Gene F49E11.7 in Caenorhabditis elegans

Synonym: CELE_F49E11.7, F49E11.7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP093_AA protein Get Run
CeleP093_AA_17-326 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP3C_pd Subfamily PPP3C 5-324 2.7e-68 223.8 In-house 17-321 (452) alignment 
Range on Protein: 5-324
Range on HMM: 17-321/452.0
KKMFDINEFlKRHLFVKNWVNyRQQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCnqnskedakkkAAYGFCNSRFVFLGD
...|| ..   .. ..|. .  ..   .. . ...||.. . |. ..|| ... |.|..||||||. ||....             .    .....||||
eevfdetgk.pklevlkehfl.kegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfe...........vgGdPastkylflGd

YVDRGHHSIECISLVFALKVVYPTNYILLRGNHETKSINYTYGFREELVNRLgpidGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINE
||||| .||||.  ..|||. ||... |||||||.. .   . |.||.  .     . |... .  .|  .||| |. .. ||.|||.||...||..|..
yvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckiky....seevydacmesfdslPlaallnqqflcvhGGlspeikslddikk

IDRpVAEILPDSLAQDLLWADPADGQGAMTvrSTPEYVPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFAD------QKLLTIFSAPRY
.||   |.    .  ||||.||..  | ..  .. ..||| ||| |.... .|| .  .. ..  |.|||.   .|.. . .        |.|.|||| |
ldr.fkeppasGplcdllWsdPledygeek..teekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapny

MNETDNHGATLRVETDgKLNIGRFRH
..  .| .| |..|.. ..|| .|. 
ldvynnkaavlkyenn.vmnirqfns
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 9-313 1.1e-86 283.6 In-house 2-282 (298) alignment 
Range on Protein: 9-313
Range on HMM: 2-282/298.0
DINEFLKRHLFVKNWVNYRQQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNqnskedakkkAAYGfCNSRFVFLGDYVDR
...|.| ..| |    .   .. .. ....||| ..  ..   .| .. .|... |||||||.||.|.. .          |..   .. ..||||||||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdk..........agfp.pdanylflGdyvdr

GHHSIECISLVFALKVVYPTNYILLRGNHETKSINYTYGFREELVNRLGPIDgfeIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRP
|....| | |..| || ||.|..|||||||...|| .||| ||  .|   .    ... |. .|...||..|.|..|||||||.|.||.||....|. ||
GrqnlevivlllaykvkypnnffllrGnheceainrvyGfyeeckrrykslr...lyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrp

VAEILPdSLAQDLLWADPADGQGamtvrstpEYVPNgVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGAT
. .  . ||| |||||||.. .         .. .|  || |..| | .|.| ...|.|.|.|||||.. .|..|||..||.||||||.|... ||  |.
fdskee.slaidllwadpenavk........gwaen.srGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaav

LRVET
..|. 
mkvde
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 9-313 6.9e-74 241.8 In-house 2-282 (299) alignment 
Range on Protein: 9-313
Range on HMM: 2-282/299.0
DINEFLKRHLFVKNWVNYRQQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcnqnskedakKKAAYGfCNSRFVFLGDYVDR
|..|.| . | |    .   .|  . ||..| .    ..  . .| .. .|. ..||||||| ||.|..          .|| .   .. |.||||||||
dvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrif..........dkagfp.pdvnflflgdyvdr

GHHSIECISLVFALKVVYPTNYILLRGNHETKSINYTYGFREELVNRLgpiDGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRP
|   .| |.|... |. || .. .||||||  .||  ||| ||  .|        .|  |. ||..|||. |.| .|||||||.||||..|  . .. ||
grqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkry...kstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrp

VAEILPdSLAQDLLWADPADgqgamtvrSTPEYVPNgVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGAT
     | ||  ||||||| .        |  .. .| |||.|..| .  |.|...||.|.|. ||||.. .|..|||..||.|||||| |  . ||  |.
qdppnp.slgidllwadpdq........svkdwlan.vrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaai

LRVET
..|. 
mkvde
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 12-313 4.2e-63 206.4 In-house 2-280 (307) alignment 
Range on Protein: 12-313
Range on HMM: 2-280/307.0
EFLKRHLFVKNWvNYRQQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQNSKedakkkaaygfCNSRFVFLGDYVDRGHH
.||.||  | .    ..  ||| |. ..|   .. .| . .|  | ||. .|||.|||. ||. ..                  .. .|| |||||||  
dfldrhyqviqa.gvhkiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrp...........petvyvftgdyvdrgll

SIECISLVFALKVVYPTNYILLRGNHETKSINYTYGFREELVNRLgPIDGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAE
|.||| |.|. |..|| | .|||||||   .|  ||| || |  . |  | |||  |. .|  .|...|.  ||||||||.|| |  | |. .  .|. .
slecilllftykicypenivllrgnheiarvnkkygfyeecvtsi.pkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirn

ILpDSLAQDLLWADPADgqgamtvrSTPEYVpNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRV
 .   . .|.|||||          |  |.     ||  | |    . | |||| ..||.|||||  .|.  .. .||.|||||| | |   | |. |.|
pf.rgivndmlwadpdp........svfewk.assrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkv

ET
. 
de
0045823 Metallo-dependent phosphatases 18-326 7.7e-89 291.5 In-house 37-325 (473) alignment 
Range on Protein: 18-326
Range on HMM: 37-325/473.0
LfvknwvnYRQQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQNSKEDAkkkaaygfcnsRFVFLGDYVDRGHHSIECIS
|       .... ... .|..|.. .   |.  ..| ..|......||||||. || |.|   .  ..            |.|||||.||||..|.|.. 
l.......kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfpped...........rlvflGDlvDrGpdslevle

LVFALKVVYPTNYILLRGNHETKSINYTYGFREELVNRLgpidGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVaEILPDSL
|..|||. ||.| .|||||||.. .|. |||..|.  ..    | ...|.|.  ....|||...|.|||..|||.|| |..|..|.||.||  ||. |.|
lllalkikypgnvfllrGNHElrllnglygfgdetleky....gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpl.eipddgl

AQDLLWADPadGQGAMTVRSTPEYVPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQK------LLTIFSAPRYMNETDNHGATLRV
. ||||.||       . ..   . .| .|| ...|.. ||.. .|. ...||||.|.. |||.... | |      ..|.|||| |.....| .| |..
lldllwsdP..weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvi

ETDGkLNIGRFRHKK
. |. ...  |.  .
dedl.isfiqfdpsp
subfamily_PPP6C_pd Subfamily PPP6C 22-316 1.6e-57 187.9 In-house 4-275 (290) alignment 
Range on Protein: 22-316
Range on HMM: 4-275/290.0
NWVNYRQ--QSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcnqnskedakkKAAYGFCNSRFVFLGDYVDRGHHSIECISLV
.|..  .  .  .. .| .| . |   |. . ..  .| |||..||||||. ||. ..           ...  . ....|||||.||||..|.| ....
kwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelf...........rtggqvpdtsyvflgdfvdrgyysletftrl

FALKVVYPTNYILLRGNHETKSINYTYGFREELVNRLGPIDgfeIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPvAEILPDSLAQ
..||. || . .|||||||.. |   ||| .| .|. |  .    |  .   |  ...| .. ...||.|||.||... |..|. |.|   ||  .    
ltlkakypdritllrgnhesrqitqvygfydeclnkygnan...awkyctkvfdlltiaaiideqvlcvhGglspdvktldqirviera.qeiphkgafc

DLLWADPADGQGAMTvrStPeyvpngvRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGK
||.|.|| | .  ..  | |       ||  ..| .  ... ..  |..||.||||.. ||.|.. |.|| |..||| |     |  . |..|.. .
dlvwsdpedvetwav..s.p.......rgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaee
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 25-326 1.3e-172 565.9 In-house 1-302 (302) alignment 
Range on Protein: 25-326
Range on HMM: 1-302/302.0
NYRQQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQNSKEDAKKKAAYGFCNSRFVFLGDYVDRGHHSIECISLVFALKV
.||...|.|.||..|||.|...|....|||.||||||||||||||..||||.|....|||.||||.||.|....|||||||||||..|||||.|||||||
kyrkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkv

VYPTNYILLRGNHETKSINYTYGFREELVNRLGPIDGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEILPDSLAQDLLWA
.|||||||||||||||.||..|||||||.||||. ||.||||.||..||.||||.|||.||||.||||||||.||..|..|.||..|. .||||||||.|
lyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfa

DPADGQGAMTVRSTPEYVPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKLNIGRFRH
||.|.|....|...|.|. | |||||..||||||||.|||||..||||||||||||||||||.||||||||||||||.||.||.|.|.|.|||.|...|.
dpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn

KK
||
kk
0049330 Metallo-dependent phosphatases 25-324 1.3e-80 263.8 In-house 24-298 (309) alignment 
Range on Protein: 25-324
Range on HMM: 24-298/309.0
NYRQQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQNSKedakkkaaygFCnSRFVFLGDYVDRGHHSIECISLVFALKV
 .... ... ||..|.. .   |   ..| ..| .....||||||. || |.|   .             .  |.|||||.||||..|.|.. |..|||.
llklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfp..........pe.drlvflGDlvdrGpdslevlllllalkl

VYPTNYILLRGNHETKSINYTYGFREELVNRLgpidGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVaEILPDSLAQDLLWA
 || | .|||||||.  .|. |||..|.. ..    | |.||.|.  ....|||...|.||||.|||.|| |..|..|.|..||. ||  |.|  ||||.
lypdnvfllrGNHElrllnglygfgdetlrky....gaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpl.eipldgllcdllws

DPADGQGAmtvrstpeYVPNGvRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKLNIGRFRH
|| .            ..||  |||...|.. ||.. .|.....||.|.|.. ..|...|.|.||.|.||||.|.....|.|| |... |.....  |. 
dplpireg........fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfep
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 26-326 4e-173 567.6 In-house 1-301 (302) alignment 
Range on Protein: 26-326
Range on HMM: 1-301/302.0
YRQQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQNSKEDAKKKAAYGFCNSRFVFLGDYVDRGHHSIECISLVFALKVV
||...|.|.||..|||.|...|....|||.||||||||||||||..||||.|....|||.||||.||.|....|||||||||||..|||||.|||||||.
yrkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvl

YPTNYILLRGNHETKSINYTYGFREELVNRLGPIDGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEILPDSLAQDLLWAD
|||||||||||||||.||..|||||||.||||. ||.||||.||..||.||||.|||.||||.||||||||.||..|..|.||..|. .||||||||.||
yptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfad

PADGQGAMTVRSTPEYVPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKLNIGRFRHK
|.|.|....|...|.|. | |||||..||||||||.|||||..||||||||||||||||||.||||||||||||||.||.||.|.|.|.|||.|...|.|
pldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrnk

K
|
k
0053225 Metallo-dependent phosphatases 26-320 3.4e-76 249.4 In-house 17-286 (293) alignment 
Range on Protein: 26-320
Range on HMM: 17-286/293.0
YRQQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQNSKedakkkaaygfCNSRFVFLGDYVDRGHHSIECISLVFALKVV
.... ....||..|.. .   |.  ..| ..| .....|||||.. || ..|   .              ..|.|||||.||||..|.|.. |..|||..
lllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfp...........pedrlvflGDlvdrGpdslevlelllalkll

YPTNYILLRGNHETKSINYTYGFREELVNRLGpidGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEIlPDSLAQDLLWAD
||.| .|||||||.. .|. |||..| . ..|   ..|.|....  ....|||.|.|.|||..|||.|| |..|..|.||.||  .   ..|  |||| |
ypdnvvllrGNHElmllnglygfgdetlrkyg...aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplrip.legllldllwsd

PadgqgamtvRSTPEYVPNgVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKLNIG
|         .   ...|.  |||...|.. ||.. .|. ...||.|.||. |.|.... |.||.|.||||.|.....|.|| | .... . .. 
p.........dlwsgwlps.yrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfk
subfamily_PPP7C_pd Subfamily PPP7C 26-207 2.4e-34 111.7 In-house 29-201 (383) alignment 
Range on Protein: 26-207
Range on HMM: 29-201/383.0
YRQQSYTKYELMQLIESV---EAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcnqnskedakKKAAYGFCNSRFVFLGDYVDRGHHSIECISLVFAL
 ... ..|| |. | |.    ..  ..    . ||  ||. ||.||.  ||. .|           |  .   .  .|| ||.||||..|.| . ...||
ekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllil..........yknGlpseenpyvfnGdfvdrGkesveillillal

KVVYPTNYILLRGNHETKSINYTYGFREELVNRLgPIDGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKlHSLKEINEIDR
 .|||..  | ||||| . .|  |||  |. ..  .  | .| . ..  |.|.|||.|. .||| .||||| |  .|. ...|.|
llvypkevylnrGnhedhilnlryGfikevesky.kvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkier
subfamily_PPP1C_pd Subfamily PPP1C 27-316 1.1e-85 280.2 In-house 6-270 (282) alignment 
Range on Protein: 27-316
Range on HMM: 6-270/282.0
RQQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQNSKEDAkkkaaygfcnsRFVFLGDYVDRGHHSIECISLVFALKVVY
.. . .. |. .|... ...|  . .| ... ||.||||||||| ||.|.. .... ...           ...|||||||||..|.| | |..|.|. |
kevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpes...........nylflGdyvdrGkqsletivlllaykiky

PTNYILLRGNHETKSINYTYGFREELVNRLGPIdgfeIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVaEILPDSLAQDLLWADP
|.|  |||||||..||| .||| .|  .|..      .|..|. .|...||| || .||||.|||.||.|.||..|..| ||. |.  ..|. ||||.||
penlfllrGnhesasinriyGfydeckrrysik....lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPl.evpekgllcdllWsdp

aDGQgAMtvrstpEYVPNGvRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGK
 | .  .      ..  |  || || |.. .|.. ... ...|||||||.. .|..|||...|.|.|||| |..| ||.|| |.|... .
.dke.vl......gwsend.rGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeell
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 28-316 5.4e-73 238.6 In-house 5-268 (281) alignment 
Range on Protein: 28-316
Range on HMM: 5-268/281.0
QQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQNSKEDAKkkaaygfcnsrFVFLGDYVDRGHHSIECISLVFALKVVYP
.  ||| |....|  ||| .| ...|..| .|...|||.|.|. || |..  ..   . .           .|||||||||| .|.|.. |.|.||. |.
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeev...........lvflgdyvdrgpqslevlillftlkiryr

TNYILLRGNHETKSINYTYGFREELVNrlgpIDGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEiLPDSLAQDLLWADPA
 . .|||||||. |.|  ||| .| |       | |.|  |.  |  .|.. |. ...||||||.||.| .| |. .. .|. . |   |  ||||||| 
drivllrgnheiasvnkiygfyvecvt....kyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirn.ldrGlviDllwadpd

DgqgamtvrSTPEYVpNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGK
.        .. |.  . .|| ||.| .. | |.||||...||.||||.. .|.. .. .||.|.||.| | .   | .| |.|. . .
n........kveewk.assrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlg
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 28-322 6.3e-73 238.7 In-house 5-280 (284) alignment 
Range on Protein: 28-322
Range on HMM: 5-280/284.0
QQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcNQNSKEDAKK---KaaygfcnSRFVFLGDYVDRGHHSIECISLVFALKV
|. ....||..|      ..  ..   .|  ||.||||||||. ||. .| . |    ...   .       ....||||||||| .||| |.|.||.|.
qkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllall.dlngwpfvedeake.......kkylflgdyvdrgpfsievitllfaykl

VYPTNYILLRGNHETKSINYTYGFREELVNRLGpidgFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVaEILPDSLAQDLLWA
..| . .|||||||.. .|  ||| .| ..|        ..| |..||  |||...|..||.||||||| .| .||......||. .|    .  || ||
llpdkvfllrgnhesrpvnmqygfyleckkrys....ealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpi.dipdigviadltwa

DPAdgqgaMTVrstpEYVPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKLNIGRF
||      ..|    |.  .  ||   .| ..||.. .|. ...|.|||||.. .|..||||.||.|||||| |  ..|| .| |.|...    .  .
dpe.....aev....egykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvl
subfamily_PPP5C_pd Subfamily PPP5C 28-322 3e-53 173.9 In-house 32-306 (322) alignment 
Range on Protein: 28-322
Range on HMM: 32-306/322.0
Q---QSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcNQNSKEDAKKkaAygfcnsrFVFLGDYVDRGHHSIECISLVFALKV
.   . |.   |..  | ...  |. ..  . .  .|. ||||||. ||. .. . | .   ..  .       ..| ||.|||| .|.|.| .....|.
kklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnif.elnGlpseen..p.......ylfnGdfvdrGsfsveviltllgfkl

VYPTNYILLRGNHETKSINYTYGFREELVNRLGpidgFEIWERFNVAFSWMPLACLVGHKILCMHGGISP-KLHSLKEINEIDRPVAEIlPDSLAQDLLW
.|| .. | |||||....|  |||..|  ..       .. . |.  |.|.||| .. .|.| .|||.   .  .|... .|||   .   ..|  .|||
lyPnhfflsrGnhesdnmnklyGfegevkakyt....ekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqpp.eegllvellw

ADPADGQGAMTVRstpeyvpngvRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRV-ETDGKLNIGRF
.|| . .| .. .          ||... |     .  .|  |..||.|.|..  ||...  | ||.|.|||| | ....|.|| ... ..| ||..  |
sdpqeanGrspsk..........rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktf
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 28-77 1.5e-07 23.9 In-house 6-55 (317) alignment 
Range on Protein: 28-77
Range on HMM: 6-55/317.0
QQSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVL
|. ....||..|      ..  ..   ..  |||||||||||. ||. .|
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllall
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 29-324 8.9e-79 257.4 In-house 8-281 (287) alignment 
Range on Protein: 29-324
Range on HMM: 8-281/287.0
QSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcnqnskeDAKKKAaygfCNSRFVFLGDYVDRGHHSIECISLVFALKVVYPT
....  ......| .|  |   ..| ..  |.|||||||||. ||.|..       .|  .|     . ...||||||||| .|.| . |.|.||. || 
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrif.......navGaa....pkvqylflGdyvdrGakslevslllfslkiaypk

NYILLRGNHETKSINYTYGFREELVNRLGpidgFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEILP-DSLAQDLLWADPA
.  ||||||| | || .|||.||| .. .     .....||  || .||   |...||||||||||||.||.... . .|  ..   . |  ||||||| 
kvhllrGnhevkkinklyGfkeelkrkrq....erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpe

DGqgAMTVRstpeyvPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKLNIGRFRH
    | |..      .| .|..| .| .  | | .|.|.|.||||||..  ||..|..|..|.|.||||.|. |  | || . |.   .|..  .. 
kd..aktfe......lnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 29-323 3.8e-64 209.5 In-house 14-287 (290) alignment 
Range on Protein: 29-323
Range on HMM: 14-287/290.0
QSYTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcnqnskeDAkkkAAYgFCNSRFVFLGDYVDRGHHSIECISLVFALKVVYPT
....  ......| .|  |    .| ..  |..||||||||  .|.| .       ||     |   . .|.||||||||| .|.|   |.| .|. |. 
dafsdkdileilekieeileplpalleveapivivgdihgqldallryf.......da...vgy.ppkvkflflgdyvdrgakslevslllfcykirysk

NYILLRGNHETKSINYTYGFREELVNRLgpidGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEILP-DSLAQDLLWADPA
.  |||||||.. .|  |||.|||. .     | ..| ...  |. ..| . ||.||||||||||.|..| . .. . .| ..    . |  |||||||.
kvhllrgnhevrkvnrlygfkeelarkr....gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadpt

DGQGAmTVRStpeyvpNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKLNIGRFR
  .   |..       |  |..| .| . .. | .|.| ..||||||..  |||.|  |.||.|.|||| |  .  | || ..|    .|.|  ..
rdkdd.tial......nkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlk
PPP_3 31-317 1e-79 260.4 In-house 2-264 (271) alignment 
Range on Protein: 31-317
Range on HMM: 2-264/271.0
YTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQNSKEDakkkaaygfcnSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNY
... || .|.....  |.  ..| .|| |||..||||||. ||...  |  . ..           ....|||||||||..|.|.. |..|||..||.. 
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspe...........tkYlFlGdyVDrGkkslEvlllLlalkikypkev

ILLRGNHETKSINYTYGFREELVNRLGpidGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEILpDSLAQDLLWADPAdgq
.|||||||...|| .|||..|.... |   | .......  |...||| |. .|.|..|||.||...||..|....|.      ...  |||. ...   
hLlRGnhEsrqinkvYgFkkevlkkkg...gkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpe.egklldlllssdp...

gamtvrSTPEYVPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKL
      .. | . | .||....| . .... ... ...||.|||.. .||.....|.|..|.|||| |.....| || |..|.. . 
......ekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealts
subfamily_PPZ_pd Subfamily PPZ 31-312 3.3e-62 203.7 In-house 25-281 (300) alignment 
Range on Protein: 31-312
Range on HMM: 25-281/300.0
YTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCnqnskedakkKAAYGfCNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNY
  . |..|.       .  . .| ..||.| ||||.|||| ||.|..           |. .    . ..|||||||||..|.| | |... |. || |.
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlft..........kcgfp.psanylflgdyvdrgkqsletillllcykikypenf

ILLRGNHETKSINYTYGFREELVNRLgpidGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVaEILPDSLAQDLLWADPADgq
.|||||||   .   ||| .|   |       .||. |  .|  .|||..|  ||.|.|||.|| | |. ||  . ||  ..    | .||||.||.|  
fllrgnhecanvtrvygfydeckrrc....nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrpt.dvpdfglindllwsdptd..

gamtvrSTPEYVPNgVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVE
      |. |.  |  ||.|. .|. |.    ... ..|..||| .. .|..|| |. |.|.|||| |  | || || . | 
......ssnewedn.ergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvs
subfamily_PPP2C_pd Subfamily PPP2C 31-318 5.9e-58 189.3 In-house 17-279 (290) alignment 
Range on Protein: 31-318
Range on HMM: 17-279/290.0
YTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcnqnskedakkKAAYGFCNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNY
 .. |. .|.| ..  || .. . ... |||..||.|||. ||. ..           |      .. ..|||||||||..|.|...|. |||| |.   
leesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelf...........kiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeri

ILLRGNHETKSINYTYGFREELVNRLGPIdgfEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRpVAEILPDSLAQDLLWADPADGQ
 .||||||.. |   ||| .| . . |     ..|. |   | ..||..|| ..|.|.|||.||....| .|...|| . |.  .    ||||.|| | .
tilrgnhesrqitqvygfydeclrkygna...nvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldr.lqevphegplcdllwsdpddrg

GAMTvrStPeyvpngvRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKLN
|  .  | |       ||  . | .   ..  |. ...||.||||.. ||...  |... |||||| | .   |..| | .. . | .
gwgi..s.p.......rgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkys
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 31-312 2.8e-56 184.0 In-house 6-262 (280) alignment 
Range on Protein: 31-312
Range on HMM: 6-262/280.0
YTKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcnqnskeDAKKKaaygFCNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNY
 | .|.. .|  ||| .  .  |..   |. ..|||| || |. |..       |   .      . ...||||||||| . || . |.|.||. |    
mtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlf.......dligr....vpeeklmflgdyvdrgpqgievlillfclkiryrdri

ILLRGNHETKSINYTYGFREELVNRLgpidGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVaEILPDSLAQDLLWADPADgQ
 |||||||| |.|  |||  |   .     |  .|  |. .|  ||.. |. ...||||||.||.|  |  | .| ||. | |   |  ||||.||.. .
yllrgnhetpsvnkiygfyvecqyky....gvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpc.epldrgllidllwsdptn.k

GAMTVRStpeyvpngVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVE
|   ..|        .||.|..| .. | ..|| |.|.||.||||.. .|....| ..|.|.|| | |  .  |  | . ..
gegwfhs........irgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvcln
PP2Ac_SM00156 32-325 2e-105 344.7 In-house 2-270 (271) alignment 
Range on Protein: 32-325
Range on HMM: 2-270/271.0
TKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcnqnskedakKKAAyGFCNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYI
.| |...|.|.|.. |. ...| ..|.|||.|||||||. ||.|.|          ..|   ......||||||||||..|||.|.|.||||..||....
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll..........elag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvv

LLRGNHETKSINYTYGFREELVNRLgpidGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRpVAEILPDSLAQDLLWADPadgqg
|||||||..|.| .|||.||. ..     | ||.|.|. |||..|||.||..||||||||.||.|.||..|....| |.|.  ..|. ||||.||     
LLRGnHEsssvnkiygfeeevkrky....gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr.vkekpeegllidllwsdp.....

amtVRSTPEYVPNGvRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKLNIGRFRHK
    ...... |.  ||||..|.|.||....|..|..||.|||....||..||||.||.||||||.|..|..|..|.|.||.. ||.| .....
...eqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_PPP4C_pd Subfamily PPP4C 32-318 2.3e-62 203.8 In-house 17-278 (288) alignment 
Range on Protein: 32-318
Range on HMM: 17-278/288.0
TKYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQNSKEdakkkaaygfcNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYI
.. |. .| ....  |  .  . ..  |||. ||||||. ||....    . .           . ...||||.||||..|.|.. |. |||| || .  
keeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvp...........etnylflgdfvdrgfysvetfllllalkvrypdrit

LLRGNHETKSINYTYGFREELVNRLGPIdgfEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRpVAEILPDSLAQDLLWADPADGQG
|.|||||...|  .||| .| ... | .   ..|.     | ...||... .||.|.|||.||....| ||  |||   |.  .    ||||.|| | .|
lirgnhesrqitqvygfydeclrkygsa...nvwryctevfdylslaaiidgkifcvhgglspsistldeirsidr.kqevphegplcdllwsdpedaeg

AMTvrsTPeyvpngvRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKLN
  .   .|       ||  ..| . .| . ... .|.||.||||.. ||.|.  ..|.||..||| |     |  | |... . . .
wav...sp.......rgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkd
PPP_1 33-310 8.2e-74 241.2 In-house 3-263 (264) alignment 
Range on Protein: 33-310
Range on HMM: 3-263/264.0
KYELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcnQNSKEDAkkkaaygfcNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYIL
. ||..|.....  |. ...| ..| ..|..||||||. ||...   ..... .         .....|||||||||..|.|.. |..|||..|| .  |
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklf..kvggpsp.........etnYlFlGDyVDRGkdSvEilllLlalklkypkelfl

LRGNHETKSINYTYGFREELVNRLGpidGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVaEILPDSLAQDLLWADPADGqgA
||||||..... .|||..|.... .   . ||.. .  .| ..|||.|. .|||..|||.||.|..|..|....|   |.  .. ..|||..|  .    
lRGNHEsrqvtkvygFkkEvlkkky...skeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrkt.evpeegklcdllekdvdil..l

MTVRSTPEYVPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLR
 . ... | |.| .|| ...|.. .... ... |..||.|||.. .||..|....|..|||||. |..|..|.|| ..
sddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 34-313 2.1e-77 253.0 In-house 9-263 (280) alignment 
Range on Protein: 34-313
Range on HMM: 9-263/280.0
YELMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQnskedakkkaayGF-CNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYIL
 .. ..|| ..  |... |. ..  ||...||.||||.||.|.. .             .|  .. ..|||||||||.. .| | |..| || || |...
adidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarv............sfppdqnylflgdyvdrgrqqlevillllaykvrypnnfli

LRGNHETKSINYTYGFREELVNRlgpiDGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEiLPDSLAQDLLWADPADGQGA
||||||. ||| .|||..|  .|       .... |.  .  .||..||. .|||||||.|.|| ||....|. ||      ..||.|||||||.. .  
lrgnhevisinrkygfkdevkrr....yslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfds.edeclamdllwadpenkvtg

MTVRStpeyvpngvRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVET
 .  |         || | || .  |.| ...|.|.||.| ||.. .|..||||.||.|.||||.|..| ||  | |.|. 
waens.........rgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivde
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 36-311 2.2e-59 194.2 In-house 28-281 (297) alignment 
Range on Protein: 36-311
Range on HMM: 28-281/297.0
LMQLIESVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLCNQNSKedakkkaaygfCNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYILLRG
...|..     .  . .. ..  |. ..||||||.|||.|..                   . ..|||||||||. ||| | |..| || .|.|..||||
vlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwp...........ptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrg

NHETKSINYTYGFREELVNRLGPIdgfEIWERFNVAFSWMPLACLVGHKILCMHGGISP---KLHSLKEINEIDRPVAEilPDSLAQDLLWADPADGQGA
||| . .| .||| ||  .|   .    ..  |.  | |.||. |.  ||||||||.||   |  .|. ...|.|.      ..|  |||||||  |   
nhecefvnkvygfyeecqkryqsv...rmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg..kerlvadllwadpisglsg

MTvrstpeyvpNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRV
.          .  ||    |   || . |  ....|..||||.. .|..||| .||.||||||.|  . ||  | . .
fm.........enqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmsc
Pribosyl_synth Phosphoribosyl synthetase-associated domain 41-71 8.5e-06 12.0 Pfam-A 56-86 (184) alignment 
Range on Protein: 41-71
Range on HMM: 56-86/184.0
ESVEAALSVDDTLAKISPPVTIVGDIHGQYP
..|...|..  ..||  ||.|.|||..|.  
savskslelpelaakekppltvvGdvgGria
subfamily_PPG1_pd Subfamily PPG1 42-314 4.1e-53 173.6 In-house 25-285 (300) alignment 
Range on Protein: 42-314
Range on HMM: 25-285/300.0
SVEAALSVDDTLAKISPPVTIVGDIHGQYPDLVRVLcnqnskedakkKAAYGFCNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYILLRGNHETKS
 .   |  .  . .|  |||.|||.|||. |.. ..           |      .. ..|||||||||..|.| |||. .||. ||.   |||||||.. 
klkellvkesnvieirspvtvvgdvhgqfydvleif...........kiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrq

INYTYGFREELVNRLGPidGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRpVAEILPDSLAQDLLWADPADGQGAMTVRS--TP
|  .|||  | ... |      .|. .   | .. ||... ..| |.|||.||.  |. .|. .||   |.  .    ||||.|| . . .   .     
itqvygfyteclrkygg..nsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldr.frevpnegaladllwsdpeennnptldhpdreg

EYVPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETD
..  .  ||  . . .  |    .  ..| |.||||.  ||.. . |.|| |..||| | .   |. . | ..  
qhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyek
subfamily_PPPLV_pd Subfamily PPPLV 45-309 2.8e-55 180.7 In-house 11-273 (290) alignment 
Range on Protein: 45-309
Range on HMM: 11-273/290.0
AALSVDDTLAKISPPVTIVGDIHGQYPDLVRVlcnqnskEDAKKKAAYGFCNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYILLRGNHETKSINY
  |  .. | ..  |. ..||.||.| ||.         |.   .    .. . ..|||||||||..|.| |. ..||||.||. ..||||||| .|.  
dilaaeerllelksptyvlgdlhgnyrdliyf.......ekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

TYGFREELVNRLGPIDgFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEID---RPVAE-ILPDSLAQDLLWADPADGQG--AMTVRST
.. .. |   . |     |.|| || .| ..|||  . .|..|.|.||    ..   |  |.     . . |    || |.||.|||...    .. ...
sieykgegsfkfgdsl.eevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

PE-YVPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETdNHGATL
.| .|.|  || . .| |.|.    || |.. ..|||..  .|...  . .|||.||. ||   . |. | .
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaali
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 51-313 1e-65 215.0 In-house 23-262 (284) alignment 
Range on Protein: 51-313
Range on HMM: 23-262/284.0
DTLAKISPPVTIVGDIHGQYPDLVRVLcnqnSKEDAKKKAAYgfcnsrfVFLGDYVDRGHHSIECISLVFALKVVYPTNYILLRGNHETKSINYTYGFRE
  | ..  |. |.||||||. ||.|..     |.   ..| |       .|||||||||.| .| | |.|| ||..|  ...||||||   ||  ||| |
pmlievnspinicgdihgqfsdllrlf....dkngfphrany.......lflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfye

ELVNRLgpiDGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEILPDSLAQDLLWADPADGQGAmtvrstpeYVPNgVRGLS
|   |    .   ..  |.  || |||..|||..|||||||.|  |. . ..  | ||. .  |..|| |.||.||.. |          . ||  ||.|
ecqrry...nkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkg........wnpn.srgvs

FIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVET
..|   |.|    ||.|.|.|||||.. .|..|||...|.|||||| |  . ||  | . |. 
yvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 54-312 2.5e-68 223.6 In-house 3-243 (263) alignment 
Range on Protein: 54-312
Range on HMM: 3-243/263.0
AKISPPVTIVGDIHGQYPDLVRVLcnqNSKEDAKKkaaygfcnSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYILLRGNHETKSINYTYGFREELV
 ..  |. |.|| |||| ||.|..   |.   | |        ....||||||||| ||.| | |.|.||.  | .  ||||||| |.||  |||. || 
lelqapinicgdthgqyndllrif...nacgaatk........tqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelk

NRLGPIDGFE-IWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEILPDSLAQDLLWADPAdgqgamtvRSTPEYVPNGVRGLSFI
.|.   . .| ....||  ||.|||...| ..||||||||||.|.|| .|  |  |.       || |||||||         . .  . || .| .| .
krfqreevyesvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpe........kdakgfepnkiraisnv

FNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVE
| .  | | ||||.|.|||||||..  |. ||||..|.|.||| ||  |  |. | . |.
fgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvn
Metallophos Calcineurin-like phosphoesterase 59-277 3.9e-39 128.0 Pfam-A 2-199 (200) alignment 
Range on Protein: 59-277
Range on HMM: 2-199/200.0
PVTIVGDIHGQYPDLVrvlcnqNsKEDAKKKAAYGFCNSRFVFLGDYVDRGHHSIECISLV--FALKVVYPTNYILLRGNHETKSINYTYGFREELVNR-
.....||.||.. ||          . . .|.|    .  ..||||.|||| .|.|.. |.  ..||. .|....||||||| ...|  |||..|  .. 
rilvigDlHgglddle......d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdl

-----------------------------LGPIDGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEIneidrpvaeilpdslaqdllwadp
                             |.|..|....|...  | ..||. ||. |||..||..|. . |   |                        
rglangeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi........................

adgqgamtvrstpeyvpngvrgLSFIFNEAAVRDTCKRLNINLIVRAHQMI
                       |. |.. |... ... .. |..|.|.  
......................gselfgpdalekllekygvdlvlrGHtHk
PPP_4 60-276 1.8e-58 190.8 In-house 1-196 (197) alignment 
Range on Protein: 60-276
Range on HMM: 1-196/197.0
VTIVGDIHGQYPDLVRVLCNqNSKEDAKKkaaygfcnSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYILLRGNHETKSINYTYGFREELVNRlgpi
||.|||||||. ||.  | . |. . ...        ...||||||||||..|.|.. |..|||.|||....|||||||.||.|  |||..|....    
vtvvGDiHGqlddlllkllk.ngglpsee........rsyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek....

DGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEILPDSLAQDL-LWADPAdgqgamtvRSTPEyVPNGVRGLSFIFNEAAV
.| ||.....  |...||| |. .|.|..|||.|..|.||..|..|.|..   | .....|| ||.||.        ...   . | ||| ...| . ..
hgkeilkklqdvfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr........eaqeg.lansvrGagllFgpdvt

RDTCKRLNINLIVRAHQM
.. ... |..||.|.|..
ekfleknnlkliirshel
PPP_5_Dcr2 60-276 3.3e-58 190.0 In-house 1-198 (199) alignment 
Range on Protein: 60-276
Range on HMM: 1-198/199.0
VTIVGDIHGQYPDLVRVLCnQNSkED--AkkkaaygfcNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYILLRGNHETKSINYTYGFREELVNRLg
||..||.|||. ||.  |  ..   |            . ..||||||||||..|.|.. |..|||.||| ...|||||||....|  |||..| ...  
vtvcGDlHGqlddlllilf.keg.gdpse.........erlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky.

piDGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPvAEIlP--DSLAQDL-LWADPAdgqgamtvRSTPEYVPNGVRGLSFIFN
  .| .|.. ..  |.|.||| |.  |.|..|||.||...|......|.|.  || |  .   .|| ||.||.        ... ..  | .|| ...|.
..hgkkiykilsdvfdwlPlaalidekvlvvhgglspeiksiellekierk.iei.peekgekadlllwsdpr........daqegcklnseRGagllfg

EAAVRDTCKRLNINLIVRAHQM
. .... ... |..||.|.|..
pdvtekfleknnlkliirshel
PPP_2 60-276 6.2e-58 188.8 In-house 1-197 (198) alignment 
Range on Protein: 60-276
Range on HMM: 1-197/198.0
VTIVGDIHGQYPDLVRVLCNQNSKEDakkkaaygfcnSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYILLRGNHETKSINYTYGFREELVNRLGpi
||..||.|||. ||...  |  ....           ....|||||||||..|.|.. |..|||.|||.. .|||||||.|..| .|||..|.... |  
vtvcGDlHGqldDLlilfknglpspe...........rkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkg..

dGFEIWERFNVAFSWMPLACLVGHKILCMHGGISPKLHSLKEINEIDRPVAEILPDSLAQDLlwadpaDGQGAMTVRSTPEYVPNGVRGLSFIFNEAAVR
 | .......  |...||| |. .|.|..|||.|.....|..|....|...     .| ..|        .  .. ... | . | .|| ...|.. ...
.gkkvykklqevfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll......eeeklsdpkekeellansarGagllfgpdvte

DTCKRLNINLIVRAHQM
. ... ...||.|||..
elleknklkliiRaHev
subfamily_YNL217W_pd Subfamily YNL217W 60-145 4.9e-07 22.5 In-house 12-83 (235) alignment 
Range on Protein: 60-145
Range on HMM: 12-83/235.0
VTIVGDIHGQYPDLVRVLCNQNSKEDAkkkaaygfcNSRFVFLGDYVDRGHHSIECISLVfalkvvYPTNYILLRGNHETKSIN-YT
. .|||.|| | .|...| ...   |          |   |..|| ...| .|.| .|.|        ..   ..||||   .  | 
llvvGdvhgaYDelieLlddkiggkde.........nvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllayk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 95-323 6.7e-67 218.9 In-house 99-313 (317) alignment 
Range on Protein: 95-323
Range on HMM: 99-313/317.0
CNSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYILLRGNHETKSINYTYGFREELVNRLGpidgFEIWERFNVAFSWMPLACLVGHKILCMHGGISP
......||||||||| .||| ..|.||||..|| . .|||||||....|  ||| .|  .|       ...| |..||  .||. .|..|||||||||| 
gykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrys....aalyeafqlafnvlplcavvnkkilcmhGGise

KLHSLKEINEIDRPVaEILPDSLAQDLLWADPADGQgamtvrstpEYVPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFS
.| .||......||. .|    .  || ||||             ..  .  || ...| ..||.. .|.|...|.|||||.. .|..||||.||.||||
elldlkqldklkrpl.dipdvGvladltwadpdaev.........kgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifs

APRYMNETDNHGATLRVETDGKLNIGRFR
|| |  ..|| .| |.|... |. |  .|
apsycGqldniaavlsvdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 96-324 2.3e-50 164.6 In-house 119-333 (339) alignment 
Range on Protein: 96-324
Range on HMM: 119-333/339.0
NSRFVFLGDYVDRGHHSIECISLVFALKVVYPTNYILLRGNHETKSINYTYGFREELVNRLgpiDgFEIWERFNVAFSWMPLACLVGHKILCMHGGISPK
  |..|||||||||  |.| . |. |||. ||    |||||||..|.| .|||  |.  |    |  ...| |.  |  .|.....   |.||||||| .
ykrylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry...d.aqlyecfqnmfnvfpfcavinntimcmhggiseh

LHSLKEINEIDRPVaEILPDSLAQDLLWADPADGQGAmtvrstpeYVPNgVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSA
| |....  . ||. ||    .  || ||||   .          | |   || ||.|   |.|   |.|......| ||.. .|..||  ..|.|||||
ltsfnqfsvfkrpl.eipdvgvltdltwadpdptekg........ykps.argasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsa

PRYMNETDNHGATLRVETDGKLNIGRFRH
| |  . ||  | . ..   |. |  || 
pnycgqndntaavfsidkklkisinvfrp
subfamily_PPP7C_pd Subfamily PPP7C 220-323 5.1e-15 48.1 In-house 239-333 (383) alignment 
Range on Protein: 220-323
Range on HMM: 239-333/383.0
DLLWADPADGQGAmtvrstpeyVPNGVRGLSFIFNEAAVRDTCKRLNINLIVRAHQMIPEGFKFFADQKLLTIFSAPRYMNETDNHGATLRVETDGKLNI
|.||.||   .|          .|| .||    |     ..  .. |..|..|.|.  |||..|  |.|.||||||  | .|  |.|| ... .| . .|
dilwsdpkakeGc.........kpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri

GRFR
 .. 
vqyq