Gene PPP3C-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP177_AA protein Get Run
AqueP177_AA_66-349 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 32-88 2.8e-11 36.0 In-house 16-72 (298) alignment 
Range on Protein: 32-88
Range on HMM: 16-72/298.0
QEASNYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSY
.|..  | .. . |. |||.| |.||. ..|. . ||| | ||||||. ||. .|. 
sekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdk
subfamily_PPP4C_pd Subfamily PPP4C 34-89 1.6e-08 27.2 In-house 10-65 (288) alignment 
Range on Protein: 34-89
Range on HMM: 10-65/288.0
ASNYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
  . .|.. ..|. | ..| ... .|  . |. .|..| ||||||| ||...|  .
lrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvg
subfamily_PPP6C_pd Subfamily PPP6C 34-88 1.4e-07 23.9 In-house 9-63 (290) alignment 
Range on Protein: 34-88
Range on HMM: 9-63/290.0
ASNYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSY
|.. | |  . .. | .   .|. .| ..  .|.|. | ||||||| ||...|  
akkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrt
0045823 Metallo-dependent phosphatases 36-402 8.8e-87 284.7 In-house 39-322 (473) alignment 
Range on Protein: 36-402
Range on HMM: 39-322/473.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNsehlirregaattsqdiptdpshkeeegscppsqvscpplptlin
. .||. . .  |..|| ...| | .||.||..||||||||||. ||  ..   .                                             
kegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekig.............................................

gyysfdpkplqghnsikKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSYaeginFAEECQSKYGEETYESFMRCFDS
                  |..  ..||||.|||| .| |....|||||..||...|.||||||.| ...        | .|.  ||||. || |.....|
.................fppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglyg.....fgdetlekygedlyeeflewlrs

LPLAAIVeNKfgKWLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRmsdkdyqeFLEIDYLPNPPRGCSCFYGYLAITPFLNN
|||||.. ..  |.|..|||. . ...|  |...||. |.| .|...|| ||||  .|. | .        .| . . .| |||.....|. |.  ||..
lPlaavi.gg..kilfvHGGlspdlplldqireierpleipddgllldllwsdP..weddgdg........llrlrffgnsprgagylFgpdaveeflkk

NDLLGIIRAHQCKEEGIGYAYTNNRkelFPFPLVTTLFSASNYCGSYTNKGAILLIYTDDIKVIKYR
|.|  |.|.|.. .||. . . ...   . .. . |.|||.|||| . |..|.|.|  | |..| ..
ngldlivrGHthvpeGyellfdgkv...igiDtgiTvfSApnYcgrggnlaAvlvidedlisfiqfd
0049330 Metallo-dependent phosphatases 36-398 2.2e-75 246.7 In-house 26-292 (309) alignment 
Range on Protein: 36-398
Range on HMM: 26-292/309.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEhlirregaattsqdiptdpshkeeegscppsqvscpplptlin
..|||. . .  |...| ...|.| .||.||..||||||||||. ||  ..   .                                             
klkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfp...........................................

gyysfdpkplqghnsikkPHsPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSYaeginFAEECQSKYGEETYESFMRCFDS
                  |    ..||||.|||| .| |..|.|||||..||...|.||||||.| ....       | .|.. |||.| .| |.....|
..................pe.drlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrllnglyg.....fgdetlrkygaelweefldwlrs

LPLAAIVENkfgKWLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPLLEEVLgrrmsdkdyqefleidYLPNPpRGCSCFYGYLAITPFLNN
|||||....   |.||.|||. . ...|..|..|||. |.|| |..|||.||||| .                   ..||| ||.....|. |.  ||. 
lplaavigg...kilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpireg................fapnp.rglgvvfghtaverflkk

NDLLGIIRAHQCKEEGIGYAYTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDIKV
|.|  |||.|.. ..|. . . ..         . |.|||.|||| . |.||.|.|  |   .
ngldliirghgavfgGyltffdgk.........litvfsapnycgrlgnlgavleidedlvis
0053225 Metallo-dependent phosphatases 36-394 1.1e-69 228.1 In-house 18-280 (293) alignment 
Range on Protein: 36-394
Range on HMM: 18-280/293.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEhlirregaattsqdiptdpshkeeegscppsqvscpplptlin
..|||  . .  |..|| ...| | .||.||..|.|||||||.. ||  .. . .                                             
llkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfp...........................................

gyysfdpkplqghnsikkPHsPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSYaeginFAEECQSKY-GEETYESFMRCFD
                  |    ..||||.|||| .| |....|||||. ||.....||||||.. ....       | .|.  || ..| .. ......
..................pe.drlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmllnglyg.....fgdetlrkygaaelwdelldwlr

SLPLAAIVENkfgKWLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsdkdyqeFLEIDYLPNpPRGCSCFYGYLAITPFLN
||||||....   |.|..|||.   . .|..|....|. ..|| |...|| ||||                 .|  ..||. .||.....|. |.  ||.
slplaaligg...kilfvHgGlspdlslldqireinrplriplegllldllwsdp.................dlwsgwlps.yrglgvvfghtavlrflk

NNDLLGIIRAHQCKEEGIGYAYTnnrkelfpfPLVTTLFSASNYCGSYTNKGAILLIYTD
.|.|  |||.||.  .|. . .          . . |.|||.||.| ..|.||.| . ..
kngldliirghqvvpdgylpwfd.........gklvtvfsapnylgrlgnlgavlaldeg
subfamily_PPP2C_pd Subfamily PPP2C 36-87 8.4e-09 28.0 In-house 13-64 (290) alignment 
Range on Protein: 36-87
Range on HMM: 13-64/290.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
. | || |.|. |.|.| .... |. .  ...|. |.||.|||| ||...| 
eckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 37-393 8.2e-56 182.5 In-house 6-303 (317) alignment 
Range on Protein: 37-393
Range on HMM: 6-303/317.0
YKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEHLIRRegaattsqdiptdpshkeeegscppS-QVSCPPLPTLIN
 .|.... .  |   | .||  |.  |.| ||. ..||||||| ||. ..      .   .                         . . .   |.   .
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwplssqe.........................eksepkslllessk

GYYSFDPKPLQgHNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYAeginFAEECQSKYGEETYESFMRCFDS
   .  . ..   |  ..     ||||||||||| .| | ...|.|||..|| . |.|||||||| . . .|     | .|.. .| .. ||.|   |  
dvkqtvaavks.vnkevtkgykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvnt.qyG....fyrevkkrysaalyeafqlafnv

LPLAAIVENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsD---KDYQEfleidylpnPPRGCSCFYGYLAITPF
|||.|.|..|    || ||||  .. .|  .. |.|  . |  |  .|| |.||           |   | |.|          .|| .  .|  |.  |
lplcavvnkki...lcmhGGiseelldlkqldklkrpldipdvGvladltwadp...........daevkgyke.........sarGagkvfGakavkef

LNNNDLLGIIRAHQCKEEGigYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLIYT
|.. ||  ..||||  |.|  | . ..||      || |.||| .|||   | .|.| . .
lkkldldlvvrahqvvedG..yeffadrk......lv.tifsapsycGqldniaavlsvdk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 38-394 4.1e-50 163.8 In-house 6-272 (284) alignment 
Range on Protein: 38-394
Range on HMM: 6-272/284.0
KLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEHLIRREGAattsqdiptdpshkeeegscppsqvscpplptlingy
|||..  .  |   | .||  |.  | . ||. ..||||||| ||. ..      .   ..                                       
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeake.....................................

ysfdpkplqghnsikkphsPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKYGEETYESFMRCFDSLP
                     ||||||||||| .| | |..|.|.|. .| . |.|||||||| . .  |     | .||. .| |  ||.|  .| ..|
...................kkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnm.qy....gfyleckkrysealyeafqlafnamp

LAAIVENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKdyqeflEIDYLPNPPRGCSCFYGYLAITPFLNNND
|.|.|..|    .| ||||  .. .|  .. |||  . |  |  .|| |.||           ..      |...  . |||.   .|  |.  ||.. .
lcavvskki...icmhggisedlldlkqldklerpidipdigviadltwadp...........ea......evegykesprgagkvfgakavkeflkkfk

LLGIIRAHQCKEEGigYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLIYTD
|  ..||||   .|  | .  .||      || |.|||  ||| . | .|.| . ..
ldlvvrahqvvmdg..yeffadrk......lv.tifsapsycgqldniaavlnvdee
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 38-87 1.2e-07 24.3 In-house 21-70 (297) alignment 
Range on Protein: 38-87
Range on HMM: 21-70/297.0
KLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
|..    |  |.. | ..|| ..... . ||| | ||||||| ||. .| 
kviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfh
subfamily_PPG1_pd Subfamily PPG1 38-87 5e-07 22.2 In-house 12-61 (300) alignment 
Range on Protein: 38-87
Range on HMM: 12-61/300.0
KLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
.||  ..|. |..   .|. .|  . .. .|. |.||.|||| |...|| 
ellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifk
subfamily_PPP1C_pd Subfamily PPP1C 39-90 2.2e-11 36.5 In-house 9-60 (282) alignment 
Range on Protein: 39-90
Range on HMM: 9-60/282.0
LLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTN
 |... .. |...| ...... .||.|.||. ..||||||. ||. .|....
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsg
subfamily_PPP3C_pd Subfamily PPP3C 40-404 5.9e-139 456.7 In-house 41-322 (452) alignment 
Range on Protein: 40-404
Range on HMM: 41-322/452.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSytnsehlirregaattsqdiptdpshkeeegscppsqvscpplptlINGyys
||..... .||||.||.|.|.|||...|||.|||||||||.||...|.                                              ..|   
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfe..............................................vgG...

fdpkplqghnsikKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsyaegINFAEECQSKYGEETYESFMRCFDSLPLA
             .|.|..|||||||||||..|.||.|.|.|||.||||..|.||||||.|..|..     ..|.|||..||.||.|...|..|||||||
.............dPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhltey.....ftfkeeckikyseevydacmesfdslPla

AIVENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPLleevlgrrmsdKDYQEFL-EIDYLPNPPRGCSCFYGYLAITPFLNNNDL
|.....|   ||.|||....||||..|..|.|||||| |||.|||.|||||           .||.|.  | ...||..||||.||.| |...||..|||
allnqqf...lcvhGGlspeikslddikkldrfkeppasGplcdllWsdPl...........edygeekteekfvpnsvrGcsyfysykavceflqkndl

LGIIRAHQCKEEGigyaYTNNRK-ELFPFPLVTTLFSASNYCGSYTNKGAILLIYTDDIKVIKYRSG
|.|||||.....|    |...|| |...||...|||||.||...|.||.|.| ............| 
lsiiraheaqdaG....yrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvmnirqfnss
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 40-93 1.1e-11 37.4 In-house 6-59 (302) alignment 
Range on Protein: 40-93
Range on HMM: 6-59/302.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEH
...| .  |||.  .|.| |.|| ..|.|. ..||||||| ||| |. . .|..
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvske
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 40-93 1.2e-11 37.4 In-house 7-60 (302) alignment 
Range on Protein: 40-93
Range on HMM: 7-60/302.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEH
...| .  |||.  .|.| |.|| ..|.|. ..||||||| ||| |. . .|..
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvske
PPP_3 40-89 1.8e-10 33.3 In-house 2-51 (271) alignment 
Range on Protein: 40-89
Range on HMM: 2-51/271.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
|. .... |.... .... |..|...|||..|.||||||. ||. .|...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfkng
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 41-89 2.3e-06 20.2 In-house 4-52 (284) alignment 
Range on Protein: 41-89
Range on HMM: 4-52/284.0
ERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
    |. |. .| ..|. .  |.   .|| . ||||||| ||. .|   
ppedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkn
PP2Ac_SM00156 42-394 7.4e-77 251.0 In-house 3-259 (271) alignment 
Range on Protein: 42-394
Range on HMM: 3-259/271.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFsytnsehlirregaattsqdiptdpshkeeegscppsqvscpplptlingyysfd
.. |  |.||. ...| |..|...|||..|.||||||. ||. ..                                                       
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll.......................................................

pkplqghNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqfsyaEGINFAEECQSKYGEETYESFMRCFDSLPLAAI
       .. ..|..  |.||||||||| .| |.||.|.|||..||.....|||||||. ..     .   | ||.. |||.|.|| |...|..|||||.
.......elageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn.....kiygfeeevkrkygkeiyekfeeafsllPlaal

VENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsdkdyqEFLEIDYLPNPpRGCSCFYGYLAITPFLNNNDLLGI
|..|.   || |||. ....|| .|..|.|.||.| .|...||.||||                |  | .. |.  ||.|...|  |.. ||..|.|  |
vdski...lcmhGGlspeleslddirklkrvkekpeegllidllwsdp................eqkekgfqpsk.rglsvvFgedavkeflkknnlkli

IRAHQCKEEGigYAYTNNRkelfpfpLVTTLFSASNYCGSYTNKGAILLIYTD
||||....||  | .  ..        . |.|||.|||....||.|.| ....
iRahevvdeG..yeffadk.......klvtifsapnycdefsnkaavlkvekn
PPP_1 42-89 3e-09 29.5 In-house 3-50 (264) alignment 
Range on Protein: 42-89
Range on HMM: 3-50/264.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
..... |.... .|.. ||.||..|..| |.||||||| ||. .| ..
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvg
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 42-87 1.3e-08 27.4 In-house 8-53 (280) alignment 
Range on Protein: 42-87
Range on HMM: 8-53/280.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
   ....||.  |... ..|.. . ||. | ||.|||. ||. .|.
eadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfa
subfamily_PPZ_pd Subfamily PPZ 42-87 3.2e-06 19.9 In-house 27-72 (300) alignment 
Range on Protein: 42-87
Range on HMM: 27-72/300.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
 | .  .  .| .||  . .|| || .. ..||.|||..||. .|.
nseilqicikarelflaqpallelspsvkivgdvhgqyadllrlft
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 43-89 2.1e-08 26.8 In-house 27-73 (299) alignment 
Range on Protein: 43-89
Range on HMM: 27-73/299.0
SSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
  .| | . | . | .. .|| . |||.| ||||||. ||. ||. .
qelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdka
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 44-89 7.3e-08 25.0 In-house 12-57 (281) alignment 
Range on Protein: 44-89
Range on HMM: 12-57/281.0
SVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
 .. .| |.  .| .|..|  . .||||.||.|.|| ||  .|   
eienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfell
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 44-87 1.9e-07 23.3 In-house 14-57 (287) alignment 
Range on Protein: 44-87
Range on HMM: 14-57/287.0
SVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
 .  ..|.. ....  ..||.. |||...||||||. ||. || 
dilevlekieeileplpalleveapitivGdihGqlddllrifn
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 45-391 1.6e-45 148.7 In-house 16-320 (339) alignment 
Range on Protein: 45-391
Range on HMM: 16-320/339.0
VQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSyTNSEHLIRREGAATtsQDIPTdpsHKEEEGSCPPSQvscpPLPTLINGYYSFDPkP
.  |   | .|   |  .|.| |||.|.||||||| ||. ..   |   |  .|  |   .||     .  | |  | |.    |  |  .      | |
laelchrareliwsepiflkleapicvmgdihgqfddllamld.mngwplssqefeal..kditv...rsretgkrpqse....phstqpessndvkp.p

LQGHNSIKKPHS---PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqFSYAeginFAEECQSKYGEETYESFMRCFDSLPLAAI
.   .|..|  .     ||||||||||| .| | ...| |||.||| | ..|||||||| .   ||     |  | . .|  . || |   |. .|..|.
vaapksvnkevttgykrylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvn.tsyg....fyrevnyrydaqlyecfqnmfnvfpfcav

VENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrRMSDKDYQefleidylPNpPRGCSCFYGYLAITPFLNNNDLLGI
..|     .| ||||  .. |.  .  ..|  | |  | . || |.||          ..| |.        |   ||.|  .|  |.  ||.. ||  .
innti...mcmhggisehltsfnqfsvfkrpleipdvgvltdltwadp........dptekgyk........ps.argasfvfgppalraflkkldlqmv

IRAHQCKEEGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
|| ||  |.|  | . . |.       . |.||| ||||   |  |.. |
irghqvvedg..yeffdgrr.......lvtifsapnycgqndntaavfsi
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 45-87 1.3e-07 24.1 In-house 25-67 (307) alignment 
Range on Protein: 45-87
Range on HMM: 25-67/307.0
VQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
.. .| ||  .|  | .|. .  | ||.||.|||| ||...| 
fenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfi
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 45-86 9.4e-06 17.8 In-house 21-62 (290) alignment 
Range on Protein: 45-86
Range on HMM: 21-62/290.0
VQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIF
.  ..|.. ....   .||.. ||||..||||||. .|.  |
ileilekieeileplpalleveapivivgdihgqldallryf
Metallophos Calcineurin-like phosphoesterase 68-348 2.4e-28 92.8 Pfam-A 2-199 (200) alignment 
Range on Protein: 68-348
Range on HMM: 2-199/200.0
PIVVIGDIHGQFCDLVdifsytnsehlirregaattsqdiptdpshkeeegscppsqvscpplptlingyysfDpKPLQGHNSIKKPHSPSYLFLGDYVD
.|.||||.||.. ||                                                          |   |. .. ....    .|||||.||
rilvigDlHgglddle.........................................................d.lllillkiaaeekpdlvlflGDlvd

RGCYSSECILFL--LALKVAYPSRFFMLRGNHESRCMTQFSYAEGINFA-----------------------------EECQSKYGEETYESFMRCFDSL
|| .|||..  |  |.||...| ..|.|||||||.........  . .                                   ..| ...| . ..|. |
rgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflal

PLAAIVENKFgkwLCCHGGIGSKIKSLGSIeslerfkepplsgpfcdliwsdplleevlgrrmsdkdyqefleidylpnpprgCSCFYGYLAITPFLNNN
||.|.|..|.   |..||...|  .|   |                                                     .|. .|. |  ..|...
plralvdgki...lltHgplsssggsgddi.....................................................gselfgpdaleklleky

DLLGIIRAHQCK
..  ..|.|..|
gvdlvlrGHtHk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 148-392 4.7e-42 136.9 In-house 56-269 (287) alignment 
Range on Protein: 148-392
Range on HMM: 56-269/287.0
HNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFg
 |.. ..    |||||||||||  | | .|.|..||.||| .  .|||||| . . .  |     | || . |..|. |. |   |. ||| |.|...  
fnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinkl.y....Gfkeelkrkrqerlykqfndvfselplcarvskri.

kwLCCHGGIGSKIKSLGSIESLERFKEPPLS--GPFCDLIWSDPlleevlgrrmsDKDYQEFlEidylPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAH
  || ||||  |.||| |...|.. . |     |   ||.|.||           .|| . | |    .|  |. |  .|   .  .|.. |.  |.|||
..lcmhGGispklksldslkalkkpttplacdeglqvdllwadp...........ekdaktf.e....lnkiraisvvfGkkevddllkkldidlivrah

QCKEEGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIY
. .|||  ||.  ...       . |.|||. |.|  || ||.. . 
evseeG..yaflfdkr.......lvtvfsapyysgedtnlgavvvvs
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 148-392 3.3e-35 114.5 In-house 62-276 (290) alignment 
Range on Protein: 148-392
Range on HMM: 62-276/290.0
HNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFg
 ... .|    .||||||||||  | |  |.|. .|. |. .  .|||||| | . .. |     | ||   | | . .  .   |. |.| | |..|  
fdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrl.y....gfkeelarkrgsrlwkqyqdvfaelslcarvgrki.

kwLCCHGGIGSKIKSLGSIESLERFKEPP--LSGPFCDLIWSDPlleevlgrrMSDKDyqEFLEIdylpNPPRGCSCFYGYLAITPFLNNNDLLGIIRAH
  || ||||  ||.|  |...|.. . |     |   ||.|.||           |||  . ...    |  |. |  .|  ..  .|..  |  |.|||
..lcmhggisqkiesweslkalkkprvpltcdeglqvdllwadp.........trdkd..dtial....nkqraisvvfgkkglddllkklalslivrah

QCKEEGIGYAYtnNRKelfpfplVTTLFSASNYCGSYTNKGAILLIY
. ||||  . .  ..|       . |.|||  |.|  || |||. . 
evkeegfnflf..dkk.......lvtvfsapyysgndtnlgaiatvs
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 150-391 5.9e-39 126.9 In-house 54-261 (280) alignment 
Range on Protein: 150-391
Range on HMM: 54-261/280.0
SIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMtqfsyAEGINFAEECQSKYGEETYESFMRCFDSLPLAAIVEnkfGKW
 .  |    ||||||||||| .  | ||.||| || || .|..||||||   .      .   | .|.. .| .. |. |   .|||||.|.|    |. 
rvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi.....nrkygfkdevkrryslalynefqelldslplvalvs...gri

LCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlGRRMSDkdyqefleidyLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKE
|| |||.  |..||  .  | |  ... .    ||.|.||        ...              . .||.|  .|   .  . .  |.  |.| ||  .
lcmhgglsqklvslddlaelrrpfdsedeclamdllwadp......enkvtg...........waensrgvsvifganvvkdltekldidliarghqvvq

EGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
.|  | .  ..|       . |.||| .|.|...|. |.| .
dg..yeffadkk.......lvtvfsapkylgefdnsaavliv
subfamily_PPP1C_pd Subfamily PPP1C 151-393 2e-56 184.3 In-house 59-267 (282) alignment 
Range on Protein: 151-393
Range on HMM: 59-267/282.0
IKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwL
   | . .|||||||||||  | | |..|||.|. ||...|.|||||||  .... |     | .||. .|. . ...|. .|. |||||.|..|    |
sgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinri.y....GfydeckrrysiklWktftdvfnclPlaalvdeki...l

CCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEevlgrrmsdKDYQEFLEidylpNPpRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEE
|.|||. ...|||  |....|  | | .|  |||.||||  .         |. ... |     |  || |  .|  ... ||..|||  |.||||. |.
cvhGGlspelksleqirkiqrPlevpekgllcdllWsdp..d.........kevlgwse.....nd.rGvsftfgkdvvekflqkndldlivrahqvved

giGYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLIYT
  || . ..|.      || |.|||.||||.. |.||.| . .
..Gyeffakrq......lv.tvfsapnycgefdnagavlsvde
PPP_3 152-396 3.8e-59 192.9 In-house 52-263 (271) alignment 
Range on Protein: 152-396
Range on HMM: 52-263/271.0
KKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQ-SKYGEETYESFMRCFDSLPLAAIVENKFgkwL
..... .||||||||||| .| |..|.|||||. ||.....|||||||| ...  |     | .|.. .|.|...|. ....|. |||||....|.   |
gpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkv.Y....gFkkevlkkkggkkvykklqevFelLplaalidekv...l

CCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIwsdplleevlgrrmsdkDYQEFLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEE
..|||. ..|||| .|..|||..| | .|...||                    ..  . . | | .||.....|  . . ||..|.|  |||||..|||
vvHGGlspsiksldqikklerkievpeegklldll.................lssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkee

giGYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDI
  || .....|       |.|.|||.|||....|.|||| . ... 
..Gyeilhdgk.......vvtvfSapnycerasnagailkleealt
PPP_2 152-348 4.1e-46 150.2 In-house 22-198 (198) alignment 
Range on Protein: 152-348
Range on HMM: 22-198/198.0
KKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQ-SKYGEETYESFMRCFDSLPLAAIVENKFgkwL
..... .||||||||||| .| |..|.|||||. ||.....|||||||. ...  |     | .|.. .|.|...|. ....|. |||||....|.   |
lpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkv.y....gFkkevlkkkggkkvykklqevfelLplaalidekv...l

CCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrMSDKDyqefLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCK
..|||. ..||.| .|.. ||..| | .|...||  ..          .||..     . . | |  ||.....|  ... .|..|.|  |||||..|
vvHGGlseeiklldqikkeerkiespeegklldlleeek.........lsdpk....ekeellansarGagllfgpdvteelleknklkliiRaHevk
PPP_1 153-389 8.1e-61 198.6 In-house 52-262 (264) alignment 
Range on Protein: 153-389
Range on HMM: 52-262/264.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYAeginFAEECQ-SKYGEETYESFMRCFDSLPLAAIVENKFgkwLC
.... .||||||||||| .| |..|.|||||. ||...|.|||||||| .|.  |.    | .|..  ||..| |. .. .|| |||||....|.   |.
pspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkv.yg....FkkEvlkkkyskeiyktltdvFdvLplaalideki...li

CHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDplleevlgrrMSDKDYQEFLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEG
.|||. .....| .|. ..|..| | .|..||| ..|          ....  ..  . .  .| .||.....|. ... ||..|.|  |||||..||||
vHGGlspeldlldqirkerrktevpeegklcdllekd..........vdillsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeG

igYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAIL
  | ....||       |.|.||||||. . .|.||..
..yeflkkrk.......vvtifsasnyyeegsnrgayv
PPP_4 153-348 1.2e-46 152.3 In-house 25-197 (197) alignment 
Range on Protein: 153-348
Range on HMM: 25-197/197.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSyaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCC
.... ||.||||||||| .| |..|.|||||. ||.....|||||||. ....      .| .|...|.|.|... ....|| |||||....|.   |..
pseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnlly.....gfkkevlekhgkeilkklqdvfdllplaalidekv...lvv

HGGIGSKIKSLGSIESLERFKEPP-LSGPFCDL-IWSDPLleevlgrrmsdkDYQEFleidyLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCK
|||. ....|| .|| .||..| |  .. ..|| .||||             . ||      | |  ||.....|. ... ||..|.|  |||.|..|
hgglsdelesldkierierkiespleeekrkdlllwsdpr............eaqeg.....lansvrGagllFgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 153-391 9.8e-44 142.6 In-house 75-280 (298) alignment 
Range on Protein: 153-391
Range on HMM: 75-280/298.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYG-EETYESFMRCFDSLPLAAIVENKFgkwLC
 |..  ||||||||||| .. | |..||| || ||..||.||||||   . .  |     | |||. .|   . |..|   |..|||.|.. ..    ||
fppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainrv.y....Gfyeeckrrykslrlyaefqdvfnalpltaliggri...lc

CHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKDYqefleIDYLPNpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEG
 |||.  |.||| .. .|.| .... .    ||.|.||           ..        .. .|  || |. .|  ..  .|.. |.  ..||||   .|
mhGGlskklksldqlrelkrpfdskeeslaidllwadp...........enav.....kgwaen.srGvsvvfGedvvkdllekldidlvvrahqvvqdG

igYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLI
  | .  ..|      || |.||| .|||...|  |.. .
..yeffaekk......lv.tifsaphycgqfdnsaavmkv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 153-392 2.7e-34 111.9 In-house 54-261 (284) alignment 
Range on Protein: 153-392
Range on HMM: 54-261/284.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLC
 ||   ||||||||||| .  | ||.|.| || .| .|||||||||   . .  |     | |||| .| .   | ||   |  .||.|.| ..    ||
fphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki.y....gfyeecqrrynkpsvyvsfegvfsvmpltalvgqri...lc

CHGGIGSKIKSLGSIESLER-FKEPPLSGPFCDLIWSDPlleevlgrrmsdKDYQEfleiDYLPNpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEE
 |||.   .. .  . ...| | .|       |..||||             ..|.     . ||  || |  .|  |.  .|.  ..  ..||||  ..
mhggvskmlqnvsqlraikrpfdnpepntlaidilwsdp............tnfqk....gwnpn.srgvsyvfgsdalrklldrlqidlvvrahqvvqd

GigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIY
|  | .  ||.       . |.|||  ||| . |  |.. . 
g..yeffanrr.......lvtifsapfycgqfdnaaavmyvn
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 153-289 2.5e-23 75.7 In-house 71-202 (307) alignment 
Range on Protein: 153-289
Range on HMM: 71-202/307.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQ---SKYGEETYESFMRCFDSLPLAAIVENKFgkw
.|    |.| |||||||  | ||||.|.. |..||    .||||||   . .  |     | |||     | ||| .  | |||. ||..|..  |    
rppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk.ky....gfyeecvtsipkcgeeiwalfqrcfnnlpisaliatki...

LCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDP
|| |||.   .  |  .    .    |. |   |..|.||
lcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp
PPP_5_Dcr2 154-348 2e-45 148.2 In-house 25-199 (199) alignment 
Range on Protein: 154-348
Range on HMM: 25-199/199.0
PH-SPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRcmtqfSYAEGINFAEECQSK-YGEETYESFMRCFDSLPLAAIVENKFgkwLC
|  . .|.||||||||| .| |..|.|||||. ||.....||||||..     .  |   | .|..|| .|.. |. . ..|| |||||....|.   |.
pseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEde.....qlneiygftkevlskyhgkkiykilsdvfdwlPlaalidekv...lv

CHGGIGSKIKSLGSIESLERFKEPP-LSGPFCDLI-WSDPLleevlgrrmsdkD----YqefleidyLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAH
.|||. ..|||. ..| .||..| |  .|  .||. ||||             |    .          |  ||.....|. ..  ||..|.|  |||.|
vhgglspeiksiellekierkieipeekgekadlllwsdpr............daqegc........klnseRGagllfgpdvtekfleknnlkliirsh

QCK
..|
elk
subfamily_PPZ_pd Subfamily PPZ 154-391 7.3e-38 123.8 In-house 77-280 (300) alignment 
Range on Protein: 154-391
Range on HMM: 77-280/300.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVEnkfGKWLCCH
| |  |||||||||||  | | ||.||. |. ||  ||.||||||   .|.  |     | .||. .   . ...|.  |..|||||||    || .| |
ppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrv.y....gfydeckrrcnikiwktfvdtfntlplaaiva...gkifcvh

GGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrRMSDKDYQEFlEidylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGig
||.   ..|.  |  . |  . |  |   ||.||||          | .....  |        || |  |  .||  |||.  .  . |||   |.|  
gglspvlnsmdeirhvvrptdvpdfglindllwsdp........tdssnewedn.e........rgvsycynkvainkflnkfgfdlvcrahmvvedg..

YAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLI
| . |.|       || |.||| |||| . | ||.. .
yeffndrs......lv.tvfsapnycgefdnwgavmsv
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 154-391 1.9e-35 115.5 In-house 60-263 (281) alignment 
Range on Protein: 154-391
Range on HMM: 60-263/281.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCH
.    ..|||||||||  | |....|..||..|. | ..||||||   . .  |     | .||. ||||| .  | |||. ||..| ....    || |
vpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnki.y....gfyvecvtkyGeelwalfqrcfnrlpisaliakrv...lcmh

GGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKDYQEFLE-IdylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGi
||.  .. .|  .    .  ...  |   ||.|.||           |.. .|. . .       || |  .|   .     . ..  ||||||   .| 
GGlsPeltaldelrnrpkpirnldrGlviDllwadp...........dnkveewkass.......rGssftfGknvvddvckrleveliirahqvvqdG.

gYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
 |   . ||       . |.||. |||  |.| .|.| .
.yevlsgrk.......litvfsvpnycafyknaaavlkv
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 154-391 4.1e-33 107.9 In-house 76-280 (299) alignment 
Range on Protein: 154-391
Range on HMM: 76-280/299.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGE-ETYESFMRCFDSLPLAAIVEnkfGKWLCC
|    .||||||||||    | | .||. |. || ||||||||||  .. .  |     | |||. .|     .  |  .|. .||. ..    .. || 
ppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrv.y....gfyeecnkrykstrlwsifqdafaampltglig...srilcm

HGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKDYqefleIDYLPNpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGi
|||.  |...|  .  | | ..||      ||.|.||           |.       .|.|.|  || |  .|   ..  ... |.  . ||||  ..| 
hgglspklqtldqlrdltrpqdppnpslgidllwadp...........dqsv.....kdwlan.vrgvsyvfgqdvvadvisrldidlvarahqvvqdg.

gYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
 | .  ..|       . |.|||  ||| . |  ||. .
.yeffaskk.......lvtifsaphycgqfdnsaaimkv
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 154-389 3.2e-31 101.7 In-house 75-279 (297) alignment 
Range on Protein: 154-389
Range on HMM: 75-279/297.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKYGE-ETYESFMRCFDSLPLAAIVENKFgkwLCC
| .  ||||||||||| .| | |..||| || .|. .|.||||||   . .  |     | |||| .|     | .|   |. |||. .. .|    || 
pptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnk.vy....gfyeecqkryqsvrmyaafqdvfnwlpltgliatki...lcm

HGGIGS---KIKSLGSIESLERFKEPpLSGPFCDLIWSDPLleevlgrrmSDkdYQEFLEIDylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKE
|||.     |  .| ..  .|| .|    .  .||.|.||.         |      |.| .      ||. | .|  |.     . .|  . ||||  .
hgglsplltkeftldtlrkiersteg.kerlvadllwadpi.........sg..lsgfmenq......rgagcgfgrdavlklcsefkldlvcrahqvvq

EGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAIL
.|  | .   ||       . |.|||  ||| . |  |..
dg..yeffagrk.......lvtifsaphycgqfdncaafm
subfamily_PPP6C_pd Subfamily PPP6C 156-398 8.9e-47 152.6 In-house 70-277 (290) alignment 
Range on Protein: 156-398
Range on HMM: 70-277/290.0
SpSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLCCHG
. ||.||||.|||| || | .  ||.||. ||.|  .|||||||| .||  |     | .||..|||.  ..  ... || |..|||....    || ||
t.syvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqv.y....gfydeclnkygnanawkyctkvfdlltiaaiideqv...lcvhG

GIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRMSdkdyqefleidylpnpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGY
|. ...| | .|. .|| .| |  |.||||.||||  |.|    .|                |||   ..|    . |...|.|  |.||||  |||. |
glspdvktldqirvieraqeiphkgafcdlvwsdp..edvetwavs................prgagylfgskvtkefvhinnlklicrahqlveeglky

AYTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDIKV
 . ..         . |..|| |||    |  .|| . ... . 
mfdek.........lvtvwsapnycyrcgnvasilaledaeere
subfamily_PPP7C_pd Subfamily PPP7C 156-401 1.4e-29 96.0 In-house 92-332 (383) alignment 
Range on Protein: 156-401
Range on HMM: 92-332/383.0
SPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMtQFSYAeginFAEECQSKY---GEETYESFMRCFDSLPLAAIVENKFgkwLCC
. .|.| ||.||||  | | .| |||| ..||  ... |||||   .    |     |  | .|||   |..  . .   |  ||||.....|    | .
enpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhil.nlryG....fikeveskykvhgkkilrlledvfawlplatlideki...liv

HGGIgSKIKSLGSIESLERFKEPPL-SGPFCDLIwSDPLLEEVLGRRMSDKDYQEFLEIDY---------LPNPPRGCSCFYGYLAITPFLNNNDLLGII
|||| |.. .|  ....|| |   .   |  .   .    .|    ... ..... |.| .          ||  ||  ...|    . .|.. .|  .|
hGGi.sdktdlelldkiersklvsvlrpplkege.eaekekeessvkvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlklli

RAHQCKEEGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDD-IKVIKY
|.|.|| ||  | .. ..|       | |.||||||    .|.|| . . .|   ....|
rsheckpeG..yefvhdkk.......vltifsasnyyeeGsnrGayvklgkdltprivqy
subfamily_PPP5C_pd Subfamily PPP5C 157-398 1.7e-47 155.0 In-house 94-301 (322) alignment 
Range on Protein: 157-398
Range on HMM: 94-301/322.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGI
 .||| ||.|||| .| |.|| ||..|. || .||. ||||||  | .. |     | .|...|| |. .. | . |..|||| ....|.   | .|||.
npylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkl.y....GfegevkakytekvadlftevfnwlPlahvinekv...lvvhGGl

GSKI-KSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRMSDkdyqefleidylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGigYA
 |.   .|  .  ..|...|| .| ...|.||||  .|  || .|                 || .. .|    . ||..|.|  |||.|. ||||  | 
fsedgvtlddlrkidrnaqppeegllvellwsdp..qeanGrspsk................rGvgvqfGpdvtkkflkennleliirshevkeeG..ye

YTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDIKV
 ... |       . |.||| ||| . .||||.. . .|| |.
vehdGk.......litvfsapnycdqmgnkgafitlrgddlkl
subfamily_PPP2C_pd Subfamily PPP2C 157-391 9.4e-47 152.6 In-house 72-272 (290) alignment 
Range on Protein: 157-391
Range on HMM: 72-272/290.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLCCHGG
  ||||||||||| || |.. .| |||| |..|  .|||||||| .||  |     | .||  |||.   .. |   || |||.|.|...    .| |||
tnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqv.y....gfydeclrkygnanvwkyftdlfdylpltalvdeqi...fclhgg

IGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDkDYQEFLEIdylpnpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGYA
.  .|..|  |..|.|..| |  ||.|||.||||           | | . .         |||.   .|      | ..|.|  |.||||   ||  ..
lspsidtldkiraldrlqevphegplcdllwsdp...........d.drggwgis......prgagytfgkdisekfnktngltliarahqlvmegynws

YTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLI
. .|         |.|.||| |||    |..||| .
hdrn.........vvtifsapnycyrcgnqaailel
subfamily_PPP4C_pd Subfamily PPP4C 157-391 1.9e-46 151.6 In-house 71-271 (288) alignment 
Range on Protein: 157-391
Range on HMM: 71-271/288.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLCCHGG
 .||||||.|||| || |..|.|||||| || |  ..||||||| .|| .|     | .|| .|||.   ..  .. || |.||||...|    .| |||
tnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitq.vy....gfydeclrkygsanvwryctevfdylslaaiidgki...fcvhgg

IGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRMSdkdyqefleidylpnpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGYA
.  .|..|  | |..| .| | .||.|||.||||  |.. |  .|                |||   ..|  ... | ..||.  |.||||   ||  . 
lspsistldeirsidrkqevphegplcdllwsdp..edaegwavs................prgagylfgsdvveqfneandielicrahqlvmegyklh

YTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLI
....         | |..|| |||    |. ||| .
fnek.........vltvwsapnycyrcgnvaailel
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 157-391 1e-28 93.7 In-house 35-242 (263) alignment 
Range on Protein: 157-391
Range on HMM: 35-242/263.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYAEGINFAEECQSK-YGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGG
  ||||||||||| .| | |..|..||.| | ....|||||| ... .  |    .. .  | .   |  |. | . |  .||.||| ..    || |||
tqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkaink.nygfhaelkkrfqreevyesvynhfnqvfsymplcaivskri...lcmhgg

IGSKIKSLGSIESLERFKEPPLSGPF-CDLIWSDPlleevlgrrmsDKDYQEFLeidylPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEegIGY
|  ..|||  | ..    |   . |. |||.|.||           .|| . |      ||  |  |  .|   .  . .  |.  |.||||  |   ||
isphlkslddiraiplpletakthplacdllwadp...........ekdakgfe.....pnkiraisnvfgkkevddlckrldidlivrahqvve..ygy

AYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
|.  .|.       . |.|||| |     |  |....
affadrr.......litvfsasryqielcnyaavvvv
subfamily_PPPLV_pd Subfamily PPPLV 158-400 2.3e-47 154.7 In-house 57-284 (290) alignment 
Range on Protein: 158-400
Range on HMM: 57-284/290.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRcmtqfSYAEGINFAEECQSKYG---EETYESFMRCFDSLPLAAIVENKFgkwLCCHG
|.|||||||||| .| | | .|||||| |||....|||||| .     | .| |..  |.. |.|   ||..|.|. .|| |||||....|    .|.|.
sllflgdyvdrgdfsveliayllalkvlypskvlllrgnhele.....svqesieykgegsfkfgdsleevweafnnvfdalplaavidrkv...fcvha

GIGSKIKSLGSIES----LERFKEPPLSGPF-CDLIWSDPlleeVLGRRMSDKDyQEFLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKE
||   |.. . | .    |||.|..    |.  |..||||      .|  | .  .  |.  ...|  || .. ..  |.  ||..|.|  ..|||. ||
gipraimtqayisaiqdilerlkddidgaplaldilwsdp....aedrdlslrg.elvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevke

EGIGYAyTNNRkelfpfplVTTLFSASNYCGSyTNKGAILLIYTDDIKVIK
.|| .  .. |        . |.||.|.|||| .|. |..|.  . ...|.
kGirlq.qkgr........lltvfsssrycGs.sneaalilvdkkklriit
subfamily_PPG1_pd Subfamily PPG1 158-395 4.6e-47 153.7 In-house 70-286 (300) alignment 
Range on Protein: 158-395
Range on HMM: 70-286/300.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKY-GE-ETYESFMRCFDSLPLAAIVENKFgkwLCCHGG
 ||||||||||| || | | .|..||. ||||  .|||||||| .|| .|     |  ||  || |.   .. .   || | ||||....     | |||
nylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitq.vy....gfyteclrkyggnsrvwkylteifdylvlaaiideei...ycvhgg

IGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPLLEEVLGRRMSDKDYQEFLEidylpnPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGYA
.  ...|.  |  |.||.| |  | ..||.||||  ..       |.. |.| .       .||.   ||   .  ||.|||.  ||||||   ||    
lspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvv......sqrgagysygkdvvekflrnndmnriirahqlcnegyqil

YTNnrkelfpfpLVTTLFSASNYCGSYTNKGAILLIYTDD
. |         ...|..|| |||    || .|| .|  |
fdn.........klstvwsapnycyrcgnkasilelyekd
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 158-395 3e-37 121.4 In-house 73-290 (302) alignment 
Range on Protein: 158-395
Range on HMM: 73-290/302.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqFSYAEGINFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGIG
 ..|||||||||  | ||| ...|||| ||... .||||||....  |.|.   .. .    | | | .| |  .|  .||||.| .|    || |||| 
kfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkain.faygfreelenrlgkkdgkeiwekfnevfsfmplaalvgeki...lcvhggis

SKIKSLGSIESLERFKEPPLSGPF-CDLIWSDPLLEEVLGRRMSDKdyqefleiDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEgiGYAY
 |..|| .|....|  .     ..  ||...|||  ..|    .          .|  |  || |  .   |.. . .. .|  |.||||   |  |. .
pklesledikkikrplkevtedslaqdllfadpldvqllaavsekP........kyaknivrglsvvfneaavrdvckrlnlklivrahqmiPe..Gfkf

TNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDD
  ..|       . |.|||..|     ||||.| . |. 
fadkk.......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 158-395 4.1e-37 121.0 In-house 74-291 (302) alignment 
Range on Protein: 158-395
Range on HMM: 74-291/302.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqFSYAEGINFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGIG
 ..|||||||||  | ||| ...|||| ||... .||||||....  |.|.   .. .    | | | .| |  .|  .||||.| .|    || |||| 
kfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkain.faygfreelenrlgkkdgkeiwekfnevfsfmplaalvgeki...lcvhggis

SKIKSLGSIESLERFKEPPLSGPF-CDLIWSDPLLEEVLGRRMSDKdyqefleiDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEgiGYAY
 |..|| .|....|  .   . ..  ||...|||  ..|    .          .|  |  || |  .   |.. . .. .|  |.||||   |  |. .
pklesledikkikrplkevtedslaqdllfadpldvqllaavsekP........kyaknivrglsvvfneaavrdvckrlnlklivrahqmiPe..Gfkf

TNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDD
  ..|       . |.|||..|     ||||.| . |. 
fadkk.......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 159-391 8.5e-28 90.6 In-house 63-261 (280) alignment 
Range on Protein: 159-391
Range on HMM: 63-261/280.0
YLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGIGS
 .|||||||||    | ...|..||. |  | ..||||||. .. .  |     |  ||| |||   .  |  ||. .|..... ..    || |||.  
lmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki.y....gfyvecqykygvglwwdfqscfnrmpmsgliskrv...lcmhgglsp

KIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmSDKDYQEFLEIdylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGigYAYTN
..  | .|  . |  ||   | . ||.||||          ..|    |  |       || | ..|   .    .. ..  ||||||  ..|  |    
elinldtirniprpcepldrgllidllwsdp..........tnkgegwfhsi.......rgisymfgkgvveqacksleidliirahqvvqdg..yemma

NRKelfpfplVTTLFSASNYCGSYTNKGAILLI
 |.       . |.||  |||  .||  |.. .
grr.......litvfsvpnycaqftnaaavvcl
EF-hand_7 EF-hand domain pair 609-652 8.5e-08 22.2 Pfam-A 22-65 (66) alignment 
Range on Protein: 609-652
Range on HMM: 22-65/66.0
LRKHFSQTLLDKVGKQDETQIKLIFQSIDKNNDGQLSMTELQDF
|.... ... ..  .. ....  ||. ||||.||.||..|.  .
LlrllkhlgsplideevrevldyifkeiDkngdGvlsfeEflqa
EF-hand_1 EF hand 629-652 5.1e-07 18.6 Pfam-A 2-25 (29) alignment 
Range on Protein: 629-652
Range on HMM: 2-25/29.0
IKLIFQSIDKNNDGQLSMTELQDF
.| .|. .||..||..|  |....
lkeaFkefDkDgdGkIsfeEfkea
EF-hand_6 EF-hand domain 630-653 1.4e-06 17.7 Pfam-A 3-26 (31) alignment 
Range on Protein: 630-653
Range on HMM: 3-26/31.0
KLIFQSIDKNNDGQLSMTELQDFA
. .|. .||..||...  ||... 
reaFklfDkdgdGkidaeELrkaL
EF-hand_5 EF hand 632-652 3.7e-08 21.8 Pfam-A 4-24 (25) alignment 
Range on Protein: 632-652
Range on HMM: 4-24/25.0
IFQSIDKNNDGQLSMTELQDF
.|. .|||.||..|. ||. .
tFrafDkNgDGkIsreELkrl