Gene ILKAP-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily ILKAP
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP202_AA protein Get Run
AqueP202_AA_62-362 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 63-362 1.8e-54 177.6 In-house 14-290 (295) alignment 
Range on Protein: 63-362
Range on HMM: 14-290/295.0
VTLSRYQLRGYHGERKGEREEMQDSHVIINNMMEQFPTlsnspvssVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPK----EDVSAQSIKRCLVDSFK
.... ..|| ..   .| |....|..... |.. ...         ....||||||.|..|.|.|. .|.. ... . |     . |  .|...|...|.
lsslllllrvgvasdqGrrksneDavlvvlnllslled........lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkafl

KTDSDFLSLAAKATPSWKDGSTVAIIMAIDNVLYSGNLGDSKSVIYRRSgkgdtggeptvVSVPLTKDHTSA-----IGGKEEDRKIWEGRIMGIMEVSR
..| ..|.|| .    .  |.|. ... ..| || .|.|||. |..|.            . |.||.||. .      . ....  .  ||..|.. |.|
aadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrng...........elvqltvdhkpvnelererilsaggavshgrvngvlavtR

SIGDGRFK--------GCGLVATPHVSRCELT-ENDLFVVVACDGLWNVFKMDEVAKFILGVV----NdesiqkpgeddrliqgtevigdreyrFEVACN
..|| ..|        . ...|.|.|.  ||| |.| |...|.||||.|.  .|.....  ..    .                           |.|..
alGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld..........................leeaae

RLAVEAVKRGCTDNVTVLIVDI
.|. .|..||..||.||..|..
eLvdlAlargsrDNiTvvvvrl
subfamily_ILKAP_pd Subfamily ILKAP 67-362 2.3e-139 456.5 In-house 2-292 (293) alignment 
Range on Protein: 67-362
Range on HMM: 2-292/293.0
RYQLRGYHGERKGEREEMQDSHVIINNMMEQfPTLSNSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSA--QSIKRCLVDSFKKTDSDF
.|.|.|...|||||||||||.|||.....|| ..|..|.||.||||.|||||.||||||||| .||..|..|.||.||||  ..||.||||||||||..|
lyklkgayaerkGereemqdahviledldeq.lrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeef

LSLAAKATPSWKDGSTVAIIMAIDNVLYSGNLGDSKSVIYRRSGKGDTggeptVVSVPLTKDHTSAiggKEEDRK--------IWEGRIMGIMEVSRSIG
|.||.||.|.||||||.......|||||..||||||.|..|.. .||.     ..||.||||||..   |.|.||        ...||..|..|||||||
LklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdk.....iasvvLtkdhtpv...kyeerkriqkaGgvvrdgrvlGvlevsrsiG

DGRFKGCGLVATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDEsiqkpgEDDRLIQGTEVIGDREYRFEVACNRLAVEAVKRGCTDNVT
|||||..|...||.|..|||||||||||.||||||.||..|||.|||| |..||      |||| |...|.. ..|.||||||||||.||||||..||||
dgrfkrlGvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvlede......eddrkikeeekkskeevrfevacnrlaseavkrgssdnvt

VLIVDI
||.|.|
vllvki
PP2Cc_SM00332 72-360 3.1e-47 154.2 In-house 10-274 (274) alignment 
Range on Protein: 72-360
Range on HMM: 10-274/274.0
GYHGE--RKGEREEMQDSHVIINNMMeqfptlsnsPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDV-SAQSIKRCLVDSFKKTDSDFLSLA
  .|    .|.|..|.| ||.....          . ......||||||.||....|.. .|.. . ..  |..  . ......| ..|..||...|  .
lsygkssmqgwrksmeDahvvvvdlv.........eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileee

AKATP-SWKDGSTVAIIMAIDNVLYSGNLGDSKSVIYRRSGkgdtggeptvvSVPLTKDHTS-----AIGGKEEDRKIWEGRIMGIMEVSRSIGDGRFK-
 .  .  .. |||. ...  .. ||  |.|||. |..| .            .|.|..||.          |..  ..  ||. |  .|||..||. .| 
qskelenalsGstavvallkkedlyvanvGDSravlcrngk...........avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkk

-----GCGLVATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDEsiqkpgeddrliqgtevigdREYRFEVACNRLAVEAVKR-GCTDNV
       ...|.|.|. ..||..| |...|.||||.|.. .|| ...    . .                     . . . |...|. || .| |..||.
nkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg....................ktndpqeaaelldeeairrggseDni

TVLIV
||..|
Tvvvv
0049733 PP2C-like 76-361 1.4e-42 138.7 In-house 9-232 (235) alignment 
Range on Protein: 76-361
Range on HMM: 9-232/235.0
ERKGE-REEMQDSHVIinnmmeqfptlsnspvsSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKedVSAQSIKRCLVDSFKKTDSDFLSLAAKATPS
 ..|  |....|....                 ......|.|||.|..|.|.|...|...... . .   .  .....|...|..... .|.|| .  . 
sdigrvrkvneDavlv.................glllfavaDGhgghaagevasellvetllellle..lllldleealrkaflaaneallelalaspel

WKDGSTVAIIMAIDNVLYSGNLGDSKSVIYRrSGKgdtggeptvvSVPLTKDHTSAIGGK----------EedrkiwegRIMGIMEVSRSIGDGRFKgcg
.  |.|..... ... ||  |.|||  ...| .||           |.||.||. .                       |..|.  ..|..||  .|   
agmgtTavvalldggklyvanvGDsrayllr.dgk..........lvqltedhspvnelerqriitaggav........rvpgrlaltralGdlllk...

lvatPHVSRCELTENDlFVVVACDGLWNVFKMDEVAKFILGvvNDEsiqkpgeddrliqgtevigdreyrfEVACNRLAVEAVKRGCTDNVTVLIVD
    |.|...||...| |...|.||||.|.  .|..... .  .|                          | |..||. .|..|| .||.||..|.
....pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs..ldl.........................eeaaerlvelalarggrDNiTvvvvr
PP2C Protein phosphatase 2C 76-355 1e-40 132.9 Pfam-A 7-255 (255) alignment 
Range on Protein: 76-355
Range on HMM: 7-255/255.0
ERKGEREEMQDSHVIINNMMEQfptlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSaqSIKRCLVDSFKK-TDSDFLSLAAKAtPS
| .| |..| |.|....|....      |. |||....||||| |..|...|. .|. .. ..  ...      ...| .|| . ||. . | .|..   
elqgarksmedahialknleks......sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfladtdeelksskant.ep

WKDGSTVAIIMAIDNVLYSGNLGDSKSVIYRRSGKGdtggeptvvsVPLTKDHTSAI----------GGKEEDrkiwEGRIMGIMEVSRSIGDGRFKG--
.| |||  ...  .. ||  |.|||. |. |...            . ||.||. .           ||. ..    .||. | ..|||..|| ..|   
sksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsn....ngrvngsLavsRalGdfelkpke

-CGLVATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESiqkpgeddrliqgtevigdreyRFEVACNRLAVEAVKRGCTDNV
 .  .| |.|.  .|||.| |...|.||||.|.. .|.. ..   .....                        . |...|. ||..||..||.
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......................spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 76-355 1e-40 132.9 In-house 7-255 (255) alignment 
Range on Protein: 76-355
Range on HMM: 7-255/255.0
ERKGEREEMQDSHVIINNMMEQfptlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSaqSIKRCLVDSFKK-TDSDFLSLAAKAtPS
| .| |..| |.|....|....      |. |||....||||| |..|...|. .|. .. ..  ...      ...| .|| . ||. . | .|..   
elqgarksmedahialknleks......sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfladtdeelksskant.ep

WKDGSTVAIIMAIDNVLYSGNLGDSKSVIYRRSGKGdtggeptvvsVPLTKDHTSAI----------GGKEEDrkiwEGRIMGIMEVSRSIGDGRFKG--
.| |||  ...  .. ||  |.|||. |. |...            . ||.||. .           ||. ..    .||. | ..|||..|| ..|   
sksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsn....ngrvngsLavsRalGdfelkpke

-CGLVATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESiqkpgeddrliqgtevigdreyRFEVACNRLAVEAVKRGCTDNV
 .  .| |.|.  .|||.| |...|.||||.|.. .|.. ..   .....                        . |...|. ||..||..||.
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......................spmeaaeelvdeaiargsedni
subfamily_PPM1A_pd Subfamily PPM1A 76-361 5.3e-38 124.0 In-house 18-279 (282) alignment 
Range on Protein: 76-361
Range on HMM: 18-279/282.0
ERKGEREEMQDSHVIINNMMeQfptLsnspvSSVSYYGVFDGHSGSRASEFAAGNLHRVIVN--KF---PKEDVSAQSIKRCLVDSFKKTDSDFLSLAAK
. .| | || |.|... ..  .   |     .. |.. |||||.||....... .|.. |..  ..    .|. .....|  | ..| ..|..  .| ..
smqgwrvemEDahtvvaslg.a...l.....kdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd

ATPSWKDGSTVAIIMAIDNVLYSGNLGDSKSVIYRRSgKGDTGGEPTVVSVPLTKDHTSAIGGkeedrKIWEGRIMGIMEVSRSIGDGRFKG--------
.. . | |||.  ..  .. |.  |||||..|..|   |     |    | |  |.  .. ||     ..  .|..| . |||..||  .|         
lktadksGsTavtvlvsekhliianlGDsRavlcrng.kaaflteDHkpsrpkEkkRieqAGG.....svvvsRvnGaLAvsRalGDyeykeeeekkaee

CGLVATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDE-S---IqkpgeddrliqgtevigdreyrfevaCNRLAVEAVKRGCTDNVTVL
  ..| |.|  .| .|.| |.|.||||.| | . .||....   ..       .                          ...|  .| ..| .||..||
qlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev..........................akalvdkalekgsrDNlsvl

IVD
.| 
vvl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 76-310 1.6e-27 89.4 In-house 12-227 (255) alignment 
Range on Protein: 76-310
Range on HMM: 12-227/255.0
ERKGEREEMQDSHVIINNMMEQfptlSNSpvssvSYYGVFDGHSGSRASEFAAGNLHRVIVNKFpkeDVSAQSIKRCLVDSFKKTDSDFlslaaKATPsW
.  | |  |.|. ||  .  ..    |..      || .||||.|..|..||. .|.... ...   |.   . ...| ...|...  .     .  |  
dmiGrrptmedelviyGsfrdk....sde.....dyyalfdGhgGraaakfaseelykilaell...dlnnanPvkslkkaykeistqi.....serp.k

KDGSTVAIIMAIDNVLYSGNLGDSKSVIYRRSGKGDTGGEPTVVSVPLTKDHTSAIGGKEEDRkIWEGRIMGIMEVSRSIGDGrFKGCGLVATPHVS-RC
  |.| | .. |..  |  |.|||. |. .. |  .        | .  .   |..||.         |. | . |||..||  |    .|. |..|   
fiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvst.vvtsrvnGtlavsralGds.flePfvvpdPdlsqsl

ELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDE
| ...| |...||||.|..   .|  . ..|. . |
eiskkdkflilacdGiwdlisdeeaveivagisdpe
subfamily_PPM1D_pd Subfamily PPM1D 77-251 1.3e-16 53.5 In-house 9-177 (309) alignment 
Range on Protein: 77-251
Range on HMM: 9-177/309.0
RKGEREEMQDSHVIINNMMEQFPtlsnspVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAQSIKRCLVDSFKKTDSDFLSLAAKATPSW-
..|.|. |.|  .|  .  |.          .|.. .||||| |  |..||  .|  || ..      . ... . . ..| .| .      .. ..   
dqGgrkymeDvvaivleeeesae......elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktks

----KDGSTVAIIMAIDNVLYSGNLGDSKSVIYRRSGkgdtgGEPTVVSVPLTKDHTSAIGGKEEDRKIWEGRIMGIMEV
      |.|.....  .. || .. |||. |.  .       .|..... .|||||   .   .|  .   |...    |
gllstaGttasvviirreklyvahvGDsaivlgvkep.....kekklrakeltkdHkPespeekerieelGGevaaksGv
subfamily_PPM1G_pd Subfamily PPM1G 77-164 1.5e-07 23.7 In-house 26-99 (473) alignment 
Range on Protein: 77-164
Range on HMM: 26-99/473.0
RKGEREEMQDSHVIINNMMEQfptlsnspvssVSYYGVFDGHSGSRASEFAAGNLHRVIVNKfpkEDVSAQSIKRCLVDSFKKTDSDF
 .| |... |.|  | .. |.           .| ..|.||| |.  ... | .|  .. ..   .   .  ....| ..| . |.  
mqGwrvsqEDahncitdlded...........tslfavyDGHGGkevakyvakklpdllkaq...kgykegdvekaleeaflalDekl
PPM_PTC7 78-355 1.1e-38 126.2 In-house 9-259 (259) alignment 
Range on Protein: 78-355
Range on HMM: 9-259/259.0
KGEREEMQDSHVIINNMMEQfptlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSaqSIKRCLVDSFKK--TDSDFLSLAAKAtPSW
.| |..| |.|.. .|.. .      |. .||....||||| |..|...|. .|. .. ..  .|.      ...| .|| .  ||. . | .|..  ..
qgfrksmedahialanless......sgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelksseant.eps

KDGSTVAIIMAIDNVLYSGNLGDSKSVIYRRSGKGDTGGEPTVVSVPLTKDHTSAIGGKEEDRkiWEGRIMGIMEVSRSIGDGRFKG-----CGLVATPH
. |||  ... ... ||  |.|||. |. |. .   .  |   .| .  ..  .. ||. ..    .||. |  .|||..|| ..|      . ..|.|.
tsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnv..gngrvngvlavsRafGdfelkpketeeqlvsaePd

VSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDEsiqkpgeddrliqgtevigdreyRFEVACNRLAVEAVKRGCTDNV
.|  ...|.| |...|.||||.|.  .|.. ..  .....                         . |...|. ||..||..||.
isstkideedefliLasdGlwdvvsdqeavdlvrselskk.......................dpmeaaeklvdeaiargsedni
subfamily_PPM1E_pd Subfamily PPM1E 78-314 2.7e-36 118.1 In-house 12-235 (265) alignment 
Range on Protein: 78-314
Range on HMM: 12-235/265.0
KGEREEMQDSHVIINNMMEQFPTlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAqsikRCLVDSFKKTDSDFLSLAAKAtpSWKD
|..|  | | ||..... | |     .  .  ....|||||.|. |...|| .||...|..   .. .|    . | ..||.||. ||. |..   ..| 
knkrrkmEDrhvaledlnelfel...kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa....ealkeafkltDerflqkaere..klks

GSTVAIIMAIDNVLYSGNLGDSKSVIYRRsGKGDTGGEPTVVSVPLTKDHTSAIGGKEEDRKIWegRIMGIMEVSRSIGDGRFKGCgLVATPHVSRCELT
|||  ...   . || . ||||.... |  |.  .  .|   . .  |.   . ||       |  |. |.. |||.||| . |   ... . |...||.
GstavvvliekdqlyvaWlGDsqallvrk.geavqlmkpHkPeredEkkRieeagGlvvvigaw..RvnGvLsvsRaiGDvklkpy.vsgeadvaeveld

ENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQK
... ....||||||.|.. .|| | .   ..|.. ..
gseeylilacDGlwDvvneeevvklveefladgaedl
subfamily_PPM1G2_pd Subfamily PPM1G2 78-305 3.2e-32 104.6 In-house 27-245 (287) alignment 
Range on Protein: 78-305
Range on HMM: 27-245/287.0
KGEREEMQDSHVIINNmmeqfpTLSNSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNkfpKEDVSAQSIKRCLVDSFKKTDSDFLSLaaKATPSWKD
.| | .| |.|.. |.       |..|  .|.....||||| |......|. .|...|..   |.. . ......| |.|..||...|.   ...   . 
qGyrlnmeDahilene......lleksddkslalfavfDGhGGakvakyagkklikkiak...kksfkegaleqilkdafletDeellkd..eklkdesa

GSTVAIIMAIDNVLYSGNLGDSKSVIYRRSGkGDTGgepTVVSVPLTKDHTSAIggKEEDRKIWEGRIMGIMEVSRSIGDGRFKGCG--------LVATP
|||  ... ... || .| |||..|.  ..   ..    ..   | ... .. |  .. .  .  .|. | . .||..||  || .           |.|
GstavvvlikeeklyvanaGDsravlsskgn.vkal...sfDhkPqeesekkri..iaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavP

HVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILG
 |   .|.|.| |.|.||||.|.|.. .|| ...  
DvlvkkldeddeflvLaCDGiWDvltnkevvdlvre
PPM_PTC7_SpoIIE 78-319 3.8e-18 59.1 In-house 9-221 (230) alignment 
Range on Protein: 78-319
Range on HMM: 9-221/230.0
KGEREEMQDSHVIINNMMEQfptlsnSPVSSVSYYGVFDGHSGSRasEFAAGNLHRVIVNKFpKEDVSaqSIKRCLVDSFKKTDSDF--LslaakatpSW
.| |..| |.|.. .|..        |. ... ..|..||| |.    .|.| |. .. .   ... .    . .| ... . . |.            .
qgarksmedahispanseks......sggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..kpeeilrrlnlalaadlede........ps

KDGSTVAIIMAIDNV--LYSGNLGDSKSVIYRRSGKgdtggeptvVSVPLtKDHTSA-IGGKEEdrkiwegRIMGIMEVSRSIGDGRFKG-CGLV-ATPH
. |.|. ..    .   ||  |.|||  ...| .|.         .  .. . .  . .|  ..       |. |  .||...||  ..   |.| | |.
ssgaTavvalidpstgklyvanaGdsppllvrddgg.........ereri.vagglpslGilpg.......rvfgvlavslapGdllllytDGvveaepd

VSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQKPGEDD
 |. || ..| |...|.||||.|   .|.. ...  ...   .. .|||
tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekpaaeglleDD
subfamily_PPM1L_pd Subfamily PPM1L 79-307 9.9e-23 73.7 In-house 14-236 (269) alignment 
Range on Protein: 79-307
Range on HMM: 14-236/269.0
GEREEMQDSHVIINNMMEQfptlsnspvSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKF-----PKEDVSAQSIKRCLVDSFKKTDSDFLSLAAKATP
| |..|.|   | ... ..          . |...||||| |  |.|||   | . | ||.      ||.    . .. |.|     | ..|  | .|. 
Grrprmedrfeieediknk.........tgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraed

swKDGSTVAIIMAIDNVLYSGNLGDSKSVIYRRSGKGDTGGEPTVVSVPLTKDHTSAIGGKEEDRKIWegRIMGIMEVSRSIGDGRFKGCGLV-ATPHVS
    |.|. | .  .. |   |.|||. |.| ..||            .  .      ||    | .|  |. |.. .||..||  .|   || |.| . 
..iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvw..rvaGvlatsralGdyplkdknlviadpdil

RCELTEN-DLFVVVACDGLWNVFKMDEVAKFILGVV
  .| .    |...|.||||. |  .|  .||.  .
tfdlddhkpeflilasdGlwdtfsneeavrfikerl
subfamily_KAPP-like_pd Subfamily KAPP-like 83-299 2.9e-18 58.9 In-house 11-224 (266) alignment 
Range on Protein: 83-299
Range on HMM: 11-224/266.0
EMQDSHVIINNMMEQfPTLSNspVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPK---EDV--SAQSIKRCLVDSFKKTDSDF-----LSLAAKAT
||.| .. |  ....   |||  .| .. ..|||||.|  |.. |   . ... ..  .   .|   .    .. | ..||. |. .        .|  .
emedvslaiypllke.kklsn..csnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatla

PSWKDGstvaiimaIDNVLYSGNLGDSKSVIYRrsgkgdtGGEptvvSVPLTKDHTSAigGKEEDRKI-------WE--GRIMGIMeVSRSIGDGRFK--
  |.||            | ..|.||| . . |       | |    |. |.||| .    .|| ..|        .   || |.. |||..||   |  
lvwsdG........qqrylqvanvGdssaflsr.......Gne....slelskdhkak..dpeekqrikddGitlsdnqtrinGla.vsralGdhfikel

GCGLVATPHVS-RCELTENDLFVVVACDGLWNVFKMDEV
 .||...|.|| |  ||  | |..|| ||||.| . .. 
niGlisepyvsnrilltpfdkflivasdGlwdvisGkda
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 83-299 9e-16 50.5 In-house 10-234 (276) alignment 
Range on Protein: 83-299
Range on HMM: 10-234/276.0
EMQDSHVIINNMMEQfPTLSNspVSSVSYYGVFDGHSGSRASEfAAGNLHRVIVNKFPKE--------DVS---AQSIKRCLVDSFKKTDSD---FLSLA
||.| .. |  ....   |||  .| .. ..|||||.|  |.. || .|   ...|. |         |         .. | | ||. |.    |    
emedvslaiypllde.kdlsn..csnialfavfdGhaGkGaad.aakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeG

AKAT--PSWKDGSTVAiiMAIDNVLYSGNLGDSKSVIYRrsgkgdtGGEptvvSVPLTKDHTSAiGGKEE------DRKIWE--GRIMGIMeVSRSIGDG
| ||    |.||         .  | ..|.||| . . |       | |    |. |.||| ..   .|          . .   || |.. |||..|| 
atatlalvwsdGeeqq..qqqqrylqvanvGdssaflsr.......Gne....slelskdhkat.dpeekqrikddGitlsdnqtrinGla.vsralGdh

RFK--GCGLVATPHVS-RCELTENDLFVVVACDGLWNVFKMDEV
  |   .||...|.|| |  ||  | |..|| ||||.| . .. 
fikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkda
subfamily_PP2D1_pd Subfamily PP2D1 84-147 7.8e-07 21.1 In-house 17-71 (492) alignment 
Range on Protein: 84-147
Range on HMM: 17-71/492.0
MQDSHVIINNMMEQfptlsnspvSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAQ
|.| ... .. ...           ....|..||. |. | | || .||.|....  | | . .
meDkrtlqdyfgnd.........vnscFfgiyDGynGataAeiaakelhevlleelekvdervs
subfamily_PPM1H_pd Subfamily PPM1H 100-139 9.4e-07 20.9 In-house 53-92 (404) alignment 
Range on Protein: 100-139
Range on HMM: 53-92/404.0
TLSNSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKF
. |...  .. |.|.||||.|| |.  |. .||... .|.
ekseeeklplayfglfDGhaGsgaalvaskllhkhlkekl
subfamily_PHLPP_pd Subfamily PHLPP 107-303 2.5e-09 29.4 In-house 25-212 (246) alignment 
Range on Protein: 107-303
Range on HMM: 25-212/246.0
SSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAQSIKRCLVDSFKKTDSDFLSLAAKATPSWKDGSTVAIIMAidNVLYSGNLGDSKSVIYRR
|  . ||.|||.. .  |.     .. |. ..  |.    . .|  |. . .|  ..   | . |       ..|    .   .| . . |  ..|. |.
svealyGlfdGdrneelssllqrlmkdvlkeevqkdkneeeymkntllvaqrklGeaGeklgsaallilirhdkvdPaks..fsLevAsvGtlqavliRn

SGKGDTGGeptvvSVPLTKDHTSAIggKEEDRKIW-EGRIMGIMEVSRSIGDGrFKGCGLVATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFI
. |    .     |  . ||  . |  ||.   |  ...| |..| .| .|   |    .. .|||.   |||.| ...|  . ||.|. .||... .
gkklrlsk.....syviekdelkri..keakaiitednkingviestrllGyt.flfPvvlPkphvrevlLteqdellivGnkalWevlsideaveav
subfamily_PPM1K_pd Subfamily PPM1K 108-306 1.1e-21 70.2 In-house 30-228 (263) alignment 
Range on Protein: 108-306
Range on HMM: 30-228/263.0
SVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDvsaqSIKRCLVDSFKKTDSDFLSL---AAKATPSWKDGSTVAIIMAID-NVLYSGNLGDSKSVI
 . |..|||||.|| | .|.  .|.... . ..||.     ..  |...|.. | .. .        .   . |.| .. .  | . |   .||||....
ellyvavfdGhaGsaaadfvhdklekilkrllekek....dleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrail

YRrSGKGDTGGEPTVVSVPLTKDHTSAIGGKEEDRKIWEGRIMGIMEVSRSIGDGRFKGCGLVATPHVSRCEL-TENDLFVVVACDGLWNVFKMDEVAKF
 |  ||     .    .    |.   | ||. |   . . .. | . ..||.||  .|  |..|||.  . ..  ..| |.|.  ||. .| .  |....
cr.nGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdl

ILGV
.   
vrlc
Subfamily Dicty-PPM1L-like 108-157 1.3e-09 30.4 In-house 36-84 (305) alignment 
Range on Protein: 108-157
Range on HMM: 36-84/305.0
SVSYYGVFDGHSGSRASEFAAGNLhRVIVNKFPKEDVSAQSIKRCLVDSF
  |..||||||.| .|.|..  .|   ||||. ||.   .| |   ||. 
elslfGvfdGhnGdiaaeyvkkkl.veivnkyvkenkvGysaknlnvddl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 111-239 1.3e-09 31.0 In-house 22-141 (292) alignment 
Range on Protein: 111-239
Range on HMM: 22-141/292.0
Y-YGVFDGHS--GSRASEFAAGNLHRVIVNKFPKEdvsaQSIKRCLVDSFKKTDSDFLSLAAKATPSwkDGSTVAIIMAIDN-VLYSGNLGDSKSVIYRR
.   |.|||   | . ...|. .|   ... ...     | .   |.    .. . .  | ..|  |   ...|   .  |.  |.  |.|||.....| 
flaavldGhGvnGdkvaqlaedtlevelleltrql....qelsealllrildiaakldkltidares..attavvcarvrddralilanvGdsrallgrc

SGKGDTGgeptvvSVPLTKDHTSAIGGkEEDRK
 |  |         .||..||     . |. | 
lggsdye......liPlsrdhkPedPd.erari
subfamily_TAB1_pd Subfamily TAB1 111-165 2.2e-07 23.0 In-house 29-83 (333) alignment 
Range on Protein: 111-165
Range on HMM: 29-83/333.0
YYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAQSIKRCLVDSFKKTDSDFL
 |.||||. |..|..|.. .|   ....  ..... . .|. |   |....  ||
lyavFdGydGnkaakfveqrLvaellleqltdelaeaevkevlkrafeeverkfl
PP2C_SIG_SM00331 112-361 4.2e-08 26.0 In-house 33-216 (217) alignment 
Range on Protein: 112-361
Range on HMM: 33-216/217.0
YGVFDGHSGSRASEFAAGNLHRVIVNKFPKEdvsaqsikRCLVDSFKKTDSDFLSLaakatPSWKDGSTVAIIMAI---DNVLYSGNLGDSKSVIYRrsg
. |.||. .  |.. |.. |. .. . . ..          |.. .|.... . ..        |.. . .... .   .. |.  |.|||  ...|   
lvvaDgmGkGlaAaaassqlrtalrellseg........eelsqalkrlnraiyee.....keekgmfaTlllalydfssgklsyanaGdsrpyllr...

kGDTGGEPTVVsvpltkdhtsaiggkeedrkiWEGRIMGIMEVSRsigdgrfkgcglvatPHVSRCELTENDLFVvVACDGLWNV-----FKMDEVAKFI
  .   |..                       .||...|... ..               . ..  || . ||..  . |||...     |. ... ...
.dgklveilkd.....................vegaplGlepevs...............vdirelelekgdlll.lytDGltearsekgfaeerleeil

LGVVnDESIQKPGEdDRLIQGTEVIGDREYrfevacnrlaveavkrgcTDNVTVLIVD
   | |.. |. .. ... .  | ......                   |..||..|.
edlv.dseaqelaq.kiveellelakgsng..................eDdiTvvvvk
subfamily_PPM1G_pd Subfamily PPM1G 173-305 6.9e-16 51.3 In-house 292-427 (473) alignment 
Range on Protein: 173-305
Range on HMM: 292-427/473.0
PSWKDGSTVAIIMAIDNVLYSGNLGDSKSVIYRRsgkgdtggeptVVSVPLTKDHTSaIGGKEEDR------KIW-EGRIMGIMEVSRSIGDGRFKGCG-
|  . |.|  ...  .. |.  | |||..|. |             . . |  ||   .  .| .|      |.  .||. | . .|| .||  .|    
pGedsGttAvvaLlkekklivAnaGDsRcvlsrn...........GkAldlslDHkP.eDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkknee

-------LVATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILG
       . | | .   .|||.| |.|.||||.||| . .||  |.  
LplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvra
subfamily_PP2D1_pd Subfamily PP2D1 185-356 2.5e-11 36.0 In-house 184-353 (492) alignment 
Range on Protein: 185-356
Range on HMM: 184-353/492.0
MAIDNVLYSGNLGDSKSVIYRRsGKGDTGGEPTVVSVPLTKDHTSAIGGKEEdRKIWEGRIMGIMEVSRS---IGDGRFKGCgLVATPHVSRCELTENDL
. .  |||  | |. . |. |  ||. .         .  ..  .  |.    ..   |.. ||... |    .||.. |   ..  |..   .|.|.. 
leelgvlyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvv.kseknglvnGildttRGLGnyGdpkLkks.vipePkttsvkldeaaq

FVVVACDGLWNVFKMDEVAKFILGVVN--DESIQKPGEDDrliqgTEVI-GDREYRFEVACNRLAVEAVKRGCTDNVT
|.|.|  |||.|.. .||.. . ....   .....    |     ..|     .|  |. ...|. .  . | .  ||
flvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvpd.....sdvttvgedylgEleakklsaryentgfdkfvt
subfamily_PPM1H_pd Subfamily PPM1H 243-314 1.2e-06 20.5 In-house 275-358 (404) alignment 
Range on Protein: 243-314
Range on HMM: 275-358/404.0
GRIMGIMEVSRSIGDGRFKGCG--------LVATPHVSRCELTE----NDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQK
 |... . |.| .||   | .         | ..|.|.  .||.    .|  ...| ||||.| . .|||. .  |... . . 
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskveped
Subfamily Dicty-PPM1L-like 246-361 2.2e-10 32.8 In-house 202-302 (305) alignment 
Range on Protein: 246-361
Range on HMM: 202-302/305.0
MGIMEVSRSIGDGRFKgCgLVATPHVSRCEL--TENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQKpgeddRLiqgtevigdrEYRFEVACNRLA
 .....|||.||.  | . ||. .  |        || |.|.| ||||.|.. ..| .... ...|.|.||     ..          |. |.   .. .
nrllkksrskGdknlk.e.lviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqk.....ki..........ewdfneisrviv

VEAVKRGCTDNVTVLIVD
 ||||||  ||.|..|. 
eeavkrgsgDnitlviik
subfamily_PDP_pd Subfamily PDP 265-316 3e-09 29.5 In-house 270-321 (398) alignment 
Range on Protein: 265-316
Range on HMM: 270-321/398.0
LVATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQKPG
| |.| |   .|.||| |.|.| ||||.... .||.. .   ....  ..| 
ltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv