Gene PPM1E in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1E
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP211_AA protein Get Run
AqueP211_AA_140-397 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1E_pd Subfamily PPM1E 141-397 4.6e-117 382.9 In-house 4-264 (265) alignment
Range on Protein: 141-397
Range on HMM: 4-264/265.0
PDFSAFCMKNKRRKMEDRHSICLDINTLYGIkGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGIKVTDERFCST----GFKS
 ..|....||||||||||| .. |.|.|...  ......||.|.|||.| |||.|...|.|....|......||. |.||..|.|||||...    ..||
yevsiaavknkrrkmEDrhvaledlnelfel.kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklks

GSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKKYVIGDAEVSEIELDGTED
||||||.||.. .|||.|.|||||.||||| |||.|.||||.||||..|||.|||||..||.|||||.|||||||||.|.|.||.|.|.|.|.||||.|.
GstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgsee

YLVVACDGIWDVVNEEELTSHLEEYFIKGG-TKSDAAKSLVQFAYSEGSGDNLTAIIVFFDS
||..||||.||||||||.....||.. .|  ..|..||.||. |...|| ||.|...||.|.
ylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfldp

0034914 PP2C-like 141-397 6.2e-72 234.8 In-house 21-292 (295) alignment
Range on Protein: 141-397
Range on HMM: 21-292/295.0
PDFSAFCMKNKRRKMEDRHSICLDINTLYGikgfahDQTFFGVYDGHVGPEAADYSSRHVHHNIIR--------HPSFITDPVLAIKEGIKVTDERFCST
  .........|...||.....|....| .      |...|||.||| | .||.. |.........        ......|.. |...... .||.....
lrvgvasdqGrrksneDavlvvlnllslle......dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellel

GFK------SGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINigvWRVNGNLSVSRAIGDPKDK---------
. .      ||.||||||||| .|||..||||.|.|.|.|..||. . |||..|.|..||..||| |..   .||||.| |.||.||   |         
allrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlklllslllle

KYVIGDAEVSEIELD-GTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFDS
 .|.   .|. .||. .  |.|..|.||.|||...||. ... ... || . ..||. ||..|.. || ||.|...|....
plvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng

subfamily_PPM1G2_pd Subfamily PPM1G2 141-395 2.3e-44 144.5 In-house 19-286 (287) alignment
Range on Protein: 141-395
Range on HMM: 19-286/287.0
PDFSAFCMKNKRRKMEDRHSICLDINTLYGikgfAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVL-AIKEGIKVTDERFCST----GFK
  ... .|.  |..||| | .  .. ...      .. ..|.|.||| | ..| |....... | ...||  . .  ..|.... ||| . .       .
tkvgssamqGyrlnmeDahilenelleksd....dkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkdes

SGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLViniGVWRVNGNLSVSRAIGDPKDKKY---------VIGDAEV
.||||||.||.   |||. .|||.| |  || . ..   |||..|.|..||.||||.|    . ||||||..|||.|| . ||          |    .|
aGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfv...elnrvngnLalsralgDfefkknvkkkpeeqivtavPDv

SEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSG------DNLTAIIVFF
   .||  ...||.||||||||....|.   . | . .| . .. ...|.. . .. |       ||.|..|| .
lvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl

0049733 PP2C-like 142-396 9.8e-55 178.3 In-house 4-234 (235) alignment
Range on Protein: 142-396
Range on HMM: 4-234/235.0
DFSAFCMKNK-RRKMEDRHSIcldintlygikgfahDQTFFGVYDGHVGPEAADYSSRHVHHNIIR--HPSFITDPVLAIKEGIKVTDERFCSTGFK---
...|...... |. .||.. .               ....|.|.||| | .|... |.........  .. ...|.. |... .. ..|...... .   
svgaasdigrvrkvneDavlv...............glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspe

---SGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVinigvwRVNGNLSVSRAIGDPKDKkyvigdAEVSEIELD
   .|.||||||..| .||| .|||| |||.|.| .||. |.|.| .|.|.|||..||| |      ||.| | ..||.||.  |      ..|...||.
lagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk......pdvtvlele

GTEdYLVVACDGIWDVVNEEELTSHLEEyfikgGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFD
  . .|..|.||.|||...||. ..| .      . ..||. ||..|.. |. ||.|...|..|
pgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld

subfamily_PPM1L_pd Subfamily PPM1L 142-395 2.2e-41 134.9 In-house 6-266 (269) alignment
Range on Protein: 142-395
Range on HMM: 6-266/269.0
DFSAFCMKNKRRKMEDRHSICLDINTlygikgfAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHP------SFITDPV---LAIKEGIKVTDERFCST
. ...... .| .||||  |  ||.          ...||.|.||| |  ||...   . ..| ..          | |.     ... |   ||..  .
qvavysvlGrrprmedrfeieedikn.......ktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllek

----GFKSGSTAVVALIRGPMLYVGWVGDSQAYLV-RKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDP--KDKKYVIGDAE
       .|.||..||...  | |  ||||.  |. ..| |. .   ||| .  |..||. |||..   |||||.| |..|||.||   |||. || | .
akraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpd

VSEIELDGTE-DYLVVACDGIWDVVNEEELTSHLEEYFikgGTKSDAAKSLVQFAYSEGSGDNLTAIIVFF
.  ..||  . ..|..|.||.||   .||   .. | .   .     |||||  ..  || ||.| ..| .
iltfdlddhkpeflilasdGlwdtfsneeavrfikerl...kepdfGakslvlesfkrGsvdnitvlvvkl

subfamily_PPM1G_pd Subfamily PPM1G 142-207 7.2e-08 24.8 In-house 20-76 (473) alignment
Range on Protein: 142-207
Range on HMM: 20-76/473.0
DFSAFCMKNKRRKMEDRHSICLDINTlygikgfahDQTFFGVYDGHVGPEAADYSSRHVHHNIIRH
...|  |.  | ..|| |   .|...         | ..|.||||| | | | | .... . .  .
sygasamqGwrvsqEDahncitdlde.........dtslfavyDGHGGkevakyvakklpdllkaq

PP2C Protein phosphatase 2C 143-387 1.8e-60 197.7 Pfam-A 3-254 (255) alignment
Range on Protein: 143-387
Range on HMM: 3-254/255.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD--PVLAIKEGIKV-TDERFCS-----TGF
..| .... |..|||.| .. . .      .   .  ||.|.|||.| |||.| . |..  . . .|| ..     |.....   |||.. |        
vgaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskanteps

KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAV-QIMEPHKPDREDEQQRIEAAGGLVINigVWRVNGNLSVSRAIGDPKDKK----YVIGDAEVSEI
|||||||||||||  ||| .||||.|.|.||. |. ...| |||..||| .|||.||| |.|  ..||||.|.||||.|| . |.    .|. . .|...
ksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsv

ELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDN
.|.  ...|..|.||.|||....|. .  ..   |......||. ||..|.. || ||
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedn

PP2C Protein phosphatase 2C 143-387 1.8e-60 197.7 In-house 3-254 (255) alignment
Range on Protein: 143-387
Range on HMM: 3-254/255.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD--PVLAIKEGIKV-TDERFCS-----TGF
..| .... |..|||.| .. . .      .   .  ||.|.|||.| |||.| . |..  . . .|| ..     |.....   |||.. |        
vgaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskanteps

KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAV-QIMEPHKPDREDEQQRIEAAGGLVINigVWRVNGNLSVSRAIGDPKDKK----YVIGDAEVSEI
|||||||||||||  ||| .||||.|.|.||. |. ...| |||..||| .|||.||| |.|  ..||||.|.||||.|| . |.    .|. . .|...
ksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsv

ELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDN
.|.  ...|..|.||.|||....|. .  ..   |......||. ||..|.. || ||
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedn

PPM_PTC7 143-387 2.6e-59 193.8 In-house 3-258 (259) alignment
Range on Protein: 143-387
Range on HMM: 3-258/259.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD--PVLAIKEGIKV--TDERFCS-----TG
..| .... |..|||.| .. . .      .   .  ||.|.|||.| |||.| . |..  . . .|| ..  .  |.....    |||.. |       
ggasafqgfrksmedahialanless....sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantep

FKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAV-QIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKK------YVIGDAEV
 .||||||||||.|  ||| .||||.|.|.|.| || |  | |||..||| .|||.||| |.|.|..||||.| ||||.|| . |.      .|. . ..
stsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdi

SEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGgTKSDAAKSLVQFAYSEGSGDN
|....|  ...|..|.||.||||...|. .   . . |. ....||. ||..|.. || ||
sstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedn

PPM_PTC7_SpoIIE 143-372 1.6e-27 89.8 In-house 3-222 (230) alignment
Range on Protein: 143-372
Range on HMM: 3-222/230.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEaaDYSSRHVHhNIIRHPSFITDPvlAIKEGIKVTDERF-CSTGFK---SGS
..| .... |..|||.| .. . .      .  .   ..|..||| |..   . ..... ...|  .| . .    .| .. .....   .  .   ||.
ggasaaqgarksmedahispanseks....sggrlalvvgdvdGhGgra..alamgllr.talrelafagle..kpeeilrrlnlalaadledepsssga

TAVVALIRGPM--LYVGWVGDSQAYLVRK-GVavqimephkpdredEQQRIeAAGGLV-INIGVWRVNGNLSVSRAIGDPKDKK---YVIGDAEVSEIEL
|||||||..    ||| ..||| ..|||. |               |  || .||||. . |. .||.|.|.||.|.||   .    .|   .. |..||
TavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepdtsdgel

DGTEDYLVVACDGIWDVVNEEELTSHLEEYFIK---GGTKSDAA
.| ...|..|.||.|||.. .|| ... . . |   .| ..|..
fgkdeflilasdglwdvlspqelvdlvrdelekpaaeglleDDi

subfamily_PPM1D_pd Subfamily PPM1D 144-396 4.4e-29 94.5 In-house 5-308 (309) alignment
Range on Protein: 144-396
Range on HMM: 5-308/309.0
SAFCMKNKRRKMEDRHSICLDINTLYGikgfAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDP----VLAIKEGIKVTDERFC-------S-
.... .  |. |||. .| |. .          ...|..|.||| | ||| . ..|. ..| ..  |....    . ||.|.   | |            
tseadqGgrkymeDvvaivleeeesae....elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpkt

-TGF--KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGV------AVQIMEPHKPDREDEQQRIEAAGGLVINI-GVWRV---------NGN--------
 .|    .|.|| | .||.  |||. ||||.. |  |        | .... |||.  .|..||| .|| | .  || ||         ||.        
ksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPF

LSVSRAIGD-----PKDKKYVIG-DAEVSEIELDGTED-YLVVACDGIWDVVNEEELTSHLEEYFIKGGT----KSDAAKSLVQFAYSEGSG-----DNL
|.|.|..||      | ...|.  . .|.. .||. |. ....| ||.|.|.. |.  | .|..  |. .    ... || ||. | .. .      ||.
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnv

TAIIVFFD
..|.|...
svivvile

PP2Cc_SM00332 146-393 2.1e-65 213.8 In-house 15-274 (274) alignment
Range on Protein: 146-393
Range on HMM: 15-274/274.0
FCMKNKRRKMEDRHSICLDINtlygikgFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD-----PVLAIKEGIKVTDERFCSTGF------
 .|...|..|||.| . .| .         .| .||||.||| |.|.|.. |............. .|     .  |.|.... |||..           
ssmqgwrksmeDahvvvvdlv.......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen

-KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIgvwRVNGNLSVSRAIGDPKDK-------KYVIGDAEV
 .|||||||||...  ||| .||||.|.|.|.| |||. . |||..||| .||..||| |..    ||||.|.||||.|| . |       .|.. . .|
alsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyitaepdv

SEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGG--TKSDAAKSLVQFAYSE-GSGDNLTAIIV
. ..|.  .. |..|.||.|||....|. .....   ||     ..||. |.. |..  || || |...|
kvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv

subfamily_PPM1A_pd Subfamily PPM1A 147-396 1.8e-59 194.4 In-house 18-281 (282) alignment
Range on Protein: 147-396
Range on HMM: 18-281/282.0
CMKNKRRKMEDRHSICLDINTLygikgfaHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSF----------------ITDPVLAIKEGIKVTDERFC
 |.. |..|||.|..  ....|       .|..|| |.||| | |.|.|...|...||... ..                . .  ||. | |. . ..  
smqgwrvemEDahtvvaslgal.......kdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlk

STgFKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVInigVWRVNGNLSVSRAIGDPKDKK---------YVI
..  |||||||..|..   |..  .||| | |.|.| |.   | |||.|..|..|||.||| |.   | ||||.| ||||.|| . |.          |.
ta.dksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeekkaeeqlvs

GDAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFD
...||  || .  .|.||.||||||||...||...  .. . ..   .  ||.||. |...||.|||....|.|.
aepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa

subfamily_ILKAP_pd Subfamily ILKAP 147-362 7.3e-36 116.8 In-house 11-243 (293) alignment
Range on Protein: 147-362
Range on HMM: 11-243/293.0
CMKNKRRKMEDRHSICLDINTL-YGIKGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFiTDP-------VLAIKEGIKVTDERFCST------
. | .| .|.| | |  |...     | .    ....|.||| |. |........|..|... .  .|          .. .  | ||| | ..      
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsakekeikkclvdsfkktdeefLklaskakP

GFKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGV------AVQIMEPHKPDREDEQQRIEAAGGLVINIgvwRVNGNLSVSRAIGDPKDKKY-VIGDAE
 .| ||||.| |.   .|||. .|||.| ||||        .|..   |.| ...|..||. ||| | .    ||.| | |||.||| . |.  ||   .
vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg...rvlGvlevsrsiGdgrfkrlGvistPd

VSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYF
|. .||.  . ..|.||||.|.|.. .|  ..  . .
vkkceLtendlfvvlaCdGLwkvfsadevvkfilkvl

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 148-395 1.7e-48 158.1 In-house 13-253 (255) alignment
Range on Protein: 148-395
Range on HMM: 13-253/255.0
MKNKRRKMEDRHSIcldintlYGIKGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPS-FITDPVLAIKEGIKVTDERFCSTGFKSGSTAVVALIR
|  .|  |||. .|       ||     .|. .. ..||| | .||...| .... .      . ..|| ..|.  | .. ..   .   |.||...|| 
miGrrptmedelvi.......yGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserpkfiGttaasvlii

GPMLYVGWVGDSQAYLV-RKGVAVQIMEPHKPDREDEQQRIEAAGGLVINI-GVWRVNGNLSVSRAIGDPKDKKYVIGDAEVS-EIELDGTEDYLVVACD
. . |.  ||||.. |  ..|.|...   |||  |.|..||...|| |..     ||||.|.||||.||   . .|. | ..| ..|   .. .|..|||
edkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflilacd

GIWDVVNEEELTSHLeeyfIKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFF
||||.. .||  . .    ..     .||. |  .||| || ||.. |.. .
Giwdlisdeeaveiv....agisdpekaaeklrdlayssGstdnisvivikl

Subfamily Dicty-PPM1L-like 148-205 2.1e-07 23.1 In-house 14-63 (305) alignment
Range on Protein: 148-205
Range on HMM: 14-63/305.0
MKNKRRKMEDRHSICLDINTlygikgfAHDQTFFGVYDGHVGPEAADYSSRHVhHNII
 .|.|.. |||.  .. ..        .... .|||.||| |  ||.|. ...  .|.
sansrkyqedrnkvkisles.......sqelslfGvfdGhnGdiaaeyvkkkl.veiv

subfamily_PP2D1_pd Subfamily PP2D1 150-206 1.1e-06 20.6 In-house 10-61 (492) alignment
Range on Protein: 150-206
Range on HMM: 10-61/492.0
NKRRK--MEDRHSICLDintlYGIKgfaHDQTFFGVYDGHVGPEAADYSSRHVHHNIIR
| | |  |||.. .. .    .| .    .. |||.|||. |  ||. .....|. . .
nsrWKskmeDkrtlqdy....fgnd...vnscFfgiyDGynGataAeiaakelhevlle

subfamily_PPM1K_pd Subfamily PPM1K 171-397 1.7e-36 118.7 In-house 24-260 (263) alignment
Range on Protein: 171-397
Range on HMM: 24-260/263.0
IKGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGIKVTDERFCS---------TGFKSGSTAVVALIR-GPMLYVGWVGDSQA
.| .  .  ...|.||| |. |||.   .... . |      |    .|.  .  |... .         .  .||.|| |.|.| |  | .  .|||.|
lkeldpellyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsra

YLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVI--NIGVWRVNGNLSVSRAIGDPKDKKY-VIGDAEVSEIELDGTED-YLVVACDGIWDVVNEEELTS
 | |.| | .. . |.|..|.|..|| |||| |    .|  .||| |...|..|| . |.| || . |  ....| ..| .||.  ||| .|||..||. 
ilcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcd

HLEEyfikGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFDS
 ..          .||..|.. |   || || ||..| . .
lvrl....chdpeeaahalteqalqygsednatavvvplga

PP2C_SIG_SM00331 172-394 1.2e-13 44.2 In-house 24-216 (217) alignment
Range on Protein: 172-394
Range on HMM: 24-216/217.0
KGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGIKVTDERfcSTGFKSGSTAVVALI--RGPMLYVGWVGDSQAYLVRKGVAV
     ..... | ||. .  ||   |. ... .  . |  .... |.|. ... .|.  ..   .. |...||.  ..  |..  .|||  ||.|.|  |
vklnegrlllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklv

QIMEPhkpdredeqqrieaagglvinigvwrvngnlSVSRAIGDPKDKKyvigdAEVSEIELDGtEDYLVVACDGIWDVV-----NEEELTSHLEEYFik
.| .                                  ....|  .. .     ....|.||.  .| |. . ||.....     .||.|.  ||...  
eilkd...............................vegaplGlepevs.....vdirelelek.gdllllytDGltearsekgfaeerleeiledlv..

GGTKSDAAK----SLVQFAYSEGSGDNLTAIIVF
. .. . |.    .|...|  ..  |..| ..|.
dseaqelaqkiveellelakgsngeDdiTvvvvk

subfamily_KAPP-like_pd Subfamily KAPP-like 179-393 5.5e-23 74.3 In-house 35-264 (266) alignment
Range on Protein: 179-393
Range on HMM: 35-264/266.0
TFFGVYDGHVGPEAADYSSRHVHHNIIRHPS---------FITDPVLAIKEGIKVTDERFCSTGFKsGSTAVVALIR----GPMLYVGWVGDSQAYLVRK
..|.|.||| |  ||| ... . ... ..            | |    ... .|  |...    .. |.|| .||.       .| |. |||| |.| | 
alfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeye.GatatlalvwsdGqqrylqvanvGdssaflsrG

GVAVQIMEPHKPDREDEQQRIEAAgGLVINIGVWRVNGnLSVSRAIGDPKDKKYVI---GDAEVSE-IELDGTEDYLVVACDGIWDVVNEEELTSHLEEY
  ....   || . ..|.|||    |. .  .  |.|| | ||||.||   |.  |   ..  ||. | |   ...|.|| ||.|||.. ..    ..  
neslelskdhkakdpeekqrikdd.GitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvksl

FIKGGTKSDAAKSLVQFAY-SEGSGDNLTAIIV
. .. |. . |.||.. |  |  . ||.. |.|
ydqqatedkmasslletaiqsikakdnvsvivv

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 179-313 2.2e-14 46.7 In-house 21-182 (292) alignment
Range on Protein: 179-313
Range on HMM: 21-182/292.0
TF-FGVYDGHV--GPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGI----KVTDERFCSTGFKSGSTAVVALIRGP-MLYVGWVGDSQAYLVR-----K
||   |.|||   | . |...  .. ....       .   |.  .|       |. .  .. ......| | .|    |..  ||||.| | |     .
tflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsd

GVAVQIMEPHKPDREDEQQRIEAAGGLVI--------NIGVWRV------NGNLSVSRAIGD
   . .   |||.  ||..|| .||| |           |  ||      .|.|..|||.||
yeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd

subfamily_PHLPP_pd Subfamily PHLPP 219-395 9.1e-16 50.5 In-house 68-245 (246) alignment
Range on Protein: 219-395
Range on HMM: 68-245/246.0
KEGIKVTDERFCSTGFKSGSTAVVALIRGP--------MLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREdEQQRIEAAGGLVINIGvwRVNGNLSVSRA
|  . |.  .  . | | ||.|.. |||          .| |  ||  ||.|.|.|  ... .... ... | .||  | ... . .  ..|| .. .| 
kntllvaqrklGeaGeklgsaallilirhdkvdPaksfsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitedn..kingviestrl

IGDPKDKKYVIGDAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEeyfiKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFF
.|      .|. . .|.|. |   ...|.|  . .|.|.. .|... .     |      ||| ||. | | | .|......| .
lGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavr....keedplvaAkklvdlaqsygaadsvsvlvvrl

subfamily_PPM1G_pd Subfamily PPM1G 231-397 7.1e-34 110.6 In-house 291-472 (473) alignment
Range on Protein: 231-397
Range on HMM: 291-472/473.0
STGFKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGvwRVNGNLSVSRAIGDPKDKKYVIG--------
. | .||.||||||...  |.|  .||| . | |.|.|... . |||. | |..|||.||| |   |  |||| | .|||.||   ||            
epGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqmis

-DAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGG--TKSDAAKSLVQFAY-----SEGSG-DNLTAIIVFFDS
   ..   .|   ...||.||||||.|.. .|   .... . ||   . |.. . |.  .       .|.| || |.||| ...
AlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk

subfamily_TAB1_pd Subfamily TAB1 235-318 2.3e-10 32.8 In-house 128-214 (333) alignment
Range on Protein: 235-318
Range on HMM: 128-214/333.0
KSGSTAVVALIRGPMLYVGWVGDSQAYLVR---KGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKK
. |.|||||||    |||  ||||.| ||.   .   .|.   |. | ||| .|..  |  . .|   .. |.    |.||| | ||
sgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkk

subfamily_PDP_pd Subfamily PDP 235-315 2e-06 20.2 In-house 151-239 (398) alignment
Range on Protein: 235-315
Range on HMM: 151-239/398.0
KSGSTAVVALIRGPMLYVGWVGDSQAYLVRK---G--VAVQIMEPHKPDREDEQQRIEAAGGLVIN---IGVWRVNGNLSVSRAIGDPK
 ||..|..|||.|  |.|  .||..| | ..   |   ||.. . .  | |.| .||...     .   |   |. |.|  .|| || .
lsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvr

PP2C_2 Protein phosphatase 2C 236-378 7.4e-06 18.4 Pfam-A 97-210 (212) alignment
Range on Protein: 236-378
Range on HMM: 97-210/212.0
SGSTAVVALIRGPMLYVGWVGDSQAYLVR-KGVAVQIMEPHKPDREDEQQRIEAA--GGLVinigvwrvngnlsvsraigdpkdkkyvigdaEVSEIELD
 ..| ..|.|..  ......||. .....  | . .. ||.. . . | ...  .  .. .                               ......|.
yatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...............................rirrlkle

GTeDYLVVACDGIWD-VVNEEELTSHLEEYfIKGGTKSDAAKSLVQF
   | |..  ||..| ...||.....|.|. ..  .. .||..| .|
pg.dalllmTDGvsdslrkeepfrellael.letleeegaaeeLaef

PP2C_2 Protein phosphatase 2C 236-378 7.4e-06 18.4 In-house 97-210 (212) alignment
Range on Protein: 236-378
Range on HMM: 97-210/212.0
SGSTAVVALIRGPMLYVGWVGDSQAYLVR-KGVAVQIMEPHKPDREDEQQRIEAA--GGLVinigvwrvngnlsvsraigdpkdkkyvigdaEVSEIELD
 ..| ..|.|..  ......||. .....  | . .. ||.. . . | ...  .  .. .                               ......|.
yatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...............................rirrlkle

GTeDYLVVACDGIWD-VVNEEELTSHLEEYfIKGGTKSDAAKSLVQF
   | |..  ||..| ...||.....|.|. ..  .. .||..| .|
pg.dalllmTDGvsdslrkeepfrellael.letleeegaaeeLaef

subfamily_PP2D1_pd Subfamily PP2D1 237-363 4.1e-21 68.2 In-house 177-307 (492) alignment
Range on Protein: 237-363
Range on HMM: 177-307/492.0
GSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIG-VWRVNGNLSVSRA---IGDPKDKKYVIGDAEVSEIELD
 ..  | |.   .||.  .|. || |.|.|.|...   | |  . | .|.| ||. | . . . .||| |.. |    .|||| || || . ..  ..||
sngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkld

GTEDYLVVACDGIWDVVNEEELTSHLEEYFI
 .  .||.|  |.|.|..||| .| ... . 
eaaqflvlAsnGlWevlseeevlsLvkqtla

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 249-393 4e-19 61.5 In-house 127-274 (276) alignment
Range on Protein: 249-393
Range on HMM: 127-274/276.0
MLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAgGLVINIGVWRVNGnLSVSRAIGDPKDKKYVI---GDAEVSE-IELDGTEDYLVVACDG
 | |. |||| |.| |   ....   || .  .|.|||    |. .  .  |.|| | ||||.||   |.  |   ..  ||. | |   ...|.|| ||
ylqvanvGdssaflsrGneslelskdhkatdpeekqrikdd.GitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdG

IWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAY-SEGSGDNLTAIIV
.|||.. ..    ..  . .. |. . |.||.. |  |  . ||.. |.|
lwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv

Subfamily Dicty-PPM1L-like 280-396 5.7e-17 54.5 In-house 180-304 (305) alignment
Range on Protein: 280-396
Range on HMM: 180-304/305.0
EDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKKYVIGDAEVSEIELDGT-EDYLVVACDGIWDVVNEEELTSHLEEYF-IKGGTK------SDA
.... ||| ... ..| |  .||. |..|| .||   |..|| . .     .  . ...||.| ||.|.|.. ...  ...|   .|   |       . 
deiririeslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfnei

AKSLVQFAYSEGSGDNLTAIIVFFD
 .  |. |.. ||||| | .|... 
srviveeavkrgsgDnitlviiklk

subfamily_PDP_pd Subfamily PDP 319-374 8.6e-07 21.4 In-house 269-324 (398) alignment
Range on Protein: 319-374
Range on HMM: 269-324/398.0
YVIGDAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKS
|.. . || . .|  .. .||.| ||.||....||  |  .|.. |  .|.. . .
YltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkve

PPM_PTC7_motif 339-387 1.2e-09 31.5 In-house 1-50 (51) alignment
Range on Protein: 339-387
Range on HMM: 1-50/51.0
VVACDGIWDVVNEEELTSHLEEYFIKGGTK-SDAAKSLVQFAYSEGSGDN
. |.||.|||....|. . . .   | |..   ||. ||..| ..|| ||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDn