Gene F33A8.6 in Caenorhabditis elegans

Synonym: CELE_F33A8.6, F33A8.6

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily ILKAP
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP074_AA protein Get Run
CeleP074_AA_21-316 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 22-316 3.6e-65 212.6 In-house 11-290 (295) alignment
Range on Protein: 22-316
Range on HMM: 11-290/295.0
KPKESRNLYCTLAAYGCRKGERADMQDTHIMLPKFDLGTEKsflsrASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAK-FSDFPTLTKSLKQTFTESYK
. . |  |... ... . .| |  ..| ..... .  ..|.      ..|..|||| | .|||.... . ....| | | .   .. . .... ......
llllsslllllrvgvasdqGrrksneDavlvvlnllslled.....lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkafl

AVDDGFLAIAKQNKPIWKDGTTATTMIILNNVIYVANIGDSRAVVARKKedgsfAPVCLTVDHDPMSHDERMRIQKAGAVVKDGRINGVIEVSRSIGDLP
|.|  .|. | ...  .  ||||....| .| .||||.||||||. |..      .|.|||||.|.. .||.||..|| .| .||.|||. |.|..|| .
aadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrng.....elvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfd

FK--------SLGIISTPDLKKLTLT-KNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKtdieqepnesreaaeLRVVAEKLAAEAVRRKCGDNVSV
.|        . .....||.. |.|| ..| | ..|.||||. .|| |.|... . |.  .                | ..||.|. .|..| . ||..|
lklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld...............leeaaeeLvdlAlargsrDNiTv

IIVKL
..|.|
vvvrl

subfamily_PPM1A_pd Subfamily PPM1A 22-316 1.3e-54 178.4 In-house 2-280 (282) alignment
Range on Protein: 22-316
Range on HMM: 2-280/282.0
KPKESRNLYCTLAAYGCRKGERADMQDTHIMLPKFDlgTeksfLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKE--KLAKFSDFPTLTKSLKQTFTESY
|||.. ..    ..    .| |..| |.|..  ..   .    |.  ||||.|||||| ..|....... ... |  .| . .   . ....|... ...
kpksqaegnglrygvssmqgwrvemEDahtvvaslg..a....lkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgf

KAVDDGFLAIAKQNKPIWKDGTTATTMIILNNVIYVANIGDSRAVVARKKedgsfAPVCLTVDHDPMSHDERMRIQKAGAVVKDGRINGVIEVSRSIGDL
 |.|.   .  ...|   | |.||.|... .. ...||.||||||..|..     . . || || |.. .|. ||..||  |  .|.|| . |||..|| 
LaldeairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrng.....kaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDy

PFKS--------LGIISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKTDIEqepnesreaaelrvvAEKLAAEAVRRKCGDNVSV
 .|.        . ... |. . .  ...| | ..||||.|   |. |.|... ..||.|..                   |..|  .| ..  .||.||
eykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev...............akalvdkalekgsrDNlsv

IIVKL
..| .
lvvlf

subfamily_PPM1G_pd Subfamily PPM1G 24-116 1.6e-08 27.0 In-house 9-93 (473) alignment
Range on Protein: 24-116
Range on HMM: 9-93/473.0
KESRNLYCTLAAYGC--RKGERADMQDTHIMLPKFDlgteksflSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKlAKFSDfPTLTKSLKQTFT
||| . ...  .||.   .| |... |.| .....|        .  |.||..||| |   |... ... . .|..   . .   ..|.|...| 
kesedesneelsygasamqGwrvsqEDahncitdld........edtslfavyDGHGGkevakyvakklpdllkaq.kgyke.gdvekaleeafl

subfamily_PPM1G2_pd Subfamily PPM1G2 28-316 7.8e-45 146.0 In-house 16-286 (287) alignment
Range on Protein: 28-316
Range on HMM: 16-286/287.0
NLYCTLAAyGCRKGERADMQDTHIMLPKFdlgTEKSFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEklakFSDFPtlTKSLKQTFTESYKAVDDGFL
|  .....  . .| | .| |.||. ...    |||  .....||.|||| | ..|... ... |....     ..|     .|.| . ......|  .|
naltkvgs.samqGyrlnmeDahilenel...leksddkslalfavfDGhGGakvakyagkklikkiak....kksfk..egaleqilkdafletDeell

AIAKQNKpiWKDGTTATTMIILNNVIYVANIGDSRAVVARKKEdgsfaPVCLTVDHDPMSHDERMRIQKAGAVVKDGRINGVIEVSRSIGDLPFKSLG--
   | ..   . |.||....| .. .||||.||||||.. | .        |..|| | ...|. ||..|| .|. .|.||.. .||..||  ||.    
kdeklkd..esaGstavvvlikeeklyvanaGDsravlsskgn.....vkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkk

------IISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKTDieqepnESREaaelRVVAEKLAAEAVRRKC-GDNVSVIIVKL
      .  .||.    |...| | ..||||.|  ..| | | .  |.|   .| |      |  |    ... . || ..       ||..|.|| |
kpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakld......eiie....elldkclapdssntgvGcDnmtvvivvl

subfamily_ILKAP_pd Subfamily ILKAP 29-316 5.9e-132 432.2 In-house 2-292 (293) alignment
Range on Protein: 29-316
Range on HMM: 2-292/293.0
LYCTLAAYGCRKGERADMQDTHIMLPKFD--LGTEKSFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKfSDFPTLTKSLKQTFTESYKAVDDGF
||.. .||..|||||..|||.|..| ..|  |..|||..||.|..|.||||||.||.|...... |...|||.| ||. . .|..|.....|.|..|. |
lyklkgayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsakekeikkclvdsfkktdeef

LAIAKQNKPIWKDGTTATTMIILNNVIYVANIGDSRAVVARKKEDGS-FAPVCLTVDHDPMSHDERMRIQKAGAVVKDGRINGVIEVSRSIGDLPFKSLG
|..|...||.||||.|||....|.||.||||.|||.||..||||.|. .| |.||.||.|....||.||||||.||.|||..||.||||||||  ||.||
LklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG

IISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAA-KKTDIEQEPNESREAAELRVVAEKLAAEAVRRKCGDNVSVIIVKL
.|||||.||..||.||||...|||||||.||. |.|.|....||.. ....|..|...|.|.....|....||.|||.|...|||.|..||.
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvki

PP2Cc_SM00332 35-314 5.2e-62 202.7 In-house 11-274 (274) alignment
Range on Protein: 35-314
Range on HMM: 11-274/274.0
AYGC--RKGERADMQDTHIMLPKFDlgteksFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPtlTKSLKQTFTESYKAVDDGFLAIAKQ
.||.   .|.|  |.| |.. ....        ....||..||||.|...|. ..... . .||.| | .|     .. ..   ......|. .|. ...
sygkssmqgwrksmeDahvvvvdlv......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel..eddveealkkaflstdeeileeeqs

NKP-IWKDGTTATTMIILNNVIYVANIGDSRAVVARKKEdgsfaPVCLTVDHDPMSHDERMRIQKAGAVVKDGRINGVIEVSRSIGDLPFK------SLG
...  .. |.||..... .. .||||.||||||..|...      | |.||| |   ||| ||.|||.||..||.||...|||..||  .|      . .
kelenalsGstavvallkkedlyvanvGDSravlcrngk.....avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknkklkepy

IISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAkktdieqepnesrEAAELRVVAEKLAAEAVRR-KCGDNVSVIIV
|...|| | .|||..| | |.|.|||| ..|| |.|..  ..|.               .  .   .||.|..|| || .. ||..|..|
itaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg.............ktndpqeaaelldeeairrggseDniTvvvv

0049733 PP2C-like 35-316 1.9e-48 157.8 In-house 6-233 (235) alignment
Range on Protein: 35-316
Range on HMM: 6-233/235.0
AYGCRKGE-RADMQDTHIMlpkfdlgteksflsRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKfsdfpTLTKSLKQTFTESYKAVDDGFLAIAKQN
.. ...|  |  ..|....                ..||..||| | .|.|.. ... .|..| |..     .|. .|.. ......|... .|. |...
gaasdigrvrkvneDavlv..............glllfavaDGhgghaagevasellvetllellle.....lllldleealrkaflaaneallelalas

KPIWKDGTTATTMIILNNVIYVANIGDSRAVVARKKEdgsfaPVCLTVDHDPMSHDERMRIQKAGAVVkdgRINGVIEVSRSIGDLPFKslgiistPDLK
....  ||||..... .. .||||.|||||.. |...      |.||.|| |. ..||.||..|| .|   |..|.. ..|..|||..|       ||. 
pelagmgtTavvalldggklyvanvGDsrayllrdgk.....lvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.......pdvt

KLTLTKNDlFAIIACDGLWKSFSNLEAVSFAVEqleaakktD-IeqepnesreaaelRVVAEKLAAEAVRRKCGDNVSVIIVKL
 |.|...| | ..|.||||. .|. |.|..  .        . .             . .||.|. .|..|   ||..|..|.|
vlelepgd.flllasDGlwdvlsdeeivdllrs........ldl.............eeaaerlvelalarggrDNiTvvvvrl

subfamily_PPM1D_pd Subfamily PPM1D 37-210 1.9e-27 89.2 In-house 7-178 (309) alignment
Range on Protein: 37-210
Range on HMM: 7-178/309.0
GCRKGERADMQDTHIMLPKFDLGTEksfLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSD-FPTLTKSLKQTFTESYKAVDDGFLAIAKQ-NK
 ...|.|  |.|.  .  . .  .|       .|.|.|||| |  ||.. .... ...|..   .|.  . ... ....| .  .|.       .|. ..
eadqGgrkymeDvvaivleeeesae...elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksg

PIWKDGTTATTMIILNNVIYVANIGDSRAVVARKKE-DGSFAPVCLTVDHDPMSHDERMRIQKAGAVVKDGriNGVI
     ||||...|| .. .|||..|||..|.. |.. . .. . .||.|| | | .|. ||...|  |..   .|| 
llstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak..sGvk

subfamily_PPM1E_pd Subfamily PPM1E 38-316 6.5e-47 152.9 In-house 10-262 (265) alignment
Range on Protein: 38-316
Range on HMM: 10-262/265.0
CRKGERADMQDTHIMLPKFDLGTEKSFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDfPTltkslkQTFTESYKAVDDGFLAIAKqnKPIW
. |..|  | | |..|....   | .. .  .|||.||||.|  ||.. .... ... ..    .| |.      . . |..|..|. ||. |.  .  .
avknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklked.pa......ealkeafkltDerflqkae..rekl

KDGTTATTMIILNNVIYVANIGDSRAVVARKKEdgsfaPVCLTVDHDPMSHDERMRIQKAGAVV-K--DGRINGVIEVSRSIGDLPFKSLgIISTPDLKK
| |.|| ...| .. .||| .|||.|.. || |      | |.  | |  .||. ||..|| .| .    |.|||. |||.|||   |   ... .|. .
ksGstavvvliekdqlyvaWlGDsqallvrkge.....avqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpy.vsgeadvae

LTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEaakktdieQePNEsreaaELRVVAEKLAAEAVRRKCGDNVSVIIVKL
..|.... . |.||||||  . . |.|.   | |.        . ..|     .|  ||..| ..|  .   ||..|..| |
veldgseeylilacDGlwDvvneeevvklveefla........d.gae.....dlsevakllveaakeagssDnitvvvvfl

PP2C Protein phosphatase 2C 39-309 9.6e-58 188.7 Pfam-A 8-255 (255) alignment
Range on Protein: 39-309
Range on HMM: 8-255/255.0
RKGERADMQDTHIMLPKFDLGtekSFLSRASFFAIFDGHAGPRAAEHCQSQMGktvkEKLAKFSDFPTLTkSLKQTFTESYKA-VDDGFLAIAKQNkPIW
 .| |  | |.|| |...      |  |. .|||.||||.| .||. .....     |.|.. ..|..|.  ... . .|. |  |. .   ....   .
lqgarksmedahialknleks...sgkssvaffavfdghggreaakyarehle....eilkeqksflele.kvekalrksfladtdeelksskant.eps

KDGTTATTMIILNNVIYVANIGDSRAVVARKKEDGsfapVCLTVDHDPMSHDERMRIQKAGAVVK-DGRINGVIEVSRSIGDLPFKS---LGIISTPDLK
| |.||....| .. .||||.||||||..||...     . ||.||.| . ||| ||..||  |.  ||.||...|||..||. .|.     ... ||..
ksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvt

KLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKktdieqepnesreaaELRVVAEKLAAEAVRRKCGDNV
. .||..| | |.|.||||  .|. |||... ..|.. |               ... .||.|. ||..|.. ||.
svklteedefliLasdGlwdvlsdqeavdlvrselskkk...............spmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 39-309 9.6e-58 188.7 In-house 8-255 (255) alignment
Range on Protein: 39-309
Range on HMM: 8-255/255.0
RKGERADMQDTHIMLPKFDLGtekSFLSRASFFAIFDGHAGPRAAEHCQSQMGktvkEKLAKFSDFPTLTkSLKQTFTESYKA-VDDGFLAIAKQNkPIW
 .| |  | |.|| |...      |  |. .|||.||||.| .||. .....     |.|.. ..|..|.  ... . .|. |  |. .   ....   .
lqgarksmedahialknleks...sgkssvaffavfdghggreaakyarehle....eilkeqksflele.kvekalrksfladtdeelksskant.eps

KDGTTATTMIILNNVIYVANIGDSRAVVARKKEDGsfapVCLTVDHDPMSHDERMRIQKAGAVVK-DGRINGVIEVSRSIGDLPFKS---LGIISTPDLK
| |.||....| .. .||||.||||||..||...     . ||.||.| . ||| ||..||  |.  ||.||...|||..||. .|.     ... ||..
ksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvt

KLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKktdieqepnesreaaELRVVAEKLAAEAVRRKCGDNV
. .||..| | |.|.||||  .|. |||... ..|.. |               ... .||.|. ||..|.. ||.
svklteedefliLasdGlwdvlsdqeavdlvrselskkk...............spmeaaeelvdeaiargsedni

PPM_PTC7 39-309 3.8e-55 180.1 In-house 8-259 (259) alignment
Range on Protein: 39-309
Range on HMM: 8-259/259.0
RKGERADMQDTHIMLPKFDLGtekSFLSRASFFAIFDGHAGPRAAEHCQSQMGktvkEKLAKFSDFPTLTkSLKQTFTESYKA--VDDGFLAIAKQNkPI
 .| |  | |.|| |...      |  .  .|||.||||.| .||. .....     |.|.. ..|..|.  |.. ...|. |   |. .   .. .   
fqgfrksmedahialanless...sgkdsvaffavfdghggreaakyarehle....eilkerksfeele.klekalrksflaldtdeelksseant.ep

WKDGTTATTMIILNNVIYVANIGDSRAVVARKKEDGsfapVCLTVDHDPMSHDERMRIQKAGAVVK---DGRINGVIEVSRSIGDLPFKS-----LGIIS
.. |.||.. .| .. .||||.||||||..|....     . ||.||.| . ||| ||..||  |    .||.|||..|||..||. .|.       ...
stsGstAvvalitgsklyvAnvGDSravLcrsgnav....kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsa

TPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAkktdieqepnesreaaELRVVAEKLAAEAVRRKCGDNV
.|| .. .....| | |.|.||||  .|. |||... ..|..                 ... .||||. ||..|.. ||.
ePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk................dpmeaaeklvdeaiargsedni

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 41-316 5.8e-43 140.0 In-house 15-253 (255) alignment
Range on Protein: 41-316
Range on HMM: 15-253/255.0
GERADMQDTHIMLPKFDLGTEKSFlsrasfFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPtltkslKQTFTESYKAVDDGFlaiakQNKPiWKDG
| |. |.|  ..  .|  .... .      .|.||||.| .||...  .. | ..|.|  ..  |      .......||...  .     ...|    |
GrrptmedelviyGsfrdksdedy......yalfdGhgGraaakfaseelykilaelldlnnanP......vkslkkaykeistqi.....serp.kfiG

TTATTMIILNNVIYVANIGDSRAVVARKKEdgsfAPVCLTVDHDPMSHDERMRIQKAGAVVKDG----RINGVIEVSRSIGDLPFKSLgIISTPDLK-KL
|||....|... .|.||.||||.|...|.       . |..|| |   .|. ||...|  |  .    |.|| . |||..||  ..   ... |||. .|
ttaasvliiedkvyianvGdsrvvlcqkdg....takrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePf.vvpdPdlsqsl

TLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQleaakktdieQEPNEsreAaelrvvAEKLAAEAVRRKCGDNVSVIIVKL
. .|.| | |.||||.|   |. |||. ...           ..|..   |      ||||   |  .   ||.|||..||
eiskkdkflilacdGiwdlisdeeaveivagi..........sdpek...a......aeklrdlayssGstdnisvivikl

subfamily_PPM1L_pd Subfamily PPM1L 41-316 6.2e-42 136.7 In-house 14-266 (269) alignment
Range on Protein: 41-316
Range on HMM: 14-266/269.0
GERADMQDthimlpKFDLGTEKSFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPTLTK--SLKQTFTESYKAVDDGFLAIAKQNKPIwk
| |  |.|      .|.. .. .     ||||.|||| |  |||.... . |..|.|| ..      |.  . .. .|.   .||  .|  ||... |  
Grrprmed......rfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedi..

DGTTATTMIILNNVIYVANIGDSRAVVARKkeDGsfAPVCLTVDHDPMSHDERMRIQKAGAVVK---DGRINGVIEVSRSIGDLPFKSLG-IISTPDLKK
 ||||   .. .. . |||.|||| |.  |  .|    . |. || |    || ||.|||  .      |..||. .||..|| |.|    .|..||.  
aGttalialvqesdlivanvGdsrGvlydk..rG..kaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdilt

LTLTK-NDLFAIIACDGLWKSFSNLEAVSFAVEQLEaakktdieqEPNesreaaelrVVAEKLAAEAVRRKCGDNVSVIIVKL
. | . .  | |.|.|||| .||| ||| |. |.|.         ||.           |  |. |. .| . ||..|..|||
fdlddhkpeflilasdGlwdtfsneeavrfikerlk.........epd.........fGakslvlesfkrGsvdnitvlvvkl

PPM_PTC7_SpoIIE 43-271 2.8e-26 85.7 In-house 12-212 (230) alignment
Range on Protein: 43-271
Range on HMM: 12-212/230.0
RADMQDTHIMLPKFDLGtekSFLSRASFFAIFDGHAGPRaaEHCQSQMGKTVKEKLAKFSDfpTLTKSLKQTFTESYKAVDDGflaiakqnkpIWKDGTT
|  | |.|| ....      |  . | .....||| |.     . ... ....|   . ..  .. . |. .. . ... .|            .. |.|
rksmedahispanseks...sggrlalvvgdvdGhGgra..alamgllrtalrelafagle..kpeeilrrlnlalaadlede..........psssgaT

ATTMIILNNV--IYVANIGDSRAVVARKkEDGsfapvcltvdhdpmshdERMRIQKAGAV-V--KDGRINGVIEVSRSIGDLPFK-SLGIISTP-DlKKL
|.  .| ..   .|||| |||.... |. ..|                 || ||.  |.. .   .||..|| .||...||| .. . |...   |  . 
avvalidpstgklyvanaGdsppllvrd.dgg.................ererivagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.tsd

TLTKN-DLFAIIACDGLWKSFSNLEAVSFAVEQLEAA
..... | |.|.|.||||   |. |.|......||. 
gelfgkdeflilasdglwdvlspqelvdlvrdelekp

subfamily_KAPP-like_pd Subfamily KAPP-like 44-316 1.3e-29 96.1 In-house 10-266 (266) alignment
Range on Protein: 44-316
Range on HMM: 10-266/266.0
ADMQDTHIMlpKFDLGTEKS--FLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKfsdfpTLTKSLKQTFTESYKAVDDGFLAIAKQNKPIWKDGT
  |.| ..   .. |. ||     |. ..||.||||||  ||.  .  . | ....| .     |  .   .   .  | ... |  . .. |    .|.
temedvsla..iypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllks.....tkqddGGdniydqskllenafkevdaklkdfeyeGa

TATTMIILN----NVIYVANIGDSRAVVARKKEDgsfapVCLTVDHDPMSHDERMRIQKAGAVVKDG--RINGVIeVSRSIGDLPFKS--LGIISTPDLK
|||  .. .      . |||.||| | ..|  |      . |. ||     .|. ||.. |  . |.  ||||.. |||..||   |   .|.||.| . 
tatlalvwsdGqqrylqvanvGdssaflsrGnes.....lelskdhkakdpeekqrikddGitlsdnqtrinGla.vsralGdhfikelniGlisepyvs

-KLTLTKNDLFAIIACDGLWKSFSNLEAVsfavEQLEAAKktDiEQEPNESREAAELRVvaeklAaeAVRRKCGDNVSVIIVKL
 ...||  | | |.| ||||   |  .|.    |....    | .|. ...  .. |..     |      |. ||||||.|||
nrilltpfdkflivasdGlwdvisGkdai....ekvksly..d.qqatedkmassllet.....a..iqsikakdnvsvivvkl

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 44-316 2.8e-27 88.3 In-house 9-276 (276) alignment
Range on Protein: 44-316
Range on HMM: 9-276/276.0
ADMQDTHIMlpKFDLGTEKS--FLSRASFFAIFDGHAGPRAAEHCQSQMGKTVkEKLAKFSDFpTLTK--SLKQTFTESYKAVDDGFLAIAKQNKPIWKD
  |.| ..   .. |. ||     |. ..||.||||||  ||.  .  . | . ||| | ... .|||     .   .  | . | |  . .. |    .
temedvsla..iyplldekdlsncsnialfavfdGhaGkGaadaakklfpkel.ekllksgny.sltkqddGGdniydqskllldlfkevdaklkdfeye

GTTATTMIILNNV----------IYVANIGDSRAVVARKKEDgsfapVCLTVDHDPMSHDERMRIQKAGAVVKDG--RINGVIeVSRSIGDLPFKS--LG
|.|||  .. ..           . |||.||| | ..|  |      . |. ||     .|. ||.. |  . |.  ||||.. |||..||   |   .|
GatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGnes.....lelskdhkatdpeekqrikddGitlsdnqtrinGla.vsralGdhfikelniG

IISTPDLK-KLTLTKNDLFAIIACDGLWKSFSNLEAVsfavEQLEAAKktDiEQEPNESREAAELRVvaeklAaeAVRRKCGDNVSVIIVKL
.||.| .  ...||  | | |.| ||||   |  .|.    |....    | .|. ...  .. |..     |      |. ||||||.|||
lisepyvsnrilltpfdkflivasdGlwdvisGkdai....ekvksly..d.qqatedkmassllet.....a..iqsikakdnvsvivvkl

subfamily_PP2D1_pd Subfamily PP2D1 44-131 7.2e-09 27.9 In-house 15-103 (492) alignment
Range on Protein: 44-131
Range on HMM: 15-103/492.0
ADMQDTHIMLPKFDLGTEKsflsraSFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPTLTKSLKQT-------FTESYKAVDDGFLAIAK
..|.|.. .  .|   ...      .||.|.||. |  ||| . ... . . |.|.|. .  .|| . ..        . . . ...| . || |
skmeDkrtlqdyfgndvns......cFfgiyDGynGataAeiaakelhevlleelekvdervslttavnlidnndltdyelerasrsdsirailk

subfamily_PDP_pd Subfamily PDP 63-113 8.3e-06 18.1 In-house 20-70 (398) alignment
Range on Protein: 63-113
Range on HMM: 20-70/398.0
SFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPTLTKSLKQ
.  |.. .|..||||.|  .||. . .. | |  .| | ..  . .| |..
llesngvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekales

subfamily_PHLPP_pd Subfamily PHLPP 67-273 1.1e-14 46.9 In-house 26-224 (246) alignment
Range on Protein: 67-273
Range on HMM: 26-224/246.0
RASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDfptLTKSLKQTFTESYKAVDD-G-FLAIAKQNKPIWKDGTTATTMiilnNVIYVANIGDSRAV
. . . .|||..    ..  |  | . .||.. | ..    .. .|.|.  . . .   |  |  |     | .|    ..      .. ||..|   ||
vealyGlfdGdrneelssllqrlmkdvlkeevqkdkn...eeeymkntllvaqrklGeaGeklgsaallilirhdkvdPaks....fsLevAsvGtlqav

VARKKEdgsfaPVCLTvDHDPMSHDERMRIQKAGAVV-KDGRINGVIEVSRSIGDLpFKSLGIISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSF
..|...     .. |.  .. ...||  ||..| |..  |..|||||| .| .| . |    .. .| .....||..| . |.  . ||...|  |||. 
liRngk.....klrls.ksyviekdelkrikeakaiitednkingviestrllGyt.flfPvvlPkphvrevlLteqdellivGnkalWevlsideavea

A---VEQLEAAKK
     . | ||||
vrkeedplvaAkk

Subfamily Dicty-PPM1L-like 68-317 1.3e-17 56.6 In-house 37-304 (305) alignment
Range on Protein: 68-317
Range on HMM: 37-304/305.0
ASFFAIFDGHAGPRAAEHCQSQM----GKTVKEKLAKFSDF-PTLTKSLKQTFTESYKAVDDGFLAIAKQNKPiwKDGTTA----TTMIILNNVIYVANI
 |.| .|||| | .|||. . ..     | |||  . .|       ..  ..  ... . |  .|. |. .    | |||     ...|. .. . |.. 
lslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnk..kaGttlngssasvilerertivsta

GDSRAVVARKK--EDGSFA--PVCLTVD------------HDPMSHDERMRIQKAG-AVVKDGRI--NGVIEVSRSIGDLPFKSLgIISTPDLKKLTLTK
.|. .|..     |  | .  |. . .|            .. . ...|.||. .. |... |..  |.....|||.||   | | .|  .| . | ..|
sdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellvnrllkksrskGdknlkel.viPnndspllvvak

-NDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKTD-IEQEPNESReaaelRVVAEklaaEAVRRKCGDNVSVIIVKLE
 || | ..| ||||. .|. . | .  | |.  ..   || ..||       ||..|    |||.|  |||. ..|.||.
anDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneis.....rvive....eavkrgsgDnitlviiklk

subfamily_PPM1H_pd Subfamily PPM1H 68-121 3.3e-07 22.4 In-house 62-115 (404) alignment
Range on Protein: 68-121
Range on HMM: 62-115/404.0
ASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPTLTKSLKQTFTESYKA
  .|..||||||. ||  .  .. |..|||| .  .. . ... ....||. . 
layfglfDGhaGsgaalvaskllhkhlkekledvlellleksaeeeenteessk

subfamily_PPM1K_pd Subfamily PPM1K 69-268 2.8e-35 114.7 In-house 32-228 (263) alignment
Range on Protein: 69-268
Range on HMM: 32-228/263.0
SFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDfptLTKSLKQTFTESYKAVDDgFLAIAKQNKPIWKDGTTATTMIILNN-VIYVANIGDSRAVVAR
 ..|.||||||. ||... ... |..|. | |  |   | . ||..| |  |..   .|     ..   . |||||  .. .   . .|..|||||.. |
lyvavfdGhaGsaaadfvhdklekilkrllekekd...leivlknafeeldkklkr.ylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcr

KKEdgsfaPVCLTVDHDPMSHDERMRIQKAGAVVK-----DGRINGVIEVSRSIGDLPFKSLGIISTPDLKKLTL-TKNDLFAIIACDGLWKSFSNLEaV
. .     . .|| ||||  ..|. ||..||  |.       ..||.. ..||.||| .|. |.|.||. |.| .  ..| | ..  ||.    .. | .
nGk.....akkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqe.l

SFAVEQL
.. |.. 
cdlvrlc

PP2C_SIG_SM00331 69-316 4.2e-13 42.4 In-house 31-217 (217) alignment
Range on Protein: 69-316
Range on HMM: 31-217/217.0
SFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPTLTKSLKQTFTESykavddgflaiakqnKPIWKDGTTATTMII--LNNVIYVANIGDSRAVVA
 .....||. .  ||. . ||. . ..| | . ...... | | . . |                |     ..|.. ...   .. ...||.|||| .. 
lllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee...............keekgmfaTlllalydfssgklsyanaGdsrpyll

RkkEDGSFAPVCLtvdhdpmshdermriqkagavvkdgringvievsrsigdLPFKSLGIISTPD--LKKLTLTKNDLFaIIACDGLWKSFSNLEavsFA
|  ... . ..                                          . . ||......   ..|.| | ||. ... |||.   |  .   ||
r..dgklveilkd.......................................vegaplGlepevsvdirelelekgdll.llytDGltearsekg...fa

VEQLEAAKKTDIeqepneSREAAELRV-VAEKLAAEAVRRKCGDNVSVIIVKL
 |.|| . ..        . ||.||     |.| ..| ...  |...|..||.
eerleeiledlv......dseaqelaqkiveellelakgsngeDdiTvvvvkv

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 70-232 1.6e-16 53.7 In-house 22-196 (292) alignment
Range on Protein: 70-232
Range on HMM: 22-196/292.0
F-FAIFDGHA--GPRAAEHCQSQMGKTVKEKLAKFSDfptLTKSLKQTFTeSYKAVDDGFLAIAKQnkpiwKDGTTATTMIILNN-VIYVANIGDSRAVV
|  |..|||   | . |.  ...... . |   .  .   |...| .    .  |  |   . |..     . .|...  .. ..  ...||.|||||..
flaavldGhGvnGdkvaqlaedtlevelleltrqlqe...lsealllril.diaakldkltidare.....sattavvcarvrddralilanvGdsrall

ARKKEDGSFAPVCLTVDHDPMSHDERMRIQKAGAVVK-----------DGRI------NGVIEVSRSIGDLPFKSLGIISTPDL
 |      . .. |. || |   ||| ||..||  |.             |.      .| . .||..||. ..  |... |.|
grclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePel

subfamily_PPM1G_pd Subfamily PPM1G 133-281 1.7e-34 112.7 In-house 290-436 (473) alignment
Range on Protein: 133-281
Range on HMM: 290-436/473.0
NKPIWKDGTTATTMIILNNVIYVANIGDSRAVVARKkedgsFAPVCLTVDHDPMSHDERMRIQKAGAVVK-DGRINGVIEVSRSIGDLPFK--------S
..|  . ||||. ... .. ..|||.||||.|..|.        . | .|| |  . |. ||.|||  |. |||.|| . .|| .||  .|         
eepGedsGttAvvaLlkekklivAnaGDsRcvlsrn.....GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplke

LGIISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKTdieqepN
  |   ||.|.||||..| | ..||||.| . .  | | |  ..|.  ...       
qmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees......v

subfamily_PPM1H_pd Subfamily PPM1H 137-197 1.6e-09 30.0 In-house 160-213 (404) alignment
Range on Protein: 137-197
Range on HMM: 160-213/404.0
WKDGTTATTMIILNNVIYVANIGDSRAVVARKKEDgsfapVCLTVDHDPMShdERMRIQKA
 | | ||   ..|.. .|||| |||||.. ||.|      . |  |. | .  || |.|. 
ikGGCtalvalvllgklYvanaGDsRailvrkdei.....iplsadftPet..eRqRlqel

subfamily_TAB1_pd Subfamily TAB1 138-223 7.4e-15 47.6 In-house 128-214 (333) alignment
Range on Protein: 138-223
Range on HMM: 128-214/333.0
KDGTTATTMIILNNVIYVANIGDSRAVVARKKEdgSFAPVCLTVDHDPMSHDERMRIQKAGA---VVKDGRINGVIEVSRSIGDLPFKS
..||||   .|.|| .||||.|||||.. ..||  |   . | |||.   .|| .|... |     .|  .. |  |  |||||.  | 
sgGttAvvalifnnkLyVaNvGdsrAllvkrke..sekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkk

subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 139-259 7e-08 24.0 In-house 134-273 (317) alignment
Range on Protein: 139-259
Range on HMM: 134-273/317.0
DGTTATTMIILNNV-IYVANIGDSRAVVARKK------EDGsFAPVCLTVDHDPMSHDERMRIQ----KAGAVVKDGRING--------VIEVSRSIGDL
 ||||.  ...... . ||| ||. |.|. ..       || .    |.| |.  |..|| |..    .|. | .|| .           . ...|.|  
fGttavvavvvdethvvvanaGdaaalvllrdqaghedrdG.lsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhk

PFKSLGIISTPDLKKLTLTKNDLFAIIAC-DGLWKSFSNLE
 .|  |.|  |. .  .|  .. ||.... ||.   ...|.
llkraGviadPevrsrvldvdevfavvvvsdGitdelkrld

subfamily_PDP_pd Subfamily PDP 140-222 9.5e-14 44.3 In-house 153-241 (398) alignment
Range on Protein: 140-222
Range on HMM: 153-241/398.0
GTTATTMIILNNVIYVANIGDSRAVVARKKEDGSFAPVCLTVDHDPMSHDERMRIQKA------GAVVKDGRINGVIEVSRSIGDLPFK
|..|..  | .. ..|||.||.|||.....|.||.  | |. |.   ...|  ||.|.       .|...||. | .  .|  ||. .|
GacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryK

subfamily_PP2D1_pd Subfamily PP2D1 147-281 7.4e-22 70.7 In-house 184-320 (492) alignment
Range on Protein: 147-281
Range on HMM: 184-320/492.0
IILNNVIYVANIGDSRAVVARKkedGSFapVCLTVDHDPMSHDERMRIQKAGAVV----KDGRINGVIEVSRSI---GDLPFKSlGIISTPDLKKLTLTK
 .   |.|.||.|. .||. |.   |.   ..|| .|.|  . || |..|||.||    | |..||.... | .   ||.  |.  .|  | ..  .|..
leelgvlyianaGnvqAvLcre...Gka..iiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkk.svipePkttsvklde

NDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAK-KTDIEQEPN
.. | ..|  |||. .|. | .| . . |.  | ..  |. |.
aaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvpd

subfamily_PPM1D_pd Subfamily PPM1D 211-317 2.8e-09 29.5 In-house 202-308 (309) alignment
Range on Protein: 211-317
Range on HMM: 202-308/309.0
EVSRSIGDLP----FKSLGIIS-TPDLKKLTLTKNDL-FAIIACDGLWKSFSNLEAVSFAVEQlEAAKKTDIEQEpnesrEAAELRVVAEKLAAEAVRRK
 |.||.|||     ..   ..|  ||.|. ||. |.  | |.| ||||.  .  .|||.  .. |. |..  ||.     .    ..| | |   . .. 
avaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvveke.eekkelkeeqs.....rsvakalvkealqrwrskkl

CGDNVSVIIVKLE
  ||||||.| ||
raDnvsvivvile

subfamily_PDP_pd Subfamily PDP 227-286 1.3e-07 24.0 In-house 271-331 (398) alignment
Range on Protein: 227-286
Range on HMM: 271-331/398.0
ISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKT-DIEQEPNESREA
...|.. .  |..|| | ..| |||| ..|| |.||  .| |. .|.. ....|...    
taePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlk

PPM_PTC7_motif 245-309 5.5e-08 26.2 In-house 1-51 (51) alignment
Range on Protein: 245-309
Range on HMM: 1-51/51.0
IIACDGLWKSFSNLEAVSFAVEQLEAAKKtdieqepnesreaaELRVVAEKLAAEAVRRKCGDNV
|.|.||||  .|. |||... .||.. ..              ..  .||||. ||. | . ||.
iLAsDGLWDvlsdqeavdlvrdqlskkgl..............spqeaAeklvdealargseDni