Gene PPP2C in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP176_AA protein Get Run
AqueP176_AA_9-298 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP7C_pd Subfamily PPP7C 8-189 7.4e-40 129.8 In-house 15-202 (383) alignment 
Range on Protein: 8-189
Range on HMM: 15-202/383.0
IEPKELDKWIAKLEDCKQLEENNVKNLCEKAKELLSQESNVQEVKC----PVTVCGDVHGQFHDLMELF-RIGGKSPDTNYLFMGDYVDRGYYSVETVSL
....|..| | ..   |.|  . | ..  .||. | |  |...|.      ||||||.||.. ||. .. . |  |.. .|.| ||.||||  ||| . .
ltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveilli

LVALKVRFPNRITILRGNHESRQITQVYGFYDECLRKY--GNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDtLDHIRSLDRL
|.|| . .|. . . |||||   .   |||  |   ||   . .. . . |.| .|||..|.| .|. .|||.| . | |. . ...| 
llalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkiers
0045823 Metallo-dependent phosphatases 10-297 1e-120 396.5 In-house 27-326 (473) alignment 
Range on Protein: 10-297
Range on HMM: 27-326/473.0
PKELDKWIAKLEDCKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVR
.  ||..|  |  ...|.|. ...|...|||.|..|.|..|.. ...|.||.|||..||..|... |  |.....|.||.||||..|.|.. || |||..
lldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkik

FPNRITILRGNHESRQITQVYGFYDECLRKYgNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDR
.|.....||||||.|.....|||.||.|.|| . .....| .....|||.|...|.|.. ||||||....|| ||...| .|.|..|...|||||||.. 
ypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwed

GG--------WGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRN------VVTIFSAPNYCYRCGNQAAIMELDDGLkYTFLQFDPA
 |        .| |||||||.||.|. |.| ..|||.|. |.|. |.|||....|..      ..|.|||||||.|.|| ||....|..| ..| ||||.
dgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdps

PR
| 
ph
subfamily_PPP2C_pd Subfamily PPP2C 11-299 1.4e-191 627.9 In-house 2-290 (290) alignment 
Range on Protein: 11-299
Range on HMM: 2-290/290.0
KELDKWIAKLEDCKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRF
|.|||.|.||..||||||..||.|||||||.||.||||||||||||||||||||||||.|||.||||||||||||.||||||||||||||.||||||||.
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PNRITILRGNHESRQITQVYGFYDECLRKYGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDRG
..||||||||||||||||||||||||||||||.||||||||||||||||||||.|||||||||||||||||.||.||||||||||||.||||||||||||
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPAPRRG
||||||||||||||.||||.||..|||||..||||||||||||.||||||||||||||||||||||||.|||| |||.|||||||||||
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprrg
0049330 Metallo-dependent phosphatases 11-298 2.9e-113 370.9 In-house 15-302 (309) alignment 
Range on Protein: 11-298
Range on HMM: 15-302/309.0
KELDKWIAKLEDCKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRF
. ||..| .|  .|.|.|. ...|..||||.| .|.|..|.. ...|.||.|||..||..|... |  |.....|.||.||||..|.|.. || |||...
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PNRITILRGNHESRQITQVYGFYDECLRKYGnPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPD-DR
|.....||||||.|.....|||.||.||||| ...|..|.|....|||.|...|.|.| ||||||.. .||.||.|.| .|.|..|..||||||||. .|
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

GGWGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPAPRR
 |.. .|||.|..|| .. |.| . |||.|. |.|..|..|| ...|....|.|||||||.|.||..|..|.|..|...||.|.|.|. 
egfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
0053225 Metallo-dependent phosphatases 11-296 4.8e-109 357.1 In-house 7-292 (293) alignment 
Range on Protein: 11-296
Range on HMM: 7-292/293.0
KELDKWIAKLEDCKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRF
  ||..|  |  .|.| |. .. |...|||.|..|.|..|.. ...|.||.||...||..|... |  |.....|.||.||||..|.|.. || |||...
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PNRITILRGNHESRQITQVYGFYDECLRKYGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDRG
|.....||||||.......|||.||.|||||. ..|....|....|||.||..|.|.. ||||||....||.||...| ...|.||...||||||||.. 
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

GWGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPAP
||..|.||.|..|| .. ..| ..|||.|. |.||.|..|| ...|...||.||||||..|.||..|...||.||...| .|.| .
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP4C_pd Subfamily PPP4C 12-296 5e-150 491.5 In-house 2-286 (288) alignment 
Range on Protein: 12-296
Range on HMM: 2-286/288.0
ELDKWIAKLEDCKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFP
.||. |.||..|. ..|..||.||.||.|.| .|||||.|..|||||||.||||.||.|||..||. |.|||||.||.||||.|||||  ||.|||||.|
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

NRITILRGNHESRQITQVYGFYDECLRKYGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDRGG
.|||..||||||||||||||||||||||||. |||.| |..||||.|.|..||.|||.||||||||.|||.|||.|| ||||||||.||||||||.|  |
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPAP
|..||||||| ||.|..|.||..|...|..||||||||||..  ...|.|..||||||||||| |||.|||. |.. |  |. |.
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP6C_pd Subfamily PPP6C 12-293 3e-139 456.1 In-house 1-282 (290) alignment 
Range on Protein: 12-293
Range on HMM: 1-282/290.0
ELDKWIAKLEDCKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFP
||||||   ..|| | ||..|.||.. ..||..||||| |..|||||||.||||.||.|||| ||. |||.|.|.||.|||||||.||...|..||...|
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

NRITILRGNHESRQITQVYGFYDECLRKYGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDRGG
.|||.|||||||||||||||||||||.|||| |.|||.|..|| |...|..|.|..|.|||||| . |||.|| ..| ||.||.|..|||.||||.|   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFD
| .||||||| ||. ....|.|.| | |..||||||.||...  | ..||..||||||||||| |.|..|.|  . ..  |.
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_PPG1_pd Subfamily PPG1 13-297 8.4e-132 432.0 In-house 1-298 (300) alignment 
Range on Protein: 13-297
Range on HMM: 1-298/300.0
LDKWIAKLEDCKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPN
||. . ||. .. | |  ||.|..| |||| .||||.|...|||| |||||||.|..|.|.|||. |||||||.|||||||.|||||.|||..||.|.| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITILRGNHESRQITQVYGFYDECLRKY-GNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPD----
|||.||||||||||||||||| |||||| ||..||||.|..|||| |.|..| .|.|.|||||||. ..| |. |||..|||.|| ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DRGG--WGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPAPR
      || |  . .|.|||||..|.|. |.| .|| .  . |||||..|||.   |  . |..|||||||||||.|.|.|| . ... |  .. ||.
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_PPP5C_pd Subfamily PPP5C 13-294 3.1e-85 279.0 In-house 21-308 (322) alignment 
Range on Protein: 13-294
Range on HMM: 21-308/322.0
LDKWIAKLEDCKQLEENNVKNLCEKAKELLSQESNVQEVKCP----VTVCGDVHGQFHDLMELFRIGGK-SPDTNYLFMGDYVDRGYYSVETVSLLVALK
... . .... |.|..  . ..  .|||||.... . |.. .    .|||||.||||.||...|.. |. |..  ||| ||.|||| .|||.. .|...|
vkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfk

VRFPNRITILRGNHESRQITQVYGFYDECLRKYGNpNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSI-DTLDHIRSLDRLQEVPHEGPMCDLLWSDP
. .||.. . |||||| .. ..||| .|.  || . .| . ||..|..|||. ... ... .||||  .   |||..| .|| .. |.|| ...||||||
llyPnhfflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdp

DDRGGWGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL-DDGLKYTFLQFDP
... | . | || | .|| |....| ..|.|.|. |.|.. .|||.  || ...|.||||||| . ||..|...| .| || .| .|. 
qeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfea
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 17-296 7.9e-100 326.7 In-house 15-295 (298) alignment 
Range on Protein: 17-296
Range on HMM: 15-295/298.0
IAKLEDCKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITI
... . .|...|..|..|.|.||..... . . ||. |..||||.|||. ||. ||  .|  ||.||||.||||||| ...|.. ||.| ||..||.. .
lsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffl

LRGNHESRQITQVYGFYDECLRKYGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDD-RGGWGIS
||||||  .| .|||||.|| |.| . .... | |.|. ||||||. |.|.|.|||||. . .||..|.| | .. ..|    ||||.||..   ||  .
lrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaen

PRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPAP
 ||....||.|  ... ..  . || ||||.| .||..  ....|||||||.|| .  | ||.|..|. |. .|  . |. 
srGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_PPZ_pd Subfamily PPZ 18-294 2.8e-82 269.6 In-house 17-293 (300) alignment 
Range on Protein: 18-294
Range on HMM: 17-293/300.0
AKLEDCKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITIL
||      |..... ..| ||.||.  . .. |.  .| . ||||||. ||. ||   |  | .||||.|||||||  |.||. ||.. |...|. . .|
akrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffll

RGNHESRQITQVYGFYDECLRKyGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDR-GGWGISP
|||||  ..|.|||||||| |.  | ..|| | | |. |||.|.| |.|||.|||||| ....| || . |  .||  | . ||||||| |    |    
rgnhecanvtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewedne

RGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDP
||  | . .   ..|  . |. || ||| .| .||..  ||..||.|||||||    |  |.| . .||  .|  .||
rgvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 22-294 5.7e-67 218.7 In-house 12-288 (290) alignment 
Range on Protein: 22-294
Range on HMM: 12-288/290.0
DCKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNH
  . ...... .. ||..|.|     . ||. |... ||.|||. .|.. |   |. |. ..||.|||||||  |.|   ||  .|.|..... .|||||
vldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnh

ESRQITQVYGFYDECLRKYGnPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDR--LQEVPHEGPMCDLLWSDPDD--RGGWGI-SP
| |.. ..|||..|  || |  ..|| . |.|. |.| | |. .|.|.|||.|. |.. . ...| .   .   .|| . ||||.||.        .   
evrkvnrlygfkeelarkrg.srlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkq

RGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDP
|.    ||..  ... .. .| |. |||..  ||.|.  |...||.|||| |. .  |  ||... . |. ..  . |
raisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_PPP3C_pd Subfamily PPP3C 23-283 4.2e-89 292.4 In-house 38-311 (452) alignment 
Range on Protein: 23-283
Range on HMM: 38-311/452.0
CKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHE
  .|||... .. |.| .||..|... ||. |.||.||.||||.||..|| .||.  .|.|||.||||||||.|.|.|  | |||. .|... .||||||
egrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhe

SRQITQVYGFYDECLRKYGNpNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDRGGWGI--------
.| .|. . | .||  ||.. .|.. ... || |||.||...| .|.|||||| | .|| |..|||..|.|. ||.|||||||| .. |           
crhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpn

SPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHD------RNVVTIFSAPNYCYRCGNQAAIMELDD
|.||  | ..   . .| ..| |  . |||.   .||.  ..        ..|.||||||.    |.||......
svrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 23-295 1.3e-87 286.5 In-house 5-275 (280) alignment 
Range on Protein: 23-295
Range on HMM: 5-275/280.0
CkqLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHE
|  ..| ..... || |..|. .. . ||..||.||||.|||. ||. ||   .  ||.||||.||||||| . .| . ||.| |||.||.. |||||||
c..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhe

SRQITQVYGFYDECLRKYGNpNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPD-DRGGWGISPRGAGY
  .| . |||.||. |.| . .... | .|.| |||.||| |.|.|.|||||. . .||... | |  . ..|    ||||.||. .  ||. ..||. .
visinrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsv

TFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPA
 ||...  .. .   . |. | ||.| .||..  |...||.||||.|.    |.||.. .|..|. .|  . ||
ifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 23-293 1.6e-84 276.7 In-house 4-281 (284) alignment 
Range on Protein: 23-293
Range on HMM: 4-281/284.0
CKQ-LEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKS------PDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRIT
|.. |.|... .|| .|.||. .|.  .|...||...||.|||| ||. |. . |         ...|||.||||||| .|.| ..|| |.|...|....
cqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvf

ILRGNHESRQITQVYGFYDECLRKYGNpNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDR-GGWGI
.|||||||| . . |||| || ..| . .... |   |  .||.|.|. .|.|.|||.|  .  |. .  |.|  ..|  | ..|| |.||. .  |.  
llrgnhesrpvnmqygfyleckkryse.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyke

SPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFD
|||||| .||..  ..|...  | || ||||.||.||..  ||..||||||| || .  | ||....|. |  .|  . 
sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 23-292 5.6e-78 255.2 In-house 20-292 (297) alignment 
Range on Protein: 23-292
Range on HMM: 20-292/297.0
CKQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHE
.| . |. | .| . | ... .. .. ||..|. ||||.|||| ||. ||. ||  | .||||.||||||| .|.||. ||.| ||.||  . .||||||
skviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhe

SRQITQVYGFYDECLRKYGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSP---SIDTLDHIRSLDRLQEVpHEGPMCDLLWSDPD-DRGGWGISPRG
   . .|||||.|| ..|    ..  | |.|..|||| |.  .|.|.||||||      ||| .| ..| .|  .|. ..||||.||     |.    ||
cefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrg

AGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQF
||  ||.|   .   .  | || ||||.| .||..   |..||||||| || .  | ||.|  |. |. .|  .
agcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeil
subfamily_PPP1C_pd Subfamily PPP1C 24-292 1.2e-105 345.8 In-house 8-276 (282) alignment 
Range on Protein: 24-292
Range on HMM: 8-276/282.0
KQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHES
 .|.|.....|..||.|.| ... . |.. ||...||.|||..||. || ..|  |..||||.|||||||  |.||. ||.|.|...|... .|||||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

RQITQVYGFYDECLRKYGNPnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYT
 .|...||||||| |.|..  .|| ||| |..|||.|||| .|.|.||||||... |..||.. |  |||..| .|||||||||. . ||. . ||  .|
asinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsft

FGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQF
||.|. |.| ..| | |. ||||.| .||..  .|..||.||||||| . .|..|....|. |. .|  .
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqil
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 24-298 1.6e-89 293.1 In-house 22-297 (299) alignment 
Range on Protein: 24-298
Range on HMM: 22-297/299.0
KQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHES
| ..|.....||. ||. . ... . ||. |. ||||.|||. ||. .| . |  ||.|.||.|||||||   .|...||.. |...|.|. .|||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RQITQVYGFYDECLRKYGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYT
  | .|||||.|| ..|    .|  | | |...||| |. ..|.|.|||||| ..||| .| | | |. |      ||||.|||.   .|    ||  | 
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPAPRR
||||. ..  .. .. ||.||||.| .||..  ....||||||| || .  | ||||..|. |  ||  . |.|..
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 24-294 1.5e-75 246.8 In-house 8-281 (287) alignment 
Range on Protein: 24-294
Range on HMM: 8-281/287.0
KQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHES
. ...... .. ||..|.|   . . ||. |.|..||.|||..||. .|   |..|...|||.|||||||  |.| . || .||...|... .|||||| 
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

RQITQVYGFYDECLRKYGnPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQE--VPHEGPMCDLLWSDPDDRgGWGIS---PRG
..| ..|||..|  ||..  ...| | |.|..||| | |. .|.|.|||.|| ...|| ...| . .     .|| . ||||.||.     ..     |.
kkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkira

AGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDP
    ||.   ... .. .. |. |||... |||..  |...||.|||| |. .  | .|.. ... |. .| .. |
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 24-286 1.6e-58 191.3 In-house 5-292 (302) alignment 
Range on Protein: 24-286
Range on HMM: 5-292/302.0
KQLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVSLLVALKVRFPN
|.......  |.|.  |||..|... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. |||| .|.
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

RITILRGNHESRQITQVYGFYDECLRKYGNPN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDR-LQEVPHEGPMCDLLWSDPDD
.  .||||||.. |   ||| .|   ..|. .   .|. | . | ..||.|||  .|.|.|||.|| ...|..|....| |.|| ..    |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

RGGWGISPRGAGYTFG--QDISENFN--------HNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLK
  .  . ..   |..   ...|  ||        .. .| |. |||| . ||...  |....||||||.|     |. |....|   |
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 24-76 2.7e-13 42.8 In-house 6-59 (317) alignment 
Range on Protein: 24-76
Range on HMM: 6-59/317.0
KQ-LEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGG
.. ..|... .|| .|.||. .|    |...|||..||.||||.||. |. . |
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 25-286 1.1e-58 191.8 In-house 5-291 (302) alignment 
Range on Protein: 25-286
Range on HMM: 5-291/302.0
QLEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNR
.......  |.|.  |||..|... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. |||| .|..
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

ITILRGNHESRQITQVYGFYDECLRKYGNPN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDR-LQEVPHEGPMCDLLWSDPDDR
  .||||||.. |   ||| .|   ..|. .   .|. | . | ..||.|||  .|.|.|||.|| ...|..|....| |.|| ..    |||..|| | 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

GGWGISPRGAGYTFG--QDISENFN--------HNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLK
 .  . ..   |..   ...|  ||        .. .| |. |||| . ||...  |....||||||.|     |. |....|   |
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngk
PPP_3 26-292 2.7e-119 390.1 In-house 2-269 (271) alignment 
Range on Protein: 26-292
Range on HMM: 2-269/271.0
LEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQ
|.||..|.|..|.||.|..|||..|.. |||||||.|||..||.|||..||.||.|.|||.|||||||..|.|.. ||.|||...|.....|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGYTFG
|..||||..|.|.|.|. .|.|.....|..|||.||.|......||||||||..||.|..|.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQF
.|..|.|...| |.|. |||.|..|||. .||..|||.|||||||.|..|..||..|.. |...| |.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 26-297 5e-81 265.0 In-house 8-279 (281) alignment 
Range on Protein: 26-297
Range on HMM: 8-279/281.0
LEENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQ
. .....|.  ... ..|.|... |.. |..| ||.|.||.|| .|| . |. |.. ..|.|||||||  |.|.. || .||.|...|| .||||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

ITQVYGFYDECLRKYGNpNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTFG
. ..|||| ||  |||  ..|  |   |. ||..||.. .. |.|||||| . .||..|   .  . .. | . ||||.|||... .|  | ||...|||
vnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

QDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPAPR
... ..   . .. |. ||||.|..||.    |...|.||.||||    | ||.. .|. |. ..... ||. 
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
PPP_1 27-281 1.4e-117 384.6 In-house 2-264 (264) alignment 
Range on Protein: 27-281
Range on HMM: 2-264/264.0
EENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQI
||.....|..|.||||..|.|..||. ..|||||.||||.||..||..||.||.|||||.|||||||..|||.. ||.|||...|.....|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|... ...|..||.||.|||.||.|..|...||||||..|.||.|| ..| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL
|||.||.|..|.|...|.|.|. |||....|||.....|.|||||||.||.....|..|...|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PP2Ac_SM00156 27-295 2.3e-111 364.1 In-house 2-270 (271) alignment 
Range on Protein: 27-295
Range on HMM: 2-270/271.0
EENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQI
....|..|.|..||.|.||.|. ||. ||||.||.|||..||..|.. .|..|...|.|.|||||||..|.|...||.|||...|.....|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGYTFGQ
...|||..|. ||| . .... |...|..|||.|||| .|.|.||||||.. .||.||.|.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPA
|. ..| ..| | |. |||..|.|||....|...||||||||||....|.||.......|| .. |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 28-294 9.8e-74 241.3 In-house 5-273 (284) alignment 
Range on Protein: 28-294
Range on HMM: 5-273/284.0
ENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQIT
 ..|. |  .| ... ..  . ||. |. .|||.|||| ||. ||   |    .||||.||||||| . .||. ||.| || |||.. .||||||   | 
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

QVYGFYDECLRKYGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGYTFGQ
..||||.|| |.| .| |.. |  .|  .||||||  .|.|.|||.|  .. . ..|.. |  . |    .  |.||||| . . ||    ||  | || 
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgs

DISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDP
|   ..     . || ||||.| .||..  .| .||||||| || .  | ||.| ..  |  .|. . |
dalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 28-298 7.8e-67 218.6 In-house 22-295 (307) alignment 
Range on Protein: 28-298
Range on HMM: 22-295/307.0
ENNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQIT
 ....|.  .|. ..| |  . ..  |. | ||.|||| ||...| . |. |.| |.| |||||||  |.|.. ||.. |. .|. | .||||||  .. 
keefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvn

QVYGFYDECLRK---YGNpNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTF
. ||||.||.      |. ..|  |   |. ||..||.  .|.|.||||||..  || .|   .    |  | . |.||.|||     |  | ||.|.||
kkygfyeecvtsipkcge.eiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftf

GQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPAPRR
| .. ..  .  |. |. ||||....||     |...|||||| ||    |  ... .|. |    . | |.   
gtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesen
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 29-76 4.1e-08 25.7 In-house 14-61 (339) alignment 
Range on Protein: 29-76
Range on HMM: 14-61/339.0
NNVKNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGG
 .. .|| .|.||.  |  . ....|. | ||.|||| ||. .. . |
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_PPPLV_pd Subfamily PPPLV 32-281 1e-53 175.6 In-house 3-275 (290) alignment 
Range on Protein: 32-281
Range on HMM: 3-275/290.0
KNLCEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLM----ELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQIT
  ||..| . | .| .. |.| |. | ||.||...||.     |.|.| .   ...||.||||||| .||| .. |.|||| .| .. .|||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGNP--NVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSL----DRLQEVPHEGPM-CDLLWSDPDDR-----------
. . .. |.  |.|.   .||. |.. ||.|||.| .| ..|| |.|.  .| |  .| ..    .||..  .  |.  |.|||||..            
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GGWGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRcGNQAAIMEL
  |    . || |. |..|  |.| ..|.|  | |||.   .|..  ..  ..|.||. .||    |.||.. .
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilv
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 35-296 4.6e-69 226.0 In-house 15-276 (280) alignment 
Range on Protein: 35-296
Range on HMM: 15-276/280.0
CEKAKELLSQESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQITQVYGFYD
    . .. .|||. | ..|. | ||.| |..|.  || . |. |. . .|.|||||||   .| . ||..||.|. .|| .||||||.  . ..|||| 
irmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyv

ECLRKYGNPnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTFGQDISENFNH
||  |||   .|  |   |. .|...|.  ...|.|||||| .  || || . |  |    | . ||||||| ..| ||  | ||  | ||. . |.  .
ecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqack

NNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPAP
.  . |. ||||.| .||.    | ..|.|| |||| .  | ||.. |.  |. .| |. | |
sleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 49-294 4.7e-58 189.9 In-house 3-255 (263) alignment 
Range on Protein: 49-294
Range on HMM: 3-255/263.0
QEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQITQVYGFYDECLRKYGNPN----
 |...|. .||| |||. ||. .|   | .  |.|||.||||||| .|.| . ||..||. .| .. .|||||| . | . |||. |  ...   .    
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGYTFGQDISENFNHNNGLTLV
|...| ..| |.|| |.|  .|.|.|||.|| . .|| ||..    |  .  |. |||||.||.     |. |   |     ||.   ... .   . |.
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidli

SRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDP
 ||||.|  || .  || ..|.|||  |     | ||.. ..  |. .|.|. |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
Metallophos Calcineurin-like phosphoesterase 54-246 5.6e-45 147.1 Pfam-A 2-198 (200) alignment 
Range on Protein: 54-246
Range on HMM: 2-198/200.0
PVTVCGDVHGQFHDL----MELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLL--VALKVRFPNRITILRGNHESRQITQVYGFYDECL----------
...|.||.||...||    ..|..|..... ...||.||.|||| .| ||  ||   .||...|...  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIrsldrlqevphegpmcdllwsdpddrggwgi
                       ......... .. . |..||| |||||.|.. ||.||.| .. | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYTFGQDISENFNHNNGLTLVSRAHQL
    ... || |  |..  ..|..|| |.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 55-246 3.1e-80 261.6 In-house 1-197 (198) alignment 
Range on Protein: 55-246
Range on HMM: 1-197/198.0
VTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQITQVYGFYDECLRKYGNPNVWKYFTDLFD
||||||.|||..||..||. |..||...|||.|||||||..|.|.. ||.|||...|.....|||||||.....||||..|.|.|.|. .|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQL
.|||.||.|......|||||..|..||.|.. .| .|.|.||...||     |..........  | ||||..||.|..|.. ..| |.|. |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 55-246 7e-76 247.7 In-house 1-196 (197) alignment 
Range on Protein: 55-246
Range on HMM: 1-196/197.0
VTVCGDVHGQFHDL-MELFRIGGKSP-DTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQITQVYGFYDECLRKyGNPNVWKYFTDL
|||.||.|||..|| ..|...||. . ...|.|.|||||||..|.|.. ||.|||...|.....|||||||......|||..|.|.|  . ...|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQL
||.|||.||.|......|||||.....||.|. ..| .|.| .|. ..|| |||||  .  |.  | ||||..||.|. |.| ..|.| |. |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 55-246 8e-75 244.2 In-house 1-198 (199) alignment 
Range on Protein: 55-246
Range on HMM: 1-198/199.0
VTVCGDVHGQFHDL-MELFRIG-GKSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQITQVYGFYDECLRKYGNPNVWKYFTDL
||||||.|||..|| ..||. |  .|....|.|.|||||||..|.|.. ||.|||...|.....||||||..|....|||..|.|.||.. ...|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRSLDRLQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQL
||.|||.||.|......||||||.|....... ..| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| ..|.| |. |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 55-127 3.4e-09 29.5 In-house 12-80 (235) alignment 
Range on Protein: 55-127
Range on HMM: 12-80/235.0
VTVCGDVHGQFHDLMELFR--IGGKSPDTNYLFMGDYVDRGYYSVETVSLLvalkvrFPNRITILRGNHESRQIT
. | ||||| . .|.||.   |||| ..   ...|| ...|  |||.||..        .    ..||||   . 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 80-295 1.2e-72 237.8 In-house 100-315 (317) alignment 
Range on Protein: 80-295
Range on HMM: 100-315/317.0
DTNYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQITQVYGFYDECLRKYGNpNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDT
  .|||.||||||| .|.| |.||.|||...|.....|||||||| . . |||| |. ..| . .... |   |  |||.|.|. .|.|.|||.| ..  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelld

LDHIRSLDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAI
|. .  |.|  ..|  | ..|| |.||| .  |.  |.||||  ||..  ..|...  | || ||||.|..||..  ||..|||||||.|| .  | ||.
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

MELDDGLKYTFLQFDPA
...|. || ..  . | 
lsvdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 82-297 3.3e-56 183.8 In-house 121-336 (339) alignment 
Range on Protein: 82-297
Range on HMM: 121-336/339.0
NYLFMGDYVDRGYYSVETVSLLVALKVRFPNRITILRGNHESRQITQVYGFYDECLRKYgNPNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLD
 |||.||||||| .|.| | || |||. .|.|| .|||||||| .   |||| |   .| . .... | ..|. .|. |...  |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

HIRSLDRLQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIME
..  . |  |.|  | . || |.|||    |.  | ||| . ||      | ..  | .| | ||.| .||..   | .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDDGLKYTFLQFDPAPR
.|  || .   | |  |
idkklkisinvfrpesr
subfamily_PPP7C_pd Subfamily PPP7C 198-295 3.2e-22 71.8 In-house 237-335 (383) alignment 
Range on Protein: 198-295
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGYTFGQDISENFNHNNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDGLKYTFLQFDPA
. |.|||||   .| .  . ||.|  || |..... .. .|.|. |.|.  .|||...||..|.||||| ||     |. | . | . |.  ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas