Gene gsp-2 in Caenorhabditis elegans

Synonym: CELE_F56C9.1, gsp-2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP106_AA protein Get Run
CeleP106_AA_3-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049330 Metallo-dependent phosphatases 4-301 4.6e-118 386.7 In-house 5-302 (309) alignment
Range on Protein: 4-301
Range on HMM: 5-302/309.0
EKLNLDNIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETI
..| |...| .||..  ... | ..|.|.|.. |..| .||..|.|.||||.... ..||.|||..|||||.|  ||||| ...||||.|||| .|||..
dpllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevl

CLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDL
.||||.|..||.|.||||||||.. .|..|||.||..|.|...||. |.|....||.||.|..||.|.||||||||....|||...||...|. ||||||
llllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl

LWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADKK
|||||. .. |...|.||....||. .| .||.|..||||.|.|..|..||..|....|.|.||||||||...|.|.....||.|..||....|.. .
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll

subfamily_PPZ_pd Subfamily PPZ 7-300 2.7e-141 463.4 In-house 2-296 (300) alignment
Range on Protein: 7-300
Range on HMM: 2-296/300.0
NLDNIISRLLEVR-GSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
..|.|| .||.    .|  ||| | .|||  .|.|.||.||.|| ||||  ..|| ||||||| ||||||   |||| .||||||||||||||||||| |
dideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
||.||||||||||||||||||| . |.|||||||||| |||.|||| | || ||.|||.  |||| |||||| |.||..||...||||||| ||. ||||
llcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllw

SDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADK
|||      | .|.||||. .    . ||| |  .||.|||| |||||||||  | |||.|||||||||||| |..|.| | |.|||..| | | 
sdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 7-301 4.2e-131 429.6 In-house 2-297 (299) alignment
Range on Protein: 7-301
Range on HMM: 2-297/299.0
NLDNIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
..|...|.||.|  |.      . | |.. ||. ....|.||. |||.|||...|||.|||| ||||.|.  ||||..|.||||||||||.| ||.|.||
dvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
|..||||||.||.||||||| .|||.||||.||..||.  .||  | |.|. .|.. .|  .|.| |||||| ||...|.| . || | |.  |  ||||
lcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllw

SDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADKK
.|||. | .|  | ||||. ||..|||. ... |.||..||||||.|||||||...|||.|||| |||.|||. ..| ||| |.|.|..|||..|.
adpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 8-301 1.3e-138 454.1 In-house 3-297 (298) alignment
Range on Protein: 8-301
Range on HMM: 3-297/298.0
LDNIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLL
 |......|.|  |.     ...|.... |......|| .|. |.|..||.|.|||.|||| ||||||. .||||..||||||||||||.|.||.|.|||
vdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlll

AYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWS
|||.|||.|||||||||||..|||.||||.|||||| ...|...| | || ||..|.| ..|.| |||||. |.|..|.|.. ||.| ... |  ||||.
aykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwa

DPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADKK
||.. |.|| || ||||..|| .||...|.| |.||..|||||| |||||||...|||.||||.|||.|||. ..|.||| |..||..|||..|.
dpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 9-298 9.6e-107 349.6 In-house 3-295 (297) alignment
Range on Protein: 9-298
Range on HMM: 3-295/297.0
DNIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLA
|.||  .|     .      .||  .  | . . ..| .|  ..|..||.|.|||.|||. ||||||  ||.|| .||||||||||||. |.||| ||||
dsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivllla

YKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSP---DLQSMEQIRRIMRPTDVpDQGLLCDLL
||.|.| |.|||||||||  .|..||||.||..||. .... .| | || ||.. .| .||.| ||||||   .  ... .|.| |.|.   ..|..|||
ykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadll

WSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
|.||   ..|. ||.||    || . | |   . .|||.|||||||.||||||| |.|||.|||| |||.|||. ..|..|| | |||.||.|.
wadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt

0053225 Metallo-dependent phosphatases 10-297 9.3e-108 352.9 In-house 3-290 (293) alignment
Range on Protein: 10-297
Range on HMM: 3-290/293.0
NIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAY
..| .||..  .   ....|.|.|.. |... .||....|.||||.... ..||.||...|||.|.|. |||||....||||.|||| .|||...||||.
slilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllal

KIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDP
|..||.|..|||||||.. .| .|||.||..|.| . .||. ..|....||.||.|..||...|||||||| ...|||.|.||...|. |||.|||||||
kllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp

DkDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKP
| ...||. . ||....||. .| .||.|..||||.|.|||| |||... ...|||.||||||.|...|.|.....|| |...|....|
d.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap

0045823 Metallo-dependent phosphatases 16-302 2e-120 395.5 In-house 30-328 (473) alignment
Range on Protein: 16-302
Range on HMM: 30-328/473.0
LEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPE
|..  .   |. .|.|.... |... .||. ..| ||||.... ..||.|||..|||||.|  ||||| ...||||.|||| .|||...||||.|||||.
ldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypg

NFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPdKDVTG-
|.||||||||.. .| .|||.||. ..|...|.. | .....||.||.|..||...||||||||....|||.| || ..|| |||.|||||||  .. | 
nvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgd

-------WGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQ------LVTLFSAPNYCGEFDNAGSMMTVDETLmCSFQILKPADKK
       .| . ||....|||..| .||.|..||||.|.|..|..|||.. ...      ..|.||||||||...| ......||.| .||....|.. .
gllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphp

K
.
l

subfamily_PPP1C_pd Subfamily PPP1C 21-300 3e-165 541.3 In-house 2-281 (282) alignment
Range on Protein: 21-300
Range on HMM: 2-281/282.0
SKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
||.||.|.|.|.||. |..|.|||.||||||||||||.||.||.||||.|||||||..|.|||||||||||||||||||||||.||||||||||||.|||
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDR
|||||.|||||||||||||||||.|||||||||.|||||.||..||||.|.||||||.|.|.||||.|.||..||..|||||||||||||.|.||.||||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADK
|||||||..||.|||.|.|||||.||||||||||||||||||||.||||||||||||||....|||.|..||||||||.|
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 24-298 1.4e-85 279.8 In-house 11-289 (290) alignment
Range on Protein: 24-298
Range on HMM: 11-289/290.0
GKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGN
|    .....|  . .| .||.   | |||.|||. | ||.|||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.|...  |||||
gvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgn

HECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTD--VPDQGLLCDLLWSDPDK--DVTGWGEND
||.  .||.|||..|  |. . .||| . | |. |.. | ...||.| |||.|....| | .. . .|      |.||  ||||.||..  | |   .  
hevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkq

RGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
|..|  || ... ..|.|  |.|| |||.| |.|..|  ...|||.|||| |.|.  | |...|| |.|  |. .||| 
raisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 25-294 9e-78 254.5 In-house 16-288 (307) alignment
Range on Protein: 25-294
Range on HMM: 16-288/307.0
KNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNH
...| |  |.. .  ... || |.  |.... |  . ||.|||. ||. .|   | |||. |.| |||||||  |||.| ||..||| ||||  ||||||
hkiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnh

ECASINRIYGFYDECKR---RYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRG
| | .|. ||||.||     .   ..|  |  ||| ||..|.|  ||.| |||||| |  ....|   .|   | .|.. |.||.|||  |  |    ||
eiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrg

VSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQI
  |||| .|.    ..  ..|| ||||.. |||  .. |.|.|.|||| ||  . ||| .. |||||      
sgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlva

subfamily_PPP2C_pd Subfamily PPP2C 26-301 8.4e-105 343.1 In-house 14-289 (290) alignment
Range on Protein: 26-301
Range on HMM: 14-289/290.0
NVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
  ||.|||.| ||.| .||. ..  . |...|. .|||||||..||| ||  ||  |..||||||||||||  |.||..|| | |..|.|   .||||||
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhe

CASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDVTGWGENDRGVSF
   | ..||||||| |.| | ..|| ||| |..||..|..||.||| |||||| ......|| . |  .||..| |||||||||| | .|||  .||  .
srqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagy

TFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADKK
||| ..  || .. .| || ||||.| .||..  .|..||.|||||||    | .... .|..|  ||   .|| ..
tfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 26-300 5e-101 330.6 In-house 5-279 (281) alignment
Range on Protein: 26-300
Range on HMM: 5-279/281.0
NVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
.||.|. ||. . .. . || ..  | |...| .. ||.|.|. || ||||  | .||  ..|||||||||.||||.. ||...||.|... .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFT
 ||.|.||||| ||. .| ..||  |  ||| ||..| |.... | ||||||.| .....| . .| . .|.||. ||||.|||..| .| .  ||.|||
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADK
|| .|| .   . ...|| |||||| |||| .. |.|.|.||.||||  . ||.....|||||  |.. | || .
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase

subfamily_PPP3C_pd Subfamily PPP3C 26-289 1.1e-89 294.3 In-house 38-314 (452) alignment
Range on Protein: 26-289
Range on HMM: 38-314/452.0
NVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
. .|.|...  . ... ... ... |||.|||. ..||.|||.||||.||| || | ...|||||||||||  |.|..  |.| ||.||...||||||||
egrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhe

CASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWG------E-N
|  .   . | .||| .|. .........|..||.||..... .|.||||||...|...|... |  ..| .|.||||||||| .|           . .
crhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpns

DRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAK------RQLVTLFSAPNYCGEFDNAGSMMTVDETLM
 || |. .. . |..||.| ||  | |||.. ..||. . |        |.||||||||.. ..| .... ...  |
vrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 27-296 1.1e-68 224.7 In-house 5-299 (302) alignment
Range on Protein: 27-296
Range on HMM: 5-299/302.0
VQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYP
 ....||.  |...  | .  .  | |. .|. | ||.|||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlyp

ENFFLLRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWSDPD
.|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||..|| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

-KD-------VTGWGE-NDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILK
  .          . . . ||.|..|    | .. .. .|.|| ||||..  |. |||...|.|.||||.|  | || |... ||     | ..|.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 28-300 4.7e-97 317.4 In-house 9-284 (287) alignment
Range on Protein: 28-300
Range on HMM: 9-284/287.0
QLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 .....|  . .| .||.   | |||.|||..|.||.|||. ||||.|.  | .|. .||||||||||| .||| . ||...||.||..  |||||||. 
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevk

SINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP--DQGLLCDLLWSDPDKDVTGWGEND-RGVSF
 ||..|||..| ||... .|.|.| | |. ||. |.....|.| |||.||.|.|..... . .||     |.||  ||||.||.||  .   |  |..| 
kinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisv

TFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADK
 || ..| ..|.| |.||| |||.|.|.||.|.....|||.|||| |.||  | |....|...|  ||  ||| | 
vfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf

subfamily_PPP6C_pd Subfamily PPP6C 28-296 5.2e-97 317.5 In-house 14-282 (290) alignment
Range on Protein: 28-296
Range on HMM: 14-282/290.0
QLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 |.|...| ||..  ...| .  .  ...|. .|||.|||.|||. ||  ||  |...|.||||.||||  ||||. .||. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPdKDVTGWGENDRGVSFTF
 | ..|||||||...| | . || .|. |. |..||||||...| |||||||.. ..||| | | ...| .| .|||.|||| .||  |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagylf

GPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILK
| .|. .|.|  .|.|||||||.||.|.... . .|||..||||||    |  |.......   .....|
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk

subfamily_PPG1_pd Subfamily PPG1 28-299 1.2e-88 290.3 In-house 13-297 (300) alignment
Range on Protein: 28-299
Range on HMM: 13-297/300.0
QLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 | |. .| |..| .|.....  . |...|. . ||||||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..||    |||||||  
llpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesr

SINRIYGFYDECKRRY--NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPD---------KDVTG--
 | ..|||| || |.|  | ..|| .|. |. | .||||||.|.| ||||||. .|..||. . |  .||..| |.|||||||.          |  |  
qitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqh

WGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPAD
. . .||  ...| .|| |||.. |.. | ||||.. .||. .   .| |..||||||    |  |.. . | .   |.. . | 
fvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeap

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 28-297 5e-69 225.8 In-house 5-299 (302) alignment
Range on Protein: 28-297
Range on HMM: 5-299/302.0
QLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPE
....||.  |...  | .  .  | |. .|. | ||.|||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlypt

NFFLLRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWSDPD-
|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||..||  
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

KD-------VTGWGE-NDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKP
 .          . . . ||.|..|    | .. .. .|.|| ||||..  |. |||...|.|.||||.|  | || |... ||     | ..|..
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn

PPP_3 29-296 1.1e-115 378.3 In-house 2-270 (271) alignment
Range on Protein: 29-296
Range on HMM: 2-270/271.0
LTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
|.|.|.| |..| .||. ....|.|..||...|||.|||..|||.||..||..||..||||||||||||.|||...||||.|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFG
||..|||..|.. .... |..|.....|..||.||.||||....||||||...|..||... |...||..|.|.|||.|..... .|.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

PEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILK
|.|...||.|..|.||.|||...|.|||.......||.|||||||....|||......|.|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 29-297 2.5e-112 368.0 In-house 8-282 (284) alignment
Range on Protein: 29-297
Range on HMM: 8-282/284.0
LTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFP------PESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRG
|.| |.  || ..||.|  ... ||.|||.||.||.|||. ||| |..  |.|       |..|||||||||||  |.| | ||.|||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGV
|||   .|. |||| |||.||  .|...|  .||..|..|....||.| |||.| || ...|. .. ||.|.|| |...|| |.||...|.|. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKP
  .||.. | .||.|..|||. |||||| ||||||| |.|||.|||| |||..||......||| |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp

subfamily_PPP4C_pd Subfamily PPP4C 29-298 1.7e-104 342.1 In-house 16-285 (288) alignment
Range on Protein: 29-298
Range on HMM: 16-285/288.0
LTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
..|.|.| ||.|.|||.. .  . ....|  .|||.|||.||||.||. ||  || |||||||.||||. |.||. ||||.|..||..  |.|||||. .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

INRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDVTGWGENDRGVSFTFG
| ..||||||| |.| ....|.  |. |. |..|||||.|||| ||||||.......|| | | ..||..| |||||||||. |..||.   ||  . ||
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylfg

PEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
 .||..| .. |..|||||||.| .|| .  .....|..||||||    |  ... .||.|   |.|.. |
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 29-298 2.5e-88 289.2 In-house 6-275 (280) alignment
Range on Protein: 29-298
Range on HMM: 6-275/280.0
LTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
.|  ||  . .    ||. .  | | |||.|. ||.| || |. |||.  |  || . .||||||||| | .| . ||.. ||.| .  .|||||||  |
mtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetps

INRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGP
.|.||||| ||. .| . ||  |  ||| .|....| ....| ||||||.|  .. || | || .  |.||| ||||||| .   ||  . ||.|. || 
vnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgk

EVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
 || .  .  ..||| ||||||.||||..| |.|.|.|| |||| .| || ... ..  |  ||| | | 
gvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 29-82 5.6e-17 54.9 In-house 9-62 (317) alignment
Range on Protein: 29-82
Range on HMM: 9-62/317.0
LTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPP
..|.|.  || ..||.| ..|. ||||||..|.||.|||. ||| |..  |.| 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 30-298 2.3e-122 400.5 In-house 7-275 (280) alignment
Range on Protein: 30-298
Range on HMM: 7-275/280.0
TESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
 | .|... .| ..|.. |  ..|..||...|||.|||| ||||||.  .|||..||||||||||||.| || |.||||||..||.||..||||||..||
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPE
|| |||.||.||||. .|.. | . .. ||..|..  .|.| |||||..|.|........|| | .|. |  ||||.||...||||.|| ||||  || .
nrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifgan

VVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
|| .. .| |.|||.| ||||.|||||||...|||.||||.|.|||||. ... ||| |. ||..||||
vvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa

PP2Ac_SM00156 30-298 1.5e-117 384.5 In-house 2-270 (271) alignment
Range on Protein: 30-298
Range on HMM: 2-270/271.0
TESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
...|.. |.....||. ... |.|..||. ..||.|||..|||||.| .|.|||..|.|||||||||.||.|.|.||.|.||.|||...|||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPE
|.||||..|.||.|. .... |...|..||.||..|.||.| ||||||.|.|...||.. |. . |..|||.|||||||.... |.  . ||.|..||..
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

VVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
.| .||.|..|.||.|||.||..||||||...|||.|||||||.||.|......|...|..|.. ||..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq

PPP_1 30-283 4.7e-116 379.7 In-house 2-263 (264) alignment
Range on Protein: 30-283
Range on HMM: 2-263/264.0
TESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.|.|.. |..|..|.. ....|||.......|||.|||..|||.||..||..||.|||||||||||||.|.|...||||.|.|||...||||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL-------WSDPDKDVTGWGENDRG
...|||..|.. ..|. ...||.||.|..||.||.|||||...||||||.|....|||...| |.||..| |||||       .||.... ... ...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMT
....||..|..|||.|..|.||.|||.|.|.||||..||..||.|||.||. |..|.|....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 31-83 1.6e-12 40.1 In-house 13-65 (339) alignment
Range on Protein: 31-83
Range on HMM: 13-65/339.0
ESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPE
 .|.  ||...||.  |.||.|.||||. . ||.|||. ||| ...  |.|  
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 33-300 7e-107 350.1 In-house 7-276 (284) alignment
Range on Protein: 33-300
Range on HMM: 7-276/284.0
EIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRI
... |  .. .||  ||.|.| ..|..||||.|||. ||||||.  |||  .|||||||||||||. |||| ||.|||. .|. ||.|||||||. ||.|
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECKRRYNI-KLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQG-LLCDLLWSDPDKDVTGWGENDRGVSFTFGPEV
||||.||.||||   ....|   |  .|..|.. ..|.| |||.|  || . |.| | || | |.   |  |.||||| .   ||  | ||||. || . 
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

VAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADK
. |.| . ..||. ||||||.|||||||.|.|||.|||| |||.|||| ..| |.. |.||| .|.|  |
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk

subfamily_PPPLV_pd Subfamily PPPLV 36-287 4.1e-58 190.0 In-house 4-278 (290) alignment
Range on Protein: 36-287
Range on HMM: 4-278/290.0
GLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLL----RLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 ||... .|....  ||||..|  . ||.||.| ||      |.  |     ...||||||||||. |.| |. ||| |. ||  ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYNIKL---WKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQI---RRIMR--PTDVPDQGLLCDLLWSDPDKDV-----------
 . .. |.. ..  .|   |..|...|. ||.||.||.|.||.|.|.    ..  .|   . |.   . |.    |  |.|||||..|            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

TGWGEND-RGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGsMMTVDET
 |. .|| || .  |. . . .||.. .|. . |||.| | |...  | .|.|.||. .|||  ..|  .. ||. 
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaa.lilvdkk

subfamily_PPP5C_pd Subfamily PPP5C 39-287 9.8e-86 280.7 In-house 44-298 (322) alignment
Range on Protein: 39-287
Range on HMM: 44-298/322.0
QKSREIFLSQPILLELEAP----LKICGDVHGQYYDLLRLFEYGGFPPES-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIY
....|.. ..| |.|.. .    | .|||.|||.|||| .||  | | |.  ||| ||.||||  |.|.| .||..|. ||..||| |||||  ..|..|
leakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkly

GFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGL-SPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKdVTGWGENDRGVSFTFGPEVVA
|| .|.| .|. |. . ||. || ||.| .|.||.. .|||| | |  .....|.| | .. |..|||..||||||..  .| ..  |||...|||.|  
GfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvgvqfGpdvtk

KFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTV-DET
|||.. .|.|| |.|.| |.|||.  . .|.|.||||||| . .| |...|. .. 
kflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgdd

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 51-299 7.3e-74 241.7 In-house 2-257 (263) alignment
Range on Protein: 51-299
Range on HMM: 2-257/263.0
LLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNI-----
||||.||..|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.  | ...|||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPD-QGLLCDLLWSDPDKDVTGWGEND-RGVSFTFGPEVVAKFLHKHDLDLI
 ... | . |. .|..||. ..|.| |||.|| |.|...|| |  | .    . | |||||.||.||  |.  |  | .|  || . |  . .. |.|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPAD
 ||||||| || ||| |.|.|.|||  |  |. |  ... |.. |  ||  ||| |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped

Metallophos Calcineurin-like phosphoesterase 58-249 9.2e-46 149.6 Pfam-A 3-198 (200) alignment
Range on Protein: 58-249
Range on HMM: 3-198/200.0
LKICGDVHGQYYDL----LRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFLLRGNHECASINRIYGFYDECK-----------
  ..||.||...||    |.|.. .. ..  ..|||||.||||. |.||..||  |..|...| ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIrrimrptdvpdqgllcdllwsdpdkdvtgwge
                        ... . .  . ..|..|| .|..| ||...||.||....| ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGPEVVAKFLHKHDLDLICRAHQV
     |. |||... |.| |...||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH

subfamily_PPP7C_pd Subfamily PPP7C 58-190 1.8e-38 125.3 In-house 66-201 (383) alignment
Range on Protein: 58-190
Range on HMM: 66-201/383.0
LKICGDVHGQYYDLLRLFEYGGFPPE-SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY---NIKLWKTFTD
. .|||.||.  ||| ..   |.| |  .|.| ||.|||||.|.| ...|||. . ||....| |||||   .|  |||  | . .|   . |. ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPVAAIIDEKIFCCHGGLSpDLQSMEQIRRIMR
 |  ||.|..|||||. .|||.| |  ..| . .| |
vfawlplatlidekilivhGGis.dktdlelldkier

PPP_2 59-249 8.8e-84 273.1 In-house 2-197 (198) alignment
Range on Protein: 59-249
Range on HMM: 2-197/198.0
KICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECK-RRYNIKLWKTFTDCFNC
..|||.|||..|||.||..|...||..||||||||||||.|||...||||.|..||....|||||||....|..|||..|.. .... |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL----WSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQV
||.||.||||....|||||.......||... |....|..|.|.|||    .|||... ... .. ||....|||.|....|.|..|.||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev

PPP_4 59-249 1.1e-80 263.3 In-house 2-196 (197) alignment
Range on Protein: 59-249
Range on HMM: 2-196/197.0
KICGDVHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFN
 ..||.|||..|| |.|...||.|. |..|.||||||||||.|||...||||.|..||....|||||||..|.|..|||..|...... ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQV
.||.||.||||....|||||..|.|...|.|| |....| ......|| ||||| .. .|. .. ||....|||.|. |||.|..|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel

PPP_5_Dcr2 59-250 8.2e-77 250.7 In-house 2-199 (199) alignment
Range on Protein: 59-250
Range on HMM: 2-199/199.0
KICGDVHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRR-YNIKLWKTFTDCF
 .|||.|||..|| |.||. ||.|. | .|.||||||||||.|||...||||.|..||....|||||||. ..|.||||..|.... .. |..|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDVTG-WGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVV
..||.||.||||....||||||...|.|....| |....| ..|  .|| ||||| ....| . .. ||....|||.|. |||.|..|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk

subfamily_YNL217W_pd Subfamily YNL217W 59-177 1.6e-08 27.3 In-house 13-138 (235) alignment
Range on Protein: 59-177
Range on HMM: 13-138/235.0
KICGDVHGQYYDLLRLFE--YGGFPPESNYLFLGDYVDRGKQSLETICLLlaykikYPENFFLLRGNHECASINRIygfydECKRRY-------------
 . ||||| | .|..|..   ||  ..   ...|| ...| .|.|.. ..        ..   ..|||| . . ..     .  ..              
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefsskfs

NI--KLWKTFTDCFNCLPVA-AIIDEKIFCCHGGLSP
 .  || |  ..    |. .  |  ....  |.||.|
flesklskadmeyarelgfsldipsdellvvhaGlvp

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 84-298 4.6e-98 321.3 In-house 101-315 (317) alignment
Range on Protein: 84-298
Range on HMM: 101-315/317.0
SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSME
..|||||||||||  |.| . ||.|.|..||.. ||||||||  ..|. |||| |.|.||. .|...|   ||.||..|....||.| |||.| .| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMT
|. .. ||.|.|| |.|.|| |.|||..|.|. |  || .. ||.. | .||.|.||||. |||||||||||||| |.|||.||||.|||..||......
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDETLMCSFQILKPA
||. |..|...|.| 
vdkklkisinvlrpe

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 85-302 1.1e-75 247.9 In-house 121-338 (339) alignment
Range on Protein: 85-302
Range on HMM: 121-338/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQ
 |||||||||||  |.| . || | |. ||.  .|||||||  |.|  |||| | . ||. .|.. | . || .|..|.|.. |.| |||.|  | |..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTV
.  . || ..|| |.| || |.|||    |.    || || |||  .  ||.| ||... | |||||||||||  |.|||.||||||||. ||. .....
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DETLMCSFQILKPADKKK
|. |  | ....|  . |
dkklkisinvfrpesrdk

subfamily_PPP7C_pd Subfamily PPP7C 200-292 1.7e-20 66.1 In-house 237-329 (383) alignment
Range on Protein: 200-292
Range on HMM: 237-329/383.0
LCDLLWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSF
. |.||||| ..   . .  ||    |||.| .|.|.|..|.|. |.|.   .||||  .....|.||| ||  |  | |. . . ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri