Gene F52H3.6 in Caenorhabditis elegans

Synonym: CELE_F52H3.6, F52H3.6

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP094_AA protein Get Run
CeleP094_AA_19-299 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPZ_pd Subfamily PPZ 3-294 5.2e-106 347.5 In-house 2-293 (300) alignment 
Range on Protein: 3-294
Range on HMM: 2-293/300.0
NIPSFIDRLLSVNDTSNPSLTRCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICL
.|   |..||    ... .   |.....|  .  |. ...||| ...|.  .. . ||.||||.||||.| .| |||  ||||||||||||.| || | |
dideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

LMAYKIRYPNRFFILRGNHECASINRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLW
|..|||.||. ||.|||||||| . | ||||||||||  . ... | . || |||.|...|.|||.|||||  | |  ..  ..|| | |.  |  ||||
llcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllw

ADPENNMTGWAESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKP
.|| ..   | .  ||||  .    .. | .|. .||..| | ||.|||||| |. |||.||||.|||||||  ||| | | |..|||.| |
sdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 4-300 2.4e-133 437.0 In-house 3-299 (299) alignment 
Range on Protein: 4-300
Range on HMM: 3-299/299.0
IPSFIDRLLSVNdTSNPSLTRCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLL
.  .. .||.|   |. .||....| ..  . . . .... ||...||.||| |||||||||.||||||.. .|||| |.||||||||||||.||.|.||
vdellskllnvg.msekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitll

MAYKIRYPNRFFILRGNHECASINRTYGFYDECKRRY-SLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLW
...||.||.|||.||||||| .||| ||||.||..|| |  |.  ||. |. .||. .|..||.||||||| || .  || ..||| |||| || .||||
lcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllw

ADPENNMTGWAESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPAIREVK
|||.. . .|    |||| .|| |||.|  ....|||.|| ||||||||||||.|.||||||||.|||.||| ||.| ||| |...| .|||. ...|
adpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpkslk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 8-298 1.9e-159 522.5 In-house 7-297 (298) alignment 
Range on Protein: 8-298
Range on HMM: 7-297/298.0
IDRLLSVNdTSNPSLTRCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYK
. ..|||. .|. .||..|.|.|.. .||...||. .|...|||.|||.|||||||||.||||.|....||||.||||||||||||||.||||.||.|||
lievlsvs.lsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllayk

IRYPNRFFILRGNHECASINRTYGFYDECKRRY-SLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPE
..|||.||.|||||||..|||.||||.|||||| ||.||..||..||.|||.|.|.|||.|||||||.||.|..||.|..||||....|||.||||||||
vkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpe

NNMTGWAESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPAIRE
|...||||.|||||..||.|||||..||..|||..|.||||||||||||.|.||||||||.|||.|||.||||.|||.|.||||.|||. .|
navkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 12-295 1.5e-104 342.4 In-house 10-295 (297) alignment 
Range on Protein: 12-295
Range on HMM: 10-295/297.0
LSVnDTSNPSLTRCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYP
||   | .  |.. | |  .  ... . ... || .||||.||| ||||||||. ||||.| |  .||  |||||||||||||  .| | ||.|||...|
lsa.sthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfp

NRFFILRGNHECASINRTYGFYDECKRRY-SLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQ---KLVSWTQLAEITRPFDPpNNSLAMDLLWADPEN
  .|.|||||||  .|..||||.||..|| |. .|  ||..|| |||. .|. .|.|||||||    | ..   | .| |. .  ...|  |||||||  
gnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpis

NMTGWAESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPA
 ..|. |  ||    || | | .   ....||..| |||||||||||| ..||||||||.|||.||| ||.| .||.| .|||||.|.
glsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
0049330 Metallo-dependent phosphatases 20-296 3.8e-103 337.7 In-house 24-300 (309) alignment 
Range on Protein: 20-296
Range on HMM: 24-300/309.0
PSLTRCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRG
.  . ...| ..  ...|...||. . ...|....|.|.||||||..||||..... |||.....||||.|||| . |||..||.|.|..||...|.|||
llklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrG

NHECASINRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNMTGWAESSRGV
|||.. .|. |||.||..|.|.  |...|......|||.| | |.|.|.|||||  |... |..|. ||...|. .| .||||.|| .   |.|.. ||.
NHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprgl

SQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPAI
. .||...|..| .| ..||| |||..|..||..|.|..|.|.||||.|||...| .||...|| | .|| ...|. 
gvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvp
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 21-300 2.9e-180 590.5 In-house 1-280 (280) alignment 
Range on Protein: 21-300
Range on HMM: 1-280/280.0
SLTRCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGN
.|..||.|||||.|||||.|||.||||||||.||.|||||.|||||||||.|.|.|||||||||||||||||||||||||.||.|||.||||.|.|||||
tllacikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgn

HECASINRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNMTGWAESSRGVS
||..||||.|||.||.||||||||||.||.|...|||.|..||||.||||||||||||...|||..||||.....||||||||||||..|||||.|||||
hevisinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

QIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPAIREVK
.||||.||||.|||..|||||||||||||||||||||.|||.||||||.|||||.|||.|||||||||||.||||.||||
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalrevk
0045823 Metallo-dependent phosphatases 22-299 2.8e-107 352.2 In-house 39-328 (473) alignment 
Range on Protein: 22-299
Range on HMM: 39-328/473.0
LTRCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNH
    ..| |.  .......||  . ...|....|.|.||||||..||||..... |||.....||||.|||| . |||..||.|.||.||...|.|||||
kegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNH

ECASINRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPeNNMTG--------WA
|.. .|  |||.||. ..|.  ||..|......|||.| | |.|...|||||  | .. |..|| ||...|...|..||||.||  .. |        . 
ElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlrffg

ESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKR------LVTIFSAPKYCGEFDNNAAVMIVDERLiVSFEILKPAIREV
 | ||.. .||.|.|..| .|...||| |||..|..|||.. |..      ..|.|||| |||...| |||...|| | .|| ...|.  ..
nsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpl
0053225 Metallo-dependent phosphatases 22-295 6.2e-96 314.2 In-house 18-291 (293) alignment 
Range on Protein: 22-295
Range on HMM: 18-291/293.0
LTRCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNH
|. ...| ..  .......||. . ...|....|.|.|||||...|||...... |||. ...||||.|||| . |||..||.|.|..||.....|||||
llkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNH

ECASINRTYGFYDECKRRY-SLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPEnNMTGWAESSRGVS
|.. .|  |||.||..|.| . .|..........|||.| | |.|...|||||  |... |..|| ||...|...| .|||| ||    .||. | ||..
ElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrglg

QIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPA
 .||...|..| .| ..||| ||||||.|||... |..|||.||||.|.|...| .||...|| | ..| ...| 
vvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 23-295 4.9e-103 337.0 In-house 7-282 (287) alignment 
Range on Protein: 23-295
Range on HMM: 7-282/287.0
TRCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHE
. .... ||  |.||  .||    ...||.|||...||||||. ||||||| .  .|. .||||||||||| . |||. ||...||.||..  .||||||
ldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

CASINRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNN--SLAMDLLWADPENNMTGWA-ESSRGV
.  ||..|||..| ||...  ||. |...|..|||||..| ||.|||||.|.|| |. .|  ...|  | .    | .||||||||..  . . .  |..
vkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

SQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPA
|..||  .| |. .|..|||| | |.|...||.|..||||||.||||.|.||  | .||. |.. | .||  ||| 
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe
subfamily_PPP4C_pd Subfamily PPP4C 23-295 6.7e-89 290.9 In-house 13-285 (288) alignment 
Range on Protein: 23-295
Range on HMM: 13-285/288.0
TRCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHE
.. |.| ..  . .|  .||. .. . .|..|. ||||||||. |||..|.     |..|||||||.||||   .| . ||.|.|.|||.|  ..|||||
celikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhe

CASINRTYGFYDECKRRY-SLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNMtGWAESSRGVSQ
. .| ..||||||| |.| | ....   ..|..|.|.|.| |.|||.||||| .. .  ..  | |  . |..    ||||.|||.   ||| | ||   
srqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagy

IFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPA
.||.|||..|.|. .|.||.| ||.|..|| .  .....|..||| ||    | ||.. .||.|   |.|.. |
lfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 23-295 1.4e-88 289.7 In-house 13-289 (290) alignment 
Range on Protein: 23-295
Range on HMM: 13-289/290.0
TRCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHE
. .... ||  ..||  .||    ...||.|||.. ||||||  .||| |.   .||. ..|||||||||| . |||  ||. |||||...  .||||||
ldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

CASINRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPP--NNSLAMDLLWADPEN--NMTGWAESSRG
.  .|| |||..|  |. .  |.. .|..|. |.||| .. .|.|||||.|||. ||  |  ...|  |   .. | .|||||||..  . |   .  |.
vrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqra

VSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPA
.| .|| ... |. .|. ..|| | |.| ..|..|  ||.|||.|||| |.|.  |  |.. | | | .|. .||| 
isvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_PPP1C_pd Subfamily PPP1C 24-296 1.5e-129 424.2 In-house 8-280 (282) alignment 
Range on Protein: 24-296
Range on HMM: 8-280/282.0
RCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHEC
  ..||.|  ...|  .|||.|....|..||. ..|||||||.||||.|... .||..||||||||||||.| ||.|.||.||||.||...|.||||||.
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

ASINRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNMTGWAESSRGVSQIF
|||||.||||||||||||  |.. |.. ||.|||.|... .|.|.|||||..| |  |. .|.|| . |...|..||||.||.....||.|..||||  |
asinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPAI
|.|||..| .|...||| |.||||.|||||||...|||.||||.|||||||..||. |||.|.|||.||||| 
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
subfamily_PPP2C_pd Subfamily PPP2C 24-298 1e-86 283.8 In-house 15-289 (290) alignment 
Range on Protein: 24-298
Range on HMM: 15-289/290.0
RCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHEC
. ..|...  ..||  .||  .. . ||..|..||||.|||. ||| .|.     || ||||||||||||   .| ..||.| |.||..|  ||||||| 
kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhes

ASINRTYGFYDECKRRYSL-ALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPEnNMTGWAESSRGVSQI
  | . ||||||| |.|.  .... | .||..|||.|.. ..|||.||||| .. .  .. .. |  . |..    ||||.||. . .||. | ||    
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagyt

FGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPAIRE
|| |. ..| .. .. |||| ||.| .||..  |...|||||||.||    |.||.. .|..|  ||   .|| |.
fgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_PPP6C_pd Subfamily PPP6C 24-289 1.3e-79 260.4 In-house 13-278 (290) alignment 
Range on Protein: 24-289
Range on HMM: 13-278/290.0
RCINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHEC
. ..|.|.  . .. ...|| ..... |..|..||||||||. ||. .|.     ||..|.||||.||||   || . .|.. |..||.|  .||||||.
kylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhes

ASINRTYGFYDECKRRYSLA-LYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPeNNMTGWAESSRGVSQI
  | . |||||||...|  |  .. . ..|. |...|.| ....|.||||| ..    |.  |.|  . |..    ||.|.|| ...  || |.||   .
rqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagyl

FGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSF
||. |.|.|..  |..||.| ||.|..|.... |..|||..||| ||    | |.......    ..
fgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeerea
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 25-296 3.3e-110 361.0 In-house 2-275 (284) alignment 
Range on Protein: 25-296
Range on HMM: 2-275/284.0
CINEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECA
 |   |..... .. .|.  |  ..||..|| .|||||||..||||.|..  ||   ||||||||||||.. || | ||.|||. .||.||.|||||||.
lippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecs

SINRTYGFYDECKRRYSL-ALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPP-NNSLAMDLLWADPENNMTGWAESSRGVSQI
 ||. ||||.||.|||   ..|  |. .|  .|| |..  ||.|||||.|. |   .||  | |||| |  |.||.|.||.|| |   ||   ||||| .
linkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyv

FGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPAI
||.| .. . ....|||. | ||||||||||||..||||||||| |||.||| |||| |.. |..|| .|.|  
fgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprk
subfamily_PPP3C_pd Subfamily PPP3C 26-284 1.4e-74 244.5 In-house 41-312 (452) alignment 
Range on Protein: 26-284
Range on HMM: 41-312/452.0
INEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECAS
..|...  .||...|.|  . |..||.|||.|.||||||. |||..|.    | ...|||||||||||   .|..  |.| || ||...|.|||||||  
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

INRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNMTGWA-------ESSRG
.   . | .||| .|| ..|. . . |. ||| |.. .. .|.||||| .. |  .. .. |  .||.  .  ||||.|| ..    .       .| ||
lteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrG

VSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFAD------KRLVTIFSAPKYCGEFDNNAAVMIVDER
 | ...   | .| .| ..  | | |.. ..||. . .        |.|.|||| |.. ..| |||. ... 
csyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_PPG1_pd Subfamily PPG1 26-294 2.7e-72 236.6 In-house 14-295 (300) alignment 
Range on Protein: 26-294
Range on HMM: 14-295/300.0
INEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECAS
. |. .  ...|  ..|. .. ..|...|..| ||.|||. |.| ||.     || ||||||||||||   .| | ||.. |.||| |  .||||||   
lpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrq

INRTYGFYDECKRRY--SLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPE--N-------NMTG--W
| ..|||| || |.|     ... . ..|..| |.|.|   |.|.||||| .  |  |.  . |  . ||.    ||||.|||  |       .  |  .
itqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhf

AESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKP
 .| ||    .| |||. | .. ... | | ||....||. . |..| |..|||.||    | |... . |..   |.. . 
vvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyee
PP2Ac_SM00156 27-294 7.9e-112 365.7 In-house 2-269 (271) alignment 
Range on Protein: 27-294
Range on HMM: 2-269/271.0
NEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASI
.. ..  ..|.. .|| .....|||.||. |.||||||..||||....  .||...|.||||||||| |..|||.||.|.||.||.....||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNMTGWAESSRGVSQIFGAD
|..|||..|.||.|.  .|. |...|. |||.|... .|.|||||||..| |. ......|. ..|...|..||||.|||..  |.. |.||.| .||.|
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

VVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKP
.||.| .|.|..|| |.|.||..||||||||.||||||||.||.||.| |||. |.. |  |.| ||.
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
PPP_3 27-293 8e-102 332.9 In-house 3-270 (271) alignment 
Range on Protein: 27-293
Range on HMM: 3-270/271.0
NEADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASI
.| ... ...|...||  ....||..||. ||||||||..|||..|. . ..|...||||||||||| . |||..||.|.||.||.....||||||...|
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

NRTYGFYDECK-RRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNMTGWAESSRGVSQIFGA
|..|||..|.. ....  .|. .|..|. |||.|.|.......|||||... |. |. ...|. . |.... .|||. .......|...|.||.. .||.
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgp

DVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILK
||...| ||....||.| |.....|||...|...||.||||.||....| .|.. ..|.|  .|..|.
dvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 28-295 9.1e-97 316.6 In-house 10-277 (281) alignment 
Range on Protein: 28-295
Range on HMM: 10-277/281.0
EADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASIN
. .|  || .   |.  . ..||...||.| ||.|.|..|| |.|.  . .|.. ..||||||||| | |||. ||...||||..| ..|||||| ||.|
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

RTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNMTGWAESSRGVSQIFGADV
. |||| ||. .|   |. .||. ||.||. |.|. |. ||||||| .|..  .| .. .| ....  | .|||||||.|.  .| .||||.| .|| .|
kiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknv

VKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPA
|.|   .....|| |.||||||||| .. ..|.|.||.|.||  . | |||. ||| | .|.  | ||
vddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 28-293 9.1e-75 244.6 In-house 8-298 (302) alignment 
Range on Protein: 28-293
Range on HMM: 8-298/302.0
EADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRC------------SFPpDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFF
. ..  .||. .. |  . |..|. .|... ||||||. ||.||.|              ||   . ..|||||||||.. .| |||..|.|. ||... 
ksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptnyi

ILRGNHECASINRTYGFYDECKRRYSLA----LYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDP-PNNSLAMDLLWADPENNMT
.||||||. .|| .||| .| . |.. .    ....|.. | ..|| |..  .|.|.|||.|.|| |. .. .|.||.    ..||| |||.||| .  .
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

GW---------AESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILK
            .  ||.| .|    |.|. ...|..|| |.||..  |. |||||.|.||||||.|  | ||. ||. ||    .|  .|.
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 28-293 1.9e-74 243.6 In-house 9-299 (302) alignment 
Range on Protein: 28-293
Range on HMM: 9-299/302.0
EADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRC------------SFPpDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFF
. .. ..||. .. |  . |..|. .|... ||||||. ||.||.|              ||   . ..|||||||||.. .| |||..|.|. ||... 
ksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptnyi

ILRGNHECASINRTYGFYDECKRRYSLA----LYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDP-PNNSLAMDLLWADPENNMT
.||||||. .|| .||| .| . |.. .    ....|.. | ..|| |..  .|.|.|||.|.|| |. .. .|.||.    ..||| |||.||| .  .
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

GW---------AESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILK
            .  ||.| .|    |.|. ...|..|| |.||..  |. |||||.|.||||||.|  | ||. ||. ||    .|  .|.
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 28-78 3.3e-09 29.3 In-house 11-61 (317) alignment 
Range on Protein: 28-78
Range on HMM: 11-61/317.0
EADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFP
|...  .  .  ...  .  ..|..||....||||||. ||| ...   .|
ekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 29-78 2.5e-06 19.8 In-house 14-63 (339) alignment 
Range on Protein: 29-78
Range on HMM: 14-63/339.0
ADIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFP
|..  .  .. ... ..  .....|||.| ||||||. ||| ...   .|
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
PPP_1 30-279 9.4e-96 313.1 In-house 5-262 (264) alignment 
Range on Protein: 30-279
Range on HMM: 5-262/264.0
DIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINRT
 .  ...| ...|  . ...||...| ||||||||..|||..|. . ..|..|||||||||||| . .|...||.|.|..||...|.||||||.......
elaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkv

YGFYDECK-RRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLL-------WADPENNMTGWAESSRGVSQ
|||..|.. ..||  .|. ....|. |||.|.| ..|...|||||..| .  |  ...|  . |... ..|||       . |.... ...|.| ||.. 
ygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagy

IFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVM
.||.||...| .| |..||.| |.|...||||......||||||. |. |..|..|..
lfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 30-294 4.3e-89 291.7 In-house 10-274 (280) alignment 
Range on Protein: 30-294
Range on HMM: 10-274/280.0
DIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINRT
.|  .|     |.. .. ..| .||| | |||| || |. |.|.     |... .||||||||| | .||. ||.. |||| .| ..||||||  |.|. 
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

YGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNMTGWAESSRGVSQIFGADVVK
|||| ||. .| ..|. |||. ||..|....|| |..||||||| .|.    . .| || .| .  | .||||.|| |.  ||  | ||.| .||  ||.
ygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvve

DFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKP
.  . ..|||| |.|||||||||..| .||.|.|| |.|| .| | |||....  | |||. | |
qacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 30-295 2.8e-70 229.9 In-house 24-292 (307) alignment 
Range on Protein: 30-295
Range on HMM: 24-292/307.0
DIDVVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINRT
... || ..  |. .. ..|... |  | ||.|||. ||. .|     ||.  |.| |||||||   ||.| ||..||| ||.   .|||||| | .|. 
efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkk

YGFYDECKRR---YSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNMTGWAESSRGVSQIFGAD
||||.||          ..  ||  || ||. |.|. .|.|||||||  |    .| .  .|   |   .  |.|||||.  .  |  ||||    ||..
ygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtn

VVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPA
|. |   .. ..|| | ||.. |||  .. ..|.|||||| ||  . |  .|. ||| | .    . |.
viddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpe
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 33-295 6e-107 350.3 In-house 15-283 (284) alignment 
Range on Protein: 33-295
Range on HMM: 15-283/284.0
VVIEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFP------PDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASI
 .  .. ...  .   .|..||. ..||||||. ||| ...   .|       ...|||||||||||   .||| ||.|||...|.. |.||||||   .
elcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpv

NRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNMTGWAESSRGVSQIFGAD
|. |||| |||.||| |||. ||  || .||||..| .|.|||||.|..|.. .|| .. ||.| |.  .  || |||||....|..|| ||  ..|||.
nmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprgagkvfgak

VVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPA
 ||.|..|...||. | ||||.||||||||..|||||||| |||..|| |||. ||| |..|| .||| 
avkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkpd
subfamily_PPP5C_pd Subfamily PPP5C 34-283 1.8e-79 260.1 In-house 42-297 (322) alignment 
Range on Protein: 34-283
Range on HMM: 42-297/322.0
VIEKCTKILLAQATMVEVQAP----IAVCGDIHGQYTDLLRIFNRCSFPP-DQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINR
.. . ...| .....||.. .    ..||||||||. ||| ||.    |  .. ||| ||.||||   .||| .|...|. |||.||. |||||  ..|.
illeakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnk

TYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGL-SQKLVSWTQLAEITRPFDPPNNSLAMDLLWADPENNmTGWAESSRGVSQIFGADV
 ||| .|.| .|. .... |...|| |||. .|  ... .|||| |.. |.  .| .| |  .||...| ..|||.||... .| ..|.|||.  || ||
lyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea.nGrspskrGvgvqfGpdv

VKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIV-DE
 | | .. |..|| | |.| ..|||.  | .|.|.|||| || . .| .|.. . ..
tkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgd
subfamily_PPPLV_pd Subfamily PPPLV 35-285 2.3e-55 181.0 In-house 6-279 (290) alignment 
Range on Protein: 35-285
Range on HMM: 6-279/290.0
IEKCTKILLAQATMVEVQAPIAVCGDIHGQYTDLLRI---FNRC-SFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINRTY
 ..  .||.|.  ..|...|. | ||.||.| ||  .   . |        ..||||||||||   .|.|. |.| |. || ....||||||  |.  ..
cdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesi

GFYDECKRRYSLAL---YNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEI---TRPFD-P-PNNSLAMDLLWADPENN-----------MTG
 .. |.. ..   |   .. |.| |. ||| |.|  ..||.|.|. .   . .... |      .. .     ||.|.||.||...             |
eykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneG

WAE-SSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEfDNNAAVMIVDERL
... ..|| . .|..| .. | .. |.. . | |.| . |...  . ||.|.||. .|||   |.||...||.. 
fvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkkk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 48-300 2.3e-81 266.3 In-house 2-261 (263) alignment 
Range on Protein: 48-300
Range on HMM: 2-261/263.0
MVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINRTYGFYDECKRRYSL-----
..|.|||| .||| |||| ||||||| |      .||||||||||| . |||| ||.. |.  | ....||||||  .||. |||. | |.|.       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

ALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPN-NSLAMDLLWADPENNMTGWAE-SSRGVSQIFGADVVKDFTEKMNIDLI
..|| |...|...||||..| ||.|||||.| .| |  ..  |  |..  .   || ||||||||..  |.     | .|..||   | |. ....||||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

ARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIVDERLIVSFEILKPAIREVK
 | ||||. || ||||.||.|.||| .|  |. | |||..|.. | .||  |||   ||.
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfevr
subfamily_PPP7C_pd Subfamily PPP7C 51-184 2.1e-36 118.5 In-house 62-198 (383) alignment 
Range on Protein: 51-184
Range on HMM: 62-198/383.0
VQAPIAVCGDIHGQYTDLLRIFNRCSFPP-DQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINRTYGFYDECKRRY---SLALYN
.   ..||||.||.  ||| |. .  .|  ...|.| ||.||||.. .|....|.|. . ||. ... |||||   .|  |||  | . .|   .  . .
iskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilr

DFQNLFNHLPLCAMISGRIFCMHGGLSQKlVSWTQLAE
 ....|  |||...|  .|. .|||.|.|  . . | .
lledvfawlplatlidekilivhGGisdk.tdlelldk
Metallophos Calcineurin-like phosphoesterase 54-247 5.7e-41 134.0 Pfam-A 2-199 (200) alignment 
Range on Protein: 54-247
Range on HMM: 2-199/200.0
PIAVCGDIHGQYTDL----LRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLL--MAYKIRYPNRFFILRGNHECASINRTYGFYDECK----------
.|.|.||.||.. ||    |.... .. .. ...|||||.||||.  .|...||   ..|...|...| ||||||. ..|  |||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWTQLaeitrpfdppnnslamdllwadpennmtgwa
                         ..    .  ... |. |||.| . |.|...||.||  . |...                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

essrgVSQIFGADVVKDFTEKMNIDLIARGHQVV
      |  || |.. .. || ..||. |||. .
.....gselfgpdalekllekygvdlvlrGHtHk
PPP_2 55-246 1.2e-72 236.8 In-house 1-197 (198) alignment 
Range on Protein: 55-246
Range on HMM: 1-197/198.0
IAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINRTYGFYDECK-RRYSLALYNDFQNLFN
. ||||.|||..|||..|. . ..|...|||||||||||.. |||..||.|.|..||.....||||||....|..|||..|.. .... ..|. .|..|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

HLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPPNNSLAMDLL----WADPENNMTGWAESSRGVSQIFGADVVKDFTEKMNIDLIARGHQV
 |||.|.|.......|||||... ...|  ...|. . |.... .|||    . ||.......|.|.||.. .||.||.....||....|| | |.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 55-246 3.2e-70 229.2 In-house 1-196 (197) alignment 
Range on Protein: 55-246
Range on HMM: 1-196/197.0
IAVCGDIHGQYTDLLRIFNRCS-FPP-DQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINRTYGFYDECKRRYSLALYNDFQNLF
. |.||||||..||| .. ... .|. ...|.||||||||| . |||..||.|.|..||.....||||||..|.|. |||..|......  ... .|..|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPP-NNSLAMDL-LWADPENNMTGWAESSRGVSQIFGADVVKDFTEKMNIDLIARGHQV
. |||.|.|.......|||||..| |.... .|.|... | ......|| ||.||.....|.|.| ||.. .||.||...| || |..|| |.|..
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 55-247 1.4e-68 223.8 In-house 1-199 (199) alignment 
Range on Protein: 55-247
Range on HMM: 1-199/199.0
IAVCGDIHGQYTDL-LRIFNRCSFPP-DQNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINRTYGFYDECKRR-YSLALYNDFQNL
. ||||.|||. || |..|... .|. ...|.|||||||||...|||..||.|.|..||.....||||||. ..|. |||..|.... ..  .|. ....
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNHLPLCAMISGRIFCMHGGLSQKLVSWTQLAEITRPFDPP-NNSLAMDL-LWADPENNMTG-WAESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVV
|. |||.|.|.......|||||... |...|..|.|... | ..   .|| ||.||.....| ...| ||.. .|| ||...| || |..|| |.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_YNL217W_pd Subfamily YNL217W 55-174 2.6e-07 23.4 In-house 12-138 (235) alignment 
Range on Protein: 55-174
Range on HMM: 12-138/235.0
IAVCGDIHGQYTDLLRIFNRCSFPPDQN--YLFLGDYVDRGRQQLEVICLLmaykirYPNRFFILRGNHECASIN------RTYGFYDE--CKRRYS--L
. | ||.|| | .|.....      |.|   ...|| ...| ...||. ..        .    ..|||| . .       .  |. .    ..     .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles

ALYNDFQNLFNHLPLCAMISG-RIFCMHGGLSQ
.| ..  ..   |.    |..  .. .|.||. 
klskadmeyarelgfsldipsdellvvhaGlvp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 81-295 3.3e-100 328.3 In-house 101-315 (317) alignment 
Range on Protein: 81-295
Range on HMM: 101-315/317.0
QNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWT
..|||||||||||   .||. ||.|.|..||.. |.||||||  ..|. |||| |.|.||| |||. ||. || |||||... .|.|||||.|..|.. .
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QLAEITRPFDPPNNSLAMDLLWADPENNMTGWAESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMI
|| .. ||.| |.  .  || ||||.....|..||.|| ...|||. ||.|..|...||. |.||||.||||||||..||||||||.|||..|| |||. 
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDERLIVSFEILKPA
||. | .|...|.| 
vdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 81-299 1.7e-78 257.1 In-house 120-338 (339) alignment 
Range on Protein: 81-299
Range on HMM: 120-338/339.0
QNYLFLGDYVDRGRQQLEVICLLMAYKIRYPNRFFILRGNHECASINRTYGFYDECKRRYSLALYNDFQNLFNHLPLCAMISGRIFCMHGGLSQKLVSWT
. |||||||||||   .||. || | |. ||.| ..||||||  |.| .|||| | . ||   ||. |||.|| .|.||.|   |.|||||.|..| |. 
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QLAEITRPFDPPNNSLAMDLLWADPENNMTGWAESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMI
|.. . ||.. |.  .  || ||||.    |.  |.|| | .||   .. | .|...... ||||||.||||||  .|||||||||.|||. || |||. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

VDERLIVSFEILKPAIREV
.|..| .| ....|  |. 
idkklkisinvfrpesrdk
subfamily_PPP7C_pd Subfamily PPP7C 198-281 1.6e-19 62.9 In-house 238-321 (383) alignment 
Range on Protein: 198-281
Range on HMM: 238-321/383.0
MDLLWADPENNMTGWAESSRGVSQIFGADVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAAVMIV
.|.||.||....  .... ||    ||.|| |.. .| |..|. | |.  ..||||  ||...|||||  |  |  |  | . .
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvkl