Gene F25B3.4 in Caenorhabditis elegans

Synonym: CELE_F25B3.4, F25B3.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP068_AA protein Get Run
CeleP068_AA_75-359 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 59-350 5.7e-108 353.7 In-house 4-295 (297) alignment 
Range on Protein: 59-350
Range on HMM: 4-295/297.0
SILMRVLeSGKSTDMELTRLIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFA
||.. || |  . .  |...|  | |  ||  |...|..|  ..|||.||..|||||||| |||||| . |.|  |||||||||||||.  .|||.||.|
siiidvl.sasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivllla

YKVIFPNHFFMLRGNHECSLINRQYGFYEECQRRYNKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQ---NVSQLRAIKRPFDNPEpnTLAIDI
||| ||  .|.||||||| ..|. ||||||||.||.   .. .|| ||  .||| |. ..|||||||.| .|     .  || |.|. .  |  .|  |.
ykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke..rlvadl

LWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
||.||     |.  | ||    || ||. ||   ...|||.|||||||||||||| |.|||||||| |||||||.||.| ....| ||| .||| 
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 60-353 1.5e-158 519.5 In-house 6-297 (298) alignment 
Range on Protein: 60-353
Range on HMM: 6-297/298.0
ILMRVLESGKsTDMELTRLIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAY
.|..||. .. .. .||. |  ||||.|. .| .||.||..|.||..||..|||||||.|||||||||.|||..|||||||||||||...||.|.||.||
llievlsvsl.sekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllay

KVIFPNHFFMLRGNHECSLINRQYGFYEECQRRYNKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPnTLAIDILWSD
|| .||.||.|||||||..|||.|||||||.|||.. .....||.||...|||||.|.||||||||.||.|....|||..|||||..|. .||||.||.|
kvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskee.slaidllwad

PTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKKI
|.|..|||..||||||.|||.|....||..|.|||||||||||||||||||...||||||||.|||||||.||||.|...||.||.||.|.||.
penavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 60-354 8.5e-131 428.6 In-house 6-298 (299) alignment 
Range on Protein: 60-354
Range on HMM: 6-298/299.0
ILMRVLESGKSTdMELTRLIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAY
.|...|. |.|   .||. .  ... ||   | |.| .|. |.||..|| .|||||||.|||||.|||.|||  .|.||||||||||.  ||.| ||...
llskllnvgmse.krltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcf

KVIFPNHFFMLRGNHECSLINRQYGFYEECQRRYNKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPnTLAIDILWSD
|. .|..||||||||||  ||| |||||||..||.   .|  ||  |..|||| |.| ||||||||.|  ||.. ||| . || | |.| .| ||.||.|
kikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnp.slgidllwad

PTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKKIA
| .. |.| .| |||||||| | ... ..||.|||| ||||||||||||||...|||||||| |||||||.||.| |..||||.||||.| .| .
pdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpksl
subfamily_PPZ_pd Subfamily PPZ 63-352 6.5e-101 330.8 In-house 9-296 (300) alignment 
Range on Protein: 63-352
Range on HMM: 9-296/300.0
RVLESGKSTDMELTRLIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVI
..|..| ..       .  ...  . ..|  .|  || |.|.. ...| ||.|||..|||||| | |||  ||||||||||||||..|||||||..||. 
klldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykik

FPNHFFMLRGNHECSLINRQYGFYEECQRRYNKpSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPnTLAIDILWSDPTN
.|. ||.|||||||. . | ||||.||.|| |   .|..|   |  .||.|.|  .|.|.|||.| .|... ..| . || | |.   |  |.||||||.
ypenffllrgnhecanvtrvygfydeckrrcni.kiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdf.glindllwsdptd

FQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKK
 .. |. | |||||..   |. |.|... .|||.||| ||.|||||| .| |||.|||| |||.|||  ||| |.. |.||| .| |   
ssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 75-350 2.5e-117 384.0 In-house 2-275 (280) alignment 
Range on Protein: 75-350
Range on HMM: 2-275/280.0
LTRLIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNH
|.. |   |..... .   |.  |  ..||..|...|||.|||..||||||.. .||   ||||||||||||.. || ||||.|||| .||.|..|||||
llacikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnh

ECSLINRQYGFYEECQRRYNKpSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEpNTLAIDILWSDPTNFQKGWNPNSRGV
|.  |||.|||..|..|||.. ...  || ..  .||.|||. ||||||||.|. |. ...|. ..||||... ..|| |.||.|| | . ||  |||||
evisinrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsed.eclamdllwadpenkvtgwaensrgv

SYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
|..||.. ...| ..|.|||..| ||||||||||||...|||.|||| |.|.|||.|||. |...|. || ||.| 
svifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_PPP4C_pd Subfamily PPP4C 75-347 1.2e-84 277.0 In-house 12-282 (288) alignment 
Range on Protein: 75-347
Range on HMM: 12-282/288.0
LTRLIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNH
 ..||  |.|..|  .|  |. ..  . .|.||. .|||||||| |||.||. .|  .  |||||||.||||.. .||.||| |.|| .|..  ..||||
rcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnh

ECSLINRQYGFYEECQRRYNKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLaIDILWSDPTNFQkGWNPNSRGV
|.  | . ||||.|| |.| . .||.    ||  ..|.|.. ..|.|.|||.|  .... ..|.| |  . |.  .| .|.||||| . . ||.   || 
esrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegpl.cdllwsdpedae.gwavsprga

SYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVL
 |.||||.  .. .. .|.|..||||.|..|| .  |....|..||| || .  | ||.. ....|   | ..
gylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
0045823 Metallo-dependent phosphatases 76-359 2.4e-103 339.2 In-house 40-333 (473) alignment 
Range on Protein: 76-359
Range on HMM: 40-333/473.0
TRLIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHE
  |.|.||.  ||  | .|..|.|.|.|.. .| ..||||||. |||||..|.|||.  ...||||.|||| . ||...||.|.|. .|...|.||||||
egllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHE

CSLINRQYGFYEECQRRYNKPsVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEpNTLAIDILWSDPtNFQKG--------W
. |.|  |||..|. ..|. . ... |. ... .||.|..|..||..|||.|  |....|.|.|.||.. |. . |. |.|||||   ..|        .
lrllnglygfgdetlekyged.lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipd.dgllldllwsdP.weddgdgllrlrff

NPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRR------LVTIFSAPFYCGQFDNAAAVMYVNKNLvCSFVVLRPRKKIARRRMM
 .. ||..|.|| ||....|.. ..||.||.|..|..|||.. ...      ..|.|||| |||...| |||......| .||....| .   .. ..
gnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphplilplf
0049330 Metallo-dependent phosphatases 76-355 1.1e-99 326.4 In-house 27-304 (309) alignment 
Range on Protein: 76-355
Range on HMM: 27-304/309.0
TRLIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHE
. |.. |.. .||..|..|. ..|.|.|.. .| ..||||||. |||||..|.|||   ...||||.|||| . ||..|||.|.|. .|...|.||||||
lkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHE

CSLINRQYGFYEECQRRYNkPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPnTLAIDILWSDPTNFQKGWNPNSRGVS
. |.|. |||..|..|.|. ...|. |. ... .||.|..|..|||.|||.|  |....|.|...||.. |.   |  |.|||||... .|. || ||..
lrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipld.gllcdllwsdplpiregfapnprglg

YVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKKIAR
.||| .|....| ....||..|.|..|..||..|....|.|.|||| |||...|..||......||.||....| . . .
vvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll
0053225 Metallo-dependent phosphatases 76-350 1.6e-91 299.7 In-house 19-291 (293) alignment 
Range on Protein: 76-350
Range on HMM: 19-291/293.0
TRLIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHE
. |.. |.. .||..|..|. |.|.|.|.. .| ..|||||.. |||.|..| |||.  ...||||.|||| . ||...||.|.|. .|.....||||||
lkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHE

CSLINRQYGFYEECQRRYNKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNtLAIDILWSDPTnFQKGWNPNSRGVS
. |.|  |||..|. |.|   ..|. .. ... .||.||.|..||..|||.|  | ...|.| |.||.. |. . |  |.|||||. . .|| |. ||..
lmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplripleg.llldllwsdpd.lwsgwlpsyrglg

YVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
.||| .|....|.. ..||..|.||||.|||... ...|||.|||| |.|...|..||......||..|....|.
vvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_PPG1_pd Subfamily PPG1 76-345 3.6e-65 213.2 In-house 11-291 (300) alignment 
Range on Protein: 76-345
Range on HMM: 11-291/300.0
TRLIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHE
..|.|   |. | ..   .. |.  .||..||. . ||.|||| |.| .|.  |    .|||||||||||| . .||| || . |. .|    .||||||
aellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhe

CSLINRQYGFYEECQRRY-NKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAiDILWSDPT---------NFQK
   | . |||| || |.|  .. ||. .  .|  . |.|.. . | |.|||.|   . . |.. . |  . |.  .|| |.|||||            ..
srqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegala.dllwsdpeennnptldhpdre

G--WNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFV
|  .    ||  | .| |   |.|   ... ..||||....||. . . .| |..||| || .  | |... .....   | 
gqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfn
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 77-360 7.5e-208 681.4 In-house 1-284 (284) alignment 
Range on Protein: 77-360
Range on HMM: 1-284/284.0
RLIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHEC
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
rlippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhec

SLINRQYGFYEECQRRYNKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDILWSDPTNFQKGWNPNSRGVSY
||||..||||||||||||||||..||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
slinkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsy

VFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKKIARRRMMP
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
vfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiarrrmmp
subfamily_PPP7C_pd Subfamily PPP7C 77-241 7.5e-42 136.4 In-house 31-201 (383) alignment 
Range on Protein: 77-241
Range on HMM: 31-201/383.0
RLIPPEDVETLLFHAFSIFNKQPMLIEVN----SPINICGDIHGQFSDLLRLFDKNGFPHRA-NYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLR
.|. .. | ..|. |  .... | . .|.      . .|||.||.. ||| .. |||.|    .|.| ||.|||||. .| .|.|.|. ...|..... |
kllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnr

GNHECSLINRQYGFYEECQRRY--NKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMlQNVSQLRAIKR
|||| ...| .|||  | . .|  ..  . . .. ||. .||..|. ..|| .|||.|..  ... |  |.|
GnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkier
subfamily_PPP6C_pd Subfamily PPP6C 78-340 6.5e-75 244.9 In-house 14-274 (290) alignment 
Range on Protein: 78-340
Range on HMM: 14-274/290.0
LIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECS
 .| .|.. |  .   .. ..  .  |.||. .|||||||| ||. || . |    ..|.||||.|||| . |||. .|.. |. .|..  .||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

LINRQYGFYEECQRRYNKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAiDILWSDPTNFQKgWNPNSRGVSYV
 | . ||||.||...| . ..|. .  || .....|.. ...||.|||.|  .. . |.| |.|  . |.  ... |..|||| . .. |.  .||  |.
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafc.dlvwsdpedvet.wavsprgagyl

FGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNL
|||   ....   ...|..||||.|..|.... . .|||..||| || .  | |... .... 
fgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 78-133 6.6e-14 44.8 In-house 8-63 (317) alignment 
Range on Protein: 78-133
Range on HMM: 8-63/317.0
LIPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHR
|.  ...  | . |  .| |.|. .|...|. |.||||||| ||| |.| ||.|. 
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpls
subfamily_PPP1C_pd Subfamily PPP1C 79-352 1.1e-123 405.0 In-house 10-281 (282) alignment 
Range on Protein: 79-352
Range on HMM: 10-281/282.0
IPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSL
.  ...|.|| .| .|. .||.|.|.. |..|.||||||..||||||...|.| ..|||||||||||||. ||||.||.|||. .|...|.||||||.. 
lkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesas

INRQYGFYEECQRRYNKPsVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPnTLAIDILWSDPTNFQKGWNPNSRGVSYVF
||| ||||.||.|||..  .|..|. ||...||.||| ..|||.|||.|. |....|.| |.|| . ||  .|..|.||||| . ..||. |.||||..|
inriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpek.gllcdllWsdpdkevlgwsendrGvsftf

GSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKK
|.|...|.| . ..||.|||||||.|||||||.|.|||.|||| |||.||||.||. |...|..|| .|.|.||
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_PPP2C_pd Subfamily PPP2C 79-349 4.9e-81 265.1 In-house 17-285 (290) alignment 
Range on Protein: 79-349
Range on HMM: 17-285/290.0
IPPEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSL
.  ..|..|  .|  |..|.  . ||..|. .|||.|||| ||| ||   |    .|||||||||||| . .||. || | || ...   .||||||   
leesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrq

INRQYGFYEECQRRYNKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAiDILWSDPTNfQKGWNPNSRGVSYVF
| . ||||.|| |.| ...||. |  .| ..|||||| ..|.|.|||.| ... . ..||..|  . |.  .|. |.||||| . ..||.   ||  | |
itqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplc.dllwsdpdd.rggwgisprgagytf

GSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRP
| |  .|. .. .. |..||||.| .||..  .|..||||||| || .  | ||.. ....|  ||.   |
gkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
PP2Ac_SM00156 81-350 4.9e-117 382.8 In-house 3-270 (271) alignment 
Range on Protein: 81-350
Range on HMM: 3-270/271.0
PEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLIN
.|.| .|| .. .|......|.||..|. ..||||||..|||||....|.|.. .|.|||||||||....|.||||||.|...|.....||||||.| .|
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

RQYGFYEECQRRYnKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRpFDNPEPNTLAIDILWSDPTNFQKGWNPNSRGVSYVFGS
. |||.||..|.| . .... |. .||..||.|||...|||||||.|..|......| .|| ..... ..|.||.|||||.. .||..|..||.|.|||.
kiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr.vkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
||....|......|..|||.||..||||||...|||||||| ||..|.|.|||. |.||| .|...|.. 
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
PPP_3 81-347 1.3e-98 322.3 In-house 4-269 (271) alignment 
Range on Protein: 81-347
Range on HMM: 4-269/271.0
PEDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLIN
 .....|. .. .|..|...|.|...|...|||||||. |||.||.. |.... .||||||||||||. ||..|||.|.|. .|.....||||||.. ||
enelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqin

RQYGFYEECQRRYNKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEpNTLAIDILWSDPTNFQKGWNPNSRGVSYVFGS
. |||..|....... .|.. .| ||...||.||. ...|..|||.|. .....|.. ..|. . || ... .| |.|.... ..|.....||....||.
kvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpe.egklldlllssdpekeeglenskrGagllFgp

DALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVL
|. ...|.. ...|..|||.....|||.......||.|||| ||....||.|.. ....| ..|..|
dvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 82-349 9e-105 343.2 In-house 11-282 (284) alignment 
Range on Protein: 82-349
Range on HMM: 11-282/284.0
EDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFP------HRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHE
...  | . |  .| |... .|...|..|.||||||| ||| |.| ||.|      .  .||||||||||| . .| |.||||||...|.. |.||||||
kelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhe

CSLINRQYGFYEECQRRYNKpSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNtLAIDILWSDPTNFQKGWNPNSRGVS
   .|.|||||.||..|| . .....||  | .|||.|.|...|.|||||.|. | .. || ...||.| |.   .  |. |.|| .  .|..   ||  
srpvnmqygfyleckkryse.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdig.viadltwadpeaevegykesprgag

YVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRP
 |||..|....|.. ..||||||||||.|||||||.|.||||||||.||||.||.|||. |...||.||.||.|
kvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 82-352 1.7e-101 332.0 In-house 13-284 (287) alignment 
Range on Protein: 82-352
Range on HMM: 13-284/287.0
EDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINR
.|. ..| .. .|..  | |.||..||.|.||||||. ||||.|.. | . . .||||||||||| . || .||||..|. .|..  .||||||.  ||.
kdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkink

QYGFYEECQRRYNkPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEP-NTLAIDILWSDPTNFQKGWNPN-SRGVSYVFG
.|||.|| .|...  .... |. ||| .|| | |..||||||||.|. |. . .|.|.|.|  . .  . | .|.||.||.. .|. ..|  |..| |||
lyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfG

SDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKK
   . .|| .|.|||.||||.|...||.|....||||.||||.|.|.  | .||. |.| |  |||||.| . 
kkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 82-350 1.9e-91 299.2 In-house 11-277 (281) alignment 
Range on Protein: 82-350
Range on HMM: 11-277/281.0
EDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINR
|..|...... .|| ..  |.|...|| . ||.|.|| || |||.  | . .  ..|||||||||...||...|||..|. .... ..|||||| . .|.
eeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnk

QYGFYEECQRRYNKpSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEpNTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSD
.||||.||. .| .  .|  ||  |  .|..||. .|.||||||.|  | .  .|| . .| .|..   | ||.||.||.|  ..|   |||.|..|| .
iygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnld.rGlviDllwadpdnkveewkassrGssftfGkn

ALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
 . .   ||...|..||||||||||| .. |.|.|.||.| || .. |||||. |...|  |.| | | 
vvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 82-351 2.2e-86 282.4 In-house 19-290 (290) alignment 
Range on Protein: 82-351
Range on HMM: 19-290/290.0
EDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINR
.|. ..| .. .|..  | |.||..|| | ||||||. .||| ||. |.| . ..|||||||||| . ||  |||| ||. ....  .||||||.  .||
kdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnr

QYGFYEECQRRYNKpSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEP-NTLAIDILWSDPTN-FQKGWNP-NSRGVSYVF
 |||.||  |. .   .|. .| ||. ..| | ||..|||||||.|. ..    |.|.|.|  . .  . | .|.||.|||.  ..  .    |..| ||
lygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvf

GSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRK
| ..| .|| .| ..|.||||.| ..|..|  ...|||.||||.|.|.  |  |.. | . |  |.|||.|||
gkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkprk
subfamily_PPP3C_pd Subfamily PPP3C 82-340 1.2e-75 248.0 In-house 44-313 (452) alignment 
Range on Protein: 82-340
Range on HMM: 44-313/452.0
EDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINR
|..  .. .| ....|.. |.||..|| ..||||||| |||.||. .| |. ..||||||||||| . .|..| |.| |. .|...|.|||||||  .  
eaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlte

QYGFYEECQRRYNKpSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRpFDNPEPNTLAIDILWSDPT-NFQK-----GWNPNS-RGV
 . | |||. .|.. .|....   | ..||.||. |. ||.|||.|  .... ... ..| | .|.   .  |.|||||. ....      . ||| || 
yftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldr.fkeppasGplcdllWsdPledygeekteekfvpnsvrGc

SYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFAN------RRLVTIFSAPFYCGQFDNAAAVMYVNKNL
||...  |  ..|.. ..  ..|||.. ..||. . .        |.|.|||| |.. ..| |||. ...| 
syfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 82-350 4.9e-71 232.4 In-house 23-292 (307) alignment 
Range on Protein: 82-350
Range on HMM: 23-292/307.0
EDVETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINR
|..| ... | .||  .  |.... |  . ||.|||| ||. .|   | |  . |.| |||||||  .||.|||||.||...|..  .|||||| . .|.
eefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk

QYGFYEECQRRYNKP--SVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEpNTLAIDILWSDPTNFQKGWNPNSRGVSYVFG
.|||||||     |    .|  || .|  .|..||.  .|||||||.|  |  . .||   .|  ||    .  |.||.||      |.  |||  . ||
kygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpf.rgivndmlwadpdpsvfewkassrgsgftfg

SDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
.. .  .  || ..|..||||.. |||  .. |.|.||||||.||  . || .|. |.. |    | . | 
tnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpe
PPP_1 84-335 5.3e-93 304.1 In-house 6-263 (264) alignment 
Range on Protein: 84-335
Range on HMM: 6-263/264.0
VETLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINRQY
. .|. .. ...||...|.||...| .|||||||| |||.|| . |.... |||||||||||||. .|..|||.|.|. .|...|.||||||.. ... |
laelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvy

GFYEECQRRYNKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAI------DILWSDPTNFQKGWNPNSRGVSYV
||..|..... . .... .. || |.||.||. ..||..|||.|..|. . | | ..|  . ||  .|        |||.||... ..... . ||..|.
gFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagyl

FGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMY
||.|. .|.|.. ...|..|||.|...||||...|..||||||. |. ...|..|.. 
fgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_PPP5C_pd Subfamily PPP5C 84-340 2.1e-76 250.0 In-house 39-299 (322) alignment 
Range on Protein: 84-340
Range on HMM: 39-299/322.0
VETLLFHAFSIFNKQPMLIEVNSP----INICGDIHGQFSDLLRLFDKNGFPHRA-NYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSL
. ..| .| ....|.| |.|.. .    . .|||||||| ||| .|..|| | .   ||| ||.|||| . .|.||.|...|...|||||. ||||| . 
alkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdn

INRQYGFYEECQRRYNKpSVWHSFQGVFSVMPLTALVGQRILCMHGGVS-KMLQNVSQLRAIKRPFDNPEPNTLaIDILWSDPTNfQKGWNPNSRGVSYV
.|. ||| .|.. .|..  | . |. ||. .||. .. ...| .|||.  .   ....|| |.|  ..|| ..| ...||||| . ..| .| .|||.  
mnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegll.vellwsdpqe.anGrspskrGvgvq

FGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYV-NKNL
|| |  .|.|.  ...|..|.|.| ..|||.  . .|.|.|||| || | .| .|.. . ...|
fGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddl
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 86-351 2.4e-77 253.1 In-house 13-301 (302) alignment 
Range on Protein: 86-351
Range on HMM: 13-301/302.0
TLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKN----------GFPH-RANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNH
.|. .  . ..|.  |.|. .|. | ||||||| ||.|.. ..           . . .  ..|||||||||.. .| | |.||.||..|... .|||||
llieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnh

ECSLINRQYGFYEECQRRYNKPS---VWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDILWSDPTNFQKGW----
|.  ||  ||| || . |. |     .|. |. ||| |||.||||..|||.|||.|. |. . ... ||||. .  ...|| |.|..||...|.      
etkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavse

----NP-NSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRK
    .  . ||.|.||   |.|..  ||...|.|||||..  |. |||...|.|||||| |  . ||  ||. |. |   |  |||..|
kPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrnkk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 86-350 7.9e-77 251.4 In-house 14-301 (302) alignment 
Range on Protein: 86-350
Range on HMM: 14-301/302.0
TLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKN----------GFPH-RANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNH
.|. .  . ..|.  |.|. .|. | ||||||| ||.|.. ..           . . .  ..|||||||||.. .| | |.||.||..|... .|||||
llieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnh

ECSLINRQYGFYEECQRRYNKPS---VWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDILWSDPTNFQKGW----
|.  ||  ||| || . |. |     .|. |. ||| |||.||||..|||.|||.|. |. . ... ||||. .  ...|| |.|..||...|.      
etkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavse

----NP-NSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
    .  . ||.|.||   |.|..  ||...|.|||||..  |. |||...|.|||||| |  . ||  ||. |. |   |  |||..
kPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrnk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 86-132 5.4e-09 28.6 In-house 18-64 (339) alignment 
Range on Protein: 86-132
Range on HMM: 18-64/339.0
TLLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPH
 |  .|  .   .|.......|| . ||||||| ||| ..| ||.| 
elchrareliwsepiflkleapicvmgdihgqfddllamldmngwpl
subfamily_PPPLV_pd Subfamily PPPLV 87-339 1e-57 188.7 In-house 5-279 (290) alignment 
Range on Protein: 87-339
Range on HMM: 5-279/290.0
LLFHAFSIFNKQPMLIEVNSPINICGDIHGQFSDLLrLFDKN----GF-PHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINR
|   |  |. ..  |.|..||. . ||.||.. ||   |.|     |     |..||||||||||.. .| |  |.| ||..| ....||||||   .  
lcdvavdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

QYGFYEECQRRYNK--PSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQL---RAIKRPF-DNPEPNTLAIDILWSDPTN-----------FQ
.. .. |.. .. .   .||..|. || ..||.| . ....|.|.|. .  .  ...   . |   . |. .   ||.||||||| .            .
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

KGWNPNS-RGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKN
.|. .|. || ..||..||| ..| | ... |.|||.| . |...  . ||.|.||.  |||. ..|| ..  .|.
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdkkk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 93-349 2.7e-83 272.7 In-house 20-274 (280) alignment 
Range on Protein: 93-349
Range on HMM: 20-274/280.0
SIFNKQPMLIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINRQYGFYEECQRR
.|| ..  |.| ..||.. |||| |. |. ||||  |     . .||||||||| . .| ..|||. |. . .. ..||||||   .|. |||| ||| .
aifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqyk

YNKpSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDnPEPNTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQI
|    .|  || .|  ||...|. .|.||||||.|  | |.  .| | || . |    | ||.|||||||  .||  . ||.||.||   . .    |.|
ygv.glwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpce.pldrgllidllwsdptnkgegwfhsirgisymfgkgvveqackslei

DLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRP
||..|||||||||||..| |||.|.|| | || || |||||. .| ||  ||  | |
dliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 101-356 3e-85 279.1 In-house 2-262 (263) alignment 
Range on Protein: 101-356
Range on HMM: 2-262/263.0
LIEVNSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINRQYGFYEECQRRYNKP----
|.|...||||||| |||. ||||.|.  |   ...||||||||||| | || |.|||. |. .| ....||||||   ||..|||. | ..|...     
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

SVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDILWSDPTNFQKGWNPNS-RGVSYVFGSDALRKLLDRLQIDLV
||.  |. ||| ||| |.| .||||||||.|  |... ..|||  |..  .   || |.||.|| .  ||..||  | .| |||   .  |  ||.|||.
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

VRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKKIARR
|||||||. || |||.|||.|.|||  |  .. | |||. ||| |  ||| |.|     ||
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfevrr
Metallophos Calcineurin-like phosphoesterase 107-302 2.1e-42 138.7 Pfam-A 2-199 (200) alignment 
Range on Protein: 107-302
Range on HMM: 2-199/200.0
PINICGDIHGQFSDL----LRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLL--FAYKVIFPNHFFMLRGNHECSLINRQYGFYEECQR---------
.| ..||.||.. ||    |.|..... .   ..|||||.||||.. .||. ||  ...|. .|...|.||||||.. .|  |||..|. .         
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RYNKPSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVSQLraikrpfdnpepntlaidilwsdptnfqkgw
                         ....|..  .. .|  .|| |||...||..||..|. .... .                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

npnsrgVSYVFGSDALRKLLDRLQIDLVVRAHQVV
       |. ||.|||.||| . ..|||.|.|. .
......gselfgpdalekllekygvdlvlrGHtHk
PPP_2 108-301 1.2e-70 230.3 In-house 1-197 (198) alignment 
Range on Protein: 108-301
Range on HMM: 1-197/198.0
INICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINRQYGFYEECQRRYNKPSVWHSFQGVFS
...|||.|||..|||.||.. ..... .||||||||||||. ||..|||.|.|. .|.....||||||.. .|. |||..|....... .|.. .| ||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

VMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLaIDIL----WSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQV
..||.||. ...|..|||.|. .....| . ..|. . || ..| .| |    .|||.. ........||....||.|. ..||.. ...|..|||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegkl.ldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 108-301 5e-68 222.0 In-house 1-196 (197) alignment 
Range on Protein: 108-301
Range on HMM: 1-196/197.0
INICGDIHGQFSDL-LRLFDKNGFPH-RANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINRQYGFYEECQRRyNKPSVWHSFQGV
. ..||||||. || |.|... |.|. . .|.||||||||||. ||..|||.|.|. .|.....||||||.. .|. |||..|.... .. .... .| |
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDI-LWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQV
|...||.||. ...|..|||.|. |........|.|... |  .... |. |||||.. |.|.... ||....||.|. .|.|.. ...|..|.|..
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 108-302 8.4e-66 214.7 In-house 1-199 (199) alignment 
Range on Protein: 108-302
Range on HMM: 1-199/199.0
INICGDIHGQFSDL-LRLFdKNG-FPH-RANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINRQYGFYEECQRRYNKPSVWHSFQG
. .|||.|||. || |.|| |.| .|  . .|.||||||||||. ||..|||.|.|. .|.....||||||.. .|. |||..|....|.. .... .. 
vtvcGDlHGqlddlllilf.keggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsd

VFSVMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDI-LWSDPTNFQKG-WNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVV
||...||.||. ...|..|||.|. ......|..|.|... || .    |. |||||.. |.| . .. ||....|| |. .|.|.. ...|..|.|...
vfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 134-350 2e-93 306.1 In-house 101-315 (317) alignment 
Range on Protein: 134-350
Range on HMM: 101-315/317.0
ANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINRQYGFYEECQRRYNKpSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNV
 .||||||||||| . .| ..||||.|. .|.. |.||||||   .|.|||||.|...||.. .....|| .| |.||.|.|...|||||||.|. | ..
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

SQLRAIKRPFDNPEPNTLAiDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAV
.|| ..|||.| |.   || |. |.|| .  ||... .|| . |||..|....|..|..||||||||||.|||||||.|.||||||||.||||.||.|||
kqldklkrpldipdvGvla.dltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

MYVNKNLVCSFVVLRPR
. |.|.|..|. |||| 
lsvdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 135-351 7.5e-74 241.8 In-house 121-335 (339) alignment 
Range on Protein: 135-351
Range on HMM: 121-335/339.0
NYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINRQYGFYEECQRRYNKpSVWHSFQGVFSVMPLTALVGQRILCMHGGVSKMLQNVS
 |||||||||||   .| ..|| | |. .|.. ..||||||   .|  |||| | . ||.   ..  || .| |.|. |.. . |.|||||.|. |  . 
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QLRAIKRPFDNPEPNTLaIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVM
|.  .|||.. |.   |  |. |.||   .||..| .|| |.|||  ||| .| .|....|.| ||||.||||||  |||||||||| |||| ||.|||.
qfsvfkrpleipdvgvl.tdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavf

YVNKNLVCSFVVLRPRK
 ..|.|  |  |.||  
sidkklkisinvfrpes
subfamily_PPP7C_pd Subfamily PPP7C 253-352 1.3e-20 66.4 In-house 238-337 (383) alignment 
Range on Protein: 253-352
Range on HMM: 238-337/383.0
IDILWSDPTNfQKGWNPN-SRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRK
.||||||| . ..| .||  ||    ||.|  .|||.. ...|..|.|.  ..||||  .....|||||  |  .  |  | . ..|.|   .|     |
ldilwsdpka.keGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqask

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