Gene F40E3.5 in Caenorhabditis elegans

Synonym: CELE_F40E3.5, F40E3.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP080_AA protein Get Run
CeleP080_AA_21-328 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049330 Metallo-dependent phosphatases 22-319 1.6e-40 132.4 In-house 4-293 (309) alignment 
Range on Protein: 22-319
Range on HMM: 4-293/309.0
PDKIDYVKLISKIWTYIREYTPDGPRpqFYPEVLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKVPPeQTYVMLGCYLGRGFAQ
 |......|| .......|..  ...  .  |.|..||.| .|.||.  ........ |..| . |  | .. |. ... .|. ...|.|| . .||   
ldpllllelilslldllielllklkl..lseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpds

IECLVFLLAYKILHPEKVVLLKGHHEESISIEMLKVKEWLMARGierDVDLEECMIEMKRACSmmsAAAVIDSKILCMPGGPGPTIreKGLQKLVGLKKG
.|.| .|||.|.|.|..|.|| | ||  .   ... .......    ...| | .... |..     ||||..||||. ||. | .  . |. .  |.. 
levlllllalkllypdnvfllrGNHElrllnglygfgdetlrky...gaelweefldwlrslp...laaviggkilcvHgGlspdl..llldqirelerp

VQAIADkKLLMEASWS-----VLLLDDAQKDMHgmPFFTPQQATDFCKANNLKCIVRGRQMVDEGYLNKP-REVVTLISAVAYLDNFRNHAAVLQVDNDK
..  .|  ||..  ||     .  . . . ...   .|...   .|.| |.|..|.|| ..|..|||  . ....|. ||  |.....|..|||..|.|.
leipld.gllcdllwsdplpiregfapnprglg..vvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedl

GKVI
  ..
visf
0045823 Metallo-dependent phosphatases 26-328 1.3e-45 149.1 In-house 22-328 (473) alignment 
Range on Protein: 26-328
Range on HMM: 22-328/473.0
DYVKLISKIWTYIREYtpdGPRPQFYPEVLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKVPPeQTYVMLGCYLGRGFAQIECL
 . . .. .  .|. .      ... .|.|.|||.. .|.||.  ........ |..| . |  | .. |. ...  |. ...|.|| . .||   .|.|
fillglldldlliehl...kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppe.drlvflGDlvDrGpdslevl

VFLLAYKILHPEKVVLLKGHHEESISIEMLKVKEWLMARGierDVDLEECMIEMkraCSMMSAAAVIDSKILCMPGGPGPTIreKGLQKLVGLKKgVQAI
 .|||.||..|..|.|| | ||. .   ..  .......    ..|| | ..|    .. .  ||||..|||.. ||. | .  . |. .. ... .. |
elllalkikypgnvfllrGNHElrllnglygfgdetleky...gedlyeeflew...lrslPlaaviggkilfvHGGlspdl..plldqireier.plei

ADKKLLMEASWSVLlLDDAQKDMHGMPF-----------FTPQQATDFCKANNLKCIVRGRQMVDEGYL-NKPRE------VVTLISAVAYLDNFRNHAA
 | .||..  ||    .| .... ...|           |.|. . .|.| |.|..|||| ..|.|||     .       ..|. ||  |.... | ||
pddgllldllwsdP.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaA

VLQVDNDKGKVIRYKMEEGEQ
||..|.|. ..| ... . ..
vlvidedlisfiqfdpsphpl
0053225 Metallo-dependent phosphatases 48-314 1.7e-37 122.6 In-house 20-280 (293) alignment 
Range on Protein: 48-314
Range on HMM: 20-280/293.0
PQFYPEVLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKVPPeQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHE
...  |.|..||.. .|.||.  ........ ...| . |  | .. |. ... .|.  ..|.|| . .||   .|.| .|||.|.|.|..|||| | ||
kllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHE

ESISIEML-KVKEWLMARGierdvdLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIRekGLQKLVGLKKgVQAIADKKLLMEASWS--VLLLDDA
. .   .. . .|.|.  |       .|   |. .  . .  ||.|..|||.. ||. | .    |. .  ... .. | . .||..  ||   |  . .
lmllnglygfgdetlrkyg......aaelwdelldwlrslplaaliggkilfvHgGlspdls..lldqireinr.plriplegllldllwsdpdlwsgwl

QKDMHGMPFFTPQQATDFCKANNLKCIVRGRQMVDEGYLNK-PREVVTLISAVAYLDNFRNHAAVLQVDND
..      .| ..   .|.|.|.|..|.|| |.|..|||    ...||. || .||. ..|..||| .|..
psyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeg
subfamily_PPG1_pd Subfamily PPG1 49-315 1.2e-19 63.7 In-house 12-286 (300) alignment 
Range on Protein: 49-315
Range on HMM: 12-286/300.0
QFYPEV-LKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKVPpEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHE
.. ||| .|.| .|  |.| ..  |...  |  . | |.|.   .. .. .  .|| .  |..|| |. ||.  .| ...|.. |. .| .. ||.| ||
ellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvp.dtnylflgdyvdrglysvetisllivlklrypsritllrgnhe

ESISIEMLKV-KEWLMARGIErdVDLEECMIEMkraCSMMSAAAVIDSKILCMPGGPGPTIREKGLQKLVGLkkgVQAIADKKLLMEASWSVLL------
     ..     | |   | .    . . . |.      .. ||.|| .| |. ||  |...     |..      . . ..  | .  ||         
srqitqvygfyteclrkyggn..srvwkyltei...fdylvlaaiideeiycvhgglspsvlsidqikvldr...frevpnegaladllwsdpeennnpt

LDDAQKD-------MHGMPF-FTPQQATDFCKANNLKCIVRGRQMVDEGYLNKP-REVVTLISAVAYLDNFRNHAAVLQVDNDK
||  ...         |  . .  . .  | . |... |.|  |.. |||       . |. ||  |     |.|..|.. . .
ldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekd
PP2Ac_SM00156 51-316 3.3e-78 255.5 In-house 2-261 (271) alignment 
Range on Protein: 51-316
Range on HMM: 2-261/271.0
YPEVLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKkVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESI
..| ...||....|.|||....|.|..| ...|...|. |....|..||. .|||..||.||.|. || ..||....|.|.|||.|||||||.|.||.| 
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsss

SIemlkvkewlMARGIERDVDLEE---CMIEMKRACSMMSAAAVIDSKILCMPGGPGPtiREKGLQKLVGLKKgVQAIADKKLLMEASWSVL--LLDDAQ
.          ...|.|..|. ..   .. ....|.|....||..|||||||.||  |  ... |...  ||. |.......||..  ||      ...|
vn.........kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp..eleslddirklkr.vkekpeegllidllwsdpeqkekgfq

KDMHGMPF-FTPQQATDFCKANNLKCIVRGRQMVDEGYLNKPR-EVVTLISAVAYLDNFRNHAAVLQVDNDKG
....|. . |.......|.|.||||.|.|....||||| .. . ..||..||..|.|.|.|.||||.|...  
pskrglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlk
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 52-313 1e-23 77.2 In-house 5-262 (284) alignment 
Range on Protein: 52-313
Range on HMM: 5-262/284.0
PEVLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSlAKKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESIS
|| .. || ......... |...|  |  | | ..|.   .. |.   . .|    |..|| |. ||   .| ...|.|||.. |.....|.| || |. 
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfd.kngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsli

IemlkvKEWLMARGIERDVDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIREkgLQKLVGLKKGVQAIADKKLLMEASWSVL--LLDDAQKDMH
      | . .    .|  .    .  ..   | |  .|..  .|||| ||    ...  . .|  .|. ..    . | ..  ||    .    . . .
n.....kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqn..vsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsr

GMPFFTP-QQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQVDN
|. .    .    .    ..  .|| .|.|..|| .   | .||..||  |  .| | |||. |..
gvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnk
PPP_3 53-316 5.9e-39 126.7 In-house 5-263 (271) alignment 
Range on Protein: 53-316
Range on HMM: 5-263/271.0
EVLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKvPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISI
..||.|..|  |.|.. ...|... | ...| . |  | .. |.. ... .||..|. || |  ||   .|.|..|||.||..|..|.||.| ||..   
nelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggp.spetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqin

EMLKVKEWLMargieRDVDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIREKGLQKLvgLKKGVQAIaDKKLLMEASWSVLLL--DDAQKDMHG
..   |. ..     . .  ..   ....  .... ||.||.|.|.. ||  |.|..   .|   |..  .   ....|.. ..|      .  ...  |
kvYgFkkevl.....kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikk..lerkievp.eegklldlllssdpekeeglenskrG

M-PFFTPQQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQVDNDKG
.  .|.|. ...|...|.||.|.|  ....||| . . ..|||. ||  |.... | .|.|...... 
agllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealt
subfamily_PPP1C_pd Subfamily PPP1C 54-315 3e-40 131.2 In-house 14-269 (282) alignment 
Range on Protein: 54-315
Range on HMM: 14-269/282.0
VLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLaKKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIE
 ...||.|. |.|... ...... |  |.| ..|.   .. |..  . .|||..|..|| |  ||   .| .|.|||||| .||.. ||.| ||..   .
eieallkkareillsqpilleleaPvkivgdihGqyadllrlfet.sgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinr

MLKVKEWLMARGIERdvdleeCMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIREkgLQKLVGLKKGVqAIADKKLLMEASWSVLLL--DDAQKDMHGM
.   ..    |   .          .. . ...  ||..|.||||. ||  |....  |...  ... .  ...| ||..  ||       . ...  |.
iyGfydeckrrysik......lWktftdvfnclPlaalvdekilcvhGGlspelks..leqirkiqrPl.evpekgllcdllWsdpdkevlgwsendrGv

