Gene C23G10.1 in Caenorhabditis elegans

Synonym: CELE_C23G10.1, CELE_C23G10.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP021_AA protein Get Run
CeleP021_AA_134-437 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
UCH Ubiquitin carboxyl-terminal hydrolase 31-134 2.4e-06 13.1 Pfam-A 4-88 (269) alignment 
Range on Protein: 31-134
Range on HMM: 4-88/269.0
LINDGTSCFLNIILQMLKR-ANFHDHFKGD----WQKGKQKMLMHKElqqifngkpgpkdvsrlremfsnealkdgphpLLVALKCLI--------KMSA
|.| | .|..| .||.|    .| . .. .    ... .... ...|                                |. ||. |.        . .|
leNlGntCYmnsvlQcLvnipefreylleekyeeeknessslgeege................................laraladlfekltsnksrkka

VSDNDVIKEKGARDKMF
|| . ..|  .. .|.|
vspkefkktlsklnkef
subfamily_PPP3C_pd Subfamily PPP3C 128-422 3.2e-67 220.3 In-house 14-310 (452) alignment 
Range on Protein: 128-422
Range on HMM: 14-310/452.0
GARDKMFQKQSDESNKMFAEHFIKTllackgmTKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDY
 . ...|....    ... |||.|         .. . .. ..|. . |..  .|...|.. |. ..||.|||. ||..||   .|| | ...|||||||
lteeevfdetgkpklevlkehflke.......grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfe..vgGdPastkylflGdy

VDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLR
||||.| .|..|  .| |  ||.....||||||  |. | . ||.|.  .   |  |.| .. | .|..|| ||. .. ||.||||| .||||||...| 
vdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckik...yseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkld

RPFHSEDECLENDIMWSDPAKVSGWTA--------NPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAG------KKLVTVFSAPHYMQSFT
|    .   .  |..||||..  | ..        ..|| |. .. . | |. .  |.  |.| |.. ..||. .          |.|.|||| |.....
rfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvyn

NSAAVCKVS
| ||| |. 
nkaavlkye
0045823 Metallo-dependent phosphatases 135-437 1.4e-95 313.7 In-house 19-326 (473) alignment 
Range on Protein: 135-437
Range on HMM: 19-326/473.0
QKQSDESNKMFAEHFIKTLLACKgmtKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFN
 . ... .... . .|..|. ..   ..   |...|.. .|.|.  .....|..... ..||.|||. ||.||....  ||||. ...||||.||||...
pllfillglldldlliehlkkeg...llpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrlleki..gfppedrlvflGDlvDrGpds

LEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRKGEYhdeLYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSED
|||..|.||.| .||.|. .||||||  ..|  |||.||.. . ||    ||.||.| .. .||.|..||.||..||||| ....||..|.. ||.. .|
levlelllalkikypgnvfllrGNHElrllnglygfgdetlekyged...lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipd

ECLENDIMWSDPAKVSG--------WTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKK------LVTVFSAPHYMQSFTNSAAVCK
..|  |..||||  ..|        .. .||||...||.. |.|..|  ..|||||||..|..|||.. ..|      ..||||||.|.  . | |||..
dgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlv

VSAGLeVSFEVLKPEDI
.. .| .|| ...| . 
idedl.isfiqfdpsph
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 140-437 2.6e-149 489.1 In-house 2-296 (298) alignment 
Range on Protein: 140-437
Range on HMM: 2-296/298.0
ESNKMFAEHFIKTLLACKGMTKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVIL
|......|.....| ..|....|...|...||...||||. |||.||.|.|...|||.||||.||.|||..  .|||||.||||||||||||..|||||.
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdk..agfppdanylflGdyvdrGrqnleviv

LCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRKGEYHdeLYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLEN
|.||||..|||||..||||||. .||..|||..|. .|. ...  || ||.......||.||.||||||||||||...||||.||.|.|||.|..|.|..
lllaykvkypnnffllrGnheceainrvyGfyeeckrrykslr..lyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslai

DIMWSDPAK-VSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPEDI
|..|.||.. |.||..| ||.||.|||..||.... |||||.||.||||||||||||.|||||.||||||...|.|||||.||.. |.|||||||||. 
dllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekk
subfamily_PPP5C_pd Subfamily PPP5C 140-430 1.3e-68 224.4 In-house 12-304 (322) alignment 
Range on Protein: 140-430
Range on HMM: 12-304/322.0
ESNKMfAEHFIKTLL-ACKGMTKIRTMDIFRLIHICKKIFTVQKSMVEIDGP----VRICGDLHGQYPDLIRLFaQVLGGFPPDSNYLFLGDYVDRGSFN
|..|. ...|.| ||   |   |...  .....   |...  . |.|||. .    . .|||.|||. ||. .| .. |   ..  ||| ||.|||||| 
eeeki.tkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnif.elnGlpseenpylfnGdfvdrGsfs

LEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVfnrKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLS-QHIKSLDDLRNLRRPFHSE
.||||. |..|  |||.| . ||||| ...|. |||..||   |  | ....  |.|. ...||  ..  ..| .||||  ..  .|||||.. |  .  
veviltllgfkllyPnhfflsrGnhesdnmnklyGfegev...kakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqpp

DECLENDIMWSDPAKVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKV-SAGLEVSFE
.| |  ...|||| . .| ..  || .|||| .  |...|  ...||.| |.| ..|||.    ||.|||||| | .. .| .|. .. .. |.. |.
eegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfk
subfamily_PPP2C_pd Subfamily PPP2C 147-434 2.7e-73 239.7 In-house 5-285 (290) alignment 
Range on Protein: 147-434
Range on HMM: 5-285/290.0
EHFIKTLLACKGMTkirTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKA
...|. |  || ..     .. .|..  |.|.. .. . |.  || .|||.|||. ||. ||   .||  ||.|||||||||||| . .| . |  | | 
dklieklkeckqle...esevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfk..iggkspdtnylflgdyvdrgyysvetvtllvalkv

RYPNNFMMLRGNHEVIHINEKYGFKDEVFNRKGEyhDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDP
||..   .||||||   | . ||| ||.. . |.   ...  | ...|..|| ||| ..|.|.||||| .|..||..|.| |     .|    |..||||
rykeritilrgnhesrqitqvygfydeclrkygn..anvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdp

AKVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKP
   .||.  ||||  .||..  ... |  .. ||.| ||.| .||..   ...||.|||| |     | ||. ..   |. ||   .|
ddrggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
subfamily_PPP6C_pd Subfamily PPP6C 148-426 5.5e-70 228.8 In-house 4-275 (290) alignment 
Range on Protein: 148-426
Range on HMM: 4-275/290.0
HFIKTLLACKGMTKirtMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKAR
..|..   || ...    |. .| .. ....  . ... .  || .|||.|||. ||  || .  ||  ||..|.||||.|||| . || . . |. ||.
kwielakkckylpe...ndlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrt..ggqvpdtsyvflgdfvdrgyysletftrlltlkak

YPNNFMMLRGNHEVIHINEKYGFKDEVFNRKGEYHDELYpeFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA
||.. ..||||||  .| . ||| || .|. |.     |  . ...|.... |.. ...||.||||| ..| ||..| . |  .   .    |..|||| 
ypdritllrgnhesrqitqvygfydeclnkygnanawky..ctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe

KVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLE
.|. |.  ||||   ||.. .||.... ...||.| ||.|..|....  .|||||.||| |     | |.. ...   |
dvetwavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaee
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 153-437 4.8e-166 543.8 In-house 2-279 (280) alignment 
Range on Protein: 153-437
Range on HMM: 2-279/280.0
LLACkgmtkIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNF
||||     |...||.|.|..||||.|.|..|||.|.||..||||||||.||.||||.|  .||||.||||||||||||...||||||.||||.||||||
llac.....ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarv..sfppdqnylflgdyvdrgrqqlevillllaykvrypnnf

MMLRGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSG
..||||||||.||.||||||||..|   |...||.||.|..|..||||||.||||||||||||...|||||..|||||.||||||..|..|.||. ||.|
lilrgnhevisinrkygfkdevkrr...yslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtg

WTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE--DI
|..|.||.||.||.|.||.....||||||.||||||||||||||.||||||||||.|...|.|||||..|...|.||||||||.  ..
waensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalrev
subfamily_PPP4C_pd Subfamily PPP4C 158-433 3.6e-77 252.4 In-house 12-283 (288) alignment 
Range on Protein: 158-433
Range on HMM: 12-283/288.0
GMTKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRG
 .  |.  .. .| .  ..|.  .  . ..| || .|||.|||. ||..||   .||  |. |||||||.|||| . .| .|| ||.|.|||.. ...||
rcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfk..vggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirg

NHEVIHINEKYGFKDEVFNRKGEYHdeLYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPAKVSGWTANPR
|||  .| . ||| ||. .. |. .  ..    |..|...| |.. |.|.|.||||| .|..||..| . |     .|    |..|||| ...||.. ||
nhesrqitqvygfydeclrkygsan..vwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaegwavspr

GASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLK
||   ||...|.....  ||.||.| ||.|..|| .   .|..||.||| |     | ||. .. . |.  |....
gagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkife
subfamily_PPP1C_pd Subfamily PPP1C 160-436 1.1e-103 339.3 In-house 8-280 (282) alignment 
Range on Protein: 160-436
Range on HMM: 8-280/282.0
TKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNH
.|... .| .|..  ..|.. |  ..|.. ||.|.||.|||| ||.||| .  .|.||.|||||||||||||.. ||.|.| |||| .||.|. .|||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfet..sgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnh

EVIHINEKYGFKDEVfnrKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPAK-VSGWTANPRG
|  .||. |||.||.   |  |. .|.  |... ...|| |||  .|||.|||||...|||...|...|| . ... |  |..|||| | | ||..| ||
esasinriyGfydec...krrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

ASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPED
 |..||.. |.....  |.|||||.||||.||||||| ..||||||||.|. .| |..|| .|.. | |||..|||..
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
0053225 Metallo-dependent phosphatases 160-433 2.3e-85 279.5 In-house 20-289 (293) alignment 
Range on Protein: 160-433
Range on HMM: 20-289/293.0
TKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNH
 ..   ....|.. .|.|.  .....|..... ..||.||.. ||..|....  ||||.....||||.||||...|||..|.||.|..||.|. .|||||
kllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlalleki..gfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNH

EVIHINEKYGFKDEVFNRKGeyHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPAKVSGWTANPRGA
|  ..|  |||.||.. . |  ..||..|... .. .||.||.||.||..||||| .. .||..|.. ||.....| | .|..||||  .|||. ..||.
Elmllnglygfgdetlrkyg..aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsgwlpsyrgl

SVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLK
.| ||.. |....|. ..|||.||||||.|||... ..|||||||||.|.  ..| .|| ... || ..| ...
gvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 161-436 1.2e-101 332.9 In-house 23-295 (299) alignment 
Range on Protein: 161-436
Range on HMM: 23-295/299.0
KIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHE
 ..  .. .| ...|..|. | |..|.. |...|||.|||| ||.|.| .   |||||.|.||||||||||  |||.| | |..| .||..|.|||||||
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdk..agfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhe

VIHINEKYGFKDEVFNRKGeyHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGA
.  ||  ||| .|. .|       |.  |.. ...|||. |.|.|||||||||| ....|| ||.| ||    .  |. |..|.||   | .| || || 
cpainrvygfyeecnkryk..strlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgv

SVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPED
|  ||.. |..... |||||. | |||||||||||| |||||.||||||   | ||||. ||   | ..| |||| .
syvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp
0049330 Metallo-dependent phosphatases 161-437 4.3e-89 291.6 In-house 29-301 (309) alignment 
Range on Protein: 161-437
Range on HMM: 29-301/309.0
KIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHE
..   ....|....|.|.  .....|..... ..||.|||. ||.||....  ||||. ...||||.||||...|||.|| ||.| .||.|. .||||||
llseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrlleki..gfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHE

VIHINEKYGFKDEVFNRKGeyhDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGA
  ..|  |||.||.. . |   .||..||..... .||.|..||.|||.||||| ....||..|.| ||... .. | .|..||||   ..|.. ||||.
lrllnglygfgdetlrkyg...aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprgl

SVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPEDI
.| ||.. |.. .|....|||.|||..|..||..|...||.||||||.|.  . | .||.... .|..|| ...| ..
gvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 161-435 7.5e-77 251.2 In-house 15-289 (290) alignment 
Range on Protein: 161-435
Range on HMM: 15-289/290.0
KIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHE
 .   ||. ...  ..|.    ...|.  |. | ||.|||  .|.| | .|  |.||. ..||||||||||.  ||| || . || ||...  .||||||
afsdkdileilekieeileplpalleveapivivgdihgqldallryfdav..gyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

VIHINEKYGFKDEVFNRKGeyhDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHS--EDECLENDIMWSDPAK--VSGWTAN-
| ..|  ||||.|.  ..|    .|.  ...... ..| | || .|||||||.||.|.| . |. |..|      || |  |..|.||..      . | 
vrkvnrlygfkeelarkrg...srlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnk

PRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE
 |. || ||.. . ...| | ..|||| |.| ..|..|   ||||||||||.|    ||  |. .||  ||.|. ||||.
qraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 161-216 1.5e-08 27.2 In-house 8-61 (317) alignment 
Range on Protein: 161-216
Range on HMM: 8-61/317.0
KIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFP
 ... ..  | .  ...|  .. ..|.. || |.||.|||. ||. |.   | |.|
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalld..lnGwp
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 162-435 3.1e-84 275.8 In-house 8-283 (284) alignment 
Range on Protein: 162-435
Range on HMM: 8-283/284.0
IRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFP------PDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMML
..  ....| . ....|  .|  .||. ||.|.||.|||. ||. |.   | |.|       ...||||||||||| | .|||.| .||| ..|.. ..|
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalld..lngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDP-AKVSGWTA
|||||   .| .|||  |  .|   | . ||  |.  .  |||.|.|. .|.|||||.|... .|..| .|.||.   |  .  |. |.|| |.|.|.. 
rgnhesrpvnmqygfyleckkr...ysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyke

NPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE
 ||||   ||.. |||..|  ..||.|| ||||.||||||| .||||.|||| |   . | ||| .|.  |..|| ||||.
sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkpd
subfamily_PPZ_pd Subfamily PPZ 163-436 1.1e-80 264.4 In-house 26-295 (300) alignment 
Range on Protein: 163-436
Range on HMM: 26-295/300.0
RTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVI
.  .|... . ....|  | ...|.  .|.| ||.|||| ||.|||...  |||| .||||||||||||  .|| ||| |.|| .||.||..||||||. 
knseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkc..gfppsanylflgdyvdrgkqsletillllcykikypenffllrgnheca

HINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPAKVS-GWTANPRGASV
 .   ||| ||.  |      ...  | . .. .|| |.| |.|.|.|||||  ..|.|..| . ||    |  | ||..||||.  |  |  | || | 
nvtrvygfydeckrr...cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsy

QFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPED
 . .  .... . . .||..| | ||.||||||  . |||||||| |   | |  ||  || || .|||.| | |
cynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpld
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 163-434 4.6e-74 242.3 In-house 7-299 (302) alignment 
Range on Protein: 163-434
Range on HMM: 7-299/302.0
RTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQV----------LGGFPpDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNF
   ... ||.   . . ..|...||  || | ||.|||..||.|....             .|   . ..||||||||||  .| | | .|.|  ||.|.
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptny

MMLRGNHEVIHINEKYGFKDEVFNRKGEYH-DELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSE-DECLENDIMWSDPAKVS
..||||||.  ||  |||..|. || |. .  |.. .|||..  ||| |||| .|||.|||.|....||.|.....||..   .. | .|....||. | 
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWTA----------NPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKP
. .|          . || || | |  |...|| |...||||.||..  |. ||| |||.|.|||| ||    |. || || .  ..|  ||..
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 163-434 8.2e-74 241.5 In-house 8-300 (302) alignment 
Range on Protein: 163-434
Range on HMM: 8-300/302.0
RTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQV----------LGGFPpDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNF
   ... ||.   . . ..|...||  || | ||.|||..||.|....             .|   . ..||||||||||  .| | | .|.|  ||.|.
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptny

MMLRGNHEVIHINEKYGFKDEVFNRKGEYH-DELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSE-DECLENDIMWSDPAKVS
..||||||.  ||  |||..|. || |. .  |.. .|||..  ||| |||| .|||.|||.|....||.|.....||..   .. | .|....||. | 
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWTA----------NPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKP
. .|          . || || | |  |...|| |...||||.||..  |. ||| |||.|.|||| ||    |. || || .  ..|  ||..
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
PP2Ac_SM00156 164-435 2e-108 354.5 In-house 3-270 (271) alignment 
Range on Protein: 164-435
Range on HMM: 3-270/271.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFaqVLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
. ....|.. .|.|.. .|..||...|| ..||.|||. ||.||.   |.|.||...|.|||||||||....|||||..|.| .||.....||||||  .
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll..elageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsss

INEKYGFKDEVFNRKgeyHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDP-AKVSGWTANPRGASVQ
.|. |||..|| ...   ..|.| .|.|.....|| |||. .|||||||||....||||.|.|.|. ....|.|  |..||||  |..|.... ||.||.
vnkiygfeeevkrky...gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvv

FGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE
|||. |||..| ....||.|.|.||..|||||| |||||.||||.|...|.|.|||.||. .|. |.|.||..
FgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
PPP_3 164-433 1.1e-94 309.5 In-house 4-270 (271) alignment 
Range on Protein: 164-433
Range on HMM: 4-270/271.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
. .. .|.. .|.|.. ....|||. || .|||.|||. ||..||    ||..|...|||||||||||.. |||.|| ||.| .||.....||||||  .
enelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfk..nggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INEKYGFKDEVFnrKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDI-MWSDPAKVSGWTANPRGASVQ
||. ||||.||.  | ......| ...|.....|| ||. ...|..|||||..|||||....|.|. ....|..  |  ..|||.| .|.. ..|||.. 
inkvYgFkkevl..kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagll

FGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLK
||.. ..|...  ...||.| |.....|||... .|.|||||||.|.....| .|..|... |. .|..|.
FgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 164-438 2.2e-92 302.0 In-house 12-285 (287) alignment 
Range on Protein: 164-438
Range on HMM: 12-285/287.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
  ||. ...  ..|.   ....|.. |. |.||.|||. ||.|.| .|  | .|. .|||||||||||.  |||.|| ...| .||..  .||||||| .
dkdilevlekieeileplpalleveapitivGdihGqlddllrifnav..GaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

INEKYGFKDEVFNRKGeyhDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSE--DECLENDIMWSDPAKV-SGWTAN-PRGA
||..||||.|. ....   ..|| .||.... .|| | |. ||||||||.|...||||.|. |..| .    || |  |..|.|| |   .   |  |. 
inklyGfkeelkrkrq...erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

SVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPEDIR
|| ||..|| ...| |||||||| |.|...||.|.. |.||||||||.|.   || .|| .||  ||.|| |||||| .
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedfe
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 164-434 8.6e-90 294.0 In-house 25-294 (297) alignment 
Range on Protein: 164-434
Range on HMM: 25-294/297.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
   ...|. .. ..|  ||||||.. |...|||.|||.|||.||| .  ||.|| .|||||||||||| | .| |.| |||| ..| |...||||||.  
eervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhr..ggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

INEKYGFKDEVFNRKGEyhDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQ---HIKSLDDLRNLRRPfHSEDECLENDIMWSDPA-KVSGWTANPRGA
.|. ||| .|. .|       .|  |..... .||. |.  .|||||||||    .  .|| ||.. |. .   | |  |..|.||   .||.  | |||
vnkvygfyeecqkryqs..vrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiers.tegkerlvadllwadpisglsgfmenqrga

SVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKP
 . || . | ..|  ...||..| |||||||||||||.||||.||||||   | | ||.  .   |..|||.|.|
gcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 164-436 1.3e-84 276.7 In-house 10-278 (281) alignment 
Range on Protein: 164-436
Range on HMM: 10-278/281.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
  .|  .|.  . ||. .|..|||| |. . ||||.|. ||.|||   | | .|.  ..|||||||||  .|||..| ...| ||... ..||||||. .
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfe..llgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

INEKYGFKDEVFNrkgEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGASVQ
.| .|||  |       |  ||. .|.. .. .|. ||.  |.||||||||  . .||.|||  .| .. |  | .|..|.||  || .| |  ||.|  
vnkiygfyvecvt...kyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPED
||.| |...|| |...||.|.||||||||| ..|.||.||||.| | . ..|.||| || . |..|.  | |. 
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 164-435 1.7e-73 240.5 In-house 8-275 (280) alignment 
Range on Protein: 164-435
Range on HMM: 8-275/280.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqVLgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
  .|  .|.. . ||  .  ..| . |... ||.| || |. |||  .. |  |. . .|||||||||   .||..| .. | || .   .||||||   
gheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfd.li.grvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetps

INEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGASVQ
.|. |||  |.  .   |   |. .|.  .. ||. .|.  |.||||||||  .  || .||. ||    |  |  |..||||. |  ||  . || |  
vnkiygfyvecqyk...ygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisym

FGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE
||.  |.. || |.||||.|.|||||||||..||..|.|||| | |   |||.|||  . | |.|||. | | 
fgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 166-435 5.8e-89 291.3 In-house 7-274 (284) alignment 
Range on Protein: 166-435
Range on HMM: 7-274/284.0
DIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHIN
|.  |.  . .||  |  ..|.. |. ||||.|||. ||.||| .   |||  .||||||||||||   || ||| .|||  .|| |.|||||||.  ||
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdk..ngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

EKYGFKDEVFNRKGeyHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFH-SEDECLENDIMWSDPAKV-SGWTANPRGASVQF
..||| .|.  |    .  .|  |. ..  ||| |||| ||||||||.|. .. . .|| ..|||   | . |  ||.||||...  ||  | || |  |
kiygfyeecqrryn..kpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE
| . ....   |.|||.|| |||||||||||| ..|||.|||| |   | |.|||  |   | .|| ||.| 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrpr
PPP_1 166-421 3.5e-82 268.6 In-house 5-264 (264) alignment 
Range on Protein: 166-421
Range on HMM: 5-264/264.0
DIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHIN
 ...|..  |.... .. ..|.. .. .|||.|||. ||..|| .  ||..|..||||||||||||.. .|..|| ||.| .||.....||||||  ...
elaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkv..ggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

EKYGFKDEVFnrKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDI--------MWSDPAKVSGWTANPR
. ||||.||   | .|  |.|  . .. |..|| ||. ..||..|||||.....||. |..||  .. .|.  .|         ...|... .... ..|
kvygFkkEvl..kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiR

GASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKV
||. .||.. ......  ...||.| |.|...||||.. .|.||.|||. |.....| .|..|.
GagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 168-442 2.6e-72 236.6 In-house 26-299 (307) alignment 
Range on Protein: 168-442
Range on HMM: 26-299/307.0
FRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFaqVLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEK
  .|. .. ||. .|..|.|| |. . ||||||. ||| .|  .| | ||.. |.| ||||||| ..||.||| ..||  ||.| ..||||||. ..|.|
enviyeaqtifssekalvdidppcvvvgdlhgqfndlinmf..illgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkk

YGFKDEVFNRKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGASVQFGEN
||| .|.        .|..  |.  .. .|. ||.  .|||||||||  .  ||.|||  .|       . ||..|.||   |  | |  ||. . || |
ygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtn

EVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPEDIRVEEI
 . ..|| | ..||.| ||.. |||  ..|.||.|.|||| | . . |. .| ||   | .    . ||   .|.|
viddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesenieki
subfamily_PPP7C_pd Subfamily PPP7C 168-328 4.1e-32 104.4 In-house 39-201 (383) alignment 
Range on Protein: 168-328
Range on HMM: 39-201/383.0
FRLIHICKKIFTVQKSM----VEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPP-DSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVI
  ... .||..   ...      |   | .||||||.  ||. .. .   |.|  . .|.| ||.||||.  .|..|. ||.   ||... . |||||  
llilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyk..nGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedh

HINEKYGFKDEVFNRKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHiKSLDDLRNLRR
 .| .|||  || ..  ... ..   ....   .|| .|.  .|| .|||.|..  .|. | .. |
ilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkier
subfamily_PPG1_pd Subfamily PPG1 170-432 2.6e-57 187.3 In-house 22-293 (300) alignment 
Range on Protein: 170-432
Range on HMM: 22-293/300.0
LIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYG
|..  |...  .  ..||  || . ||.|||. |.. .|   .||  ||.|||||||||||| . .| | | .. | |||    .||||||   | . ||
ltdklkellvkesnvieirspvtvvgdvhgqfydvleifk..iggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvyg

FKDEVFNRKGEyHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA----------KVSG--WTANPR
|  |.... |     ..  . |..| . |.|..   | |.|||||  ..|.|... | |     .|    |..||||             .|  ..  .|
fyteclrkygg.nsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqr

GASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVL
||   .|.. |... .  |.. |.| ||....||. .  .|| ||.||| | .   | |.. ..   .|  |.| 
gagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
subfamily_PPPLV_pd Subfamily PPPLV 173-422 2e-47 154.9 In-house 8-276 (290) alignment 
Range on Protein: 173-422
Range on HMM: 8-276/290.0
ICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIrLFAQVLGG---FPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYG
.  .|.  .. ..|.. |. . |||||.| |||  |..||         ...|||||||||| |..|.|   || |  ||  ...||||||.  . |.. 
vavdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesie

FKDEVFNRKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDD---LRNLRR--PFHSEDECLENDIMWSDPAK------------VSGW
.| | . . |.  .| .  ||...|..|| | .  ...|.|.|. . |..      ....    . . .   |  ||.|||||.              |.
ykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGf

TANP-RGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSfTNSAAVCKVS
  |  || .  |.|. .. . |  ... ..| |.| . |...  . .|.||||. .|  | .|.||.  |.
vdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 184-439 1.6e-76 250.4 In-house 2-260 (263) alignment 
Range on Protein: 184-439
Range on HMM: 2-260/263.0
MVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNR--KGEY
..|.. |. |||| |||| ||.|.|  .  |    ..||||||||||| ..||||.| .. |   | .. .||||||.  ||..|||. |. .|  . | 
llelqapinicgdthgqyndllrifnac..gaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreev

HDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHS-EDECLENDIMWSDPAKV-SGWTANP-RGASVQFGENEVKEMCKLLDID
.. .|  ||...  |||.|.|  ||||||||.| |.|||||.| .  |. . .   |  |..|.|| |   |.  |  |  |  ||..|| ..|| ||||
yesvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldid

LIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPEDIRV
|||| ||||. || ||| ..|.||||| .|   . | |||  |   ||.||  |||||. |
livrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfev
Metallophos Calcineurin-like phosphoesterase 190-387 1.4e-39 129.5 Pfam-A 2-199 (200) alignment 
Range on Protein: 190-387
Range on HMM: 2-199/200.0
PVRICGDLHGQYPDL--IRLFAQVLGGFPPDSNYLFLGDYVDRGSFNLEVILLC--LAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFN---------
.. ..|||||.. ||  ..|  . ... ..  ..|||||.||||   .|.. |   |..| ..|.....||||||. ..|. |||..|...         
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

----------------------RKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLrnlrrpfhsedeclendimwsdpakvsgwta
                       .... |. . |..|  . .|| |||.|.||..||.|| . .| ||                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

nprgASVQFGENEVKEMCKLLDIDLIVRGHQVV
    .|. ||.... . ..  ..||..|||. .
....gselfgpdalekllekygvdlvlrGHtHk
PPP_2 191-386 3.5e-67 218.9 In-house 1-197 (198) alignment 
Range on Protein: 191-386
Range on HMM: 1-197/198.0
VRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFnrKGEYHDELYPEFN
|..|||||||. ||..||    |...|...|||||||||||...|||.||.||.| .||.....||||||  ..|. ||||.||.  | ......| ...
vtvcGDlHGqldDLlilfk..nglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl..kkkggkkvykklq

EMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDI-----MWSDPAKVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQ
|.....|| ||. ...|..|||||..||.||. .. .|. .|..|.. .|      ......| .... . |||.. ||.. ..|...  ...||.| |.
evfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHe

V
|
v
PPP_4 191-386 9.5e-66 214.6 In-house 1-196 (197) alignment 
Range on Protein: 191-386
Range on HMM: 1-196/197.0
VRICGDLHGQYPDLIRLFAQvLGGFPP-DSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEF
| ..||.|||. ||.  . . .||.|. ...|.|||||||||...|||.|| ||.| .||.....||||||  ..|. ||||.|| ..   ...|.. ..
vtvvGDiHGqlddlllkllk.ngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek...hgkeilkkl

NEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSE-DECLENDI-MWSDPA-KVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQV
....|..|| ||. ...|..|||||....|||......|...|. .|.. .|. .||||. . .|.. . |||.. ||.. ......  ...||.|.|..
qdvfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 191-387 5.4e-64 208.8 In-house 1-199 (199) alignment 
Range on Protein: 191-387
Range on HMM: 1-199/199.0
VRICGDLHGQYPDLIRLFAQVLgGFPP-DSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRKgeYHDELYPEF
| .|||||||. ||.  . .   |.|. . .|.|||||||||...|||.|| ||.| .||.....||||||  ..|| |||..|| ..   .. ..|  .
vtvcGDlHGqlddlllilfkeg.gdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky..hgkkiykil

NEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSE-DECLENDI-MWSDPA-KVSG-WTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQ
....|..|| ||. ...|..|||||..|||...|....|..... ..  ..|. .||||. ...| .. . |||.. ||.. ......  ...||.|.|.
sdvfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshe

VV
..
lk
subfamily_YNL217W_pd Subfamily YNL217W 193-266 4.9e-08 25.8 In-house 14-81 (235) alignment 
Range on Protein: 193-266
Range on HMM: 14-81/235.0
ICGDLHGQYPDLIRLFAQVLGGFPPDSNYLFLGDYVDRGSFNLEVILLClaykarYPNNFMMLRGNHEVIHINE
. || || | .||.|. .  ||  ..   ...|| ...|  ..||. .         ..   ..|||| . . .
vvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 193-385 8.1e-07 21.2 Pfam-A 5-118 (156) alignment 
Range on Protein: 193-385
Range on HMM: 5-118/156.0
ICGDLHGQYPDLIRLFAQVlGGfppDSNYLFLGDYVDRgsfnLEVILLClaykARYpnNFMMLRGNHEVIHINEKYGFKDevfnrkgeyhdeLYPEFNEM
| .||||.  .| .. ...  .      .|..||.|..     ||. |     ...  .. ..||||.  ...... ..             |...... 
iiSDlHgnldaleavledi.ke...vdlilhaGDlvep....eevvell....edi..pvlavrGnhDeaelpkelavel............llaaaale

MDmmplvalvGGRILCMHGGLSQhikslddlrnlrrpfhsedeclendimwsdpakvsgwtanprgasVQFGENEVKEMCKLLDIDLIVRGHQ
..        | |.| .||   .                                             ||..|.|..| .|  . ||.. || 
ie........gdrvllvhgtpls.............................................vqsseeelaellkeagadlvflGHt
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 219-435 3.5e-78 256.0 In-house 101-315 (317) alignment 
Range on Protein: 219-435
Range on HMM: 101-315/317.0
SNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIK
..||||||||||| | .||..| .|.| .||.. ..||||||   .| .|||  || .|   |  .||  |. .. ..||.|.|. .|||||||.|... 
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkr...ysaalyeafqlafnvlplcavvnkkilcmhGGiseell

SLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAA
.|. | .|.||..  |  .  |. |.||  .|.|.   .|||.  ||.. |||..| ||.||.||.||||.|||||||..||||.|||| |   . | ||
dlkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaa

VCKVSAGLEVSFEVLKPE
| .|   |..|..||.||
vlsvdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 220-436 1.6e-61 201.3 In-house 121-335 (339) alignment 
Range on Protein: 220-436
Range on HMM: 121-335/339.0
NYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKS
 ||||||||||| | .||..|  | |  ||.   .||||||   .|  |||  ||  |   |  .||  |..|....|..|..   |.|||||.|.|. |
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyr...ydaqlyecfqnmfnvfpfcavinntimcmhggisehlts

LDDLRNLRRPFHSEDECLENDIMWSDPAKV-SGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAV
....  ..||.   |  .  |. |.||     |.    ||||. ||   .. . | ||.....||||||.|||||| |..|||.|||| |     |.|||
fnqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaav

CKVSAGLEVSFEVLKPED
  .   |..| .|..|| 
fsidkklkisinvfrpes
subfamily_PPP7C_pd Subfamily PPP7C 340-425 5.9e-17 54.4 In-house 239-325 (383) alignment 
Range on Protein: 340-425
Range on HMM: 239-325/383.0
DIMWSDPAKVSGWTANP-RGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGL
||.|||| . .| ..|  ||. . || .  |.. .  ...|..| |.  ..||||   ||..|.|||  | .  .|  |  |..  |
dilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdl