Gene C34D4.2 in Caenorhabditis elegans

Synonym: CELE_C34D4.2, CELE_C34D4.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP033_AA protein Get Run
CeleP033_AA_38-313 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 34-316 2e-104 342.1 In-house 14-297 (299) alignment 
Range on Protein: 34-316
Range on HMM: 14-297/299.0
GWTPGHCQKLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVF
| . ..  |  .|.||..||  |..|| .... ||..||...|||.|||| ||| ... .|.||....||||||||||   .|.|.||..... .|.. |
gmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperff

LLRGNHESRPVNMQYGFFMECRKRF-SNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMYAE
.||||||   .|  |||. || ||. |  |. .|| ||  |||. ... .|.|||||.|  | .| || .. || | |.  .  || ||||| ... .  
mlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwla

SQRGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPDLKK
  ||   ||| . |.. ...  ..|| |||||| |||||||...|||||||| ||||.||.||.| |||.|||.|.|..|  |.
nvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 35-96 1.2e-17 57.0 In-house 2-63 (339) alignment 
Range on Protein: 35-96
Range on HMM: 2-63/339.0
WTPGHCQKLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWP
||   . .||   || .||.||||. | . . |.|.||. . ||.|||..||||.|..||||
wthktsldlfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 37-314 2.1e-171 561.8 In-house 1-284 (284) alignment 
Range on Protein: 37-314
Range on HMM: 1-284/284.0
PGHCQKLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWP------PETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPD
|..||||..|||||.|||||||.|||...|||..|||||.||.|||.|||||||.|||||       |.|||||||||||||||||||.|||||..|.||
pvncqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpd

KVFLLRGNHESRPVNMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMY
||||||||||||||||||||..||.||.|.|||.||||||..||||||||.|||||||||||||.||.||||.|||.|.||||||||||||||.|....|
kvfllrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegy

AESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPDL
.||.||||.||||.|||.||....|.|||||||||||||||||||.|||||||||||||.||.|||..||||||.||||..|||
kesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkpdl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 37-96 2.1e-30 99.0 In-house 2-61 (317) alignment 
Range on Protein: 37-96
Range on HMM: 2-61/317.0
PGHCQKLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWP
|..||.||.|||||.|||||||.|||...||||.|||.|.||.|||.|||||||.|||||
pkkcqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 39-315 3e-117 383.9 In-house 19-296 (298) alignment 
Range on Protein: 39-315
Range on HMM: 19-296/298.0
HCQKLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGN
.  |  .|... .|.  |...| |... .|..||.|.|||.|||| ||| |.. .|.||.. ||||||||||| ...||| ||.||.| .|...||||||
kltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGn

HESRPVNMQYGFFMECRKRF-SNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGA
||   .| .|||. ||..|. | .|| .|| .|  .||.|.....|.|||||.|. |. | || ...|| | ..  . .|| ||||. ... .||..||.
heceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGv

GRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPDLK
. |||...||..|.. ...||||||||| |||||||...|||||||| ||||.||.||||.|||.||.||.|..|  |
svvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekk
0045823 Metallo-dependent phosphatases 39-313 5.1e-104 341.5 In-house 38-324 (473) alignment 
Range on Protein: 39-313
Range on HMM: 38-324/473.0
HCQKLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGN
  ..|. |..|..|...|.|...| .  |||.... ..||.|||..|||.|||..|.|||....||||.|||||.|.||. ||.|.....|..|||||||
kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGN

HESRPVNMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQM-------YA
||.| .|  |||. |......  ||..|.  . ..||.||. .||...|||.| ||  | |....|||...|| |.. || |.||. . .        . 
HElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddgdgllrlrffg

ESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQ------LVTIFSAPSYCGQMDNAAAVMTVDEELvCSFTVMRPD
 |.|||| .||..||..||. ..| |.||.|..|..|||.. |..      ..|.|||| |||...| |||...||.| .||....|.
nsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdps
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 39-315 1.1e-101 332.7 In-house 4-277 (280) alignment 
Range on Protein: 39-315
Range on HMM: 4-277/280.0
HCQKLFDEKELIQLCyraREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGN
.| |  | ...|. |   ....  ..  .|..|||..|||||||| ||| |..  ..||...||||||||||| . .||| ||.||.| .|.. ..||||
acikeadidrviekc...kkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgn

HESRPVNMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGAG
||   .| .|||  |...|.|.|||. ||  .  .||.|.|| .|.|||||.|..|| | .| .. || | .|  .  || ||||.  .  .||..||. 
hevisinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

RVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPDLK
 .|||. ||.. .  ...|..| |||| ||||||||..|||.|||| |.|..||.|||. |||.|. || |..|.|.
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalr
0049330 Metallo-dependent phosphatases 39-312 5.5e-101 330.7 In-house 25-298 (309) alignment 
Range on Protein: 39-312
Range on HMM: 25-298/309.0
HCQKLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGN
...||..|.||..|...|.|.... .  |||.... ..||.|||..|||.|||..|.|||....||||.|||||.|.||. ||.|...|.||.|||||||
lklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGN

HESRPVNMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGAG
||.| .|. |||. |.  ...  |...|.  . ..||.||. .||.|.|||.| ||. | |....|||...|. |...||.|.||. .. ..|...||.|
HElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprglg

RVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRP
 |||. ||..||....|.|..|.|..|..||..|.|..|.|.|||| |||...|..||...||.||.||....|
vvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfep
subfamily_PPP6C_pd Subfamily PPP6C 39-304 4e-78 255.5 In-house 11-275 (290) alignment 
Range on Protein: 39-304
Range on HMM: 11-275/290.0
HCQKLfDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGN
.|. |  |..| .|| .  ... ..     ...|| .|||.|||. ||. |.   |  |.|.|.||||.|||| .|.| ...|.. .. .||.. |||||
kckyl.pendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgn

HESRPVNMQYGFFMECRKRFSNAL-YDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDaTIQMYAESQRGA
|||| .   |||. || ... ||  .  .   |  ....|.. ....|.|||.| |.  | |.  .||  ..|  | ..|| |.||.  .. .| |.|||
hesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprga

GRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELV
| .||.. .|.|... .|.|..||||.|..|.... | .|||..||| || .  | |........  
gylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaee
0053225 Metallo-dependent phosphatases 40-312 2.6e-93 305.6 In-house 18-290 (293) alignment 
Range on Protein: 40-312
Range on HMM: 18-290/293.0
CQKLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNH
..||..|.||..|.. |.|...| .  |||.... ..||.||...|||||||. |.|||....||||.|||||.|.||. ||.|...|.||.|.||||||
llkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNH

ESRPVNMQYGFFMECRKRF-SNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDaTIQMYAESQRGAG
|.. .|. |||. |.  .. . .|.|...  . ..||.|.. .||...|||.| ||. | |.....||...|. |...|| | |||  .  .. |.||.|
ElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrglg

RVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRP
 |||. ||..||....|.|..|.||||.|||... |..|||.||||.|.|...|..||...||.||..|....|
vvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_PPP2C_pd Subfamily PPP2C 40-313 3.3e-85 278.8 In-house 14-286 (290) alignment 
Range on Protein: 40-313
Range on HMM: 14-286/290.0
CQKLfDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNH
|..| .|.|. .|| .|.|.. |..   |.|.|| .|||.|||. ||| |. . |  |.|.||||||||||| .|.| ..|| | .| ..... .|||||
ckql.eesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnh

ESRPVNMQYGFFMECRKRFSNA-LYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDaTIQMYAESQRGAG
||| .   |||. || ....|| ..  |   | ..||.|.| ..| |.|||.|  .  | .. ...|  .||. | ..|| |.|||   . .. |.||||
esrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgag

RVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPD
  || .  .|| .| .|.|..||||.||.||..  ||..||||||| || .  | ||.. .|..|  ||  . | 
ytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
subfamily_PPP5C_pd Subfamily PPP5C 41-307 1.1e-78 257.4 In-house 31-303 (322) alignment 
Range on Protein: 41-307
Range on HMM: 31-303/322.0
QKLFDEKELIQLCYRAREVFWKNNVKLE----LKAPVKICGDLHGQYEDLLALLELNGWPPET-KYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLL
|| . .|  ...  .|.|.. |    .|     .  . .|||.|||. ||| ..|||| | |.  ||| ||.|||| ||.||| .|.....|.|...|| 
qkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhffls

RGNHESRPVNMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGI-SEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMyAESQ
||||||  .|  |||  |..........| |.  |  .||. |. .|.. .|||. ||| | | .| |..| .. |. |.. .| |.||. .  . ..|.
rGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGr.spsk

RGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTV-DEELVCSF
|| |  || .  ||||.. .|||..|.|.| ..|||.  | .|.|.|||| || ||.| .|..|. ...|   |
rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkf
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 41-313 1.3e-75 247.1 In-house 13-289 (290) alignment 
Range on Protein: 41-313
Range on HMM: 13-289/290.0
QKLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHE
 . | .|.....  ...|..    . ||..||. | ||.||| ..||  ..  | ||. |.||||||||||. |.||  ||| |..... || |||||||
ldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

SRPVNMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCD--VPDIGVIADLTWADPDA----TIQMyaESQ
 | ||  |||  |  .. .. |.  .|  |  ..||| |. ||.|||||||...     |  ...|      | |.. || ||||.     ||..  . |
vrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtial..nkq

RGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPD
|.   ||| ... ..|..  |.|.||||.|  .|..|  |..|||.|||| |.|.  |  |..|| | |  |..|..| 
raisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 41-312 2e-68 223.8 In-house 3-299 (302) alignment 
Range on Protein: 41-312
Range on HMM: 3-299/302.0
QKLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWP-----------PETKYLFLGDYVDRGPFSIEVISLLFAYQVLHP
.| ....||..|.    | . |..   |. .|| | ||.|||.|||. .|  .               . |..|||||||||. ||| |.|.||..||.|
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyp

DKVFLLRGNHESRPVNMQYGFFMECRKRFSNAL----YDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPC-DVPDIGVIADLTWADPD
 .  |||||||.. .|. |||  |  .|....     .. |. .|  ||| |.| .||.|.|||||. |  | ...|..||  .| .  .  || .||| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

A---------TIQMYAESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRP
          . .   .  ||   ||   ||... .   |.|.|||||..  |. ||||..|.|||||| |  ..||  ||. || .   | .|.|.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 41-312 3.8e-68 222.9 In-house 4-300 (302) alignment 
Range on Protein: 41-312
Range on HMM: 4-300/302.0
QKLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWP-----------PETKYLFLGDYVDRGPFSIEVISLLFAYQVLHP
.| ....||..|.    | . |..   |. .|| | ||.|||.|||. .|  .               . |..|||||||||. ||| |.|.||..||.|
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyp

DKVFLLRGNHESRPVNMQYGFFMECRKRFSNAL----YDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPC-DVPDIGVIADLTWADPD
 .  |||||||.. .|. |||  |  .|....     .. |. .|  ||| |.| .||.|.|||||. |  | ...|..||  .| .  .  || .||| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

A---------TIQMYAESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRP
          . .   .  ||   ||   ||... .   |.|.|||||..  |. ||||..|.|||||| |  ..||  ||. || .   | .|.|.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 42-312 1.5e-96 316.1 In-house 21-294 (297) alignment 
Range on Protein: 42-312
Range on HMM: 21-294/297.0
KLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHES
|.  |. ...|   | .|| ...  .|..||.|.|||.|||. ||| |.   |||| ..||||||||||| |||| | ||.||.|  | ..|||||||| 
kviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhec

RPVNMQYGFFMECRKRF-SNALYDAFQLAFYCMPLCAVVSDKIICMHGGISE---DLVDLRQLDKVERPCDVPDiGVIADLTWADPDATIQMYAESQRGA
  ||  |||. ||.||. |  .| |||  |  .||. ....||.|||||.|    . . |  | |.||. .  . ...||| |||| . .  . | ||||
efvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadllwadpisglsgfmenqrga

GRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRP
|  || .|| |     .|.||.|||||| ||||||| |.|||||||| ||||.||.||.|..||.| ||| ..||
gcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrp
subfamily_PPP4C_pd Subfamily PPP4C 42-310 2.2e-85 279.4 In-house 14-282 (288) alignment 
Range on Protein: 42-310
Range on HMM: 14-282/288.0
KLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHES
.|  |.|. .|| .|||.. ...   ....|| .|||.|||..||| |....|  |||.||||||.|||| .|.| . || |..| .||.. |.||||||
elikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhes

RPVNMQYGFFMECRKRFSNA-LYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDAtIQMYAESQRGAGRV
| .   |||. || ... .| ..      |  ..|.|.. .||.|.|||.| ..  | ..  ..|  .||. |...|| |.||.  .. .| | |||| .
rqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdped.aegwavsprgagyl

FGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVM
||...|..| .. ..||..||||.||.|| .  .....|..||| || .  | ||.. .||||   |...
fgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_PPG1_pd Subfamily PPG1 42-309 3.7e-71 232.8 In-house 12-292 (300) alignment 
Range on Protein: 42-309
Range on HMM: 12-292/300.0
KLFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHES
.|. |  . .|... .|.. |.    |...|| . ||.|||. |.| .... |  |.|.||||||||||| .|.| |||| . .. .| .. ||||||||
ellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhes

RPVNMQYGFFMECRKRF--SNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPD-----------ATIQ
| .   |||. || ...   . ... .   |  . |.|.. ..| |.|||.| .   . |.  ..|  .||. | .||| |.||.              |
rqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregq

MYAESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTV
 . .||||||  .| . |.|||.. ... ..||||....||. . | .| |..||| || .  | |... . | .   | |
hfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnv
subfamily_PPP1C_pd Subfamily PPP1C 43-314 5.7e-120 392.7 In-house 9-280 (282) alignment 
Range on Protein: 43-314
Range on HMM: 9-280/282.0
LFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESR
 . |.|. .|. .|||.. .. . |||.|||||.||.||||.||| |.| .| |||..||||||||||| .|.|.| ||.||.. .|...||||||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

PVNMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGAGRVFG
 .|. |||. ||..|.|. |. .|. .| |.||.|.|..||.|.|||.|..| .| |..|..||..||. |...|| |.||| ... ..|..||   .||
sinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfg

AEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPDL
...|.|||. ..|.|.||||||| |||||||.|||||.|||| |||..|||.||..|||||..||....|  
kdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 43-314 1.9e-89 292.4 In-house 9-283 (287) alignment 
Range on Protein: 43-314
Range on HMM: 9-283/287.0
LFDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESR
 |..|.....  ...|..   .. ||..||..|.||.|||..||| ...  | .|...|||||||||||. |.||. |||..... | || ||||||| .
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevk

PVNMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDI--GVIADLTWADPDATIQMYA-ESQRGAGR
 .| .|||  | ...... ||  |.  |  .|||| || .|.|||||||..|  | .|  ...|    .   |.. || ||||.   . .. . .|.   
kinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisv

VFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPDL
||| . | ..|..  ..|.||||.|. .||.|..|..|||.|||| |.|.  | .||..|.. |  ||.|..|. 
vfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkped
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 44-313 6.3e-87 284.4 In-house 8-277 (281) alignment 
Range on Protein: 44-313
Range on HMM: 8-277/281.0
FDEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRP
. ..|.... . .. .| ...   |...|... ||||.|..|| .|.|| | .||....|||||||||| |.||. |||.... ..|...|||||||   
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

VNMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGAGRVFGA
|| .|||..||  ..   |.  ||  |  .|. | .. .. |||||.| .|. | .| .  .|.. .| |.. || |||||   . . .| ||.. .|| 
vnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGk

EAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPD
. |..   .  .||..||||||.|||| .. |.|.|.||.| || .  |||||..|||.|  |.  . |.
nvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
PP2Ac_SM00156 45-312 6.6e-107 349.6 In-house 2-269 (271) alignment 
Range on Protein: 45-312
Range on HMM: 2-269/271.0
DEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPV
...|...|. ...|.. .... .|..||| ..||.|||..||| ||||.| |||.||.||||||||||.|||||.||||...|.|.||.||||||||..|
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGAGRVFGAE
|. |||. |.. . .. .|. |. || ..||.|.|..||.|||||.|..|  |....|..|. . |. |...||.|.||. . . .. |.||.. |||..
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

AVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRP
|||.||....|.|..|||.||..|||||||..|||||||| ||....|.|||..|...| .|. ....
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
PPP_3 45-311 1.3e-97 319.0 In-house 3-270 (271) alignment 
Range on Protein: 45-311
Range on HMM: 3-270/271.0
DEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPV
.|.|| .|. ...|.. |... .|..|||..|||.|||..||| | .  | .||||||||||||||| .|.||. ||.|.....|..|.||||||||| .
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

NMQYGFFMECR-KRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGAGRVFGA
|  |||  |.  |. .. .|...|  | ..||.|....|....|||.|...  | |. | ||...||. | . ||.. ..... .....|.|||| .||.
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgp

EAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMR
.....||....|.|..|||.....|||...|...||.|||| ||....||.|.....|.| ..|....
dvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_PPZ_pd Subfamily PPZ 45-312 6.6e-93 304.5 In-house 26-293 (300) alignment 
Range on Protein: 45-312
Range on HMM: 26-293/300.0
DEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPV
 ..|..|.|..|||.|  .   |||  .||| ||.|||| ||| |.   |.|| ..|||||||||||  |.| | ||..|.. .|...||||||||   |
knseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanv

NMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGAGRVFGAE
   |||. ||..|    .. .|  .|  .||.|.|. ||.|.|||.|  |  . .. .| || ||||.|.| || |.||  . . . . .||   ..   
trvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkv

AVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRP
|..||||   ..||.||| || |||||| || |||.|||| |||..||  |||.| | |.||| .. |
ainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_PPP3C_pd Subfamily PPP3C 45-302 5.7e-75 245.8 In-house 42-312 (452) alignment 
Range on Protein: 45-302
Range on HMM: 42-312/452.0
DEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPV
.|.. ...  .| ... |..  ||..||. ..||.|||. ||| |.|..| | .||||||||||||| ||||..  |.| .. .|...||||||||.| .
eeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhl

NMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQ-------MYAESQRGA
   . |  ||....|...|||.  .| ..|| |.. .. .|.|||.| .. .| ...|..|  ..|  | . || |.||    .          .| || 
teyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGc

GRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFAD------RQLVTIFSAPSYCGQMDNAAAVMTVDEE
  ... .|| .||.. .|  ..|||..  .||. . .        |.|.|||| |..  .| |||. ....
syfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 45-313 2.9e-69 226.6 In-house 21-292 (307) alignment 
Range on Protein: 45-313
Range on HMM: 21-292/307.0
DEKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPV
  .|. .. | |. .|  ..  ...  |. . ||||||..||. .. | | |||| |.| ||||||| .|.|.| |||.|.. .|... |||||||   |
tkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarv

NMQYGFFMECRKR---FSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGAGRVF
| .|||. ||        . ..  || .|  .|. |... ||.|||||.|  |  | .| .  .|   |  |.. |. ||||| ..  .  | ||.|  |
nkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftf

GAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPD
|.. .    .   .||..||||...|||  .. |.|.|||||| ||    || .|. ||| |      . |.
gtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpe
PPP_1 46-298 2e-91 298.9 In-house 3-263 (264) alignment 
Range on Protein: 46-298
Range on HMM: 3-263/264.0
EKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPVN
|.||..|. ...|.. |... ||.......|||.|||..||| | .  | .|||.||||||||||| .|.|.. ||.|... .|...|||||||||| |.
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

MQYGFFMECR-KRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLT-------WADPDATIQMYAESQRGA
  |||  |.. |..|. .|.... .| ..||.|.. .||...|||.|..|  | |  |..|  .||. | . ||.       . |.... .. |.|.|||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMT
| .||.....|||....|.|..|||.|...||||...|..||||||. |. ...|..|...
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 46-312 2.9e-76 249.6 In-house 8-274 (280) alignment 
Range on Protein: 46-312
Range on HMM: 8-274/280.0
EKELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPVN
 .|.| .      .| ...   | .||.|. ||.| ||.|.  |..| |  || | .||||||||||  |||. |||. .. . |...|||||||.  ||
gheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvn

MQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGAGRVFGAEA
  |||..||. ..  .|.  || .|  ||.....| ...|||||.| .|..|  . .. |||.  | |.. || |.||    . .  | ||   .||   
kiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgv

VKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRP
|..  ..  ..|..|||||| ||||..| |.|.|.|| | || |. |||||. .. .|  ||  . |
veqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 47-316 6.6e-96 314.0 In-house 6-277 (284) alignment 
Range on Protein: 47-316
Range on HMM: 6-277/284.0
KELIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPVNM
...  | ..| ..| |. . .| ..|..||||.|||. ||| |.. ||.|  ..|||||||||||   .| | |||||.|. |...|.||||||   .| 
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

QYGFFMECRKRFSN-ALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIA-DLTWADPDATIQMYAESQRGAGRVFGAE
.|||. ||..|. . ..| .|.  |  ||| |.| ..|.|||||.|. | .. ||  ..|| | |.   .| |. |.||    . .    ||   |||..
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

AVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPDLKK
|..|.|.  ...||||||||| |||||||.|.|||||||| ||||.||||||| |...||||| |.||  | 
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkki
subfamily_PPPLV_pd Subfamily PPPLV 49-302 2.7e-55 180.7 In-house 2-278 (290) alignment 
Range on Protein: 49-302
Range on HMM: 2-278/290.0
LIQLCYRAREVFWKNNVKLELKAPVKICGDLHGQYEDLLALlELNGWP-----PETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRP
|. ||  | ... .... ||||.|. . |||||.|.||  . |   |        ...||||||||||.||.|.|. |.| .|| | ||.||||||| . 
llslcdvavdilaaeerllelksptyvlgdlhgnyrdliyf.ekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnheles

VNMQYGFFMECRKRFSNAL---YDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQL-------DKVERPCDVPDigVIADLTWADPDATIQ-----
|  .. .  |.  .| . |   ..||. .|  .|| ||. .|..|.|.|| .      ..       .... . |     .  |. |.||.   .     
vqesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgap..laldilwsdpaedrdlslrg

-------MYAESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVmTVDEE
       .  ...|| | ||...|...||.   |. |.|||.|   |...  . .|.|.||.  |||. ..|| .  ||..
elvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaali.lvdkk
subfamily_PPP7C_pd Subfamily PPP7C 54-205 3.7e-39 127.5 In-house 43-201 (383) alignment 
Range on Protein: 54-205
Range on HMM: 43-201/383.0
YRAREVFWK----NNVKLELKAPVKICGDLHGQYEDLLALLELNGWPP-ETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPVNMQY
. |..|. .    ..|.  .   | .||||||. .||| .|  || |  |  |.| ||.||||  |.|.. .|.|. ...| .|.| |||||   .|..|
reakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlry

GFFMECRKRF---SNALYDAFQLAFYCMPLCAVVSDKIICMHGGISeDLVDLRQLDKVER
||  |  ...   .. .   ..  |  .||.... .||. .||||| |  ||  |||.||
GfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkier
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 67-313 2e-69 227.2 In-house 3-256 (263) alignment 
Range on Protein: 67-313
Range on HMM: 3-256/263.0
LELKAPVKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPVNMQYGFFMECRKRFS-----NA
|||.||..|||| ||||.||| ...  |   .|.||||||||||| .|.||| |||. ..  | |..||||||| . .| .|||. | .|||      ..
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

LYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIG-VIADLTWADPDATIQMYAE-SQRGAGRVFGAEAVKKFLNTHHLELVV
.|. |.  |  |||||.|| .|.|||||||  |  | ..  .  | .      . .|| ||||.   . .     |    ||| . |  . .   ..|.|
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidliv

RAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSFTVMRPD
||||||  || |||||.|.|.|||  |  .. | |||. |.. |  ||  ..|.
rahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpe
Metallophos Calcineurin-like phosphoesterase 72-265 1.9e-40 132.3 Pfam-A 2-199 (200) alignment 
Range on Protein: 72-265
Range on HMM: 2-199/200.0
PVKICGDLHGQYEDL----LALLELNGWPPETKYLFLGDYVDRGPFSIEVISLL--FAYQVLHPDKVFLLRGNHESRPVNMQYGFFMECR----------
.. ..|||||...||    |.||.... .. . .|||||.||||. |.|.. ||  .....| |..||||||||||.|.|  |||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------KRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQLdkverpcdvpdigviadltwadpdatiqmya
                        ..  .  .....  |...||.| |  ||...||..|...    .                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

