Gene PPM1D-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP210_AA protein Get Run
AqueP210_AA_0-124 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1D_pd Subfamily PPM1D 1-124 2e-38 125.2 In-house 40-168 (309) alignment
Range on Protein: 1-124
Range on HMM: 40-168/309.0
VFDGHGGRGAAQYAKSRLFPLLETS----CSHEESVKEAMRSSFLKIHSEMSSVRESWTSTREGYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGP
|||||||. ||..|...|.  ..       |..|.| ||.|..||..|..|  ..|.|. |..|.|||.||||.||... .|||...||||| .|.|. |
vfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkep

-FGKLFPKPITANHRPNNYKECQNIEQLG
   || .|..| .|.|.. .| ..||.||
kekklrakeltkdHkPespeekerieelG

PPM_PTC7 1-124 6.1e-26 84.4 In-house 39-156 (259) alignment
Range on Protein: 1-124
Range on HMM: 39-156/259.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEES--VKEAMRSSFLKIHSEMSSVReswTSTREgYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFG
|||||||| ||.||...| . |. . | ||.  ...|.| |||... .... .   .....   ||||.||.|......|||. |||||  .|. .| . 
vfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks...seant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav

klfpKPITANHRPNNYKECQNIEQLG
    |. |  |.|.| .| . ||..|
....kqltedHkpsnedEreRiegag

PP2Cc_SM00332 1-124 8.1e-26 84.0 In-house 45-164 (274) alignment
Range on Protein: 1-124
Range on HMM: 45-164/274.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEES-----VKEAMRSSFLKIHSEMSSVRESWTSTRegylSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRG
|||||||  .|......|.  |. ... ...     |.||....||....|.    .|.   .    ..||.||.|..|.  .||. |||||  .|.  |
vfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen....alsGstavvallkkedlyvanvGDSravlcrng

PfgklfPKPITANHRPNNYKECQNIEQLG
       .... .|.|.. .| . |.. |
k.....avqlsvdhkpedederkRikkag

PP2C Protein phosphatase 2C 1-124 1.2e-25 83.5 Pfam-A 39-155 (255) alignment
Range on Protein: 1-124
Range on HMM: 39-155/255.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEES--VKEAMRSSFLKiHSEMSSVReswTSTREgYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFG
|||||||| ||.||...| ..|. . | .|.  |..|.|.|||. . ...  .   .....   |.||.||.|......|||. |||||  .|. .. . 
vfdghggreaakyarehleeilkeqksflelekvekalrksfla.dtdeelks...skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak

klfpKPITANHRPNNYKECQNIEQLG
    | .|  |.|.. .| . ||..|
....keltedHkpsdedEreRIeeag

PP2C Protein phosphatase 2C 1-124 1.2e-25 83.5 In-house 39-155 (255) alignment
Range on Protein: 1-124
Range on HMM: 39-155/255.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEES--VKEAMRSSFLKiHSEMSSVReswTSTREgYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFG
|||||||| ||.||...| ..|. . | .|.  |..|.|.|||. . ...  .   .....   |.||.||.|......|||. |||||  .|. .. . 
vfdghggreaakyarehleeilkeqksflelekvekalrksfla.dtdeelks...skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak

klfpKPITANHRPNNYKECQNIEQLG
    | .|  |.|.. .| . ||..|
....keltedHkpsdedEreRIeeag

0034914 PP2C-like 1-124 3.1e-24 78.5 In-house 57-178 (295) alignment
Range on Protein: 1-124
Range on HMM: 57-178/295.0
VFDGHGGRGAAQYAKSRLFPLLET--------SCSHEESVKEAMRSSFLKIHSEMSSVRESwtstrEGYLSTSGTTATVVVLQPTKLYIGNVGDSAGILA
|||||||  ||..|...|. ||          ... .|...||.|..||... |. .  ..     . .|..|||||.|......|||..|||||  .| 
vfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall.....rpelagsGtTavvalirgnklyvanvGDSravll

VRGpfgklFPKPITANHRPNNYKECQNIEQLG
 .|      ....|  |.|.|. | . |...|
rng.....elvqltvdhkpvnelererilsag

subfamily_PPM1G2_pd Subfamily PPM1G2 1-122 4.8e-21 68.0 In-house 57-167 (287) alignment
Range on Protein: 1-122
Range on HMM: 57-167/287.0
VFDGHGGRGAAQYAKSRLFPLLETSCSH-EESVKEAMRSSFLKIHSEMSSVreswTSTREgylSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPfgk
|||||||. .|.|| ..|   ...  |. |........ .||.. .|. .     .....   ...|.||.||... .|||..|.|||  .|...|    
vfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkd....eklkd...esaGstavvvlikeeklyvanaGDsravlsskgn...

lfPKPITANHRPNNYKECQNIEQ
   | .. .|.|.. .| . |..
..vkalsfDhkPqeesekkriia

subfamily_PPM1A_pd Subfamily PPM1A 1-124 6.2e-20 64.7 In-house 47-169 (282) alignment
Range on Protein: 1-124
Range on HMM: 47-169/282.0
VFDGHGGRGAAQYAKSRLFPLLET---------SCSHEESVKEAMRSSFLKIHSEMSSVRESWTSTregylSTSGTTATVVVLQPTKLYIGNVGDSAGIL
|||||.|. .|.|.|. |   . .         . |....||||.|..||........  .. ...       ||.||..|......|.| |.||| ..|
vfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlkta.....dksGsTavtvlvsekhliianlGDsRavl

AVRGpfgklFPKPITANHRPNNYKECQNIEQLG
.  |       .  |  |.|.. || . ||| |
crng.....kaaflteDHkpsrpkEkkRieqAG

subfamily_PPM1E_pd Subfamily PPM1E 1-124 5.3e-19 61.4 In-house 45-156 (265) alignment
Range on Protein: 1-124
Range on HMM: 45-156/265.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEESVKEAMRSSFLKIHSEMSSvreswTSTREGYlsTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFGKL
|||||||  ||.||...|. ||    . .|. .||....| .. ... .     ...||..  .||.|| ||...  .||.. .||| ..|   | . .|
vfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflq.....kaerekl..ksGstavvvliekdqlyvaWlGDsqallvrkgeavql

fpkpiTANHRPNNYKECQNIEQLG
     .  |.|.. .| . ||..|
.....mkpHkPeredEkkRieeag

subfamily_PPM1K_pd Subfamily PPM1K 1-122 7.1e-18 57.7 In-house 36-151 (263) alignment
Range on Protein: 1-122
Range on HMM: 36-151/263.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEESVKEAMRSSFLKIHSEMSSVRESWTSTRegYLSTSGTTATVVVLQ-PTKLYIGNVGDSAGILAVRGPfgk
|||||.|  ||... ..|   |..   .|. ... .. .|.... ....  |   . .   | .|||||||..|.  |.| . ..|||  ||  .|    
vfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaea..ellssGttatvsllrdGtelvlaslGdsrailcrnGk...

lfPKPITANHRPNNYKECQNIEQ
  .| .| .| |.  .| . | .
..akkltrdhdPeleeekerika

0049733 PP2C-like 1-123 8.4e-18 57.8 In-house 31-145 (235) alignment
Range on Protein: 1-123
Range on HMM: 31-145/235.0
VFDGHGGRGAAQYAKSRLFPLLETS--CSHEESVKEAMRSSFLKIHSEMSSVRESWTstregYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPfg
|.|||||  |...| ..|. .|       ......||.|..||...... .  ...       |...||||.|..|.. |||. |||||  .|  .|   
vaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalasp.....elagmgtTavvalldggklyvanvGDsrayllrdgk..

klfPKPITANHRPNNYKECQNIEQL
     ..| .|.|.|  | | |...
...lvqltedhspvnelerqriita

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 1-124 1e-15 50.7 In-house 41-150 (255) alignment
Range on Protein: 1-124
Range on HMM: 41-150/255.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEES-VKEAMRSSFLKIHSEMssvreswtSTREgylSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRgpfgK
.||||||| ||..|  .|. .|.     ...  ..... .. .|.  .        | |       ||||..|..   | || |||||  .|. .    .
lfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi........serp...kfiGttaasvliiedkvyianvGdsrvvlcqk....d

LFPKPITANHRPNNYKECQNIEQLG
   | .. .|.|.. .| . |..||
gtakrlsldhkPseeseekriselG

subfamily_PPM1L_pd Subfamily PPM1L 1-124 6.1e-15 48.2 In-house 40-161 (269) alignment
Range on Protein: 1-124
Range on HMM: 40-161/269.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEESVKEAMR-SSFLKI-HSEMSSVRESWTSTREGYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGpfG
|||||||  ||..||..|   . .   . .. ||     .| |.   |. || |    . .    ..|||| . ..| ..| . ||||| |.|  .   |
vfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGttalialvqesdlivanvGdsrGvlydkr..G

KLFpkPITANHRPNNYKECQNIEQLG
|    |.. .|.|.. || . |.. |
kai..plsfdhkpqqvkerkrikkaG

subfamily_ILKAP_pd Subfamily ILKAP 1-123 1e-13 44.1 In-house 48-172 (293) alignment
Range on Protein: 1-123
Range on HMM: 48-172/293.0
VFDGHGGRGAAQYAKSRLFPLLETS------CSHEESVKEAMRSSFLKIHSEMSSVRESWTSTregylSTSGTTATVVVLQPTKLYIGNVGDSAGILAVR
|||||.|. |...|...|   . .        ..|...| ..  || |  .|. .  .. . .        |.|||||.     ||..|.|||  .|. .
vfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPv.....WkdGstatvvlvldnvlyvanlGdskavlvrk

GPFGK-LFPKPITANHRPNNYKECQNIEQL
 . |. .   ..| .| | .|.| . |.. 
keegdkiasvvLtkdhtpvkyeerkriqka

PPM_PTC7_SpoIIE 1-92 1.5e-13 44.1 In-house 39-120 (230) alignment
Range on Protein: 1-92
Range on HMM: 39-120/230.0
VFDGHGGRGaaQYAKSRLFPLLETSCSHEES-VKEAMRSSFLKIHSEMSSVreswtstregyLSTSGTTATVVVLQPTK--LYIGNVGDSAGILA
..||||||   ..| ..|  .|.. . .. . ..|..| ..|... .. .             |.||.||.|....|..  ||. |.|||  .| 
dvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadlede...........psssgaTavvalidpstgklyvanaGdsppllv

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 1-123 2.4e-13 43.3 In-house 26-144 (292) alignment
Range on Protein: 1-123
Range on HMM: 26-144/292.0
VFDGHG--GRGAAQYAKSRLFPLLETSCSHEESVKEAMRSSFLkihSEMSSVRESWTSTREgylsTSGTTATVVVLQPT-KLYIGNVGDSAGILAVRGPF
|.||||  |.  ||.|...|   |  .  .   . ||.    |   .  . ....   .||     ..|...  . .   .|.. |||||  .|      
vldGhGvnGdkvaqlaedtlevelleltrqlqelsealllril...diaakldkltidare....sattavvcarvrddralilanvGdsrallgrclgg

GKLFPKPITANHRPNNYKECQNIEQL
 .  ..|.. .|.|..  | . | . 
sdyeliPlsrdhkPedPderarilra

subfamily_KAPP-like_pd Subfamily KAPP-like 1-122 6.8e-08 24.8 In-house 39-156 (266) alignment
Range on Protein: 1-122
Range on HMM: 39-156/266.0
VFDGHGGRGAAQYAKsRLFP-LLETSCSHeesvkeAMRSSFLKIHSEMSSVRESWTSTREGYL---STSGTTATVVVLQ----PTKLYIGNVGDSAGILA
||||| |.|||. || .|||  ||           . .    .   ..| . |   .  .  |      |.|||....        | ..|||||. .|.
vfdGhaGkGaadaak.klfpkelekllks......tkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssafls

vRGPfGKLFpkpITANHRPNNYKECQNIEQ
 ||    |.   .. .|. .. .| | | .
.rGn.esle...lskdhkakdpeekqrikd

subfamily_PPM1G_pd Subfamily PPM1G 1-48 9.2e-07 21.2 In-house 52-100 (473) alignment
Range on Protein: 1-48
Range on HMM: 52-100/473.0
VFDGHGGRGAAQYAKSRLFPLLETSCSH-EESVKEAMRSSFLKIHSEMS
|.|||||.  |.|  ..|  ||  . .. |. |..|.. .||.. ... 
vyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklk

PP2C_SIG_SM00331 1-91 1.2e-06 21.3 In-house 35-114 (217) alignment
Range on Protein: 1-91
Range on HMM: 35-114/217.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEESVKEAMRSSFLKIHSEmssvreswtstreGYLSTSGTTATVVVL--QPTKLYIGNVGDSAGIL
|.||.|.  ||. | |.| ..|....|..|....|..     |..|                . ...|... ..  .  ||.. |.|||  .|
vaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee.............keekgmfaTlllalydfssgklsyanaGdsrpyl

subfamily_PPM1H_pd Subfamily PPM1H 23-110 3.4e-08 25.7 In-house 127-202 (404) alignment
Range on Protein: 23-110
Range on HMM: 127-202/404.0
ETSCSHEESVKEAMRSSFLKIHSEMSSVreswtstREGYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFgklfpKPITANHR
| . |.|| |. |. |.||.. . ..         || |  . | || |...   |||. | |||  ||  ..       .|. |.. 
ekeiskeeLviGalesaflemDeqiare.......reayrikGGCtalvalvllgklYvanaGDsRailvrkdei.....iplsadft

subfamily_PDP_pd Subfamily PDP 28-121 3.9e-12 39.0 In-house 111-208 (398) alignment
Range on Protein: 28-121
Range on HMM: 111-208/398.0
HEESVKEAMRSSFLKIHSEMS--SVRES-WTSTRE-GYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFGKLFPKPITANHRPNNYKECQNIE
. |.||||....|||. ...|  .....  .|.||    ..||..|.......|.|.. |.||.. .|.|. . |.   .......  .| .| . |.
evekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRik

subfamily_PPM1G_pd Subfamily PPM1G 62-124 2.7e-08 26.3 In-house 293-350 (473) alignment
Range on Protein: 62-124
Range on HMM: 293-350/473.0
LSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRgpfGKLFpkPITANHRPNNYKECQNIEQLG
 . |||||.|..|.  ||.. |.|||  .|.     ||     .  .|.|.. .| . ||. |
GedsGttAvvaLlkekklivAnaGDsRcvlsrn...GkAl..dlslDHkPeDevEleRiekAG

subfamily_TAB1_pd Subfamily TAB1 65-124 4.4e-09 28.6 In-house 129-186 (333) alignment
Range on Protein: 65-124
Range on HMM: 129-186/333.0
SGTTATVVVLQPTKLYIGNVGDSAGILAVRGPfgKLFPKPITANHRPNNYKECQNIEQLG
 |||| |...   |||. |||||  .|  | .  .   | .  .|  .| .| . ...||
gGttAvvalifnnkLyVaNvGdsrAllvkrke..sekvkqLsvdHttdNedEllRlkdLG