Gene PPM1E in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1E
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP211_AA protein Get Run
AqueP211_AA_140-397 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1E_pd Subfamily PPM1E 141-397 4.6e-117 382.9 In-house 4-264 (265) alignment 
Range on Protein: 141-397
Range on HMM: 4-264/265.0
PDFSAFCMKNKRRKMEDRHSICLDINTLYGIkGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGIKVTDERFCST----GFKS
 ..|....||||||||||| .. |.|.|...  ......||.|.|||.| |||.|...|.|....|......||. |.||..|.|||||...    ..||
yevsiaavknkrrkmEDrhvaledlnelfel.kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklks

GSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKKYVIGDAEVSEIELDGTED
||||||.||.. .|||.|.|||||.||||| |||.|.||||.||||..|||.|||||..||.|||||.|||||||||.|.|.||.|.|.|.|.||||.|.
GstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgsee

YLVVACDGIWDVVNEEELTSHLEEYFIKGG-TKSDAAKSLVQFAYSEGSGDNLTAIIVFFDS
||..||||.||||||||.....||.. .|  ..|..||.||. |...|| ||.|...||.|.
ylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfldp
0034914 PP2C-like 141-397 6.2e-72 234.8 In-house 21-292 (295) alignment 
Range on Protein: 141-397
Range on HMM: 21-292/295.0
PDFSAFCMKNKRRKMEDRHSICLDINTLYGikgfahDQTFFGVYDGHVGPEAADYSSRHVHHNIIR--------HPSFITDPVLAIKEGIKVTDERFCST
  .........|...||.....|....| .      |...|||.||| | .||.. |.........        ......|.. |...... .||.....
lrvgvasdqGrrksneDavlvvlnllslle......dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellel

GFK------SGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINigvWRVNGNLSVSRAIGDPKDK---------
. .      ||.||||||||| .|||..||||.|.|.|.|..||. . |||..|.|..||..||| |..   .||||.| |.||.||   |         
allrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlklllslllle

KYVIGDAEVSEIELD-GTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFDS
 .|.   .|. .||. .  |.|..|.||.|||...||. ... ... || . ..||. ||..|.. || ||.|...|....
plvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
subfamily_PPM1G2_pd Subfamily PPM1G2 141-395 2.3e-44 144.5 In-house 19-286 (287) alignment 
Range on Protein: 141-395
Range on HMM: 19-286/287.0
PDFSAFCMKNKRRKMEDRHSICLDINTLYGikgfAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVL-AIKEGIKVTDERFCST----GFK
  ... .|.  |..||| | .  .. ...      .. ..|.|.||| | ..| |....... | ...||  . .  ..|.... ||| . .       .
tkvgssamqGyrlnmeDahilenelleksd....dkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkdes

SGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLViniGVWRVNGNLSVSRAIGDPKDKKY---------VIGDAEV
.||||||.||.   |||. .|||.| |  || . ..   |||..|.|..||.||||.|    . ||||||..|||.|| . ||          |    .|
aGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfv...elnrvngnLalsralgDfefkknvkkkpeeqivtavPDv

SEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSG------DNLTAIIVFF
   .||  ...||.||||||||....|.   . | . .| . .. ...|.. . .. |       ||.|..|| .
lvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
0049733 PP2C-like 142-396 9.8e-55 178.3 In-house 4-234 (235) alignment 
Range on Protein: 142-396
Range on HMM: 4-234/235.0
DFSAFCMKNK-RRKMEDRHSIcldintlygikgfahDQTFFGVYDGHVGPEAADYSSRHVHHNIIR--HPSFITDPVLAIKEGIKVTDERFCSTGFK---
...|...... |. .||.. .               ....|.|.||| | .|... |.........  .. ...|.. |... .. ..|...... .   
svgaasdigrvrkvneDavlv...............glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspe

---SGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVinigvwRVNGNLSVSRAIGDPKDKkyvigdAEVSEIELD
   .|.||||||..| .||| .|||| |||.|.| .||. |.|.| .|.|.|||..||| |      ||.| | ..||.||.  |      ..|...||.
lagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk......pdvtvlele