esqrgAGRVFGAEAVKKFLNTHHLELVVRAHQVV
     ..  || .|. |.|. . . ||.|.|. .
.....gselfgpdalekllekygvdlvlrGHtHk
PPP_2 73-264 9e-68 220.9 In-house 1-197 (198) alignment 
Range on Protein: 73-264
Range on HMM: 1-197/198.0
VKICGDLHGQYEDLLALLELNGWPPETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPVNMQYGFFMECR-KRFSNALYDAFQLAFY
|..|||||||..||| | .  . .||.|||||||||||| .|.||. ||.|... .|..|.||||||||. ||  |||  |.  |. ....|...|  | 
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVPDIGVIADLT----WADPDATIQMYAESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQV
..||.|....|....|||.||..  |.|  | ||....|. | . ||.    . ||... ...|.|.|||| .||.......|....|.|..|||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 73-264 3.2e-64 209.6 In-house 1-196 (197) alignment 
Range on Protein: 73-264
Range on HMM: 1-196/197.0
VKICGDLHGQYEDL-LALLELNGWPP-ETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPVNMQYGFFMECRKRFSNALYDAFQLAF
| ..||.|||..|| | ||.. | |. |..|.|||||||||..|.||. ||.|...  |..|.||||||||. .|  |||  |. .. .. .....|  |
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

YCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVP-DIGVIADLT-WADPDATIQMYAESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQV
 ..||.|....|....|||.|..| .| .....||....| . ... ||  |.||  . ...|.|.|||| .||.....|||....|.|..|.|..
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 73-265 1.2e-60 197.9 In-house 1-199 (199) alignment 
Range on Protein: 73-265
Range on HMM: 1-199/199.0
VKICGDLHGQYEDLLALLELNG-WPP-ETKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPVNMQYGFFMECRKR-FSNALYDAFQLA
| .|||||||..|||  |. .|  |. |..|.|||||||||..|.||. ||.|.... |..|.|||||||.. .|  |||  |. ..  .. .|....  
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FYCMPLCAVVSDKIICMHGGISEDLVDLRQLDKVERPCDVP-DIGVIADLT-WADPD-ATIQMYAESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQVV
| ..||.|....|....|||.|... .. .|.|.||....| . |. |||. |.||  |. .. ..|.|||| .|| ....|||....|.|..|.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_YNL217W_pd Subfamily YNL217W 75-142 2.1e-10 33.5 In-house 14-77 (235) alignment 
Range on Protein: 75-142
Range on HMM: 14-77/235.0
ICGDLHGQYEDLLALLE--LNGWPPETKYLFLGDYVDRGPFSIEVISLLfayqvlHPDKVFLLRGNHESR
. || || |..|. ||.    |  ..   ...|| ...|| |.||.|..      . |.|  ..||||  
vvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 99-313 5e-133 436.2 In-house 101-315 (317) alignment 
Range on Protein: 99-313
Range on HMM: 101-315/317.0
TKYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPVNMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLR
 ||||||||||||||||||..||||...|.|||||||||||||||||.||||..|..||.|.|||.||||||...||||||..||.||||||||.|.||.
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QLDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMT
||||..||.|.||.||.||||||||||....|.||.||||.||||.|||.||....|.|||||||||.|||||||||.|||||||||||||.||.|||..
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDEELVCSFTVMRPD
||..|..|..|.||.
vdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 100-316 7.8e-87 284.5 In-house 121-337 (339) alignment 
Range on Protein: 100-316
Range on HMM: 121-337/339.0
KYLFLGDYVDRGPFSIEVISLLFAYQVLHPDKVFLLRGNHESRPVNMQYGFFMECRKRFSNALYDAFQLAFYCMPLCAVVSDKIICMHGGISEDLVDLRQ
.||||||||||||||.||. || | .. .||...||||||||| ||  |||. |   |.   ||..||  |  .|.|||. . |.|||||||| |  . |
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

LDKVERPCDVPDIGVIADLTWADPDATIQMYAESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTV
.  ..|| ..||.||..|||||||| | . |  | |||  |||  |.. ||.   |..|.| |||| ||||||  |.|||||||| |||| ||.|||...
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DEELVCSFTVMRPDLKK
|..|  |  |.||. . 
dkklkisinvfrpesrd
subfamily_PPP7C_pd Subfamily PPP7C 215-307 1.7e-20 66.1 In-house 237-329 (383) alignment 
Range on Protein: 215-307
Range on HMM: 237-329/383.0
IADLTWADPDATIQMYAESQRGAGRVFGAEAVKKFLNTHHLELVVRAHQVVMDGYEFFADRQLVTIFSAPSYCGQMDNAAAVMTVDEELVCSF
. |. |.|| |.    ... ||.|  ||..  ||.|. ..|.|..|.|.  ..||||  |....|||||  |  .  |  | . . ..|   .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri