C_pd Subfamily PPP6C 27-297 3.2e-94 308.3 In-house 12-282 (290) alignment 
Range on Protein: 27-297
Range on HMM: 12-282/290.0
TVHLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
  .|.|...|.|| .  |..||.  .  ...|. ||||||||. ||. ||  |   |.|.|.||||.||||  ||||. .||. |.|||..  |||||||
ckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhe

CASINRIYGFYDECRRRY-NIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPdKDIQGWGENDRGVSF
.  | ..||||||| ..| | . || .|. |. |.|||.||....| |||||||.. ..||| | | ...|  | .|||.|||| .|.. |   .||  .
srqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagy

TFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILK
 ||. ....|..  .|.|||||||.||.|....   .|||..||||||    |   .......   .....|
lfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 29-298 9.5e-68 221.6 In-house 6-300 (302) alignment 
Range on Protein: 29-298
Range on HMM: 6-300/302.0
HLAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGS------------FpPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPE
.. ..|. .|. .  . . ..  | |. .|. . ||||||. ||.|.. .              |  .  ..|||||||||..|.| |||..|.|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlypt

NFFLLRGNHECASINRIYGFYDECRRR----YNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARP-TDVPDTGLLCDLLWSDPDk
|. |||||||. .||  ||| .|   |       .||. | ..|  .|.||.. .||.| |||.|| |. .|.|..| || ..| .  |  |||..||  
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl.

DIQG---------WG-ENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKP
|.|.         .  .. ||.|..|    |... .| .|.|| ||||..  |. ||| ..|.|.||||.|  . || | .. .| .   | ..|..
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 30-301 1.1e-118 388.4 In-house 6-277 (280) alignment 
Range on Protein: 30-301
Range on HMM: 6-277/280.0
LAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
. |......  | ..|.. |  ..|..||..||||.|||||||||||.  |||| .||||||||||||.| || |.||||||..||.||..||||||..|
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

INRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDKDIQGWGENDRGVSFTFGA
||| |||.||..|||. .... | . .. ||..|..  .|.| |||||..|. ..... . || | .|  |  ||||.||.... ||.|| ||||  |||
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

DIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPSEK
..| .. .. |.|||.| ||||.||||||| ..|||.||||.|.|..||. ... .||.|. ||..|||. .
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalr
PPP_3 30-297 2.5e-113 370.6 In-house 2-270 (271) alignment 
Range on Protein: 30-297
Range on HMM: 2-270/271.0
LAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
| |.|.| |. | ..|. ....|.|..||..||||||||..|||.||..| ..|.|.||||||||||||.|||...||||.|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECR-RRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDKDIQGWGENDRGVSFTFG
||..|||..|.  .... |..|.....|..||.||.||.|....||||||... ..||... |...||..|.|.|||.|..... .|.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

ADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILK
.|....||....|.||.|||...|.|||.......||.|||||||. ..||| .....|.|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 30-298 6.5e-111 363.3 In-house 8-282 (284) alignment 
Range on Protein: 30-298
Range on HMM: 8-282/284.0
LAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFP------PHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRG
| |.|.  ||...|..| .... ||.|||.|..||||||. ||| |..   .|       ...|||||||||||  |.| | ||.|||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDKDIQGWGENDRGV
|||   .|. |||| ||..||  .....|  .||..|..||...||.| |||.| || |..|.  . ||.|.|| |...|| |.||.....|. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKP
  .|||. | .||....|||. |||||| ||||||| |.|||.|||| |||..||.. ....||||..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 30-298 4.7e-68 222.6 In-house 6-299 (302) alignment 
Range on Protein: 30-298
Range on HMM: 6-299/302.0
LAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGS------------FpPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPEN
. ..|. .|. .  . . ..  | |. .|. . ||||||. ||.|.. .              |  .  ..|||||||||..|.| |||..|.|. ||.|
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlyptn

FFLLRGNHECASINRIYGFYDECRRR----YNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARP-TDVPDTGLLCDLLWSDPDkD
. |||||||. .||  ||| .|   |       .||. | ..|  .|.||.. .||.| |||.|| |. .|.|..| || ..| .  |  |||..||  |
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl.d

IQG---------WG-ENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKP
.|.         .  .. ||.|..|    |... .| .|.|| ||||..  |. ||| ..|.|.||||.|  . || | .. .| .   | ..|..
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 30-82 1.2e-15 50.5 In-house 9-61 (317) alignment 
Range on Protein: 30-82
Range on HMM: 9-61/317.0
LAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFP
. |.|.  ||...|..| ..|. ||||||....||||||. ||| |..   .|
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 30-82 3.4e-11 35.8 In-house 11-63 (339) alignment 
Range on Protein: 30-82
Range on HMM: 11-63/339.0
LAETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFP
.. .|.  || ..|..   .||.|.||||. | ||||||. ||| ...   .|
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
PP2Ac_SM00156 31-299 3.8e-115 376.6 In-house 2-270 (271) alignment 
Range on Protein: 31-299
Range on HMM: 2-270/271.0
AETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.. ||..|. ....|. ... |.|..||. |.||||||..|||||.| . .||...|.|||||||||.||.|.|.||.|.||.|||...|||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDKDIQGWGENDRGVSFTFGAD
|.||||..|..|.|. .|.. |...|..||.||..|.||.| ||||||.|. ...||.. |. . |. |||.|||||||... .|.  . ||.|..||.|
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

IVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPS
.|..||....|.||.|||.||..||||||...|||.|||||||. ..|.. .......|..|.. ||. 
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
PPP_1 31-284 1.2e-111 365.2 In-house 2-263 (264) alignment 
Range on Protein: 31-284
Range on HMM: 2-263/264.0
AETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.|.|...|. |..... ....|||......||||||||..|||.||..| ..|.||||||||||||||.|.|...||||.|.|||...||||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECR-RRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLL-------WSDPDKDIQGWGENDRG
...|||..|.. ..|. .|.||.||.|..||.||.||.||...||||||.|.  .||| . | |.||..| |||||       .||.... ... ...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMT
....||.|...|||....|.||.|||.|.|.||||...|..||.|||.||.   .|.| ...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_PPP5C_pd Subfamily PPP5C 31-293 7.3e-83 271.2 In-house 35-303 (322) alignment 
Range on Protein: 31-293
Range on HMM: 35-303/322.0
AETEVKALCLKSRDIFLEQPILLELEAP----LKVCGDIHGQYTDLLRLFEY-GSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNH
 .  . .. |...... ..| |.|.. .    | ||||||||. ||| .||  |.  ..  ||| ||.||||  |.|.| .||..|. ||..||| ||||
hkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnh

ECASINRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGL-SPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDKdIQGWGENDRGVS
|  ..|..||| .|.. .|. |. . ||. || ||.| ||..|.. .|||| | |   ....| | | .. |. |||..||||||..  .| ..  |||.
esdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvg

FTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTI-DEELMCSF
..|| |. .|||.  .|.|| |.|.| |.|||.    .|.|.||||||| . .| |...|. ...|   |
vqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkf
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 32-304 2.1e-109 358.4 In-house 5-279 (284) alignment 
Range on Protein: 32-304
Range on HMM: 5-279/284.0
ETEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASIN
  .|..| ... .|| .||.|.| ..|...|||||||..||||||.   || ..|||||||||||||. |||| ||.|||. .|. ||.|||||||. ||
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

RIYGFYDECRRRYNI-KIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTG-LLCDLLWSDPDKDIQGWGENDRGVSFTFGA
.|||||.||.||||   ....|   |  .|..|.. ..|.| |||.|  ||.  |.|.| || | |.   |  |.||||| .  .||  | ||||. ||.
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgs

DIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPSEKKAK
| . |.|.| ..||. ||||||.||||||| |.|||.|||| |||..|||  .| ....|.||| .|.| .| |.
dalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiar
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 33-301 1.6e-93 305.8 In-house 13-284 (287) alignment 
Range on Protein: 33-301
Range on HMM: 13-284/287.0
TEVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
...  .  | ..|.   | |||.|||....||||||. ||||.|.    .|...||||||||||| .||| . ||...||.||..  |||||||.  ||.
kdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkink

IYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDT--GLLCDLLWSDPDKDIQGWGEND-RGVSFTFGA
.|||..| .|... ...|.| | |. ||. | .. .|.| |||.||.|. ....... .||   .   ||  ||||.||.|| ..   |  |..|  || 
lyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGk

DIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPSEK
  | ..|.. |.||| |||.|.|.||.|.. ..|||.|||| |.|.  | | ...... |  ||  ||| . 
kevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 34-299 2.2e-86 282.8 In-house 10-275 (280) alignment 
Range on Protein: 34-299
Range on HMM: 10-275/280.0
EVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRI
|. |.      ||.|.  | | |||.|| |||| || |. |||.     |  . .||||||||| | .| . ||.. ||.| .  .|||||||  |.|.|
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

YGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLLWSDPDKDIQGWGENDRGVSFTFGADIVT
|||| ||. .| . .|  |  ||| .|....|  ...| ||||||.| ... || | || .  | ||| ||||||| .  .||  . ||.|. ||  .| 
ygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvve

KFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPS
.  .  ..||| ||||||.||||..| |.|.|.|| |||| .. ||  .. .. .|  ||| | | 
qacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 34-299 6.4e-82 267.8 In-house 20-289 (290) alignment 
Range on Protein: 34-299
Range on HMM: 20-289/290.0
EVKALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRI
..  .  | ..|.   | |||.|||. . ||||||  .||| |.   .||. ..|||||||||| .|||   ||. |||.|...  |||||||.  .||.
dileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrl

YGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTD--VPDTGLLCDLLWSDPDKDI-QGWG-ENDRGVSFTFGA
|||..|  |. . ..|| . | |. |.. | .. ||.| |||.|.... .| .... .|      | ||  ||||.||..|  .    .  |..|  || 
ygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgk

DIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPS
. . ..|..  |.|| |||.| |.|..|   ..|||.|||| |.|.  | | ..|. | |  |. .||| 
kglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_PPPLV_pd Subfamily PPPLV 36-288 2.7e-58 190.6 In-house 3-278 (290) alignment 
Range on Protein: 36-288
Range on HMM: 3-278/290.0
KALCLKSRDIFLEQPILLELEAPLKVCGDIHGQYTDLL----RLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASIN
 .|| .. ||....  ||||..|  | ||.||.| ||      |.  |     ...||||||||||. |.| |. ||| |. ||  ..|||||||  |. 
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

RIYGFYDECRRRYNI---KIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIAR-----PTDVPDTGLLCDLLWSDPDKDI----------
  . .. |.  ..     ..|..|...|. ||.|||||.|.||.|.|.    .   .| .|       . |.  . |  |.|||||..|           
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

-QGWGEND-RGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGgMMTIDEE
 .|. .|| || .  |..| . .||.| .|. . |||.| | |...  . .|.|.||. .|||  ..|  .. .|..
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaa.lilvdkk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 52-300 8.5e-72 235.0 In-house 2-257 (263) alignment 
Range on Protein: 52-300
Range on HMM: 2-257/263.0
LLELEAPLKVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECRRRYNI-----
||||.||...||| |||| ||||.|.      .|.||||||||||| .||| | ||.. |.  | ...|||||||  .||. |||. | ..|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDT-GLLCDLLWSDPDKDIQGWGEND-RGVSFTFGADIVTKFLNRHDLDLI
 ... | . |. .|..|..  .|.| |||.|| |. ...||.|  | .   |  | |||||.||.|| .|.  |  | .|  ||   |  . .| |.|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQILKPSE
 ||||||| || ||| |.|.|.|||  |  .  |   .. ... |  ||  ||| .
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
Metallophos Calcineurin-like phosphoesterase 59-250 4.7e-45 147.3 Pfam-A 3-198 (200) alignment 
Range on Protein: 59-250
Range on HMM: 3-198/200.0
LKVCGDIHGQYTDL----LRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFLLRGNHECASINRIYGFYDECR-----------
  |.||.||.. ||    |.|.. .. .. ...|||||.||||. |.||..||  |..|...| ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQIrsiarptdvpdtgllcdllwsdpdkdiqgwge
                        ... ...  . ..|..||..| .| ||...||.||....  ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGADIVTKFLNRHDLDLICRAHQV
     |. || | . |.|.....||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 59-191 4.1e-38 124.1 In-house 66-201 (383) alignment 
Range on Protein: 59-191
Range on HMM: 66-201/383.0
LKVCGDIHGQYTDLLRLFEYGSFPP-HTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECRRRY---NIKIWKTFTD
. ||||.||.  ||| ..    .|  . .|.| ||.|||||.|.| ...|||. . ||....| |||||   .|  |||  |   .|   . || ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPIAAVIDDKIFCCHGGLSpDLQDFEQIRSIAR
 |  ||.|..||.||. .|||.| |  |.| . .|.|
vfawlplatlidekilivhGGis.dktdlelldkier
subfamily_YNL217W_pd Subfamily YNL217W 59-160 1.3e-07 24.3 In-house 12-104 (235) alignment 
Range on Protein: 59-160
Range on HMM: 12-104/235.0
LKVCGDIHGQYTDLLRLFE--YGSFPPHTNYLFLGDYVDRGKQSLETICLLlaykikYPENFFLLRGNHECASINRIygfydECRRRYNIKIWKTFTDCF
| | ||.|| | .|..|..   |   .    ...|| ...| .|.|.. ..        ..   ..|||| . . ..     .  .. .    ..|.. |
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefsskf

NCLP
. |.
sfle
PPP_2 60-250 9.2e-83 269.8 In-house 2-197 (198) alignment 
Range on Protein: 60-250
Range on HMM: 2-197/198.0
KVCGDIHGQYTDLLRLFEYGSFPPHTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECR-RRYNIKIWKTFTDCFNC
.||||.|||..|||.||..| ..|...||||||||||||.|||...||||.|..||....|||||||....|..|||..|.  .... |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVPDTGLLCDLL----WSDPDKDIQGWGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQV
||.||.||.|....|||||.... ..||... |....|..|.|.|||    .|||... ... .. ||....||.|.....|....|.||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 60-250 7.8e-79 257.3 In-house 2-196 (197) alignment 
Range on Protein: 60-250
Range on HMM: 2-196/197.0
KVCGDIHGQYTDL-LRLFEYGSFPP-HTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECRRRYNIKIWKTFTDCFN
 |.||||||..|| |.|...| .|. ...|.||||||||||.|||...||||.|..||....|||||||..|.|..|||..|. .... .|.|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVP-DTGLLCDL-LWSDPDKDIQGWGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQV
.||.||.||.|....|||||..|.. ..|. |.|....| . ....|| ||||| .. .|. .. ||....||.|...|||....|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 60-251 4.4e-75 245.0 In-house 2-199 (199) alignment 
Range on Protein: 60-251
Range on HMM: 2-199/199.0
KVCGDIHGQYTDL-LRLFEYGSFPP-HTNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECRRR-YNIKIWKTFTDCF
 ||||.|||. || |.||. | .|. ...|.||||||||||.|||...||||.|..||....|||||||. ..|.||||..|. .. .. ||.|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPIAAVIDDKIFCCHGGLSPDLQDFEQIRSIARPTDVP-DTGLLCDL-LWSDPDKDIQG-WGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVV
..||.||.||.|....||||||.... |... |.|....| ..|  .|| ||||| .. .| . .. ||....|| |.. |||....|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 85-299 4.3e-98 321.4 In-house 101-315 (317) alignment 
Range on Protein: 85-299
Range on HMM: 101-315/317.0
TNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFE
 .|||||||||||  |.| . ||.|.|..||.. ||||||||  ..|. |||| |...||. .....|   ||.||..||...||.| |||.| .| |..
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRSIARPTDVPDTGLLCDLLWSDPDKDIQGWGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMT
|.  . ||.|.|| |.|.|| |.|||....|. |  || .. |||. | .||...||||. |||||||||||||| |.|||.||||.|||. ||.. ...
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

IDEELMCSFQILKPS
.|..|..|...|.|.
vdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 86-302 3.8e-75 246.1 In-house 121-337 (339) alignment 
Range on Protein: 86-302
Range on HMM: 121-337/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECRRRYNIKIWKTFTDCFNCLPIAAVIDDKIFCCHGGLSPDLQDFEQ
 |||||||||||  |.| . || | |. ||.  .|||||||  |.|  |||| |   ||. .... | . || .|..|||.. |.| |||.|  |  |.|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRSIARPTDVPDTGLLCDLLWSDPDKDIQGWGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTI
.  . || ..|| |.| || |.|||   .|.    || || ||   .  ||.. ||... | |||||||||||  |.|||.||||||||. ||.  ...|
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DEELMCSFQILKPSEKK
|..|  | ....|  . 
dkklkisinvfrpesrd
subfamily_PPP7C_pd Subfamily PPP7C 201-296 3.9e-20 64.9 In-house 237-332 (383) alignment 
Range on Protein: 201-296
Range on HMM: 237-332/383.0
LCDLLWSDPDKDIQGWGENDRGVSFTFGADIVTKFLNRHDLDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGDYDNAGGMMTIDEELMCSFQIL
. |.||||| ..   . .  ||    ||.|. .|.|....|.|. |.|.   .||||   ....|.||| ||     | |  . . ..|.  .   
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqy