Gene PPP6C-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP6C
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP184_AA protein Get Run
AqueP184_AA_1-311 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP2C_pd Subfamily PPP2C 2-221 2.4e-109 358.0 In-house 2-221 (290) alignment 
Range on Protein: 2-221
Range on HMM: 2-221/290.0
SELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKY
..||..||  |.|. |.|.|.|.||. . ..| .|||||.| .|||||||.||||.|| |||. ||. ||| |.|.||.|||||||.|| | | .|| .|
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PNKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDIS
...||.||||||||||||||||||||. |||||| |.|  ..|| |...|..|.|..|.||||||...|||.||..||  |.||||..|||.||||.| .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWAVSPRGAGYLFGNSVTQE
||..||||||| ||. ....
gwgisprgagytfgkdisek
0049330 Metallo-dependent phosphatases 2-294 1.8e-101 332.3 In-house 15-288 (309) alignment 
Range on Protein: 2-294
Range on HMM: 15-288/309.0
SELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKY
| ||..||| .|...|.|.||..|.......|..|.|....  ...|.||||||..||..|..  | .|.. .||.||.||||..|||....|| || .|
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PNKITLLRGNHESRQITQVYGFYDECMNKYGnANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPE-DI
|....|||||||.|.....|||.||.. ||| |. |........ | .||.|....|||||||||....||||| ..| .|||..| .|||.||||  ..
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

SGWAVSPRGAGYLFGNSVTQegtcyvihcalvplvtitvSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDA
.|.| .|||.|..||  ...                   .|...|.|.||.|.|..|..|....||..|.||.||||||.|.|| ...|.|.. 
egfapnprglgvvfghtave...................rflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleided
subfamily_PPP6C_pd Subfamily PPP6C 3-312 2.5e-181 594.2 In-house 1-289 (290) alignment 
Range on Protein: 3-312
Range on HMM: 1-289/290.0
ELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYP
|||.||||||||.||.||.||||||.|.||||||||||||..||||||||||||||||||||||||.|||||||.|||||||||||||||||||||||||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

NKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDISG
..|||||||||||||||||||||||.|||||||||.||.|||||||||||||.|||||||||||.||||||||.|.| .||||.|||||||||||||.. 
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDANleGKEAK
|||||||||||||..||.|                   |.|.|||||||||||||.||.|||||..||||||||||||||||.||||...||.   .|||
wavsprgagylfgskvtke...................fvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae..ereak

LFQAVPDNER
||.||||.||
lfkavpdeer
subfamily_PPP4C_pd Subfamily PPP4C 3-308 1.8e-139 456.9 In-house 2-286 (288) alignment 
Range on Protein: 3-308
Range on HMM: 2-286/288.0
ELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYP
.||. ||  ..|. ..|.|.|.||  . ..|.|||||| | .||||||||||||||| |||. ||..|.|.|.|.|||||||.||.|||  ||.||..||
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

NKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDISG
..|||.|||||||||||||||||||..|||.|| ||||..|||.|..|||||....||||||||...|||.||.||| .|.||||..|||.||||||..|
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIkDANLEgKEAK
|||||||||||||..|...                   |.. |...||||||||| || |..|.....||||||||||||||.|.|| . |..|. |. |
wavsprgagylfgsdvveq...................fneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaailel.deeld.kdfk

LFQAVP
.|.|..
ifeaaa
0045823 Metallo-dependent phosphatases 3-311 3.2e-110 361.9 In-house 29-328 (473) alignment 
Range on Protein: 3-311
Range on HMM: 29-328/473.0
ELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYP
 ||..||  ||...|.|..|.||.|.....| .|.|....  ...|.||||||..||..|..  | .|.. .||.||.||||..|||.. .|| || |||
dldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikyp

NKITLLRGNHESRQITQVYGFYDECMNKYgNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDISG
....|||||||.|.....|||.||.. || ... ......... | .||.|....|.|||||||....|||||.|.| .|||..|...||.||||....|
gnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddg

--------WAVSPRGAGYLFGNSVtqegtcyvihcalvplvtiTVSFMHLNNLKLICRAHQLVHEGIKYMFDQR------LVTVWSAPNYCYRCGNIASI
        .  ||||||||||  .                   .  |.. |.|.||.|.|. | ||....|| .      ..||.||||||.|.|| |..
dgllrlrffgnsprgagylFgpda...................veeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAv

LIIKDaNLegKEAKLFQAVPDNE
|.| . .|   . ..|...|.  
lvide.dl..isfiqfdpsphpl
0053225 Metallo-dependent phosphatases 3-294 4.1e-99 324.6 In-house 8-280 (293) alignment 
Range on Protein: 3-294
Range on HMM: 8-280/293.0
ELDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYP
 || .||| .....|.|.||..|.......|..|.|....  ...|.|||||...||..|..  | .|.. .||.||.||||..|||....|| ||..||
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp

NKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDISG
....|||||||.......|||.||.. |||.|. |........ | .||.|....|.|||||||.. .||||| |.| ..||.||...||.|||| ..||
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsg

WAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDA
|. |.||.|..||  ....                   |...|.|.||.|.||.|..|....||..||||.|||||..|.|| ...|.... 
wlpsyrglgvvfghtavlr...................flkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeg
subfamily_PPG1_pd Subfamily PPG1 4-220 2.8e-95 312.1 In-house 1-230 (300) alignment 
Range on Protein: 4-220
Range on HMM: 1-230/300.0
LDEWIELAKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPN
||| .|  .|.. | |  .|.|.| . .||..||||. . .|||| ||.||||||. |.|. |||.||| |.|.||.||||.||.|| . |..|| .|| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

KITLLRGNHESRQITQVYGFYDECMNKY-GNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPE----
.|||||||||||||||||||| ||..|| ||.. |.|  ..|| |..|||||... ||||||||.|...|||. .||  |.|.|||..||.|||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DISG--WAVSPRGAGYLFGNSVTQ
      | .|  . ||.||||| .|..|..
ptldhpdregqhfvvsqrgagysygkdvve
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 11-293 6e-78 254.9 In-house 18-282 (298) alignment 
Range on Protein: 11-293
Range on HMM: 18-282/298.0
AKKCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRG
.| .. ..|....||.. . ... . . .  | .|..||||||||. ||  ||  .|  ||. |.|.||.|||| ..||. . ||. |.||||.. ||||
kkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrG

NHESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPED-ISGWAVSPRG
|||  .| .|||||.|| ..| . . .    .||. | ..|.| ...||.|||||...|.|||.|.. | .. ..|    ||.|.|||. ..||| . ||
nheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrG

AGYLFGNSVTQEgtcyvihcalvplvtiTVSFMhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
... ||. | ..                 .. .   .. |..||||.| .| ... ...|||..|||.|| .  | |.......
vsvvfGedvvkd................llekl...didlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvde
subfamily_PPP1C_pd Subfamily PPP1C 13-220 3.9e-76 248.9 In-house 6-213 (282) alignment 
Range on Protein: 13-220
Range on HMM: 6-213/282.0
KCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNH
|   |.|.|...|...  ..||... .  .  ||...||||||..||  || |.|  |...|.|.||.||||  |||| . ||..| |||... ||||||
kevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnh

ESRQITQVYGFYDECMNKYGNAnAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPE-DISGWAVSPRGAG
|| .|...||||||| ..|..   |.   .||. | .||..|...||||||||||.| |.|||.| | .|.|..|  |||.||||. .. ||. . ||  
esasinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvs

YLFGNSVTQ
. ||..| .
ftfgkdvve
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 13-293 3.2e-68 223.3 In-house 3-271 (284) alignment 
Range on Protein: 13-293
Range on HMM: 3-271/284.0
KCQY-LTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQI------PDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKI
.||  |.|.|| .||    .|. .|.  . . .||...||||||| ||  |.   |         .. |.|.||.|||| .|.|  | |...| ..|.|.
ncqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkv

TLLRGNHESRQITQVYGFYDECMNKYGNAnAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPE-DISGWA
.||||||||| . . |||| || ..| .|  .      |  . ..|.......|.|||.| ..  |.|.  ..| |.||  |  .||.|.||| ...|..
fllrgnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyk

VSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
 |||||| .||..  .|                   |..  .|.|. ||||.| .| ... |..|||..||| || .  |||..| ...
esprgagkvfgakavke...................flkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvde
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 13-290 6.9e-63 205.7 In-house 19-280 (297) alignment 
Range on Protein: 13-290
Range on HMM: 19-280/297.0
KCQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNH
 .. .||. . || |   |..  . ..  | .|. ||||||||| ||  ||. ||  | . |.|.||.|||| .|.||   ||. | |.| .. ||||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESRQITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSP---EVKTLDQIRTIDRGIEiPHEGAFCDLVWSDP-EDISGWAVSPR
|   . .|||||.|| ..|     .     ||. | .. .| ...||.||||||   .  ||| .| |.|  |  .|.  .||.|.||   .||.    |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfmenqr

GAGYLFGNSVtqegtcyVihcalvplVTITVSFmhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILI
|||  ||          |        . .   |    .| |.|||||.|..| ...  ..|||..||| || .  | |... 
gagcgfgrda.......v........lklcsef....kldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafms
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 13-293 3.1e-52 170.7 In-house 17-280 (307) alignment 
Range on Protein: 13-293
Range on HMM: 17-280/307.0
KCQYlTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNH
| || | .|....      ..  |  .  .  |. | ||.|||| || ..|   |. |.| ||| ||.||||  |||.   |.| |  ||..| ||||||
kiqy.tkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnh

ESRQITQVYGFYDECMNKYGN--ANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPED-ISGWAVSPRG
|  .. . ||||.||.    .   . |    ..|. | |.|.|  ..||.|||||| .  ||..|   . |  |  |   |..|.||.  .  |  | ||
eiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrg

AGYLFGNSVTQEgTCYVIhcalvplvtitvsfmhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
.|. ||  | ..  |  .                   ..|| ||||.. .|   .  ..|.|..||| ||    |   .| . .
sgftfgtnvidd.vckrl..................gveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvde
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 13-67 1.2e-09 30.7 In-house 4-59 (317) alignment 
Range on Protein: 13-67
Range on HMM: 4-59/317.0
KCQ-YLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGG
|||  ..|.|| .||    .|. .|     . .|||..||||||| ||  |.   |
kcqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_PPZ_pd Subfamily PPZ 14-294 2.5e-62 204.1 In-house 22-283 (300) alignment 
Range on Protein: 14-294
Range on HMM: 22-283/300.0
CQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHE
   | ..|. ..|    .|.| . ..  .  .| . ||.|||. ||  ||   |  | . |.|.||.||||  ||||   ||  | |||... |||||||
nvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhe

SRQITQVYGFYDECMNKyGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDIS-GWAVSPRGAGY
  ..|.||||||||  .  | . |.     |. | .|||.  ...|||||||| ....|.|| . |  ..|  |   ||.|||| | |  |    ||  |
canvtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsy

lfgnsvtqegtCYVIhcalvplVTITvSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDA
           ||         |.|   |.    . |.|||| .| .| ... |. ||||.||||||    |  ... . . 
...........cynk.......vain.kflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvseg
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 14-297 2.9e-62 203.6 In-house 3-266 (280) alignment 
Range on Protein: 14-297
Range on HMM: 3-266/280.0
CQYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHE
|. .|  |.  .   |  ...||||.    .|. | |||| |. |.. ||   |..|.   .|.||.||||   .| .  |. || .| ..| |||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECMNKYGNANAWRYCcKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPED-ISGWAVSPRGAGY
.  . ..|||| ||  ||| .  | .   .|. . ....| ..|||.|||||||.  || || | | .|    | . ||.|||| .   ||  | ||  |
tpsvnkiygfyvecqykygvglwwdfq.scfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGNSVTQEgTCYVIhcalvplvtitvsfmhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIkDANLE
.||. | .. .|  .                  .. || ||||.|..| . |  .||.||.| |||| .  | |..... .|||.
mfgkgvveq.acksl..................eidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvcl.nanlq
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 15-291 1e-53 175.5 In-house 4-286 (302) alignment 
Range on Protein: 15-291
Range on HMM: 4-286/302.0
QYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQ-----------IPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPN
. ....|| .|.. | .|| .|...  . .|||. ||||||| ||  .. .  .                .||.||.||||. |.|  . ...||  ||.
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

KITLLRGNHESRQITQVYGFYDECMNKYGNAN---AWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGI-EIPHEGAFCDLVWSDPED
.  |||||||.. |   ||| .|  |..|...    |.   .||  . .||.. ...||||||.|| ...|..|. |.| . |. ..    ||...|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

ISGWAVSPRGAGYLFgNSVTQEGTCYviHCALVplvtitVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILII
. . |. ..   | . | | .   ..    | |        . .  ||||| |||| . || |.. |..|.|..|||.|     |  ..| .
vqllaavsekPkyak.nivrglsvvf..neaav......rdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 15-291 1.2e-53 175.3 In-house 5-287 (302) alignment 
Range on Protein: 15-291
Range on HMM: 5-287/302.0
QYLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQ-----------IPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPN
. ....|| .|.. | .|| .|...  . .|||. ||||||| ||  .. .  .                .||.||.||||. |.|  . ...||  ||.
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

KITLLRGNHESRQITQVYGFYDECMNKYGNAN---AWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGI-EIPHEGAFCDLVWSDPED
.  |||||||.. |   ||| .|  |..|...    |.   .||  . .||.. ...||||||.|| ...|..|. |.| . |. ..    ||...|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

ISGWAVSPRGAGYLFgNSVTQEGTCYviHCALVplvtitVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILII
. . |. ..   | . | | .   ..    | |        . .  ||||| |||| . || |.. |..|.|..|||.|     |  ..| .
vqllaavsekPkyak.nivrglsvvf..neaav......rdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_PPP3C_pd Subfamily PPP3C 16-297 1.3e-77 254.5 In-house 40-315 (452) alignment 
Range on Protein: 16-297
Range on HMM: 40-315/452.0
YLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESR
 |.|..  |. . ...|| .|...  | .|.||.|||||||||| .||  ||.  .|.|.|.||.|||||.|.|.   |..|| .||... |||||||.|
rleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecr

QITQVYGFYDECMNKYGNaNAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEdisgwavsprgagYLFG
 .|. . | .||  ||.. . .  |.. || | .||....| ||||||||||.|.||.|...||  |.|. |..|||.||||                .|
hlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPl.............edyg

NSVTQEG--TCYVIHCALVPLVTITVSFMHLNNLKLICRAHQLVHEGIKYMFD------QRLVTVWSAPNYCYRCGNIASILIIKDANLE
.. |.|      |  |. .   . ...|.. |.|  | |||.  ..| .   .        |.|..|||||.    | |..| ... ...
eekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvmn
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 16-293 2.7e-67 220.1 In-house 23-282 (299) alignment 
Range on Protein: 16-293
Range on HMM: 23-282/299.0
YLTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESR
 . |.||..||.   . ..... .  | .|. ||||||||. ||  .|   |  ||. ..|.||.||||   ||. | ||  | |||... .||||||  
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecp

QITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPED-ISGWAVSPRGAGYLF
 | .|||||.|| ..|  .  |    . |. . .. .| ...||.||||||...||||.| . |  . |      ||.|.||.. . .|    ||  |.|
ainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvf

GNSVTQEgtcyvihcalvplV--TItvsfmhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
|. | ..             |  ..        .. |..||||.| .| ... ...|||..||| || .  | |.|. . .
gqdvvad.............visrl........didlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvde
PPP_3 17-221 7.5e-89 290.3 In-house 2-207 (271) alignment 
Range on Protein: 17-221
Range on HMM: 2-207/271.0
LTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQ
|.|||||.|.. . ..| .|||.. . .|||||||||||..|| |||..||..|.|.|.|.||.||||..|||... ||.|| |||....||||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDL-VWSDPEDISGWAVSPRGAGYLFG
|..||||..|...|.|... ......||.||..||.||..||.|||||||..|.||||....| ||.|.||...|| ..||||. .|.. |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

NSVTQE
..||.|
pdvtee
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 17-297 7.2e-70 228.4 In-house 8-268 (281) alignment 
Range on Protein: 17-297
Range on HMM: 8-268/281.0
LTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQ
.|..|....   |  .. ||...  . .|..| ||.|.|| ||..||   |..|.. .||.||.||||  |||..  |.||| .|...| |||||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

ITQVYGFYDECMNKYGNaNAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPED-ISGWAVSPRGAGYLFG
. ..|||| ||. |||  . |    . |. | |.| |...|||.|||||||. .||..| . . |. .. |   ||.|.||..   .|  | ||....||
vnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

NSVTQEgTCYVIhcalvplvtitvsfmhlnNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIkDANLE
..| .. .|  .                  .. || ||||.|..|.. .  ..|.||.|.||||    | |..| . |..|.
knvvdd.vckrl..................eveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkv.detlg
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 17-293 1.1e-68 224.4 In-house 6-263 (280) alignment 
Range on Protein: 17-293
Range on HMM: 6-263/280.0
LTENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQ
. | ..... . . ..|. .. .  | .||.||||.|||. ||  ||   .  ||. |.|.||.|||| . ||    ||. |..|||.. .||||||  .
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

ITQVYGFYDECMNKYGNAnAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPE-DISGWAVSPRGAGYLFG
| . |||.||....| .|  .    ...| | ..|..  ..||.|||||.....||... . | .. ..|    ||.|.||| ...||| ..||. ..||
inrkygfkdevkrrysla.lynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifg

NSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
. | ..                   .... .. ||.| ||.| .| ... |..||||.|||.|.    | |..||...
anvvkd...................ltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivde
PPP_1 18-221 2.8e-86 282.0 In-house 2-213 (264) alignment 
Range on Protein: 18-221
Range on HMM: 2-213/264.0
TENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQI
.|.||..|.. . .|| .|.|.. | ...||||||||||.|| .||..||. |.|.|.|.||.||||..|.|... ||.|| |||....||||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDL--------VWSDPEDISGWAVSPRG
|.||||..|...|..... ......|||.|..||.||...|.||||||||...|||||...| .|.|.||..|||        ...|.|. ...| |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYLFGNSVTQE
||||||..||..
agylfgkdvtek
PP2Ac_SM00156 18-221 5.7e-79 257.9 In-house 2-205 (271) alignment 
Range on Protein: 18-221
Range on HMM: 2-205/271.0
TENELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQI
...|...|.. |...| .|.|.  |..||||.||||||..|| .|....|. |.. |||.||.||||..|.|. . |..|| .||.|..||||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECMNKYgNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDP-EDISGWAVSPRGAGYLFGN
...|||..|...|| .....  . ..|.||..||..|...||.|||||||...||.|| ..|  |.|.|| ..||.|||| .. .|.. | ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

SVTQE
....|
davke
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 21-292 2.5e-55 180.9 In-house 7-261 (284) alignment 
Range on Protein: 21-292
Range on HMM: 7-261/284.0
ELKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQV
... |  ...... ..  .  | .|. .|||||||| ||  ||   |    . |.|.||.|||| . |||   |.. |  .||.. .||||||   | ..
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECMNKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAF-CDLVWSDPEDI-SGWAVSPRGAGYLFGNSv
||||.||  .| .   .     ||  . ..|.. ...||.|||.|  .. . |.|.| | .. |   ..  |..|||| ..  ||    ||  |.||   
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd.

tqegtcyvihcALVPLvtitvsfMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIK
           ||  |       .   .. |. ||||.|..| ... ..||||..||| || .  | |... ..
...........alrkl.......ldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvn
subfamily_PPPLV_pd Subfamily PPPLV 22-292 1.1e-53 175.4 In-house 2-277 (290) alignment 
Range on Protein: 22-292
Range on HMM: 2-277/290.0
LKKLCDYVCDLLLEESNVQPVYTPVTVCGDIHGQFYDLE----ELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQI
|  |||   | |..| .. .. .|. | ||.||.. ||      |.||| ..  .|..|.||.|||| .|.|  . ||.||  || |. ||||||| . .
llslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesv

TQVYGFYDECMNKYGNA--NAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQI---RTIDRGIEIPHEGAF--CDLVWSDPEDISGWAV---SP
.. . .. |.. |.|.   ..|    .||| | .||.||..|.|||.|.   ..|  .|   . |   .. . .||    |..||||..    ..     
qesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelv

RGAGYLFGnsvTQEGTCYVIHCALVPlvtitvSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIK
  .|...     . || .|  .. .       .|.. |||. . |||.  ..||..  . ||.||.|. .||    . | ||. |
lneGfvdn...drrGtghvfsedale......aflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 37-217 1.5e-49 161.5 In-house 30-213 (287) alignment 
Range on Protein: 37-217
Range on HMM: 30-213/287.0
SNVQPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGnANA
. .  | .|.|..||||||. ||  .|   |. |.. |.|.||.||||  |||    |..|| .||.|. ||||||| ..| ..|||..| ..|..  . 
palleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeelkrkrq.erl

WRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEI--PHEGAFCDLVWSDPE-DISGWAVS-PRGAGYLFGNS
..   .||. |.. |......||.|||.||..|.||..... .       .||   ||.|.||| |  . ..   |.   .||..
ykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkk
subfamily_PPP7C_pd Subfamily PPP7C 37-180 5.7e-34 110.5 In-house 53-202 (383) alignment 
Range on Protein: 37-180
Range on HMM: 53-202/383.0
SNVQPVYT----PVTVCGDIHGQFYDLEELF-RTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKY
 |.. | |     ||||||.||.. ||  .. . |   .. .||| |||||||  |.|    ||.|   ||... | |||||   .   |||  | ..||
pnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikevesky

--GNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSpEVKTLDQIRTIDRG
   ...  |   .||  | .|..||...| ||||.| .   |. .  |.| 
kvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiers
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 40-293 1.7e-53 174.5 In-house 39-277 (290) alignment 
Range on Protein: 40-293
Range on HMM: 39-277/290.0
QPVYTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYgNANAWRY
  | .|... ||||||. .| . |   |. |.  ..|.||.||||  |||    |. .| .|..|. ||||||| |.. ..|||..| . |  ... |. 
leveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeelarkr.gsrlwkq

CCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRG--IEIPHEGAFCDLVWSDPED--ISGWAVS-PRGAGYLFGNSVTQEgtcyvihcalvpl
  .||. |.. | .....||.|||.|..... . .... .       .||   ||.|.||.       |.   |.   .||... ..             
yqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkgldd.............

vtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
      ...   |.|| |||.. .|| ...||..||||.||| |. .  |. .|. . .
......llkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvse
subfamily_PPP5C_pd Subfamily PPP5C 43-309 4.5e-71 232.5 In-house 64-311 (322) alignment 
Range on Protein: 43-309
Range on HMM: 64-311/322.0
YTPVTVCGDIHGQFYDLEELFRTGGQI-PDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGNAnAWRYCC
 . .||||||||||||| ..|.  |.  .. .|.| ||||||| .|.|.   ||..|  |||.. | |||||| .. ..||| .|. .|| ..       
tkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytek.vadlft

KVFDLLTIAAIIDNQVLCVHGGLS-PEVKTLDQIRTIDRGIEIPHEGAFCDLVWSDPEDISGWAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvs
.||. | .| .|...|| |||||   .  |||..|.|||  . |.||....|.||||.. .| . | || |  ||  ||..                   
evfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkk...................

FMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDANLEGKeAKLFQAVPD
|.. |||.|| |.|.. .||.. . | .|.||.|||||| . || .... .....|. |  | |.||. 
flkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklk.fktfeaveh
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 43-199 1.6e-40 132.4 In-house 6-167 (263) alignment 
Range on Protein: 43-199
Range on HMM: 6-167/263.0
YTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGNANA----WR
 .|. .||| |||. ||  .| . |    | |.|.||.|||| .|||    |..||   | |. ||||||| . | . |||. |  ...   .     . 
qapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvyn

YCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHE-GAFCDLVWSDPED
.  .||  . ..||. ...||.|||.|| .|.||.||.|   .|  .     |||.|.||| 
hfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek
Metallophos Calcineurin-like phosphoesterase 45-254 3.2e-41 134.8 Pfam-A 2-196 (200) alignment 
Range on Protein: 45-254
Range on HMM: 2-196/200.0
PVTVCGDIHGQFYDL----EELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRL--LTLKAKYPNKITLLRGNHESRQITQVYGFYDECM----------
...|.||.||...||    ..|.. ... . . ..|.||.|||| .|.||. .|  | || ..|... ||||||||......|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------NKYGNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIrtidrgieiphegafcdlvwsdpedisgwav
                       ..... .|.......|..| ..|..|...|..||.||.. .. |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgagylfgnsvtqegtcyvihCALVPLVTITVSFMHLNNLKLICRAH
                       ..       .  .   ....|..|.|
.......................gselfgpdalekllekygvdlvlrGH
PPP_2 46-221 4.7e-73 238.1 In-house 1-181 (198) alignment 
Range on Protein: 46-221
Range on HMM: 1-181/198.0
VTVCGDIHGQFYDLEELFRTGGQIPDTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKVFD
||||||.|||..|| .||..|...|...|.|.||.||||..|||... ||.|| .||....||||||||.....||||..|...|.|..........||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

LLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIPHEGAFCDL-----VWSDPEDISGWAVSPRGAGYLFGNSVTQE
||..||.||..||.||||||.|.|.||||....| ||.|.||...||     .....|. ...| | ||||.|||..||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvtee
PPP_4 46-221 9.5e-71 230.9 In-house 1-180 (197) alignment 
Range on Protein: 46-221
Range on HMM: 1-180/197.0
VTVCGDIHGQFYDL-EELFRTGGQIP-DTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKyGNANAWRYCCKV
|||.||||||..||  .|...||. . ..||||.||.||||..|||... || || .||....||||||||......|||..|...|  ..........|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIP-HEGAFCDLV-WSDPE-DISGWAVSPRGAGYLFGNSVTQE
||||..||.||..||.||||||.|...||.|..|.| ||.| .|....||  ||||. . .|.| | ||||.|||..||..
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtek
PPP_5_Dcr2 46-221 7.1e-70 228.0 In-house 1-182 (199) alignment 
Range on Protein: 46-221
Range on HMM: 1-182/199.0
VTVCGDIHGQFYDL-EELFRTGGQIP-DTSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGNANAWRYCCKV
||||||.|||..||  .||..||. . ...|||.||.||||..|||... || || .||....|||||||..|....|||..|...||...........|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDLLTIAAIIDNQVLCVHGGLSPEVKTLDQIRTIDRGIEIP-HEGAFCDLV-WSDPE-DISG-WAVSPRGAGYLFGNSVTQE
|| |..||.||..||.||||||||.|...... |.| |||| ..|  .||. ||||. . .| .. | ||||.|||..||..
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtek
subfamily_YNL217W_pd Subfamily YNL217W 47-116 8.7e-06 18.4 In-house 13-78 (235) alignment 
Range on Protein: 47-116
Range on HMM: 13-78/235.0
TVCGDIHGQFYDLEELFR--TGGQIPDTSYVFMGDFVDRGYYSLETFTRLltlkakYPNKITLLRGNHESRQ
 | ||.|| . .| ||.   .||. ..   |..||....|  |.|.   .        ..   ..||||   
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 72-293 1.1e-59 195.2 In-house 101-303 (317) alignment 
Range on Protein: 72-293
Range on HMM: 101-303/317.0
TSYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYGNaNAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTL
  |.|.||.|||| .|.|  . |..|| .||.|..||||||||| . . |||| |. ..| . . .    ..|  | ..|......||.|||.| |.  |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIRTIDRGIEIPHEGAFCDLVWSDPE-DISGWAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLV
.|. ...| ..||  |  .||.|.||. ...|.. |.|||| .||..  .|                   |..  .|.|. ||||.|..| ... |..||
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavke...................flkkldldlvvrahqvvedGyeffadrklv

TVWSAPNYCYRCGNIASILIIKD
|..|||.|| .  |||..| ...
tifsapsycGqldniaavlsvdk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 73-292 3.9e-46 150.7 In-house 121-321 (339) alignment 
Range on Protein: 73-292
Range on HMM: 121-321/339.0
SYVFMGDFVDRGYYSLETFTRLLTLKAKYPNKITLLRGNHESRQITQVYGFYDECMNKYgNANAWRYCCKVFDLLTIAAIIDNQVLCVHGGLSPEVKTLD
 |.|.||.|||| .|.|    | .||  ||..| ||||||||| .   |||| |   .| .|. .    ..|... ..|.|.| ..|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRTIDRGIEIPHEGAFCDLVWSDPEDI-SGWAVSPRGAGYLFGNSvtqegtcyvihcALVplvtitvSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVT
|.  . | .|||  | . || |.||.    |.  | ||| ..||              ||        .|..  .|... | ||.| .| ...  .||||
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgpp............alr.......aflkkldlqmvirghqvvedgyeffdgrrlvt

VWSAPNYCYRCGNIASILIIK
..|||||| .  | |... | 
ifsapnycgqndntaavfsid
subfamily_PPP7C_pd Subfamily PPP7C 190-284 6.7e-09 27.9 In-house 238-314 (383) alignment 
Range on Protein: 190-284
Range on HMM: 238-314/383.0
CDLVWSDPEDISG-WAVSPRGAGYLFGNSVTQEgtcyvihcalvplvtitvsFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGN
 |..||||.  .| .. . ||.|  ||  ||..                   ...  ||||. |.|.  .|| ... |....|..|| ||     |
ldilwsdpkakeGckpntlrGgGsyfGpdvtkk...................llqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsn
subfamily_PPP2C_pd Subfamily PPP2C 237-294 6.7e-22 71.0 In-house 218-275 (290) alignment 
Range on Protein: 237-294
Range on HMM: 218-275/290.0
ITVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDA
|. .| . |.|.|| |||||| || ....|...||..||||||||||| |.|| ..|.
isekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddk
subfamily_PPG1_pd Subfamily PPG1 237-294 1.1e-20 67.1 In-house 228-285 (300) alignment 
Range on Protein: 237-294
Range on HMM: 228-285/300.0
ITVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDA
..  |.. |... | |||||..|| . .||..| |||||||||||||| |||| ... 
vvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyek
PPP_3 237-295 1e-19 63.6 In-house 204-262 (271) alignment 
Range on Protein: 237-295
Range on HMM: 204-262/271.0
ITVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKDAN
.| .|.. |.||||.|||.|..|| ....|...|||.||||||.|..| ..|| ...|.
vteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleeal
PPP_1 237-288 5.3e-16 51.7 In-house 210-261 (264) alignment 
Range on Protein: 237-288
Range on HMM: 210-261/264.0
ITVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASI
.| .|.. ||||||.|||....|| ........||..||.||.....| ...
vtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgay
PP2Ac_SM00156 238-293 1.5e-16 53.2 In-house 203-258 (271) alignment 
Range on Protein: 238-293
Range on HMM: 203-258/271.0
TVSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
.  |.. ||||||.|||..|.|| ....|..|||..||||||....| |..| ...
vkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkvek
subfamily_PPP1C_pd Subfamily PPP1C 239-293 4.4e-16 51.9 In-house 213-267 (282) alignment 
Range on Protein: 239-293
Range on HMM: 213-267/282.0
VSFMHLNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
 .|.. |.|.||.||||.|..| ... ...||||.|||||| . .| ...| ...
ekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvde
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 244-293 6e-13 41.4 In-house 221-270 (287) alignment 
Range on Protein: 244-293
Range on HMM: 221-270/287.0
LNNLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIKD
  ...|| |||....|| ...||.|||||.||| |. .  |..... ...
kldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 246-292 1.3e-07 24.6 In-house 197-243 (263) alignment 
Range on Protein: 246-292
Range on HMM: 197-243/263.0
NLKLICRAHQLVHEGIKYMFDQRLVTVWSAPNYCYRCGNIASILIIK
.. || ||||.|  |  .. |.||.||.||  |     | |......
didlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvn