Gene PPP6C-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP6C
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP184_AA protein Get Run
AqueP184_AA_1-311 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP2C_pd Subfamily PPP2C 2-221 2.4e-109 358.0 In-house 2-221 (290) alignment
Range on Protein: 2-221
Range on HMM: 2-221/290.0
SELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKY
..||..||  |.|. |.|.|.|.||. . ..| .|||||.| .|||||||.||||.|| |||. ||. ||| |.|.||.|||||||.|| | | .|| .|
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PNKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDIS
...||.||||||||||||||||||||. |||||| |.|  ..|| |...|..|.|..|.||||||...|||.||..||  |.||||..|||.||||.| .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWAVSPRGAGYLFGNSVTQE
||..||||||| ||. ....
gwgisprgagytfgkdisek

0049330 Metallo-dependent phosphatases 2-294 1.8e-101 332.3 In-house 15-288 (309) alignment
Range on Protein: 2-294
Range on HMM: 15-288/309.0
SELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKY
| ||..||| .|...|.|.||..|.......|..|.|....  ...|.||||||..||..|..  | .|.. .||.||.||||..|||....|| || .|
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PNKITLLRGNHESRQITQVYGFYDECMNKYGnANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPE-DI
|....|||||||.|.....|||.||.. ||| |. |........ | .||.|....|||||||||....||||| ..| .|||..| .|||.||||  ..
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

SGWAVSPRGAGYLFGNSVTQegtcyvihcalvplvtitvSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDA
.|.| .|||.|..||  ...                   .|...|.|.||.|.|..|..|....||..|.||.||||||.|.|| ...|.|.. 
egfapnprglgvvfghtave...................rflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleided

subfamily_PPP6C_pd Subfamily PPP6C 3-312 2.5e-181 594.2 In-house 1-289 (290) alignment
Range on Protein: 3-312
Range on HMM: 1-289/290.0
ELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYP
|||.||||||||.||.||.||||||.|.||||||||||||..||||||||||||||||||||||||.|||||||.|||||||||||||||||||||||||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

NKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDISG
..|||||||||||||||||||||||.|||||||||.||.|||||||||||||.|||||||||||.||||||||.|.| .||||.|||||||||||||.. 
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDANleGKEAK
|||||||||||||..||.|                   |.|.|||||||||||||.||.|||||..||||||||||||||||.||||...||.   .|||
wavsprgagylfgskvtke...................fvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae..ereak

LFQAVPDNER
||.||||.||
lfkavpdeer

subfamily_PPP4C_pd Subfamily PPP4C 3-308 1.8e-139 456.9 In-house 2-286 (288) alignment
Range on Protein: 3-308
Range on HMM: 2-286/288.0
ELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYP
.||. ||  ..|. ..|.|.|.||  . ..|.|||||| | .||||||||||||||| |||. ||..|.|.|.|.|||||||.||.|||  ||.||..||
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

NKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDISG
..|||.|||||||||||||||||||..|||.|| ||||..|||.|..|||||....||||||||...|||.||.||| .|.||||..|||.||||||..|
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIkDANLEgKEAK
|||||||||||||..|...                   |.. |...||||||||| || |..|.....||||||||||||||.|.|| . |..|. |. |
wavsprgagylfgsdvveq...................fneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaailel.deeld.kdfk

LFQAVP
.|.|..
ifeaaa

0045823 Metallo-dependent phosphatases 3-311 3.2e-110 361.9 In-house 29-328 (473) alignment
Range on Protein: 3-311
Range on HMM: 29-328/473.0
ELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYP
 ||..||  ||...|.|..|.||.|.....| .|.|....  ...|.||||||..||..|..  | .|.. .||.||.||||..|||.. .|| || |||
dldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikyp

NKITLLRGNHESRQITQVYGFYDECMNKYgNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDISG
....|||||||.|.....|||.||.. || ... ......... | .||.|....|.|||||||....|||||.|.| .|||..|...||.||||....|
gnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddg

--------WAVSPRGAGYLFGNSVtqegtcyvihcalvplvtiTVSFMHLNNLKLICRAHQLVHEGIKYMFDQR------LVTVWSAPNYCYRCGNIASI
        .  ||||||||||  .                   .  |.. |.|.||.|.|. | ||....|| .      ..||.||||||.|.|| |..
dgllrlrffgnsprgagylFgpda...................veeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAv

LIIKDaNLegKEAKLFQAVPDNE
|.| . .|   . ..|...|.  
lvide.dl..isfiqfdpsphpl

0053225 Metallo-dependent phosphatases 3-294 4.1e-99 324.6 In-house 8-280 (293) alignment
Range on Protein: 3-294
Range on HMM: 8-280/293.0
ELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYP
 || .||| .....|.|.||..|.......|..|.|....  ...|.|||||...||..|..  | .|.. .||.||.||||..|||....|| ||..||
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp

NKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDISG
....|||||||.......|||.||.. |||.|. |........ | .||.|....|.|||||||.. .||||| |.| ..||.||...||.|||| ..||
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsg

WAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDA
|. |.||.|..||  ....                   |...|.|.||.|.||.|..|....||..||||.|||||..|.|| ...|.... 
wlpsyrglgvvfghtavlr...................flkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeg

subfamily_PPG1_pd Subfamily PPG1 4-220 2.8e-95 312.1 In-house 1-230 (300) alignment
Range on Protein: 4-220
Range on HMM: 1-230/300.0
LDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPN
||| .|  .|.. | |  .|.|.| . .||..||||. . .|||| ||.||||||. |.|. |||.||| |.|.||.||||.||.|| . |..|| .|| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

KITLLRGNHESRQITQVYGFYDECMNKY-GNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPE----
.|||||||||||||||||||| ||..|| ||.. |.|  ..|| |..|||||... ||||||||.|...|||. .||  |.|.|||..||.|||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DISG--WAVSPRGAGYLFGNSVTQ
      | .|  . ||.||||| .|..|..
ptldhpdregqhfvvsqrgagysygkdvve

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 11-293 6e-78 254.9 In-house 18-282 (298) alignment
Range on Protein: 11-293
Range on HMM: 18-282/298.0
AKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRG
.| .. ..|....||.. . ... . . .  | .|..||||||||. ||  ||  .|  ||. |.|.||.|||| ..||. . ||. |.||||.. ||||
kkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrG

NHESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPED-ISGWAVSPRG
|||  .| .|||||.|| ..| . . .    .||. | ..|.| ...||.|||||...|.|||.|.. | .. ..|    ||.|.|||. ..||| . ||
nheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrG

AGYLFGNSVTQEgtcyvihcalvplvtiTVSFMhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
... ||. | ..                 .. .   .. |..||||.| .| ... ...|||..|||.|| .  | |.......
vsvvfGedvvkd................llekl...didlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvde

subfamily_PPP1C_pd Subfamily PPP1C 13-220 3.9e-76 248.9 In-house 6-213 (282) alignment
Range on Protein: 13-220
Range on HMM: 6-213/282.0
KCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNH
|   |.|.|...|...  ..||... .  .  ||...||||||..||  || |.|  |...|.|.||.||||  |||| . ||..| |||... ||||||
kevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnh

ESRQITQVYGFYDECMNKYGNAnAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPE-DISGWAVSPRGAG
|| .|...||||||| ..|..   |.   .||. | .||..|...||||||||||.| |.|||.| | .|.|..|  |||.||||. .. ||. . ||  
esasinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvs

YLFGNSVTQ
. ||..| .
ftfgkdvve

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 13-293 3.2e-68 223.3 In-house 3-271 (284) alignment
Range on Protein: 13-293
Range on HMM: 3-271/284.0
KCQY-LTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQI------PDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKI
.||  |.|.|| .||    .|. .|.  . . .||...||||||| ||  |.   |         .. |.|.||.|||| .|.|  | |...| ..|.|.
ncqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkv

TLLRGNHESRQITQVYGFYDECMNKYGNAnAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPE-DISGWA
.||||||||| . . |||| || ..| .|  .      |  . ..|.......|.|||.| ..  |.|.  ..| |.||  |  .||.|.||| ...|..
fllrgnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyk

VSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
 |||||| .||..  .|                   |..  .|.|. ||||.| .| ... |..|||..||| || .  |||..| ...
esprgagkvfgakavke...................flkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvde

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 13-290 6.9e-63 205.7 In-house 19-280 (297) alignment
Range on Protein: 13-290
Range on HMM: 19-280/297.0
KCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNH
 .. .||. . || |   |..  . ..  | .|. ||||||||| ||  ||. ||  | . |.|.||.|||| .|.||   ||. | |.| .. ||||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSP---EVKTLDQIRTIDRGIEiPHEGAFCDLVWSDP-EDISGWAVSPR
|   . .|||||.|| ..|     .     ||. | .. .| ...||.||||||   .  ||| .| |.|  |  .|.  .||.|.||   .||.    |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfmenqr

GAGYLFGNSVtqegtcyVihcalvplVTITVSFmhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILI
|||  ||          |        . .   |    .| |.|||||.|..| ...  ..|||..||| || .  | |... 
gagcgfgrda.......v........lklcsef....kldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafms

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 13-293 3.1e-52 170.7 In-house 17-280 (307) alignment
Range on Protein: 13-293
Range on HMM: 17-280/307.0
KCQYlTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNH
| || | .|....      ..  |  .  .  |. | ||.|||| || ..|   |. |.| ||| ||.||||  |||.   |.| |  ||..| ||||||
kiqy.tkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnh

ESRQITQVYGFYDECMNKYGN--ANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPED-ISGWAVSPRG
|  .. . ||||.||.    .   . |    ..|. | |.|.|  ..||.|||||| .  ||..|   . |  |  |   |..|.||.  .  |  | ||
eiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrg

AGYLFGNSVTQEgTCYVIhcalvplvtitvsfmhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
.|. ||  | ..  |  .                   ..|| ||||.. .|   .  ..|.|..||| ||    |   .| . .
sgftfgtnvidd.vckrl..................gveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvde

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 13-67 1.2e-09 30.7 In-house 4-59 (317) alignment
Range on Protein: 13-67
Range on HMM: 4-59/317.0
KCQ-YLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGG
|||  ..|.|| .||    .|. .|     . .|||..||||||| ||  |.   |
kcqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG

subfamily_PPZ_pd Subfamily PPZ 14-294 2.5e-62 204.1 In-house 22-283 (300) alignment
Range on Protein: 14-294
Range on HMM: 22-283/300.0
CQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHE
   | ..|. ..|    .|.| . ..  .  .| . ||.|||. ||  ||   |  | . |.|.||.||||  ||||   ||  | |||... |||||||
nvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhe

SRQITQVYGFYDECMNKyGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDIS-GWAVSPRGAGY
  ..|.||||||||  .  | . |.     |. | .|||.  ...|||||||| ....|.|| . |  ..|  |   ||.|||| | |  |    ||  |
canvtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsy

lfgnsvtqegtCYVIhcalvplVTITvSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDA
           ||         |.|   |.    . |.|||| .| .| ... |. ||||.||||||    |  ... . . 
...........cynk.......vain.kflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvseg

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 14-297 2.9e-62 203.6 In-house 3-266 (280) alignment
Range on Protein: 14-297
Range on HMM: 3-266/280.0
CQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHE
|. .|  |.  .   |  ...||||.    .|. | |||| |. |.. ||   |..|.   .|.||.||||   .| .  |. || .| ..| |||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECMNKYGNANAWRYCcKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPED-ISGWAVSPRGAGY
.  . ..|||| ||  ||| .  | .   .|. . ....| ..|||.|||||||.  || || | | .|    | . ||.|||| .   ||  | ||  |
tpsvnkiygfyvecqykygvglwwdfq.scfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGNSVTQEgTCYVIhcalvplvtitvsfmhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIkDANLE
.||. | .. .|  .                  .. || ||||.|..| . |  .||.||.| |||| .  | |..... .|||.
mfgkgvveq.acksl..................eidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvcl.nanlq

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 15-291 1e-53 175.5 In-house 4-286 (302) alignment
Range on Protein: 15-291
Range on HMM: 4-286/302.0
QYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQ-----------IPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPN
. ....|| .|.. | .|| .|...  . .|||. ||||||| ||  .. .  .                .||.||.||||. |.|  . ...||  ||.
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

KITLLRGNHESRQITQVYGFYDECMNKYGNAN---AWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGI-EIPHEGAFCDLVWSDPED
.  |||||||.. |   ||| .|  |..|...    |.   .||  . .||.. ...||||||.|| ...|..|. |.| . |. ..    ||...|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

ISGWAVSPRGAGYLFgNSVTQEGTCYviHCALVplvtitVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILII
. . |. ..   | . | | .   ..    | |        . .  ||||| |||| . || |.. |..|.|..|||.|     |  ..| .
vqllaavsekPkyak.nivrglsvvf..neaav......rdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 15-291 1.2e-53 175.3 In-house 5-287 (302) alignment
Range on Protein: 15-291
Range on HMM: 5-287/302.0
QYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQ-----------IPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPN
. ....|| .|.. | .|| .|...  . .|||. ||||||| ||  .. .  .                .||.||.||||. |.|  . ...||  ||.
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

KITLLRGNHESRQITQVYGFYDECMNKYGNAN---AWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGI-EIPHEGAFCDLVWSDPED
.  |||||||.. |   ||| .|  |..|...    |.   .||  . .||.. ...||||||.|| ...|..|. |.| . |. ..    ||...|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

ISGWAVSPRGAGYLFgNSVTQEGTCYviHCALVplvtitVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILII
. . |. ..   | . | | .   ..    | |        . .  ||||| |||| . || |.. |..|.|..|||.|     |  ..| .
vqllaavsekPkyak.nivrglsvvf..neaav......rdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv

subfamily_PPP3C_pd Subfamily PPP3C 16-297 1.3e-77 254.5 In-house 40-315 (452) alignment
Range on Protein: 16-297
Range on HMM: 40-315/452.0
YLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESR
 |.|..  |. . ...|| .|...  | .|.||.|||||||||| .||  ||.  .|.|.|.||.|||||.|.|.   |..|| .||... |||||||.|
rleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecr

QITQVYGFYDECMNKYGNaNAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEdisgwavsprgagYLFG
 .|. . | .||  ||.. . .  |.. || | .||....| ||||||||||.|.||.|...||  |.|. |..|||.||||                .|
hlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPl.............edyg

NSVTQEG--TCYVIHCALVPLVTITVSFMHLNNLKLICRAHQLVHEGIKYMFD------QRLVTVWSAPNYCYRCGNIASILIIKDANLE
.. |.|      |  |. .   . ...|.. |.|  | |||.  ..| .   .        |.|..|||||.    | |..| ... ...
eekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvmn

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 16-293 2.7e-67 220.1 In-house 23-282 (299) alignment
Range on Protein: 16-293
Range on HMM: 23-282/299.0
YLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESR
 . |.||..||.   . ..... .  | .|. ||||||||. ||  .|   |  ||. ..|.||.||||   ||. | ||  | |||... .||||||  
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecp

QITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPED-ISGWAVSPRGAGYLF
 | .|||||.|| ..|  .  |    . |. . .. .| ...||.||||||...||||.| . |  . |      ||.|.||.. . .|    ||  |.|
ainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvf

GNSVTQEgtcyvihcalvplV--TItvsfmhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
|. | ..             |  ..        .. |..||||.| .| ... ...|||..||| || .  | |.|. . .
gqdvvad.............visrl........didlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvde

PPP_3 17-221 7.5e-89 290.3 In-house 2-207 (271) alignment
Range on Protein: 17-221
Range on HMM: 2-207/271.0
LTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQ
|.|||||.|.. . ..| .|||.. . .|||||||||||..|| |||..||..|.|.|.|.||.||||..|||... ||.|| |||....||||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDL-VWSDPEDISGWAVSPRGAGYLFG
|..||||..|...|.|... ......||.||..||.||..||.|||||||..|.||||....| ||.|.||...|| ..||||. .|.. |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

NSVTQE
..||.|
pdvtee

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 17-297 7.2e-70 228.4 In-house 8-268 (281) alignment
Range on Protein: 17-297
Range on HMM: 8-268/281.0
LTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQ
.|..|....   |  .. ||...  . .|..| ||.|.|| ||..||   |..|.. .||.||.||||  |||..  |.||| .|...| |||||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

ITQVYGFYDECMNKYGNaNAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPED-ISGWAVSPRGAGYLFG
. ..|||| ||. |||  . |    . |. | |.| |...|||.|||||||. .||..| . . |. .. |   ||.|.||..   .|  | ||....||
vnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

NSVTQEgTCYVIhcalvplvtitvsfmhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIkDANLE
..| .. .|  .                  .. || ||||.|..|.. .  ..|.||.|.||||    | |..| . |..|.
knvvdd.vckrl..................eveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkv.detlg

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 17-293 1.1e-68 224.4 In-house 6-263 (280) alignment
Range on Protein: 17-293
Range on HMM: 6-263/280.0
LTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQ
. | ..... . . ..|. .. .  | .||.||||.|||. ||  ||   .  ||. |.|.||.|||| . ||    ||. |..|||.. .||||||  .
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

ITQVYGFYDECMNKYGNAnAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPE-DISGWAVSPRGAGYLFG
| . |||.||....| .|  .    ...| | ..|..  ..||.|||||.....||... . | .. ..|    ||.|.||| ...||| ..||. ..||
inrkygfkdevkrrysla.lynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifg

NSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
. | ..                   .... .. ||.| ||.| .| ... |..||||.|||.|.    | |..||...
anvvkd...................ltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivde

PPP_1 18-221 2.8e-86 282.0 In-house 2-213 (264) alignment
Range on Protein: 18-221
Range on HMM: 2-213/264.0
TENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQI
.|.||..|.. . .|| .|.|.. | ...||||||||||.|| .||..||. |.|.|.|.||.||||..|.|... ||.|| |||....||||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDL--------VWSDPEDISGWAVSPRG
|.||||..|...|..... ......|||.|..||.||...|.||||||||...|||||...| .|.|.||..|||        ...|.|. ...| |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYLFGNSVTQE
||||||..||..
agylfgkdvtek

PP2Ac_SM00156 18-221 5.7e-79 257.9 In-house 2-205 (271) alignment
Range on Protein: 18-221
Range on HMM: 2-205/271.0
TENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQI
...|...|.. |...| .|.|.  |..||||.||||||..|| .|....|. |.. |||.||.||||..|.|. . |..|| .||.|..||||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECMNKYgNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDP-EDISGWAVSPRGAGYLFGN
...|||..|...|| .....  . ..|.||..||..|...||.|||||||...||.|| ..|  |.|.|| ..||.|||| .. .|.. | ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

SVTQE
....|
davke

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 21-292 2.5e-55 180.9 In-house 7-261 (284) alignment
Range on Protein: 21-292
Range on HMM: 7-261/284.0
ELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQV
... |  ...... ..  .  | .|. .|||||||| ||  ||   |    . |.|.||.|||| . |||   |.. |  .||.. .||||||   | ..
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAF-CDLVWSDPEDI-SGWAVSPRGAGYLFGNSv
||||.||  .| .   .     ||  . ..|.. ...||.|||.|  .. . |.|.| | .. |   ..  |..|||| ..  ||    ||  |.||   
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd.

tqegtcyvihcALVPLvtitvsfMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIK
           ||  |       .   .. |. ||||.|..| ... ..||||..||| || .  | |... ..
...........alrkl.......ldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvn

subfamily_PPPLV_pd Subfamily PPPLV 22-292 1.1e-53 175.4 In-house 2-277 (290) alignment
Range on Protein: 22-292
Range on HMM: 2-277/290.0
LKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLE----ELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQI
|  |||   | |..| .. .. .|. | ||.||.. ||      |.||| ..  .|..|.||.|||| .|.|  . ||.||  || |. ||||||| . .
llslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesv

TQVYGFYDECMNKYGNA--NAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQI---RTIDRGIEIPHEGAF--CDLVWSDPEDISGWAV---SP
.. . .. |.. |.|.   ..|    .||| | .||.||..|.|||.|.   ..|  .|   . |   .. . .||    |..||||..    ..     
qesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelv

RGAGYLFGnsvTQEGTCYVIHCALVPlvtitvSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIK
  .|...     . || .|  .. .       .|.. |||. . |||.  ..||..  . ||.||.|. .||    . | ||. |
lneGfvdn...drrGtghvfsedale......aflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdk

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 37-217 1.5e-49 161.5 In-house 30-213 (287) alignment
Range on Protein: 37-217
Range on HMM: 30-213/287.0
SNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGnANA
. .  | .|.|..||||||. ||  .|   |. |.. |.|.||.||||  |||    |..|| .||.|. ||||||| ..| ..|||..| ..|..  . 
palleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeelkrkrq.erl

WRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEI--PHEGAFCDLVWSDPE-DISGWAVS-PRGAGYLFGNS
..   .||. |.. |......||.|||.||..|.||..... .       .||   ||.|.||| |  . ..   |.   .||..
ykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkk

subfamily_PPP7C_pd Subfamily PPP7C 37-180 5.7e-34 110.5 In-house 53-202 (383) alignment
Range on Protein: 37-180
Range on HMM: 53-202/383.0
SNVQPVYT----PVTVCGDIHGQFYDLEELF-RTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKY
 |.. | |     ||||||.||.. ||  .. . |   .. .||| |||||||  |.|    ||.|   ||... | |||||   .   |||  | ..||
pnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikevesky

--GNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSpEVKTLDQIRTIDRG
   ...  |   .||  | .|..||...| ||||.| .   |. .  |.| 
kvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiers

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 40-293 1.7e-53 174.5 In-house 39-277 (290) alignment
Range on Protein: 40-293
Range on HMM: 39-277/290.0
QPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYgNANAWRY
  | .|... ||||||. .| . |   |. |.  ..|.||.||||  |||    |. .| .|..|. ||||||| |.. ..|||..| . |  ... |. 
leveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeelarkr.gsrlwkq

CCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRG--IEIPHEGAFCDLVWSDPED--ISGWAVS-PRGAGYLFGNSVTQEgtcyvihcalvpl
  .||. |.. | .....||.|||.|..... . .... .       .||   ||.|.||.       |.   |.   .||... ..             
yqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkgldd.............

vtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
      ...   |.|| |||.. .|| ...||..||||.||| |. .  |. .|. . .
......llkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvse

subfamily_PPP5C_pd Subfamily PPP5C 43-309 4.5e-71 232.5 In-house 64-311 (322) alignment
Range on Protein: 43-309
Range on HMM: 64-311/322.0
YTPVTVCGDIHGQFYDLEELFRTGGQI-PDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGNAnAWRYCC
 . .||||||||||||| ..|.  |.  .. .|.| ||||||| .|.|.   ||..|  |||.. | |||||| .. ..||| .|. .|| ..       
tkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytek.vadlft

KVFDLLTIAAIIDNQVLCVHGGLS-PEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDISGWAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvs
.||. | .| .|...|| |||||   .  |||..|.|||  . |.||....|.||||.. .| . | || |  ||  ||..                   
evfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkk...................

FMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDANLEGKeAKLFQAVPD
|.. |||.|| |.|.. .||.. . | .|.||.|||||| . || .... .....|. |  | |.||. 
flkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklk.fktfeaveh

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 43-199 1.6e-40 132.4 In-house 6-167 (263) alignment
Range on Protein: 43-199
Range on HMM: 6-167/263.0
YTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGNANA----WR
 .|. .||| |||. ||  .| . |    | |.|.||.|||| .|||    |..||   | |. ||||||| . | . |||. |  ...   .     . 
qapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvyn

YCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHE-GAFCDLVWSDPED
.  .||  . ..||. ...||.|||.|| .|.||.||.|   .|  .     |||.|.||| 
hfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek

Metallophos Calcineurin-like phosphoesterase 45-254 3.2e-41 134.8 Pfam-A 2-196 (200) alignment
Range on Protein: 45-254
Range on HMM: 2-196/200.0
PVTVCGDIHGQFYDL----EELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRL--LTLKAKYPNKITLLRGNHESRQITQVYGFYDECM----------
...|.||.||...||    ..|.. ... . . ..|.||.|||| .|.||. .|  | || ..|... ||||||||......|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------NKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIrtidrgieiphegafcdlvwsdpedisgwav
                       ..... .|.......|..| ..|..|...|..||.||.. .. |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgagylfgnsvtqegtcyvihCALVPLVTITVSFMHLNNLKLICRAH
                       ..       .  .   ....|..|.|
.......................gselfgpdalekllekygvdlvlrGH

PPP_2 46-221 4.7e-73 238.1 In-house 1-181 (198) alignment
Range on Protein: 46-221
Range on HMM: 1-181/198.0
VTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKVFD
||||||.|||..|| .||..|...|...|.|.||.||||..|||... ||.|| .||....||||||||.....||||..|...|.|..........||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

LLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDL-----VWSDPEDISGWAVSPRGAGYLFGNSVTQE
||..||.||..||.||||||.|.|.||||....| ||.|.||...||     .....|. ...| | ||||.|||..||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvtee

PPP_4 46-221 9.5e-71 230.9 In-house 1-180 (197) alignment
Range on Protein: 46-221
Range on HMM: 1-180/197.0
VTVCGDIHGQFYDL-EELFRTGGQIP-DTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKyGNANAWRYCCKV
|||.||||||..||  .|...||. . ..||||.||.||||..|||... || || .||....||||||||......|||..|...|  ..........|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIP-HEGAFCDLV-WSDPE-DISGWAVSPRGAGYLFGNSVTQE
||||..||.||..||.||||||.|...||.|..|.| ||.| .|....||  ||||. . .|.| | ||||.|||..||..
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtek

PPP_5_Dcr2 46-221 7.1e-70 228.0 In-house 1-182 (199) alignment
Range on Protein: 46-221
Range on HMM: 1-182/199.0
VTVCGDIHGQFYDL-EELFRTGGQIP-DTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKV
||||||.|||..||  .||..||. . ...|||.||.||||..|||... || || .||....|||||||..|....|||..|...||...........|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIP-HEGAFCDLV-WSDPE-DISG-WAVSPRGAGYLFGNSVTQE
|| |..||.||..||.||||||||.|...... |.| |||| ..|  .||. ||||. . .| .. | ||||.|||..||..
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtek

subfamily_YNL217W_pd Subfamily YNL217W 47-116 8.7e-06 18.4 In-house 13-78 (235) alignment
Range on Protein: 47-116
Range on HMM: 13-78/235.0
TVCGDIHGQFYDLEELFR--TGGQIPDTSYVFMGDFVDRGYYSLETFTRLltlkakYPNKITLLRGNHESRQ
 | ||.|| . .| ||.   .||. ..   |..||....|  |.|.   .        ..   ..||||   
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelv

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 72-293 1.1e-59 195.2 In-house 101-303 (317) alignment
Range on Protein: 72-293
Range on HMM: 101-303/317.0
TSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGNaNAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTL
  |.|.||.|||| .|.|  . |..|| .||.|..||||||||| . . |||| |. ..| . . .    ..|  | ..|......||.|||.| |.  |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIRTIDRGIEIPHEGAFCDLVWSDPE-DISGWAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLV
.|. ...| ..||  |  .||.|.||. ...|.. |.|||| .||..  .|                   |..  .|.|. ||||.|..| ... |..||
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavke...................flkkldldlvvrahqvvedGyeffadrklv

TVWSAPNYCYRCGNIASILIIKD
|..|||.|| .  |||..| ...
tifsapsycGqldniaavlsvdk

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 73-292 3.9e-46 150.7 In-house 121-321 (339) alignment
Range on Protein: 73-292
Range on HMM: 121-321/339.0
SYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYgNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLD
 |.|.||.|||| .|.|    | .||  ||..| ||||||||| .   |||| |   .| .|. .    ..|... ..|.|.| ..|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRTIDRGIEIPHEGAFCDLVWSDPEDI-SGWAVSPRGAGYLFGNSvtqegtcyvihcALVplvtitvSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVT
|.  . | .|||  | . || |.||.    |.  | ||| ..||              ||        .|..  .|... | ||.| .| ...  .||||
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgpp............alr.......aflkkldlqmvirghqvvedgyeffdgrrlvt

VWSAPNYCYRCGNIASILIIK
..|||||| .  | |... | 
ifsapnycgqndntaavfsid

subfamily_PPP7C_pd Subfamily PPP7C 190-284 6.7e-09 27.9 In-house 238-314 (383) alignment
Range on Protein: 190-284
Range on HMM: 238-314/383.0
CDLVWSDPEDISG-WAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGN
 |..||||.  .| .. . ||.|  ||  ||..                   ...  ||||. |.|.  .|| ... |....|..|| ||     |
ldilwsdpkakeGckpntlrGgGsyfGpdvtkk...................llqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsn

subfamily_PPP2C_pd Subfamily PPP2C 237-294 6.7e-22 71.0 In-house 218-275 (290) alignment
Range on Protein: 237-294
Range on HMM: 218-275/290.0
ITVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDA
|. .| . |.|.|| |||||| || ....|...||..||||||||||| |.|| ..|.
isekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddk

subfamily_PPG1_pd Subfamily PPG1 237-294 1.1e-20 67.1 In-house 228-285 (300) alignment
Range on Protein: 237-294
Range on HMM: 228-285/300.0
ITVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDA
..  |.. |... | |||||..|| . .||..| |||||||||||||| |||| ... 
vvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyek

PPP_3 237-295 1e-19 63.6 In-house 204-262 (271) alignment
Range on Protein: 237-295
Range on HMM: 204-262/271.0
ITVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDAN
.| .|.. |.||||.|||.|..|| ....|...|||.||||||.|..| ..|| ...|.
vteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleeal

PPP_1 237-288 5.3e-16 51.7 In-house 210-261 (264) alignment
Range on Protein: 237-288
Range on HMM: 210-261/264.0
ITVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASI
.| .|.. ||||||.|||....|| ........||..||.||.....| ...
vtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgay

PP2Ac_SM00156 238-293 1.5e-16 53.2 In-house 203-258 (271) alignment
Range on Protein: 238-293
Range on HMM: 203-258/271.0
TVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
.  |.. ||||||.|||..|.|| ....|..|||..||||||....| |..| ...
vkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkvek

subfamily_PPP1C_pd Subfamily PPP1C 239-293 4.4e-16 51.9 In-house 213-267 (282) alignment
Range on Protein: 239-293
Range on HMM: 213-267/282.0
VSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
 .|.. |.|.||.||||.|..| ... ...||||.|||||| . .| ...| ...
ekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvde

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 244-293 6e-13 41.4 In-house 221-270 (287) alignment
Range on Protein: 244-293
Range on HMM: 221-270/287.0
LNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
  ...|| |||....|| ...||.|||||.||| |. .  |..... ...
kldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvsk

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 246-292 1.3e-07 24.6 In-house 197-243 (263) alignment
Range on Protein: 246-292
Range on HMM: 197-243/263.0
NLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIK
.. || ||||.|  |  .. |.||.||.||  |     | |......
didlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvn