Gene PPM1D-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP209_AA protein Get Run
AqueP209_AA_5-330 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 6-330 1.7e-54 177.6 In-house 19-291 (295) alignment
Range on Protein: 6-330
Range on HMM: 19-291/295.0
VTISVTAETNAGGRKHMEDYIAVSLSP-----KesllsnpemreQAFVGVFDGHGGKEAAKYARENLWSVIQDQ----SNFLTQDPQSVREAISNAYLQL
  ..| . .. | ||..||.. | |.      .           ....|||||||| .||..|.|.|.. . ..     ..|| .. ...||. .|.|..
lllrvgvasdqGrrksneDavlvvlnllslled...........lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaa

HNTMEESRASWvpnktGDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGvRNPrygepgepqiIPKLLTKDHKPEDPEEQENIRRLGGEVALslkgV--M
.. . |   ..      .|.. ||||.....|.|..||||||||  ..  ||            .. ||.|||| ...|.| |...|| |         .
deellelallr.....pelagsGtTavvalirgnklyvanvGDSravll.rng..........elvqltvdhkpvnelererilsaggavsh....grvn

rvvwermrvksngkkeidriPFLSVARSLGDFWSY---SAQSGEYTVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSgsnns
                    ..| | |.||||. .   |    |. ||..|.|. ..|.|.. .|..|||||||.|.|....|...... .||..     
....................gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld.....

sdtnvQRDVVSALIKEALSRWSRkklqaDNIAVLIAYLS
       ... .|...||.|.||     ||| |....|.
.....leeaaeeLvdlAlargsr.....DNiTvvvvrln

subfamily_PPM1A_pd Subfamily PPM1A 6-327 1.6e-45 148.6 In-house 10-278 (282) alignment
Range on Protein: 6-327
Range on HMM: 10-278/282.0
VTISVTAETNAGGRKHMEDYIAVSLSpkesllsNPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNF-----LTQDPQSVREAISNAYLQLHNTM
 .. .. ... | |..|||  .|  |        .......|  |||||.|.|.|||. ..| . | .....       .. ..|.||.....|.|....
nglrygvssmqgwrvemEDahtvvas.......lgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeai

EESRASwvpNKTGdlSTAGTTASTVIFRKNHIYVANVGDSTGIMgVRNPrygepgepqiIPKLLTKDHKPEDPEEQENIRRLGGEVAlslkgVMRVVWEr
.|. ..   .||     .|.|| ||. ...|...||.||| ... .||             . ||.||||..|.|.. |.  ||.|      | ||    
relstd...lkta..dksGsTavtvlvsekhliianlGDsRavl.crng..........kaaflteDHkpsrpkEkkRieqAGGsvv.....vsRvnGa.

mrvksngkkeidripfLSVARSLGDFWSYS---AQSGEYTVSPVPYVYDFPLDLNEQkFIVLASDGLWNVMSPSDVVNFISDFDSKGtSGSNNSsdtnvq
                | |.|.|||.   .    .. |  ||..|.|. .  . ... |.|||.||.| |.| ..||... .  ... .. ..       
................LAvsRalGDyeykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrleva.deleev......

rdvVSALIKEALSRWSRkklqaDNIAVLIA
   ..||...||.. ||     ||..||. 
...akalvdkalekgsr.....DNlsvlvv

subfamily_PPM1D_pd Subfamily PPM1D 8-330 1.6e-137 450.7 In-house 2-308 (309) alignment
Range on Protein: 8-330
Range on HMM: 2-308/309.0
ISVTAETNAGGRKHMEDYIAVSLSPKESLLsnpeMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDPQSVREAISNAYLQLHNTMEESRASW
.|||.|...||||.|||..|..|...||..    ..|.|||.||||||||||||.|||.|||||..|..||...|..|.|||..|.|..|..|......|
lsvtseadqGgrkymeDvvaivleeeesae....elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeW

VPNKTGDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPrygepGEPQIIPKLLTKDHKPEDPEEQENIRRLGGEVALSlKGVMRVVWERMRVKSNG
...|.|.|||||||||.||.|....|||.||||. ..||..|     .|.....| ||||||||.|||.|.|..|||||| . .||.||||.|.|...||
pktksgllstaGttasvviirreklyvahvGDsaivlgvkep.....kekklrakeltkdHkPespeekerieelGGevaak.sGvkRvvWkRprlehng

KKEIDRIPFLSVARSLGDFWSYSAQSGEYTVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSGSNNSsdtnvqRDVVSALIKE
...||.||||.|||||||.|||.|.|||..|||.|.|... || ||.|||.|||||||||..|.|.|..... ..|..  ...|      |.|..||.||
ptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs......rsvakalvke

ALSRWSRKKLQADNIAVLIAYLS
||.||..|||.|||..|.. .|.
alqrwrskklraDnvsvivvile

0049733 PP2C-like 8-329 2.6e-40 131.3 In-house 3-233 (235) alignment
Range on Protein: 8-329
Range on HMM: 3-233/235.0
ISVTAETNAGG-RKHMEDYIAVslspkesllsnpemrEQAFVGVFDGHGGKEAAKYARENLWSVIQdqSNFLTQDPQSVREAISNAYLQLHNTMEESRAS
.|| | .  |  ||..||...|               ......|.||||| .|...|.|.|.....  . .|.... ...||. .|.|.... . |   .
lsvgaasdigrvrkvneDavlv...............glllfavaDGhgghaagevasellvetll..elllelllldleealrkaflaaneallelala

WVpnktgDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGvRNPRygepgepqiiPKLLTKDHKPEDPEEQENIRRLGGEValslkgvmrvvwermrvksn
.      .|.. ||||..........||||||||  ..  |. .             ||.||.| ...|.. |...|| |                    
sp.....elagmgtTavvalldggklyvanvGDsrayll.rdgk..........lvqltedhspvnelerqriitaggav....................

gkkeiDRIPFLSVARSLGDFWSYsaqsgeytvspvPYVYDFPLDLNEqkFIVLASDGLWNVMSPSDVVNFISDFDSkgtsgsnnssdtnvqRDVVSALIK
       .. | . |.|||..              |.|. ..|. ..  |..|||||||.|.|....|..... |                ......|..
.....rvpgrlaltralGdlllk............pdvtvlelepgd..flllasDGlwdvlsdeeivdllrsldl...............eeaaerlve

EALSRWSRkklqaDNIAVLIAYL
.||.|..|     ||| |....|
lalarggr.....DNiTvvvvrl

subfamily_PPM1E_pd Subfamily PPM1E 8-330 5.5e-37 120.4 In-house 4-263 (265) alignment
Range on Protein: 8-330
Range on HMM: 4-263/265.0
ISVTAETNAGGRKHMEDYIaVSLSPKESLLSNPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFlTQDPQsvreaisnayLQLHNTMEESRASW
..|....  . |..|||   |.|.  ..|.   ...|.|| .||||||| |||||| ..|.... .|... ..||.           .|......   . 
yevsiaavknkrrkmEDrh.valedlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqekl.kedpa..........ealkeafkltDerf

VPNKTGDLSTAGTTASTVIFRKNHIYVANVGDSTGIMgVRNprygepGEpqiiPKLLTKDHKPEDPEEQENIRRLGGEVALSlkGVMRVvwermrvksNG
.   . .  ..|.|| .|. .|...||| .||| ... ||.      ||       |.| ||||...|.. |  .|| |     |..||         ||
lqkaereklksGstavvvliekdqlyvaWlGDsqall.vrk......ge....avqlmkpHkPeredEkkRieeagGlvvvi..gawRv.........nG

KkeidripfLSVARSLGDfwsysaQSGEYTVSPVPYVYDFPLDlNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSgsnnsSdtnvQRDVVSALIKE
         |||.|..||      .. .  ||  . | ...|| .......||.||||.|. ...||. ...| ..|..     .    . .|   |...
v........LsvsRaiGD......vklkpyvsgeadvaeveld.gseeylilacDGlwDvvneeevvklveefladgae.....d....lsevakllvea

ALSRWSrkklqADNIAVLIAYLS
| .. |     .|||.|....|.
akeags.....sDnitvvvvfld

subfamily_PPM1G_pd Subfamily PPM1G 9-101 2.7e-10 32.9 In-house 20-100 (473) alignment
Range on Protein: 9-101
Range on HMM: 20-100/473.0
SVTAETNAGGRKHMEDYIAVSLSPKEsllsnpemrEQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDpqsVREAISNAYLQLHNTME
|..| .  | |. .|| . . .  .|         . .. .|.||||||| |||  ..|  ....|  .   |   |..|...|.|.| ....
sygasamqGwrvsqEDahncitdlde.........dtslfavyDGHGGkevakyvakklpdllkaqkgykegd...vekaleeaflalDeklk

PP2C Protein phosphatase 2C 11-311 4.7e-56 183.2 Pfam-A 4-249 (255) alignment
Range on Protein: 11-311
Range on HMM: 4-249/255.0
TAETNAGGRKHMEDYIAVSLSPKESllsnPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDpqSVREAISNAYLQlHNTMEESR--ASwv
.|... | ||.||| ..   . ..|        . ||..||||||| ||||||||.|. ... |. ||. .   |..|.....|. .  .|  .  |.  
gaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelksskan..

pnkTgDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPRYgepgepqiipKLLTKDHKPEDPEEQENIRRLGGEVALslkgVMRVVWErmrvksngk
   |   |. |.||.....|....||||||||  ... ..  .          | ||.||||.|..| | |...||.|      . ||..          
...t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsn....ngrvngs.........

keidripfLSVARSLGDFWSYSAQsgEYTVSPVPYVYDFPLDLNeQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTsgsnnssdtnVQRDVVSALIKEA
        |.|.|.||||.... .  |. ||. |.|. ..|. .  .|..|||||||.|.|. ..| .. .. ||..            ...  .|..||
........LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk..........spmeaaeelvdea

LSR
..|
iar

PP2C Protein phosphatase 2C 11-311 4.7e-56 183.2 In-house 4-249 (255) alignment
Range on Protein: 11-311
Range on HMM: 4-249/255.0
TAETNAGGRKHMEDYIAVSLSPKESllsnPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDpqSVREAISNAYLQlHNTMEESR--ASwv
.|... | ||.||| ..   . ..|        . ||..||||||| ||||||||.|. ... |. ||. .   |..|.....|. .  .|  .  |.  
gaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelksskan..

pnkTgDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPRYgepgepqiipKLLTKDHKPEDPEEQENIRRLGGEVALslkgVMRVVWErmrvksngk
   |   |. |.||.....|....||||||||  ... ..  .          | ||.||||.|..| | |...||.|      . ||..          
...t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsn....ngrvngs.........

keidripfLSVARSLGDFWSYSAQsgEYTVSPVPYVYDFPLDLNeQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTsgsnnssdtnVQRDVVSALIKEA
        |.|.|.||||.... .  |. ||. |.|. ..|. .  .|..|||||||.|.|. ..| .. .. ||..            ...  .|..||
........LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk..........spmeaaeelvdea

LSR
..|
iar

subfamily_PPM1G2_pd Subfamily PPM1G2 11-329 2.2e-35 115.0 In-house 22-286 (287) alignment
Range on Protein: 11-329
Range on HMM: 22-286/287.0
TAETNAGGRKHMEDYIAVSLSpkesLLSNPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLtqdPQSVREAISNAYLQLHNTMEESraswvpN
.. .  | | .|||   .       ||.... .. |...|||||||...|||| ..| ..|. ...|     ....... .|.|.. . . .       .
gssamqGyrlnmeDahilene....lleksddkslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafletDeellkd......e

KTGDlSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRnprygepGepQiiPKLLTKDHKPEDPEEQENIRRLGGEVALSlkgvmrvvwermRVKSNgkke
|. | ..||.|| .|. .....||||.|||  .. ..       |  .   | |. ||||.. .|.. |   || |.|             ||  |    
klkd.esaGstavvvlikeeklyvanaGDsravlssk.......g..n..vkalsfDhkPqeesekkriiaagGfveln............rvngn....

idripfLSVARSLGDFWSYS---AQSGEYTVSPVPYVYDFPLDlNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGtsgsnnssdTNvQRDVVSALIKE
      |...|.||||   .    .. |  |  || |    || ... |.||| ||.|.|.. ..||...    ..|         ..   .... |...
......LalsralgDfefkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsg.........ak.ldeiieelldk

ALSRWSR-KKLQADNIAVLIAYL
.|.. |.   . .||..|.|  |
clapdssntgvGcDnmtvvivvl

PPM_PTC7 13-296 8.5e-55 179.0 In-house 6-238 (259) alignment
Range on Protein: 13-296
Range on HMM: 6-238/259.0
ETNAGGRKHMEDYIAVSLSPKESllsnPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDpqSVREAISNAYLQLHNTMEESRaswvP--N
. . | ||.|||  ..      |        . ||..||||||| ||||||||.|. ... .. | . .   . .|.....|.|.  .|  .    .  |
safqgfrksmedahialanless....sgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks....sean

kTgDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPRYgepgepqiipKLLTKDHKPEDPEEQENIRRLGGEVALSlkGVMRVVWErmrvksngkke
 |   || |.||..........||||||||  ... ..  .          | ||.||||....| | |...||.|     |. ||..            
.t.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav..........kqltedHkpsnedEreRiegaggsvsnv..gngrvngv...........

idripfLSVARSLGDFWSYSAQSGEYTVSPVPYVYDFPLDLNeQKFIVLASDGLWNVMSPSDVVNFISDFDSKGtsgsnnssdtnV
      | |.|..|||.... ...|  ||. |...  ..| . ..|..|||||||.|.|. ..| .. .. ||.            
......lavsRafGdfelkpketeeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk...........d

PP2Cc_SM00332 13-326 3.6e-54 177.0 In-house 15-273 (274) alignment
Range on Protein: 13-326
Range on HMM: 15-273/274.0
ETNAGGRKHMEDYIAVSLSPKesllsnpEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQD-PQSVREAISNAYLQLHNTMEESRASWVPNK
 .. | || ||| ..| .. .       |  . .|.||||||||.|.||.....|.. .... .. ...  ..| ||...|.|.... . |.  |. ...
ssmqgwrksmeDahvvvvdlv.......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen

tgdlSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPrygepgepqiiPKLLTKDHKPEDPEEQENIRRLGGevalslkgvmrvvwermrvkS--NGkk
    ...|.||......|...||||||||  ...  .             . |..||||||..| . |.. ||                    .  .|  
....alsGstavvallkkedlyvanvGDSravlcrngk...........avqlsvdhkpedederkRikkagg....................vvekg..

eiDRIPFLSVARSLGDFWSYSAQ-SGEYTVSPVPYVYDFPLdLNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGtsgsnnssDTNVQRDVVSALIKEA
       |.| |..||..   .. . |  ... | |.   |  .| .|..|||||||.|.|. .||... .. .||         ||   ..   |..||
..rvngglavsrafGdhflkknkklkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakg........ktndpqeaaelldeea

LSRwsrkKLQADNIAVLI
..|    .  .||| |..
irr....ggseDniTvvv

subfamily_ILKAP_pd Subfamily ILKAP 15-327 1e-33 109.8 In-house 12-290 (293) alignment
Range on Protein: 15-327
Range on HMM: 12-290/293.0
NAGGRKHMEDYIAVSLSPK-ESLLSNPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQ---SNFLTQDpQSVREAISNAYLQLHNTMEESRASWVPn
  | |..|.|   .  . . .. |..  .   .. .|||||.|. |...| |.|  .| ..   |.. ... .... .. ... .  . . .  ..  | 
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsake.keikkclvdsfkktdeefLklaskakP.

ktgdLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPRYGEpgepqIIPKLLTKDHKPEdpeeqenirrlggevalslkgvmrVVWERMRVKSNGKK-
        |.|| .|.   | .||||.|||  ..  ...   .     |.   |||||.|                            ||.|..  | . 
....vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdk.....iasvvLtkdhtpv........................kyeerkriqkaGgvv

EIDRI-PFLSVARSLGDFwSYSaqsgEYTVSPVPYVYDFPLDLNeQKFIVLASDGLWNVMSPSDVVNFISDF-DSKGTSGSNNSSDTNVQRDVVSALIKE
. .|.   | |.||.||   .     .  |. .| |    |. |  .|.||| ||||.|.| ..||.||..  ... .. . . .... ...|   .. .
rdgrvlGvlevsrsiGdg.rfk....rlGvistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacn

ALSRWSRKKLQADNIAVLIA
 |.  . |.  .||..||. 
rlaseavkrgssdnvtvllv

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 16-282 7.7e-30 97.0 In-house 14-225 (255) alignment
Range on Protein: 16-282
Range on HMM: 14-225/255.0
AGGRKHMEDYIAVSLSPKEsllsnpeMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDPQsvrEAISNAYLQLHNTMeesraswvpNKTGdl
 | |  ||| ...  | ..         .. .. .||||||..|||.| |.|  ....  .    .|.   ... .|| ...  .         .. .  
iGrrptmedelviyGsfrd.......ksdedyyalfdGhgGraaakfaseelykilaelldlnnanPv...kslkkaykeistqi.........serp..

STAGTTASTVIFRKNHIYVANVGDSTGIMGvrnprygepgEPQIIPKLLTKDHKPEDPEEQENIRRLGGEVALSlkgvmrvvwermrV---KSNGKkeid
   |||| .|.. ....|.||||||  ...          . . . | |. |||| ...|.. |..||| |  .             |   . ||.    
kfiGttaasvliiedkvyianvGdsrvvlc..........qkdgtakrlsldhkPseeseekriselGGtvvst.............vvtsrvnGt....

ripfLSVARSLGDFWSysaqsgEYTVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISDFDS
    |.|.|.||| .       |  | | |.. .     ...||..|| ||.|...|  . |. . .  .
....lavsralGdsfl......ePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisd

subfamily_PPM1L_pd Subfamily PPM1L 16-279 3.5e-26 85.0 In-house 13-234 (269) alignment
Range on Protein: 16-279
Range on HMM: 13-234/269.0
AGGRKHMEDYIAVSLSPKESllsnpemREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDpQSVREAISNAYLQLHNTMEESrASWVPNKTGDL
 | |..||| . .    |..        .. |..|||||||. ||..|.. |   |...   | .| .   | |. . |  .. .       . . .   
lGrrprmedrfeieediknk.......tgesffavfdGhGGefaaefakdvlvkaiknklieldad.kentepinfsklltdeilsvd.ekllekakrae

STAGTTASTVIFRKNHIYVANVGDSTGIMgvrnprYGEPGepQIIPklLTKDHKPEDPEEQENIRRLGGEVAlsLKGVMRVvwermrvKsnGkkeidrip
 .|||||   . ..... ||||||| |..      | . |  . ||  |. ||||....|.  |.. || .|  ..|| ||       .  |        
diaGttalialvqesdlivanvGdsrGvl......ydkrG..kaip..lsfdhkpqqvkerkrikkaGGfia..frGvwrv.......a..G........

FLSVARSLGDfwsYSAQSgEYTVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISD
 |...|.|||   |  .  .  | . | .  | ||  . .|..|||||||. .|  . |.|| .
vlatsralGd...yplkd.knlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfike

PPM_PTC7_SpoIIE 16-280 8.9e-25 80.8 In-house 9-208 (230) alignment
Range on Protein: 16-280
Range on HMM: 9-208/230.0
AGGRKHMEDYIAVSLSPKESllsnPEMREQAFVGVFDGHGGKEaaKYARENLWSVIQDQSnFLTQDpqSVREAISNAYLQLHNTMEESraswvpnktgdL
 | ||.|||  ..      |    .. |  ..||..||||| .  ..|.. |..... .. | . .   . |......|.|.  .|..            
qgarksmedahispanseks....sggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..kpeeilrrlnlalaadlede...........p

STAGTTASTVIFRKNH--IYVANVGDSTGIMGVRNPRygepgepqiipklltkdhkpedpeeqeNIRRLGGEVALSlK----GvmRVVWErmrvksngkk
|. |.||. .... ..  .||||.|||  ..   ...                            ..|...  ..|      |  ||...          
sssgaTavvalidpstgklyvanaGdsppllvrddgg...........................ererivagglps.lGilpg..rvfgv..........

eidripfLSVARSLGDFWSYSaqsGEYTVSPVPYvYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISDF
       |.|... ||.. .     .  |.. |.  .  .. ....|..|||||||.|.|| ..| .. | 
.......lavslapGdlllly...tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrde

subfamily_KAPP-like_pd Subfamily KAPP-like 17-308 4.4e-17 55.0 In-house 7-258 (266) alignment
Range on Protein: 17-308
Range on HMM: 7-258/266.0
GGRKHMED-YIAVSLSPKESLLSNpeMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFlTQDPqSVREAISNAYLQLHNTMEEsraswVPNKTGDL
|   .||| ..|.    ||  |||    . |. .||||| || ||. |.. .  ..... .  |..     . | .    |.|...|     | .|  | 
gcstemedvslaiypllkekklsn..csnialfavfdGhaGkGaadaakklfpkelekllks.tkqd.dGGdniydqskllenafke.....vdaklkdf

STAGTTASTV-IFR---KNHIYVANVGDSTGIMGVRNprygepgePQIipkLLTKDHKPEDPEEQENIRRLGgeVALslkgvmrvvwermrvkSNGKkei
   |.||. . ...   . .. |||||||. ..   |          .    |.|||| .||||.  |.  |  ..|                |...   
eyeGatatlalvwsdGqqrylqvanvGdssaflsrGn........esl...elskdhkakdpeekqrikddG..itl................sdnq...

DRIPFLSVARSLGDFWSYSAQSGeytVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISD-FDSKGTSGSNnsSDTNVQRDVVSALIKEA
 ||  | |.|.||| .    . |   ..  ||| .  |    .||...||||||.|.|  | .. ..  .| . |. .   ... ..  . |.. |. 
trinGlavsralGdhfikelniG...lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkm..asslletaiqsikakdn

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 18-308 2.7e-15 49.0 In-house 7-268 (276) alignment
Range on Protein: 18-308
Range on HMM: 7-268/276.0
GRKHMED-YIAVSLSPKESLLSNpeMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQS---N-FLTQDPQSvREAISNAYLQLHNTMEEsraswVPNKT
   .||| ..|.    .|  |||    . |. .||||| || ||. |.. .  ...      |  ||.. .   . | .    | . ..|     | .| 
cstemedvslaiyplldekdlsn..csnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddG.Gdniydqskllldlfke.....vdakl

GDLSTAGTTAST-VIFRKN---------HIYVANVGDSTGIMGVRNprygepgePQIipkLLTKDHKPEDPEEQENIRRLGgeVALslkgvmrvvwermr
 |    |.||.  .....          .. |||||||. ..   |          .    |.|||| .||||.. |.  |  ..|              
kdfeyeGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGn........esl...elskdhkatdpeekqrikddG..itl..............

vkSNGKkeiDRIPFLSVARSLGDFWSYSAQSGeytVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISD-FDSKGTSGSNnsSDTNVQRDVV
  |...    ||  | |.|.||| .    . |   ..  ||| .  |    .||...||||||.|.|  | .. ..  .| . |. .   ... ..  . 
..sdnq...trinGlavsralGdhfikelniG...lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkm..asslletaiq

SALIKEA
|.. |. 
sikakdn

subfamily_PDP_pd Subfamily PDP 21-180 4.9e-12 38.7 In-house 46-208 (398) alignment
Range on Protein: 21-180
Range on HMM: 46-208/398.0
HMEDYIAVSLSPKESLLSNP-EMREQA----FVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDPQSVREAISNAYLQLHNTMEESRASWVPNKTG--
.. .|.|.|| .|. | .   ......    .. . . . .. . . .. .| .. .   . |  . ..|.||...|.|.| . . .   . ...|.   
rLlkyvaasllkkqvleeaekalesgkallkllkkskhkldvvsdeakklslselskylqelleaevekvkealkkaFlklDkdistealkklkekslre

--DLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPRygepGEpqIIPKLLTKDHKPEDPEEQENIR
  . ...|..| ..  ......|||.||.  ..||....    |.     . |.||.  . .|| | |.
allvalsGacallaliegtelhvAntGDcravlgvqeee....gs..weavkLskdqtadneeEveRik

Subfamily Dicty-PPM1L-like 42-140 1.7e-09 29.9 In-house 34-137 (305) alignment
Range on Protein: 42-140
Range on HMM: 34-137/305.0
MREQAFVGVFDGHGGKEAAKYARENLWSVIQD---------QSNFLTQDpQSVREAISNAYLQLHNTMEESRASwvPNKTGDlSTAGTTASTVIFRKNHI
 .|. . ||||||.|. ||.|.. .|  ..            .. |  | ..  |||..|.|.  . . .|  |   || .  .|   ....||. .. .
sqelslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvd.dlpleaiksaslstdkssldsaes..dnkkaG.ttlngssasvilerert

YVANVGDS
 |.. .|.
ivstasdt

subfamily_PPM1K_pd Subfamily PPM1K 45-279 1.2e-22 73.3 In-house 31-227 (263) alignment
Range on Protein: 45-279
Range on HMM: 31-227/263.0
QAFVGVFDGHGGKEAAKYARENLWSVIQDqsnfLTQDPQSVREAISNAYLQLHNTMEESRASWVPNKtgDLSTAGTTASTVIFRK-NHIYVANVGDSTGI
  .|.|||||.|  ||... ..|  ....    | .  . ... . ||...|.. ..      |...  .| ..||||. ...|. ... .|..|||  |
llyvavfdGhaGsaaadfvhdklekilkr....llekekdleivlknafeeldkklkrylefsvaea..ellssGttatvsllrdGtelvlaslGdsrai

MGvRNpryGEpgepqiiPKLLTKDHKPEDPEEQENIRRLGGEVALSLKGVMRVvwermrvksNGKkeidripfLSVARSLGDFwsysaQSGEYTVSPVPY
.  ||   |.       .| ||.||.||  ||.| |.. || |. .  | ..|         ||.        |...|||||.     .  .| |   | 
lc.rn...Gk.......akkltrdhdPeleeekerikaagGsvewnslgkplv.........ngr........lamtrslGdl.....dlkryGviatPe

VYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISD
   . .| ... |.|| .||. .|..  .. .... 
tkslkvdhaadsflvlitdgisfvvnsqelcdlvrl

PP2C_SIG_SM00331 45-327 4e-11 35.9 In-house 30-215 (217) alignment
Range on Protein: 45-327
Range on HMM: 30-215/217.0
QAFVGVFDGHG-GKEAAKYArENLWSVIQDQSNFLTQDPQSVREAISNAYLQlhntmeesraswvpnktGDLSTAGTTASTVI--FRKNHIYVANVGDST
. .. |.||.| |..|| .. . | .... ...  .  .| ...... .| .                  . .  ..|.   .  |.......||.||| 
rlllvvaDgmGkGlaAaaas.sqlrtalrellsegeelsqalkrlnraiyee.................keekgmfaTlllalydfssgklsyanaGdsr

GIMGVrnprygE------PGEpqiipklltkdhkpedpeeqenirrlggevalslkgvmrvvwermrvksngkkeidripflsvarslgdfWSY------
 ..        .        .                                                                      ..       
pyllr......dgklveilkd......................................................................vegaplGle

---SaqsgeytvspvpyVYDFPLDLNEQKFIVLASDGLWNVMSPSDvvnfISDFDSKGTSGSN-NSSDTNVQRDVVSALIKEALSRWSrkklqADNIAVL
   |             |.   |.|..  ...|..|||....|. .    . ... ..   .. .|..  .... |  |. .|  .        |.|.|.
pevs.............vdirelelekgdllllytDGltearsekg....faeerleeiledlvdseaqelaqkiveellelakgsng.....eDdiTvv

IA
. 
vv

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 47-230 5.7e-18 58.4 In-house 22-187 (292) alignment
Range on Protein: 47-230
Range on HMM: 22-187/292.0
F-VGVFDGHG--GKEAAKYARENLWSVIQDqsnfLTQDPQSVREAISNAYLQLHNTMEESRASwvpnktgDLSTAGTTASTVIFRKN-HIYVANVGDSTG
|   |.||||  |.. |..| ..|   . .    ||.. | . ||. .  |..   .... .            |.|..   . | .  ...||||||  
flaavldGhGvnGdkvaqlaedtlevelle....ltrqlqelsealllrildiaakldkltid.......aresattavvcarvrddralilanvGdsra

IMGvrnpRYGEPGEPQIIPklLTKDHKPEDPEEQENIRRLGGEVA------LSLKGVMRVvWERMrvKSNGKkeidripfLSVARSLGDFWSYS
..|    |     . ..||  |..|||||||.|.. |.| || |          .|  || | |   . .|         |...|.||||  . 
llg....rclggsdyeliP..lsrdhkPedPderarilraGGrveptrvrgwgfrGtarv.wrrr..qqeGd........lalsralGdfhlfe

PP2C_2 Protein phosphatase 2C 49-155 9.4e-06 18.1 Pfam-A 28-134 (212) alignment
Range on Protein: 49-155
Range on HMM: 28-134/212.0
GVFDGHGGKEA----AKYARENLWSVIQDQSNFLTQD-PQSVREAISNAYLQLHNTMEESRASwvpnKTgDLSTAGTTASTVIFRKNHIYVANVGDSTGI
 | ||.|  .     |..| |.. . .... .   ..  . ....|.|..|.. .  .|  |.    .  .|.  .|| . .......|.....||.  .
aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq....qe.elkdyatTlllavitpgeivffqiGDgaiv

MGVRNPRYGEPG
.  |. ..  .|
vrdrdgevqllg

PP2C_2 Protein phosphatase 2C 49-155 9.4e-06 18.1 In-house 28-134 (212) alignment
Range on Protein: 49-155
Range on HMM: 28-134/212.0
GVFDGHGGKEA----AKYARENLWSVIQDQSNFLTQD-PQSVREAISNAYLQLHNTMEESRASwvpnKTgDLSTAGTTASTVIFRKNHIYVANVGDSTGI
 | ||.|  .     |..| |.. . .... .   ..  . ....|.|..|.. .  .|  |.    .  .|.  .|| . .......|.....||.  .
aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq....qe.elkdyatTlllavitpgeivffqiGDgaiv

MGVRNPRYGEPG
.  |. ..  .|
vrdrdgevqllg

subfamily_PPM1G_pd Subfamily PPM1G 117-188 2.9e-11 36.0 In-house 295-355 (473) alignment
Range on Protein: 117-188
Range on HMM: 295-355/473.0
TAGTTASTVIFRKNHIYVANVGDSTGIMGVRnprygepgepqIIPKLLTKDHKPEDPEEQENIRRLGGEVAL
 .||||  .. ......|||.|||  ..                   |  ||||||..|.| |.. ||.|  
dsGttAvvaLlkekklivAnaGDsRcvlsrn...........GkAldlslDHkPeDevEleRiekAGGkvde

subfamily_TAB1_pd Subfamily TAB1 118-266 9.3e-07 20.9 In-house 129-258 (333) alignment
Range on Protein: 118-266
Range on HMM: 129-258/333.0
AGTTASTVIFRKNHIYVANVGDSTGIMGVRNPrygepgEPQIipKLLTKDHKPEDPEEQENIRRLGgevaLSLKGVMRVvwERMrvksNGKKEIDRIPFL
 ||||  ..   |..||||||||  ..  |..      . ..  | | .||. . ..| . ...||    |  . . |.  .|.     .|..  .|  .
gGttAvvalifnnkLyVaNvGdsrAllvkrke......sekv..kqLsvdHttdNedEllRlkdLG....ldieqikrn..krl....gskentRsiGdy

SVARSLGDFWSYSAQSGEYTVSPVPYVYDFPLDlNEQKFIVLASDGLWN
.|     |.  .|. .||  ..    .. .|.| . ..|.|| |||. .
kvkkgykdvdilssakgePviaePdiqgaypid.dityflvlmSdGvyk

subfamily_PP2D1_pd Subfamily PP2D1 132-282 4.1e-08 25.3 In-house 190-307 (492) alignment
Range on Protein: 132-282
Range on HMM: 190-307/492.0
IYVANVGDSTGIMgVRNpryGEPgepqiipKLLTKDHKPEDPEEQENIRRLGGEVALSLKgVMRVvwermrvksNGKkeidripfLSVARSLGDfwsYSA
.|.||.|.   .. .|.   |.        . ||..| |....| . ... |. |  | | . .|         ||         |.. | ||    |  
lyianaGnvqAvL.cre...Gka.......iiLtreHtprnkkERtRvekagsvvvksek.nglv.........nGi........ldttRGLGn...yGd

QSGEYTVSPVPYVYDFPLDlNEQKFIVLASDGLWNVMSPSDVVNFISDFDS
.  . .| | |..   .|| ....|.|||| |||.|.|  .|.. . ..  
pkLkksvipePkttsvkld.eaaqflvlAsnGlWevlseeevlsLvkqtla

subfamily_PPM1G_pd Subfamily PPM1G 217-309 8.7e-10 31.2 In-house 363-449 (473) alignment
Range on Protein: 217-309
Range on HMM: 363-449/473.0
LSVARSLGDfWSYSAQ----SGEYTVSPVPYVYDFPLDlNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSGsnnssdtnVQRDVVSALIKEAL
| ..| ||| ..|  .      |  .| .| .    |  .|..|.|||.||.||||.  .||.|. .  .||.          |  ..| .|. ..|
LnlsRAlGD.haYkkneeLplkeqmisAlPDikvltlt.eedeFlvlAcDGiWnvmesqevvdfvraklkkgees........vlseiveeLlDacl

subfamily_PDP_pd Subfamily PDP 242-314 1.4e-09 30.6 In-house 274-346 (398) alignment
Range on Protein: 242-314
Range on HMM: 274-346/398.0
PYVYDFPLDlNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSGSNN-SSDTNVQRDVVSALIKEALSRWSR
| |   .|  ...||.|||.||||...|...||. .... .| .. ..  .......   |.   ||. .  .|
Pevtshklr.endkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqvveelkerkrklkr

Subfamily Dicty-PPM1L-like 253-329 8.5e-06 17.8 In-house 235-303 (305) alignment
Range on Protein: 253-329
Range on HMM: 235-303/305.0
EQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSGSNNSSDTNvqrDVVSALIKEALSRWSRKklqadNIAVLIAYL
. .|.||| ||||.|.|  |||... .   . .|. .   | |   .. .   .||..| |.      || ..|  |
nDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfn...eisrviveeavkrgsgD.....nitlviikl

PPM_PTC7_motif 258-285 2.5e-08 27.3 In-house 1-29 (51) alignment
Range on Protein: 258-285
Range on HMM: 1-29/51.0
VLASDGLWNVMSPSDVVNFISDFDS-KGT
.|||||||.|.|. ..|... |. | ||.
iLAsDGLWDvlsdqeavdlvrdqlskkgl

DUF3306 Protein of unknown function (DUF3306) 308-380 6.1e-06 13.4 Pfam-A 2-58 (115) alignment
Range on Protein: 308-380
Range on HMM: 2-58/115.0
ALSRWSRKKLQAdniavliaylseeEEEEETGAPPLFDVVSSANEATEVGSKSAVSCSEEADSRQCVaipSIP
 ||||||.||.|             ...||. ...  .... .....|  .... . .|..| . .    ..|
flsRWsrRklaa.............kaaeepaeeaeeeeseeeaaeaeaaaeeeeeeaeledeelle...tlp