Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PPM1G_pd | Subfamily PPM1G | 4-526 | 1.6e-203 | 670.0 | In-house | 1-472 (473) | alignment | ||
Range on Protein: 4-526
Range on HMM: 1-472/473.0
FLTKPITDKTVTNGtigvSDKECQYGTATMQGWRENMEDVITVVTDFDDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSRGFCEAYMNCD
.|.||...|. ... | .|..||...|||||...||.....||.|...|...|.||||||||..|....||..|||..||..|||.....||....|
ylskpkvekesede....sneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalD
RKLLTEDALKEMKLINESEINEGEEELNGEESGDEVERLTEEAHMPLDKVLQACiedkkllkylinvanrnNGDGSNDDEISSSDGEGMASEEGLGGADN
.|| .|..|||.| |.|.| .|.||| ..||..||.|.|||||..|||..|... .||||...|.|....||.|||.. .....
eklkaeeslkelkeiaeaeededeeeeddeededeiellteeaeipldellkrl.................dgdgsekeelsqallegaasedeededed
IKETQRSRVYSQFIKELSVQYKPALNELQTMMGEDSSEGEEEEEEEEEEEGPGEGETEEEGKPviannvrkrkrcDESDEDLKDSKRLKEGRQEMGQALG
.|...........|| ....|.| .. |....||.|| ||||||.||||....||||||... ||..|. .|... .|...|.....
eeeeeeekdteeeskeeekkakaakegkqekkeedesekeeeeeekeeeeedekgeteeeeee............dedeeeeedeeeaeeeeeeedeede
EGGGARGEGEGAKEEGDGDEYHDSEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNgernhhhhhrylllGEAVDLSLDHKPIDPLERERIERAGGHI
|. ...||||.|||| ||.|.....|..||.||.|.|.|.. |.||||||||||||.| |.|.||||||||.|. |.||||.|||..
eeeeedgegeeakeeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrn..............GkAldlslDHkPeDevEleRiekAGGkv
DEDLRVNGGLNMSRAIGDHMYKTNETLPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSkkdlVLSHICEELCDACL
|||.|||||||.|||.|||.||.||.||||.|||||.||.....|...|.|||||.|||||...||.||||..||| ....| |||.|.|||.||||
dedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees....vlseiveeLlDacl
AEDIDNDGTGCDNMSIIITLLKP
|.|...||||||||..||.|||.
apdtsgDGtGCDnmtviivllkk
|
|||||||||
subfamily_PPM1G2_pd | Subfamily PPM1G2 | 5-114 | 6.9e-22 | 70.7 | In-house | 2-112 (287) | alignment | ||
Range on Protein: 5-114
Range on HMM: 2-112/287.0
LTKPITDKTVTNGtigvSDKECQYGTATMQGWRENMEDVITV----VT-DFDDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSRGFCEAY
|..|...| . . ... .. |...|||.| |||| .. .. . |.......|||||||..|. |....| .... ...| ... . .|.
lsepvvakesasc....analtkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaf
MNCDRKLLTEDALKE
...|..|| ...||.
letDeellkdeklkd
|
|||||||||
PP2Cc_SM00332 | 23-522 | 6.9e-78 | 254.8 | In-house | 7-274 (274) | alignment | |||
Range on Protein: 23-522
Range on HMM: 7-274/274.0
DKECQYGTATMQGWRENMEDVITVVTDFD--DKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVsrgfceaymncdrKLLTEDALKEMKLINE
.....||...|||||..|||.. ||.|.. .. .| ||||||||.||. ..|..|| .|| . ..... . .|.|||. | ..
nlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.............eddveealkkaflstd
SEINEGEEELNGEEsgdeverlteeahmpldkvlqaciedkkllkylinvanrnngdgsnddeisssdgegmaseeglggadniketqrsrvysqfikel
.||.| |. .. |.
eeileeeqskelen......................................................................................
svqykpalnelqtmmgedssegeeeeeeeeeeegpgegeteeegkpviannvrkrkrcdesdedlkdskrlkegrqemgqalgegggargegegakeegd
....................................................................................................
gdeyhdsegHESGSTATVCLIKTNILYVANAGDSRCVLSSNGErnhhhhhrylllgeAVDLSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNMSRAIG
|||||.|.|.| . |||||.||||.||..||. ||.|| |||| |. ||.||..|||.. . ||||||..|||.|
.........alsGstavvallkkedlyvanvGDSravlcrngk..............avqlsvdhkpedederkRikkaggvvekg.rvngglavsrafG
DHMYKTNEtlPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVrnskkdlV--LSHICEELCDACLAEDidndGTGCDNMS
|| .|.|. .||...|.| |||.. | ..|.||.|||||.|..|..|.|||.....| . . . ..||.|...... |...||..
dhflkknk..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg.......ktndpqeaaelldeeairr....ggseDniT
IIIT
....
vvvv
|
|||||||||
subfamily_PPM1A_pd | Subfamily PPM1A | 23-130 | 2.9e-16 | 52.7 | In-house | 9-109 (282) | alignment | ||
Range on Protein: 23-130
Range on HMM: 9-109/282.0
DKECQYGTATMQGWRENMEDVITVVTDFDDK--CSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDgdvsrgfceAYMNCDRKLLTEDALKEMKLINE
... .|| ..||||| .||| |||... || |||||.|.||. |...||.. . . ... | .. . | ...||.. | .
gnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelke.........aaleasekdevkealrqgfLald
SEINEGEEEL
..|.| ...|
eairelstdl
|
|||||||||
0034914 | PP2C-like | 26-526 | 2.2e-69 | 226.4 | In-house | 21-292 (295) | alignment | ||
Range on Protein: 26-526
Range on HMM: 21-292/295.0
CQYGTATMQGWRENMEDVITVVTDF---DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKA-------SVGYQDGDVSRGFCEAYMNCDRKLLTEDALKem
..|.|..||.|...|| ..||... .......|||||||| ... ..|..|. .|. . . . |. . . .|....|..||.. |.
lrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr..
klineseinegeeelngeesgdeverlteeahmpldkvlqaciedkkllkylinvanrnngdgsnddeisssdgegmaseeglggadniketqrsrvysq
....................................................................................................
fikelsvqykpalnelqtmmgedssegeeeeeeeeeeegpgegeteeegkpviannvrkrkrcdesdedlkdskrlkegrqemgqalgegggargegega
....................................................................................................
keegdgdeyhdSEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNM
.| ||.||.|.||. | |||||.||||.||..|| |.| |. |||| ..||||||..||| . . ||||.|..
...........pelagsGtTavvalirgnklyvanvGDSravllrng..............elvqltvdhkpvnelererilsaggavshg.rvngvlav
SRAIGDHMYKTNETLPLKDQMISAYPDVHTRLLQ-TQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNskkdlvLSHICEELCDACLAedidndGTGC
.||.||. .|.. .|.|.....||.|||... |. .|.||.|||||.|..|.....||... | . . |....|||.|..|| . ..
tRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld......leeaaeeLvdlAla......rgsr
DNMSIIITLLKP
||..... |..
DNiTvvvvrlng
|
|||||||||
0049733 | PP2C-like | 27-108 | 4.7e-12 | 39.0 | In-house | 4-81 (235) | alignment | ||
Range on Protein: 27-108
Range on HMM: 4-81/235.0
QYGTATMQGW-RENMEDVITVvtdfddKCSFLGVFDGHGGKEVSVYCSRHLPGFLKAS-VGYQDGDVSRGFCEAYMNCDRKLLT
..|.|...|. |...|| . | ......|.||||| ... ..|..|. .|.. .. |. . . .|.. ... ||
svgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaanealle
|
|||||||||
subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 27-104 | 3.7e-08 | 26.0 | In-house | 7-86 (255) | alignment | ||
Range on Protein: 27-104
Range on HMM: 7-86/255.0
QYGTATMQGWRENMEDVITVVTDFDDKC--SFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSRGFCEAYMNCDR
. | . | | | ||| ... | || .. .||||||.. . ..| .|. |. . .. . . . .|| . .
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeist
|
|||||||||
PPM_PTC7 | 28-105 | 3.2e-12 | 39.4 | In-house | 3-88 (259) | alignment | |||
Range on Protein: 28-105
Range on HMM: 3-88/259.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDG-DVSRGFCEAYMNCD--RK
.| .||.|..|||. .. .. .|. .|..||||||| |.. |.. ||...|| . ... ...... ......| .
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdee
|
|||||||||
PP2C | Protein phosphatase 2C | 28-110 | 7.8e-12 | 38.3 | Pfam-A | 3-92 (255) | alignment | ||
Range on Protein: 28-110
Range on HMM: 3-92/255.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDG-DVSRGFCEAYMN-CDRKLLTED
.| ..||.|..||| .. .. ... .|..||||||| |.. |.. ||...|| . ... .|.... ..... | .| ...
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelkssk
|
|||||||||
PP2C | Protein phosphatase 2C | 28-110 | 7.8e-12 | 38.3 | In-house | 3-92 (255) | alignment | ||
Range on Protein: 28-110
Range on HMM: 3-92/255.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDG-DVSRGFCEAYMN-CDRKLLTED
.| ..||.|..||| .. .. ... .|..||||||| |.. |.. ||...|| . ... .|.... ..... | .| ...
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelkssk
|
|||||||||
PPM_PTC7_SpoIIE | 28-105 | 2.2e-08 | 27.2 | In-house | 3-83 (230) | alignment | |||
Range on Protein: 28-105
Range on HMM: 3-83/230.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEvsVYCSRHLPGFLKASVgYQDGD-VSRGFCEAYMNCDRK
.| .||.|..|||. .. .. .. ..|..||||| . .....| ..|.. ..... .. . ... .....
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaad
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 29-108 | 4.4e-08 | 25.6 | In-house | 7-84 (263) | alignment | ||
Range on Protein: 29-108
Range on HMM: 7-84/263.0
GTATMQGWRENMEDVITVvTDFDDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVgYQDGDVSRGFCEAYMNCDRKLLT
|.....| |.. || |.. ...|.. ...|||||.| .. .| || .. |. . .|. ..|.||
GkdsliGkraenedrikl.keldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkr
|
|||||||||
subfamily_PPM1E_pd | Subfamily PPM1E | 30-109 | 1.1e-09 | 30.8 | In-house | 8-94 (265) | alignment | ||
Range on Protein: 30-109
Range on HMM: 8-94/265.0
TATMQGWRENMEDVITVVTDF--------DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLkASVGYQDGDVSRGFCEAYMNCDRKLLTE
.|.... | ||| .. |. ... .|..||||||| | . | ..||. .| .. . | . ..||. ..|...|.
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhell.vrqeklkedpaealkeafkltDerflqk
|
|||||||||
subfamily_ILKAP_pd | Subfamily ILKAP | 30-109 | 3e-08 | 26.2 | In-house | 9-103 (293) | alignment | ||
Range on Protein: 30-109
Range on HMM: 9-103/293.0
TATMQGWRENMEDVITVVTDFDD----------KCSFLGVFDGHGGKEVSVYCSRHLPG-----FLKASVGYQDGDVSRGFCEAYMNCDRKLLTE
| .| ||.|.|. ... |.|. . |. .|||||.|. | .....| . | .| .. .. . . ... . |...|..
yaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLkl
|
|||||||||
subfamily_PPM1L_pd | Subfamily PPM1L | 30-88 | 6.5e-08 | 25.1 | In-house | 9-69 (269) | alignment | ||
Range on Protein: 30-88
Range on HMM: 9-69/269.0
TATMQGWRENMEDVITVVTDFDDKC--SFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQD
. ...| |..||| ... .| ..| ||..|||||||. . .. |. .|. . |
vysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklield
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 31-106 | 1.1e-12 | 40.7 | In-house | 7-90 (309) | alignment | ||
Range on Protein: 31-106
Range on HMM: 7-90/309.0
ATMQGWRENMEDVITVVTDFDDK-----CSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGY---QDGDVSRGFCEAYMNCDRKL
.. || |. ||||...|.. ... .|..||||||||| . . ..|| ...| .. .. || . ||.... ...
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheam
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 36-163 | 1.8e-08 | 26.5 | In-house | 13-138 (492) | alignment | ||
Range on Protein: 36-163
Range on HMM: 13-138/492.0
WRENMEDVITVVTDFDDK--CSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSrgfceayMNCDRKLLTEDALKEMKLINESeINEGEEELNGE
|. .||| |.. .| .. .|.|..||. |. ....|. | . | || . .. .|. .. | . .| | ... . . |
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervs.......lttavnlidnndltdyeleras.rsdsirailke
ESGD----EVERLTEEAHMPLDKVLQACIEDKKL
|| . .|.. ..... ||..|. ||.. .
esvkpefekvkkAfrksylrldrlLsygieeesr
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 317-491 | 1.7e-19 | 62.9 | In-house | 162-319 (492) | alignment | ||
Range on Protein: 317-491
Range on HMM: 162-319/492.0
EEGDGDEYHDSEGHESGStATVCLIKTNILYVANAGDSRCVLSSNGERNHhhhhrylllgeavdLSLDHKPIDPLERERIERAGGHI---DEDLRVNGGL
|. . .. .. .|| . | |... .||.||||. . || .|. . | .| | .. ||.|.|.||. . .. .||| |
ekeekkdseeGlekesng.sevhleelgvlyianaGnvqAvLcreGkaii..............LtreHtprnkkERtRvekagsvvvkseknglvnGil
NMSRAIGDHmyktnETLPLKDQMISAyPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVR-NSKKDLVL
. | .| . . || .| . | ... |. ..||||||| |.|. |. ..|. .. | . . ... |
dttRGLGny.....GdpkLkksvipe.PkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvp
|
|||||||||
PP2C | Protein phosphatase 2C | 322-505 | 2.1e-50 | 164.7 | Pfam-A | 91-249 (255) | alignment | ||
Range on Protein: 322-505
Range on HMM: 91-249/255.0
DEYHDsEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylllgeaVDLSLDHKPIDPLERERIERAGGHIDEDLRVNGGLNMSRAIGD
.. .. | |||||.|.||. . |||||.||||.||..... . |. |||| |. ||||||.||| ... |||| |..|||.||
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.............keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGd
HMYKTNEtlplkDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRnskkdlVLSHICEELCDACLAE
. .| .| |..|| |||... |. .|.||.|||||.|..|..|..||... .| . . .. ..|||.| ..|
felkpke.....eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiar
|
|||||||||
PP2C | Protein phosphatase 2C | 322-505 | 2.1e-50 | 164.7 | In-house | 91-249 (255) | alignment | ||
Range on Protein: 322-505
Range on HMM: 91-249/255.0
DEYHDsEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylllgeaVDLSLDHKPIDPLERERIERAGGHIDEDLRVNGGLNMSRAIGD
.. .. | |||||.|.||. . |||||.||||.||..... . |. |||| |. ||||||.||| ... |||| |..|||.||
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.............keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGd
HMYKTNEtlplkDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRnskkdlVLSHICEELCDACLAE
. .| .| |..|| |||... |. .|.||.|||||.|..|..|..||... .| . . .. ..|||.| ..|
felkpke.....eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiar
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 324-476 | 3.4e-20 | 65.3 | In-house | 90-226 (263) | alignment | ||
Range on Protein: 324-476
Range on HMM: 90-226/263.0
YHDSEGHESGSTATVCLIKT-NILYVANAGDSRCVLSSNGErnhhhhhrylllgeAVDLSLDHKPIDPLERERIERAGGHID----EDLRVNGGLNMSRA
. ..| .||.||||.|.. . | .|. |||| .| ||. | |. ||.| |.||| .|||... . ..||| | |.|.
vaeaellssGttatvsllrdGtelvlaslGdsrailcrnGk..............akkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrs
IGDhmyktnetLPLKDQMISAYPDVHTR-LLQTQDQFLVLASDGIWNCLDSQQVVDFIN
.|| | || . | |. .. . ..| |||| .||| . ..||.. |...
lGd........ldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr
|
|||||||||
PP2C_SIG_SM00331 | 324-505 | 5.5e-13 | 42.0 | In-house | 78-204 (217) | alignment | |||
Range on Protein: 324-505
Range on HMM: 78-204/217.0
YHDSEGHESGSTATVCLI--KTNILYVANAGDSRCVLSSNGERNHHHHH-RYLLLGEAVDLSldhkpidplererieragghidedlrvngglnmsraig
|. .| .... |....|. ... |..|||||||..| .|.. ..... . .|| ...|
yeekeekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkdvegaplGlepevs......................................
dhmyktnetlplkdqmisayPDVHTRLLQTqDQFLVLASDGIWNCLDSQQ-----VVDFINAKLlevrNSKKDLVLSHICEELCDACLAE
.|.... |. . .|.|..||... ... . ... ... .| .. . ..| |||. . ..
....................vdirelelek.gdllllytDGltearsekgfaeerleeiledlv....dseaqelaqkiveellelakgs
|
|||||||||
PPM_PTC7 | 325-507 | 5e-49 | 160.1 | In-house | 95-255 (259) | alignment | |||
Range on Protein: 325-507
Range on HMM: 95-255/259.0
HDsEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylllgeaVDLSLDHKPIDPLERERIERAGGHID--EDLRVNGGLNMSRAIGDH
.. | |||||.|.|| . |||||.||||.||...|. . |. |||| .. ||||||.||| .. .. |||| |..|||.||.
nt.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav.............kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdf
MYKTNETlplKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVrnskkdlVLSHICEELCDACLAEDI
.| .|| . |..|| ||.... .. .|.||.|||||.|.....|..||... | . .. ..|.|.| ..| ..
elkpket...eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.......dpmeaaeklvdeaiargs
|
|||||||||
PPM_PTC7_SpoIIE | 325-482 | 1.9e-25 | 83.0 | In-house | 81-212 (230) | alignment | |||
Range on Protein: 325-482
Range on HMM: 81-212/230.0
HDSEGHE---SGSTATVCLIKTNI--LYVANAGDSRCVLSSNGERnhhhhhrylllgeavdlsldhkpidplERERIeRAGGHID---EDLRVNGGLNMS
.. . .| ||.||.|.|| . |||||||||...|...... ||||| ||| .. .. ||.| |..|
aadledepsssgaTavvalidpstgklyvanaGdsppllvrddgg...........................ereri.vagglpslGilpgrvfgvlavs
RAIGDHMYKTnetlplKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEV
.|.|| .. .|....| || . .| |.||.|||||.|..|..|..||.. |..
lapGdlllly......tDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp
|
|||||||||
subfamily_PPM1A_pd | Subfamily PPM1A | 326-524 | 3.3e-45 | 147.6 | In-house | 109-280 (282) | alignment | ||
Range on Protein: 326-524
Range on HMM: 109-280/282.0
DSEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDeDLRVNGGLNMSRAIGDHMYK
.. ..|||||...|.. . |..||.|||| ||..|| .|. |. ||||..| |..||| |||.. |||| | .|||.||. ||
lktadksGsTavtvlvsekhliianlGDsRavlcrng..............kaaflteDHkpsrpkEkkRieqAGGsvv.vsRvnGaLAvsRalGDyeyk
TNETLPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSKKdLvlshiCEELCDACLAEDidndgtGCDNMSIIITLL
..|... ..|..|| |.|.. ...|.|||||.|||| |....||.... .| . .. . ...| | .| .. ||.|... |.
eeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadelee.v.....akalvdkalekg......srDNlsvlvvlf
|
|||||||||
subfamily_PPM1E_pd | Subfamily PPM1E | 327-526 | 1.7e-29 | 95.8 | In-house | 97-264 (265) | alignment | ||
Range on Protein: 327-526
Range on HMM: 97-264/265.0
SEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGErnhhhhhrylllgeAVDLSLDHKPIDPLERERIERAGGHID--EDLRVNGGLNMSRAIGDHMY
.|. .||||| |.||... |||| |||. .| ..|| || | ||| .. |..||| ||| . . .|||| |..|||||| .
reklksGstavvvliekdqlyvaWlGDsqallvrkge..............avqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvkl
KtnetlplkdQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEvRNSKKdlvlSHICEELCDACLAEDidndgtGCDNMSIIITLL
| ...|. .|| . |. ....|.||.||.|. .. ..||. ... | . .... |.. ..|..| .. ||..... .|
k.........pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveeflad.gaedl....sevakllveaakeag......ssDnitvvvvfl
KP
.|
dp
|
|||||||||
subfamily_PPM1G2_pd | Subfamily PPM1G2 | 328-524 | 3.7e-54 | 176.6 | In-house | 111-286 (287) | alignment | ||
Range on Protein: 328-524
Range on HMM: 111-286/287.0
EGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGErNHHhhhryLllgeavdlSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNMSRAIGDHMYKTN
. ...||||.| ||| . ||||||||||.||||.|. . | |.|||| . |..||. ||| .. . |||| | .|||.||...|.|
kdesaGstavvvlikeeklyvanaGDsravlsskgn.vka.....l........sfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkkn
ETLPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNskkdlvLSHICEELCDACLAEDIDNDGTGCDNMSIIITLL
.... ..|.. |.||| .. |. .| ||||| ||||..| ...|||... .| . .. |..|.||| | |||.| .| | |||||...| |
vkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgak......ldeiieelldkclapdssntgvGcDnmtvvivvl
|
|||||||||
0049733 | PP2C-like | 328-524 | 1.1e-35 | 116.2 | In-house | 88-233 (235) | alignment | ||
Range on Protein: 328-524
Range on HMM: 88-233/235.0
EGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIdedlRVNGGLNMSRAIGDHMYKtn
| . .|.||.|.|. .. |||||.||||..| ..| ..| |. ||.| ..|||.||..|||.. ||.|.| ..||.||...|
elagmgtTavvalldggklyvanvGDsrayllrdg..............klvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllk..
etlplkdqmisayPDVHTRLLQTQDqFLVLASDGIWNCLDSQQVVDFINAkllevrnskkdLVLSHICEELCDACLAedidndGTGCDNMSIIITLL
|||.. |. .| ||.|||||.|..|.....||... | |....|.|....|| . |.||..... |
.............pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs...........ldleeaaerlvelala......rggrDNiTvvvvrl
|
|||||||||
subfamily_Choan-PPM1K-like_pd | Subfamily Choan-PPM1K-like | 329-422 | 2.1e-14 | 46.8 | In-house | 81-183 (292) | alignment | ||
Range on Protein: 329-422
Range on HMM: 81-183/292.0
GHESGSTATVCLIKTNI--LYVANAGDSRCVLSS--NGERNhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHID----------EDLRV-----
||..||.|| . . |..|| ||||..| | .. | . || |||| || ||.|| ||||... ||
aresattavvcarvrddralilanvGdsrallgrclggsdy...........eliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrq
-NGGLNMSRAIGDH
.|.| .|||.||
qeGdlalsralGdf
|
|||||||||
subfamily_PPM1L_pd | Subfamily PPM1L | 330-492 | 8.3e-27 | 87.1 | In-house | 104-249 (269) | alignment | ||
Range on Protein: 330-492
Range on HMM: 104-249/269.0
HESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllGEAVDLSLDHKPIDPLERERIERAGGHID--EDLRVNGGLNMSRAIGDHmyktn
...|.|| . |.. . | ||| |||| || . |.|. || |||| .. || ||..||| | ||.| | .|||.||.
diaGttalialvqesdlivanvGdsrGvlydkr.............GkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdy.....
etlPLKDQ-MISAYPDVHTR-LLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSKKDLVLS
||||. .. | ||. | | . . .||.|||||.|... .. | || .| | | |||
...plkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvle
|
|||||||||
subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 330-476 | 1.5e-26 | 86.2 | In-house | 93-221 (255) | alignment | ||
Range on Protein: 330-476
Range on HMM: 93-221/255.0
HESGSTATVCLIKTNILYVANAGDSRCVLSsngernhhhhhryLLLGEAVDLSLDHKPIDPLERERIERAGGHIDED---LRVNGGLNMSRAIGDHMYKt
|.||.. || . |.|| |||| ||. | |. ||||||| .. |..||...|| . .. |||| | .|||.|| .
kfiGttaasvliiedkvyianvGdsrvvlc.............qkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle.
netlPlkdqMISAYPDVH-TRLLQTQDQFLVLASDGIWNCLDSQQVVDFIN
| . . ||.. . ...|.||.|| ||||. . .. |. .
....P....fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiva
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 330-397 | 2.9e-08 | 25.9 | In-house | 160-211 (404) | alignment | ||
Range on Protein: 330-397
Range on HMM: 160-211/404.0
HESGSTATVCLIKTNILYVANAGDSRCVLSSNGERnhhhhhrylllgeaVDLSLDHKPIDplERERIE
. | || | |. .. |||||||||| .|. ..| ..|| |. | ||.|.
ikGGCtalvalvllgklYvanaGDsRailvrkdei..............iplsadftPet..eRqRlq
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 331-525 | 2.2e-24 | 79.1 | In-house | 107-308 (309) | alignment | ||
Range on Protein: 331-525
Range on HMM: 107-308/309.0
ESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylLLGEAVDLSLDHKPIDPLERERIERAGGHIDED------------LRVNGG------
.|.||.| .|. . ||||. |||. ||... ... .| | |||| .| |.||||..||.. . |. ||
taGttasvviirreklyvahvGDsaivlgvkepke........kklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvidei
--LNMSRAIGDhMYKTNETlpLKDQMISAYPDVHTRLLQTQDQ-FLVLASDGIWNCLDSQQVVDFINAKLLEVRNS-KKDlvlSHICEELCDACLAEdID
|...|..|| .. |.. . ..| ||| | |..... |..|||||.||.| ....|.... . ... ... . | . | .
PFLavaRslGD.lWsynak..sgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs...rsvakalvkealqr.wr
NDGTGCDNMSIIITLLK
. .||.|.|. .|.
skklraDnvsvivvile
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 331-485 | 2.8e-21 | 69.1 | In-house | 151-318 (398) | alignment | ||
Range on Protein: 331-485
Range on HMM: 151-318/398.0
ESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNHHhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDE-----DLRVNGGLNMSRAIGDHMYK
||..|.. ||. . |.|||.||.|.|| .. |. . ||| || |. . | |||... . .. . |. | | .|| || ||
lsGacallaliegtelhvAntGDcravlgvqeeegsw.........eavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryK
TNET---LPLKD---Q-----------MISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNS
.| .|.. . ..| |.| .. |...|.|||||.||.|..|....||. .. | . ..
wseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkek
|
|||||||||
subfamily_ILKAP_pd | Subfamily ILKAP | 332-487 | 2e-32 | 105.5 | In-house | 113-250 (293) | alignment | ||
Range on Protein: 332-487
Range on HMM: 113-250/293.0
SGSTATVCLIKTNILYVANAGDSRCVLSSNGERNHHhhhrylllGEAVDLSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNMSRAIGDHMYKTNEtlp
||||||.|. |.||||| |||..|| . | .. .| |. ||.|.. ||.||..|||.. .. ||.| |..||.||| .|.
dGstatvvlvldnvlyvanlGdskavlvrkkeegdk........iasvvLtkdhtpvkyeerkriqkaGgvvrdg.rvlGvlevsrsiGdgrfkrlG...
lkdqmISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVrNSKK
... |||. |. |.|.||| ||.|. .. ..||.||.. | . ....
.....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvlede.eddr
|
|||||||||
subfamily_KAPP-like_pd | Subfamily KAPP-like | 332-477 | 2.8e-17 | 55.6 | In-house | 100-230 (266) | alignment | ||
Range on Protein: 332-477
Range on HMM: 100-230/266.0
SGSTATVCLIK----TNILYVANAGDSRCVLSSNgErnhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDE-DLRVNgGLNMSRAIGDHMYKT
|.|||..|. | ||| ||| || . |.. || ||| || |. || | . . . |.| || .|||.|||. |
eGatatlalvwsdGqqrylqvanvGdssaflsrG.n.............eslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfike
NETlplkdqMISAYPDVHTRL-LQTQDQFLVLASDGIWNCLDSQQVVDFINA
. ... | | |. | .|.||..||||.|. .. .. .. ...
lni......GlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvks
|
|||||||||
subfamily_Dicty-PPM-1_pd | Subfamily Dicty-PPM-1 | 332-477 | 3.4e-17 | 55.2 | In-house | 104-240 (276) | alignment | ||
Range on Protein: 332-477
Range on HMM: 104-240/276.0
SGSTATVCLIKTNILYvANAGDSRCVLSSNGERNhhhhHRYLLLG-EAVDLSLDHKPIDPLERERIERAGGHIDE-DLRVNgGLNMSRAIGDHMYKTNET
|.|||..|. .. . . | . ..| .| | |.. || ||| || |..|| | . . . |.| || .|||.|||. | .
eGatatlalvwsdGee.qqqqqqrylqvanvGds....saflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikelni
lplkdqMISAYPDVHTRL-LQTQDQFLVLASDGIWNCLDSQQVVDFINA
... | | |. | .|.||..||||.|. .. .. .. ...
......GlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvks
|
|||||||||
subfamily_TAB1_pd | Subfamily TAB1 | 332-498 | 1.7e-14 | 46.3 | In-house | 129-295 (333) | alignment | ||
Range on Protein: 332-498
Range on HMM: 129-295/333.0
SGSTATVCLIKTNILYVANAGDSRCVLSSNGErnhhhhhryllLGEAVDLSLDHKPIDPLERERIERAGGHIDED--LRVNGGLNMSRAIGDHM----YK
|.|| | || | |||||.|||| .| . | . . || ||. . | .|... | |.. .. |. . |.|||. ||
gGttAvvalifnnkLyVaNvGdsrAllvkrke...........sekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgyk
TNETLP-LKDQMISAYPDVHTR-LLQTQDQFLVLASDGIWNCLDSQQVVDFINAK--LLEV-RNSKKDLVLSHICEEL
.. | |.. . | ||.. .. .|||| |||. ..|. . . | . |||| . .|. |. . ...
dvdilssakgePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqav
|
|||||||||
subfamily_Choan-PPM-1_pd | Subfamily Choan-PPM-1 | 332-512 | 1.1e-06 | 20.1 | In-house | 134-309 (317) | alignment | ||
Range on Protein: 332-512
Range on HMM: 134-309/317.0
SGSTATVCLIKTN-ILYVANAGDSRCVLSSNGERNHHHHHRYLLlgEAvdLSLDHKPIDPLERERIERA---GGHIDEDLRVNGGLNMSRAIGDHMYKTN
|.||.| .. . . ||||||. ... . .| . . . || || |. ||.|.. . .|. || . . .| . |.
fGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsv..ea..lsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltksl
ETLPLKDQMISAYPDVHTRLLQTQDQFLVLA-SDGIWNCLDSQQVVDFINAKLLEVRNSkkdlvlSHICEELCDACLAEDIDNDGT
|| ..| |.|..| |.... | |.. |||| . | ..|.| . | .|.. | .|.|. .| |
GhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleas......evlcddaqdylldetsiddat
|
|||||||||
subfamily_PHLPP_pd | Subfamily PHLPP | 388-478 | 2.6e-09 | 29.3 | In-house | 134-215 (246) | alignment | ||
Range on Protein: 388-478
Range on HMM: 134-215/246.0
IDPLERERIERAGGHIDEDLRVNGGLNMSRAIGdHMYKTNETLPlkdqmisaYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAK
|. | .|| | . |.|| ..|| .. .| .| ... || | |. ||..|| .|.. .. .|. |. ...|. . .
iekdelkrikeakaiitednkingviestrllG.ytflfPvvlP........kphvrevlLteqdellivGnkalWevlsideaveavrke
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 392-487 | 1.3e-11 | 36.9 | In-house | 182-271 (305) | alignment | ||
Range on Protein: 392-487
Range on HMM: 182-271/305.0
ERERIERAGGHIDE--DLRVNGGLNMSRAIGDHMYKTNETlPLKDQMISAypdvhtrLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSKK
.| ||| ... . . .|.||. |. || .|| | | .|. . . ...||||||| ||.|. |. |.||......| . .||
iririeslqaalynygellvnrllkksrskGdknlkelvi.Pnndspllv.......vakanDqflvlatdGlwevlsyqdvveevkellrdkssqkk
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 408-485 | 1.3e-09 | 30.3 | In-house | 276-357 (404) | alignment | ||
Range on Protein: 408-485
Range on HMM: 276-357/404.0
RVNGGLNMSRAIGDHMYKTNE-TLPLKdQMISAYPDVHTRLLQ----TQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNS
|. . . ..| .||| |. . .| .| ..|. |.|... |. ..|. |.||.||.|. |. ..| .. | .| ..
RllatigvtRGlGDheLkvvdtnlsik.PfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepe
|
|||||||||
PPM_PTC7_SpoIIE_motif | 453-521 | 8.7e-06 | 19.3 | In-house | 13-77 (81) | alignment | |||
Range on Protein: 453-521
Range on HMM: 13-77/81.0
QFLVLASDGIW-------NCLDSQQVVDFINAKllevrnSKKDlvLSHICEELCDACLAediDNDGTGCDNMSIII
|.|..||.. .... ......... ..|. | .....|.|..|. ..| |......
dvllLyTDGltEardsdgelfgkeellrladra......egks..lqeladklvdevle...ngsgereDDitllv
|
|||||||||
PPM_PTC7_motif | 456-506 | 3.6e-11 | 36.4 | In-house | 1-46 (51) | alignment | |||
Range on Protein: 456-506
Range on HMM: 1-46/51.0
VLASDGIWNCLDSQQVVDFINAKLLEVRNskkdlVLSHICEELCDACLAED
.|||||.|..|..|..||... | . .. . ..|.|.| .||.
iLAsDGLWDvlsdqeavdlvrdqlskkgl.....spqeaAeklvdealarg
|