GTEdYLVVACDGIWDVVNEEELTSHLEEyfikgGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFD
  . .|..|.||.|||...||. ..| .      . ..||. ||..|.. |. ||.|...|..|
pgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_PPM1L_pd Subfamily PPM1L 142-395 2.2e-41 134.9 In-house 6-266 (269) alignment 
Range on Protein: 142-395
Range on HMM: 6-266/269.0
DFSAFCMKNKRRKMEDRHSICLDINTlygikgfAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHP------SFITDPV---LAIKEGIKVTDERFCST
. ...... .| .||||  |  ||.          ...||.|.||| |  ||...   . ..| ..          | |.     ... |   ||..  .
qvavysvlGrrprmedrfeieedikn.......ktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllek

----GFKSGSTAVVALIRGPMLYVGWVGDSQAYLV-RKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDP--KDKKYVIGDAE
       .|.||..||...  | |  ||||.  |. ..| |. .   ||| .  |..||. |||..   |||||.| |..|||.||   |||. || | .
akraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpd

VSEIELDGTE-DYLVVACDGIWDVVNEEELTSHLEEYFikgGTKSDAAKSLVQFAYSEGSGDNLTAIIVFF
.  ..||  . ..|..|.||.||   .||   .. | .   .     |||||  ..  || ||.| ..| .
iltfdlddhkpeflilasdGlwdtfsneeavrfikerl...kepdfGakslvlesfkrGsvdnitvlvvkl
subfamily_PPM1G_pd Subfamily PPM1G 142-207 7.2e-08 24.8 In-house 20-76 (473) alignment 
Range on Protein: 142-207
Range on HMM: 20-76/473.0
DFSAFCMKNKRRKMEDRHSICLDINTlygikgfahDQTFFGVYDGHVGPEAADYSSRHVHHNIIRH
...|  |.  | ..|| |   .|...         | ..|.||||| | | | | .... . .  .
sygasamqGwrvsqEDahncitdlde.........dtslfavyDGHGGkevakyvakklpdllkaq
PP2C Protein phosphatase 2C 143-387 1.8e-60 197.7 Pfam-A 3-254 (255) alignment 
Range on Protein: 143-387
Range on HMM: 3-254/255.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD--PVLAIKEGIKV-TDERFCS-----TGF
..| .... |..|||.| .. . .      .   .  ||.|.|||.| |||.| . |..  . . .|| ..     |.....   |||.. |        
vgaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskanteps

KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAV-QIMEPHKPDREDEQQRIEAAGGLVINigVWRVNGNLSVSRAIGDPKDKK----YVIGDAEVSEI
|||||||||||||  ||| .||||.|.|.||. |. ...| |||..||| .|||.||| |.|  ..||||.|.||||.|| . |.    .|. . .|...
ksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsv

ELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDN
.|.  ...|..|.||.|||....|. .  ..   |......||. ||..|.. || ||
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedn
PP2C Protein phosphatase 2C 143-387 1.8e-60 197.7 In-house 3-254 (255) alignment 
Range on Protein: 143-387
Range on HMM: 3-254/255.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD--PVLAIKEGIKV-TDERFCS-----TGF
..| .... |..|||.| .. . .      .   .  ||.|.|||.| |||.| . |..  . . .|| ..     |.....   |||.. |        
vgaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskanteps

KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAV-QIMEPHKPDREDEQQRIEAAGGLVINigVWRVNGNLSVSRAIGDPKDKK----YVIGDAEVSEI
|||||||||||||  ||| .||||.|.|.||. |. ...| |||..||| .|||.||| |.|  ..||||.|.||||.|| . |.    .|. . .|...
ksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsv

ELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDN
.|.  ...|..|.||.|||....|. .  ..   |......||. ||..|.. || ||
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedn
PPM_PTC7 143-387 2.6e-59 193.8 In-house 3-258 (259) alignment 
Range on Protein: 143-387
Range on HMM: 3-258/259.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD--PVLAIKEGIKV--TDERFCS-----TG
..| .... |..|||.| .. . .      .   .  ||.|.|||.| |||.| . |..  . . .|| ..  .  |.....    |||.. |       
ggasafqgfrksmedahialanless....sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantep

FKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAV-QIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKK------YVIGDAEV
 .||||||||||.|  ||| .||||.|.|.|.| || |  | |||..||| .|||.||| |.|.|..||||.| ||||.|| . |.      .|. . ..
stsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdi

SEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGgTKSDAAKSLVQFAYSEGSGDN
|....|  ...|..|.||.||||...|. .   . . |. ....||. ||..|.. || ||
sstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedn
PPM_PTC7_SpoIIE 143-372 1.6e-27 89.8 In-house 3-222 (230) alignment 
Range on Protein: 143-372
Range on HMM: 3-222/230.0
FSAFCMKNKRRKMEDRHSICLDINTLygikGFAHDQTFFGVYDGHVGPEaaDYSSRHVHhNIIRHPSFITDPvlAIKEGIKVTDERF-CSTGFK---SGS
..| .... |..|||.| .. . .      .  .   ..|..||| |..   . ..... ...|  .| . .    .| .. .....   .  .   ||.
ggasaaqgarksmedahispanseks....sggrlalvvgdvdGhGgra..alamgllr.talrelafagle..kpeeilrrlnlalaadledepsssga

TAVVALIRGPM--LYVGWVGDSQAYLVRK-GVavqimephkpdredEQQRIeAAGGLV-INIGVWRVNGNLSVSRAIGDPKDKK---YVIGDAEVSEIEL
|||||||..    ||| ..||| ..|||. |               |  || .||||. . |. .||.|.|.||.|.||   .    .|   .. |..||
TavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepdtsdgel

DGTEDYLVVACDGIWDVVNEEELTSHLEEYFIK---GGTKSDAA
.| ...|..|.||.|||.. .|| ... . . |   .| ..|..
fgkdeflilasdglwdvlspqelvdlvrdelekpaaeglleDDi
subfamily_PPM1D_pd Subfamily PPM1D 144-396 4.4e-29 94.5 In-house 5-308 (309) alignment 
Range on Protein: 144-396
Range on HMM: 5-308/309.0
SAFCMKNKRRKMEDRHSICLDINTLYGikgfAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDP----VLAIKEGIKVTDERFC-------S-
.... .  |. |||. .| |. .          ...|..|.||| | ||| . ..|. ..| ..  |....    . ||.|.   | |            
tseadqGgrkymeDvvaivleeeesae....elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpkt

-TGF--KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGV------AVQIMEPHKPDREDEQQRIEAAGGLVINI-GVWRV---------NGN--------
 .|    .|.|| | .||.  |||. ||||.. |  |        | .... |||.  .|..||| .|| | .  || ||         ||.        
ksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPF

LSVSRAIGD-----PKDKKYVIG-DAEVSEIELDGTED-YLVVACDGIWDVVNEEELTSHLEEYFIKGGT----KSDAAKSLVQFAYSEGSG-----DNL
|.|.|..||      | ...|.  . .|.. .||. |. ....| ||.|.|.. |.  | .|..  |. .    ... || ||. | .. .      ||.
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnv

TAIIVFFD
..|.|...
svivvile
PP2Cc_SM00332 146-393 2.1e-65 213.8 In-house 15-274 (274) alignment 
Range on Protein: 146-393
Range on HMM: 15-274/274.0
FCMKNKRRKMEDRHSICLDINtlygikgFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITD-----PVLAIKEGIKVTDERFCSTGF------
 .|...|..|||.| . .| .         .| .||||.||| |.|.|.. |............. .|     .  |.|.... |||..           
ssmqgwrksmeDahvvvvdlv.......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen

-KSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIgvwRVNGNLSVSRAIGDPKDK-------KYVIGDAEV
 .|||||||||...  ||| .||||.|.|.|.| |||. . |||..||| .||..||| |..    ||||.|.||||.|| . |       .|.. . .|
alsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyitaepdv

SEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGG--TKSDAAKSLVQFAYSE-GSGDNLTAIIV
. ..|.  .. |..|.||.|||....|. .....   ||     ..||. |.. |..  || || |...|
kvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 147-396 1.8e-59 194.4 In-house 18-281 (282) alignment 
Range on Protein: 147-396
Range on HMM: 18-281/282.0
CMKNKRRKMEDRHSICLDINTLygikgfaHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSF----------------ITDPVLAIKEGIKVTDERFC
 |.. |..|||.|..  ....|       .|..|| |.||| | |.|.|...|...||... ..                . .  ||. | |. . ..  
smqgwrvemEDahtvvaslgal.......kdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlk

STgFKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVInigVWRVNGNLSVSRAIGDPKDKK---------YVI
..  |||||||..|..   |..  .||| | |.|.| |.   | |||.|..|..|||.||| |.   | ||||.| ||||.|| . |.          |.
ta.dksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeekkaeeqlvs

GDAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFD
...||  || .  .|.||.||||||||...||...  .. . ..   .  ||.||. |...||.|||....|.|.
aepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
subfamily_ILKAP_pd Subfamily ILKAP 147-362 7.3e-36 116.8 In-house 11-243 (293) alignment 
Range on Protein: 147-362
Range on HMM: 11-243/293.0
CMKNKRRKMEDRHSICLDINTL-YGIKGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFiTDP-------VLAIKEGIKVTDERFCST------
. | .| .|.| | |  |...     | .    ....|.||| |. |........|..|... .  .|          .. .  | ||| | ..      
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsakekeikkclvdsfkktdeefLklaskakP

GFKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGV------AVQIMEPHKPDREDEQQRIEAAGGLVINIgvwRVNGNLSVSRAIGDPKDKKY-VIGDAE
 .| ||||.| |.   .|||. .|||.| ||||        .|..   |.| ...|..||. ||| | .    ||.| | |||.||| . |.  ||   .
vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg...rvlGvlevsrsiGdgrfkrlGvistPd

VSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYF
|. .||.  . ..|.||||.|.|.. .|  ..  . .
vkkceLtendlfvvlaCdGLwkvfsadevvkfilkvl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 148-395 1.7e-48 158.1 In-house 13-253 (255) alignment 
Range on Protein: 148-395
Range on HMM: 13-253/255.0
MKNKRRKMEDRHSIcldintlYGIKGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPS-FITDPVLAIKEGIKVTDERFCSTGFKSGSTAVVALIR
|  .|  |||. .|       ||     .|. .. ..||| | .||...| .... .      . ..|| ..|.  | .. ..   .   |.||...|| 
miGrrptmedelvi.......yGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserpkfiGttaasvlii

GPMLYVGWVGDSQAYLV-RKGVAVQIMEPHKPDREDEQQRIEAAGGLVINI-GVWRVNGNLSVSRAIGDPKDKKYVIGDAEVS-EIELDGTEDYLVVACD
. . |.  ||||.. |  ..|.|...   |||  |.|..||...|| |..     ||||.|.||||.||   . .|. | ..| ..|   .. .|..|||
edkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflilacd

GIWDVVNEEELTSHLeeyfIKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFF
||||.. .||  . .    ..     .||. |  .||| || ||.. |.. .
Giwdlisdeeaveiv....agisdpekaaeklrdlayssGstdnisvivikl
Subfamily Dicty-PPM1L-like 148-205 2.1e-07 23.1 In-house 14-63 (305) alignment 
Range on Protein: 148-205
Range on HMM: 14-63/305.0
MKNKRRKMEDRHSICLDINTlygikgfAHDQTFFGVYDGHVGPEAADYSSRHVhHNII
 .|.|.. |||.  .. ..        .... .|||.||| |  ||.|. ...  .|.
sansrkyqedrnkvkisles.......sqelslfGvfdGhnGdiaaeyvkkkl.veiv
subfamily_PP2D1_pd Subfamily PP2D1 150-206 1.1e-06 20.6 In-house 10-61 (492) alignment 
Range on Protein: 150-206
Range on HMM: 10-61/492.0
NKRRK--MEDRHSICLDintlYGIKgfaHDQTFFGVYDGHVGPEAADYSSRHVHHNIIR
| | |  |||.. .. .    .| .    .. |||.|||. |  ||. .....|. . .
nsrWKskmeDkrtlqdy....fgnd...vnscFfgiyDGynGataAeiaakelhevlle
subfamily_PPM1K_pd Subfamily PPM1K 171-397 1.7e-36 118.7 In-house 24-260 (263) alignment 
Range on Protein: 171-397
Range on HMM: 24-260/263.0
IKGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGIKVTDERFCS---------TGFKSGSTAVVALIR-GPMLYVGWVGDSQA
.| .  .  ...|.||| |. |||.   .... . |      |    .|.  .  |... .         .  .||.|| |.|.| |  | .  .|||.|
lkeldpellyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsra

YLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVI--NIGVWRVNGNLSVSRAIGDPKDKKY-VIGDAEVSEIELDGTED-YLVVACDGIWDVVNEEELTS
 | |.| | .. . |.|..|.|..|| |||| |    .|  .||| |...|..|| . |.| || . |  ....| ..| .||.  ||| .|||..||. 
ilcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcd

HLEEyfikGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFFDS
 ..          .||..|.. |   || || ||..| . .
lvrl....chdpeeaahalteqalqygsednatavvvplga
PP2C_SIG_SM00331 172-394 1.2e-13 44.2 In-house 24-216 (217) alignment 
Range on Protein: 172-394
Range on HMM: 24-216/217.0
KGFAHDQTFFGVYDGHVGPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGIKVTDERfcSTGFKSGSTAVVALI--RGPMLYVGWVGDSQAYLVRKGVAV
     ..... | ||. .  ||   |. ... .  . |  .... |.|. ... .|.  ..   .. |...||.  ..  |..  .|||  ||.|.|  |
vklnegrlllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklv

QIMEPhkpdredeqqrieaagglvinigvwrvngnlSVSRAIGDPKDKKyvigdAEVSEIELDGtEDYLVVACDGIWDVV-----NEEELTSHLEEYFik
.| .                                  ....|  .. .     ....|.||.  .| |. . ||.....     .||.|.  ||...  
eilkd...............................vegaplGlepevs.....vdirelelek.gdllllytDGltearsekgfaeerleeiledlv..

GGTKSDAAK----SLVQFAYSEGSGDNLTAIIVF
. .. . |.    .|...|  ..  |..| ..|.
dseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_KAPP-like_pd Subfamily KAPP-like 179-393 5.5e-23 74.3 In-house 35-264 (266) alignment 
Range on Protein: 179-393
Range on HMM: 35-264/266.0
TFFGVYDGHVGPEAADYSSRHVHHNIIRHPS---------FITDPVLAIKEGIKVTDERFCSTGFKsGSTAVVALIR----GPMLYVGWVGDSQAYLVRK
..|.|.||| |  ||| ... . ... ..            | |    ... .|  |...    .. |.|| .||.       .| |. |||| |.| | 
alfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeye.GatatlalvwsdGqqrylqvanvGdssaflsrG

GVAVQIMEPHKPDREDEQQRIEAAgGLVINIGVWRVNGnLSVSRAIGDPKDKKYVI---GDAEVSE-IELDGTEDYLVVACDGIWDVVNEEELTSHLEEY
  ....   || . ..|.|||    |. .  .  |.|| | ||||.||   |.  |   ..  ||. | |   ...|.|| ||.|||.. ..    ..  
neslelskdhkakdpeekqrikdd.GitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvksl

FIKGGTKSDAAKSLVQFAY-SEGSGDNLTAIIV
. .. |. . |.||.. |  |  . ||.. |.|
ydqqatedkmasslletaiqsikakdnvsvivv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 179-313 2.2e-14 46.7 In-house 21-182 (292) alignment 
Range on Protein: 179-313
Range on HMM: 21-182/292.0
TF-FGVYDGHV--GPEAADYSSRHVHHNIIRHPSFITDPVLAIKEGI----KVTDERFCSTGFKSGSTAVVALIRGP-MLYVGWVGDSQAYLVR-----K
||   |.|||   | . |...  .. ....       .   |.  .|       |. .  .. ......| | .|    |..  ||||.| | |     .
tflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsd

GVAVQIMEPHKPDREDEQQRIEAAGGLVI--------NIGVWRV------NGNLSVSRAIGD
   . .   |||.  ||..|| .||| |           |  ||      .|.|..|||.||
yeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd
subfamily_PHLPP_pd Subfamily PHLPP 219-395 9.1e-16 50.5 In-house 68-245 (246) alignment 
Range on Protein: 219-395
Range on HMM: 68-245/246.0
KEGIKVTDERFCSTGFKSGSTAVVALIRGP--------MLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREdEQQRIEAAGGLVINIGvwRVNGNLSVSRA
|  . |.  .  . | | ||.|.. |||          .| |  ||  ||.|.|.|  ... .... ... | .||  | ... . .  ..|| .. .| 
kntllvaqrklGeaGeklgsaallilirhdkvdPaksfsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitedn..kingviestrl

IGDPKDKKYVIGDAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEeyfiKGGTKSDAAKSLVQFAYSEGSGDNLTAIIVFF
.|      .|. . .|.|. |   ...|.|  . .|.|.. .|... .     |      ||| ||. | | | .|......| .
lGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavr....keedplvaAkklvdlaqsygaadsvsvlvvrl
subfamily_PPM1G_pd Subfamily PPM1G 231-397 7.1e-34 110.6 In-house 291-472 (473) alignment 
Range on Protein: 231-397
Range on HMM: 291-472/473.0
STGFKSGSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGvwRVNGNLSVSRAIGDPKDKKYVIG--------
. | .||.||||||...  |.|  .||| . | |.|.|... . |||. | |..|||.||| |   |  |||| | .|||.||   ||            
epGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqmis

-DAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGG--TKSDAAKSLVQFAY-----SEGSG-DNLTAIIVFFDS
   ..   .|   ...||.||||||.|.. .|   .... . ||   . |.. . |.  .       .|.| || |.||| ...
AlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
subfamily_TAB1_pd Subfamily TAB1 235-318 2.3e-10 32.8 In-house 128-214 (333) alignment 
Range on Protein: 235-318
Range on HMM: 128-214/333.0
KSGSTAVVALIRGPMLYVGWVGDSQAYLVR---KGVAVQIMEPHKPDREDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKK
. |.|||||||    |||  ||||.| ||.   .   .|.   |. | ||| .|..  |  . .|   .. |.    |.||| | ||
sgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkk
subfamily_PDP_pd Subfamily PDP 235-315 2e-06 20.2 In-house 151-239 (398) alignment 
Range on Protein: 235-315
Range on HMM: 151-239/398.0
KSGSTAVVALIRGPMLYVGWVGDSQAYLVRK---G--VAVQIMEPHKPDREDEQQRIEAAGGLVIN---IGVWRVNGNLSVSRAIGDPK
 ||..|..|||.|  |.|  .||..| | ..   |   ||.. . .  | |.| .||...     .   |   |. |.|  .|| || .
lsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvr
PP2C_2 Protein phosphatase 2C 236-378 7.4e-06 18.4 Pfam-A 97-210 (212) alignment 
Range on Protein: 236-378
Range on HMM: 97-210/212.0
SGSTAVVALIRGPMLYVGWVGDSQAYLVR-KGVAVQIMEPHKPDREDEQQRIEAA--GGLVinigvwrvngnlsvsraigdpkdkkyvigdaEVSEIELD
 ..| ..|.|..  ......||. .....  | . .. ||.. . . | ...  .  .. .                               ......|.
yatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...............................rirrlkle

GTeDYLVVACDGIWD-VVNEEELTSHLEEYfIKGGTKSDAAKSLVQF
   | |..  ||..| ...||.....|.|. ..  .. .||..| .|
pg.dalllmTDGvsdslrkeepfrellael.letleeegaaeeLaef
PP2C_2 Protein phosphatase 2C 236-378 7.4e-06 18.4 In-house 97-210 (212) alignment 
Range on Protein: 236-378
Range on HMM: 97-210/212.0
SGSTAVVALIRGPMLYVGWVGDSQAYLVR-KGVAVQIMEPHKPDREDEQQRIEAA--GGLVinigvwrvngnlsvsraigdpkdkkyvigdaEVSEIELD
 ..| ..|.|..  ......||. .....  | . .. ||.. . . | ...  .  .. .                               ......|.
yatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...............................rirrlkle

GTeDYLVVACDGIWD-VVNEEELTSHLEEYfIKGGTKSDAAKSLVQF
   | |..  ||..| ...||.....|.|. ..  .. .||..| .|
pg.dalllmTDGvsdslrkeepfrellael.letleeegaaeeLaef
subfamily_PP2D1_pd Subfamily PP2D1 237-363 4.1e-21 68.2 In-house 177-307 (492) alignment 
Range on Protein: 237-363
Range on HMM: 177-307/492.0
GSTAVVALIRGPMLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAGGLVINIG-VWRVNGNLSVSRA---IGDPKDKKYVIGDAEVSEIELD
 ..  | |.   .||.  .|. || |.|.|.|...   | |  . | .|.| ||. | . . . .||| |.. |    .|||| || || . ..  ..||
sngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkld

GTEDYLVVACDGIWDVVNEEELTSHLEEYFI
 .  .||.|  |.|.|..||| .| ... . 
eaaqflvlAsnGlWevlseeevlsLvkqtla
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 249-393 4e-19 61.5 In-house 127-274 (276) alignment 
Range on Protein: 249-393
Range on HMM: 127-274/276.0
MLYVGWVGDSQAYLVRKGVAVQIMEPHKPDREDEQQRIEAAgGLVINIGVWRVNGnLSVSRAIGDPKDKKYVI---GDAEVSE-IELDGTEDYLVVACDG
 | |. |||| |.| |   ....   || .  .|.|||    |. .  .  |.|| | ||||.||   |.  |   ..  ||. | |   ...|.|| ||
ylqvanvGdssaflsrGneslelskdhkatdpeekqrikdd.GitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdG

IWDVVNEEELTSHLEEYFIKGGTKSDAAKSLVQFAY-SEGSGDNLTAIIV
.|||.. ..    ..  . .. |. . |.||.. |  |  . ||.. |.|
lwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
Subfamily Dicty-PPM1L-like 280-396 5.7e-17 54.5 In-house 180-304 (305) alignment 
Range on Protein: 280-396
Range on HMM: 180-304/305.0
EDEQQRIEAAGGLVINIGVWRVNGNLSVSRAIGDPKDKKYVIGDAEVSEIELDGT-EDYLVVACDGIWDVVNEEELTSHLEEYF-IKGGTK------SDA
.... ||| ... ..| |  .||. |..|| .||   |..|| . .     .  . ...||.| ||.|.|.. ...  ...|   .|   |       . 
deiririeslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfnei

AKSLVQFAYSEGSGDNLTAIIVFFD
 .  |. |.. ||||| | .|... 
srviveeavkrgsgDnitlviiklk
subfamily_PDP_pd Subfamily PDP 319-374 8.6e-07 21.4 In-house 269-324 (398) alignment 
Range on Protein: 319-374
Range on HMM: 269-324/398.0
YVIGDAEVSEIELDGTEDYLVVACDGIWDVVNEEELTSHLEEYFIKGGTKSDAAKS
|.. . || . .|  .. .||.| ||.||....||  |  .|.. |  .|.. . .
YltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkve
PPM_PTC7_motif 339-387 1.2e-09 31.5 In-house 1-50 (51) alignment 
Range on Protein: 339-387
Range on HMM: 1-50/51.0
VVACDGIWDVVNEEELTSHLEEYFIKGGTK-SDAAKSLVQFAYSEGSGDN
. |.||.|||....|. . . .   | |..   ||. ||..| ..|| ||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDn