Gene C25A6.1 in Caenorhabditis elegans

Synonym: CELE_C25A6.1, C25A6.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP026_AA protein Get Run
CeleP026_AA_4-284 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 5-285 4.7e-196 642.8 In-house 1-297 (297) alignment 
Range on Protein: 5-285
Range on HMM: 1-297/297.0
VVDNIIIDVLSASTHEKLLSEVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLL
|||.||||||||||||||||.||||.||||||||||||||.||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
vvdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivll

LAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQKRYQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSP----------------SHDGKERLVADL
||||||||||||||||||||||||||||||||||||||||||..|||||||||||.||||.|||||||||||                |..|||||||||
laykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegkerlvadl

LWADPISGLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTSG
|||||||||||||||.||||||||||||||.||.|||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrptsg
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 5-284 1.3e-147 483.6 In-house 2-295 (298) alignment 
Range on Protein: 5-284
Range on HMM: 2-295/298.0
VVDNIIIDVLSASTHEKLLSEVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLL
.||...|.|||.|..|| |..||.| .| ||..|| ..||.|||.||..||||||||||||..||||||...|.||.||||||||||||||...|.||||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQKRYQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSP-------------SHDGKE-RLVADLLW
||||||.| |.||||||||||..|.||||||||..||.|.|....||||||.|||..||...|||||||||.             ..|.|| .|..||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

ADPISGLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTS
||| . ..|..||.||... ||.|.| ........||..||||||||||||||..|||||||||||||||||.||.|..||||..|||.|.|..
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
0049330 Metallo-dependent phosphatases 5-284 2.2e-94 309.0 In-house 8-300 (309) alignment 
Range on Protein: 5-284
Range on HMM: 8-300/309.0
VVDNIIIDVLSASTHEKLLSEVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLL
.....|...|.. ..  |   ...|  .|.||. | ...| .....|....| |.||||||. |||||... |.||  ...||||.|||| .|.|.. ||
lllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevllll

LAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQKRYQsVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDGKERLVA--------------DLLW
||.|...|.| ||||||||. ..| .|||..|.. .|  .... .|.|....|||. .| .||||.||||||..   . . .              ||||
lalkllypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllw

ADPISGLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTS
.||.   .|| .| ||.|. || .|| ...  ..||||.|.|..|..||..|...||.|.||||.|||...|..|..  ||.| .|| ...|..
sdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvp
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 6-285 7.8e-116 379.5 In-house 3-296 (299) alignment 
Range on Protein: 6-285
Range on HMM: 3-296/299.0
VDNIIIDVLSASTHEKLLSEVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLL
||...  .|.    || |.. . |  . .| ..| .||  | |..|..|||.||||||||. ||||.|.. |.|| .|.|||||||||||  .|.|.|||
vdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlll

AYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQKRYQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDGKE--------------RLVADLLWA
..|.|.| ..|.|||||||  .|.||||||||.|||.| |....||| |...||.|||...||||||||||  .  .               |  |||||
cfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwa

DPISGLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTSG
||   . ... | ||    ||.| | .|.| ...||..|||||||||||||| .||||||||||||||||| || |  ||.| |.| .|.||. 
dpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpk
subfamily_PPZ_pd Subfamily PPZ 6-283 5.4e-90 294.9 In-house 3-294 (300) alignment 
Range on Protein: 6-283
Range on HMM: 3-294/300.0
VDNIIIDVLSASTHEKLLSEVI-TEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLL
.|.||  .| |    |   .|   .  .|..   | ..|  | ...|.. ..|. ||.|||. |||||| . |.||.|||||||||||||. |.|||.||
ideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletilll

LAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQKRYqSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDGKE--------------RLVADLLW
|.||.|.| |.|||||||||  | .|||||.||..|   .... .| | || |||. ..| ||.|.||||||  .  .               |. ||||
lcykikypenffllrgnhecanvtrvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllw

ADPISGLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
.||      . .|.||    . . |. |.   | .||.|||| ||.||||||  | |||.|||| |||.|||  | ||  | | ||||.| | 
sdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpl
0045823 Metallo-dependent phosphatases 9-284 1.1e-98 323.9 In-house 25-325 (473) alignment 
Range on Protein: 9-284
Range on HMM: 25-325/473.0
IIIDVLSASTHEKLLSEVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYK
. . .|.. ..  .  ....|  .||||| | ...|......|....| |.||||||. |||||... |.||  ...||||.|||| .|.|.. ||||.|
lglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalk

VKFPGNLFLLRGNHECEFVNKVYGFYEECQKRYqSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDGKERLVA--------------DLLWADPi
.|.||| ||||||||. ..| .|||..|. ..| ..... .|......|||. .| .|||..||||||...  . ...              ||||.|| 
ikypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.

SGLSG--------FMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRK------LVTIFSAPHYCGQFDNCAAFMSCDEKLqCSFEIL
   .|        |. . ||||. ||.||| .......||||.|.|..|..|||.. ..|      ..|.||||.|||...|.||..  ||.| .|| ..
weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqf

RPTS
.|..
dpsp
0053225 Metallo-dependent phosphatases 10-282 1.9e-87 286.3 In-house 5-290 (293) alignment 
Range on Protein: 10-282
Range on HMM: 5-290/293.0
IIDVLSASTHEKLLSEVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKV
|. .|.. ..  ||  ...|  .|.||..| ...|......|....| |.|||||.. |||.|... |.||. ...||||.|||| .|.|.. ||||.|.
illlldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkl

KFPGNLFLLRGNHECEFVNKVYGFYEECQKRYQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDGKE--------------RLVADLLWADPIs
..|.| .|||||||. ..| .|||..|.  .| . ... ...|....|||. || .|||..||||||...  .              .|..|||| ||  
lypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.

GLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRP
  ||.. . ||.|. || .|||...  ..||||.|.||||.|||... ..||||.||||.|.|...|..|..  ||.| ..| ...|
lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_PPP4C_pd Subfamily PPP4C 24-281 2.6e-79 259.4 In-house 13-283 (288) alignment 
Range on Protein: 24-281
Range on HMM: 13-283/288.0
SEVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHE
.|.|.|  | .|   | ...  .  . ....|. ||||||||| |||.||. ||  |  |||||||.|||| .|.||..||||.||..| .. |.|||||
celikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhe

CEFVNKVYGFYEECQKRYQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDG--------------KERLVADLLWADPISGlSGFMENNRGAGC
.  . .|||||.|| ..| |....    .||..|.|. .| .||.|.||||||| .               .|  ..||||.||    .|.    |||| 
srqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpeda.egwavsprgagy

GFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILR
 || |.| . ... ...|||||||.|..|| .   .|..|..||| || .  | || .  ||.|.  |.|. 
lfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkife
subfamily_PPG1_pd Subfamily PPG1 24-280 1.7e-65 214.3 In-house 11-293 (300) alignment 
Range on Protein: 24-280
Range on HMM: 11-293/300.0
SEVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHE
.|.. |  | .| |   ... ..  ..|...|. | ||.|||| |.| .|. ||  | .|||||||||||| .|.|||.||.. |...|  . |||||||
aellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhe

CEFVNKVYGFYEECQKRY-QSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDG--------------KERLVADLLWADPI---------SGLSG
   . .||||| || ..|    |..  . ..|..| |. .| ..| |.|||||||                 .|  .|||||.||             .|
srqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdreg

--FMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEIL
  |.. .||||  .|.| |.|     ... | ||||....||. .   || |..||| || .  | |. .   ||..  |.. 
qhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 25-283 2.1e-104 341.6 In-house 4-275 (280) alignment 
Range on Protein: 25-283
Range on HMM: 4-275/280.0
EVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHEC
..| |  . ....   .... |..|||..||..||||.|||..|||||| | ..||  |||||||||||||. .| |.|||||||..| |...||||||.
acikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhev

EFVNKVYGFYEECQKRYqSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSP--------------SHDGKERLVADLLWADPISGLSGFMENNRGAGCG
  .|. |||..|...|| |  ... ||.... |||. |.. .|||||||||.               .  .| |  ||||||| . ..|. ||.||.   
isinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvi

FGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
|| . | ...  ...|||.| ||||||||||||..||||.||||.|.|.||| || .  ||.|. |||.|.| 
fganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 25-284 3.1e-83 272.0 In-house 8-283 (287) alignment 
Range on Protein: 25-284
Range on HMM: 8-283/287.0
EVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHEC
. ...  .|..|. . ....  ....|..|||...||||||. ||||.|.  | .|  .|||||||||||  |.| ..||...|...| .. |||||||.
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

EFVNKVYGFYEECQKRYQsVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDG----------------KERLVADLLWADPISGLSGFMEN-NRGA
. .||.|||.|| ....|  |..  |.|||. ||||  ....|||||||.||  .                 .| |. |||||||     .|  |  |. 
kkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

GCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTS
   ||.  | ...  ...||| |||.|...||.|.. ..|||.||||.|.|.  |..| .  .. |. ||  |.|  
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkped
subfamily_PPP2C_pd Subfamily PPP2C 25-283 3.1e-79 259.2 In-house 15-286 (290) alignment 
Range on Protein: 25-283
Range on HMM: 15-286/290.0
EVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHEC
. ..| .| .| . | ....... . |...|. ||||.|||| ||| ||. ||  | .|||||||||||| .|.||. || | ||...  . .|||||| 
kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhes

EFVNKVYGFYEECQKRYQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDG--------------KERLVADLLWADPIsGLSGFMENNRGAGCG
  . .|||||.|| ..| .  ... | |.|..|||..|. ..|.|.||||||| |               .|  ..||||.||    .|.   .||||  
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagyt

FGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
||.|   |     .| || ||||.| .||..   |..||||||| || .  | || .  |.||. ||    |.
fgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 25-282 8.5e-73 238.2 In-house 4-274 (280) alignment 
Range on Protein: 25-282
Range on HMM: 4-274/280.0
EVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHEC
.|.|   .. .. .   .|  .  ..| .||||| |||| |. |. |||   |  |  . .|||||||||   || ..||.. |...   ..||||||| 
nvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhet

EFVNKVYGFYEECQKRYqSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHD--------------GKERLVADLLWADPISGLSGFMENNRGAGCG
  |||.|||| ||| .|  | ..  || .|| .|..|||....|||||||||                     |. ||||.||     |.. . ||    
psvnkiygfyvecqyky.gvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisym

FGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRP
||.  | . |  ...||| |||||||||||..|||.|.|.|| | || || |.|| .  . .|| ||. | |
fgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_PPP6C_pd Subfamily PPP6C 25-280 3.2e-72 236.1 In-house 13-281 (290) alignment 
Range on Protein: 25-280
Range on HMM: 13-281/290.0
EVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHEC
. ..|  . || || ||.. .. ... ...|. ||||||||| ||. ||. ||  | ..|.||||.|||| .|.||. .||. |.|.| .. |||||||.
kylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhes

EFVNKVYGFYEECQKRYQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDGKER--------------LVADLLWADPiSGLSGFMENNRGAGCG
  . .|||||.||...| ..  .  . .||. |... .| ...||.||||||     ..               ..||.|.||   .. ..  .||||  
rqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagyl

FGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEIL
||.  . . ..  .|.|||||||.|..|....   ||||..||| || .  | |. .. ... . .....
fgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklf
subfamily_PPP3C_pd Subfamily PPP3C 25-271 2.6e-67 220.5 In-house 34-311 (452) alignment 
Range on Protein: 25-271
Range on HMM: 34-311/452.0
E-----VITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLR
       ..|  .||... | ...|..|...|..||| |.||||||| |||.||. || | ...||||||||||| ||||... |.| |...| .|||||
hflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllr

GNHECEFVNKVYGFYEECQKRYqSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDG--------------KERLVADLLWADPISGLSGFM----
|||||  . . . | |||...| | ... |. . |. |||  |. .. ||.||||||                  .  .. ||||.||.   . ..    
Gnhecrhlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteek

--EN-NRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAG------RKLVTIFSAPHYCGQFDNCAAFMSCDE
  .|  ||  . ..  || .   . .|  | |||.. ..||. .          |.|.|||| |.. ..| || .  ..
fvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 25-180 9.8e-52 168.8 In-house 14-168 (290) alignment 
Range on Protein: 25-180
Range on HMM: 14-168/290.0
EVITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHEC
. ...  .|..|. . ....   ...|..||| . ||||||. .||| |.  | ||  ..||||||||||  |.|  .||. ||.... .. |||||||.
dafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhev

EFVNKVYGFYEECQKRyQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDG
  ||..|||.||  .. .. |..  .||||. |.||  ...||||||||.|.  . 
rkvnrlygfkeelark.rgsrlwkqyqdvfaelslcarvgrkilcmhggisqkies
subfamily_PPP1C_pd Subfamily PPP1C 26-284 3.3e-107 350.9 In-house 9-280 (282) alignment 
Range on Protein: 26-284
Range on HMM: 9-280/282.0
VITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECE
 ..|  . .||. | .....|  ..|..||.|..||||||. ||||||...| ||..||||||||||||..|.||||||||||.|.| ||||||||||. 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

FVNKVYGFYEECQKRYQSVrMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHD--------------GKERLVADLLWADPISGLSGFMENNRGAGCGF
 .|..||||.||..||..  .. .|.||||.|||. |...||||.||||||. .               .. |..||||.|| .   |. ||.||    |
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTS
|.|.| |......||||.||||||.||||||| |.|||.||||.|||.|||..| .| ||.| .||.||.|..
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 26-282 3e-94 308.6 In-house 7-282 (284) alignment 
Range on Protein: 26-282
Range on HMM: 7-282/284.0
VITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWP------PTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLR
...|  ...|   | ..| ..|  .|..||.|..||||||| ||| |..  |||         .||||||||||| |||| |.||.|||...| ..||||
llkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllr

GNHECEFVNKVYGFYEECQKRYqSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSH------DGKE--------RLVADLLWADPISGLSGFMENNR
||||   ||. ||||.||.||| |.... |||  || .||| ....||.|||||.|         |  |         ..||| |||| . ..|. | .|
gnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykespr

GAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRP
|||  || .|| . .  |||||. ||||||.||||||| |||||||||| ||||.|| || .. ||.| .|| .|.|
gagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_PPP5C_pd Subfamily PPP5C 26-274 2.2e-71 233.5 In-house 33-300 (322) alignment 
Range on Protein: 26-274
Range on HMM: 33-300/322.0
VITEGRVLKLLDLALDVFKRQKSMVEMNAP----IKVCGDIHGQFPDLLRLFHRGGWPPT-ANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRG
 . .  .||.|  | ...|.. |.||.. .    . ||||||||| ||| .|.  | | .   ||| ||.|||| ||.|.|..||..|. .| ..|| ||
klhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrG

NHECEFVNKVYGFYEECQKRYQSvRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSH---------------DGKERLVADLLWADPISgLSGFMENNR
||| . .||.||| .|....|.. ...  |..|||||||. .| .|.| .||||  ..               . .| |. .|||.|| .  .| .. .|
nhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskr

GAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSC-DEKLQ
| |. || |   | . . .|.|| |.|.| ..|||.    ||.|.|||| || | .| .||..  ...|.
GvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 26-81 1.5e-11 37.0 In-house 8-63 (317) alignment 
Range on Protein: 26-81
Range on HMM: 8-63/317.0
VITEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPT
...|  ...|   | ..| ... ..|..||....||||||| ||| |..  ||| .
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpls
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 28-284 1.9e-82 269.7 In-house 9-278 (281) alignment 
Range on Protein: 28-284
Range on HMM: 9-278/281.0
TEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFV
|.  . ...  .  .|  .|..||...||.| ||.|.|| || |||.  | .|   ..|||||||||  |.|...||...|.... ...|||||||   |
tkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasv

NKVYGFYEECQKRYqSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSH----DGKER----------LVADLLWADPISGLSGFMENNRGAGCGFGR
||.||||.||. .|  . ... ||  || ||. .|||...|||||||||      . ..|          || ||||||| .   ....  ||..  ||.
nkiygfyvecvtky.GeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGk

DAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTS
. | .||  ....|| ||||||||||| ..||||.|.||.| || .. |.|| .  ||.|. |.  | |.|
nvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 28-282 1.4e-60 198.0 In-house 7-299 (302) alignment 
Range on Protein: 28-282
Range on HMM: 7-299/302.0
TEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWP-----------PTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLF
..  .|.|..   . .|..|...|. .|. . |||||||.||.|..                  .  ..|||||||||. ||| | |..|.|| .| |  
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LLRGNHECEFVNKVYGFYEECQKRYQ---SVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDG---------------KERLVADLLWADPISG--
|||||||.. .|  ||| || ..|.      ...  |..|| ..||  |. .||||.|||.||  .                .. |  |||.|||. .  
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

------LSGFMENN-RGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRP
         ...|. ||    |   || .||  . |.|| ||||..  |. ||| .||.|||||| |  . ||  | .  | . . |  .||.
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 28-282 2.8e-60 197.1 In-house 8-300 (302) alignment 
Range on Protein: 28-282
Range on HMM: 8-300/302.0
TEGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWP-----------PTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLF
..  .|.|..   . .|..|...|. .|. . |||||||.||.|..                  .  ..|||||||||. ||| | |..|.|| .| |  
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LLRGNHECEFVNKVYGFYEECQKRYQ---SVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDG---------------KERLVADLLWADPISG--
|||||||.. .|  ||| || ..|.      ...  |..|| ..||  |. .||||.|||.||  .                .. |  |||.|||. .  
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

------LSGFMEN-NRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRP
         ...|  ||    |   || .||  ..|.|| ||||..  |. ||| .||.|||||| |  . ||  | .  | . . |  .||.
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
PPP_3 29-280 1.9e-92 302.1 In-house 4-269 (271) alignment 
Range on Protein: 29-280
Range on HMM: 4-269/271.0
EGRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVN
|  . .|.. . .... ....||..||..||||||||. |||.||. || .|. .||||||||||| .|.|...||||.|.|.| ...|||||||.. .|
enelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqin

KVYGFYEECQKRYQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDG--------------KERLVADLLWADPISGLSGFMENNRGAGCGFGRD
|||||..|..|.... ......|.||..|||. || .|.|..||||||| .               .| .. |||. .. .  .|. ...||||. || |
kvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgpd

AVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEIL
.. ..... ||.||.|||.....|||... .|.||.||||.||....| .|... .|.|...|..|
vteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
PP2Ac_SM00156 30-283 1e-99 326.0 In-house 4-270 (271) alignment 
Range on Protein: 30-283
Range on HMM: 4-270/271.0
GRVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVNK
  ||.||. . ...|..|..||..||. |.||||||. |||||....| ||. .|.||||||||| .|||.|.||.|.|...| ...|||||||.. |||
eevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnk

VYGFYEECQKRYqSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSP--------------SHDGKERLVADLLWADPISGLSGFMENNRGAGCGFGRDA
.|||.||.. .| . ...  |...|..|||. |. .|||||||||||               .. .| |..||||.|| .  .||  . ||... ||.||
iygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgeda

VLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
| .... ..|.||.|||.||..|||||| .|||||||||.||..|.| ||... ...|..|.| |...
vkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 31-283 1.7e-96 316.0 In-house 7-274 (284) alignment 
Range on Protein: 31-283
Range on HMM: 7-274/284.0
RVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVNKV
 |  ||  |...|..|  ..|.|.||..|||||||| |||||| . |.|  |||||||||||||.  .|||.||.|||| ||  .|.||||||| ..||.
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYEECQKRYQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSH-------------DG--KERLVADLLWADPISGLSGFMENNRGAGCGFGRDA
||||||||.||.   ....|. ||  .||  |. ..|||||||.|                |    . |  |.||.||     |.  | ||    || ||
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

VLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
. |.   ...||. |||||||||||||| |.|||||||| |||||||.|| |  ...| ||| .||| 
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrpr
PPP_1 31-180 5.4e-67 218.8 In-house 5-154 (264) alignment 
Range on Protein: 31-180
Range on HMM: 5-154/264.0
RVLKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVNKV
 . .|.. . ....... ..|....|.||||||||| |||.||. || .|. |||||||||||| .|.|...||||.|.|.| .|||||||||.. |.||
elaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkv

YGFYEECQKRYQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDG
|||..|..|...| ... ...|||..|||. || .|||..||||||. | 
ygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldl
subfamily_PPP7C_pd Subfamily PPP7C 32-178 3.1e-41 134.3 In-house 38-191 (383) alignment 
Range on Protein: 32-178
Range on HMM: 38-191/383.0
VLKLLDLALDVFKRQKSMVE----MNAPIKVCGDIHGQFPDLLRLFHRGGWPPTA-NYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEF
||..|  | .|.|. ... .    .   . ||||.||.. ||| .... | | .  .|.| ||.||||. |.| ...|||. . .| ...| |||||   
vllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhi

VNKVYGFYEECQKRY--QSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSH
.|  |||  | ...|  .. .. . ..||| ||||. || .||| .|||.| . 
lnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdkt
subfamily_PPPLV_pd Subfamily PPPLV 33-269 1.1e-49 162.4 In-house 3-276 (290) alignment 
Range on Protein: 33-269
Range on HMM: 3-276/290.0
LKLLDLALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLR---LFHRGG-WPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVN
| | | |.|..  .. ..|...|. | ||.||.. ||      . | |     |..|||||||||| ||.| |  ||| || .|  ..||||||| | | 
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

KVYGFYEECQKRYQ--SVRMFTAFQDVFNWLPLCGLIANKILCMHGGL----------SPSHDGKER---------LVADLLWADPISG-----------
. . .. |.. ..      .. ||..||..|||   | .|..|.|.|.          |. .|  ||         |  |.||.|| ..           
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

LSGFMENN-RGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSC
  ||..|. || |. |. ||. .      |. . |||.| . |...  . .|.|.||. .|||. .. |  .  
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvd
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 39-286 2.3e-65 213.8 In-house 32-295 (307) alignment 
Range on Protein: 39-286
Range on HMM: 32-295/307.0
ALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQ
|  .|  .|..|... |  | ||.|||| ||. .|   | || . |.| ||||||| .|.|.|.||..||. .| |. |||||||   ||| ||||||| 
aqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecv

KRYQS--VRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDGK--------------ERLVADLLWADPISGLSGFMENNRGAGCGFGRDAVLKVCSD
         ... || .|| ||.  ||| |||||||||||.                    .| |.|||||   .  .    ||.|  || . .  ||  
tsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckr

FKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTSGR
. ..|| ||||.. |||  ..||||.|||||| ||  . |. . .  || |      . |.|  
lgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesen
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 39-80 2e-07 23.5 In-house 23-64 (339) alignment 
Range on Protein: 39-80
Range on HMM: 23-64/339.0
ALDVFKRQKSMVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPP
| ..   .  .....||| | ||||||| ||| ..   ||| 
areliwsepiflkleapicvmgdihgqfddllamldmngwpl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 49-284 2.1e-63 207.4 In-house 2-257 (263) alignment 
Range on Protein: 49-284
Range on HMM: 2-257/263.0
MVEMNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQKRYQSVRM--
..|..|||..||| |||. ||||.|   |    ..||||||||||| .|.| |.||.. |. .| ...||||||| . .|| |||. | .||.|   .  
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

--FTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDG---------------KERLVADLLWADPISGLSGFMENN-RGAGCGFGRDAVLKVCSDFKLDLI
  .  |..||...||| .....|||||||.||                      | .|||||||     ||  |. |     ||.  |  .|  . .|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTS
 ||||||. || ||| |.|.|.||| .|  .. | || .  .. |. ||  |.|  
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
subfamily_YNL217W_pd Subfamily YNL217W 53-159 2.6e-07 23.4 In-house 9-120 (235) alignment 
Range on Protein: 53-159
Range on HMM: 9-120/235.0
NAPIKVCGDIHGQFPDLLRLFH--RGGWPPTANYLFLGDYVDRGRFSIETIVLLlaykvkFPGNLFLLRGNHECEFVNK------VYGFYEE-CQKRYQS
.  . | ||.|| . .|..|..   ||  . .  ...|| ...|  |.|.. ..         .   ..||||   . .        |. .    .... 
gkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsf

V--RMFTAFQDVFNWLPL
.  ..  |  .    |. 
lesklskadmeyarelgf
Metallophos Calcineurin-like phosphoesterase 55-235 8.5e-44 143.2 Pfam-A 2-199 (200) alignment 
Range on Protein: 55-235
Range on HMM: 2-199/200.0
PIKVCGDIHGQFPDL----LRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLL--LAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQK---------
.| |.||.||.. ||    |.|.. .. ..  ..|||||.||||. |.||. ||  |..|...|...||||||||. ..|..|||..|. |         
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RYQSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDGKERLvadllwadpisglsgfmennrgAGCGFGRDA
                         .   . . .....|..|||. |. .|||..||.||.| .  .                        ... ||.||
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi......................gselfgpda

VLKVCSDFKLDLICRAHQVV
. | . . ..||..|.|. .
lekllekygvdlvlrGHtHk
PPP_2 56-234 4.3e-65 212.1 In-house 1-197 (198) alignment 
Range on Protein: 56-234
Range on HMM: 1-197/198.0
IKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQKRYQSVRMFTAFQDVFN
..||||.|||. |||.||. |. .|. .|||||||||||..|.|...||||.|...| ...|||||||.. |||||||..|..|.... ......|.||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

WLPLCGLIANKILCMHGGLSPSHDG--------------KERLVADLL----WADPISGLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQV
.|||. || .|.|..|||||.. .               .| .. |||    . || .  ... ...||||. ||.|.. ......||.||.|||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 56-234 8.6e-62 201.7 In-house 1-196 (197) alignment 
Range on Protein: 56-234
Range on HMM: 1-196/197.0
IKVCGDIHGQFPDL-LRLFHRGGWPP-TANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQKRyQSVRMFTAFQDV
. |.||||||. || |.|.. || |. . .|.||||||||| .|.|...||||.|...| ...|||||||.. .|..|||..|.... .. ... ..|||
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FNWLPLCGLIANKILCMHGGLSPSHD---GK------------ERLVADL-LWADPISGLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQV
|..|||. ||..|.|..|||||.. .    .            | .  || ||.|| .  .|. .. ||||. ||.|.. |.... .|.||.|.|..
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 56-235 1.3e-59 194.5 In-house 1-199 (199) alignment 
Range on Protein: 56-235
Range on HMM: 1-199/199.0
IKVCGDIHGQFPDL-LRLFHRGGWPP-TANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQKRYQSVRMFTAFQDV
. ||||.|||. || |.||..|| |. . .|.|||||||||..|.|...||||.|...| ...|||||||.| .|..|||..|....|.. ... ...||
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNWLPLCGLIANKILCMHGGLSPSHDG---------------KERLVADL-LWADPISGLSG-FMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVV
|.||||. ||..|.|..||||||. .                ..   ||| ||.|| .  .| . .. ||||. ||.|.. |.... .|.||.|.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 82-284 2.3e-83 273.0 In-house 101-316 (317) alignment 
Range on Protein: 82-284
Range on HMM: 101-316/317.0
ANYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQKRYqSVRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSH---
 .||||||||||| |||| ..||.|.|...| ..||||||||   ||. ||||.|..||| |.... ||| .|| |||| ....||||||||.| .    
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldl

---DGKE--------RLVADLLWADPISGLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFM
   |  .         ..||| |||| .  .|. | .||||  || .|| . .  ..|||. ||||||.|||||||.|||||||||| ||||.|| || .
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

SCDEKLQCSFEILRPTS
| |.||..|...||| |
svdkklkisinvlrpes
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 83-284 1.4e-62 204.8 In-house 121-335 (339) alignment 
Range on Protein: 83-284
Range on HMM: 121-335/339.0
NYLFLGDYVDRGRFSIETIVLLLAYKVKFPGNLFLLRGNHECEFVNKVYGFYEECQKRYQSvRMFTAFQDVFNWLPLCGLIANKILCMHGGLSPSHDGK-
 ||||||||||| ||.| ..|| | |. .|  ..|||||||   ||  |||| | . ||.. ... .||..|| .|.| .| | |.|||||.|       
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsfn

-------------ERLVADLLWADPISGLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMS
               ...|| ||||     |.    |||   ||  |.  .   . |... | ||||.|||||| ||.|||||||| |||| || || .|
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

CDEKLQCSFEILRPTS
 |.||. | ...|| |
idkklkisinvfrpes
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 180-283 4.1e-23 74.8 In-house 184-289 (290) alignment 
Range on Protein: 180-283
Range on HMM: 184-289/290.0
GKERLVADLLWADPISG-LSG-FMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSF
 .| |. |||||||         ..  |.    ||.... ...  . |.|| |||.| ..|..|   .||||.||||.|.|.  |. | .   | |. |.
cdeglqvdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsi

EILRPT
 .|.| 
vvlkpr
subfamily_PPP7C_pd Subfamily PPP7C 183-275 3.3e-18 58.5 In-house 235-327 (383) alignment 
Range on Protein: 183-275
Range on HMM: 235-327/383.0
RLVADLLWADPISGLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQC
| | |.||.|| .    . .  ||.|. || |   |. . ..|.|. |.|.  ..||||   .|..|||||  |  .  |  |..   ..|. 
rqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltp
PPP_1 187-268 4.3e-23 74.9 In-house 182-263 (264) alignment 
Range on Protein: 187-268
Range on HMM: 182-263/264.0
DLLWADPISGLSGFMENNRGAGCGFGRDAVLKVCSDFKLDLICRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMS
| |. |. .  ... ...||||. ||.|.. |... ..|.||.|||.|...||||.. ||.||||||. |. ...| .|...
dillsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk