Gene PPP3C-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP177_AA protein Get Run
AqueP177_AA_66-349 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 32-88 2.8e-11 36.0 In-house 16-72 (298) alignment
Range on Protein: 32-88
Range on HMM: 16-72/298.0
QEASNYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSY
.|..  | .. . |. |||.| |.||. ..|. . ||| | ||||||. ||. .|. 
sekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdk

subfamily_PPP4C_pd Subfamily PPP4C 34-89 1.6e-08 27.2 In-house 10-65 (288) alignment
Range on Protein: 34-89
Range on HMM: 10-65/288.0
ASNYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
  . .|.. ..|. | ..| ... .|  . |. .|..| ||||||| ||...|  .
lrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvg

subfamily_PPP6C_pd Subfamily PPP6C 34-88 1.4e-07 23.9 In-house 9-63 (290) alignment
Range on Protein: 34-88
Range on HMM: 9-63/290.0
ASNYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSY
|.. | |  . .. | .   .|. .| ..  .|.|. | ||||||| ||...|  
akkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrt

0045823 Metallo-dependent phosphatases 36-402 8.8e-87 284.7 In-house 39-322 (473) alignment
Range on Protein: 36-402
Range on HMM: 39-322/473.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNsehlirregaattsqdiptdpshkeeegscppsqvscpplptlin
. .||. . .  |..|| ...| | .||.||..||||||||||. ||  ..   .                                             
kegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekig.............................................

gyysfdpkplqghnsikKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSYaeginFAEECQSKYGEETYESFMRCFDS
                  |..  ..||||.|||| .| |....|||||..||...|.||||||.| ...        | .|.  ||||. || |.....|
.................fppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglyg.....fgdetlekygedlyeeflewlrs

LPLAAIVeNKfgKWLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRmsdkdyqeFLEIDYLPNPPRGCSCFYGYLAITPFLNN
|||||.. ..  |.|..|||. . ...|  |...||. |.| .|...|| ||||  .|. | .        .| . . .| |||.....|. |.  ||..
lPlaavi.gg..kilfvHGGlspdlplldqireierpleipddgllldllwsdP..weddgdg........llrlrffgnsprgagylFgpdaveeflkk

NDLLGIIRAHQCKEEGIGYAYTNNRkelFPFPLVTTLFSASNYCGSYTNKGAILLIYTDDIKVIKYR
|.|  |.|.|.. .||. . . ...   . .. . |.|||.|||| . |..|.|.|  | |..| ..
ngldlivrGHthvpeGyellfdgkv...igiDtgiTvfSApnYcgrggnlaAvlvidedlisfiqfd

0049330 Metallo-dependent phosphatases 36-398 2.2e-75 246.7 In-house 26-292 (309) alignment
Range on Protein: 36-398
Range on HMM: 26-292/309.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEhlirregaattsqdiptdpshkeeegscppsqvscpplptlin
..|||. . .  |...| ...|.| .||.||..||||||||||. ||  ..   .                                             
klkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfp...........................................

gyysfdpkplqghnsikkPHsPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSYaeginFAEECQSKYGEETYESFMRCFDS
                  |    ..||||.|||| .| |..|.|||||..||...|.||||||.| ....       | .|.. |||.| .| |.....|
..................pe.drlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrllnglyg.....fgdetlrkygaelweefldwlrs

LPLAAIVENkfgKWLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPLLEEVLgrrmsdkdyqefleidYLPNPpRGCSCFYGYLAITPFLNN
|||||....   |.||.|||. . ...|..|..|||. |.|| |..|||.||||| .                   ..||| ||.....|. |.  ||. 
lplaavigg...kilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpireg................fapnp.rglgvvfghtaverflkk

NDLLGIIRAHQCKEEGIGYAYTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDIKV
|.|  |||.|.. ..|. . . ..         . |.|||.|||| . |.||.|.|  |   .
ngldliirghgavfgGyltffdgk.........litvfsapnycgrlgnlgavleidedlvis

0053225 Metallo-dependent phosphatases 36-394 1.1e-69 228.1 In-house 18-280 (293) alignment
Range on Protein: 36-394
Range on HMM: 18-280/293.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEhlirregaattsqdiptdpshkeeegscppsqvscpplptlin
..|||  . .  |..|| ...| | .||.||..|.|||||||.. ||  .. . .                                             
llkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfp...........................................

gyysfdpkplqghnsikkPHsPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSYaeginFAEECQSKY-GEETYESFMRCFD
                  |    ..||||.|||| .| |....|||||. ||.....||||||.. ....       | .|.  || ..| .. ......
..................pe.drlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmllnglyg.....fgdetlrkygaaelwdelldwlr

SLPLAAIVENkfgKWLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsdkdyqeFLEIDYLPNpPRGCSCFYGYLAITPFLN
||||||....   |.|..|||.   . .|..|....|. ..|| |...|| ||||                 .|  ..||. .||.....|. |.  ||.
slplaaligg...kilfvHgGlspdlslldqireinrplriplegllldllwsdp.................dlwsgwlps.yrglgvvfghtavlrflk

NNDLLGIIRAHQCKEEGIGYAYTnnrkelfpfPLVTTLFSASNYCGSYTNKGAILLIYTD
.|.|  |||.||.  .|. . .          . . |.|||.||.| ..|.||.| . ..
kngldliirghqvvpdgylpwfd.........gklvtvfsapnylgrlgnlgavlaldeg

subfamily_PPP2C_pd Subfamily PPP2C 36-87 8.4e-09 28.0 In-house 13-64 (290) alignment
Range on Protein: 36-87
Range on HMM: 13-64/290.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
. | || |.|. |.|.| .... |. .  ...|. |.||.|||| ||...| 
eckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfk

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 37-393 8.2e-56 182.5 In-house 6-303 (317) alignment
Range on Protein: 37-393
Range on HMM: 6-303/317.0
YKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEHLIRRegaattsqdiptdpshkeeegscppS-QVSCPPLPTLIN
 .|.... .  |   | .||  |.  |.| ||. ..||||||| ||. ..      .   .                         . . .   |.   .
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwplssqe.........................eksepkslllessk

GYYSFDPKPLQgHNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYAeginFAEECQSKYGEETYESFMRCFDS
   .  . ..   |  ..     ||||||||||| .| | ...|.|||..|| . |.|||||||| . . .|     | .|.. .| .. ||.|   |  
dvkqtvaavks.vnkevtkgykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvnt.qyG....fyrevkkrysaalyeafqlafnv

LPLAAIVENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsD---KDYQEfleidylpnPPRGCSCFYGYLAITPF
|||.|.|..|    || ||||  .. .|  .. |.|  . |  |  .|| |.||           |   | |.|          .|| .  .|  |.  |
lplcavvnkki...lcmhGGiseelldlkqldklkrpldipdvGvladltwadp...........daevkgyke.........sarGagkvfGakavkef

LNNNDLLGIIRAHQCKEEGigYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLIYT
|.. ||  ..||||  |.|  | . ..||      || |.||| .|||   | .|.| . .
lkkldldlvvrahqvvedG..yeffadrk......lv.tifsapsycGqldniaavlsvdk

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 38-394 4.1e-50 163.8 In-house 6-272 (284) alignment
Range on Protein: 38-394
Range on HMM: 6-272/284.0
KLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEHLIRREGAattsqdiptdpshkeeegscppsqvscpplptlingy
|||..  .  |   | .||  |.  | . ||. ..||||||| ||. ..      .   ..                                       
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeake.....................................

ysfdpkplqghnsikkphsPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKYGEETYESFMRCFDSLP
                     ||||||||||| .| | |..|.|.|. .| . |.|||||||| . .  |     | .||. .| |  ||.|  .| ..|
...................kkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnm.qy....gfyleckkrysealyeafqlafnamp

LAAIVENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKdyqeflEIDYLPNPPRGCSCFYGYLAITPFLNNND
|.|.|..|    .| ||||  .. .|  .. |||  . |  |  .|| |.||           ..      |...  . |||.   .|  |.  ||.. .
lcavvskki...icmhggisedlldlkqldklerpidipdigviadltwadp...........ea......evegykesprgagkvfgakavkeflkkfk

LLGIIRAHQCKEEGigYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLIYTD
|  ..||||   .|  | .  .||      || |.|||  ||| . | .|.| . ..
ldlvvrahqvvmdg..yeffadrk......lv.tifsapsycgqldniaavlnvdee

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 38-87 1.2e-07 24.3 In-house 21-70 (297) alignment
Range on Protein: 38-87
Range on HMM: 21-70/297.0
KLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
|..    |  |.. | ..|| ..... . ||| | ||||||| ||. .| 
kviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfh

subfamily_PPG1_pd Subfamily PPG1 38-87 5e-07 22.2 In-house 12-61 (300) alignment
Range on Protein: 38-87
Range on HMM: 12-61/300.0
KLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
.||  ..|. |..   .|. .|  . .. .|. |.||.|||| |...|| 
ellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifk

subfamily_PPP1C_pd Subfamily PPP1C 39-90 2.2e-11 36.5 In-house 9-60 (282) alignment
Range on Protein: 39-90
Range on HMM: 9-60/282.0
LLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTN
 |... .. |...| ...... .||.|.||. ..||||||. ||. .|....
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsg

subfamily_PPP3C_pd Subfamily PPP3C 40-404 5.9e-139 456.7 In-house 41-322 (452) alignment
Range on Protein: 40-404
Range on HMM: 41-322/452.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSytnsehlirregaattsqdiptdpshkeeegscppsqvscpplptlINGyys
||..... .||||.||.|.|.|||...|||.|||||||||.||...|.                                              ..|   
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfe..............................................vgG...

fdpkplqghnsikKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsyaegINFAEECQSKYGEETYESFMRCFDSLPLA
             .|.|..|||||||||||..|.||.|.|.|||.||||..|.||||||.|..|..     ..|.|||..||.||.|...|..|||||||
.............dPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhltey.....ftfkeeckikyseevydacmesfdslPla

AIVENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPLleevlgrrmsdKDYQEFL-EIDYLPNPPRGCSCFYGYLAITPFLNNNDL
|.....|   ||.|||....||||..|..|.|||||| |||.|||.|||||           .||.|.  | ...||..||||.||.| |...||..|||
allnqqf...lcvhGGlspeikslddikkldrfkeppasGplcdllWsdPl...........edygeekteekfvpnsvrGcsyfysykavceflqkndl

LGIIRAHQCKEEGigyaYTNNRK-ELFPFPLVTTLFSASNYCGSYTNKGAILLIYTDDIKVIKYRSG
|.|||||.....|    |...|| |...||...|||||.||...|.||.|.| ............| 
lsiiraheaqdaG....yrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvmnirqfnss

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 40-93 1.1e-11 37.4 In-house 6-59 (302) alignment
Range on Protein: 40-93
Range on HMM: 6-59/302.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEH
...| .  |||.  .|.| |.|| ..|.|. ..||||||| ||| |. . .|..
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvske

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 40-93 1.2e-11 37.4 In-house 7-60 (302) alignment
Range on Protein: 40-93
Range on HMM: 7-60/302.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEH
...| .  |||.  .|.| |.|| ..|.|. ..||||||| ||| |. . .|..
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvske

PPP_3 40-89 1.8e-10 33.3 In-house 2-51 (271) alignment
Range on Protein: 40-89
Range on HMM: 2-51/271.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
|. .... |.... .... |..|...|||..|.||||||. ||. .|...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfkng

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 41-89 2.3e-06 20.2 In-house 4-52 (284) alignment
Range on Protein: 41-89
Range on HMM: 4-52/284.0
ERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
    |. |. .| ..|. .  |.   .|| . ||||||| ||. .|   
ppedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkn

PP2Ac_SM00156 42-394 7.4e-77 251.0 In-house 3-259 (271) alignment
Range on Protein: 42-394
Range on HMM: 3-259/271.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFsytnsehlirregaattsqdiptdpshkeeegscppsqvscpplptlingyysfd
.. |  |.||. ...| |..|...|||..|.||||||. ||. ..                                                       
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll.......................................................

pkplqghNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqfsyaEGINFAEECQSKYGEETYESFMRCFDSLPLAAI
       .. ..|..  |.||||||||| .| |.||.|.|||..||.....|||||||. ..     .   | ||.. |||.|.|| |...|..|||||.
.......elageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn.....kiygfeeevkrkygkeiyekfeeafsllPlaal

VENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsdkdyqEFLEIDYLPNPpRGCSCFYGYLAITPFLNNNDLLGI
|..|.   || |||. ....|| .|..|.|.||.| .|...||.||||                |  | .. |.  ||.|...|  |.. ||..|.|  |
vdski...lcmhGGlspeleslddirklkrvkekpeegllidllwsdp................eqkekgfqpsk.rglsvvFgedavkeflkknnlkli

IRAHQCKEEGigYAYTNNRkelfpfpLVTTLFSASNYCGSYTNKGAILLIYTD
||||....||  | .  ..        . |.|||.|||....||.|.| ....
iRahevvdeG..yeffadk.......klvtifsapnycdefsnkaavlkvekn

PPP_1 42-89 3e-09 29.5 In-house 3-50 (264) alignment
Range on Protein: 42-89
Range on HMM: 3-50/264.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
..... |.... .|.. ||.||..|..| |.||||||| ||. .| ..
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvg

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 42-87 1.3e-08 27.4 In-house 8-53 (280) alignment
Range on Protein: 42-87
Range on HMM: 8-53/280.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
   ....||.  |... ..|.. . ||. | ||.|||. ||. .|.
eadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfa

subfamily_PPZ_pd Subfamily PPZ 42-87 3.2e-06 19.9 In-house 27-72 (300) alignment
Range on Protein: 42-87
Range on HMM: 27-72/300.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
 | .  .  .| .||  . .|| || .. ..||.|||..||. .|.
nseilqicikarelflaqpallelspsvkivgdvhgqyadllrlft

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 43-89 2.1e-08 26.8 In-house 27-73 (299) alignment
Range on Protein: 43-89
Range on HMM: 27-73/299.0
SSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
  .| | . | . | .. .|| . |||.| ||||||. ||. ||. .
qelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdka

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 44-89 7.3e-08 25.0 In-house 12-57 (281) alignment
Range on Protein: 44-89
Range on HMM: 12-57/281.0
SVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
 .. .| |.  .| .|..|  . .||||.||.|.|| ||  .|   
eienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfell

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 44-87 1.9e-07 23.3 In-house 14-57 (287) alignment
Range on Protein: 44-87
Range on HMM: 14-57/287.0
SVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
 .  ..|.. ....  ..||.. |||...||||||. ||. || 
dilevlekieeileplpalleveapitivGdihGqlddllrifn

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 45-391 1.6e-45 148.7 In-house 16-320 (339) alignment
Range on Protein: 45-391
Range on HMM: 16-320/339.0
VQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSyTNSEHLIRREGAATtsQDIPTdpsHKEEEGSCPPSQvscpPLPTLINGYYSFDPkP
.  |   | .|   |  .|.| |||.|.||||||| ||. ..   |   |  .|  |   .||     .  | |  | |.    |  |  .      | |
laelchrareliwsepiflkleapicvmgdihgqfddllamld.mngwplssqefeal..kditv...rsretgkrpqse....phstqpessndvkp.p

LQGHNSIKKPHS---PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqFSYAeginFAEECQSKYGEETYESFMRCFDSLPLAAI
.   .|..|  .     ||||||||||| .| | ...| |||.||| | ..|||||||| .   ||     |  | . .|  . || |   |. .|..|.
vaapksvnkevttgykrylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvn.tsyg....fyrevnyrydaqlyecfqnmfnvfpfcav

VENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrRMSDKDYQefleidylPNpPRGCSCFYGYLAITPFLNNNDLLGI
..|     .| ||||  .. |.  .  ..|  | |  | . || |.||          ..| |.        |   ||.|  .|  |.  ||.. ||  .
innti...mcmhggisehltsfnqfsvfkrpleipdvgvltdltwadp........dptekgyk........ps.argasfvfgppalraflkkldlqmv

IRAHQCKEEGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
|| ||  |.|  | . . |.       . |.||| ||||   |  |.. |
irghqvvedg..yeffdgrr.......lvtifsapnycgqndntaavfsi

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 45-87 1.3e-07 24.1 In-house 25-67 (307) alignment
Range on Protein: 45-87
Range on HMM: 25-67/307.0
VQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
.. .| ||  .|  | .|. .  | ||.||.|||| ||...| 
fenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfi

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 45-86 9.4e-06 17.8 In-house 21-62 (290) alignment
Range on Protein: 45-86
Range on HMM: 21-62/290.0
VQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIF
.  ..|.. ....   .||.. ||||..||||||. .|.  |
ileilekieeileplpalleveapivivgdihgqldallryf

Metallophos Calcineurin-like phosphoesterase 68-348 2.4e-28 92.8 Pfam-A 2-199 (200) alignment
Range on Protein: 68-348
Range on HMM: 2-199/200.0
PIVVIGDIHGQFCDLVdifsytnsehlirregaattsqdiptdpshkeeegscppsqvscpplptlingyysfDpKPLQGHNSIKKPHSPSYLFLGDYVD
.|.||||.||.. ||                                                          |   |. .. ....    .|||||.||
rilvigDlHgglddle.........................................................d.lllillkiaaeekpdlvlflGDlvd

RGCYSSECILFL--LALKVAYPSRFFMLRGNHESRCMTQFSYAEGINFA-----------------------------EECQSKYGEETYESFMRCFDSL
|| .|||..  |  |.||...| ..|.|||||||.........  . .                                   ..| ...| . ..|. |
rgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflal

PLAAIVENKFgkwLCCHGGIGSKIKSLGSIeslerfkepplsgpfcdliwsdplleevlgrrmsdkdyqefleidylpnpprgCSCFYGYLAITPFLNNN
||.|.|..|.   |..||...|  .|   |                                                     .|. .|. |  ..|...
plralvdgki...lltHgplsssggsgddi.....................................................gselfgpdaleklleky

DLLGIIRAHQCK
..  ..|.|..|
gvdlvlrGHtHk

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 148-392 4.7e-42 136.9 In-house 56-269 (287) alignment
Range on Protein: 148-392
Range on HMM: 56-269/287.0
HNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFg
 |.. ..    |||||||||||  | | .|.|..||.||| .  .|||||| . . .  |     | || . |..|. |. |   |. ||| |.|...  
fnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinkl.y....Gfkeelkrkrqerlykqfndvfselplcarvskri.

kwLCCHGGIGSKIKSLGSIESLERFKEPPLS--GPFCDLIWSDPlleevlgrrmsDKDYQEFlEidylPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAH
  || ||||  |.||| |...|.. . |     |   ||.|.||           .|| . | |    .|  |. |  .|   .  .|.. |.  |.|||
..lcmhGGispklksldslkalkkpttplacdeglqvdllwadp...........ekdaktf.e....lnkiraisvvfGkkevddllkkldidlivrah

QCKEEGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIY
. .|||  ||.  ...       . |.|||. |.|  || ||.. . 
evseeG..yaflfdkr.......lvtvfsapyysgedtnlgavvvvs

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 148-392 3.3e-35 114.5 In-house 62-276 (290) alignment
Range on Protein: 148-392
Range on HMM: 62-276/290.0
HNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFg
 ... .|    .||||||||||  | |  |.|. .|. |. .  .|||||| | . .. |     | ||   | | . .  .   |. |.| | |..|  
fdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrl.y....gfkeelarkrgsrlwkqyqdvfaelslcarvgrki.

kwLCCHGGIGSKIKSLGSIESLERFKEPP--LSGPFCDLIWSDPlleevlgrrMSDKDyqEFLEIdylpNPPRGCSCFYGYLAITPFLNNNDLLGIIRAH
  || ||||  ||.|  |...|.. . |     |   ||.|.||           |||  . ...    |  |. |  .|  ..  .|..  |  |.|||
..lcmhggisqkiesweslkalkkprvpltcdeglqvdllwadp.........trdkd..dtial....nkqraisvvfgkkglddllkklalslivrah

QCKEEGIGYAYtnNRKelfpfplVTTLFSASNYCGSYTNKGAILLIY
. ||||  . .  ..|       . |.|||  |.|  || |||. . 
evkeegfnflf..dkk.......lvtvfsapyysgndtnlgaiatvs

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 150-391 5.9e-39 126.9 In-house 54-261 (280) alignment
Range on Protein: 150-391
Range on HMM: 54-261/280.0
SIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMtqfsyAEGINFAEECQSKYGEETYESFMRCFDSLPLAAIVEnkfGKW
 .  |    ||||||||||| .  | ||.||| || || .|..||||||   .      .   | .|.. .| .. |. |   .|||||.|.|    |. 
rvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi.....nrkygfkdevkrryslalynefqelldslplvalvs...gri

LCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlGRRMSDkdyqefleidyLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKE
|| |||.  |..||  .  | |  ... .    ||.|.||        ...              . .||.|  .|   .  . .  |.  |.| ||  .
lcmhgglsqklvslddlaelrrpfdsedeclamdllwadp......enkvtg...........waensrgvsvifganvvkdltekldidliarghqvvq

EGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
.|  | .  ..|       . |.||| .|.|...|. |.| .
dg..yeffadkk.......lvtvfsapkylgefdnsaavliv

subfamily_PPP1C_pd Subfamily PPP1C 151-393 2e-56 184.3 In-house 59-267 (282) alignment
Range on Protein: 151-393
Range on HMM: 59-267/282.0
IKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwL
   | . .|||||||||||  | | |..|||.|. ||...|.|||||||  .... |     | .||. .|. . ...|. .|. |||||.|..|    |
sgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinri.y....GfydeckrrysiklWktftdvfnclPlaalvdeki...l

CCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEevlgrrmsdKDYQEFLEidylpNPpRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEE
|.|||. ...|||  |....|  | | .|  |||.||||  .         |. ... |     |  || |  .|  ... ||..|||  |.||||. |.
cvhGGlspelksleqirkiqrPlevpekgllcdllWsdp..d.........kevlgwse.....nd.rGvsftfgkdvvekflqkndldlivrahqvved

giGYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLIYT
  || . ..|.      || |.|||.||||.. |.||.| . .
..Gyeffakrq......lv.tvfsapnycgefdnagavlsvde

PPP_3 152-396 3.8e-59 192.9 In-house 52-263 (271) alignment
Range on Protein: 152-396
Range on HMM: 52-263/271.0
KKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQ-SKYGEETYESFMRCFDSLPLAAIVENKFgkwL
..... .||||||||||| .| |..|.|||||. ||.....|||||||| ...  |     | .|.. .|.|...|. ....|. |||||....|.   |
gpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkv.Y....gFkkevlkkkggkkvykklqevFelLplaalidekv...l

CCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIwsdplleevlgrrmsdkDYQEFLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEE
..|||. ..|||| .|..|||..| | .|...||                    ..  . . | | .||.....|  . . ||..|.|  |||||..|||
vvHGGlspsiksldqikklerkievpeegklldll.................lssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkee

giGYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDI
  || .....|       |.|.|||.|||....|.|||| . ... 
..Gyeilhdgk.......vvtvfSapnycerasnagailkleealt

PPP_2 152-348 4.1e-46 150.2 In-house 22-198 (198) alignment
Range on Protein: 152-348
Range on HMM: 22-198/198.0
KKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQ-SKYGEETYESFMRCFDSLPLAAIVENKFgkwL
..... .||||||||||| .| |..|.|||||. ||.....|||||||. ...  |     | .|.. .|.|...|. ....|. |||||....|.   |
lpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkv.y....gFkkevlkkkggkkvykklqevfelLplaalidekv...l

CCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrMSDKDyqefLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCK
..|||. ..||.| .|.. ||..| | .|...||  ..          .||..     . . | |  ||.....|  ... .|..|.|  |||||..|
vvHGGlseeiklldqikkeerkiespeegklldlleeek.........lsdpk....ekeellansarGagllfgpdvteelleknklkliiRaHevk

PPP_1 153-389 8.1e-61 198.6 In-house 52-262 (264) alignment
Range on Protein: 153-389
Range on HMM: 52-262/264.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYAeginFAEECQ-SKYGEETYESFMRCFDSLPLAAIVENKFgkwLC
.... .||||||||||| .| |..|.|||||. ||...|.|||||||| .|.  |.    | .|..  ||..| |. .. .|| |||||....|.   |.
pspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkv.yg....FkkEvlkkkyskeiyktltdvFdvLplaalideki...li

CHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDplleevlgrrMSDKDYQEFLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEG
.|||. .....| .|. ..|..| | .|..||| ..|          ....  ..  . .  .| .||.....|. ... ||..|.|  |||||..||||
vHGGlspeldlldqirkerrktevpeegklcdllekd..........vdillsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeG

igYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAIL
  | ....||       |.|.||||||. . .|.||..
..yeflkkrk.......vvtifsasnyyeegsnrgayv

PPP_4 153-348 1.2e-46 152.3 In-house 25-197 (197) alignment
Range on Protein: 153-348
Range on HMM: 25-197/197.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSyaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCC
.... ||.||||||||| .| |..|.|||||. ||.....|||||||. ....      .| .|...|.|.|... ....|| |||||....|.   |..
pseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnlly.....gfkkevlekhgkeilkklqdvfdllplaalidekv...lvv

HGGIGSKIKSLGSIESLERFKEPP-LSGPFCDL-IWSDPLleevlgrrmsdkDYQEFleidyLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCK
|||. ....|| .|| .||..| |  .. ..|| .||||             . ||      | |  ||.....|. ... ||..|.|  |||.|..|
hgglsdelesldkierierkiespleeekrkdlllwsdpr............eaqeg.....lansvrGagllFgpdvtekfleknnlkliirshelk

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 153-391 9.8e-44 142.6 In-house 75-280 (298) alignment
Range on Protein: 153-391
Range on HMM: 75-280/298.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYG-EETYESFMRCFDSLPLAAIVENKFgkwLC
 |..  ||||||||||| .. | |..||| || ||..||.||||||   . .  |     | |||. .|   . |..|   |..|||.|.. ..    ||
fppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainrv.y....Gfyeeckrrykslrlyaefqdvfnalpltaliggri...lc

CHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKDYqefleIDYLPNpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEG
 |||.  |.||| .. .|.| .... .    ||.|.||           ..        .. .|  || |. .|  ..  .|.. |.  ..||||   .|
mhGGlskklksldqlrelkrpfdskeeslaidllwadp...........enav.....kgwaen.srGvsvvfGedvvkdllekldidlvvrahqvvqdG

igYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLI
  | .  ..|      || |.||| .|||...|  |.. .
..yeffaekk......lv.tifsaphycgqfdnsaavmkv

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 153-392 2.7e-34 111.9 In-house 54-261 (284) alignment
Range on Protein: 153-392
Range on HMM: 54-261/284.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLC
 ||   ||||||||||| .  | ||.|.| || .| .|||||||||   . .  |     | |||| .| .   | ||   |  .||.|.| ..    ||
fphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki.y....gfyeecqrrynkpsvyvsfegvfsvmpltalvgqri...lc

CHGGIGSKIKSLGSIESLER-FKEPPLSGPFCDLIWSDPlleevlgrrmsdKDYQEfleiDYLPNpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEE
 |||.   .. .  . ...| | .|       |..||||             ..|.     . ||  || |  .|  |.  .|.  ..  ..||||  ..
mhggvskmlqnvsqlraikrpfdnpepntlaidilwsdp............tnfqk....gwnpn.srgvsyvfgsdalrklldrlqidlvvrahqvvqd

GigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIY
|  | .  ||.       . |.|||  ||| . |  |.. . 
g..yeffanrr.......lvtifsapfycgqfdnaaavmyvn

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 153-289 2.5e-23 75.7 In-house 71-202 (307) alignment
Range on Protein: 153-289
Range on HMM: 71-202/307.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQ---SKYGEETYESFMRCFDSLPLAAIVENKFgkw
.|    |.| |||||||  | ||||.|.. |..||    .||||||   . .  |     | |||     | ||| .  | |||. ||..|..  |    
rppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk.ky....gfyeecvtsipkcgeeiwalfqrcfnnlpisaliatki...

LCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDP
|| |||.   .  |  .    .    |. |   |..|.||
lcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp

PPP_5_Dcr2 154-348 2e-45 148.2 In-house 25-199 (199) alignment
Range on Protein: 154-348
Range on HMM: 25-199/199.0
PH-SPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRcmtqfSYAEGINFAEECQSK-YGEETYESFMRCFDSLPLAAIVENKFgkwLC
|  . .|.||||||||| .| |..|.|||||. ||.....||||||..     .  |   | .|..|| .|.. |. . ..|| |||||....|.   |.
pseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEde.....qlneiygftkevlskyhgkkiykilsdvfdwlPlaalidekv...lv

CHGGIGSKIKSLGSIESLERFKEPP-LSGPFCDLI-WSDPLleevlgrrmsdkD----YqefleidyLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAH
.|||. ..|||. ..| .||..| |  .|  .||. ||||             |    .          |  ||.....|. ..  ||..|.|  |||.|
vhgglspeiksiellekierkieipeekgekadlllwsdpr............daqegc........klnseRGagllfgpdvtekfleknnlkliirsh

QCK
..|
elk

subfamily_PPZ_pd Subfamily PPZ 154-391 7.3e-38 123.8 In-house 77-280 (300) alignment
Range on Protein: 154-391
Range on HMM: 77-280/300.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVEnkfGKWLCCH
| |  |||||||||||  | | ||.||. |. ||  ||.||||||   .|.  |     | .||. .   . ...|.  |..|||||||    || .| |
ppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrv.y....gfydeckrrcnikiwktfvdtfntlplaaiva...gkifcvh

GGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrRMSDKDYQEFlEidylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGig
||.   ..|.  |  . |  . |  |   ||.||||          | .....  |        || |  |  .||  |||.  .  . |||   |.|  
gglspvlnsmdeirhvvrptdvpdfglindllwsdp........tdssnewedn.e........rgvsycynkvainkflnkfgfdlvcrahmvvedg..

YAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLI
| . |.|       || |.||| |||| . | ||.. .
yeffndrs......lv.tvfsapnycgefdnwgavmsv

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 154-391 1.9e-35 115.5 In-house 60-263 (281) alignment
Range on Protein: 154-391
Range on HMM: 60-263/281.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCH
.    ..|||||||||  | |....|..||..|. | ..||||||   . .  |     | .||. ||||| .  | |||. ||..| ....    || |
vpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnki.y....gfyvecvtkyGeelwalfqrcfnrlpisaliakrv...lcmh

GGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKDYQEFLE-IdylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGi
||.  .. .|  .    .  ...  |   ||.|.||           |.. .|. . .       || |  .|   .     . ..  ||||||   .| 
GGlsPeltaldelrnrpkpirnldrGlviDllwadp...........dnkveewkass.......rGssftfGknvvddvckrleveliirahqvvqdG.

gYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
 |   . ||       . |.||. |||  |.| .|.| .
.yevlsgrk.......litvfsvpnycafyknaaavlkv

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 154-391 4.1e-33 107.9 In-house 76-280 (299) alignment
Range on Protein: 154-391
Range on HMM: 76-280/299.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGE-ETYESFMRCFDSLPLAAIVEnkfGKWLCC
|    .||||||||||    | | .||. |. || ||||||||||  .. .  |     | |||. .|     .  |  .|. .||. ..    .. || 
ppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrv.y....gfyeecnkrykstrlwsifqdafaampltglig...srilcm

HGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKDYqefleIDYLPNpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGi
|||.  |...|  .  | | ..||      ||.|.||           |.       .|.|.|  || |  .|   ..  ... |.  . ||||  ..| 
hgglspklqtldqlrdltrpqdppnpslgidllwadp...........dqsv.....kdwlan.vrgvsyvfgqdvvadvisrldidlvarahqvvqdg.

gYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
 | .  ..|       . |.|||  ||| . |  ||. .
.yeffaskk.......lvtifsaphycgqfdnsaaimkv

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 154-389 3.2e-31 101.7 In-house 75-279 (297) alignment
Range on Protein: 154-389
Range on HMM: 75-279/297.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKYGE-ETYESFMRCFDSLPLAAIVENKFgkwLCC
| .  ||||||||||| .| | |..||| || .|. .|.||||||   . .  |     | |||| .|     | .|   |. |||. .. .|    || 
pptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnk.vy....gfyeecqkryqsvrmyaafqdvfnwlpltgliatki...lcm

HGGIGS---KIKSLGSIESLERFKEPpLSGPFCDLIWSDPLleevlgrrmSDkdYQEFLEIDylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKE
|||.     |  .| ..  .|| .|    .  .||.|.||.         |      |.| .      ||. | .|  |.     . .|  . ||||  .
hgglsplltkeftldtlrkiersteg.kerlvadllwadpi.........sg..lsgfmenq......rgagcgfgrdavlklcsefkldlvcrahqvvq

EGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAIL
.|  | .   ||       . |.|||  ||| . |  |..
dg..yeffagrk.......lvtifsaphycgqfdncaafm

subfamily_PPP6C_pd Subfamily PPP6C 156-398 8.9e-47 152.6 In-house 70-277 (290) alignment
Range on Protein: 156-398
Range on HMM: 70-277/290.0
SpSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLCCHG
. ||.||||.|||| || | .  ||.||. ||.|  .|||||||| .||  |     | .||..|||.  ..  ... || |..|||....    || ||
t.syvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqv.y....gfydeclnkygnanawkyctkvfdlltiaaiideqv...lcvhG

GIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRMSdkdyqefleidylpnpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGY
|. ...| | .|. .|| .| |  |.||||.||||  |.|    .|                |||   ..|    . |...|.|  |.||||  |||. |
glspdvktldqirvieraqeiphkgafcdlvwsdp..edvetwavs................prgagylfgskvtkefvhinnlklicrahqlveeglky

AYTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDIKV
 . ..         . |..|| |||    |  .|| . ... . 
mfdek.........lvtvwsapnycyrcgnvasilaledaeere

subfamily_PPP7C_pd Subfamily PPP7C 156-401 1.4e-29 96.0 In-house 92-332 (383) alignment
Range on Protein: 156-401
Range on HMM: 92-332/383.0
SPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMtQFSYAeginFAEECQSKY---GEETYESFMRCFDSLPLAAIVENKFgkwLCC
. .|.| ||.||||  | | .| |||| ..||  ... |||||   .    |     |  | .|||   |..  . .   |  ||||.....|    | .
enpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhil.nlryG....fikeveskykvhgkkilrlledvfawlplatlideki...liv

HGGIgSKIKSLGSIESLERFKEPPL-SGPFCDLIwSDPLLEEVLGRRMSDKDYQEFLEIDY---------LPNPPRGCSCFYGYLAITPFLNNNDLLGII
|||| |.. .|  ....|| |   .   |  .   .    .|    ... ..... |.| .          ||  ||  ...|    . .|.. .|  .|
hGGi.sdktdlelldkiersklvsvlrpplkege.eaekekeessvkvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlklli

RAHQCKEEGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDD-IKVIKY
|.|.|| ||  | .. ..|       | |.||||||    .|.|| . . .|   ....|
rsheckpeG..yefvhdkk.......vltifsasnyyeeGsnrGayvklgkdltprivqy

subfamily_PPP5C_pd Subfamily PPP5C 157-398 1.7e-47 155.0 In-house 94-301 (322) alignment
Range on Protein: 157-398
Range on HMM: 94-301/322.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGI
 .||| ||.|||| .| |.|| ||..|. || .||. ||||||  | .. |     | .|...|| |. .. | . |..|||| ....|.   | .|||.
npylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkl.y....GfegevkakytekvadlftevfnwlPlahvinekv...lvvhGGl

GSKI-KSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRMSDkdyqefleidylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGigYA
 |.   .|  .  ..|...|| .| ...|.||||  .|  || .|                 || .. .|    . ||..|.|  |||.|. ||||  | 
fsedgvtlddlrkidrnaqppeegllvellwsdp..qeanGrspsk................rGvgvqfGpdvtkkflkennleliirshevkeeG..ye

YTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDIKV
 ... |       . |.||| ||| . .||||.. . .|| |.
vehdGk.......litvfsapnycdqmgnkgafitlrgddlkl

subfamily_PPP2C_pd Subfamily PPP2C 157-391 9.4e-47 152.6 In-house 72-272 (290) alignment
Range on Protein: 157-391
Range on HMM: 72-272/290.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLCCHGG
  ||||||||||| || |.. .| |||| |..|  .|||||||| .||  |     | .||  |||.   .. |   || |||.|.|...    .| |||
tnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqv.y....gfydeclrkygnanvwkyftdlfdylpltalvdeqi...fclhgg

IGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDkDYQEFLEIdylpnpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGYA
.  .|..|  |..|.|..| |  ||.|||.||||           | | . .         |||.   .|      | ..|.|  |.||||   ||  ..
lspsidtldkiraldrlqevphegplcdllwsdp...........d.drggwgis......prgagytfgkdisekfnktngltliarahqlvmegynws

YTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLI
. .|         |.|.||| |||    |..||| .
hdrn.........vvtifsapnycyrcgnqaailel

subfamily_PPP4C_pd Subfamily PPP4C 157-391 1.9e-46 151.6 In-house 71-271 (288) alignment
Range on Protein: 157-391
Range on HMM: 71-271/288.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLCCHGG
 .||||||.|||| || |..|.|||||| || |  ..||||||| .|| .|     | .|| .|||.   ..  .. || |.||||...|    .| |||
tnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitq.vy....gfydeclrkygsanvwryctevfdylslaaiidgki...fcvhgg

IGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRMSdkdyqefleidylpnpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGYA
.  .|..|  | |..| .| | .||.|||.||||  |.. |  .|                |||   ..|  ... | ..||.  |.||||   ||  . 
lspsistldeirsidrkqevphegplcdllwsdp..edaegwavs................prgagylfgsdvveqfneandielicrahqlvmegyklh

YTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLI
....         | |..|| |||    |. ||| .
fnek.........vltvwsapnycyrcgnvaailel

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 157-391 1e-28 93.7 In-house 35-242 (263) alignment
Range on Protein: 157-391
Range on HMM: 35-242/263.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYAEGINFAEECQSK-YGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGG
  ||||||||||| .| | |..|..||.| | ....|||||| ... .  |    .. .  | .   |  |. | . |  .||.||| ..    || |||
tqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkaink.nygfhaelkkrfqreevyesvynhfnqvfsymplcaivskri...lcmhgg

IGSKIKSLGSIESLERFKEPPLSGPF-CDLIWSDPlleevlgrrmsDKDYQEFLeidylPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEegIGY
|  ..|||  | ..    |   . |. |||.|.||           .|| . |      ||  |  |  .|   .  . .  |.  |.||||  |   ||
isphlkslddiraiplpletakthplacdllwadp...........ekdakgfe.....pnkiraisnvfgkkevddlckrldidlivrahqvve..ygy

AYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
|.  .|.       . |.|||| |     |  |....
affadrr.......litvfsasryqielcnyaavvvv

subfamily_PPPLV_pd Subfamily PPPLV 158-400 2.3e-47 154.7 In-house 57-284 (290) alignment
Range on Protein: 158-400
Range on HMM: 57-284/290.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRcmtqfSYAEGINFAEECQSKYG---EETYESFMRCFDSLPLAAIVENKFgkwLCCHG
|.|||||||||| .| | | .|||||| |||....|||||| .     | .| |..  |.. |.|   ||..|.|. .|| |||||....|    .|.|.
sllflgdyvdrgdfsveliayllalkvlypskvlllrgnhele.....svqesieykgegsfkfgdsleevweafnnvfdalplaavidrkv...fcvha

GIGSKIKSLGSIES----LERFKEPPLSGPF-CDLIWSDPlleeVLGRRMSDKDyQEFLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKE
||   |.. . | .    |||.|..    |.  |..||||      .|  | .  .  |.  ...|  || .. ..  |.  ||..|.|  ..|||. ||
gipraimtqayisaiqdilerlkddidgaplaldilwsdp....aedrdlslrg.elvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevke

EGIGYAyTNNRkelfpfplVTTLFSASNYCGSyTNKGAILLIYTDDIKVIK
.|| .  .. |        . |.||.|.|||| .|. |..|.  . ...|.
kGirlq.qkgr........lltvfsssrycGs.sneaalilvdkkklriit

subfamily_PPG1_pd Subfamily PPG1 158-395 4.6e-47 153.7 In-house 70-286 (300) alignment
Range on Protein: 158-395
Range on HMM: 70-286/300.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKY-GE-ETYESFMRCFDSLPLAAIVENKFgkwLCCHGG
 ||||||||||| || | | .|..||. ||||  .|||||||| .|| .|     |  ||  || |.   .. .   || | ||||....     | |||
nylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitq.vy....gfyteclrkyggnsrvwkylteifdylvlaaiideei...ycvhgg

IGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPLLEEVLGRRMSDKDYQEFLEidylpnPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGYA
.  ...|.  |  |.||.| |  | ..||.||||  ..       |.. |.| .       .||.   ||   .  ||.|||.  ||||||   ||    
lspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvv......sqrgagysygkdvvekflrnndmnriirahqlcnegyqil

YTNnrkelfpfpLVTTLFSASNYCGSYTNKGAILLIYTDD
. |         ...|..|| |||    || .|| .|  |
fdn.........klstvwsapnycyrcgnkasilelyekd

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 158-395 3e-37 121.4 In-house 73-290 (302) alignment
Range on Protein: 158-395
Range on HMM: 73-290/302.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqFSYAEGINFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGIG
 ..|||||||||  | ||| ...|||| ||... .||||||....  |.|.   .. .    | | | .| |  .|  .||||.| .|    || |||| 
kfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkain.faygfreelenrlgkkdgkeiwekfnevfsfmplaalvgeki...lcvhggis

SKIKSLGSIESLERFKEPPLSGPF-CDLIWSDPLLEEVLGRRMSDKdyqefleiDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEgiGYAY
 |..|| .|....|  .     ..  ||...|||  ..|    .          .|  |  || |  .   |.. . .. .|  |.||||   |  |. .
pklesledikkikrplkevtedslaqdllfadpldvqllaavsekP........kyaknivrglsvvfneaavrdvckrlnlklivrahqmiPe..Gfkf

TNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDD
  ..|       . |.|||..|     ||||.| . |. 
fadkk.......lltifsaprymnesdnkGavlkvdtng

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 158-395 4.1e-37 121.0 In-house 74-291 (302) alignment
Range on Protein: 158-395
Range on HMM: 74-291/302.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqFSYAEGINFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGIG
 ..|||||||||  | ||| ...|||| ||... .||||||....  |.|.   .. .    | | | .| |  .|  .||||.| .|    || |||| 
kfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkain.faygfreelenrlgkkdgkeiwekfnevfsfmplaalvgeki...lcvhggis

SKIKSLGSIESLERFKEPPLSGPF-CDLIWSDPLLEEVLGRRMSDKdyqefleiDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEgiGYAY
 |..|| .|....|  .   . ..  ||...|||  ..|    .          .|  |  || |  .   |.. . .. .|  |.||||   |  |. .
pklesledikkikrplkevtedslaqdllfadpldvqllaavsekP........kyaknivrglsvvfneaavrdvckrlnlklivrahqmiPe..Gfkf

TNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDD
  ..|       . |.|||..|     ||||.| . |. 
fadkk.......lltifsaprymnesdnkGavlkvdtng

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 159-391 8.5e-28 90.6 In-house 63-261 (280) alignment
Range on Protein: 159-391
Range on HMM: 63-261/280.0
YLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGIGS
 .|||||||||    | ...|..||. |  | ..||||||. .. .  |     |  ||| |||   .  |  ||. .|..... ..    || |||.  
lmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki.y....gfyvecqykygvglwwdfqscfnrmpmsgliskrv...lcmhgglsp

KIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmSDKDYQEFLEIdylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGigYAYTN
..  | .|  . |  ||   | . ||.||||          ..|    |  |       || | ..|   .    .. ..  ||||||  ..|  |    
elinldtirniprpcepldrgllidllwsdp..........tnkgegwfhsi.......rgisymfgkgvveqacksleidliirahqvvqdg..yemma

NRKelfpfplVTTLFSASNYCGSYTNKGAILLI
 |.       . |.||  |||  .||  |.. .
grr.......litvfsvpnycaqftnaaavvcl

EF-hand_7 EF-hand domain pair 609-652 8.5e-08 22.2 Pfam-A 22-65 (66) alignment
Range on Protein: 609-652
Range on HMM: 22-65/66.0
LRKHFSQTLLDKVGKQDETQIKLIFQSIDKNNDGQLSMTELQDF
|.... ... ..  .. ....  ||. ||||.||.||..|.  .
LlrllkhlgsplideevrevldyifkeiDkngdGvlsfeEflqa

EF-hand_1 EF hand 629-652 5.1e-07 18.6 Pfam-A 2-25 (29) alignment
Range on Protein: 629-652
Range on HMM: 2-25/29.0
IKLIFQSIDKNNDGQLSMTELQDF
.| .|. .||..||..|  |....
lkeaFkefDkDgdGkIsfeEfkea

EF-hand_6 EF-hand domain 630-653 1.4e-06 17.7 Pfam-A 3-26 (31) alignment
Range on Protein: 630-653
Range on HMM: 3-26/31.0
KLIFQSIDKNNDGQLSMTELQDFA
. .|. .||..||...  ||... 
reaFklfDkdgdGkidaeELrkaL

EF-hand_5 EF hand 632-652 3.7e-08 21.8 Pfam-A 4-24 (25) alignment
Range on Protein: 632-652
Range on HMM: 4-24/25.0
IFQSIDKNNDGQLSMTELQDF
.|. .|||.||..|. ||. .
tFrafDkNgDGkIsreELkrl