Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PPM1E_pd | Subfamily PPM1E | 141-397 | 4.6e-117 | 382.9 | In-house | 4-264 (265) | alignment | ||
Range on Protein: 141-397
Range on HMM: 4-264/265.0
PDFSAFCMKNKRRKMEDRHSICLDINTLYGIkGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGIKVTDERFCST----GFKS
..|....||||||||||| .. |.|.|... ......||.|.|||.| |||.|...|.|....|......||. |.||..|.|||||... ..||
yevsiaavknkrrkmEDrhvaledlnelfel.kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklks
GSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKKYVIGDAEVSEIELDGTED
||||||.||.. .|||.|.|||||.||||| |||.|.||||.||||..|||.|||||..||.|||||.|||||||||.|.|.||.|.|.|.|.||||.|.
GstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgsee
YLVVACDGIWDVVNEEELTSHLEEYFIKGG-TKSDAAKSLVQFAYSEGSGDNLTAIIVFFDS
||..||||.||||||||.....||.. .| ..|..||.||. |...|| ||.|...||.|.
ylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfldp
|
|||||||||
0034914 | PP2C-like | 141-397 | 6.2e-72 | 234.8 | In-house | 21-292 (295) | alignment | ||
Range on Protein: 141-397
Range on HMM: 21-292/295.0
PDFSAFCMKNKRRKMEDRHSICLDINTLYGikgfahDQTFFGVYDGHVGPEAADYSSRHVHHNIIR--------HPSFITDPVLAIKEGIKVTDERFCST
.........|...||.....|....| . |...|||.||| | .||.. |......... ......|.. |...... .||.....
lrvgvasdqGrrksneDavlvvlnllslle......dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellel
GFK------SGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINigvWRVNGNLSVSRAIGDPKDK---------
. . ||.||||||||| .|||..||||.|.|.|.|..||. . |||..|.|..||..||| |.. .||||.| |.||.|| |
allrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlklllslllle
KYVIGDAEVSEIELD-GTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFDS
.|. .|. .||. . |.|..|.||.|||...||. ... ... || . ..||. ||..|.. || ||.|...|....
plvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
|
|||||||||
subfamily_PPM1G2_pd | Subfamily PPM1G2 | 141-395 | 2.3e-44 | 144.5 | In-house | 19-286 (287) | alignment | ||
Range on Protein: 141-395
Range on HMM: 19-286/287.0
PDFSAFCMKNKRRKMEDRHSICLDINTLYGikgfAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVL-AIKEGIKVTDERFCST----GFK
... .|. |..||| | . .. ... .. ..|.|.||| | ..| |....... | ...|| . . ..|.... ||| . . .
tkvgssamqGyrlnmeDahilenelleksd....dkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkdes
SGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLViniGVWRVNGNLSVSRAIGDPKDKKY---------VIGDAEV
.||||||.||. |||. .|||.| | || . .. |||..|.|..||.||||.| . ||||||..|||.|| . || | .|
aGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfv...elnrvngnLalsralgDfefkknvkkkpeeqivtavPDv
SEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSG------DNLTAIIVFF
.|| ...||.||||||||....|. . | . .| . .. ...|.. . .. | ||.|..|| .
lvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
|
|||||||||
0049733 | PP2C-like | 142-396 | 9.8e-55 | 178.3 | In-house | 4-234 (235) | alignment | ||
Range on Protein: 142-396
Range on HMM: 4-234/235.0
DFSAFCMKNK-RRKMEDRHSIcldintlygikgfahDQTFFGVYDGHVGPEAADYSSRHVHHNIIR--HPSFITDPVLAIKEGIKVTDERFCSTGFK---
...|...... |. .||.. . ....|.|.||| | .|... |......... .. ...|.. |... .. ..|...... .
svgaasdigrvrkvneDavlv...............glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspe
---SGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVinigvwRVNGNLSVSRAIGDPKDKkyvigdAEVSEIELD
.|.||||||..| .||| .|||| |||.|.| .||. |.|.| .|.|.|||..||| | ||.| | ..||.||. | ..|...||.
lagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk......pdvtvlele
GTEdYLVVACDGIWDVVNEEELTSHLEEyfikgGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFD
. .|..|.||.|||...||. ..| . . ..||. ||..|.. |. ||.|...|..|
pgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld
|
|||||||||
subfamily_PPM1L_pd | Subfamily PPM1L | 142-395 | 2.2e-41 | 134.9 | In-house | 6-266 (269) | alignment | ||
Range on Protein: 142-395
Range on HMM: 6-266/269.0
DFSAFCMKNKRRKMEDRHSICLDINTlygikgfAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHP------SFITDPV---LAIKEGIKVTDERFCST
. ...... .| .|||| | ||. ...||.|.||| | ||... . ..| .. | |. ... | ||.. .
qvavysvlGrrprmedrfeieedikn.......ktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllek
----GFKSGSTAVVALIRGPMLYVGWVGDSQAYLV-RKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDP--KDKKYVIGDAE
.|.||..||... | | ||||. |. ..| |. . ||| . |..||. |||.. |||||.| |..|||.|| |||. || | .
akraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpd
VSEIELDGTE-DYLVVACDGIWDVVNEEELTSHLEEYFikgGTKSDAAKSLVQFAYSEGSGDNLTAIIVFF
. ..|| . ..|..|.||.|| .|| .. | . . ||||| .. || ||.| ..| .
iltfdlddhkpeflilasdGlwdtfsneeavrfikerl...kepdfGakslvlesfkrGsvdnitvlvvkl
|
|||||||||
subfamily_PPM1G_pd | Subfamily PPM1G | 142-207 | 7.2e-08 | 24.8 | In-house | 20-76 (473) | alignment | ||
Range on Protein: 142-207
Range on HMM: 20-76/473.0
DFSAFCMKNKRRKMEDRHSICLDINTlygikgfahDQTFFGVYDGHVGPEAADYSSRHVHHNIIRH
...| |. | ..|| | .|... | ..|.||||| | | | | .... . . .
sygasamqGwrvsqEDahncitdlde.........dtslfavyDGHGGkevakyvakklpdllkaq
|
|||||||||
PP2C | Protein phosphatase 2C | 143-387 | 1.8e-60 | 197.7 | Pfam-A | 3-254 (255) | alignment | ||
Range on Protein: 143-387
Range on HMM: 3-254/255.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD--PVLAIKEGIKV-TDERFCS-----TGF
..| .... |..|||.| .. . . . . ||.|.|||.| |||.| . |.. . . .|| .. |..... |||.. |
vgaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskanteps
KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAV-QIMEPHKPDREDEQQRIEAAGGLVINigVWRVNGNLSVSRAIGDPKDKK----YVIGDAEVSEI
||||||||||||| ||| .||||.|.|.||. |. ...| |||..||| .|||.||| |.| ..||||.|.||||.|| . |. .|. . .|...
ksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsv
ELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDN
.|. ...|..|.||.|||....|. . .. |......||. ||..|.. || ||
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedn
|
|||||||||
PP2C | Protein phosphatase 2C | 143-387 | 1.8e-60 | 197.7 | In-house | 3-254 (255) | alignment | ||
Range on Protein: 143-387
Range on HMM: 3-254/255.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD--PVLAIKEGIKV-TDERFCS-----TGF
..| .... |..|||.| .. . . . . ||.|.|||.| |||.| . |.. . . .|| .. |..... |||.. |
vgaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskanteps
KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAV-QIMEPHKPDREDEQQRIEAAGGLVINigVWRVNGNLSVSRAIGDPKDKK----YVIGDAEVSEI
||||||||||||| ||| .||||.|.|.||. |. ...| |||..||| .|||.||| |.| ..||||.|.||||.|| . |. .|. . .|...
ksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsv
ELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDN
.|. ...|..|.||.|||....|. . .. |......||. ||..|.. || ||
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedn
|
|||||||||
PPM_PTC7 | 143-387 | 2.6e-59 | 193.8 | In-house | 3-258 (259) | alignment | |||
Range on Protein: 143-387
Range on HMM: 3-258/259.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD--PVLAIKEGIKV--TDERFCS-----TG
..| .... |..|||.| .. . . . . ||.|.|||.| |||.| . |.. . . .|| .. . |..... |||.. |
ggasafqgfrksmedahialanless....sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantep
FKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAV-QIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKK------YVIGDAEV
.||||||||||.| ||| .||||.|.|.|.| || | | |||..||| .|||.||| |.|.|..||||.| ||||.|| . |. .|. . ..
stsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdi
SEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGgTKSDAAKSLVQFAYSEGSGDN
|....| ...|..|.||.||||...|. . . . |. ....||. ||..|.. || ||
sstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedn
|
|||||||||
PPM_PTC7_SpoIIE | 143-372 | 1.6e-27 | 89.8 | In-house | 3-222 (230) | alignment | |||
Range on Protein: 143-372
Range on HMM: 3-222/230.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEaaDYSSRHVHhNIIRHPSFITDPvlAIKEGIKVTDERF-CSTGFK---SGS
..| .... |..|||.| .. . . . . ..|..||| |.. . ..... ...| .| . . .| .. ..... . . ||.
ggasaaqgarksmedahispanseks....sggrlalvvgdvdGhGgra..alamgllr.talrelafagle..kpeeilrrlnlalaadledepsssga
TAVVALIRGPM--LYVGWVGDSQAYLVRK-GVavqimephkpdredEQQRIeAAGGLV-INIGVWRVNGNLSVSRAIGDPKDKK---YVIGDAEVSEIEL
|||||||.. ||| ..||| ..|||. | | || .||||. . |. .||.|.|.||.|.|| . .| .. |..||
TavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepdtsdgel
DGTEDYLVVACDGIWDVVNEEELTSHLEEYFIK---GGTKSDAA
.| ...|..|.||.|||.. .|| ... . . | .| ..|..
fgkdeflilasdglwdvlspqelvdlvrdelekpaaeglleDDi
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 144-396 | 4.4e-29 | 94.5 | In-house | 5-308 (309) | alignment | ||
Range on Protein: 144-396
Range on HMM: 5-308/309.0
SAFCMKNKRRKMEDRHSICLDINTLYGikgfAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDP----VLAIKEGIKVTDERFC-------S-
.... . |. |||. .| |. . ...|..|.||| | ||| . ..|. ..| .. |.... . ||.|. | |
tseadqGgrkymeDvvaivleeeesae....elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpkt
-TGF--KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGV------AVQIMEPHKPDREDEQQRIEAAGGLVINI-GVWRV---------NGN--------
.| .|.|| | .||. |||. ||||.. | | | .... |||. .|..||| .|| | . || || ||.
ksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPF
LSVSRAIGD-----PKDKKYVIG-DAEVSEIELDGTED-YLVVACDGIWDVVNEEELTSHLEEYFIKGGT----KSDAAKSLVQFAYSEGSG-----DNL
|.|.|..|| | ...|. . .|.. .||. |. ....| ||.|.|.. |. | .|.. |. . ... || ||. | .. . ||.
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnv
TAIIVFFD
..|.|...
svivvile
|
|||||||||
PP2Cc_SM00332 | 146-393 | 2.1e-65 | 213.8 | In-house | 15-274 (274) | alignment | |||
Range on Protein: 146-393
Range on HMM: 15-274/274.0
FCMKNKRRKMEDRHSICLDINtlygikgFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD-----PVLAIKEGIKVTDERFCSTGF------
.|...|..|||.| . .| . .| .||||.||| |.|.|.. |............. .| . |.|.... |||..
ssmqgwrksmeDahvvvvdlv.......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen
-KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIgvwRVNGNLSVSRAIGDPKDK-------KYVIGDAEV
.|||||||||... ||| .||||.|.|.|.| |||. . |||..||| .||..||| |.. ||||.|.||||.|| . | .|.. . .|
alsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyitaepdv
SEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGG--TKSDAAKSLVQFAYSE-GSGDNLTAIIV
. ..|. .. |..|.||.|||....|. ..... || ..||. |.. |.. || || |...|
kvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
|
|||||||||
subfamily_PPM1A_pd | Subfamily PPM1A | 147-396 | 1.8e-59 | 194.4 | In-house | 18-281 (282) | alignment | ||
Range on Protein: 147-396
Range on HMM: 18-281/282.0
CMKNKRRKMEDRHSICLDINTLygikgfaHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSF----------------ITDPVLAIKEGIKVTDERFC
|.. |..|||.|.. ....| .|..|| |.||| | |.|.|...|...||... .. . . ||. | |. . ..
smqgwrvemEDahtvvaslgal.......kdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlk
STgFKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVInigVWRVNGNLSVSRAIGDPKDKK---------YVI
.. |||||||..|.. |.. .||| | |.|.| |. | |||.|..|..|||.||| |. | ||||.| ||||.|| . |. |.
ta.dksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeekkaeeqlvs
GDAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFD
...|| || . .|.||.||||||||...||... .. . .. . ||.||. |...||.|||....|.|.
aepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
|
|||||||||
subfamily_ILKAP_pd | Subfamily ILKAP | 147-362 | 7.3e-36 | 116.8 | In-house | 11-243 (293) | alignment | ||
Range on Protein: 147-362
Range on HMM: 11-243/293.0
CMKNKRRKMEDRHSICLDINTL-YGIKGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFiTDP-------VLAIKEGIKVTDERFCST------
. | .| .|.| | | |... | . ....|.||| |. |........|..|... . .| .. . | ||| | ..
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsakekeikkclvdsfkktdeefLklaskakP
GFKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGV------AVQIMEPHKPDREDEQQRIEAAGGLVINIgvwRVNGNLSVSRAIGDPKDKKY-VIGDAE
.| ||||.| |. .|||. .|||.| |||| .|.. |.| ...|..||. ||| | . ||.| | |||.||| . |. || .
vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg...rvlGvlevsrsiGdgrfkrlGvistPd
VSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYF
|. .||. . ..|.||||.|.|.. .| .. . .
vkkceLtendlfvvlaCdGLwkvfsadevvkfilkvl
|
|||||||||
subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 148-395 | 1.7e-48 | 158.1 | In-house | 13-253 (255) | alignment | ||
Range on Protein: 148-395
Range on HMM: 13-253/255.0
MKNKRRKMEDRHSIcldintlYGIKGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPS-FITDPVLAIKEGIKVTDERFCSTGFKSGSTAVVALIR
| .| |||. .| || .|. .. ..||| | .||...| .... . . ..|| ..|. | .. .. . |.||...||
miGrrptmedelvi.......yGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserpkfiGttaasvlii
GPMLYVGWVGDSQAYLV-RKGVAVQIMEPHKPDREDEQQRIEAAGGLVINI-GVWRVNGNLSVSRAIGDPKDKKYVIGDAEVS-EIELDGTEDYLVVACD
. . |. ||||.. | ..|.|... ||| |.|..||...|| |.. ||||.|.||||.|| . .|. | ..| ..| .. .|..|||
edkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflilacd
GIWDVVNEEELTSHLeeyfIKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFF
||||.. .|| . . .. .||. | .||| || ||.. |.. .
Giwdlisdeeaveiv....agisdpekaaeklrdlayssGstdnisvivikl
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 148-205 | 2.1e-07 | 23.1 | In-house | 14-63 (305) | alignment | ||
Range on Protein: 148-205
Range on HMM: 14-63/305.0
MKNKRRKMEDRHSICLDINTlygikgfAHDQTFFGVYDGHVGPEAADYSSRHVhHNII
.|.|.. |||. .. .. .... .|||.||| | ||.|. ... .|.
sansrkyqedrnkvkisles.......sqelslfGvfdGhnGdiaaeyvkkkl.veiv
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 150-206 | 1.1e-06 | 20.6 | In-house | 10-61 (492) | alignment | ||
Range on Protein: 150-206
Range on HMM: 10-61/492.0
NKRRK--MEDRHSICLDintlYGIKgfaHDQTFFGVYDGHVGPEAADYSSRHVHHNIIR
| | | |||.. .. . .| . .. |||.|||. | ||. .....|. . .
nsrWKskmeDkrtlqdy....fgnd...vnscFfgiyDGynGataAeiaakelhevlle
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 171-397 | 1.7e-36 | 118.7 | In-house | 24-260 (263) | alignment | ||
Range on Protein: 171-397
Range on HMM: 24-260/263.0
IKGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGIKVTDERFCS---------TGFKSGSTAVVALIR-GPMLYVGWVGDSQA
.| . . ...|.||| |. |||. .... . | | .|. . |... . . .||.|| |.|.| | | . .|||.|
lkeldpellyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsra
YLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVI--NIGVWRVNGNLSVSRAIGDPKDKKY-VIGDAEVSEIELDGTED-YLVVACDGIWDVVNEEELTS
| |.| | .. . |.|..|.|..|| |||| | .| .||| |...|..|| . |.| || . | ....| ..| .||. ||| .|||..||.
ilcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcd
HLEEyfikGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFDS
.. .||..|.. | || || ||..| . .
lvrl....chdpeeaahalteqalqygsednatavvvplga
|
|||||||||
PP2C_SIG_SM00331 | 172-394 | 1.2e-13 | 44.2 | In-house | 24-216 (217) | alignment | |||
Range on Protein: 172-394
Range on HMM: 24-216/217.0
KGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGIKVTDERfcSTGFKSGSTAVVALI--RGPMLYVGWVGDSQAYLVRKGVAV
..... | ||. . || |. ... . . | .... |.|. ... .|. .. .. |...||. .. |.. .||| ||.|.| |
vklnegrlllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklv
QIMEPhkpdredeqqrieaagglvinigvwrvngnlSVSRAIGDPKDKKyvigdAEVSEIELDGtEDYLVVACDGIWDVV-----NEEELTSHLEEYFik
.| . ....| .. . ....|.||. .| |. . ||..... .||.|. ||...
eilkd...............................vegaplGlepevs.....vdirelelek.gdllllytDGltearsekgfaeerleeiledlv..
GGTKSDAAK----SLVQFAYSEGSGDNLTAIIVF
. .. . |. .|...| .. |..| ..|.
dseaqelaqkiveellelakgsngeDdiTvvvvk
|
|||||||||
subfamily_KAPP-like_pd | Subfamily KAPP-like | 179-393 | 5.5e-23 | 74.3 | In-house | 35-264 (266) | alignment | ||
Range on Protein: 179-393
Range on HMM: 35-264/266.0
TFFGVYDGHVGPEAADYSSRHVHHNIIRHPS---------FITDPVLAIKEGIKVTDERFCSTGFKsGSTAVVALIR----GPMLYVGWVGDSQAYLVRK
..|.|.||| | ||| ... . ... .. | | ... .| |... .. |.|| .||. .| |. |||| |.| |
alfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeye.GatatlalvwsdGqqrylqvanvGdssaflsrG
GVAVQIMEPHKPDREDEQQRIEAAgGLVINIGVWRVNGnLSVSRAIGDPKDKKYVI---GDAEVSE-IELDGTEDYLVVACDGIWDVVNEEELTSHLEEY
.... || . ..|.||| |. . . |.|| | ||||.|| |. | .. ||. | | ...|.|| ||.|||.. .. ..
neslelskdhkakdpeekqrikdd.GitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvksl
FIKGGTKSDAAKSLVQFAY-SEGSGDNLTAIIV
. .. |. . |.||.. | | . ||.. |.|
ydqqatedkmasslletaiqsikakdnvsvivv
|
|||||||||
subfamily_Choan-PPM1K-like_pd | Subfamily Choan-PPM1K-like | 179-313 | 2.2e-14 | 46.7 | In-house | 21-182 (292) | alignment | ||
Range on Protein: 179-313
Range on HMM: 21-182/292.0
TF-FGVYDGHV--GPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGI----KVTDERFCSTGFKSGSTAVVALIRGP-MLYVGWVGDSQAYLVR-----K
|| |.||| | . |... .. .... . |. .| |. . .. ......| | .| |.. ||||.| | | .
tflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsd
GVAVQIMEPHKPDREDEQQRIEAAGGLVI--------NIGVWRV------NGNLSVSRAIGD
. . |||. ||..|| .||| | | || .|.|..|||.||
yeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd
|
|||||||||
subfamily_PHLPP_pd | Subfamily PHLPP | 219-395 | 9.1e-16 | 50.5 | In-house | 68-245 (246) | alignment | ||
Range on Protein: 219-395
Range on HMM: 68-245/246.0
KEGIKVTDERFCSTGFKSGSTAVVALIRGP--------MLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREdEQQRIEAAGGLVINIGvwRVNGNLSVSRA
| . |. . . | | ||.|.. ||| .| | || ||.|.|.| ... .... ... | .|| | ... . . ..|| .. .|
kntllvaqrklGeaGeklgsaallilirhdkvdPaksfsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitedn..kingviestrl
IGDPKDKKYVIGDAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEeyfiKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFF
.| .|. . .|.|. | ...|.| . .|.|.. .|... . | ||| ||. | | | .|......| .
lGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavr....keedplvaAkklvdlaqsygaadsvsvlvvrl
|
|||||||||
subfamily_PPM1G_pd | Subfamily PPM1G | 231-397 | 7.1e-34 | 110.6 | In-house | 291-472 (473) | alignment | ||
Range on Protein: 231-397
Range on HMM: 291-472/473.0
STGFKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGvwRVNGNLSVSRAIGDPKDKKYVIG--------
. | .||.||||||... |.| .||| . | |.|.|... . |||. | |..|||.||| | | |||| | .|||.|| ||
epGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqmis
-DAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGG--TKSDAAKSLVQFAY-----SEGSG-DNLTAIIVFFDS
.. .| ...||.||||||.|.. .| .... . || . |.. . |. . .|.| || |.||| ...
AlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
|
|||||||||
subfamily_TAB1_pd | Subfamily TAB1 | 235-318 | 2.3e-10 | 32.8 | In-house | 128-214 (333) | alignment | ||
Range on Protein: 235-318
Range on HMM: 128-214/333.0
KSGSTAVVALIRGPMLYVGWVGDSQAYLVR---KGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKK
. |.||||||| ||| ||||.| ||. . .|. |. | ||| .|.. | . .| .. |. |.||| | ||
sgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkk
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 235-315 | 2e-06 | 20.2 | In-house | 151-239 (398) | alignment | ||
Range on Protein: 235-315
Range on HMM: 151-239/398.0
KSGSTAVVALIRGPMLYVGWVGDSQAYLVRK---G--VAVQIMEPHKPDREDEQQRIEAAGGLVIN---IGVWRVNGNLSVSRAIGDPK
||..|..|||.| |.| .||..| | .. | ||.. . . | |.| .||... . | |. |.| .|| || .
lsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvr
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 236-378 | 7.4e-06 | 18.4 | Pfam-A | 97-210 (212) | alignment | ||
Range on Protein: 236-378
Range on HMM: 97-210/212.0
SGSTAVVALIRGPMLYVGWVGDSQAYLVR-KGVAVQIMEPHKPDREDEQQRIEAA--GGLVinigvwrvngnlsvsraigdpkdkkyvigdaEVSEIELD
..| ..|.|.. ......||. ..... | . .. ||.. . . | ... . .. . ......|.
yatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...............................rirrlkle
GTeDYLVVACDGIWD-VVNEEELTSHLEEYfIKGGTKSDAAKSLVQF
| |.. ||..| ...||.....|.|. .. .. .||..| .|
pg.dalllmTDGvsdslrkeepfrellael.letleeegaaeeLaef
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 236-378 | 7.4e-06 | 18.4 | In-house | 97-210 (212) | alignment | ||
Range on Protein: 236-378
Range on HMM: 97-210/212.0
SGSTAVVALIRGPMLYVGWVGDSQAYLVR-KGVAVQIMEPHKPDREDEQQRIEAA--GGLVinigvwrvngnlsvsraigdpkdkkyvigdaEVSEIELD
..| ..|.|.. ......||. ..... | . .. ||.. . . | ... . .. . ......|.
yatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...............................rirrlkle
GTeDYLVVACDGIWD-VVNEEELTSHLEEYfIKGGTKSDAAKSLVQF
| |.. ||..| ...||.....|.|. .. .. .||..| .|
pg.dalllmTDGvsdslrkeepfrellael.letleeegaaeeLaef
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 237-363 | 4.1e-21 | 68.2 | In-house | 177-307 (492) | alignment | ||
Range on Protein: 237-363
Range on HMM: 177-307/492.0
GSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIG-VWRVNGNLSVSRA---IGDPKDKKYVIGDAEVSEIELD
.. | |. .||. .|. || |.|.|.|... | | . | .|.| ||. | . . . .||| |.. | .|||| || || . .. ..||
sngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkld
GTEDYLVVACDGIWDVVNEEELTSHLEEYFI
. .||.| |.|.|..||| .| ... .
eaaqflvlAsnGlWevlseeevlsLvkqtla
|
|||||||||
subfamily_Dicty-PPM-1_pd | Subfamily Dicty-PPM-1 | 249-393 | 4e-19 | 61.5 | In-house | 127-274 (276) | alignment | ||
Range on Protein: 249-393
Range on HMM: 127-274/276.0
MLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAgGLVINIGVWRVNGnLSVSRAIGDPKDKKYVI---GDAEVSE-IELDGTEDYLVVACDG
| |. |||| |.| | .... || . .|.||| |. . . |.|| | ||||.|| |. | .. ||. | | ...|.|| ||
ylqvanvGdssaflsrGneslelskdhkatdpeekqrikdd.GitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdG
IWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAY-SEGSGDNLTAIIV
.|||.. .. .. . .. |. . |.||.. | | . ||.. |.|
lwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 280-396 | 5.7e-17 | 54.5 | In-house | 180-304 (305) | alignment | ||
Range on Protein: 280-396
Range on HMM: 180-304/305.0
EDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKKYVIGDAEVSEIELDGT-EDYLVVACDGIWDVVNEEELTSHLEEYF-IKGGTK------SDA
.... ||| ... ..| | .||. |..|| .|| |..|| . . . . ...||.| ||.|.|.. ... ...| .| | .
deiririeslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfnei
AKSLVQFAYSEGSGDNLTAIIVFFD
. |. |.. ||||| | .|...
srviveeavkrgsgDnitlviiklk
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 319-374 | 8.6e-07 | 21.4 | In-house | 269-324 (398) | alignment | ||
Range on Protein: 319-374
Range on HMM: 269-324/398.0
YVIGDAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKS
|.. . || . .| .. .||.| ||.||....|| | .|.. | .|.. . .
YltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkve
|
|||||||||
PPM_PTC7_motif | 339-387 | 1.2e-09 | 31.5 | In-house | 1-50 (51) | alignment | |||
Range on Protein: 339-387
Range on HMM: 1-50/51.0
VVACDGIWDVVNEEELTSHLEEYFIKGGTK-SDAAKSLVQFAYSEGSGDN
. |.||.|||....|. . . . | |.. ||. ||..| ..|| ||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDn
|