Gene F23B12.1 in Caenorhabditis elegans

Synonym: CELE_F23B12.1, CELE_F23B12.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP067_AA protein Get Run
CeleP067_AA_24-318 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 25-318 7.7e-106 347.5 In-house 25-324 (473) alignment 
Range on Protein: 25-318
Range on HMM: 25-324/473.0
KVQNWLHSVIERLkwwspgRCQQLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVIT
. . .|. .||.|      . ..|. |..|..|...|.| ..| .  |...... ..||||||..||..|.|..|.|.| ...||||.|||||.|.||. 
lglldldlliehl......kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevle

LLFTFQILMPDKVFLLRGNHESRPVNMQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLT
||. ..|. |..|||||||||.| .|  |||. |. ..|.. ||..|.  ....||.||. .||...|||.| ||  | |...|.||..||| |.. || 
lllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldll

WADPdEKVFG--------YADSPRGAGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQ------LVTVFSAPSYCGQFDNAAAVMNVDDKLlC
|.|| . ..|        .  ||||||  |||.||..||. ..|||.||.|..|..|||.. |..      ..|||||| |||...| |||. .|..| .
wsdP.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.i

TFTIFRPD
.|..|.|.
sfiqfdps
0049330 Metallo-dependent phosphatases 39-317 3.2e-101 331.4 In-house 20-298 (309) alignment 
Range on Protein: 39-317
Range on HMM: 20-298/309.0
WWSPGRCQQLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVF
...  ....|. |.||..|...|.| ... .  |...... ..||||||..||..|.|..|.| |....||||.|||||.|.||..||. ...|.||.||
lielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvf

LLRGNHESRPVNMQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADS
|||||||.| .|. |||. |.. .|.. |...|.  ....||.||. .||.|.|||.| ||  | |.....||..||. |.. ||.|.||.. . |.|..
llrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapn

PRGAGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRP
|||.|  ||..||..||. ..|||..|.|..|..||..|.|..|.|||||| |||...|..||. .|..|...|..|.|
prglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfep
0053225 Metallo-dependent phosphatases 41-318 6.7e-94 307.5 In-house 14-291 (293) alignment 
Range on Protein: 41-318
Range on HMM: 14-291/293.0
SPGRCQQLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLL
.  ....|. |.||..|.. |.| ..| .  |...... ..|||||...||.||.|. |.|.| ...||||.|||||.|.||..||. ...| ||.|.||
elllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvll

RGNHESRPVNMQYGFYLECKKRY-SVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDeKVFGYADSP
|||||.. .|. |||. |.. .| . .|.|...  ....||.|.. .||...|||.| ||. | |...|.||..||. |.. || | |||  ..|.. |.
rGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsy

RGAGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPD
||.|  ||..||..||. ..|||..|.||||.|||... |..||||||||.|.|...|..||. .|..|...|..|.| 
rglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 41-102 1.2e-31 103.0 In-house 1-62 (317) alignment 
Range on Protein: 41-102
Range on HMM: 1-62/317.0
SPGRCQQLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPE
||..||.||.|.|||||||||||.|||...||..||||.|.||||||||||.||..||||| 
spkkcqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 42-319 1.2e-172 565.8 In-house 1-284 (284) alignment 
Range on Protein: 42-319
Range on HMM: 1-284/284.0
PGRCQQLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWP------EEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPD
|..||.|. |.|||||||||||.|||.|.||.|||||||.||||||||||.||..|||||      .|.|||||||||||||||||||||||....|.||
pvncqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpd

KVFLLRGNHESRPVNMQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGY
|||||||||||||||||||||||||||||.|||.|||||||.||||||||||||||||||||||.||.||.|..||.||||||||.|||||||...|.||
kvfllrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegy

ADSPRGAGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPDL
..||||||..||..|||.||....|||||||||||||||||||||.|||.|||||||||.||.|||.|||..|...||...|||
kesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkpdl
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 44-319 2.7e-105 344.9 In-house 19-295 (299) alignment 
Range on Protein: 44-319
Range on HMM: 19-295/299.0
RCQQLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGN
|  .   |.||..||  |.. | .. . |..|||...|||||||. ||. .|. .|.| . ..||||||||||   .|.||||. |.| .|.. |.||||
rltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgn

HESRPVNMQYGFYLECKKRY-SVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGA
||   .|  |||| ||.||| |  |. .|| ||. |||. ... .|.|||||.|  | .| || .. || | |.  .  || |||||. | ..    || 
hecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgv

GRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPDL
   ||.. |.. ..  ..||| |||||| |||||||...|||.|||| |||||||.||.|.||..|.|||....|  
syvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp
subfamily_PPP2C_pd Subfamily PPP2C 44-319 1.1e-86 283.7 In-house 13-287 (290) alignment 
Range on Protein: 44-319
Range on HMM: 13-287/290.0
RCQQLfVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGN
.|.||  |.|. ||| .|.| . |..   ....|| .|||.|||| ||. || . |   . .||||||||||| .|.| .||| .... ..... .||||
eckql.eesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgn

HESRPVNMQYGFYLECKKRYSV-ALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVfGYADSPRGA
|||| .   |||| || ..|.  ...  |   |...||.|.| ..| |.|||.|  .  | .....||  ..|. | ..|| |.|||..  |.. |||||
hesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg.gwgisprga

GRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPDL
| .|| .  .|| .  .| |..||||.||.||..  ||..||.|||| || .  | ||....||||  .|  | |  
gytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_PPP6C_pd Subfamily PPP6C 44-316 3.6e-81 265.5 In-house 11-282 (290) alignment 
Range on Protein: 44-316
Range on HMM: 11-282/290.0
RCQqLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGN
.|.  . ||.| .|| .  . . ..     ...|| .|||||||| ||. ||   |   . .|.||||.|||| .|.| .|.|.|...  ||.. |||||
kck.ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgn

HESRPVNMQYGFYLECKKRYSVA-LYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPdEKVFGYADSPRGA
|||| .   |||| ||...|  |  .  .   |. ....|.. ....|.|||.| |.  | |.. |.|  .||  | ..|| |.|| |.|  .| |||||
hesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprga

GRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFR
|  || . .|.|... ||.|..||||.|..|.... | .||||.||| || .  | |......|.   .. .|.
gylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 44-102 1.7e-18 59.9 In-house 6-64 (339) alignment 
Range on Protein: 44-102
Range on HMM: 6-64/339.0
RCQQLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPE
 . .||.  || |||.||||  | . . | .|||. . |||||||.||.|....|||| 
tsldlfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 45-310 2.4e-67 220.3 In-house 3-293 (302) alignment 
Range on Protein: 45-310
Range on HMM: 3-293/302.0
CQQLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEE-----------HKYLFLGDYVDRGPFSIEVITLLFTFQILM
 .. . ..||. |.    |.. |.|   .| .|| | ||||||||||. ..  .   ||           .|..|||||||||. ||| |.|.|....| 
rkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvly

PDKVFLLRGNHESRPVNMQYGFYLECKKRYSV----ALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPF-DIPDIGVISDLTWADP
| .  |||||||.. .|. |||  | ..|..      ... |. .|  ||| |.| .||.|.|||||. |  | ...||.||. .. .  .  || .|||
ptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadp

DE--KVFGYADSP-------RGAGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLC
 .  ..   .. |       ||   .|   ||... .  ||.|.|||||..  |. ||||..|.|.|||| |  . ||  ||..|| .   
ldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 46-319 1.2e-119 391.8 In-house 21-295 (298) alignment 
Range on Protein: 46-319
Range on HMM: 21-295/298.0
QQLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHE
 .   |... .|.  |.. | |.|. ....||.|.|||||||. ||. ||. .|.|... ||||||||||| ...|||.||.....  |...||||||||
tkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhe

SRPVNMQYGFYLECKKRY-SVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGR
   .| .|||| |||.|| |..|| .|| .|| .||.|.....|.|||||.|. |  |.|| .. |||| ..  .  || ||||...| |.|.. ||.. 
ceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGvsv

SFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPDL
 || ..||..|.  ..|||||||||| |||||||...|||.|||| |||||||.||||.||.|| ..|....|  
vfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 46-318 3.3e-73 239.2 In-house 13-289 (290) alignment 
Range on Protein: 46-318
Range on HMM: 13-289/290.0
QQLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHE
 . | .....|.  ...| .    . |..|||. | ||||||...|.  |.  | | . |.||||||||||. |.||  ||| ..|... || |||||||
ldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

SRPVNMQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFD--IPDIGVISDLTWADPDE-KVFGYA-DSPRG
 | ||  |||. |  .. .  |.  .|  |. ..||| |..||.|||||||...     |. . .|      | |.. || ||||.. |   .| .  |.
vrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqra

AGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPD
    || ... ..|.   |.|.||||.|  .|..|  |..|||||||| |.|.  |  |...| . |  ......| 
isvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 46-312 1.5e-67 220.9 In-house 3-294 (302) alignment 
Range on Protein: 46-312
Range on HMM: 3-294/302.0
QQLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEE-----------HKYLFLGDYVDRGPFSIEVITLLFTFQILMP
.. . ..||. |.    |.. |.|   .| .|| | ||||||||||. ..  .   ||           .|..|||||||||. ||| |.|.|....| |
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyp

DKVFLLRGNHESRPVNMQYGFYLECKKRYSV----ALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPF-DIPDIGVISDLTWADPD
 .  |||||||.. .|. |||  | ..|..      ... |. .|  ||| |.| .||.|.|||||. |  | ...||.||. .. .  .  || .||| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

E--KVFGYADSP-------RGAGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTF
.  ..   .. |       ||   .|   ||... .  ||.|.|||||..  |. ||||..|.|.|||| |  . ||  ||..|| .   . 
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_PPP4C_pd Subfamily PPP4C 47-316 5.2e-89 291.3 In-house 14-283 (288) alignment 
Range on Protein: 47-316
Range on HMM: 14-283/288.0
QLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHES
.|  |.|. .|| .||| . ..     ...|| .||||||||.||. ||...|  .|..||||||.|||| .|.| . || ....  ||.. |.||||||
elikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhes

RPVNMQYGFYLECKKRY-SVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVfGYADSPRGAGRS
| .   |||| || ..| |....      |. ..|.|.. .||.|.|||.| ..  | ..  |||  ..|. |...|| |.||...  |.| ||||||  
rqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagyl

FGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFR
|| ..|..| .  ...|..||||.||.|| .  .....||.||| || .  | ||....|..|   |.|| 
fgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkife
subfamily_PPG1_pd Subfamily PPG1 47-316 1.3e-73 240.9 In-house 12-294 (300) alignment 
Range on Protein: 47-316
Range on HMM: 12-294/300.0
QLFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHES
.|. |  . ||... .| . |.    .|..|| . ||.|||| |.. .|.. |   . .||||||||||| .|.| |.|| ....  | .. ||||||||
ellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhes

RPVNMQYGFYLECKKRY--SVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEK---------VFG-
| .   |||| || ..|     ... .   |. . |.|.. ..| |.|||.| .   . |.  .||  ..|. | ..|| |.||.|.           | 
rqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregq

-YADSPRGAGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFR
 .  |.|||| |.| . |.|||.. ... ..||||....||. . | .| ||.||| || .  | |..... .|.   | .. 
hfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvye
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 48-317 8.1e-97 317.1 In-house 22-294 (297) alignment 
Range on Protein: 48-317
Range on HMM: 22-294/297.0
LFVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESR
.  |. ...|   | . | ..|  ....||.|.|||||||| ||. ||   |||   .||||||||||| |||| | ||..... .| ..||||||||  
viteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhece

PVNMQYGFYLECKKRY-SVALYDAFQLAFNCMPLCAVVSKKIICMHGGISE---DLIDLTQLEKIDRPFDIPDiGVISDLTWADPDEKVFGYADSPRGAG
 ||  |||| ||.||| || .| |||  || .||. ....||.|||||.|    . . |  | ||.|. .  . ....|| ||||   . |. .  ||||
fvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadllwadpisglsgfmenqrgag

RSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRP
  || .|| |     .||||.|||||| ||||||| |.|||.|||| |||||||.||.| .|.|| |.| |.||
cgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrp
subfamily_PPP1C_pd Subfamily PPP1C 49-318 6.3e-119 389.3 In-house 10-279 (282) alignment 
Range on Protein: 49-318
Range on HMM: 10-279/282.0
FVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRP
. |.|. .|. .||| . .. . |..||||||.||||||..||. ||| .| |.|..||||||||||| .|.|.|.||....|  |...|||||||||  
lkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesas

VNMQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGRSFGP
.|. |||| |||.|||. |. .|. .|||.||.|.|..||.|.|||.|..| .| |..|| || ..|. |.. || |.|||..| |.... ||   .||.
inriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfgk

NAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPD
..|.|||| ..|||.||||||| |||||||.|||||||||| |||.||||.||..||..||..|.|..| 
dvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa
PPP_3 49-315 1.6e-99 325.3 In-house 2-269 (271) alignment 
Range on Protein: 49-315
Range on HMM: 2-269/271.0
FVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRP
..|||| ||. ...| . |... ..|.|||..|||||||..||. ||.  | ..|.|||||||||||| .|.||..||....|..|..|.||||||||| 
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

VNMQYGFYLECK-KRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGRSFG
.|  |||. |.. |...  .|...|  |...||.|....|....|||.|...  | |..|..|. ..|. | . ||.. ...||  |.. |.||||  ||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

PNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIF
|.....||. ..|.|..|||.....|||...|...||||||| ||....||.|.......| ..|...
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 49-317 3.3e-92 301.7 In-house 8-276 (281) alignment 
Range on Protein: 49-317
Range on HMM: 8-276/281.0
FVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRP
. ..|.... . ..  | ..|   .|..|... ||.|.||.|| .|||| | . |....|||||||||| |.||. ||||..|  .|...|||||||   
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

VNMQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGRSFGP
|| .|||| ||. .| . |.  ||  || .|. | ..|.. |||||.| .|. | .| .. .| . .| |.. || |||||.||...  | ||..  || 
vnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGk

NAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRP
| |..  .  ...|..||||||.|||| .. |.|.||||.| || .. |||||. ||..|  ..  . |
nvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 49-318 4.6e-87 284.6 In-house 10-282 (287) alignment 
Range on Protein: 49-318
Range on HMM: 10-282/287.0
FVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRP
| .....|.  ...| .   .. |..|||..|.||||||..||. .|.  | . . .|||||||||||. |.||. |||...|..| || ||||||| . 
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

VNMQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDI--GVISDLTWADPDEKVFGYA-DSPRGAGRS
.| .|||. | |....  ||  |.  |. .|||| |||.|.|||||||..|  | .|. . .|    .   |.. || ||||...  ... .  |.    
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

FGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPD
|| . | ..|.  ..||.||||.|. .||.|..|..|||||||| |.|.  | .||. |.. |  .|. ..|.
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 49-318 3.6e-72 236.1 In-house 20-292 (307) alignment 
Range on Protein: 49-318
Range on HMM: 20-292/307.0
FVENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRP
.  .|. .. | |.  |  .|  .||. |. . ||.||||.||. .| | | | |  |.| ||||||| .|.|.| ||||..| .|... |||||||   
ytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiar

VNMQYGFYLECKKR---YSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGRS
|| .|||| ||          ..  || .|| .|. |... ||.|||||.|  |  | .| .  .|   |  |.. |. |||||  || .  | ||.| .
vnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgft

FGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPD
|| | .    .   ..|..||||...|||  .. |.|.|.|||| ||  . || .|..||. |      | |.
fgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpe
PPP_1 50-304 2e-93 305.5 In-house 2-264 (264) alignment 
Range on Protein: 50-304
Range on HMM: 2-264/264.0
VENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPV
.|.||.||. ...| . |... |........||||||||.||. ||.  | ..|..||||||||||| .|.|...||.....  |...|||||||||| |
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NMQYGFYLECK-KRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLT-------WADPDEKVFGYADSPRG
.  |||. |.. |.||  .|.... .|...||.|.. .||...|||.|..|  | | .|..|  ..|. | ..||.       . |..|.  . |.|.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNV
||  ||.....|||| .||.|..|||.|...||||...|..||.|||. |. ...|..|....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
subfamily_PPZ_pd Subfamily PPZ 50-317 9.9e-91 297.3 In-house 26-293 (300) alignment 
Range on Protein: 50-317
Range on HMM: 26-293/300.0
VENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPV
 ..|....|..||| |  .   |..  .||| ||.|||. ||. ||   |.|   .|||||||||||  |.| | ||. ..|  |...||||||||   |
knseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanv

NMQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGRSFGPN
   |||| |||.|  . .. .|  .|| .||.|.|. ||.|.|||.|  |  . .. .. || |.||.|.| || |.|| .    . |  ||    .   
trvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkv

AVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRP
|..|||.   .|||.||| || |||||| || |||||||| |||.|||  |||.| . |||.| .. |
ainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
PP2Ac_SM00156 51-317 1.7e-108 354.7 In-house 3-269 (271) alignment 
Range on Protein: 51-317
Range on HMM: 3-269/271.0
ENELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVN
..|..||. ...| . ..|. ....||| ..||||||..||. |.||.| |.|.||.||||||||||.|||||.|||...|| |.||.||||||||..||
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

MQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGRSFGPNA
. |||. |.| .|.  .|. |. ||...||.|.|..||.|||||.|..|  | ...|..|. ..|. |.. ||.|.||..|. |.. | ||..  ||..|
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgeda

VKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRP
||.||. .||.|..|||.||..|||||||..|||.|||| ||..|.|.|||..|...| ...  ...
vkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_PPP3C_pd Subfamily PPP3C 52-307 1.9e-78 257.3 In-house 44-312 (452) alignment 
Range on Protein: 52-307
Range on HMM: 44-312/452.0
NELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNM
.. ...  .| . . |.|  |..|||. ..||||||| ||. |||..| |.. |||||||||||| ||||..  |.. .|  |...||||||||.| .  
eaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlte

QYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFG-------YADSPRGAGR
 . |  |||..|| ..|||.  .|...|| |.. .. .|.|||.| .. .| ...|.||  ..|  | . || |.|| |.            .|.||   
yftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsy

SFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFAD------RQLVTVFSAPSYCGQFDNAAAVMNVDDK
 .. .|| .|||  .|  ..|||..  .||. . .        |.|.|||| |.. ..| |||......
fysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 53-321 7e-96 314.0 In-house 7-277 (284) alignment 
Range on Protein: 53-321
Range on HMM: 7-277/284.0
ELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNMQ
..  | ..| . | |. . .....|..||||||||| ||. ||. ||.|   .|||||||||||   .| | |||......|...|.||||||   .| .
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYLECKKRYS-VALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVI-SDLTWADPDEKVFGYADSPRGAGRSFGPNA
|||| ||..||   ..| .|.  |  ||| |.| ..|.|||||.|. | ...||  | |||| |.   .  |. |.|| .   |.    ||    || .|
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

VKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPDLKV
..|.|.  ..|||||||||| |||||||.|.|||.|||| |||||||||||| |. .|.|.| ..||  |.
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkki
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 53-315 4.4e-81 265.4 In-house 10-272 (280) alignment 
Range on Protein: 53-315
Range on HMM: 10-272/280.0
ELIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNMQ
|.| .       | ..    . |||.|. |||| |..|.  ||.| |   | | .||||||||||  |||. ||| ..|   |...|||||||.  ||  
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

YGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGRSFGPNAVK
||||.||. .| |.|.  || .|| ||.....||...|||||.| .||.|  . .| || .  | |.. || |.|| .|  |.  | ||    ||   |.
ygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvve

KFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIF
.  .  ..||..|||||| ||||..| |.|.|||| | || || |||||. .. .|  .|  .
qacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqql
subfamily_PPPLV_pd Subfamily PPPLV 54-312 3.6e-56 183.6 In-house 2-283 (290) alignment 
Range on Protein: 54-312
Range on HMM: 2-283/290.0
LIELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMaLFELNGWPE-----EHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRP
|. ||  | ... .... |....|. . ||.||...||.  ||   |         ..||||||||||.||.|.|. |.. ..|.| ||.||||||| . 
llslcdvavdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnheles

VNMQYGFYLECKKRYSVAL---YDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDR-----PFDIPDIGVISDLTWADPDEK---------
|  .. .. |.. ..   |   ..||. .|. .|| ||. .|..|.|.|| .     ...  |.      . ||    .  |. |.||.|.         
vqesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgel

--VFGYAD-SPRGAGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNaAAVMNVDDKLLCTF
    |..| . || |  |. .|...||.  ||. |.|||.|   |...  . .|.||||.  |||. .. ||.. || | | . 
vlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssne.aalilvdkkklrii
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 56-320 2.7e-104 341.2 In-house 13-277 (280) alignment 
Range on Protein: 56-320
Range on HMM: 13-277/280.0
ELCYRAREQFWKNKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNMQYGF
..  . .. .  ..  ....|||..|||.|||. ||. ||.  ..| ...||||||||||| . .||| ||.....  |.. ..||||||   .| .|||
rviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygf

YLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGRSFGPNAVKKFL
. |.|.||| |||. ||  .. .||.|.|| .|.|||||.|..|. |..| .. |||| .|  .  || ||||..|| |.|...||.   || | ||.. 
kdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdlt

QMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPDLK
.. ..||..| |||| ||||||||..|||||||| |.|.|||.|||. ||..|  .| ...|.|.
ekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalr
subfamily_PPP7C_pd Subfamily PPP7C 68-210 1e-40 132.7 In-house 56-201 (383) alignment 
Range on Protein: 68-210
Range on HMM: 56-201/383.0
NKVKLDIEAPVKICGDIHGQFEDLMALFELNGWPE-EHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNMQYGFYLECKKRY---
..|.  |   | .|||.||...||. ..  || |  |. |.| ||.||||  |.|.. .|... ...| .|.| |||||   .|..|||  | ...|   
srvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvh

SVALYDAFQLAFNCMPLCAVVSKKIICMHGGISeDLIDLTQLEKIDR
.  .   ..  |  .||.... .||. .||||| |  ||. |.||.|
gkkilrlledvfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP5C_pd Subfamily PPP5C 69-315 3.5e-82 269.0 In-house 58-306 (322) alignment 
Range on Protein: 69-315
Range on HMM: 58-306/322.0
KVKLDIEAPVKICGDIHGQFEDLMALFELNGWP-EEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNMQYGFYLECKKRYSVAL
..... .  . .|||||||| ||. .||||| | ||. ||| ||.|||| ||.||| .|..|..| |...|| ||||||  .|  |||  |.|..|. ..
eitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekv

YDAFQLAFNCMPLCAVVSKKIICMHGGI-SEDLIDLTQLEKIDRPFDIPDIGVISDLTWADPDEKvFGYADSPRGAGRSFGPNAVKKFLQMHNLDLVVRA
.| |.  || .||. |. .|.. .|||. ||| . | .| ||||  . |. |.. .| |.||.|.  | . | || |  |||.  ||||.  ||.|..|.
adlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea.nGrspskrGvgvqfGpdvtkkflkennleliirs

HQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNV-DDKLLCTFTIF
|.| ..|||.  | .|.|||||| || | .| .|.... .|.|  .|. |
hevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktf
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 72-318 6.9e-70 228.7 In-house 3-256 (263) alignment 
Range on Protein: 72-318
Range on HMM: 3-256/263.0
LDIEAPVKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNMQYGFYLECKKRYSV-----A
|...||..|||| |||..||. .|.  |   . .||||||||||| .|.||| |||.... || |..||||||| . .| .|||. | |||.       .
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

LYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDI-GVISDLTWADPDEKVFGYAD-SPRGAGRSFGPNAVKKFLQMHNLDLVV
.|. |.  |. |||||.|||.|.|||||||  |  | ..  |  |..      .  || ||||..   |.     |     || . |  . .  ..||.|
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidliv

RAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFTIFRPD
||||||  || |||||.|.|||||  |  .. | |||. |.  |  .|  ..|.
rahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpe
Metallophos Calcineurin-like phosphoesterase 77-270 6.5e-43 140.3 Pfam-A 2-199 (200) alignment 
Range on Protein: 77-270
Range on HMM: 2-199/200.0
PVKICGDIHGQFEDL----MALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLL--FTFQILMPDKVFLLRGNHESRPVNMQYGFYLECK----------
.. ..||.||...||    ..|..... ..   .|||||.||||. |.|.. ||  .  ..|.|..||||||||||.|.|  |||.||.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------KRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLTQLekidrpfdipdigvisdltwadpdekvfgya
                        ...    .....  |...||.| | .||...||..|...   ..                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

dsprgAGRSFGPNAVKKFLQMHNLDLVVRAHQVV
     ..  |||.|. |.|. ...|||.|.|. .
.....gselfgpdalekllekygvdlvlrGHtHk
PPP_2 78-269 4.5e-70 228.4 In-house 1-197 (198) alignment 
Range on Protein: 78-269
Range on HMM: 1-197/198.0
VKICGDIHGQFEDLMALFELNGWPEEHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNMQYGFYLECK-KRYSVALYDAFQLAFN
|..|||.|||..||. ||.  . ..|.|||||||||||| .|.||..||..... .|..|.||||||||. ||  |||. |.. |... ..|...|  |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIPDIGVISDLT----WADPDEKVFGYADSPRGAGRSFGPNAVKKFLQMHNLDLVVRAHQV
..||.|....|....|||.||..  |.| .|..|. ..|. | . ||.    . ||.||  ..| | ||||  |||......|. ..|.|..|||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 78-269 2.5e-67 219.7 In-house 1-196 (197) alignment 
Range on Protein: 78-269
Range on HMM: 1-196/197.0
VKICGDIHGQFEDL-MALFELNGWPE-EHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNMQYGFYLECKKRYSVALYDAFQLAF
| ..||||||..|| . |... | |. |..|.|||||||||..|.||..||. ... .|..|.||||||||. .|  |||. |......  .....|  |
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIP-DIGVISDLT-WADPDEKVFGYADSPRGAGRSFGPNAVKKFLQMHNLDLVVRAHQV
...||.|....|....|||.|..| .|...|.|.|....| . ... ||  |.|| |.  |.|.| ||||  |||....|||. .||.|..|.|..
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 78-270 4.3e-63 205.9 In-house 1-199 (199) alignment 
Range on Protein: 78-270
Range on HMM: 1-199/199.0
VKICGDIHGQFEDL-MALFElNG-WPE-EHKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNMQYGFYLECKKR-YSVALYDAFQL
| .|||.|||..|| . ||. .|  |. |..|.|||||||||..|.||..||. .....|..|.|||||||.. .|  |||. |.... ..  .|.... 
vtvcGDlHGqlddlllilfk.eggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsd

AFNCMPLCAVVSKKIICMHGGISEDLIDLTQLEKIDRPFDIP-DIGVISDLT-WADPDEKVFG-YADSPRGAGRSFGPNAVKKFLQMHNLDLVVRAHQVV
 |...||.|....|....|||.|... ....||||.|...|| . |. .||. |.|| ... |  . | ||||  |||....|||. .||.|..|.|...
vfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_YNL217W_pd Subfamily YNL217W 80-147 1.2e-07 24.5 In-house 14-77 (235) alignment 
Range on Protein: 80-147
Range on HMM: 14-77/235.0
ICGDIHGQFEDLMALFE--LNGWPEEHKYLFLGDYVDRGPFSIEVITLLftfqilMPDKVFLLRGNHESR
. ||.|| ...|. |..    |  |.   ...|| ...|| |.||. ..        |.|  ..||||  
vvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 104-318 1.7e-132 434.4 In-house 101-315 (317) alignment 
Range on Protein: 104-318
Range on HMM: 101-315/317.0
HKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNMQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLT
.||||||||||||||||||..|||....|.|||||||||||||||||.||||| |.|||||.|||.|||||||..||||||.|||.||||||||.|.||.
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMN
||.|..||.||||.||..||||||||..| ||..|.||||..||..|||.||....|||||||||||.|||||||||.|||.|||||||||.||.|||..
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDDKLLCTFTIFRPD
||.|| ......||.
vdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 104-318 1.8e-88 289.9 In-house 120-334 (339) alignment 
Range on Protein: 104-318
Range on HMM: 120-334/339.0
HKYLFLGDYVDRGPFSIEVITLLFTFQILMPDKVFLLRGNHESRPVNMQYGFYLECKKRYSVALYDAFQLAFNCMPLCAVVSKKIICMHGGISEDLIDLT
..||||||||||||||.||. || ....  ||...||||||||| ||  |||| | . ||   ||..||  || .|.|||. . |.|||||||| |  . 
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QLEKIDRPFDIPDIGVISDLTWADPDEKVFGYADSPRGAGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMN
|.  . ||..|||.||..||||||||    ||  | |||   ||| |.. ||.  .|..|.| |||| ||||||  |.|||.|||| |||| ||.|||. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

VDDKLLCTFTIFRPD
.| ||  .  .|||.
idkklkisinvfrpe
subfamily_PPP7C_pd Subfamily PPP7C 220-313 5.8e-20 64.3 In-house 237-330 (383) alignment 
Range on Protein: 220-313
Range on HMM: 237-330/383.0
ISDLTWADPDEKVFGYADSPRGAGRSFGPNAVKKFLQMHNLDLVVRAHQVVMDGYEFFADRQLVTVFSAPSYCGQFDNAAAVMNVDDKLLCTFT
. |. |.|| .|    ... ||.|  |||.  ||.|| .||.|..|.|.  ..||||  |....|.|||  |  .  |  | ... ..|   . 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpriv