Gene YNL217W in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily YNL217W
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP186_AA protein Get Run
AqueP186_AA_52-283 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_YNL217W_pd Subfamily YNL217W 48-273 3e-114 373.4 In-house 4-235 (235) alignment 
Range on Protein: 48-273
Range on HMM: 4-235/235.0
EDELKGRRLLVVGDVHGCYDELVQLLD-KAGGRDPGVLVVFVGDVCNKGPLNVESIRLVREVGGYCVRGNHDEICLL--EWLKHSEGAEPL--SDKFSWL
.....|.||||||||||.||||..||| |.||.|..||||.|||..|||| .||....||.....||.|||.|..||  .|.|...|||||  |.|||.|
avdvlgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyvrkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfl

-SRLSKEEMDWYFELPFSIHFPSREVLVIHAGLVPGVPIEEQSHHDLLHLRNVTFDLRTLTFSSERGGAYQEPHPQPWAQTWIGPDHVYFGHDAIRFLQR
 |.|||..|....||.||...||.|.||.|||||||...||.|....|.|||...|...|...||...|.|....|.||..|.|...||||||||..||.
esklskadmeyarelgfsldipsdellvvhaGlvpgkfleensidevlslrnllvdkknlsktseekeakqiariqlwaelWkgnakvyfGHdaieglql

YPFATGLDTGCVYGGHLTAVFDDEREKLIQVK
|.|||||||||||||.||||||||..||..||
yrfatGldtgCvyggsltavfddedkklvsvk
subfamily_PPP5C_pd Subfamily PPP5C 52-175 4.9e-06 18.8 In-house 63-186 (322) alignment 
Range on Protein: 52-175
Range on HMM: 63-186/322.0
KGRRLLVVGDVHGCYDELVQLLDKAGGRDPGVLVVFVGDVCNKGPLNVESI------RLVREVGGYCVRGNHDEICLLEWLKHSEgaEpLSDKFSW-LSR
....| | ||.|| . .|. .... |   .    .| ||  ..|   || |      .|.     .  ||||. . . .    ..  |    |..  .  
etkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfeg..e.vkakytekvad

LSKEEMDWyfeLPFSiHFPSREVLVIHAGLV
| .|  .|   ||.. |    .|||.| ||.
lftevfnw...lPla.hvinekvlvvhGGlf
0045823 Metallo-dependent phosphatases 53-283 1.8e-38 125.5 In-house 70-329 (473) alignment 
Range on Protein: 53-283
Range on HMM: 70-329/473.0
GrRLLVVGDVHGCYDELVQLLDKAGGRDPgVLVVFVGDVCNKGPLNVESIRLVRE------VGGYCVRGNHDEICLLEWLKhseGAEPLSDKFswLSRLS
. |. |.||.||..|.| .||.|.|  ..  ..||.||....|| ..| ..|...         ...||||..  |  ..    . . . .|.    .| 
m.rivviGDiHGqlddLlrllekigfppe.drlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglyg...fgdetleky..gedly

KEEMDWYFELPFSIHFPSrEVLVIHAGLVPGVPIEEQSHH--------------DLLHLRnVtfDLRTL--------TFSSERGGAYQ--EPHPQPWAQT
.| ..|   ||.......  .|..|.|| |..| ..| ..              |||  .    .   .           | ||  |.  ... . ... 
eeflewlrslPlaavigg.kilfvHGGlspdlplldqireierpleipddgllldllwsd.P..weddgdgllrlrffgnsprgagylFgpdaveeflkk

WiGPDHVYFGHDAIRF---LQRYPFATGLDTGC--------VY-GGHLTAVFDDEREKlIQVKAAKAYEQPKK
. | |.. .|| . .    |.. . ..|.|||.        .. ||.|.||   . .. |...  .....|..
n.gldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpli
0049330 Metallo-dependent phosphatases 54-278 4.6e-35 114.4 In-house 57-272 (309) alignment 
Range on Protein: 54-278
Range on HMM: 57-272/309.0
RRLLVVGDVHGCYDELVQLLDKAGGRDPgVLVVFVGDVCNKGPLNVESIRLVREV------GGYCVRGNHDEICLLEWLKhseGAEPLSDKFSwlSRLSK
.|. |.||.||..|.| .||.|.|  ..  ..||.||....|| ..| ..|...       . ...||||.   |  ...   . . .  |..  ..| .
mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrllnglyg...fgdetlrkyg..aelwe

EEMDWYFELPFSIHFPSrEVLVIHAGLVPGVPIEEQSHH--------------DLLH-----LRNVtfdlrtltfsserggayqephpqpWAQTWIGPDh
| .||.  ||. ..... ..|..|.|| |... ..| ..              |||.      |.                         .|. . | . 
efldwlrslplaavigg.kilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpireg........................fapnprglg.

VYFGHDAI-RFLQRYPF-ATGLDTGCVYGGHLTaVFDderEKLIQVKAAKAY
|.|||.|. |||... .     ..|.|.||.||  ||   .|||.|  |  |
vvfghtaverflkkngldliirghgavfgGylt.ffd...gklitvfsapny
0053225 Metallo-dependent phosphatases 54-277 3.7e-33 108.4 In-house 49-263 (293) alignment 
Range on Protein: 54-277
Range on HMM: 49-263/293.0
RRLLVVGDVHGCYDELVQLLDKAGGRDPgVLVVFVGDVCNKGPLNVESIRLVREV------GGYCVRGNHDEICLLEWLKhsegaE---PLSDKFswLSR
 |..|.||.||..|.| .||.|.|  ..  ..||.||....|| ..| ..|...       . ...||||..  |  ..           |   .   ..
mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmllnglyg.....fgdetlrkyg..aae

LSKEEMDWYFELPFSIHFPSrEVLVIHAGLVPGVPIEEQSHHDLLHLRNVTFDLRTLTFSSERggayqePHPQPWAQTWIGPDhVYFGHDAI-RFLQRYP
| .| .||.  ||....... ..|..|.|| |... ..| .. . .||  ...| .    |.       ..  .|.. . |   |.|||.|. |||... 
lwdelldwlrslplaaligg.kilfvHgGlspdlslldqireinrplriplegllldllwsdp......dlwsgwlpsyrglg.vvfghtavlrflkkng

fATGLDTG--CVYGGHLTaVFDderEKLIQVKAAKA
  . ...|  .|..|.|.  ||   .||..|  | .
.ldliirghqvvpdgylp.wfd...gklvtvfsapn
subfamily_PPP7C_pd Subfamily PPP7C 54-174 4e-06 18.8 In-house 64-187 (383) alignment 
Range on Protein: 54-174
Range on HMM: 64-187/383.0
RRLLVVGDVHGCYDELVQLLDKAGGRDPGVLVVFVGDVCNKGPLNVES------IRLVREVGGYCVRGNHDEICLLewLKHSEGAEpLSDKF-SWLSRLS
... | ||.||  |.|. .| | |   .    || ||  ..|   ||       . ||     |  ||||..  |   |..    | ...|. .  ... 
kevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhiln..lryGfike.veskykvhgkkil

KEEMDWYFELPFSIHFpSREVLVIHAGL
.   | .  ||..     ...|..| |.
rlledvfawlplatli.dekilivhGGi
Metallophos Calcineurin-like phosphoesterase 55-182 9.8e-13 41.8 Pfam-A 2-168 (200) alignment 
Range on Protein: 55-182
Range on HMM: 2-168/200.0
RLLVVGDVHGCYDEL---VQLLDKAGGRDPGVLVVFVGDVCNKGPLNVESIR--------LVREVGGYCVRGNHDEICLLEWLKHSEGAE----------
| ||.||.||..|.|   . .|.|.... .  ||.| ||. . |.   | ..        | . .  ...||||.  .. . ... .             
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------PLSDKFSWLSRLSKEEMDWYFELPFSIHFPSREVLVIHAGLVPGVPIEE
                   ||..   |     ||  . |...   .     .|..|..| .    ..
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgd
PP2Ac_SM00156 55-181 7.9e-10 31.2 In-house 29-150 (271) alignment 
Range on Protein: 55-181
Range on HMM: 29-150/271.0
RLLVVGDVHGCYDELVQLLDKAGgRDPGVLVVFVGDVCNKGPLNVESIRLVREV------GGYCVRGNHDEICLLewlKHSEGAEPLSDKFswLSRLSKE
 . ||||.|| .| |..||..|| . |   .|| ||  ..|| ..| | |. ..        .  |||| .  .    |.    | .. |    ... ..
pvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn...kiygfeeevkrky..gkeiyek

EMDWYFELPFSIHFpSREVLVIHAGLVPgvpiE
 .. .  ||..    ....|..| || |    |
feeafsllPlaalv.dskilcmhGGlsp....e
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 55-176 3.1e-09 29.0 Pfam-A 2-93 (156) alignment 
Range on Protein: 55-176
Range on HMM: 2-93/156.0
RLLVVGDVHGCYDELVQLLDKAggRDpGVLVVFVGDVCNkgplNVESIRLVREVGGYCVRGNHDeicllewlkhsegaeplS----------Dkfswlsr
......|.||  |.| ..|...  ..   |....||...      | ..|....  . ||||||                                    
kiaiiSDlHgnldaleavledi..ke.vdlilhaGDlve....peevvelledipvlavrGnhD.................eaelpkelavel.......

lskeemdwyFELPFSIHFPSREVLVIHAGLVP
         ..  . ...  ..||..|   ..
.........llaaaaleiegdrvllvhgtpls
PPP_3 55-183 3.8e-09 29.0 In-house 30-158 (271) alignment 
Range on Protein: 55-183
Range on HMM: 30-158/271.0
RLLVVGDVHGCYDELvQLLDKAGGRDPGVLVVFVGDVCNKGPLNVESIRLVRE------VGGYCVRGNHDEICLLEWLKHSEGAEplsDKFSwLSRLSKE
.. |.||.|| .| |   | | ||. |    .| ||  ..|   .| . |.           . .||||..  . .     .       |    ... |.
pvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkvYgFkkevl...kkkg.gkkvykk

EMDWYFELPFSIHFpSREVLVIHAGLVPGVPIEEQ
 .. .  || .    ...|||.| || | .  ..|
lqevFelLplaali.dekvlvvHGGlspsiksldq
PPP_1 56-186 2.9e-08 26.3 In-house 30-160 (264) alignment 
Range on Protein: 56-186
Range on HMM: 30-160/264.0
LLVVGDVHGCYDELvQLLDKAGGRDPGVLVVFVGDVCNKGPLNVESIRLVR------EVGGYCVRGNHDEICLLEWLKHSEGAEplsdKFSWLSRLSKEE
. |.||.|| .|.|   | |.||  |    .|.||   .|   || . |.       .   . .||||.   . .     .       |    ... |  
itvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvygFkkEvl....kkkyskeiyktl

MDWYFELPFSIHFpSREVLVIHAGLVPGVPIEEQSHH
.| .  || .      ..|..| || | .  ..| ..
tdvFdvLplaali.dekilivHGGlspeldlldqirk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 56-119 6.6e-08 25.1 In-house 53-121 (299) alignment 
Range on Protein: 56-119
Range on HMM: 53-121/299.0
LLVVGDVHGCYDELVQLLDKAGgRDPGVLVVFVGDVCNKGPLNVESIRLVRE------VGGYCVRGNHDE
. |.||.|| | .|....||||   | |  .|.||  ..|  |.| | |.           . .||||. 
iivcgdihgqysdllrifdkag.fppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 56-176 7.8e-08 24.6 In-house 39-158 (287) alignment 
Range on Protein: 56-176
Range on HMM: 39-158/287.0
LLVVGDVHGCYDELVQLLDKAgGRDPGVLVVFVGDVCNKGPLNVESIR------LVREVGGYCVRGNHDEICLLewlKHSEGAEPLSDKFSwlSRLSKEE
. .|||.|| .|.|......  |. | |  .|.||  ..|.  .| .       .      . .||||.   .    |     | |  |..  .|| |. 
itivGdihGqlddllrifnav.GaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkin...klyGfkeelkrkrq..erlykqf

MDWYFELPFSIHFpSREVLVIHAGLVP
 | . |||.  .  |. .| .| |. |
ndvfselplcarv.skrilcmhGGisp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 56-118 2.8e-07 22.9 In-house 45-112 (290) alignment 
Range on Protein: 56-118
Range on HMM: 45-112/290.0
LLVVGDVHGCYDELVQLLDKAgGRDPGVLVVFVGDVCNKGPLNVESIRL------VREVGGYCVRGNHD
. .|||.||  |.|.. .|.  |. | |  .|.||  ..|.  .|   |            . .||||.
ivivgdihgqldallryfdav.gyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe
subfamily_PPP2C_pd Subfamily PPP2C 56-105 7e-07 21.7 In-house 46-94 (290) alignment 
Range on Protein: 56-105
Range on HMM: 46-94/290.0
LLVVGDVHGCYDELVQLLdKAGGRDPGVLVVFVGDVCNKGPLNVESIRLV
. |.||||| . .|..|. | ||. |    .|.||  ..|   ||.. |.
vtvcgdvhgqfhdllelf.kiggkspdtnylflgdyvdrgyysvetvtll
subfamily_PPP1C_pd Subfamily PPP1C 56-121 8.8e-07 21.4 In-house 39-109 (282) alignment 
Range on Protein: 56-121
Range on HMM: 39-109/282.0
LLVVGDVHGCYDELVQLLDKAgGRDPGVLVVFVGDVCNKGPLNVESIRLVRE------VGGYCVRGNHDEIC
. .|||.|| | .|..|.... |  |    .|.||  ..|   .| | |.           . .||||..  
vkivgdihGqyadllrlfets.gaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesas
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 56-120 1.4e-06 20.6 In-house 35-104 (280) alignment 
Range on Protein: 56-120
Range on HMM: 35-104/280.0
LLVVGDVHGCYDELVQLLDKAgGRDPGVLVVFVGDVCNKGPLNVESIRLVR-----EVGG-YCVRGNHDEI
. |.||.|| | .|..|.... .  |    .|.||  ..|  ..| | |.         . . .||||. |
vavcgdlhgqytdllrlfarv.sfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevi
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 56-118 2.1e-06 20.2 In-house 52-119 (297) alignment 
Range on Protein: 56-118
Range on HMM: 52-119/297.0
LLVVGDVHGCYDELVQLLDKaGGRDPGVLVVFVGDVCNKGPLNVESIRLVRE--V----GGYCVRGNHD
. |.||.|| . .|..|. . ||  |    .|.||  ..| . .|.| |.    |      . .||||.
ikvcgdihgqfpdllrlfhr.ggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhe
PPP_5_Dcr2 57-237 2.3e-13 43.6 In-house 2-181 (199) alignment 
Range on Protein: 57-237
Range on HMM: 2-181/199.0
LVVGDVHGCYDEL-VQLLdKAGGRDP-GVLVVFVGDVCNKGPLNVESIRLVREV------GGYCVRGNHDEICLLEWLKHSEGAEplsDKFSwLSRLSKE
 |.||.|| .|.| ..|. | ||. .   |.||.||.  .|. ..| . |. ..        ...||||..  | |     .      .|.   ... | 
tvcGDlHGqlddlllilf.keggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevl...skyh.gkkiyki

EMDWYFELPFsIHFPSREVLVIHAGLVPGVPiEEQSHHDLLHLRNVtfdlrTLTFSSERGGA-YQEPH--PQP-WAQTWIGPDHvYFGHDAIR
  | . .||   .. ...|||.| || | .  . .. ... . ...     . .   ..    ...|    .  ....  | .. .||.|...
lsdvfdwlPl.aalidekvlvvhgglspeik.siellekierkiei.....peekgekadlllwsdprdaqegcklnseRGagl.lfgpdvte
PPP_4 57-240 7e-13 42.1 In-house 2-183 (197) alignment 
Range on Protein: 57-240
Range on HMM: 2-183/197.0
LVVGDVHG-CYDELVQLLDkAGGRD-PGVLVVFVGDVCNKGPLNVESIRLVREV------GGYCVRGNHDEICLLEWLKHSEGAEplsDKfsWLSRLSKE
 ||||.|| ..| |..||.  ||.  .   .||.||.  .|. ..| . |. ..        ...|||| .  | .  .  .      .|    ... |.
tvvGDiHGqlddlllkllk.ngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevl...ek..hgkeilkk

EMDWYFELPFSiHFPSREVLVIHAGLVPGVPiEEQSHHDLLHLRNVtfdlR-------TLT-FSSERggayqePHPQPWAQTWIGPDHvYFGHDAIR-FL
 .| .  || . .. ...|||.| || . .  . ...... . ...    .       .|  .| .|      .. . .|..  | .. .||.|... ||
lqdvfdllpla.alidekvlvvhgglsdele.sldkierierkies....pleeekrkdlllwsdpr......eaqeglansvrGagl.lFgpdvtekfl

Q
.
e
PPP_2 57-188 2.7e-09 30.0 In-house 2-133 (198) alignment 
Range on Protein: 57-188
Range on HMM: 2-133/198.0
LVVGDVHGCYDELvQLLDKAGGRDPGVLVVFVGDVCNKGPLNVESIRLVR------EVGGYCVRGNHDEICLLEWLKHSEGAEplsDKFSwLSRLSKEEM
 |.||.|| .| |   | | |.. |    .|.||  ..|  ..| . |.           . .||||..  . .     .       |    ... |. .
tvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl...kkkg.gkkvykklq

DWYFELPFSIHFpSREVLVIHAGLVPGVPIEEQSHHDL
. .  || .    ...|||.| || . .  ..| ... 
evfelLplaali.dekvlvvHGGlseeiklldqikkee
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 57-118 4.4e-07 22.2 In-house 54-120 (298) alignment 
Range on Protein: 57-118
Range on HMM: 54-120/298.0
LVVGDVHGCYDELVQLLDKaGGRDPGVLVVFVGDVCNKGPLNVESIRLVRE------VGGYCVRGNHD
 | ||.|| | .|..|.|| .|  | .  .|.||  ..|  |.| | |.           . .||||.
kvcGdihGqysdllrlfdk.agfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhe
subfamily_PPP3C_pd Subfamily PPP3C 57-177 8.3e-07 21.1 In-house 71-190 (452) alignment 
Range on Protein: 57-177
Range on HMM: 71-190/452.0
LVVGDVHGCYDELVQLLDkAGGRDPGVLVVFVGDVCNKGPLNVESI------RLVREVGGYCVRGNHDEICLLEWLKHSEGaepLSDKFSwlSRLSKEEM
 |.||.|| . .|..|..  ||       .|.||  ..|   .| .      ..  .   . .||||.  .| |...  |    .  |.|   .. .. |
tviGdihGqfydllklfe.vgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkee...ckikys..eevydacm

DWYFELPFSIHFpSREVLVIHAGLVPG
. .  ||..  .  .. | .| || | 
esfdslPlaall.nqqflcvhGGlspe
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 57-118 2.9e-06 19.7 In-house 38-104 (281) alignment 
Range on Protein: 57-118
Range on HMM: 38-104/281.0
LVVGDVHGCYDELVQLLDKAgGRDPGVLVVFVGDVCNKGPLNVESIRLVREV------GGYCVRGNHD
 ||||.|. ...| .|..   || |   .||.||  ..|| ..| . |.  .        . .||||.
vvvGdlhaqfndlkrlfell.grvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe
subfamily_PPG1_pd Subfamily PPG1 57-105 5.5e-06 18.8 In-house 44-91 (300) alignment 
Range on Protein: 57-105
Range on HMM: 44-91/300.0
LVVGDVHGCYDELVQLLdKAGGRDPGVLVVFVGDVCNKGPLNVESIRLV
 ||||||| . ...... | ||. |    .|.||  ..|   ||.| |.
tvvgdvhgqfydvleif.kiggqvpdtnylflgdyvdrglysvetisll
subfamily_PPZ_pd Subfamily PPZ 57-105 5.6e-06 19.1 In-house 55-102 (300) alignment 
Range on Protein: 57-105
Range on HMM: 55-102/300.0
LVVGDVHGCYDELVQLLDKAGgRDPGVLVVFVGDVCNKGPLNVESIRLV
 .|||||| | .|..|. |.|   |    .|.||  ..|  ..|.| |.
kivgdvhgqyadllrlftkcg.fppsanylflgdyvdrgkqsletilll
subfamily_PPP4C_pd Subfamily PPP4C 57-105 7.1e-06 18.4 In-house 46-93 (288) alignment 
Range on Protein: 57-105
Range on HMM: 46-93/288.0
LVVGDVHGCYDELVQLLDKaGGRDPGVLVVFVGDVCNKGPLNVESIRLV
 | ||.|| . .|..|..  ||  |    .|.||  ..|   ||.. |.
tvcgdihgqfydllelfkv.ggdvpetnylflgdfvdrgfysvetflll