Gene TAB1-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily TAB1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP216_AA protein Get Run
AqueP216_AA_36-362 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_TAB1_pd Subfamily TAB1 20-362 1.4e-151 497.0 In-house 2-331 (333) alignment 
Range on Protein: 20-362
Range on HMM: 2-331/333.0
IENARYSieaeskvmssFPDHTNEDKCFILtprSTQDDPIIMAVFDGHDGSKGSTLAEGMLYSRFINPDVLDEL-KANPMETLNQLILETEKKFFREIRN
..| |||           .||..|||.|..   .|..|||..|||||.||.|.....| .|..........||| .|...|.|.... |.|.||...|..
vsnrrys..........kedhevedkvflf...ktendpilyavFdGydGnkaakfveqrLvaellleqltdelaeaevkevlkrafeeverkflesidd

FVEEKDDILGTLPKGVTSYEAYILYPEKINRLQEIEPELAGGTTAVIAVVFNNNLYVANVGDSRAIAVY---KDQHKQLSVDHGVDNEDELKRLKDLGLD
...||||.  .||.||.|||.. .|||||.||||.|.|..||||||.|..|||.|||||||||||..|.   ....||||||| .||||||.||||||||
alaekddlqsqlPegvssyeleeqypekierlqeleeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGld

IEQIKRNGRLGSHENTRSIGDYNIKIGYKDVDVLSSATGPPGIAIPSINGPYPINDIEY-ILLMSDGVYKTLEYLTDPPTSDVYPRLLQLIQEAEKSVDL
|||||||.||||.|||||||||..|.||||||.||||.|.|.|| |.|.|.|||.||.| ..|||||||||||..|.|.||.|...||..|.|.||...|
ieqikrnkrlgskentRsiGdykvkkgykdvdilssakgePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatl

QDIANKVLQDIKISHEVVYYDSAmtdprSTVAVNCRKRDDMTLIVLKF
||.|..|....|..|. .|..||     |..||.|||||||||.||||
qdvAqavvdkvkrkHkdaylssa.....seravicrkrddmtllvlkf
0034914 PP2C-like 37-362 1.5e-40 132.0 In-house 31-290 (295) alignment 
Range on Protein: 37-362
Range on HMM: 31-290/295.0
FpDHTNEDKCFILTPRST-QDDPIIMAVFDGHDGSKGSTLAEGMLYSRFIN-----PDVLDELKANPMETLNQLILETEKKFFREIRNFveekddilgtl
   ..||| ......  . ..| ....||||| |.. . .|  .|.. ...        |..   ...| | . .|.............           
r.rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr...........

pkgvtsyeayilypekinrlqeiEPELAGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHKQLSVDHGVDNEDELKRLKDLGLDIEQikrNGRLGSHEN
                          . .|||||.|....| |||||||||||. . .....||.||| ..||.| .|....|  .     . ..|.   
.......................pelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlav

TRSIGDYNIKIGYKDvdvlsSATGPPGIAIPSINgPYPI--NDIEYILLMSDGVYKTLEyltdppTSDVYPRLLQLIQeaeKSVDLQDIAN-------Kv
||..||.. |. ...      ...|. .|.| .   ...  .| ...||.|||....|.       ....  . .|..   |. ||...|.       . 
tRalGdfdlklllsl.....llleplvsaePdvt.vleltledddfllLasDGlwdvls......neeivdivrslla...kgldleeaaeeLvdlAla.

lqdikishevvyydsamtdprstvavnCRKRDDMTLIVLKF
                           . .||..| .|...
...........................rgsrDNiTvvvvrl
0049733 PP2C-like 38-362 1.2e-30 99.7 In-house 14-233 (235) alignment 
Range on Protein: 38-362
Range on HMM: 14-233/235.0
PDHTNEDKCFIltprstqdDPIIMAVFDGHDGSKGSTLAEGMLYSRFINPdVLDELKANPMETLNQLILETEKKFFREirnfveekddilgtlpkgvtsy
 ...||| ...        . ...||.||| |. .. .| ..|.. ...  .|. |  ...| | . .|.... ....                      
vrkvneDavlv........glllfavaDGhgghaagevasellvetllel.llelllldleealrkaflaaneallel......................

eayilypekinrLQEIEPELAGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHKQLSVDHGVDNEDELKRLKDLGLDIeqikrnGRLGSHENTRSIGDY
             .. ..   .|||||.|..... |||||||||||. . ...  ||..|| . ||.| .|....|  .        .|..  ||..||.
............alaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdl

NIKigykdvdvlssatgppgiaiPSINgPYPINDIEYILLMSDGVYKTleyL---------TDPPTSDVYPRLLQLIQEaeksvdlqdiankvlqdikis
 .|                    | .   ..... ...||.|||...    |         .. . ...  ||..|  .                     
llk....................pdvt.vlelepgdflllasDGlwdv...lsdeeivdllrsldleeaaerlvelala.....................

hevvyydsamtdprstvavnCRKRDDMTLIVLKF
                      .||..|..|...
....................rggrDNiTvvvvrl
PP2Cc_SM00332 40-359 2e-35 115.5 In-house 22-273 (274) alignment 
Range on Protein: 40-359
Range on HMM: 22-273/274.0
HTNEDKCFILTPRSTQDDPIIMAVFDGHDGSKGSTLAEGMLYSRFINPDV--LDELKANPMETLNQLILETEKKFFREIRNFVEEKddilgtlpkgvtsy
...|| ... .  . ..|  ...||||| ||. . ..   |.. ...     .|||. .. | |.. .|.|....  | ..  .|.              
ksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen..............

eayilypekinrlqeiepeLAGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHKQLSVDHGVDNEDELKRLKDLGLDIEQIkrnGRLGSHENTRSIGDY
                      |.|||.|.. ...|||||||||||. . .....|||||| ...|||.||.|. |  .|.       |. . .|..||.
...................alsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdh

NIK--IgykdvdvlsSATGPPGIAIPSINGPYPINDIEYILLMSDGVYKtleyltdPPTSDVYPRLLQLIQEAEKSVDLQDIANKVLQ----Dikishev
  |  .         . . |  .| |...     .. | ..|.|||..         ....    ... . . .|  | |..|... .    .       
flkknk.........klkepyitaepdvkvvtltsedeflilaSDGlwd.......vlsnqevvdivrkllakgktndpqeaaelldeeairr.......

vyydsamtdprstvavnCRKRDDMTLIV
                  ...|..| .|
.................ggseDniTvvv
PP2C Protein phosphatase 2C 40-288 1.1e-30 100.1 Pfam-A 13-218 (255) alignment 
Range on Protein: 40-288
Range on HMM: 13-218/255.0
HTNEDKCFILTPR---STQDDPIIMAVFDGHDGSKGSTLAEGMLYsrfinpDVLDELKANPMETlnqliletekkffreirnfveekdDILG--------
...||....| .    | ...  ..|||||| |.. ...|. .|       ..|.| |  .  .                        .           
ksmedahialknlekssgkssvaffavfdghggreaakyarehle......eilkeqksflele........................kvekalrksfla

-------TlpkgvtsyeayilypeK-INrlqeiEPELAGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHK-QLSVDHGVDNEDELKRLKDLGLDIEQi
       .                .  |     . ..  |.|||.|......|||||||||||. . ||. | .|..|| ...||| .|....|  ... 
dtdeelks................skan.....tepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn.

krNGRLGSH-ENTRSIGDYNIKIGYkdvdvlssatGPPGIAIPSINGPYPINDIEYILLMSDGVYKTLEY
  |||.    ...|..||. .| ..           .. .| | ..     .. |...|.|||..  |..
..ngrvngsLavsRalGdfelkpke..........eqlvsaePdvtsvklteedefliLasdGlwdvlsd
PP2C Protein phosphatase 2C 40-288 1.1e-30 100.1 In-house 13-218 (255) alignment 
Range on Protein: 40-288
Range on HMM: 13-218/255.0
HTNEDKCFILTPR---STQDDPIIMAVFDGHDGSKGSTLAEGMLYsrfinpDVLDELKANPMETlnqliletekkffreirnfveekdDILG--------
...||....| .    | ...  ..|||||| |.. ...|. .|       ..|.| |  .  .                        .           
ksmedahialknlekssgkssvaffavfdghggreaakyarehle......eilkeqksflele........................kvekalrksfla

-------TlpkgvtsyeayilypeK-INrlqeiEPELAGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHK-QLSVDHGVDNEDELKRLKDLGLDIEQi
       .                .  |     . ..  |.|||.|......|||||||||||. . ||. | .|..|| ...||| .|....|  ... 
dtdeelks................skan.....tepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn.

krNGRLGSH-ENTRSIGDYNIKIGYkdvdvlssatGPPGIAIPSINGPYPINDIEYILLMSDGVYKTLEY
  |||.    ...|..||. .| ..           .. .| | ..     .. |...|.|||..  |..
..ngrvngsLavsRalGdfelkpke..........eqlvsaePdvtsvklteedefliLasdGlwdvlsd
subfamily_PPM1A_pd Subfamily PPM1A 40-287 1.7e-24 79.6 In-house 24-235 (282) alignment 
Range on Protein: 40-287
Range on HMM: 24-235/282.0
HTNEDKCFILTPRSTQDDPIIMAVFDGHDGSKGSTLAEGMLYSRFINPDVLDE--LKANPMETLNQLILETEKKFFREIRNFVEEKDD---Ilgtlpkgv
 ..||.  . .  ... |    |||||| ||. .. .. .| .  .. . | |  |.|.. ..... . .   ..  .||.  ....             
vemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlktadks........

tsyeayilypekinrlqeiepelagGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHKQLSVDHGVDNEDELKRLKDLGLDIEQIKRNGRLGsheNTRSI
                         |.||| ..| ...|..||.|||||. . . . . |. ||  ....| ||... |  .   . || |     .|..
.........................GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLA...vsRal

GDYNIKIGYKDVDVLSSATGPPGIAIPSIngpypINDIEYILLMSDGVYKTLE
|||..|   .        .. | ... ..     ... ....| .||.. .|.
GDyeykeeeekkaeeqlvsaepevtsier.....seeddflvlacDGiwDvls
PPM_PTC7_SpoIIE 40-361 1.1e-19 64.1 In-house 13-228 (230) alignment 
Range on Protein: 40-361
Range on HMM: 13-228/230.0
HTNEDKCFILTPR---STQDDPIIMAVFDGHDGSKgsTLAEGMLYsrfinpDVLDELKANPMETLNQLILETEKKFFREIRNFveekddilgtlpkgvts
...||..... .    | ..  .. ...||| |.   .|| |.|       ..|.||. . .|...... ... .........                 
ksmedahispansekssggrlalvvgdvdGhGgra..alamgllr......talrelafaglekpeeilrrlnlalaadlede.................

yeayilypekinrlqeiepELAGGTTAVIAVVFNNN--LYVANVGDSRAIAVYKDQHkqlsvdhgvdnedELKRLkDLGLDIEqI--KRNGRLGSHENTR
                   .  .|.|||.|......  |||||.|||... | .|..             | .|. ..|  .. .    .   |... ..
...................psssgaTavvalidpstgklyvanaGdsppllvrddgg.............ereri.vagglps.lGilpgrvfgvlavsl

SIGDYNIKIgykdvdvlssatgppgiaipsingpypindieyillmSDGVYKTLEYltdPPTSDVYP--RLLQLIQEA-EKSVDLQDIANKVLQDIKISh
..||. ..                                      .|||     .    ..   .   ..|.|. ..    ...|... .|.....   
apGdlllly.....................................tDGvveaepd...tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.

evvyydsamtdprstvavNC--RKRDDMTLIVLK
                  ..  ...||.||.|..
..................aaeglleDDitllvvr
subfamily_PPM1E_pd Subfamily PPM1E 40-115 6e-06 18.6 In-house 16-94 (265) alignment 
Range on Protein: 40-115
Range on HMM: 16-94/265.0
HTNEDKCFILTP-----R-STQDDPIIMAVFDGHDGSKGSTLAEGMLYSRFINPdvlDELKANPMETLNQLILETEKKFFRE
.. ||.. .|         . ...   .|||||| |.. .. |   |..  ..     .|| .|.| |.. . .|...| . 
rkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrq...eklkedpaealkeafkltDerflqk
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 41-237 9.4e-16 50.8 In-house 19-175 (255) alignment 
Range on Protein: 41-237
Range on HMM: 19-175/255.0
TNEDKCFILTPRSTQDDPIIMAVFDGHDGSKGSTLAEGMLYSrfINPDVLDELKANPMETLNQLILETEKKFfreirnfveekddilgtlpkgvtsyeay
| ||.  |      ..|  ..|.|||| |.. .. |   ||   |  ..||  .|||...|..   |.. ..                            
tmedelviyGsfrdksdedyyalfdGhgGraaakfaseelyk..ilaelldlnnanPvkslkkaykeistqi............................

ilypekinrlqEIEPeLAGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQ-HKQLSVDHGVDNEDELKRLKDLGLDIEQIKRNGRL-GSHENTRSIGDY
           .  |    ||||. ... ..  |.|||||||..   ||   |.||.||   .|.| ||...||  . . .   |. |    .|..|| 
...........serp.kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds
subfamily_PPM1K_pd Subfamily PPM1K 41-240 2.8e-14 45.9 In-house 17-182 (263) alignment 
Range on Protein: 41-240
Range on HMM: 17-182/263.0
TNEDKCFILtprSTQDDPIIMAVFDGHDGSKGSTLAEGMLYSrFINpDVLdELKANPMETLNQLILETEKKFFREIRNFVEEKddilgtlpkgvtsyeay
 |||.  ..     ... . .|||||| ||     .   |    .. ..| |   .  . |..  .| .||. | ..  | |.                 
enedriklk...eldpellyvavfdGhaGsaaadfvhdklek.ilk.rll.ekekdleivlknafeeldkklkrylefsvaea.................

ilypekinrlqeiePELAGGTTAVIAVVFN-NNLYVANVGDSRAIAVYKDQHKQLSVDHGVDNEDELKRLKDLGLDIE-----QIKRNGRLgshENTRSI
               .|. |||| .... . ..| .|..||||||   . . |.|. ||  . |.| .|.|  |  .|     . . ||||     |||.
..............ellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrl...amtrsl

GDYNIK
|| ..|
Gdldlk
subfamily_PPM1H_pd Subfamily PPM1H 42-213 2.6e-18 59.0 In-house 42-214 (404) alignment 
Range on Protein: 42-213
Range on HMM: 42-214/404.0
NEDKCFILTPRSTQD----DPIIMAVFDGHDGSKGSTLAEGMLYSRFIN--PDVLDELKANPMETLNQLILETeKKFFREIRNFVEEKDDILGTLPKGVT
...|    .|....     .  . ..|||| ||  ...|  .| ..  .   |||. |...  |. ..   .. |.     .. .|||.    .| .|  
kkeksvtskpkekseeeklplayfglfDGhaGsgaalvaskllhkhlkekledvlellleksaeeeenteess.kespssvseiyeekeiskeeLviGal

SyEAYILYPEKINRLQEiEPELAGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHKQLSVDHGVdnEDELKRLKDLG
  .|..   |.|.| .| . ...|| ||..|.|... ||||| |||||| | ||. ..|| |.    | | .||. |.
e.saflemDeqiarere.ayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftP..eteRqRlqela
subfamily_PPM1L_pd Subfamily PPM1L 42-240 1.9e-14 46.6 In-house 19-188 (269) alignment 
Range on Protein: 42-240
Range on HMM: 19-188/269.0
NEDKCFILTPRSTQDDPIIMAVFDGHDGSKGSTLAEGMLYSRFINpDvLDELKANPMETLNqliletekkffreirnfveekddilgtLPKGVTSYEAYI
 ||.  | .  . . .. ..|||||| |   .  |. .|     |   | ||.|.  .|.                            .  .    .  .
medrfeieediknktgesffavfdGhGGefaaefakdvlvkaikn.k.lieldadkentep...........................infsklltdeil

LYPEKINRLQEIEPELAgGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQ-HKQLSVDHGVDNEDELKRLKDLGLDIEQIKRNGRLGSHENTRSIGDYNIK
   ||.    . . ..| ||||.||.| ...| |||||||| . . |.     || ||   .  | ||.|. |  |         |    .|..||| .|
svdekllekakraedia.GttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk
PP2C_2 Protein phosphatase 2C 42-306 1.6e-09 30.4 Pfam-A 12-199 (212) alignment 
Range on Protein: 42-306
Range on HMM: 12-199/212.0
NEDKCFiltPRSTQDDPIImAVFDGHDGSKGSTLAegmlySRFINPDVLDELKANPmetlNQ----LiletEKKFFREIRNFVEE--Kddilgtlpkgvt
..|...    |...|  .. || ||.   |.|  .     .|.    ... |...     ..         |....|.|.| ...  |            
cqDala...ireasdgwll.aVADGaGsakrSdkG.....arlaveaagealekll....eeeseqe....eeallrqieneilasvk............

syeayilypEKINRLQEIEPELAGGTTAVIAVVFNNNLYVANVGDSRAIAVY-KDQHKQLSVDHGVDNEDELKRLKDLGLDIEQikrngrlgshentrsi
          | .. .. |.  . .|| ..||. .........||......   .. ..|. ..  . . |. .|..     |                 
.........lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel................

gdynikigykdvdvlssatgppgiaipsI--NGPypINDIEYILLMSDGVYKTLeyLTDPPTSDVYPRLLQLIQ
                               ...   .... .|||.||| . |   ...|  ... .||. ..
............................rirrlk..lepgdalllmTDGvsdsl..rkeepfrellaelletle
PP2C_2 Protein phosphatase 2C 42-306 1.6e-09 30.4 In-house 12-199 (212) alignment 
Range on Protein: 42-306
Range on HMM: 12-199/212.0
NEDKCFiltPRSTQDDPIImAVFDGHDGSKGSTLAegmlySRFINPDVLDELKANPmetlNQ----LiletEKKFFREIRNFVEE--Kddilgtlpkgvt
..|...    |...|  .. || ||.   |.|  .     .|.    ... |...     ..         |....|.|.| ...  |            
cqDala...ireasdgwll.aVADGaGsakrSdkG.....arlaveaagealekll....eeeseqe....eeallrqieneilasvk............

syeayilypEKINRLQEIEPELAGGTTAVIAVVFNNNLYVANVGDSRAIAVY-KDQHKQLSVDHGVDNEDELKRLKDLGLDIEQikrngrlgshentrsi
          | .. .. |.  . .|| ..||. .........||......   .. ..|. ..  . . |. .|..     |                 
.........lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel................

gdynikigykdvdvlssatgppgiaipsI--NGPypINDIEYILLMSDGVYKTLeyLTDPPTSDVYPRLLQLIQ
                               ...   .... .|||.||| . |   ...|  ... .||. ..
............................rirrlk..lepgdalllmTDGvsdsl..rkeepfrellaelletle
subfamily_PPM1G2_pd Subfamily PPM1G2 52-286 4e-24 78.0 In-house 46-234 (287) alignment 
Range on Protein: 52-286
Range on HMM: 46-234/287.0
RSTQDDPIIMAVFDGHDGSKGSTLAEGMlysrfinpdvldelkanpmetL-----NqliletekkffreirnfveeKDDIL-GTLPKGVtsYEAYILYPE
.| ...  ..|||||| |.| .  |                        |     .                    |..   |.| . .   .|..   |
ksddkslalfavfDGhGGakvakyagkk.....................likkiak....................kksfkegaleqil..kdafletDe

KINRLQEIEPELAgGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHKQLSVDHGVDNEDELKRLKDLGLDIEQIKRNGRLGShenTRSIGDYNIKIGYKD
.. . .... | | |.|||.... ...|||||.|||||..  | . |.||.||  ..|.| ||... |  .|  . || |      |..||.. | . | 
ellkdeklkdesa.GstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLal...sralgDfefkknvkk

VDVLSSATGPPGIAIPSINgpypiNDIEYILLMSDGVYKTL
       |  | . . ...     .| |...|  ||..  |
kpeeqivtavPDvlvkkld.....eddeflvLaCDGiWDvl
PP2C_SIG_SM00331 54-362 6e-09 28.8 In-house 26-217 (217) alignment 
Range on Protein: 54-362
Range on HMM: 26-217/217.0
TQDDPIIMAVFDGHDGSKGSTLAegmlySRFINPDVLDELKANpmetlnqlilETEKKFFR--------Eirnfveekddilgtlpkgvtsyeayilype
.... ....|.||... . . .|     |. . . .  .|...          |. .....        |                              
lnegrlllvvaDgmGkGlaAaaa.....ssqlrtalrellseg..........eelsqalkrlnraiyee..............................

kinrlqeiEPELAGGTTAVIAVV--FNNNLYVANVGDSRAIAVYkDQHKQLSVDHgvdnedelkrlkdlgldieqikrngrlgshentrsigdynikigy
        . |  ...|...|..   ...|..||.|||| . .  |.. .  ...                                             
........keekgmfaTlllalydfssgklsyanaGdsrpyllr.dgklveilkd.............................................

K-----------DvdvlssatgppgiaIPSINGPYPINDIeyILLMSDGVYKTLEYLTdPPTSDVYPRLLQLIqeaekSVDLQD----IANKVLQDIKIS
.           .              . . .  .   |.  .||..||.    .  .   . ..   | .|      .  .|.    | ...|. .| |
vegaplGlepevs..............vdirelelekgdl..lllytDGltearsekg.faeerleeiledlv.....dseaqelaqkiveellelakgs

HEvvyydsamtdprstvavncrkRDDMTLIVLKF
.                      .||.|..|.|.
ng.....................eDdiTvvvvkv
PPM_PTC7 114-288 2.7e-32 105.2 In-house 54-223 (259) alignment 
Range on Protein: 114-288
Range on HMM: 54-223/259.0
REIRNFVEEKDDILGT-LPKGVTsYEAYIL-YPEKI------NrlqeiEPELAGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHK-QLSVDHGVDNED
  . ....|. .   . ... .  ....   . ..       |     . .. .|.|||.|......|||||||||||. . ... . ||..|| ..|||
ehleeilkerksfeeleklekal.rksflaldtdeelkssean.....tepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsned

ELKRLKDLGLDIEQIkRNGRLGSH-ENTRSIGDYNIKIGYKdvdvlssaTGPPGIAIPSINGPYPINDIEYILLMSDGVYKTLEY
| .|....|  .... .|||.    ...|..||.  |....        . .. .| | |.     .. |...|.|||..  ...
EreRiegaggsvsnv.gngrvngvlavsRafGdfelkpket........eeqlvsaePdisstkideedefliLasdGlwdvvsd
subfamily_KAPP-like_pd Subfamily KAPP-like 151-241 2.1e-10 33.1 In-house 88-184 (266) alignment 
Range on Protein: 151-241
Range on HMM: 88-184/266.0
QEIEPEL----AGGTTAVIAVVFNN----NLYVANVGDSRAIAVYKDQHKQLSVDHGVDNEDELKRLKDLGLDIEQikRNGRLGSHENTRSIGDYNIKI
.|.. .|      |.|| .|.|...     | ||||||| |.  . ..  .|| ||  ....| .|.|| |. . .   . |.     .|..||. || 
kevdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsd..nqtrinGlavsralGdhfike
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 152-220 1.2e-08 27.9 In-house 78-152 (292) alignment 
Range on Protein: 152-220
Range on HMM: 78-152/292.0
EIEPELAGGTTAVIAVVFNN-NLYVANVGDSRAIAVY-----KDQHKQLSVDHGVDNEDELKRLKDLGLDIEQIK
 |.  . ..|..| |.| .. .|..||||||||.        . . . || ||  .. || .|..  |  .|  .
tidaresattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptr
subfamily_ILKAP_pd Subfamily ILKAP 153-316 7.3e-15 47.9 In-house 107-254 (293) alignment 
Range on Protein: 153-316
Range on HMM: 107-254/293.0
IEPELAGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHKQ------LSVDHGVDNEDELKRLKDLGLDIeqikRNGR-LGSHENTRSIGDYNikigYKD
 .|    |.||.. .| .| |||||.|||.|. | |... .      |..||   ...| ||..  |  .    |.|| ||  | .||||| .    .| 
akPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvv....rdgrvlGvlevsrsiGdgr....fkr

VDVLSSatgpPGIAIPSINGpypiNDiEYILLMSDGVYKTLEyltdppTSDVYPRLLQLIQEAEKSVDLQD
. | |     | .    ..     ||  ...|  ||..|...      ...|    |......|.. ....
lGvist....PdvkkceLte....nd.lfvvlaCdGLwkvfs......adevvkfilkvledeeddrkike
subfamily_PPM1E_pd Subfamily PPM1E 156-240 2.9e-15 49.1 In-house 99-183 (265) alignment 
Range on Protein: 156-240
Range on HMM: 99-183/265.0
ELAGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHKQLSVDHGVDNEDELKRLKDLGLDIEQIKRNGRLGSHENTRSIGDYNIK
.| .|.|||.... ...|||| .|||.|. | | .  ||   |  ..||| ||....|  . .|      |.   .|.|||.. |
klksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk
subfamily_PPM1G_pd Subfamily PPM1G 157-286 5.2e-16 51.7 In-house 294-416 (473) alignment 
Range on Protein: 157-286
Range on HMM: 294-416/473.0
LAGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQHKQLSVDHGVDNEDELKRLKDLGLDIEqikRNGRL-GSHENTRSIGDYNikigYKDVDVLSSATGP
   |||||.|.. ...|.|||.||||..   . .  .||.||  ..| ||.|..  |  ..    .||. |     | .||..    ||    |      
edsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvd...edgRvnGGLnlsRAlGDha....YkkneeLplkeqm

pGIAIPSINGPYPINDIEYILLMSDGVYKTL
   |.| |.     .. |.. | .||.. ..
.isAlPDikvltlteedeFlvlAcDGiWnvm
subfamily_PDP_pd Subfamily PDP 158-251 1.5e-14 47.0 In-house 151-253 (398) alignment 
Range on Protein: 158-251
Range on HMM: 151-253/398.0
AGGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQH-----KQLSVDHGVDNEDELKRLKDLGLDIEQ--IKRNGR-LGSHENTRSIGDYNIKIGYK-DVDV
. |..|..|.. ...|.|||.||.||.   ....     ..|| |. .|||.|..|.|    . |.  . |||| ||.   .|  ||.. |.  . .  |
lsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkv

LSS
|..
lek
subfamily_PPM1D_pd Subfamily PPM1D 159-218 2.4e-09 29.7 In-house 108-173 (309) alignment 
Range on Protein: 159-218
Range on HMM: 108-173/309.0
GGTTAVIAVVFNNNLYVANVGDSRAIAVYKDQ------HKQLSVDHGVDNEDELKRLKDLGLDIEQ
 |||| . .. ...||||.||||...  .|..       |.| .||  .. .| .|...|| .. .
aGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 160-241 1e-08 27.4 In-house 105-194 (276) alignment 
Range on Protein: 160-241
Range on HMM: 105-194/276.0
GTTAVIAVVFNNN----------LYVANVGDSRAIAVYKDQHKQLSVDHGVDNEDELKRLKDLGLDIEQikRNGRLGSHENTRSIGDYNIKI
|.|| .|.|...           | ||||||| |.  . ..  .|| ||  .. .| .|.|| |. . .   . |.     .|..||. || 
GatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsd..nqtrinGlavsralGdhfike
subfamily_PP2D1_pd Subfamily PP2D1 170-237 1.6e-07 23.4 In-house 187-255 (492) alignment 
Range on Protein: 170-237
Range on HMM: 187-255/492.0
NNNLYVANVGDSRAIAVYKDQHKQLSVDHGVDNEDELKRLKDLGLDIEQIKRNGRL-GSHENTRSIGDY
   ||.||.|. .|. . . . ..|  .|   |. | .|..  |  . . ..||.  |  ..|| .| |
lgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny
SpoIIE Stage II sporulation protein E (SpoIIE) 273-362 1.2e-06 20.4 Pfam-A 125-192 (193) alignment 
Range on Protein: 273-362
Range on HMM: 125-192/193.0
EYILLMSDGVYKTLeyltdppTSDVYP----RLLQLIQEAeKSVDLQDIANKVLQDIKIshevvyydsamtdprstvavNC--RKRDDMTLIVLKF
. .||..|||. .        ..|       |||.|..|| .. .|............                     ..  ...||.||.||..
dllllyTDGvtEar.......dpdgelfgkerllallaea.egesleelldalveelle....................lgsgeleDDitllvlrv
SpoIIE Stage II sporulation protein E (SpoIIE) 273-362 1.2e-06 20.4 In-house 125-192 (193) alignment 
Range on Protein: 273-362
Range on HMM: 125-192/193.0
EYILLMSDGVYKTLeyltdppTSDVYP----RLLQLIQEAeKSVDLQDIANKVLQDIKIshevvyydsamtdprstvavNC--RKRDDMTLIVLKF
. .||..|||. .        ..|       |||.|..|| .. .|............                     ..  ...||.||.||..
dllllyTDGvtEar.......dpdgelfgkerllallaea.egesleelldalveelle....................lgsgeleDDitllvlrv
PPM_PTC7_SpoIIE_motif 274-362 7.8e-08 25.9 In-house 14-80 (81) alignment 
Range on Protein: 274-362
Range on HMM: 14-80/81.0
YILLMSDGVYktleyltDPPTSDVYP----RLLQLIQEAeKSVDLQDIANKVLQDIKIshevvyydsamtdprstvavNC--RKRDDMTLIVLKF
 .||..||..       . ..||       .||.|...| .. .||..| |......                     |.  ...||.||.||..
vllLyTDGlt.......Eardsdgelfgkeellrladra.egkslqeladklvdevle....................ngsgereDDitllvlrv