PF-FTPQQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQVDNDK
 | | ... ..|.. |.|. |||. |.|..|| . . |..||. ||  |...| |..|||.||...
sftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeel
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 54-314 1.8e-36 118.7 In-house 28-283 (298) alignment 
Range on Protein: 54-314
Range on HMM: 28-283/298.0
VLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLaKKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIE
 ..||.... ...|. ...|.| .|  . | ..|    .. |..   . ||.. |..|| |. ||  ..| .|.|||||. .|....||.| || ..  .
dveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdk.agfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainr

MLKVKEWLMARgierdVDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIRekGLQKLVGLKKGVQAiADKKLLMEASWSV--LLLDDAQKDMHGM
.   .|    |      .  .   |.. . ...  .|.| ..|||| ||  ....   |..|  ||. ...  .. | ..  |.     . . ...  |.
vyGfyeeckrr.....ykslrlyaefqdvfnalpltaliggrilcmhGGlskklk..sldqlrelkrpfds.keeslaidllwadpenavkgwaensrGv

P-FFTPQQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQVDND
   |  ..  |...  ..  .||. |.| .|| .   . .||. ||  |...| | |||..||..
svvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdek
subfamily_PPP3C_pd Subfamily PPP3C 54-324 1.6e-33 109.1 In-house 45-322 (452) alignment 
Range on Protein: 54-324
Range on HMM: 45-322/452.0
VLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKvPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIE
.  |........||... ...|  | .. | ..|    .. |.... . | ...|..|| |. ||   |||...|.| || .|... ||.| ||     |
aalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGd.PastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlte

MLKVKEWLMARGIErDVdLEECMiemkRACSMMSAAAVIDSKILCMPGGPGPTIREkgLQKLVGLKKgVQAIADKKLLMEASWSVLLLDDAQ--------
 .. || .  .  | .|  ..||    ..  ..  ||... . ||. || .| |..  |...  |..  . .  . .| .  ||  | |  .        
yftfkeeckikyse.ev.ydacm....esfdslPlaallnqqflcvhGGlspeiks..lddikkldr.fkeppasGplcdllWsdPledygeekteekfv

-KDMHGMP-FFTPQQATDFCKANNLKCIVRGRQMVDEGYLNKPR-------EVVTLISAVAYLDNFRNHAAVLQVDNDKGKVIRYKME
  .. |   |.. . ...| ..|.|  |.|  .  |.|| .. .        ..|| ||  ||| . | ||||...|.. ....... 
pnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvmnirqfnss
PPP_1 54-310 2.9e-32 105.0 In-house 5-263 (264) alignment 
Range on Protein: 54-310
Range on HMM: 5-263/264.0
VLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKkVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIE
.|..|..|. |.|...|....|. .  . | . |. | .. |.  ..  .||..|. || |  ||   .|.|..|||.|. .|... ||.| || .   .
elaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvgg.pspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtk

MLKVKEWLMargieRDVDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIREKGLQKLVGLKKGVQAIADKKLLMEASWSVLLLDDAQKD------
.   |. ..     . .  .|    .. .  ... ||.|| |||.. ||  |...    .. .  |. | . .  . |.|.  . || || ...      
vygFkkEvl.....kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavans

MHGMP-FFTPQQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQ
. |.  .|... ...|...||||.|.|  ....||| . | |.|||..||  | ... |..|...
iRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_PPP6C_pd Subfamily PPP6C 54-319 6e-30 97.4 In-house 19-278 (290) alignment 
Range on Protein: 54-319
Range on HMM: 19-278/290.0
VLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKVPpEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIE
 |||| .. ...| ..  |. |. |  . | ..|.   .  |.  . .|| ...||.|| .. ||.  .| .  ||. |. .|....||.| ||     .
dlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvp.dtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitq

MLKVKEWLMARgierdVDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIREkgLQKLVGLKKGvQAIADKKLLMEASWSVL-LLDDAQKDMHGMP
.    .  . .         ..   . .   ... ||.|| ..||. ||  | ..   |...  ...  | |. |  . .  ||    ... .    |  
vygfydeclnk.....ygnanawkyctkvfdlltiaaiideqvlcvhGglspdvkt..ldqirviera.qeiphkgafcdlvwsdpedvetwavsprgag

F-FTPQQATDFCKANNLKCIVRGRQMVDEGYLNK-PREVVTLISAVAYLDNFRNHAAVLQVDNDKGKVI
. |  . ...|.. |||| |.|  |.|.||.  .   ..||. ||  |     | |..|...... .  
ylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeerea
subfamily_PPP2C_pd Subfamily PPP2C 54-316 8.3e-28 90.4 In-house 21-277 (290) alignment 
Range on Protein: 54-316
Range on HMM: 21-277/290.0
VLKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKVPpEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIE
 .|.| .|  |.|.... | .|  |  . | |.|.   .. |. .  |.| .  |..|| |. ||.  .|.. .| | |. ..|....|.| ||     .
evkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggksp.dtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitq

MLKVKEWLMARGIerdvdLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIreKGLQKLVGLKKgVQAIADKKLLMEASWSVLllDDA---QKDMHG
.    .  . .         .    .     ... .|..|..|.|. ||  |.|  . |.|.  |.. .| . ..  | .  ||    ||    .    |
vygfydeclrkyg.....nanvwkyftdlfdylpltalvdeqifclhgglspsi..dtldkiraldr.lqevphegplcdllwsdp..ddrggwgisprg

MPFF-TPQQATDFCKANNLKCIVRGRQMVDEGYL-NKPREVVTLISAVAYLDNFRNHAAVLQVDNDKG
  .    . . .| |.|.|. |.|  |.| |||     |.|||. ||  |     |.||.|..|..  
agytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklk
subfamily_PPP4C_pd Subfamily PPP4C 55-317 2.5e-31 101.9 In-house 21-277 (288) alignment 
Range on Protein: 55-317
Range on HMM: 21-277/288.0
LKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKVPpEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIEM
.|.| .|. |.| ..  | .|  | .. | ..|.   .. |. .. .|| |. |..|| .. |||  .|....|||.|. .|....|..| ||     ..
vkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvp.etnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqv

LKVKEWLMARGIERDVdLEECMiemkRACSMMSAAAVIDSKILCMPGGPGPTIREkgLQKLVGLKKgVQAIADKKLLMEASWSVLLLDDA-QKDMHGMP-
    .  . .  . .|  . |.    .   ..| ||.|| ||.|. ||  | |..  |...  . .  | . ..  | .  ||     ..      |   
ygfydeclrkygsanv.wryct....evfdylslaaiidgkifcvhgglspsist..ldeirsidr.kqevphegplcdllwsdpedaegwavsprgagy

FFTPQQATDFCKANNLKCIVRGRQMVDEGYLNKP-REVVTLISAVAYLDNFRNHAAVLQVDNDKGK
.|  . ...|..||... |.|  |.| |||  .  ..|.|. ||  |     | ||.|..|..  |
lfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 55-313 4.8e-30 97.5 In-house 15-270 (287) alignment 
Range on Protein: 55-313
Range on HMM: 15-270/287.0
LKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSlAKKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIEM
. ..|.|  |.|.  . ...|. | .|.| ..|. |... ..  |   .|.  |..|| |. ||   .|  ..|...||. |.|| ||.| ||     ..
ilevlekieeileplpalleveapitivGdihGqlddllrifn.avGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinkl

LKVKEWLMARGIerdvdlEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIreKGLQKLVGLKKGVQAI-ADKKLLMEASWSVLLLDDAQKDMHGM--
   || |. .        |.   . .   | ..  | .. .|||| ||  | .  | |..| .|||  . .  |. | ..  |.    |.   ..  .  
yGfkeelkrkrq......erlykqfndvfselplcarvskrilcmhGGispkl..ksldslkalkkpttplacdeglqvdllwadpekdaktfelnkira

--PFFTPQQATDFCKANNLKCIVRGRQMVDEGYL-NKPREVVTLISAVAYLDNFRNHAAVLQVDN
    |  ..  |..|  ... |||  ....|||     . .||. ||  |  .  | .||..|..
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 55-313 4.5e-26 84.5 In-house 21-277 (290) alignment 
Range on Protein: 55-313
Range on HMM: 21-277/290.0
LKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSlAKKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIEM
. ..|.|  |.|.    ...|  | ||.| ..|. |...  .  |   ||.  ...|| |. ||   .|  ..|. |||....|| ||.| ||      .
ileilekieeileplpalleveapivivgdihgqldallryfd.avgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrl

LKVKEWLMARgieRDVDLEEcmiEMKRACSMMSAAAVIDSKILCMPGGPGPTIRekGLQKLVGLKKG-VQAIADKKLLMEASWSVLLLDDA----QKDMH
   || |. .   |.  |      ..   . .|  | .. ||||| ||  . |     . | .|||  |.   |. | ..  |.    | .     . . 
ygfkeelark...rgsrlwk...qyqdvfaelslcarvgrkilcmhggisqkie..sweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqr

GMP-FFTPQQATDFCKANNLKCIVRGRQMVDEGYL-NKPREVVTLISAVAYLDNFRNHAAVLQVDN
..   |  .   |..|   |. |||  .. .||.  .  . .||..||  |  |  |  |...| .
aisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvse
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 55-313 1.1e-24 80.2 In-house 28-283 (297) alignment 
Range on Protein: 55-313
Range on HMM: 28-283/297.0
LKKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAkKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIEM
. |||. . .|.|... .|.|  |  . | ..|.   .. |.      ||   |..|| |. ||   || .|.|||||.  | ...||.| ||  .  ..
vlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrg.gwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkv

LKVKEWLMARgierdVDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGP-TIREKGLQKLVGLKKGVQAiaDKKLLMEASWSV--LLLDDAQKDMHGM
  . |    |      .    .  ..     .  . .| .||||| ||  |   .|  |. |  ...  .    ..|. .  |.     |    .. .| 
ygfyeecqkr.....yqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg..kerlvadllwadpisglsgfmenqrga

-PFFTPQQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQVDN
   |  .   . |   .|  ..| .|.|..|| .   |..||..||  |  .| | ||.. .|.
gcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscde
subfamily_PPP7C_pd Subfamily PPP7C 55-202 2.1e-10 32.9 In-house 38-186 (383) alignment 
Range on Protein: 55-202
Range on HMM: 38-186/383.0
LKKLLQKSCEVLKQDEMVVKVTGP----AVIFGPVYGEGDSMISLMSLAKKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESI
. ..|... .|||| . . .|.        . | ..|. | .. ..       .|..||. | .. ||   .| |. |||. ...|..| | .| ||..|
vllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhi

SIE-MLKVKEwLMARGierDVDLEECMIEMKRACSMMSAAAVIDSKILCMPGG
       .|| .. .     |  .. .  ..   . .  |..||.||| . ||
lnlryGfike.vesky...kvhgkkilrlledvfawlplatlidekilivhGG
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 56-315 5.1e-30 97.7 In-house 12-290 (302) alignment 
Range on Protein: 56-315
Range on HMM: 12-290/302.0
KKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLA------KKVP----PEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGH
 .|...  | ||... ..... |  | | ..|. . .. ..         || .     .. .|.|| |. ||   |||. ...|.|.|.|.. .||.| 
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn

HEeSISIE-MLKVKEWLMARgIERdVDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIreKGLQKLVGLKKGVQAIADKKLLMEASWSVLLLDDA
|| . .|.   . .| |  | . .  |  |   ... . | |  ||.. .||||. ||  | .  . |...  .|. .. ...  |  .  ..  |  ..
he.tkainfaygfreelenr.lgk.kdgkeiwekfnevfsfmplaalvgekilcvhggispkl..esledikkikrplkevtedslaqdllfadpldvql

-----------QKDMHGMPF-FTPQQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQVDNDK
           .  . |. . |     .|.||  ||| |||. ||. ||. ..  . ..|. ||  |...  |. |||.|| . 
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 56-315 5.5e-30 97.6 In-house 13-291 (302) alignment 
Range on Protein: 56-315
Range on HMM: 13-291/302.0
KKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLA------KKVP----PEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGH
 .|...  | ||... ..... |  | | ..|. . .. ..         || .     .. .|.|| |. ||   |||. ...|.|.|.|.. .||.| 
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn

HEeSISIE-MLKVKEWLMARgIERdVDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIreKGLQKLVGLKKGVQAIADKKLLMEASWSVLLLDDA
|| . .|.   . .| |  | . .  |  |   ... . | |  ||.. .||||. ||  | .  . |...  .|. .. ...  |  .  ..  |  ..
he.tkainfaygfreelenr.lgk.kdgkeiwekfnevfsfmplaalvgekilcvhggispkl..esledikkikrplkevtedslaqdllfadpldvql

-----------QKDMHGMPF-FTPQQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQVDNDK
           .  . |. . |     .|.||  ||| |||. ||. ||. ..  . ..|. ||  |...  |. |||.|| . 
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 56-314 3.1e-29 95.3 In-house 14-272 (284) alignment 
Range on Protein: 56-314
Range on HMM: 14-272/284.0
KKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKK-----VPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEeSI
 .|  .. |.. .... ...  |  | | ..|. . ...|. |           |. |..|| |. ||   || ...|.|||.|.|.||.||.| || | 
ielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhe.sr

SIEMLKVkewLMARGIER-DVDLEECmieMKRACSMMSAAAVIDSKILCMPGGPGPTIREkgLQKLVGLKKGVQaIADKKLLMEASWS-----VLLLDDA
 ..|      ...    |  . | |.   .. |   |  .||...||.|| ||    . .  |..|  |.. .. |.|  .. . .|.     |   ...
pvnmqyg...fyleckkrysealyea...fqlafnamplcavvskkiicmhggisedlld..lkqldklerpid.ipdigviadltwadpeaevegykes

QKDMhgMPFFTPQQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQVDND
..       | ..   .|.|  .|. .||  |.| .|| .   |..||..|| .|  .. | ||||.||..
prga..gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdee
subfamily_PPPLV_pd Subfamily PPPLV 56-206 4.1e-16 52.1 In-house 3-153 (290) alignment 
Range on Protein: 56-206
Range on HMM: 3-153/290.0
KKLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKVPPE---QTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISI
  | ... ..| ..| ....  |. ..| ..|.   .| . .   .. ..    ....|| |. ||   .| . .||| |.| | ||.||.| ||     
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

EMLKVKEWLMARGierDVDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPT
| .. |   . .      .|||    .. .  ..  ||||| |..|. .|   .
esieykgegsfkf...gdsleevweafnnvfdalplaavidrkvfcvhagipra
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 57-314 7.4e-34 110.1 In-house 13-264 (280) alignment 
Range on Protein: 57-314
Range on HMM: 13-264/280.0
KLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAkKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEeSISI-EML
....|  ..|. .. .|.| .|  . | ..|.   .. |.. .   ||.| |..|| |. ||  |.| ...|||||. .|.. ..|.| ||  ||| .  
rviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarv.sfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhe.visinrky

KVKEWLMARgierdvDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIreKGLQKLVGLKKGVQAiADKKLLMEASWSVLL--LDDAQKDMHGMP-
  |.  . |        ..   |..    ..  .|..  .|||| ||  . .  . |..|  |..  ..  |. | |.  |.     .    ..  |.  
gfkdevkrr......yslalynefqelldslplvalvsgrilcmhgglsqkl..vslddlaelrrpfds.edeclamdllwadpenkvtgwaensrgvsv

FFTPQQATDFCKANNLKCIVRGRQMVDEGYL-NKPREVVTLISAVAYLDNFRNHAAVLQVDND
 |  ..  |...  ..  |.|| |.|..||     . .||..||  ||..| | ||||.||. 
ifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivder
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 57-316 7e-29 94.0 In-house 27-283 (307) alignment 
Range on Protein: 57-316
Range on HMM: 27-283/307.0
KLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKvPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIEMLK
... ..  ..  .  .| .  |.|. | ..|. . .| .. |  . |||  ||. | |. ||.  .||...|..||| .||..|||.|.|| .   .   
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgr.ppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkyg

VKEWLMArGIERdvDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIR--EKGLQKLVGLKKGVQAIADKKLLMEASWSVLLLDDAQKdMHGMPFF
. |  ..  | .    ||    ..|.   .  .|.| .||||| ||  |..   ..  ..   ... .. | .  |  .   ||.    . .   |. | 
fyeecvt.sipk..cgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassr.gsgftfg

TpQQATDFCKANNLKCIVRGRQMVDEGYL-NKPREVVTLISAVAYLDNFRNHAAVLQVDNDKG
| .   | ||   .. |.|  ||. .||     | ..|..||  | . ..|  .||.||.  |
t.nviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlg
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 57-314 3e-28 91.8 In-house 15-266 (281) alignment 
Range on Protein: 57-314
Range on HMM: 15-266/281.0
KLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKVpPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIEM-L
.....   .. ... .|..  | |. | . .. . .. |. |  .| ||. .|.|| |. ||   .|.|..|...|| .....|||.| || .    .  
nvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrv.peevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiyg

KVKEWLMARGIERDVDLEECMiemkracSMMSAAAVIDSKILCMPGGPGPTIREkgLQKLVGLKKGVQAIaDKKLLMEASWSVL--LLDDAQKDMHGMPF
  .|  .  |.|  .....|.         .  .| |. ..||| ||  | .    |..|    | .. . |. |...  |.       . .. . |. |
fyvecvtkyGeelwalfqrcf.......nrlpisaliakrvlcmhGGlsPelta..ldelrnrpkpirnl.drGlviDllwadpdnkveewkassrGssf

-FTPQQATDFCKANNLKCIVRGRQMVDEGYL-NKPREVVTLISAVAYLDNFRNHAAVLQVDND
 |  .   | ||  ..  |.|. |.| .||   . | ..|..|.  | . ..| ||||.||..
tfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdet
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 57-314 9.7e-27 87.0 In-house 31-283 (299) alignment 
Range on Protein: 57-314
Range on HMM: 31-283/299.0
KLLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAkKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESIsIEmlK
.| . . .|. ..  ...|  | .. | ..|.   .. ... | . ||.  ...|| |. ||  ..| ...||..|| .||.  .|.| ||    |.  .
tlcavaksvfasqaslleveapiivcgdihgqysdllrifdka.gfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpa.in..r

VKEwlMARGIERDVDLEECMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIREkgLQKLVGLKKGVQAiADKKLLMEASWSV--LLLDDAQKDMHGMPF-
|    .    ..          .. | ..|  . .| |.|||| ||  | ...  |..|  | .  .   .  | ..  |.     . | . .. |. . 
vyg..fyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqt..ldqlrdltrpqdp.pnpslgidllwadpdqsvkdwlanvrgvsyv

FTPQQATDFCKANNLKCIVRGRQMVDEGYL-NKPREVVTLISAVAYLDNFRNHAAVLQVDND
| ..  .| ..  ..  . |  |.|..||     . .||..||  |  .| | ||...||..
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvden
subfamily_PPP5C_pd Subfamily PPP5C 57-318 5.6e-24 77.7 In-house 41-301 (322) alignment 
Range on Protein: 57-318
Range on HMM: 41-301/322.0
KLLQKSCEVLKQDEMVVKVTGPA----VIFGPVYGEGDSMISLMSLAKKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISI
|.|... |.||.   .|..| .      . | ..|.   .. .. |  .. .|..|.. | .. ||   .|... ||..|.|.|... | .| || .   
killeakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmn

EMLKVKEWLMARGIERDVDLeecmieMKRACSMMSAAAVIDSKILCMPGGPgPTIREKGLQKLVGLKKGVQAIADkKLLMEASWSVLLLD-DAQKDMHGM
..   ..   |.  |. .||      ...  ...  | ||..|.| . ||  ..  .  |..|  ...  |   .  ||.|  ||        .. . |.
klyGfegevkakytekvadl......ftevfnwlPlahvinekvlvvhGGl.fsedgvtlddlrkidrnaqppee.gllvellwsdpqeanGrspskrGv

P-FFTPQQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQVDNDKGKV
   | |. .. |.| |||. |.|  .. .||| ...  ...|..||  | |.  |..|.... .|. |.
gvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlkl
subfamily_PPZ_pd Subfamily PPZ 58-313 1.9e-19 63.3 In-house 33-282 (300) alignment 
Range on Protein: 58-313
Range on HMM: 33-282/300.0
LLQKSCEVLKQDEMVVKVTGPAVIFGPVYGEGDSMISLMSLAkKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESisiEMLKV
. .|. |..  .  ..... .  | | |.|.   .. |.. .  .||   |..|| |. ||   .| ...||.||| .||...||.| || .   .. .|
icikarelflaqpallelspsvkivgdvhgqyadllrlftkc.gfppsanylflgdyvdrgkqsletillllcykikypenffllrgnheca...nvtrv

KEWLMARGIERDVDLEECMIEmkrACSMMSAAAVIDSKILCMPGGPGPTIREKGLQKLVglKKGvQAIADKKLLMEASWSVLLL--DDAQKDMHGMPFFT
  .        .. . . ...   .   .  ||..  ||.|. ||  | .      . |   .    . |  |. .  ||      .. . . .|. .  
ygfydeckrrcnikiwktfvd...tfntlplaaivagkifcvhgglspvlnsmdeirhv..vrp.tdvpdfglindllwsdptdssnewednergvsycy

PQQA-TDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQVDN
 . |   | .   .  ..| . .|..|| . . | .||..||  |  .| |  ||. | .
nkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvse
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 70-312 7e-20 64.6 In-house 26-262 (280) alignment 
Range on Protein: 70-312
Range on HMM: 26-262/280.0
EMVVKVTGPAVIFGPVYGEGDSMISLMSLAKKVPpEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIEML-KVKEWLMARGIER
  ...   |  . | .. . . |  |. |  .|| |.  ..|| |. ||   || |..|.. || . ... ||.| ||     ..     |     |.  
snlceaeapikvigdihaqyqdmnrlfdligrvp.eeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvgl

DVDLEECMIEMkracsmmSAAAVIDSKILCMPGGPGPTIREkgLQKLVGLKKGVQAIaDKKLLMEASWSVLLL--DDAQKDMHGMPFF-TPQQATDFCKA
  |.. |.  |         ...|  ..||| ||  | . .  |. .  . . .. . |. ||..  ||      .   . ..|. ..       . ||.
wwdfqscfnrm.......pmsgliskrvlcmhgglspelin..ldtirniprpcepl.drgllidllwsdptnkgegwfhsirgisymfgkgvveqacks

NNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDNFRNHAAVLQVD
 ..  |.|..|.|..|| .   | ..|..|   |  .| | |||. ..
leidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvcln
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 75-312 2.3e-18 59.8 In-house 5-243 (263) alignment 
Range on Protein: 75-312
Range on HMM: 5-243/263.0
VTGPAVIFGPVYGEGDSMISLMSLAKkVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIEMLKVKEWLMARgIERDVDLEE
.  |  | |  .|. . .. ..  .     .  |..|| |. ||   .| ...|.. |.  | |. ||.| ||     .   ..  |  | ..|.   | 
lqapinicgdthgqyndllrifnacg.aatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkr.fqreevyes

CMIEMKRACSMMSAAAVIDSKILCMPGGPGPTIreKGLQKLVGLKKGVQAIADKKLLMEASWSvllldDAQKDMHGM---------PFFTPQQATDFCKA
    ...  | |  .|..  .|||| ||  | .  | |. .  .   ...   . |  .  |.     | .|| .|.           |  ..  |.|| 
vynhfnqvfsymplcaivskrilcmhggisphl..kslddiraiplpletakthplacdllwa.....dpekdakgfepnkiraisnvfgkkevddlckr

NNLKCIVRGRQMVDEGYL-NKPREVVTLISAVAYLDNFRNHAAVLQVD
 ..  ||| .|.|. ||     | ..|..||  |  .. |.|||. |.
ldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvn
PPP_4 80-277 3.7e-25 82.1 In-house 2-196 (197) alignment 
Range on Protein: 80-277
Range on HMM: 2-196/197.0
VIFGPVYGEG-DSMISLMSLAKKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIEMLKVKEWLMARgierdvDLEECMIE
...| . |   | ...|. .. . ..|. || || |  ||   .|.|..|||.|.  |..||||.| ||..   .. . |. .. .      . .| . .
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek......hgkeilkk

MKRACSMMSAAAVIDSKILCMPGGPGPTIREkgLQKLVGLKKGVQAIADKKLLMEAS-WSVLL--LDDAQKDMHGM-PFFTPQQATDFCKANNLKCIVRG
...  .... ||.||.|.|.. ||  .....  |.|.  ... ..   ....... . ||      .  ..   |.  .|.|. ...|...||||.|.|.
lqdvfdllplaalidekvlvvhgglsdeles..ldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirs

RQM
 ..
hel
PPP_2 80-277 1.1e-23 77.0 In-house 2-197 (198) alignment 
Range on Protein: 80-277
Range on HMM: 2-197/198.0
VIFGPVYGEGDSMISLMSLAkKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIEMLKVKEWLMargieRDVDLEECMIEM
...| . |. | .. |.. . . .||..|. || |. ||   .|.|..|||.|. .|..|.||.| ||..   ..   |. ..     . .  .. . ..
tvcGDlHGqldDLlilfkng.lpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl.....kkkggkkvykkl

KRACSMMSAAAVIDSKILCMPGGPGPTIREKGLQKLVGLKK-GVQAIADKKLLMEASWSVLLLDD--AQKDMHGM-PFFTPQQATDFCKANNLKCIVRGR
..  .... ||.||.|.|.. ||  ..|..   .|    |.  ..  . ..||.| ..|    ..   ...  |.  .|.|. .......|.||.|.|  
qevfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaH

QM
..
ev
PPP_5_Dcr2 81-277 1.4e-22 73.6 In-house 3-198 (199) alignment 
Range on Protein: 81-277
Range on HMM: 3-198/199.0
IFGPVYG-EGDSMISLMSLAKKVPPEQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEESISIEMLKVKEWLMARGierdvDLEECMIEM
..| . |  .|... |.  . . ..|. || || |  ||  ..|.|..|||.|.. |..|.||.| ||..   |.  ...  . .      . .. .  .
vcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky.....hgkkiykil

KRACSMMSAAAVIDSKILCMPGGPGPTIREkgLQKLVGLKKGVQAIADKKLLMEAS-WSVLL--LDD-A-QK-DMHGMpFFTPQQATDFCKANNLKCIVR
..  .... ||.||.|.|.. ||  |.|..  ...|  ... ..   .|.  ..   ||      ..   ..   .|. .|.|. . .|.. ||||.|.|
sdvfdwlPlaalidekvlvvhgglspeiks..iellekierkieipeekgekadlllwsdprdaqegcklnseRGagl.lfgpdvtekfleknnlkliir

GRQM
. ..
shel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 105-314 3.5e-27 88.4 In-house 100-304 (317) alignment 
Range on Protein: 105-314
Range on HMM: 100-304/317.0
EQTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEeSISIEMLKvkEWLMARGIERDVDLEECMiemKRACSMMSAAAVIDSKILCMPGGPG
 . |..|| |. ||   || ...|.|.|.|.|.||.||.| || | ....     . .      .. | |..   . |  ..  .||...||||| ||  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhe.srpvntqy..Gfyrevkkrysaalyeaf...qlafnvlplcavvnkkilcmhGGis

PTIREkgLQKLVGLKKGVQaIADKKLLMEASWSV--LLLDDAQKDMHGMP-FFTPQQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLD
  . .  |..|  ||. .. |.|  .| . .|.      .  ..   |    | ..   .|.|  .|. .||. |.| .|| . . |..||. || .|  
eelld..lkqldklkrpld.ipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycG

NFRNHAAVLQVDND
.. | ||||.||..
qldniaavlsvdkk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 106-314 6.1e-20 64.6 In-house 120-323 (339) alignment 
Range on Protein: 106-314
Range on HMM: 120-323/339.0
QTYVMLGCYLGRGFAQIECLVFLLAYKILHPEKVVLLKGHHEeSISIEMlkVKEWLMARGIERDVDLEECMIEMKracSMMSAAAVIDSKILCMPGGPGP
. |..|| |. ||   .| ...| | |. .|... ||.| || | |..      .        | .| ||. .|     ..  .|||.  |.|| ||   
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhe.srsvnt..sygfyrevnyrydaqlyecfqnmf...nvfpfcavinntimcmhggise

TIreKGLQKLVGLKKGVQaIADKKLLMEASWSVLLLD-D-AQKDMHGMPF-FTPQQATDFCKANNLKCIVRGRQMVDEGY-LNKPREVVTLISAVAYLDN
 .    ....  .|. .. | |  .| . .|.         .   .|  | | |     | |  .|. ..||.|.|..|| .   | .||..||  |  .
hl..tsfnqfsvfkrple.ipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgq

FRNHAAVLQVDND
  | |||. .|. 
ndntaavfsidkk