Gene F33A8.6 in Caenorhabditis elegans

Synonym: CELE_F33A8.6, F33A8.6

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily ILKAP
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP074_AA protein Get Run
CeleP074_AA_21-316 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 22-316 3.6e-65 212.6 In-house 11-290 (295) alignment 
Range on Protein: 22-316
Range on HMM: 11-290/295.0
KPKESRNLYCTLAAYGCRKGERADMQDTHIMLPKFDLGTEKsflsrASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAK-FSDFPTLTKSLKQTFTESYK
. . |  |... ... . .| |  ..| ..... .  ..|.      ..|..|||| | .|||.... . ....| | | .   .. . .... ......
llllsslllllrvgvasdqGrrksneDavlvvlnllslled.....lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkafl

AVDDGFLAIAKQNKPIWKDGTTATTMIILNNVIYVANIGDSRAVVARKKedgsfAPVCLTVDHDPMSHDERMRIQKAGAVVKDGRINGVIEVSRSIGDLP
|.|  .|. | ...  .  ||||....| .| .||||.||||||. |..      .|.|||||.|.. .||.||..|| .| .||.|||. |.|..|| .
aadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrng.....elvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfd

FK--------SLGIISTPDLKKLTLT-KNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKtdieqepnesreaaeLRVVAEKLAAEAVRRKCGDNVSV
.|        . .....||.. |.|| ..| | ..|.||||. .|| |.|... . |.  .                | ..||.|. .|..| . ||..|
lklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld...............leeaaeeLvdlAlargsrDNiTv

IIVKL
..|.|
vvvrl
subfamily_PPM1A_pd Subfamily PPM1A 22-316 1.3e-54 178.4 In-house 2-280 (282) alignment 
Range on Protein: 22-316
Range on HMM: 2-280/282.0
KPKESRNLYCTLAAYGCRKGERADMQDTHIMLPKFDlgTeksfLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKE--KLAKFSDFPTLTKSLKQTFTESY
|||.. ..    ..    .| |..| |.|..  ..   .    |.  ||||.|||||| ..|....... ... |  .| . .   . ....|... ...
kpksqaegnglrygvssmqgwrvemEDahtvvaslg..a....lkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgf

KAVDDGFLAIAKQNKPIWKDGTTATTMIILNNVIYVANIGDSRAVVARKKedgsfAPVCLTVDHDPMSHDERMRIQKAGAVVKDGRINGVIEVSRSIGDL
 |.|.   .  ...|   | |.||.|... .. ...||.||||||..|..     . . || || |.. .|. ||..||  |  .|.|| . |||..|| 
LaldeairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrng.....kaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDy

PFKS--------LGIISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKTDIEqepnesreaaelrvvAEKLAAEAVRRKCGDNVSV
 .|.        . ... |. . .  ...| | ..||||.|   |. |.|... ..||.|..                   |..|  .| ..  .||.||
eykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev...............akalvdkalekgsrDNlsv

IIVKL
..| .
lvvlf
subfamily_PPM1G_pd Subfamily PPM1G 24-116 1.6e-08 27.0 In-house 9-93 (473) alignment 
Range on Protein: 24-116
Range on HMM: 9-93/473.0
KESRNLYCTLAAYGC--RKGERADMQDTHIMLPKFDlgteksflSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKlAKFSDfPTLTKSLKQTFT
||| . ...  .||.   .| |... |.| .....|        .  |.||..||| |   |... ... . .|..   . .   ..|.|...| 
kesedesneelsygasamqGwrvsqEDahncitdld........edtslfavyDGHGGkevakyvakklpdllkaq.kgyke.gdvekaleeafl
subfamily_PPM1G2_pd Subfamily PPM1G2 28-316 7.8e-45 146.0 In-house 16-286 (287) alignment 
Range on Protein: 28-316
Range on HMM: 16-286/287.0
NLYCTLAAyGCRKGERADMQDTHIMLPKFdlgTEKSFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEklakFSDFPtlTKSLKQTFTESYKAVDDGFL
|  .....  . .| | .| |.||. ...    |||  .....||.|||| | ..|... ... |....     ..|     .|.| . ......|  .|
naltkvgs.samqGyrlnmeDahilenel...leksddkslalfavfDGhGGakvakyagkklikkiak....kksfk..egaleqilkdafletDeell

AIAKQNKpiWKDGTTATTMIILNNVIYVANIGDSRAVVARKKEdgsfaPVCLTVDHDPMSHDERMRIQKAGAVVKDGRINGVIEVSRSIGDLPFKSLG--
   | ..   . |.||....| .. .||||.||||||.. | .        |..|| | ...|. ||..|| .|. .|.||.. .||..||  ||.    
kdeklkd..esaGstavvvlikeeklyvanaGDsravlsskgn.....vkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkk

------IISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKTDieqepnESREaaelRVVAEKLAAEAVRRKC-GDNVSVIIVKL
      .  .||.    |...| | ..||||.|  ..| | | .  |.|   .| |      |  |    ... . || ..       ||..|.|| |
kpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakld......eiie....elldkclapdssntgvGcDnmtvvivvl
subfamily_ILKAP_pd Subfamily ILKAP 29-316 5.9e-132 432.2 In-house 2-292 (293) alignment 
Range on Protein: 29-316
Range on HMM: 2-292/293.0
LYCTLAAYGCRKGERADMQDTHIMLPKFD--LGTEKSFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKfSDFPTLTKSLKQTFTESYKAVDDGF
||.. .||..|||||..|||.|..| ..|  |..|||..||.|..|.||||||.||.|...... |...|||.| ||. . .|..|.....|.|..|. |
lyklkgayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsakekeikkclvdsfkktdeef

LAIAKQNKPIWKDGTTATTMIILNNVIYVANIGDSRAVVARKKEDGS-FAPVCLTVDHDPMSHDERMRIQKAGAVVKDGRINGVIEVSRSIGDLPFKSLG
|..|...||.||||.|||....|.||.||||.|||.||..||||.|. .| |.||.||.|....||.||||||.||.|||..||.||||||||  ||.||
LklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG

IISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAA-KKTDIEQEPNESREAAELRVVAEKLAAEAVRRKCGDNVSVIIVKL
.|||||.||..||.||||...|||||||.||. |.|.|....||.. ....|..|...|.|.....|....||.|||.|...|||.|..||.
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvki
PP2Cc_SM00332 35-314 5.2e-62 202.7 In-house 11-274 (274) alignment 
Range on Protein: 35-314
Range on HMM: 11-274/274.0
AYGC--RKGERADMQDTHIMLPKFDlgteksFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPtlTKSLKQTFTESYKAVDDGFLAIAKQ
.||.   .|.|  |.| |.. ....        ....||..||||.|...|. ..... . .||.| | .|     .. ..   ......|. .|. ...
sygkssmqgwrksmeDahvvvvdlv......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel..eddveealkkaflstdeeileeeqs

NKP-IWKDGTTATTMIILNNVIYVANIGDSRAVVARKKEdgsfaPVCLTVDHDPMSHDERMRIQKAGAVVKDGRINGVIEVSRSIGDLPFK------SLG
...  .. |.||..... .. .||||.||||||..|...      | |.||| |   ||| ||.|||.||..||.||...|||..||  .|      . .
kelenalsGstavvallkkedlyvanvGDSravlcrngk.....avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknkklkepy

IISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAkktdieqepnesrEAAELRVVAEKLAAEAVRR-KCGDNVSVIIV
|...|| | .|||..| | |.|.|||| ..|| |.|..  ..|.               .  .   .||.|..|| || .. ||..|..|
itaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg.............ktndpqeaaelldeeairrggseDniTvvvv
0049733 PP2C-like 35-316 1.9e-48 157.8 In-house 6-233 (235) alignment 
Range on Protein: 35-316
Range on HMM: 6-233/235.0
AYGCRKGE-RADMQDTHIMlpkfdlgteksflsRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKfsdfpTLTKSLKQTFTESYKAVDDGFLAIAKQN
.. ...|  |  ..|....                ..||..||| | .|.|.. ... .|..| |..     .|. .|.. ......|... .|. |...
gaasdigrvrkvneDavlv..............glllfavaDGhgghaagevasellvetllellle.....lllldleealrkaflaaneallelalas

KPIWKDGTTATTMIILNNVIYVANIGDSRAVVARKKEdgsfaPVCLTVDHDPMSHDERMRIQKAGAVVkdgRINGVIEVSRSIGDLPFKslgiistPDLK
....  ||||..... .. .||||.|||||.. |...      |.||.|| |. ..||.||..|| .|   |..|.. ..|..|||..|       ||. 
pelagmgtTavvalldggklyvanvGDsrayllrdgk.....lvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.......pdvt

KLTLTKNDlFAIIACDGLWKSFSNLEAVSFAVEqleaakktD-IeqepnesreaaelRVVAEKLAAEAVRRKCGDNVSVIIVKL
 |.|...| | ..|.||||. .|. |.|..  .        . .             . .||.|. .|..|   ||..|..|.|
vlelepgd.flllasDGlwdvlsdeeivdllrs........ldl.............eeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1D_pd Subfamily PPM1D 37-210 1.9e-27 89.2 In-house 7-178 (309) alignment 
Range on Protein: 37-210
Range on HMM: 7-178/309.0
GCRKGERADMQDTHIMLPKFDLGTEksfLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSD-FPTLTKSLKQTFTESYKAVDDGFLAIAKQ-NK
 ...|.|  |.|.  .  . .  .|       .|.|.|||| |  ||.. .... ...|..   .|.  . ... ....| .  .|.       .|. ..
eadqGgrkymeDvvaivleeeesae...elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksg

PIWKDGTTATTMIILNNVIYVANIGDSRAVVARKKE-DGSFAPVCLTVDHDPMSHDERMRIQKAGAVVKDGriNGVI
     ||||...|| .. .|||..|||..|.. |.. . .. . .||.|| | | .|. ||...|  |..   .|| 
llstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak..sGvk
subfamily_PPM1E_pd Subfamily PPM1E 38-316 6.5e-47 152.9 In-house 10-262 (265) alignment 
Range on Protein: 38-316
Range on HMM: 10-262/265.0
CRKGERADMQDTHIMLPKFDLGTEKSFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDfPTltkslkQTFTESYKAVDDGFLAIAKqnKPIW
. |..|  | | |..|....   | .. .  .|||.||||.|  ||.. .... ... ..    .| |.      . . |..|..|. ||. |.  .  .
avknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklked.pa......ealkeafkltDerflqkae..rekl

KDGTTATTMIILNNVIYVANIGDSRAVVARKKEdgsfaPVCLTVDHDPMSHDERMRIQKAGAVV-K--DGRINGVIEVSRSIGDLPFKSLgIISTPDLKK
| |.|| ...| .. .||| .|||.|.. || |      | |.  | |  .||. ||..|| .| .    |.|||. |||.|||   |   ... .|. .
ksGstavvvliekdqlyvaWlGDsqallvrkge.....avqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpy.vsgeadvae

LTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEaakktdieQePNEsreaaELRVVAEKLAAEAVRRKCGDNVSVIIVKL
..|.... . |.||||||  . . |.|.   | |.        . ..|     .|  ||..| ..|  .   ||..|..| |
veldgseeylilacDGlwDvvneeevvklveefla........d.gae.....dlsevakllveaakeagssDnitvvvvfl
PP2C Protein phosphatase 2C 39-309 9.6e-58 188.7 Pfam-A 8-255 (255) alignment 
Range on Protein: 39-309
Range on HMM: 8-255/255.0
RKGERADMQDTHIMLPKFDLGtekSFLSRASFFAIFDGHAGPRAAEHCQSQMGktvkEKLAKFSDFPTLTkSLKQTFTESYKA-VDDGFLAIAKQNkPIW
 .| |  | |.|| |...      |  |. .|||.||||.| .||. .....     |.|.. ..|..|.  ... . .|. |  |. .   ....   .
lqgarksmedahialknleks...sgkssvaffavfdghggreaakyarehle....eilkeqksflele.kvekalrksfladtdeelksskant.eps

KDGTTATTMIILNNVIYVANIGDSRAVVARKKEDGsfapVCLTVDHDPMSHDERMRIQKAGAVVK-DGRINGVIEVSRSIGDLPFKS---LGIISTPDLK
| |.||....| .. .||||.||||||..||...     . ||.||.| . ||| ||..||  |.  ||.||...|||..||. .|.     ... ||..
ksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvt

KLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKktdieqepnesreaaELRVVAEKLAAEAVRRKCGDNV
. .||..| | |.|.||||  .|. |||... ..|.. |               ... .||.|. ||..|.. ||.
svklteedefliLasdGlwdvlsdqeavdlvrselskkk...............spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 39-309 9.6e-58 188.7 In-house 8-255 (255) alignment 
Range on Protein: 39-309
Range on HMM: 8-255/255.0
RKGERADMQDTHIMLPKFDLGtekSFLSRASFFAIFDGHAGPRAAEHCQSQMGktvkEKLAKFSDFPTLTkSLKQTFTESYKA-VDDGFLAIAKQNkPIW
 .| |  | |.|| |...      |  |. .|||.||||.| .||. .....     |.|.. ..|..|.  ... . .|. |  |. .   ....   .
lqgarksmedahialknleks...sgkssvaffavfdghggreaakyarehle....eilkeqksflele.kvekalrksfladtdeelksskant.eps

KDGTTATTMIILNNVIYVANIGDSRAVVARKKEDGsfapVCLTVDHDPMSHDERMRIQKAGAVVK-DGRINGVIEVSRSIGDLPFKS---LGIISTPDLK
| |.||....| .. .||||.||||||..||...     . ||.||.| . ||| ||..||  |.  ||.||...|||..||. .|.     ... ||..
ksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvt

KLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKktdieqepnesreaaELRVVAEKLAAEAVRRKCGDNV
. .||..| | |.|.||||  .|. |||... ..|.. |               ... .||.|. ||..|.. ||.
svklteedefliLasdGlwdvlsdqeavdlvrselskkk...............spmeaaeelvdeaiargsedni
PPM_PTC7 39-309 3.8e-55 180.1 In-house 8-259 (259) alignment 
Range on Protein: 39-309
Range on HMM: 8-259/259.0
RKGERADMQDTHIMLPKFDLGtekSFLSRASFFAIFDGHAGPRAAEHCQSQMGktvkEKLAKFSDFPTLTkSLKQTFTESYKA--VDDGFLAIAKQNkPI
 .| |  | |.|| |...      |  .  .|||.||||.| .||. .....     |.|.. ..|..|.  |.. ...|. |   |. .   .. .   
fqgfrksmedahialanless...sgkdsvaffavfdghggreaakyarehle....eilkerksfeele.klekalrksflaldtdeelksseant.ep

WKDGTTATTMIILNNVIYVANIGDSRAVVARKKEDGsfapVCLTVDHDPMSHDERMRIQKAGAVVK---DGRINGVIEVSRSIGDLPFKS-----LGIIS
.. |.||.. .| .. .||||.||||||..|....     . ||.||.| . ||| ||..||  |    .||.|||..|||..||. .|.       ...
stsGstAvvalitgsklyvAnvGDSravLcrsgnav....kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsa

TPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAkktdieqepnesreaaELRVVAEKLAAEAVRRKCGDNV
.|| .. .....| | |.|.||||  .|. |||... ..|..                 ... .||||. ||..|.. ||.
ePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk................dpmeaaeklvdeaiargsedni
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 41-316 5.8e-43 140.0 In-house 15-253 (255) alignment 
Range on Protein: 41-316
Range on HMM: 15-253/255.0
GERADMQDTHIMLPKFDLGTEKSFlsrasfFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPtltkslKQTFTESYKAVDDGFlaiakQNKPiWKDG
| |. |.|  ..  .|  .... .      .|.||||.| .||...  .. | ..|.|  ..  |      .......||...  .     ...|    |
GrrptmedelviyGsfrdksdedy......yalfdGhgGraaakfaseelykilaelldlnnanP......vkslkkaykeistqi.....serp.kfiG

TTATTMIILNNVIYVANIGDSRAVVARKKEdgsfAPVCLTVDHDPMSHDERMRIQKAGAVVKDG----RINGVIEVSRSIGDLPFKSLgIISTPDLK-KL
|||....|... .|.||.||||.|...|.       . |..|| |   .|. ||...|  |  .    |.|| . |||..||  ..   ... |||. .|
ttaasvliiedkvyianvGdsrvvlcqkdg....takrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePf.vvpdPdlsqsl

TLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQleaakktdieQEPNEsreAaelrvvAEKLAAEAVRRKCGDNVSVIIVKL
. .|.| | |.||||.|   |. |||. ...           ..|..   |      ||||   |  .   ||.|||..||
eiskkdkflilacdGiwdlisdeeaveivagi..........sdpek...a......aeklrdlayssGstdnisvivikl
subfamily_PPM1L_pd Subfamily PPM1L 41-316 6.2e-42 136.7 In-house 14-266 (269) alignment 
Range on Protein: 41-316
Range on HMM: 14-266/269.0
GERADMQDthimlpKFDLGTEKSFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPTLTK--SLKQTFTESYKAVDDGFLAIAKQNKPIwk
| |  |.|      .|.. .. .     ||||.|||| |  |||.... . |..|.|| ..      |.  . .. .|.   .||  .|  ||... |  
Grrprmed......rfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedi..

DGTTATTMIILNNVIYVANIGDSRAVVARKkeDGsfAPVCLTVDHDPMSHDERMRIQKAGAVVK---DGRINGVIEVSRSIGDLPFKSLG-IISTPDLKK
 ||||   .. .. . |||.|||| |.  |  .|    . |. || |    || ||.|||  .      |..||. .||..|| |.|    .|..||.  
aGttalialvqesdlivanvGdsrGvlydk..rG..kaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdilt

LTLTK-NDLFAIIACDGLWKSFSNLEAVSFAVEQLEaakktdieqEPNesreaaelrVVAEKLAAEAVRRKCGDNVSVIIVKL
. | . .  | |.|.|||| .||| ||| |. |.|.         ||.           |  |. |. .| . ||..|..|||
fdlddhkpeflilasdGlwdtfsneeavrfikerlk.........epd.........fGakslvlesfkrGsvdnitvlvvkl
PPM_PTC7_SpoIIE 43-271 2.8e-26 85.7 In-house 12-212 (230) alignment 
Range on Protein: 43-271
Range on HMM: 12-212/230.0
RADMQDTHIMLPKFDLGtekSFLSRASFFAIFDGHAGPRaaEHCQSQMGKTVKEKLAKFSDfpTLTKSLKQTFTESYKAVDDGflaiakqnkpIWKDGTT
|  | |.|| ....      |  . | .....||| |.     . ... ....|   . ..  .. . |. .. . ... .|            .. |.|
rksmedahispanseks...sggrlalvvgdvdGhGgra..alamgllrtalrelafagle..kpeeilrrlnlalaadlede..........psssgaT

ATTMIILNNV--IYVANIGDSRAVVARKkEDGsfapvcltvdhdpmshdERMRIQKAGAV-V--KDGRINGVIEVSRSIGDLPFK-SLGIISTP-DlKKL
|.  .| ..   .|||| |||.... |. ..|                 || ||.  |.. .   .||..|| .||...||| .. . |...   |  . 
avvalidpstgklyvanaGdsppllvrd.dgg.................ererivagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.tsd

TLTKN-DLFAIIACDGLWKSFSNLEAVSFAVEQLEAA
..... | |.|.|.||||   |. |.|......||. 
gelfgkdeflilasdglwdvlspqelvdlvrdelekp
subfamily_KAPP-like_pd Subfamily KAPP-like 44-316 1.3e-29 96.1 In-house 10-266 (266) alignment 
Range on Protein: 44-316
Range on HMM: 10-266/266.0
ADMQDTHIMlpKFDLGTEKS--FLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKfsdfpTLTKSLKQTFTESYKAVDDGFLAIAKQNKPIWKDGT
  |.| ..   .. |. ||     |. ..||.||||||  ||.  .  . | ....| .     |  .   .   .  | ... |  . .. |    .|.
temedvsla..iypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllks.....tkqddGGdniydqskllenafkevdaklkdfeyeGa

TATTMIILN----NVIYVANIGDSRAVVARKKEDgsfapVCLTVDHDPMSHDERMRIQKAGAVVKDG--RINGVIeVSRSIGDLPFKS--LGIISTPDLK
|||  .. .      . |||.||| | ..|  |      . |. ||     .|. ||.. |  . |.  ||||.. |||..||   |   .|.||.| . 
tatlalvwsdGqqrylqvanvGdssaflsrGnes.....lelskdhkakdpeekqrikddGitlsdnqtrinGla.vsralGdhfikelniGlisepyvs

-KLTLTKNDLFAIIACDGLWKSFSNLEAVsfavEQLEAAKktDiEQEPNESREAAELRVvaeklAaeAVRRKCGDNVSVIIVKL
 ...||  | | |.| ||||   |  .|.    |....    | .|. ...  .. |..     |      |. ||||||.|||
nrilltpfdkflivasdGlwdvisGkdai....ekvksly..d.qqatedkmassllet.....a..iqsikakdnvsvivvkl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 44-316 2.8e-27 88.3 In-house 9-276 (276) alignment 
Range on Protein: 44-316
Range on HMM: 9-276/276.0
ADMQDTHIMlpKFDLGTEKS--FLSRASFFAIFDGHAGPRAAEHCQSQMGKTVkEKLAKFSDFpTLTK--SLKQTFTESYKAVDDGFLAIAKQNKPIWKD
  |.| ..   .. |. ||     |. ..||.||||||  ||.  .  . | . ||| | ... .|||     .   .  | . | |  . .. |    .
temedvsla..iyplldekdlsncsnialfavfdGhaGkGaadaakklfpkel.ekllksgny.sltkqddGGdniydqskllldlfkevdaklkdfeye

GTTATTMIILNNV----------IYVANIGDSRAVVARKKEDgsfapVCLTVDHDPMSHDERMRIQKAGAVVKDG--RINGVIeVSRSIGDLPFKS--LG
|.|||  .. ..           . |||.||| | ..|  |      . |. ||     .|. ||.. |  . |.  ||||.. |||..||   |   .|
GatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGnes.....lelskdhkatdpeekqrikddGitlsdnqtrinGla.vsralGdhfikelniG

IISTPDLK-KLTLTKNDLFAIIACDGLWKSFSNLEAVsfavEQLEAAKktDiEQEPNESREAAELRVvaeklAaeAVRRKCGDNVSVIIVKL
.||.| .  ...||  | | |.| ||||   |  .|.    |....    | .|. ...  .. |..     |      |. ||||||.|||
lisepyvsnrilltpfdkflivasdGlwdvisGkdai....ekvksly..d.qqatedkmassllet.....a..iqsikakdnvsvivvkl
subfamily_PP2D1_pd Subfamily PP2D1 44-131 7.2e-09 27.9 In-house 15-103 (492) alignment 
Range on Protein: 44-131
Range on HMM: 15-103/492.0
ADMQDTHIMLPKFDLGTEKsflsraSFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPTLTKSLKQT-------FTESYKAVDDGFLAIAK
..|.|.. .  .|   ...      .||.|.||. |  ||| . ... . . |.|.|. .  .|| . ..        . . . ...| . || |
skmeDkrtlqdyfgndvns......cFfgiyDGynGataAeiaakelhevlleelekvdervslttavnlidnndltdyelerasrsdsirailk
subfamily_PDP_pd Subfamily PDP 63-113 8.3e-06 18.1 In-house 20-70 (398) alignment 
Range on Protein: 63-113
Range on HMM: 20-70/398.0
SFLSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPTLTKSLKQ
.  |.. .|..||||.|  .||. . .. | |  .| | ..  . .| |..
llesngvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekales
subfamily_PHLPP_pd Subfamily PHLPP 67-273 1.1e-14 46.9 In-house 26-224 (246) alignment 
Range on Protein: 67-273
Range on HMM: 26-224/246.0
RASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDfptLTKSLKQTFTESYKAVDD-G-FLAIAKQNKPIWKDGTTATTMiilnNVIYVANIGDSRAV
. . . .|||..    ..  |  | . .||.. | ..    .. .|.|.  . . .   |  |  |     | .|    ..      .. ||..|   ||
vealyGlfdGdrneelssllqrlmkdvlkeevqkdkn...eeeymkntllvaqrklGeaGeklgsaallilirhdkvdPaks....fsLevAsvGtlqav

VARKKEdgsfaPVCLTvDHDPMSHDERMRIQKAGAVV-KDGRINGVIEVSRSIGDLpFKSLGIISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSF
..|...     .. |.  .. ...||  ||..| |..  |..|||||| .| .| . |    .. .| .....||..| . |.  . ||...|  |||. 
liRngk.....klrls.ksyviekdelkrikeakaiitednkingviestrllGyt.flfPvvlPkphvrevlLteqdellivGnkalWevlsideavea

A---VEQLEAAKK
     . | ||||
vrkeedplvaAkk
Subfamily Dicty-PPM1L-like 68-317 1.3e-17 56.6 In-house 37-304 (305) alignment 
Range on Protein: 68-317
Range on HMM: 37-304/305.0
ASFFAIFDGHAGPRAAEHCQSQM----GKTVKEKLAKFSDF-PTLTKSLKQTFTESYKAVDDGFLAIAKQNKPiwKDGTTA----TTMIILNNVIYVANI
 |.| .|||| | .|||. . ..     | |||  . .|       ..  ..  ... . |  .|. |. .    | |||     ...|. .. . |.. 
lslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnk..kaGttlngssasvilerertivsta

GDSRAVVARKK--EDGSFA--PVCLTVD------------HDPMSHDERMRIQKAG-AVVKDGRI--NGVIEVSRSIGDLPFKSLgIISTPDLKKLTLTK
.|. .|..     |  | .  |. . .|            .. . ...|.||. .. |... |..  |.....|||.||   | | .|  .| . | ..|
sdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellvnrllkksrskGdknlkel.viPnndspllvvak

-NDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKTD-IEQEPNESReaaelRVVAEklaaEAVRRKCGDNVSVIIVKLE
 || | ..| ||||. .|. . | .  | |.  ..   || ..||       ||..|    |||.|  |||. ..|.||.
anDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneis.....rvive....eavkrgsgDnitlviiklk
subfamily_PPM1H_pd Subfamily PPM1H 68-121 3.3e-07 22.4 In-house 62-115 (404) alignment 
Range on Protein: 68-121
Range on HMM: 62-115/404.0
ASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPTLTKSLKQTFTESYKA
  .|..||||||. ||  .  .. |..|||| .  .. . ... ....||. . 
layfglfDGhaGsgaalvaskllhkhlkekledvlellleksaeeeenteessk
subfamily_PPM1K_pd Subfamily PPM1K 69-268 2.8e-35 114.7 In-house 32-228 (263) alignment 
Range on Protein: 69-268
Range on HMM: 32-228/263.0
SFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDfptLTKSLKQTFTESYKAVDDgFLAIAKQNKPIWKDGTTATTMIILNN-VIYVANIGDSRAVVAR
 ..|.||||||. ||... ... |..|. | |  |   | . ||..| |  |..   .|     ..   . |||||  .. .   . .|..|||||.. |
lyvavfdGhaGsaaadfvhdklekilkrllekekd...leivlknafeeldkklkr.ylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcr

KKEdgsfaPVCLTVDHDPMSHDERMRIQKAGAVVK-----DGRINGVIEVSRSIGDLPFKSLGIISTPDLKKLTL-TKNDLFAIIACDGLWKSFSNLEaV
. .     . .|| ||||  ..|. ||..||  |.       ..||.. ..||.||| .|. |.|.||. |.| .  ..| | ..  ||.    .. | .
nGk.....akkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqe.l

SFAVEQL
.. |.. 
cdlvrlc
PP2C_SIG_SM00331 69-316 4.2e-13 42.4 In-house 31-217 (217) alignment 
Range on Protein: 69-316
Range on HMM: 31-217/217.0
SFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDFPTLTKSLKQTFTESykavddgflaiakqnKPIWKDGTTATTMII--LNNVIYVANIGDSRAVVA
 .....||. .  ||. . ||. . ..| | . ...... | | . . |                |     ..|.. ...   .. ...||.|||| .. 
lllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee...............keekgmfaTlllalydfssgklsyanaGdsrpyll

RkkEDGSFAPVCLtvdhdpmshdermriqkagavvkdgringvievsrsigdLPFKSLGIISTPD--LKKLTLTKNDLFaIIACDGLWKSFSNLEavsFA
|  ... . ..                                          . . ||......   ..|.| | ||. ... |||.   |  .   ||
r..dgklveilkd.......................................vegaplGlepevsvdirelelekgdll.llytDGltearsekg...fa

VEQLEAAKKTDIeqepneSREAAELRV-VAEKLAAEAVRRKCGDNVSVIIVKL
 |.|| . ..        . ||.||     |.| ..| ...  |...|..||.
eerleeiledlv......dseaqelaqkiveellelakgsngeDdiTvvvvkv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 70-232 1.6e-16 53.7 In-house 22-196 (292) alignment 
Range on Protein: 70-232
Range on HMM: 22-196/292.0
F-FAIFDGHA--GPRAAEHCQSQMGKTVKEKLAKFSDfptLTKSLKQTFTeSYKAVDDGFLAIAKQnkpiwKDGTTATTMIILNN-VIYVANIGDSRAVV
|  |..|||   | . |.  ...... . |   .  .   |...| .    .  |  |   . |..     . .|...  .. ..  ...||.|||||..
flaavldGhGvnGdkvaqlaedtlevelleltrqlqe...lsealllril.diaakldkltidare.....sattavvcarvrddralilanvGdsrall

ARKKEDGSFAPVCLTVDHDPMSHDERMRIQKAGAVVK-----------DGRI------NGVIEVSRSIGDLPFKSLGIISTPDL
 |      . .. |. || |   ||| ||..||  |.             |.      .| . .||..||. ..  |... |.|
grclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePel
subfamily_PPM1G_pd Subfamily PPM1G 133-281 1.7e-34 112.7 In-house 290-436 (473) alignment 
Range on Protein: 133-281
Range on HMM: 290-436/473.0
NKPIWKDGTTATTMIILNNVIYVANIGDSRAVVARKkedgsFAPVCLTVDHDPMSHDERMRIQKAGAVVK-DGRINGVIEVSRSIGDLPFK--------S
..|  . ||||. ... .. ..|||.||||.|..|.        . | .|| |  . |. ||.|||  |. |||.|| . .|| .||  .|         
eepGedsGttAvvaLlkekklivAnaGDsRcvlsrn.....GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplke

LGIISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKTdieqepN
  |   ||.|.||||..| | ..||||.| . .  | | |  ..|.  ...       
qmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees......v
subfamily_PPM1H_pd Subfamily PPM1H 137-197 1.6e-09 30.0 In-house 160-213 (404) alignment 
Range on Protein: 137-197
Range on HMM: 160-213/404.0
WKDGTTATTMIILNNVIYVANIGDSRAVVARKKEDgsfapVCLTVDHDPMShdERMRIQKA
 | | ||   ..|.. .|||| |||||.. ||.|      . |  |. | .  || |.|. 
ikGGCtalvalvllgklYvanaGDsRailvrkdei.....iplsadftPet..eRqRlqel
subfamily_TAB1_pd Subfamily TAB1 138-223 7.4e-15 47.6 In-house 128-214 (333) alignment 
Range on Protein: 138-223
Range on HMM: 128-214/333.0
KDGTTATTMIILNNVIYVANIGDSRAVVARKKEdgSFAPVCLTVDHDPMSHDERMRIQKAGA---VVKDGRINGVIEVSRSIGDLPFKS
..||||   .|.|| .||||.|||||.. ..||  |   . | |||.   .|| .|... |     .|  .. |  |  |||||.  | 
sgGttAvvalifnnkLyVaNvGdsrAllvkrke..sekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkk
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 139-259 7e-08 24.0 In-house 134-273 (317) alignment 
Range on Protein: 139-259
Range on HMM: 134-273/317.0
DGTTATTMIILNNV-IYVANIGDSRAVVARKK------EDGsFAPVCLTVDHDPMSHDERMRIQ----KAGAVVKDGRING--------VIEVSRSIGDL
 ||||.  ...... . ||| ||. |.|. ..       || .    |.| |.  |..|| |..    .|. | .|| .           . ...|.|  
fGttavvavvvdethvvvanaGdaaalvllrdqaghedrdG.lsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhk

PFKSLGIISTPDLKKLTLTKNDLFAIIAC-DGLWKSFSNLE
 .|  |.|  |. .  .|  .. ||.... ||.   ...|.
llkraGviadPevrsrvldvdevfavvvvsdGitdelkrld
subfamily_PDP_pd Subfamily PDP 140-222 9.5e-14 44.3 In-house 153-241 (398) alignment 
Range on Protein: 140-222
Range on HMM: 153-241/398.0
GTTATTMIILNNVIYVANIGDSRAVVARKKEDGSFAPVCLTVDHDPMSHDERMRIQKA------GAVVKDGRINGVIEVSRSIGDLPFK
|..|..  | .. ..|||.||.|||.....|.||.  | |. |.   ...|  ||.|.       .|...||. | .  .|  ||. .|
GacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryK
subfamily_PP2D1_pd Subfamily PP2D1 147-281 7.4e-22 70.7 In-house 184-320 (492) alignment 
Range on Protein: 147-281
Range on HMM: 184-320/492.0
IILNNVIYVANIGDSRAVVARKkedGSFapVCLTVDHDPMSHDERMRIQKAGAVV----KDGRINGVIEVSRSI---GDLPFKSlGIISTPDLKKLTLTK
 .   |.|.||.|. .||. |.   |.   ..|| .|.|  . || |..|||.||    | |..||.... | .   ||.  |.  .|  | ..  .|..
leelgvlyianaGnvqAvLcre...Gka..iiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkk.svipePkttsvklde

NDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAK-KTDIEQEPN
.. | ..|  |||. .|. | .| . . |.  | ..  |. |.
aaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvpd
subfamily_PPM1D_pd Subfamily PPM1D 211-317 2.8e-09 29.5 In-house 202-308 (309) alignment 
Range on Protein: 211-317
Range on HMM: 202-308/309.0
EVSRSIGDLP----FKSLGIIS-TPDLKKLTLTKNDL-FAIIACDGLWKSFSNLEAVSFAVEQlEAAKKTDIEQEpnesrEAAELRVVAEKLAAEAVRRK
 |.||.|||     ..   ..|  ||.|. ||. |.  | |.| ||||.  .  .|||.  .. |. |..  ||.     .    ..| | |   . .. 
avaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvveke.eekkelkeeqs.....rsvakalvkealqrwrskkl

CGDNVSVIIVKLE
  ||||||.| ||
raDnvsvivvile
subfamily_PDP_pd Subfamily PDP 227-286 1.3e-07 24.0 In-house 271-331 (398) alignment 
Range on Protein: 227-286
Range on HMM: 271-331/398.0
ISTPDLKKLTLTKNDLFAIIACDGLWKSFSNLEAVSFAVEQLEAAKKT-DIEQEPNESREA
...|.. .  |..|| | ..| |||| ..|| |.||  .| |. .|.. ....|...    
taePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlk
PPM_PTC7_motif 245-309 5.5e-08 26.2 In-house 1-51 (51) alignment 
Range on Protein: 245-309
Range on HMM: 1-51/51.0
IIACDGLWKSFSNLEAVSFAVEQLEAAKKtdieqepnesreaaELRVVAEKLAAEAVRRKCGDNV
|.|.||||  .|. |||... .||.. ..              ..  .||||. ||. | . ||.
iLAsDGLWDvlsdqeavdlvrdqlskkgl..............spqeaAeklvdealargseDni