Gene ILKAP-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily ILKAP
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP204_AA protein Get Run
AqueP204_AA_5-322 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ILKAP_pd Subfamily ILKAP 5-322 8.5e-150 490.8 In-house 2-292 (293) alignment
Range on Protein: 5-322
Range on HMM: 2-292/293.0
RYQLRGYHGERRGEREEMQDSHVIINDMMEQfPTLSNSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSA--QSIKRCLVDSFKKTDSDF
.|.|.|...||.||||||||.|||..|..|| ..|..|.||.||||.|||||.||||||||| .||..|..|.||.||||  ..||.||||||||||..|
lyklkgayaerkGereemqdahviledldeq.lrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeef

LSLAAKATPSWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDEGDTggeppVISVPLTKDHTSAsvsyifdydffiifcffQLEERKRIEKSGGFVRE
|.||.||.|.||||||.......|||||..||||||.|..|...|||.     ..||.||||||..                 ..||||||.|.||.||.
LklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdk.....iasvvLtkdhtpv.................kyeerkriqkaGgvvrd

GRIMGIMEVSRSIGDGRFKGCGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDEsiqkpgEDDRLIQGTEVVSDREYRFEVACNRL
||..|..||||||||||||..|.|.||.|..|||||||||||.||||||.||..|||.|||| |..||      |||| |...|..|..|.|||||||||
grvlGvlevsrsiGdgrfkrlGvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvlede......eddrkikeeekkskeevrfevacnrl

AVEAVKRGCTDNVTVLIVDI
|.||||||..||||||.|.|
aseavkrgssdnvtvllvki

0034914 PP2C-like 6-322 1.1e-56 184.9 In-house 19-290 (295) alignment
Range on Protein: 6-322
Range on HMM: 19-290/295.0
YQLRGYHGERRGEREEMQDSHVIINDMMEQFPTlsnspvssVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPK----EDVSAQSIKRCLVDSFKKTDSD
..|| ..   .| |....|..... ... ...         ....||||||.|..|.|.|. .|.. ... . |     . |  .|...|...|...| .
lllrvgvasdqGrrksneDavlvvlnllslled........lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadee

FLSLAAKATPSWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSdegdtggeppvISVPLTKDHTsasvsyifdydffiifcFFQLEERKRIEKSGGFVR
.|.|| .    .  |.|. ...  .| || .|.|||. |..|.              |.||.||.                 . . .||.||...||.|.
llelallrpelagsGtTavvalirgnklyvanvGDSravllrng...........elvqltvdhk.................pvnelererilsaggavs

EGRIMGIMEVSRSIGDGRFK--------GCGLIATPHVSRCELT-ENDLFVVVACDGLWNVFKMDEVAKFILGVV----Ndesiqkpgeddrliqgtevv
 ||..|.. |.|..|| ..|        . ...|.|.|.  ||| |.| |...|.||||.|.  .|.....  ..    .                    
hgrvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld....................

sdreyrFEVACNRLAVEAVKRGCTDNVTVLIVDI
       |.|...|. .|..||..||.||..|..
......leeaaeeLvdlAlargsrDNiTvvvvrl

PP2Cc_SM00332 11-320 8.1e-55 179.1 In-house 11-274 (274) alignment
Range on Protein: 11-320
Range on HMM: 11-274/274.0
YHG--ERRGEREEMQDSHVIINDMMeqfptlsnsPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDV-SAQSIKRCLVDSFKKTDSDFLSLAA
 .|  .  |.|..|.| ||...|.          . ......||||||.||....|.. .|.. . ..  |..  . ......| ..|..||...|  . 
sygkssmqgwrksmeDahvvvvdlv.........eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeq

KATP-SWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDegdtggeppviSVPLTKDHTSasvsyifdydffiifcfFQLEERKRIEKSGGFVREGRIM
.  .  .. |||. ...  .. ||  |.|||. |..| ..           .|.|..||.                  .. .|||||.|.||.|. ||. 
skelenalsGstavvallkkedlyvanvGDSravlcrngk...........avqlsvdhkp.................edederkRikkaggvvekgrvn

GIMEVSRSIGDGRFK------GCGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDEsiqkpgeddrliqgtevvsdREYRFEVACN
|  .|||..||. .|        ...|.|.|. ..||..| |...|.||||.|.. .|| ...    . .                     . . . |..
gglavsrafGdhflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg....................ktndpqeaae

RLAVEAVKR-GCTDNVTVLIV
.|. || .| |..||.||..|
lldeeairrggseDniTvvvv

0049733 PP2C-like 14-321 1.1e-42 139.0 In-house 9-232 (235) alignment
Range on Protein: 14-321
Range on HMM: 9-232/235.0
ERRGE-REEMQDSHVIindmmeqfptlsnspvsSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKedVSAQSIKRCLVDSFKKTDSDFLSLAAKATPS
 ..|  |....|....                 ......|.|||.|..|.|.|...|...... . .   .  .....|...|..... .|.|| .  . 
sdigrvrkvneDavlv.................glllfavaDGhgghaagevasellvetllellle..lllldleealrkaflaaneallelalaspel

WKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRrsdE-GdtggeppviSVPLTKDHTSAsvsyifdydffiifcffQLEERKRIEKSGGFVregRIMGIMEV
.  |.|.....  .. ||  |.|||  ...|   .            |.||.||. .                 . .||.||.. ||.|   |..|.  .
agmgtTavvalldggklyvanvGDsrayllr...dgk.........lvqltedhspv.................nelerqriitaggav...rvpgrlal

SRSIGDGRFKgcgliatPHVSRCELTENDlFVVVACDGLWNVFKMDEVAKFILGvvNDEsiqkpgeddrliqgtevvsdreyrfEVACNRLAVEAVKRGC
.|..||  .|       |.|...||...| |...|.||||.|.  .|..... .  .|                          | |..||. .|..|| 
tralGdlllk.......pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs..ldl.........................eeaaerlvelalargg

TDNVTVLIVD
.||.||..|.
rDNiTvvvvr

PPM_PTC7_SpoIIE 14-279 9.1e-22 71.0 In-house 7-221 (230) alignment
Range on Protein: 14-279
Range on HMM: 7-221/230.0
ERRGEREEMQDSHVIINDMMEQfptlsnSPVSSVSYYGVFDGHSGSRasEFAAGNLHRVIVNKFpKEDVSaqSIKRCLVDSFKKTDSDF--Lslaakatp
. .| |..| |.|.. ....        |. ... ..|..||| |.    .|.| |. .. .   ... .    . .| ... . . |.           
aaqgarksmedahispanseks......sggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..kpeeilrrlnlalaadlede........

SWKDGSTVAIIM--AMDNVLYSGNLGDSKSVMYRRsDEGdtggeppvisvpltkdhtsasvsyifdydffiifcffqleERKRIeKSGGFVR----EGRI
 .. |.|. ..    ... ||  |.|||  ...|  |.|                                        ||.|| ..||...    .||.
psssgaTavvalidpstgklyvanaGdsppllvrd.dgg........................................ereri.vagglpslGilpgrv

MGIMEVSRSIGDGRFKG--CGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQKPGEDD
 |  .||...||  ..       | |. |. || ..| |...|.||||.|   .|.. ...  ...   .. .|||
fgvlavslapGdllllytDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekpaaeglleDD

PP2C Protein phosphatase 2C 14-168 3.3e-21 69.0 Pfam-A 7-143 (255) alignment
Range on Protein: 14-168
Range on HMM: 7-143/255.0
ERRGEREEMQDSHVIINDMMEQfptlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSaqSIKRCLVDSFKK-TDSDFLSLAAKAtPS
| .| |..| |.|.........      |. |||....||||| |..|...|. .|. .. ..  ...      ...| .|| . ||. . | .|..   
elqgarksmedahialknleks......sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfladtdeelksskant.ep

WKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDEGdtggeppvisVPLTKDHTSA
.| |||  ...  .. ||  |.|||. |. |....           . ||.||. .
sksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkps

PP2C Protein phosphatase 2C 14-168 3.3e-21 69.0 In-house 7-143 (255) alignment
Range on Protein: 14-168
Range on HMM: 7-143/255.0
ERRGEREEMQDSHVIINDMMEQfptlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSaqSIKRCLVDSFKK-TDSDFLSLAAKAtPS
| .| |..| |.|.........      |. |||....||||| |..|...|. .|. .. ..  ...      ...| .|| . ||. . | .|..   
elqgarksmedahialknleks......sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfladtdeelksskant.ep

WKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDEGdtggeppvisVPLTKDHTSA
.| |||  ...  .. ||  |.|||. |. |....           . ||.||. .
sksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkps

PPM_PTC7 14-167 1.6e-20 66.7 In-house 7-143 (259) alignment
Range on Protein: 14-167
Range on HMM: 7-143/259.0
ERRGEREEMQDSHVIINDMMEQfptlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSaqSIKRCLVDSFKK--TDSDFLSLAAKAtP
. .| |..| |.|.. .... .      |. .||....||||| |..|...|. .|. .. ..  .|.      ...| .|| .  ||. . | .|..  
afqgfrksmedahialanless......sgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelksseant.e

SWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDEGdtggeppvisVPLTKDHTS
... |||  ...  .. ||  |.|||. |. |. ..           ..||.||. 
pstsGstAvvalitgsklyvAnvGDSravLcrsgnav..........kqltedHkp

subfamily_PPM1A_pd Subfamily PPM1A 15-145 4.4e-19 61.9 In-house 19-145 (282) alignment
Range on Protein: 15-145
Range on HMM: 19-145/282.0
RRGEREEMQDSHVIINDMMeQfptLsnspvSSVSYYGVFDGHSGSRASEFAAGNLHRVIVN--KF---PKEDVSAQSIKRCLVDSFKKTDSDFLSLAAKA
 .| | || |.|... ..  .   |     .. |.. |||||.||....... .|.. |..  ..    .|. .....|  | ..| ..|..  .| ...
mqgwrvemEDahtvvaslg.a...l.....kdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdl

TPSWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRS
. . | |||.  ..  .. |.  |||||..|..|  
ktadksGsTavtvlvsekhliianlGDsRavlcrng

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 16-270 7.3e-30 97.1 In-house 14-227 (255) alignment
Range on Protein: 16-270
Range on HMM: 14-227/255.0
RGEREEMQDSHVIindmmeqFPTLSNSPVSsvSYYGVFDGHSGSRASEFAAGNLHRVIVNKFpkeDVSAQSIKRCLVDSFKKTDSDFlslaaKATPsWKD
 | |  |.|. ||       . .  . . .   || .||||.|..|..||. .|.... ...   |.   . ...| ...|...  .     .  |    
iGrrptmedelvi.......yGsfrdksde..dyyalfdGhgGraaakfaseelykilaell...dlnnanPvkslkkaykeistqi.....serp.kfi

GSTVAIIMAMDNVLYSGNLGDSKSVMYrrsdegdtggeppvisvplTKDHTSASVSyiFDYDffiifcFFQLEERKRIEKSGGFVREG----RIMGIMEV
|.| | .. ...  |  |.|||. |.                     || |.  .|  .|.         . .|.|||.. ||.| ..    |. | . |
GttaasvliiedkvyianvGdsrvvlc...................qkdgtakrls..ldhk......PseeseekriselGGtvvstvvtsrvnGtlav

SRSIGDGrFKGCGLIATPHVS-RCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDE
||..||  |    ... |..|   | ...| |...||||.|..   .|  . ..|. . |
sralGds.flePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpe

subfamily_PPM1E_pd Subfamily PPM1E 16-144 1.7e-22 72.9 In-house 12-131 (265) alignment
Range on Protein: 16-144
Range on HMM: 12-131/265.0
RGEREEMQDSHVIINDMMEQFPTlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAqsikRCLVDSFKKTDSDFLSLAAKAtpSWKD
...|  | | ||...|. | |     .  .  ....|||||.|. |...|| .||...|..   .. .|    . | ..||.||. ||. |..   ..| 
knkrrkmEDrhvaledlnelfel...kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa....ealkeafkltDerflqkaere..klks

GSTVAIIMAMDNVLYSGNLGDSKSVMYRR
|||  ...   . || . ||||.... | 
GstavvvliekdqlyvaWlGDsqallvrk

subfamily_PPM1D_pd Subfamily PPM1D 16-169 9.9e-17 54.0 In-house 10-157 (309) alignment
Range on Protein: 16-169
Range on HMM: 10-157/309.0
RGEREEMQDSHVIINDMMEQFPtlsnspVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAQSIKRCLVDSFKKTDSDFLSLAAKATPSW--
.|.|. |.|  .|  .  |.          .|.. .||||| |  |..||  .|  || ..      . ... . . ..| .| .      .. ..    
qGgrkymeDvvaivleeeesae......elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksg

---KDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDegdtgGEPPVISVPLTKDHTSAS
     |.|.....  .. || .. |||. |.  . .     .|. ... .|||||   |
llstaGttasvviirreklyvahvGDsaivlgvkep.....kekklrakeltkdHkPes

subfamily_PPM1G_pd Subfamily PPM1G 16-102 8.8e-08 24.6 In-house 27-99 (473) alignment
Range on Protein: 16-102
Range on HMM: 27-99/473.0
RGEREEMQDSHVIINDMMEQfptlsnspvssVSYYGVFDGHSGSRASEFAAGNLHRVIVNKfpkEDVSAQSIKRCLVDSFKKTDSDF
 | |... |.|  | |. |.           .| ..|.||| |.  ... | .|  .. ..   .   .  ....| ..| . |.  
qGwrvsqEDahncitdlded...........tslfavyDGHGGkevakyvakklpdllkaq...kgykegdvekaleeaflalDekl

subfamily_PPM1L_pd Subfamily PPM1L 17-267 5.9e-26 84.3 In-house 14-236 (269) alignment
Range on Protein: 17-267
Range on HMM: 14-236/269.0
GEREEMQDSHVIINDMMEQfptlsnspvSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKF-----PKEDVSAQSIKRCLVDSFKKTDSDFLSLAAKATP
| |..|.|   | .|. ..          . |...||||| |  |.|||   | . | ||.      ||.    . .. |.|     | ..|  | .|. 
Grrprmedrfeieediknk.........tgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraed

swKDGSTVAIIMAMDNVLYSGNLGDSKSVMYrrsdegDTGGeppvISVPLTKDHTSasvsyifdYdffiifcffQLEERKRIEKSGGFVR---EGRIMGI
    |.|. | .  .. |   |.|||. |.|      |. |    ...||. ||          .         |..|||||.|.|||.      |. |.
..iaGttalialvqesdlivanvGdsrGvly......dkrG....kaiplsfdhkp........q.........qvkerkrikkaGGfiafrGvwrvaGv

MEVSRSIGDGRFKGCGL-IATPHVSRCELTEN-DLFVVVACDGLWNVFKMDEVAKFILGVV
. .||..||  .|   | ||.| .   .| .    |...|.||||. |  .|  .||.  .
latsralGdyplkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerl

subfamily_PPM1G2_pd Subfamily PPM1G2 17-145 4.9e-21 67.9 In-house 28-145 (287) alignment
Range on Protein: 17-145
Range on HMM: 28-145/287.0
GEREEMQDSHVIINDmmeqfpTLSNSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNkfpKEDVSAQSIKRCLVDSFKKTDSDFLSLaaKATPSWKDG
| | .| |.|.. |.       |..|  .|.....||||| |......|. .|...|..   |.. . ......| |.|..||...|.   ...   . |
GyrlnmeDahilene......lleksddkslalfavfDGhGGakvakyagkklikkiak...kksfkegaleqilkdafletDeellkd..eklkdesaG

STVAIIMAMDNVLYSGNLGDSKSVMYRRS
||  ... ... || .| |||..|.  ..
stavvvlikeeklyvanaGDsravlsskg

subfamily_KAPP-like_pd Subfamily KAPP-like 22-143 1.7e-07 23.6 In-house 12-132 (266) alignment
Range on Protein: 22-143
Range on HMM: 12-132/266.0
MQDSHVIINDMMEQfPTLSNspVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPK---EDV--SAQSIKRCLVDSFKKTDSDF-----LSLAAKATP
|.| .. |  ....   |||  .| .. ..|||||.|  |.. |   . ... ..  .   .|   .    .. | ..||. |. .        .|  . 
medvslaiypllke.kklsn..csnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlal

SWKDGstvaiimaMDNVLYSGNLGDSKSVMYR
 |.||            | ..|.||| . . |
vwsdG........qqrylqvanvGdssaflsr

subfamily_PP2D1_pd Subfamily PP2D1 22-85 7.5e-07 21.2 In-house 17-71 (492) alignment
Range on Protein: 22-85
Range on HMM: 17-71/492.0
MQDSHVIINDMMEQfptlsnspvSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAQ
|.| ... .. ...           ....|..||. |. | | || .||.|....  | | . .
meDkrtlqdyfgnd.........vnscFfgiyDGynGataAeiaakelhevlleelekvdervs

subfamily_PPM1H_pd Subfamily PPM1H 39-77 7.2e-07 21.3 In-house 54-92 (404) alignment
Range on Protein: 39-77
Range on HMM: 54-92/404.0
LSNSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKF
 |...  .. |.|.||||.|| |.  |. .||... .|.
kseeeklplayfglfDGhaGsgaalvaskllhkhlkekl

Subfamily Dicty-PPM1L-like 46-321 3.5e-23 74.9 In-house 36-302 (305) alignment
Range on Protein: 46-321
Range on HMM: 36-302/305.0
SVSYYGVFDGHSGSRASEFAAGNLhRVIVNKFPKEDVSAQSIKRCLVDSF-----KKT--DSDFLSLAAKATPSWKDGSTV-----AIIMAMDNVLySGN
  |..||||||.| .|.|..  .|   ||||. ||.   .| |   ||.      |..  ..|  ||.   . . | |.|.     ..|.  .... . .
elslfGvfdGhnGdiaaeyvkkkl.veivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnkkaGttlngssasvilererti.vst

LGDSKSVMYrrsdEGDTGGEPPVISVPLTKDHTsaSVSYiFDYDFFIIFCFFQLEERKRIEKSGGFV-REGRI--MGIMEVSRSIGDGRFKgCgLIATPH
 .|...|.      | .     .|  |        |  . . .. .     |. |.| |||  .. .   |..   .....|||.||.  | . |.. . 
asdtevvls....sGaiaeglsiinsPkgvgfd..spgw.mkfnhlynqnnfldeiririeslqaalynygellvnrllkksrskGdknlk.e.lviPnn

VSRCEL--TENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQKpgeddRLiqgtevvsdrEYRFEVACNRLAVEAVKRGCTDNVTVLIVD
 |        || |.|.| ||||.|.. ..| .... ...|.|.||     ..          |. |.   .. . ||||||  ||.|..|. 
dspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqk.....ki..........ewdfneisrviveeavkrgsgDnitlviik

subfamily_PPM1K_pd Subfamily PPM1K 46-145 3.8e-11 35.6 In-house 30-129 (263) alignment
Range on Protein: 46-145
Range on HMM: 30-129/263.0
SVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDvsaqSIKRCLVDSFKKTDSDFLS---LAAKATPSWKDGSTVAIIMAMD-NVLYSGNLGDSKSVM
 . |..|||||.|| | .|.  .|.... . ..||.     ..  |...|.. | .. .   .    .   . |.| .. .  | . |   .||||....
ellyvavfdGhaGsaaadfvhdklekilkrllekek....dleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrail

YRRS
 |. 
crnG

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 49-165 2e-08 27.1 In-house 22-130 (292) alignment
Range on Protein: 49-165
Range on HMM: 22-130/292.0
Y-YGVFDGHS--GSRASEFAAGNLHRVIVNKFPKEdvsaQSIKRCLVDSFKKTDSDFLSLAAKATPSwkDGSTVAIIMAMDN-VLYSGNLGDSKSVMYRR
.   |.|||   | . ...|. .|   ... ...     | .   |.    .. . .  | ..|  |   ...|   .  |.  |.  |.|||.....| 
flaavldGhGvnGdkvaqlaedtlevelleltrql....qelsealllrildiaakldkltidares..attavvcarvrddralilanvGdsrallgrc

SDEGDTggEPpvisVPLTKDH
    |   |.    .||..||
lggsdy..el....iPlsrdh

subfamily_TAB1_pd Subfamily TAB1 49-103 2.2e-07 23.0 In-house 29-83 (333) alignment
Range on Protein: 49-103
Range on HMM: 29-83/333.0
YYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAQSIKRCLVDSFKKTDSDFL
 |.||||. |..|..|.. .|   ....  ..... . .|. |   |....  ||
lyavFdGydGnkaakfveqrLvaellleqltdelaeaevkevlkrafeeverkfl

PP2C_SIG_SM00331 50-321 3.9e-06 19.6 In-house 33-216 (217) alignment
Range on Protein: 50-321
Range on HMM: 33-216/217.0
YGVFDGHSGSRASEFAAGNLHRVIVNKFPKEdvsaqsikRCLVDSFKKTDSDFLSLaakatPSWKDGSTVAIIMA---MDNVLYSGNLGDSKSVMYRrsd
. |.||. .  |.. |.. |. .. . . ..          |.. .|.... . ..        |.. . ....     .. |.  |.|||  ...|   
lvvaDgmGkGlaAaaassqlrtalrellseg........eelsqalkrlnraiyee.....keekgmfaTlllalydfssgklsyanaGdsrpyllr...

E----GDTGGeppvisvpltkdhtsasvsyifdydffiifcffqleerkrieksggfvREGRIMGIMEVSRsigdgrfkgcgliatPHVSRCELTENDLF
.     ..                                                   ||...|... ..               . ..  || . ||.
dgklveilkd................................................vegaplGlepevs...............vdirelelekgdll

VvVACDGLWNV-----FKMDEVAKFILGVVnDESIQKPGEdDRLIQGTEVVSDREYrfevacnrlaveavkrgcTDNVTVLIVD
.  . |||...     |. ... ...   | |.. |. .. ... .  | . ....                   |..||..|.
l.lytDGltearsekgfaeerleeiledlv.dseaqelaq.kiveellelakgsng..................eDdiTvvvvk

subfamily_PPM1G_pd Subfamily PPM1G 111-267 3.8e-19 62.0 In-house 292-429 (473) alignment
Range on Protein: 111-267
Range on HMM: 292-429/473.0
PSWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRsdegdtggeppvisvpltkdhtsasvsyIFDYDFFIIFCFFQLEERKRIEKSGGFVR-EGRIMGIM
|  . |.|  ...  .. |.  | |||..|. |                                 |. .       .|..|||| || |  .||. | .
pGedsGttAvvaLlkekklivAnaGDsRcvlsrn............................GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGL

EVSRSIGDGRFKGCG--------LIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVV
 .|| .||  .|           . | | .   .|||.| |.|.||||.||| . .||  |.   .
nlsRAlGDhaYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvrakl

subfamily_PHLPP_pd Subfamily PHLPP 186-263 5.1e-10 31.6 In-house 135-212 (246) alignment
Range on Protein: 186-263
Range on HMM: 135-212/246.0
QLEERKRIEKSGGFVRE-GRIMGIMEVSRSIGDGrFKGCGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFI
. .| ||| .  ... | ..| |..| .| .|   |    .. .|||.   |||.| ...|  . ||.|. .||... .
ekdelkrikeakaiitednkingviestrllGyt.flfPvvlPkphvrevlLteqdellivGnkalWevlsideaveav

PP2C Protein phosphatase 2C 187-315 6.7e-26 84.4 Pfam-A 145-255 (255) alignment
Range on Protein: 187-315
Range on HMM: 145-255/255.0
LEERKRIEKSGGFVR-EGRIMGIMEVSRSIGDGRFKG---CGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESiqkpgeddrli
 .||.|||..||.|  .||. | ..|||..|| ..|    .  .| |.|.  .|||.| |...|.||||.|.. .|.. ..   .....           
edEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk...........

qgtevvsdreyRFEVACNRLAVEAVKRGCTDNV
             . |...|. ||..||..||.
...........spmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 187-315 6.7e-26 84.4 In-house 145-255 (255) alignment
Range on Protein: 187-315
Range on HMM: 145-255/255.0
LEERKRIEKSGGFVR-EGRIMGIMEVSRSIGDGRFKG---CGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESiqkpgeddrli
 .||.|||..||.|  .||. | ..|||..|| ..|    .  .| |.|.  .|||.| |...|.||||.|.. .|.. ..   .....           
edEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk...........

qgtevvsdreyRFEVACNRLAVEAVKRGCTDNV
             . |...|. ||..||..||.
...........spmeaaeelvdeaiargsedni

subfamily_PPM1G2_pd Subfamily PPM1G2 187-266 1.4e-16 53.3 In-house 159-246 (287) alignment
Range on Protein: 187-266
Range on HMM: 159-246/287.0
LEERKRIEKSGGFVREGRIMGIMEVSRSIGDGRFKGCG--------LIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGV
 .|.|||...||||  .|. | . .||..||  || .           |.| |   .|.|.| |.|.||||.|.|.. .|| ...   
esekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrer

subfamily_PPM1A_pd Subfamily PPM1A 188-321 4.5e-24 78.3 In-house 160-279 (282) alignment
Range on Protein: 188-321
Range on HMM: 160-279/282.0
EERKRIEKSGGFVREGRIMGIMEVSRSIGDGRFKG--------CGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDE-S---Iqkp
.|.||||. ||.|  .|..| . |||..||  .|           ..| |.|  .| .|.| |.|.||||.| | . .||....   ..       .   
kEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev...

geddrliqgtevvsdreyrfevaCNRLAVEAVKRGCTDNVTVLIVD
                       ...|  .| ..| .||..||.| 
.......................akalvdkalekgsrDNlsvlvvl

PPM_PTC7 188-315 8.1e-24 77.4 In-house 147-259 (259) alignment
Range on Protein: 188-315
Range on HMM: 147-259/259.0
EERKRIEKSGGFVR---EGRIMGIMEVSRSIGDGRFKG-----CGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDEsiqkpgedd
.||.|||..||.|    .||. |  .|||..|| ..|      . ..|.|..|  ...|.| |...|.||||.|.  .|.. ..  .....         
dEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.........

rliqgtevvsdreyRFEVACNRLAVEAVKRGCTDNV
                . |...|. ||..||..||.
..............dpmeaaeklvdeaiargsedni

subfamily_PPM1E_pd Subfamily PPM1E 188-274 2.1e-17 56.2 In-house 147-235 (265) alignment
Range on Protein: 188-274
Range on HMM: 147-235/265.0
EERKRIEKSGGFVR---EGRIMGIMEVSRSIGDGRFKGCgLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQK
.|.||||. ||.|    . |. |.. |||.||| . |   ... . |...||.... ....||||||.|.. .|| | .   ..|.. ..
dEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpy.vsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedl

subfamily_PP2D1_pd Subfamily PP2D1 188-316 2.8e-14 45.7 In-house 221-353 (492) alignment
Range on Protein: 188-316
Range on HMM: 221-353/492.0
EERKRIEKSGGFVR----EGRIMGIMEVSRS---IGDGRFKGcGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVN--DESIQKPGED
.||.|.||.|. |      |.. ||... |    .||.. |   .|  |..   .|.|.. |.|.|  |||.|.. .||.. . ....   .....    
kERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkk.svipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvp

DrliqgTEVV-SDREYRFEVACNRLAVEAVKRGCTDNVT
|     ..|     .|  |. ...|. .  . | .  ||
d.....sdvttvgedylgEleakklsaryentgfdkfvt

subfamily_KAPP-like_pd Subfamily KAPP-like 188-259 1.3e-12 40.4 In-house 149-224 (266) alignment
Range on Protein: 188-259
Range on HMM: 149-224/266.0
EERKRIEKSGGFVREG--RIMGIMeVSRSIGDGRFK--GCGLIATPHVS-RCELTENDLFVVVACDGLWNVFKMDEV
||..|| . |  . ..  || |.. |||..||   |   .|||..|.|| |  ||  | |..|| ||||.| . .. 
eekqrikddGitlsdnqtrinGla.vsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkda

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 188-259 1.4e-12 40.1 In-house 159-234 (276) alignment
Range on Protein: 188-259
Range on HMM: 159-234/276.0
EERKRIEKSGGFVREG--RIMGIMeVSRSIGDGRFK--GCGLIATPHVS-RCELTENDLFVVVACDGLWNVFKMDEV
||..|| . |  . ..  || |.. |||..||   |   .|||..|.|| |  ||  | |..|| ||||.| . .. 
eekqrikddGitlsdnqtrinGla.vsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkda

subfamily_PPM1K_pd Subfamily PPM1K 188-266 2.1e-10 33.2 In-house 144-228 (263) alignment
Range on Protein: 188-266
Range on HMM: 144-228/263.0
EERKRIEKSGGFVR-----EGRIMGIMEVSRSIGDGRFKGCGLIATPHVSRCEL-TENDLFVVVACDGLWNVFKMDEVAKFILGV
||..|| ..||.|      . .. | . ..||.||  .|  |.||||.  . ..  ..| |.|.  ||. .| .  |.....   
eekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlc

subfamily_PPM1H_pd Subfamily PPM1H 201-320 2.9e-07 22.6 In-house 273-400 (404) alignment
Range on Protein: 201-320
Range on HMM: 273-400/404.0
REGRIMGIMEVSRSIGDGRFKGCG--------LIATPHVSRCELTE----NDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQKPGEDDRLIQgtEVV
.  |... . |.| .||   | .         | ..|.|.  .||.    .|  ...| ||||.| . .|||. .  |... . . .     . |  |.|
kkaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkrytavaq..eLv

SDREYRFEVACNRlaVEAVKRGCTDNVTVLIV
     ...    |  ..  | . .|...|...
aaarGklkdkgWr..lkeekaasvDDisvfvi

subfamily_PDP_pd Subfamily PDP 225-277 1.3e-09 30.7 In-house 270-322 (398) alignment
Range on Protein: 225-277
Range on HMM: 270-322/398.0
LIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQKPGE
|.|.| |   .|.||| |.|.| ||||.... .||.. .   ....  ..| .
ltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvk