Gene PPM1G in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP212_AA protein Get Run
AqueP212_AA_22-526 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 4-526 1.6e-203 670.0 In-house 1-472 (473) alignment
Range on Protein: 4-526
Range on HMM: 1-472/473.0
FLTKPITDKTVTNGtigvSDKECQYGTATMQGWRENMEDVITVVTDFDDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSRGFCEAYMNCD
.|.||...|. ...    | .|..||...|||||...||.....||.|...|...|.||||||||..|....||..|||..||..|||.....||....|
ylskpkvekesede....sneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalD

RKLLTEDALKEMKLINESEINEGEEELNGEESGDEVERLTEEAHMPLDKVLQACiedkkllkylinvanrnNGDGSNDDEISSSDGEGMASEEGLGGADN
.|| .|..|||.| |.|.| .|.||| ..||..||.|.|||||..|||..|...                 .||||...|.|....||.|||.. .....
eklkaeeslkelkeiaeaeededeeeeddeededeiellteeaeipldellkrl.................dgdgsekeelsqallegaasedeededed

IKETQRSRVYSQFIKELSVQYKPALNELQTMMGEDSSEGEEEEEEEEEEEGPGEGETEEEGKPviannvrkrkrcDESDEDLKDSKRLKEGRQEMGQALG
 .|...........|| ....|.| .. |....||.|| ||||||.||||....||||||...            ||..|. .|... .|...|..... 
eeeeeeekdteeeskeeekkakaakegkqekkeedesekeeeeeekeeeeedekgeteeeeee............dedeeeeedeeeaeeeeeeedeede

EGGGARGEGEGAKEEGDGDEYHDSEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNgernhhhhhrylllGEAVDLSLDHKPIDPLERERIERAGGHI
|. ...||||.|||| ||.|.....|..||.||.|.|.|.. |.||||||||||||.|              |.|.||||||||.|. |.||||.|||..
eeeeedgegeeakeeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrn..............GkAldlslDHkPeDevEleRiekAGGkv

DEDLRVNGGLNMSRAIGDHMYKTNETLPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSkkdlVLSHICEELCDACL
|||.|||||||.|||.|||.||.||.||||.|||||.||.....|...|.|||||.|||||...||.||||..||| ....|    |||.|.|||.||||
dedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees....vlseiveeLlDacl

AEDIDNDGTGCDNMSIIITLLKP
|.|...||||||||..||.|||.
apdtsgDGtGCDnmtviivllkk

subfamily_PPM1G2_pd Subfamily PPM1G2 5-114 6.9e-22 70.7 In-house 2-112 (287) alignment
Range on Protein: 5-114
Range on HMM: 2-112/287.0
LTKPITDKTVTNGtigvSDKECQYGTATMQGWRENMEDVITV----VT-DFDDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSRGFCEAY
|..|...|  . .    ... .. |...|||.| ||||  ..    .. . |.......|||||||..|. |....|  ....   ...| ... . .|.
lsepvvakesasc....analtkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaf

MNCDRKLLTEDALKE
...|..|| ...||.
letDeellkdeklkd

PP2Cc_SM00332 23-522 6.9e-78 254.8 In-house 7-274 (274) alignment
Range on Protein: 23-522
Range on HMM: 7-274/274.0
DKECQYGTATMQGWRENMEDVITVVTDFD--DKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVsrgfceaymncdrKLLTEDALKEMKLINE
.....||...|||||..|||.. ||.|..  .. .| ||||||||.||. ..|..|| .|| .  .....              .  .|.|||.  | ..
nlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.............eddveealkkaflstd

SEINEGEEELNGEEsgdeverlteeahmpldkvlqaciedkkllkylinvanrnngdgsnddeisssdgegmaseeglggadniketqrsrvysqfikel
.||.| |. .. |.                                                                                      
eeileeeqskelen......................................................................................

svqykpalnelqtmmgedssegeeeeeeeeeeegpgegeteeegkpviannvrkrkrcdesdedlkdskrlkegrqemgqalgegggargegegakeegd
                                                                                                    
....................................................................................................

gdeyhdsegHESGSTATVCLIKTNILYVANAGDSRCVLSSNGErnhhhhhrylllgeAVDLSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNMSRAIG
           |||||.|.|.| . |||||.||||.||..||.              ||.|| |||| |. ||.||..|||..  . ||||||..|||.|
.........alsGstavvallkkedlyvanvGDSravlcrngk..............avqlsvdhkpedederkRikkaggvvekg.rvngglavsrafG

DHMYKTNEtlPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVrnskkdlV--LSHICEELCDACLAEDidndGTGCDNMS
|| .|.|.  .||...|.| |||..  | ..|.||.|||||.|..|..|.|||.....| .        .    . ..||.|......    |...||..
dhflkknk..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg.......ktndpqeaaelldeeairr....ggseDniT

IIIT
....
vvvv

subfamily_PPM1A_pd Subfamily PPM1A 23-130 2.9e-16 52.7 In-house 9-109 (282) alignment
Range on Protein: 23-130
Range on HMM: 9-109/282.0
DKECQYGTATMQGWRENMEDVITVVTDFDDK--CSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDgdvsrgfceAYMNCDRKLLTEDALKEMKLINE
... .|| ..||||| .|||  |||...      ||  |||||.|.||. |...||.. .  .  ...         | .. . |  ...||..  |  .
gnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelke.........aaleasekdevkealrqgfLald

SEINEGEEEL
..|.| ...|
eairelstdl

0034914 PP2C-like 26-526 2.2e-69 226.4 In-house 21-292 (295) alignment
Range on Protein: 26-526
Range on HMM: 21-292/295.0
CQYGTATMQGWRENMEDVITVVTDF---DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKA-------SVGYQDGDVSRGFCEAYMNCDRKLLTEDALKem
 ..|.|..||.|...|| ..||...   .......|||||||| ... ..|..|. .|.        .  . . |. . . .|....|..||..  |.  
lrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr..

klineseinegeeelngeesgdeverlteeahmpldkvlqaciedkkllkylinvanrnngdgsnddeisssdgegmaseeglggadniketqrsrvysq
                                                                                                    
....................................................................................................

fikelsvqykpalnelqtmmgedssegeeeeeeeeeeegpgegeteeegkpviannvrkrkrcdesdedlkdskrlkegrqemgqalgegggargegega
                                                                                                    
....................................................................................................

keegdgdeyhdSEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNM
           .|   ||.||.|.||. | |||||.||||.||..||              |.| |. |||| ..||||||..||| .  . ||||.|..
...........pelagsGtTavvalirgnklyvanvGDSravllrng..............elvqltvdhkpvnelererilsaggavshg.rvngvlav

SRAIGDHMYKTNETLPLKDQMISAYPDVHTRLLQ-TQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNskkdlvLSHICEELCDACLAedidndGTGC
.||.||. .|.. .|.|.....||.|||... |.  .|.||.|||||.|..|.....||...  | .  .      |....|||.|..||      . ..
tRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld......leeaaeeLvdlAla......rgsr

DNMSIIITLLKP
||.....  |..
DNiTvvvvrlng

0049733 PP2C-like 27-108 4.7e-12 39.0 In-house 4-81 (235) alignment
Range on Protein: 27-108
Range on HMM: 4-81/235.0
QYGTATMQGW-RENMEDVITVvtdfddKCSFLGVFDGHGGKEVSVYCSRHLPGFLKAS-VGYQDGDVSRGFCEAYMNCDRKLLT
..|.|...|. |...|| . |      ......|.||||| ... ..|..|. .|..   ..   |. . . .|.. ... || 
svgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaanealle

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 27-104 3.7e-08 26.0 In-house 7-86 (255) alignment
Range on Protein: 27-104
Range on HMM: 7-86/255.0
QYGTATMQGWRENMEDVITVVTDFDDKC--SFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSRGFCEAYMNCDR
. | . | | |  ||| ...   | ||    .. .||||||.. . ..| .|.  |.  .  .. .  . . .|| . . 
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeist

PPM_PTC7 28-105 3.2e-12 39.4 In-house 3-88 (259) alignment
Range on Protein: 28-105
Range on HMM: 3-88/259.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDG-DVSRGFCEAYMNCD--RK
.|   .||.|..|||. ..  ..     .|. .|..||||||| |.. |.. ||...|| .   ... ...... ......|   .
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdee

PP2C Protein phosphatase 2C 28-110 7.8e-12 38.3 Pfam-A 3-92 (255) alignment
Range on Protein: 28-110
Range on HMM: 3-92/255.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDG-DVSRGFCEAYMN-CDRKLLTED
.|  ..||.|..||| ..   ..     ... .|..||||||| |.. |.. ||...|| .   ... .|.... .....  | .| ...
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelkssk

PP2C Protein phosphatase 2C 28-110 7.8e-12 38.3 In-house 3-92 (255) alignment
Range on Protein: 28-110
Range on HMM: 3-92/255.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDG-DVSRGFCEAYMN-CDRKLLTED
.|  ..||.|..||| ..   ..     ... .|..||||||| |.. |.. ||...|| .   ... .|.... .....  | .| ...
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelkssk

PPM_PTC7_SpoIIE 28-105 2.2e-08 27.2 In-house 3-83 (230) alignment
Range on Protein: 28-105
Range on HMM: 3-83/230.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEvsVYCSRHLPGFLKASVgYQDGD-VSRGFCEAYMNCDRK
.|   .||.|..|||. ..  ..     ..   ..|..||||| .   .....| ..|..   ..... ..  . ... .....
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaad

subfamily_PPM1K_pd Subfamily PPM1K 29-108 4.4e-08 25.6 In-house 7-84 (263) alignment
Range on Protein: 29-108
Range on HMM: 7-84/263.0
GTATMQGWRENMEDVITVvTDFDDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVgYQDGDVSRGFCEAYMNCDRKLLT
|.....| |.. || |.. ...|..  ...|||||.|     ..  .|   ||     .. |.   . .|. ..|.||  
GkdsliGkraenedrikl.keldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkr

subfamily_PPM1E_pd Subfamily PPM1E 30-109 1.1e-09 30.8 In-house 8-94 (265) alignment
Range on Protein: 30-109
Range on HMM: 8-94/265.0
TATMQGWRENMEDVITVVTDF--------DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLkASVGYQDGDVSRGFCEAYMNCDRKLLTE
.|.... |  |||   .. |.        ... .|..||||||| | . | ..||. .| ..   .  |  . ..||. ..|...|. 
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhell.vrqeklkedpaealkeafkltDerflqk

subfamily_ILKAP_pd Subfamily ILKAP 30-109 3e-08 26.2 In-house 9-103 (293) alignment
Range on Protein: 30-109
Range on HMM: 9-103/293.0
TATMQGWRENMEDVITVVTDFDD----------KCSFLGVFDGHGGKEVSVYCSRHLPG-----FLKASVGYQDGDVSRGFCEAYMNCDRKLLTE
 |  .| ||.|.|. ... |.|.          . |. .|||||.|.  | .....|       . | .|  .. .. . . ... . |...|..
yaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLkl

subfamily_PPM1L_pd Subfamily PPM1L 30-88 6.5e-08 25.1 In-house 9-69 (269) alignment
Range on Protein: 30-88
Range on HMM: 9-69/269.0
TATMQGWRENMEDVITVVTDFDDKC--SFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQD
. ...| |..||| ... .| ..|   ||..|||||||.  . ..   |.  .|. .   |
vysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklield

subfamily_PPM1D_pd Subfamily PPM1D 31-106 1.1e-12 40.7 In-house 7-90 (309) alignment
Range on Protein: 31-106
Range on HMM: 7-90/309.0
ATMQGWRENMEDVITVVTDFDDK-----CSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGY---QDGDVSRGFCEAYMNCDRKL
.. || |. ||||...|.. ...      .|..||||||||| . . ..|| ...|   ..   .. || .   ||.... ...
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheam

subfamily_PP2D1_pd Subfamily PP2D1 36-163 1.8e-08 26.5 In-house 13-138 (492) alignment
Range on Protein: 36-163
Range on HMM: 13-138/492.0
WRENMEDVITVVTDFDDK--CSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSrgfceayMNCDRKLLTEDALKEMKLINESeINEGEEELNGE
|. .|||  |.. .| ..   .|.|..||. |.     ....|.  |   .   |  ||       . .. .|. .. | . .|   | ...   . . |
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervs.......lttavnlidnndltdyeleras.rsdsirailke

ESGD----EVERLTEEAHMPLDKVLQACIEDKKL
|| .    .|..  ..... ||..|.  ||.. .
esvkpefekvkkAfrksylrldrlLsygieeesr

subfamily_PP2D1_pd Subfamily PP2D1 317-491 1.7e-19 62.9 In-house 162-319 (492) alignment
Range on Protein: 317-491
Range on HMM: 162-319/492.0
EEGDGDEYHDSEGHESGStATVCLIKTNILYVANAGDSRCVLSSNGERNHhhhhrylllgeavdLSLDHKPIDPLERERIERAGGHI---DEDLRVNGGL
|. . .. ..   .|| .   | |... .||.||||. . ||  .|.  .              |  .| | .. ||.|.|.||. .   ..  .||| |
ekeekkdseeGlekesng.sevhleelgvlyianaGnvqAvLcreGkaii..............LtreHtprnkkERtRvekagsvvvkseknglvnGil

NMSRAIGDHmyktnETLPLKDQMISAyPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVR-NSKKDLVL
.  | .| .       . ||  .| . | ...  |. ..||||||| |.|. |. ..|.  ..  |   . . ... | 
dttRGLGny.....GdpkLkksvipe.PkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvp

PP2C Protein phosphatase 2C 322-505 2.1e-50 164.7 Pfam-A 91-249 (255) alignment
Range on Protein: 322-505
Range on HMM: 91-249/255.0
DEYHDsEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylllgeaVDLSLDHKPIDPLERERIERAGGHIDEDLRVNGGLNMSRAIGD
.. .. |   |||||.|.||. . |||||.||||.||.....               . |. |||| |. ||||||.||| ...  |||| |..|||.||
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.............keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGd

HMYKTNEtlplkDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRnskkdlVLSHICEELCDACLAE
. .| .|      |..|| |||... |. .|.||.|||||.|..|..|..||... .| . .       .. ..|||.| ..| 
felkpke.....eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiar

PP2C Protein phosphatase 2C 322-505 2.1e-50 164.7 In-house 91-249 (255) alignment
Range on Protein: 322-505
Range on HMM: 91-249/255.0
DEYHDsEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylllgeaVDLSLDHKPIDPLERERIERAGGHIDEDLRVNGGLNMSRAIGD
.. .. |   |||||.|.||. . |||||.||||.||.....               . |. |||| |. ||||||.||| ...  |||| |..|||.||
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.............keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGd

HMYKTNEtlplkDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRnskkdlVLSHICEELCDACLAE
. .| .|      |..|| |||... |. .|.||.|||||.|..|..|..||... .| . .       .. ..|||.| ..| 
felkpke.....eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiar

subfamily_PPM1K_pd Subfamily PPM1K 324-476 3.4e-20 65.3 In-house 90-226 (263) alignment
Range on Protein: 324-476
Range on HMM: 90-226/263.0
YHDSEGHESGSTATVCLIKT-NILYVANAGDSRCVLSSNGErnhhhhhrylllgeAVDLSLDHKPIDPLERERIERAGGHID----EDLRVNGGLNMSRA
. ..|  .||.||||.|..  . | .|. |||| .|  ||.              |  |. ||.|    |.||| .|||...    . ..||| | |.|.
vaeaellssGttatvsllrdGtelvlaslGdsrailcrnGk..............akkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrs

IGDhmyktnetLPLKDQMISAYPDVHTR-LLQTQDQFLVLASDGIWNCLDSQQVVDFIN
.||        | ||   . | |. ..  .  ..| |||| .||| . ..||.. |...
lGd........ldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr

PP2C_SIG_SM00331 324-505 5.5e-13 42.0 In-house 78-204 (217) alignment
Range on Protein: 324-505
Range on HMM: 78-204/217.0
YHDSEGHESGSTATVCLI--KTNILYVANAGDSRCVLSSNGERNHHHHH-RYLLLGEAVDLSldhkpidplererieragghidedlrvngglnmsraig
|. .| .... |....|.  ... |..|||||||..|  .|.. ..... .  .||  ...|                                      
yeekeekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkdvegaplGlepevs......................................

dhmyktnetlplkdqmisayPDVHTRLLQTqDQFLVLASDGIWNCLDSQQ-----VVDFINAKLlevrNSKKDLVLSHICEELCDACLAE
                    .|.... |.  . .|.|..||...   ...     . ... ...    .| .. . ..| |||. .  ..
....................vdirelelek.gdllllytDGltearsekgfaeerleeiledlv....dseaqelaqkiveellelakgs

PPM_PTC7 325-507 5e-49 160.1 In-house 95-255 (259) alignment
Range on Protein: 325-507
Range on HMM: 95-255/259.0
HDsEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylllgeaVDLSLDHKPIDPLERERIERAGGHID--EDLRVNGGLNMSRAIGDH
.. |   |||||.|.||  . |||||.||||.||...|.               . |. |||| .. ||||||.||| ..  .. |||| |..|||.||.
nt.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav.............kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdf

MYKTNETlplKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVrnskkdlVLSHICEELCDACLAEDI
 .| .||   . |..|| ||.... .. .|.||.|||||.|.....|..||...  | .         .. ..|.|.| ..| ..
elkpket...eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.......dpmeaaeklvdeaiargs

PPM_PTC7_SpoIIE 325-482 1.9e-25 83.0 In-house 81-212 (230) alignment
Range on Protein: 325-482
Range on HMM: 81-212/230.0
HDSEGHE---SGSTATVCLIKTNI--LYVANAGDSRCVLSSNGERnhhhhhrylllgeavdlsldhkpidplERERIeRAGGHID---EDLRVNGGLNMS
.. . .|   ||.||.|.||  .   |||||||||...|......                           |||||  ||| ..   .. ||.| |..|
aadledepsssgaTavvalidpstgklyvanaGdsppllvrddgg...........................ereri.vagglpslGilpgrvfgvlavs

RAIGDHMYKTnetlplKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEV
.|.||  ..       .|....| ||  . .|   |.||.|||||.|..|..|..||..   |.. 
lapGdlllly......tDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp

subfamily_PPM1A_pd Subfamily PPM1A 326-524 3.3e-45 147.6 In-house 109-280 (282) alignment
Range on Protein: 326-524
Range on HMM: 109-280/282.0
DSEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDeDLRVNGGLNMSRAIGDHMYK
 .. ..|||||...|.. . |..||.|||| ||..||              .|. |. ||||..| |..||| |||..    |||| | .|||.||. ||
lktadksGsTavtvlvsekhliianlGDsRavlcrng..............kaaflteDHkpsrpkEkkRieqAGGsvv.vsRvnGaLAvsRalGDyeyk

TNETLPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSKKdLvlshiCEELCDACLAEDidndgtGCDNMSIIITLL
..|... ..|..|| |.|..   ...|.|||||.||||  |....||.... .|    . .. .     ...| | .| ..        ||.|... |.
eeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadelee.v.....akalvdkalekg......srDNlsvlvvlf

subfamily_PPM1E_pd Subfamily PPM1E 327-526 1.7e-29 95.8 In-house 97-264 (265) alignment
Range on Protein: 327-526
Range on HMM: 97-264/265.0
SEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGErnhhhhhrylllgeAVDLSLDHKPIDPLERERIERAGGHID--EDLRVNGGLNMSRAIGDHMY
.|. .||||| |.||... ||||  |||. .| ..||              || |   ||| .. |..||| ||| .   . .|||| |..||||||  .
reklksGstavvvliekdqlyvaWlGDsqallvrkge..............avqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvkl

KtnetlplkdQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEvRNSKKdlvlSHICEELCDACLAEDidndgtGCDNMSIIITLL
|         ...|. .|| .  |. ....|.||.||.|. .. ..||. ... | .  ....    |.. ..|..|   ..        ||..... .|
k.........pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveeflad.gaedl....sevakllveaakeag......ssDnitvvvvfl

KP
.|
dp

subfamily_PPM1G2_pd Subfamily PPM1G2 328-524 3.7e-54 176.6 In-house 111-286 (287) alignment
Range on Protein: 328-524
Range on HMM: 111-286/287.0
EGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGErNHHhhhryLllgeavdlSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNMSRAIGDHMYKTN
. ...||||.| ||| . ||||||||||.||||.|.  .      |        |.|||| .  |..||. ||| .. . |||| | .|||.||...|.|
kdesaGstavvvlikeeklyvanaGDsravlsskgn.vka.....l........sfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkkn

ETLPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNskkdlvLSHICEELCDACLAEDIDNDGTGCDNMSIIITLL
.... ..|.. |.||| .. |. .| ||||| ||||..| ...|||... .| . ..      |..|.||| | |||.| .| | |||||...|  |
vkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgak......ldeiieelldkclapdssntgvGcDnmtvvivvl

0049733 PP2C-like 328-524 1.1e-35 116.2 In-house 88-233 (235) alignment
Range on Protein: 328-524
Range on HMM: 88-233/235.0
EGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIdedlRVNGGLNMSRAIGDHMYKtn
| . .|.||.|.|. .. |||||.||||..| ..|              ..| |. ||.| ..|||.||..|||..    ||.|.| ..||.||...|  
elagmgtTavvalldggklyvanvGDsrayllrdg..............klvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllk..

etlplkdqmisayPDVHTRLLQTQDqFLVLASDGIWNCLDSQQVVDFINAkllevrnskkdLVLSHICEELCDACLAedidndGTGCDNMSIIITLL
             |||..  |. .| ||.|||||.|..|.....||...            | |....|.|....||      . |.||.....  |
.............pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs...........ldleeaaerlvelala......rggrDNiTvvvvrl

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 329-422 2.1e-14 46.8 In-house 81-183 (292) alignment
Range on Protein: 329-422
Range on HMM: 81-183/292.0
GHESGSTATVCLIKTNI--LYVANAGDSRCVLSS--NGERNhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHID----------EDLRV-----
  ||..||.|| .  .   |..|| ||||..|     | ..           | . || |||| || ||.|| ||||...             ||     
aresattavvcarvrddralilanvGdsrallgrclggsdy...........eliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrq

-NGGLNMSRAIGDH
 .|.| .|||.|| 
qeGdlalsralGdf

subfamily_PPM1L_pd Subfamily PPM1L 330-492 8.3e-27 87.1 In-house 104-249 (269) alignment
Range on Protein: 330-492
Range on HMM: 104-249/269.0
HESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllGEAVDLSLDHKPIDPLERERIERAGGHID--EDLRVNGGLNMSRAIGDHmyktn
...|.|| . |.. . | ||| |||| ||  .              |.|. || |||| .. || ||..||| |      ||.| | .|||.||.     
diaGttalialvqesdlivanvGdsrGvlydkr.............GkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdy.....

etlPLKDQ-MISAYPDVHTR-LLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSKKDLVLS
   ||||. .. | ||. |  | . . .||.|||||.|...  .. | ||  .| |     | ||| 
...plkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvle

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 330-476 1.5e-26 86.2 In-house 93-221 (255) alignment
Range on Protein: 330-476
Range on HMM: 93-221/255.0
HESGSTATVCLIKTNILYVANAGDSRCVLSsngernhhhhhryLLLGEAVDLSLDHKPIDPLERERIERAGGHIDED---LRVNGGLNMSRAIGDHMYKt
   |.||.. ||  .  |.|| |||| ||.                | |. ||||||| .. |..||...|| . ..    |||| | .|||.||   . 
kfiGttaasvliiedkvyianvGdsrvvlc.............qkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle.

netlPlkdqMISAYPDVH-TRLLQTQDQFLVLASDGIWNCLDSQQVVDFIN
    |     . . ||.. .   ...|.||.|| ||||. .  .. |. . 
....P....fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiva

subfamily_PPM1H_pd Subfamily PPM1H 330-397 2.9e-08 25.9 In-house 160-211 (404) alignment
Range on Protein: 330-397
Range on HMM: 160-211/404.0
HESGSTATVCLIKTNILYVANAGDSRCVLSSNGERnhhhhhrylllgeaVDLSLDHKPIDplERERIE
 . | || | |. .. |||||||||| .|. ..|               ..|| |. |    ||.|. 
ikGGCtalvalvllgklYvanaGDsRailvrkdei..............iplsadftPet..eRqRlq

subfamily_PPM1D_pd Subfamily PPM1D 331-525 2.2e-24 79.1 In-house 107-308 (309) alignment
Range on Protein: 331-525
Range on HMM: 107-308/309.0
ESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylLLGEAVDLSLDHKPIDPLERERIERAGGHIDED------------LRVNGG------
 .|.||.| .|. . ||||. |||. ||... ...           .|  |  |||| .| |.||||..||.. .             |. ||       
taGttasvviirreklyvahvGDsaivlgvkepke........kklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvidei

--LNMSRAIGDhMYKTNETlpLKDQMISAYPDVHTRLLQTQDQ-FLVLASDGIWNCLDSQQVVDFINAKLLEVRNS-KKDlvlSHICEELCDACLAEdID
  |...|..|| ..  |..   .  ..|  |||  | |..... |..|||||.||.| ....|.... .        ...   ... . | .  | .   
PFLavaRslGD.lWsynak..sgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs...rsvakalvkealqr.wr

NDGTGCDNMSIIITLLK
.    .||.|.|. .|.
skklraDnvsvivvile

subfamily_PDP_pd Subfamily PDP 331-485 2.8e-21 69.1 In-house 151-318 (398) alignment
Range on Protein: 331-485
Range on HMM: 151-318/398.0
ESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNHHhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDE-----DLRVNGGLNMSRAIGDHMYK
 ||..|.. ||. . |.|||.||.|.|| .. |. .          ||| || |.    . | |||...  . ..     . |. | |  .|| ||  ||
lsGacallaliegtelhvAntGDcravlgvqeeegsw.........eavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryK

TNET---LPLKD---Q-----------MISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNS
 .|     .|..   .            ..| |.| .. |...|.|||||.||.|..|....||. ..  | .  ..
wseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkek

subfamily_ILKAP_pd Subfamily ILKAP 332-487 2e-32 105.5 In-house 113-250 (293) alignment
Range on Protein: 332-487
Range on HMM: 113-250/293.0
SGSTATVCLIKTNILYVANAGDSRCVLSSNGERNHHhhhrylllGEAVDLSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNMSRAIGDHMYKTNEtlp
 ||||||.|.  |.||||| |||..||  . |  ..          .| |. ||.|..  ||.||..|||.. .. ||.| |..||.|||  .|.     
dGstatvvlvldnvlyvanlGdskavlvrkkeegdk........iasvvLtkdhtpvkyeerkriqkaGgvvrdg.rvlGvlevsrsiGdgrfkrlG...

lkdqmISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVrNSKK
     ... |||.   |.  |.|.||| ||.|. .. ..||.||.. | .  ....
.....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvlede.eddr

subfamily_KAPP-like_pd Subfamily KAPP-like 332-477 2.8e-17 55.6 In-house 100-230 (266) alignment
Range on Protein: 332-477
Range on HMM: 100-230/266.0
SGSTATVCLIK----TNILYVANAGDSRCVLSSNgErnhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDE-DLRVNgGLNMSRAIGDHMYKT
 |.|||..|.        | ||| |||   ||   .             |.. || |||  || |. ||   |  . . . |.| || .|||.|||. | 
eGatatlalvwsdGqqrylqvanvGdssaflsrG.n.............eslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfike

NETlplkdqMISAYPDVHTRL-LQTQDQFLVLASDGIWNCLDSQQVVDFINA
 .        ... | |  |. |  .|.||..||||.|. .. .. .. ...
lni......GlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvks

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 332-477 3.4e-17 55.2 In-house 104-240 (276) alignment
Range on Protein: 332-477
Range on HMM: 104-240/276.0
SGSTATVCLIKTNILYvANAGDSRCVLSSNGERNhhhhHRYLLLG-EAVDLSLDHKPIDPLERERIERAGGHIDE-DLRVNgGLNMSRAIGDHMYKTNET
 |.|||..|. ..     .  . | . ..|          .|  | |.. || |||  || |..||   |  . . . |.| || .|||.|||. |  . 
eGatatlalvwsdGee.qqqqqqrylqvanvGds....saflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikelni

lplkdqMISAYPDVHTRL-LQTQDQFLVLASDGIWNCLDSQQVVDFINA
       ... | |  |. |  .|.||..||||.|. .. .. .. ...
......GlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvks

subfamily_TAB1_pd Subfamily TAB1 332-498 1.7e-14 46.3 In-house 129-295 (333) alignment
Range on Protein: 332-498
Range on HMM: 129-295/333.0
SGSTATVCLIKTNILYVANAGDSRCVLSSNGErnhhhhhryllLGEAVDLSLDHKPIDPLERERIERAGGHIDED--LRVNGGLNMSRAIGDHM----YK
 |.|| | ||  | |||||.|||| .|  . |             . . || ||.   . | .|... |  |..    .. |. .  |.|||.     ||
gGttAvvalifnnkLyVaNvGdsrAllvkrke...........sekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgyk

TNETLP-LKDQMISAYPDVHTR-LLQTQDQFLVLASDGIWNCLDSQQVVDFINAK--LLEV-RNSKKDLVLSHICEEL
 .. |   |.. . | ||..    ..   .|||| |||. ..|.  .  .  | .  ||||  . .|.  |. . ...
dvdilssakgePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqav

subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 332-512 1.1e-06 20.1 In-house 134-309 (317) alignment
Range on Protein: 332-512
Range on HMM: 134-309/317.0
SGSTATVCLIKTN-ILYVANAGDSRCVLSSNGERNHHHHHRYLLlgEAvdLSLDHKPIDPLERERIERA---GGHIDEDLRVNGGLNMSRAIGDHMYKTN
 |.||.| ..  .  . ||||||. ...  .   .| .   . .  ||  ||  |.     ||.|.. .    .|. ||  .    .  .|    . |. 
fGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsv..ea..lsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltksl

ETLPLKDQMISAYPDVHTRLLQTQDQFLVLA-SDGIWNCLDSQQVVDFINAKLLEVRNSkkdlvlSHICEELCDACLAEDIDNDGT
    ||   ..| |.|..| |.... | |.. |||| . |  ..|.| .         |        .|..  | .|.|.  .| |
GhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleas......evlcddaqdylldetsiddat

subfamily_PHLPP_pd Subfamily PHLPP 388-478 2.6e-09 29.3 In-house 134-215 (246) alignment
Range on Protein: 388-478
Range on HMM: 134-215/246.0
IDPLERERIERAGGHIDEDLRVNGGLNMSRAIGdHMYKTNETLPlkdqmisaYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAK
|.  | .||  | . |.|| ..|| .. .| .| ...     ||         | |.  ||..|| .|.. .. .|. |. ...|. .  .
iekdelkrikeakaiitednkingviestrllG.ytflfPvvlP........kphvrevlLteqdellivGnkalWevlsideaveavrke

Subfamily Dicty-PPM1L-like 392-487 1.3e-11 36.9 In-house 182-271 (305) alignment
Range on Protein: 392-487
Range on HMM: 182-271/305.0
ERERIERAGGHIDE--DLRVNGGLNMSRAIGDHMYKTNETlPLKDQMISAypdvhtrLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSKK
.| ||| ... . .  .|.||. |. || .||   |     | .|. .         . ...||||||| ||.|. |. |.||......| .   .||
iririeslqaalynygellvnrllkksrskGdknlkelvi.Pnndspllv.......vakanDqflvlatdGlwevlsyqdvveevkellrdkssqkk

subfamily_PPM1H_pd Subfamily PPM1H 408-485 1.3e-09 30.3 In-house 276-357 (404) alignment
Range on Protein: 408-485
Range on HMM: 276-357/404.0
RVNGGLNMSRAIGDHMYKTNE-TLPLKdQMISAYPDVHTRLLQ----TQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNS
|. . . ..| .|||  |. . .| .|  ..|. |.|... |.    ..|. |.||.||.|. |. ..|   ..  | .| ..
RllatigvtRGlGDheLkvvdtnlsik.PfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepe

PPM_PTC7_SpoIIE_motif 453-521 8.7e-06 19.3 In-house 13-77 (81) alignment
Range on Protein: 453-521
Range on HMM: 13-77/81.0
QFLVLASDGIW-------NCLDSQQVVDFINAKllevrnSKKDlvLSHICEELCDACLAediDNDGTGCDNMSIII
  |.|..||..       .... .........       ..|.  | .....|.|..|.    ..|   |......
dvllLyTDGltEardsdgelfgkeellrladra......egks..lqeladklvdevle...ngsgereDDitllv

PPM_PTC7_motif 456-506 3.6e-11 36.4 In-house 1-46 (51) alignment
Range on Protein: 456-506
Range on HMM: 1-46/51.0
VLASDGIWNCLDSQQVVDFINAKLLEVRNskkdlVLSHICEELCDACLAED
.|||||.|..|..|..||...  | . ..      .  ..|.|.| .||. 
iLAsDGLWDvlsdqeavdlvrdqlskkgl.....spqeaAeklvdealarg