Gene ppm-2 in Caenorhabditis elegans

Synonym: CELE_T23F11.1, T23F11.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1Z
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP157_AA protein Get Run
CeleP157_AA_2-286 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 3-286 3e-83 271.8 In-house 2-290 (295) alignment 
Range on Protein: 3-286
Range on HMM: 2-290/295.0
QTLSEPVTKKESASCANENYLVGSSCMQGWRVDMEDAHTHLLSLPD-DPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQ-------KEFSEGNMKEAIE
..|| |.. . . |  . .. ||....||.|  .|||....|.|.  ......|.|.|||||......   .|.. .. .        ..|. ...||..
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

KGFLELDQQMRVDEET--KDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFNRVNGNLALSRALGDFAF
|.||..|....   .   ....|||||||.||... .|..|.|||||| .  ||...|..||||..|.| .||..|||.| ..||||.||..|||||| .
kaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

KNCDTKPAEEQIVTAFPDVITDKLT-PDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSICEELLTRCLApdcqmgGLGCDNMTVVLVGL
|.. . ...|..|.|.|||.. .|| .|..|..||.||.|||..|.|.||.||. ||.  |.. ..|||. ..||      . ..||.|||.| |
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrl
subfamily_PPM1G2_pd Subfamily PPM1G2 4-286 6.3e-140 458.1 In-house 1-286 (287) alignment 
Range on Protein: 4-286
Range on HMM: 1-286/287.0
TLSEPVTKKESASCANENYLVGSSCMQGWRVDMEDAHTH---LLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEGNMKEAIEKGFLEL
||||||..||||||||... ||||.|||.|..|||||..   ||...||...|.|||.|||||.||..|.| .|.||....|.|.||.........|||.
tlsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaflet

DQQMRVDEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFNRVNGNLALSRALGDFAFKNCDTKPA
|.... ||..||...|.||||||||| ..|..|||||||| |. |... |||||||..|.|..|||||||.||.||||||||||||||||.||....|..
DeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkp

EEQIVTAFPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSICEELLTRCLAPDCQMGGLGCDNMTVVLVGL
|||||||.|||...||..|.||.||||||||||.||.||||.|||.|........|.||||..|||||....|.||||||||.| |
eeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_PPM1G_pd Subfamily PPM1G 5-111 5.7e-29 94.4 In-house 2-106 (473) alignment 
Range on Protein: 5-111
Range on HMM: 2-106/473.0
LSEPVTKKESASCANENYLVGSSCMQGWRVDMEDAHTHLLSLpdDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEGNMKEAIEKGFLELDQQM
||.| ..|||   .||.  .| | ||||||..||||. .. |  | ....|||||||||..|..|   .| . . ||| . ||....|.|. ||.||...
lskpkvekesedesneelsygasamqGwrvsqEDahncitdl..dedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDekl

RVDEETK
. .|  |
kaeeslk
PP2Cc_SM00332 16-284 7.4e-89 290.8 In-house 4-274 (274) alignment 
Range on Protein: 16-284
Range on HMM: 4-274/274.0
SCANENYLVGSSCMQGWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEG----NMKEAIEKGFLELDQQMRVDEETK
|  | ..  | |.|||||. |||||   ..|    . .||.|.||||||.|...   .|.. .  .... ..    ...||..|.||..|.... .|. |
sgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqsk

DD---VSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFNRVNGNLALSRALGDFAFKNCDtkPAEEQIVTAF
 .    ||.||||.|.|..|.|. |.|||||| .  |.|..|| ||||..|.| .|| .|||.||..||||.||.|||.||...|. .  . .|...|| 
elenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitae

PDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKR--DPQSiCEELLTRCLAPDcqmgGLGCDNMTVVLV
||| . .||...||..||.||.|||..||||||.||..||..   |||  ..|||.......    | ..||.|||.|
pdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqe.aaelldeeairr....ggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 18-286 1.3e-87 286.7 In-house 8-280 (282) alignment 
Range on Protein: 18-286
Range on HMM: 8-280/282.0
ANENYLVGSSCMQGWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFS--------EGNMKEAIEKGFLELDQQMRVDEE
 .... .| | ||||||.||||||   ||.  .. .||||.|||.||.|..|.  .|..... ..|..        . ..|||...|||.||...| ...
egnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelst

TKD--DVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFNRVNGNLALSRALGDFAFKNCDTKPAEEQIVTA
...  | ||.|||.||..|  ... |.|||||| .  |.|  |. |||||...| .|| .||| |  .||||.||.||||||...|. ..|.|||| |.|
dlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsa

FPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSICEELLTRCLAPDCQmgglgcDNMTVVLVGL
 |.| . . . ...|.||||||||||....|||..||..|  . ........|. ..|  . .      ||..|..| .
epevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsr......DNlsvlvvlf
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 21-263 3.1e-45 147.4 In-house 5-236 (255) alignment 
Range on Protein: 21-263
Range on HMM: 5-236/255.0
NYLVGSSCMQGWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEGNMKEAIEKGFLELDQQMrvdeETKDDVSGTTAV
 . || | | | |  |||  .   |  |...  ..|..|||||.. ....  .|.| .    .  . | .....| . |.. |.    . .    ||||.
rfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi....serpkfiGttaa

VVLIKEGDVYCGNAGDSRAVSS-VVGEARPLSFDHKPSHETEARRIIAAGGWVEFN----RVNGNLALSRALGDFAFKncdtkPaeeqIVTAFPDVI-TD
.||| |  ||  | ||||.| .   | |. ||.|||||.| | .|| ..|| |  .    ||||.||.||||||  ..     |     |.. ||.  . 
svliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle.....P....fvvpdPdlsqsl

KLTPDHEFIVLACDGIWDVMTNQEVVDFVreklAEKRDPQSICEELLTR
. . ...|..||||||||.....| |. |    |.  ||.  .|.|   
eiskkdkflilacdGiwdlisdeeaveiv....agisdpekaaeklrdl
subfamily_PPM1E_pd Subfamily PPM1E 22-285 3.1e-54 176.9 In-house 4-261 (265) alignment 
Range on Protein: 22-285
Range on HMM: 4-261/265.0
YLVGSSCMQGWRVDMEDAHTHL------LSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEGNMkEAIEKGFLELDQQMRVDEETKDDVS
| | . .... |  ||| |  |      . | |... |||||.|||||.. ..|.  .||. .| |... |  . ||....| ..|...    | .   |
yevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqkaereklks

GTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWV---EFNRVNGNLALSRALGDfafkncdtkPAEEQIVTAFPDVI
|.|||||||..  .| .  |||.|.    |||. |   |||..| |..|| .||| |   .  ||||.|..|||.||         . ... |.. .|| 
GstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGD.........vklkpyvsgeadva

TDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKR-DPQSICEELLTRCLAPDCQmgglgcDNMTVVLVG
. .|. ..|...|||||.|||....|||. |.| ||..  | ... ..|..     . .      ||.|||.| 
eveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss......Dnitvvvvf
PP2C Protein phosphatase 2C 24-269 3.1e-82 269.0 Pfam-A 3-251 (255) alignment 
Range on Protein: 24-269
Range on HMM: 3-251/255.0
VGSSCMQGWRVDMEDAHTHLLSL---PDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEG-NMKEAIEKGFLE-LDQQMRVDEET-KDDVSGT
||.|..||.|  |||||..| .|    .. . |||||.|||||.....| . .|....  ||.|.|. . ..|. |.||. .|.... .... ... ||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TAVVVLIKEGDVYCGNAGDSRAVSSVVGEAR-PLSFDHKPSHETEARRIIAAGGWVE-FNRVNGNLALSRALGDFAFKNCDtkpaeEQIVTAFPDVITDK
||||.||.. ..|. |.|||||| .  ..|.  |..|||||.| |..|| .|||.|. ..||||.||.||||||| .|. .     ||.|.| ||| . |
tavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsvk

LTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSICEELLTRCLAPDC
||...||..||.||.|||...||.||.||..| .|..|. ..|||.. ..|. .
lteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs
PP2C Protein phosphatase 2C 24-269 3.1e-82 269.0 In-house 3-251 (255) alignment 
Range on Protein: 24-269
Range on HMM: 3-251/255.0
VGSSCMQGWRVDMEDAHTHLLSL---PDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEG-NMKEAIEKGFLE-LDQQMRVDEET-KDDVSGT
||.|..||.|  |||||..| .|    .. . |||||.|||||.....| . .|....  ||.|.|. . ..|. |.||. .|.... .... ... ||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TAVVVLIKEGDVYCGNAGDSRAVSSVVGEAR-PLSFDHKPSHETEARRIIAAGGWVE-FNRVNGNLALSRALGDFAFKNCDtkpaeEQIVTAFPDVITDK
||||.||.. ..|. |.|||||| .  ..|.  |..|||||.| |..|| .|||.|. ..||||.||.||||||| .|. .     ||.|.| ||| . |
tavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsvk

LTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSICEELLTRCLAPDC
||...||..||.||.|||...||.||.||..| .|..|. ..|||.. ..|. .
lteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs
PPM_PTC7 24-269 1.5e-81 266.6 In-house 3-255 (259) alignment 
Range on Protein: 24-269
Range on HMM: 3-255/259.0
VGSSCMQGWRVDMEDAHTHLLSLP---DDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEG-NMKEAIEKGFLELDQQMRVDE--ET-KDDVSG
.|.|..||.|. |||||..|  |    .. . |||||.|||||.....| . .|....  .|.| |. . ..|. |.||.||. .. .   .  ... ||
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsG

TTAVVVLIKEGDVYCGNAGDSRAVSSVVGEAR-PLSFDHKPSHETEARRIIAAGGWVE---FNRVNGNLALSRALGDFAFKNCDTkpaEEQIVTAFPDVI
.||||.|| . ..|. |.|||||| .  |.|. .|..|||||.| |..|| .|||.|.   ..||||.||.|||.||| .|.  |   ||| |.| ||. 
stAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePdis

TDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKrDPQSICEELLTRCLAPDC
. |.....||..||.||.|||...||.||.||. |..| ||. ..|.|.. ..|...
stkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargs
0049733 PP2C-like 24-284 2.5e-56 183.5 In-house 5-231 (235) alignment 
Range on Protein: 24-284
Range on HMM: 5-231/235.0
VGSSCMQGW-RVDMEDAHTHllslpddpKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQ-KEFSEGNMKEAIEKGFLELDQQMRVDEET--KDDVSGTTA
|| ....|. |  .|||.          ....|||.|||||. ....   .|.. .... .|... ...||..| ||.......   ..  . ...||||
vgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTa

VVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVefnRVNGNLALSRALGDFAFKncdtkpaeeqivtafPDVITDKLTPD
||.|. .| .|. |.|||||.    |....|..||.|..|.| .|||.|||.|   ||.| |||.|||||. .|               ||| . .|.|.
vvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvlelepg

HeFIVLACDGIWDVMTNQEVVDFVREklaekRDPQSICEELLTRCLApdcqmgGLGCDNMTVVLV
. |..||.||.|||....|.||..|.      |.. ..|.|. ..||      . |.||.|||.|
d.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala......rggrDNiTvvvv
PPM_PTC7_SpoIIE 24-266 6.6e-48 156.5 In-house 3-223 (230) alignment 
Range on Protein: 24-266
Range on HMM: 3-223/230.0
VGSSCMQGWRVDMEDAHTHLLSL---PDDPKCAFFAVYDGHGGSKvsQYSGINLHKKVVAQKeFSEGN-MKEAIEKGFLELDQQMRVDeetkDDVSGTTA
.|.|..||.|  |||||...  .   ...   ......|||||.   ..    |.... ... | ...  .|......|.|..... .    ...||.||
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede....psssgaTa

VVVLIKEGD--VYCGNAGDSRAVSSVVgE-ArplsfdhkpshetEARRIiAAGGWVE----FNRVNGNLALSRALGDFAFKNcdtkpaEEQIVTAFPDvI
||.||   .  .|. |||||... .   .               |..|| .|||...    ..||.|.||.|.| ||. ..       ....|.| ||  
vvalidpstgklyvanaGdsppllvrd.dgg.............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd.t

TDKLTPD-HEFIVLACDGIWDVMTNQEVVDFVREKLAEKrdpqsICEELLTRCLA
 |..... .||..||.||.|||...||.||.||. | ..     ..|.||. ...
sdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDit
subfamily_PPM1D_pd Subfamily PPM1D 24-286 6.2e-40 130.2 In-house 4-307 (309) alignment 
Range on Protein: 24-286
Range on HMM: 4-307/309.0
VGSSCMQGWRVDMEDAHTHLLSLPDDP---KCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSE---GNMKEAIEKGFLELDQQMRVDEE----T---
| |.. || |  |||  .  |.  .     . ||.||.||||| . ...   .| ...  ||.|      .. |||...||.. ..|.   |    |   
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksg

KDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGE------ARPLSFDHKPSHETEARRIIAAGGWVEFN---------R----VNGN--------LAL
.   .|||| ||.|.. ..| .. |||..| .|  .      |..|  ||||.. .| .||  .|| |  .         |     ||.        ||.
llstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLav

SRALGDFAFKNCDtkpAEEQIVTAFPDVITDKLTPDHE-FIVLACDGIWDVMTNQEVVDFVREKLAEKRD----PQSICEELLTRCLAPdCQMGGLGCDN
.|.|||.   |      .| .|   |||   .|.|..| ||.|| ||.|.|.| ...|..|... . |       .|. . |... |    .   | .||
aRslGDlWsynak...sgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqr.wrskklraDn

MTVVLVGL
..|..| |
vsvivvil
subfamily_PPM1K_pd Subfamily PPM1K 24-284 1.6e-38 125.3 In-house 6-256 (263) alignment 
Range on Protein: 24-284
Range on HMM: 6-256/263.0
VGSSCMQGWRVDMEDAhTHLLSLpdDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKeFSEGNMKEAIEKGFLELDQQMRVD-----EETKDDVSGTT
||   ..| | . ||   .|. |  ||.  ..||.|||.||   ..   .|.| .   .   | .... . . |.|||....        |..   ||||
vGkdsliGkraenedr.iklkel..dpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGtt

AVVVLIKEG-DVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFN-----RVNGNLALSRALGDFAFKNCDtkpaeeqiVTAFPDVI
| |.|...| ..   . |||||.    |.|. |. ||.|..|.| .|| |||| ||.|     .||| ||..|.|||. .|.          | | |.  
atvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG........viatPetk

TDKL-TPDHEFIVLACDGIWDVMTNQEVVDFVREKlaekRDPQSICEELLTRCLapdcQMGGlgCDNMTVVLV
. |.   .  |.||  ||| .|...||. |.||      .||.   . | .  |    | |    || |.|.|
slkvdhaadsflvlitdgisfvvnsqelcdlvrlc....hdpeeaahalteqal....qygs..ednatavvv
subfamily_PPM1L_pd Subfamily PPM1L 27-250 5.7e-47 153.2 In-house 10-239 (269) alignment 
Range on Protein: 27-250
Range on HMM: 10-239/269.0
SCMQGWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVA-------QKEFSE-GNMKEAIEKGFLELDQQMRVDEETKDDVSGTT
 ...| |  |||  .    . .. .  ||||.|||||   ....   | |.. .       .|| .|  | .. ...  | .|...    ... |..|||
ysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGtt

AVVVLIKEGDVYCGNAGDSRAVS-SVVGEARPLSFDHKPSHETEARRIIAAGGWVEFN---RVNGNLALSRALGDFAFKNcdtkpaeEQIVTAFPDVITD
|.. |..| |.   | |||| |     |.| |||||||| .  | .||  |||.. |.   ||.| || ||||||. .|.       ...| | ||..| 
alialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkd.......knlviadpdiltf

KLTP-DHEFIVLACDGIWDVMTNQEVVDFVREKLAEK
.|   . ||..||.||.|| ..|.| | |..|.| | 
dlddhkpeflilasdGlwdtfsneeavrfikerlkep
subfamily_ILKAP_pd Subfamily ILKAP 27-257 5.8e-40 130.3 In-house 10-253 (293) alignment 
Range on Protein: 27-257
Range on HMM: 10-253/293.0
SCMQGWRVDMEDAHTHLLSLPDD--------PKCAFFAVYDGHGGSKVSQYSGINLHKKVVA---QKEFSE--GNMKEAIEKGFLELDQQMRVD--EETK
.. .| | .|.|||. | .| ..         . ...||.|||.||. |...  .||||...   ....|    ..| .. . | . |...     ... 
aerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakP

DDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEA------RPLSFDHKPSHETEARRIIAAGGWVEFNRVNGNLALSRALGDFAFKNCDtkpaeeqiV
    |.||.|||. .  .| .| |||.||     |.       .|. ||.| .. | .||  ||| |. .||.| |  ||..||  ||..         |
vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG........v

TAFPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSIC
.. |||   .||..  |.||||||.|.|....|||.|. . | ...| ..| 
istPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkik
Subfamily Dicty-PPM1L-like 29-252 1.8e-15 49.6 In-house 14-268 (305) alignment 
Range on Protein: 29-252
Range on HMM: 14-268/305.0
MQGWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKV-----------VAQKEFSEGNMKEAIEKGFLELDQQMRVDEETKDDVSGT
 .. |   || .   .|| .. .  .| |.|||.| . ..|.  .| . |            |.   ..    |||....|. |. .    |. .  .||
sansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnkkaGt

TA----VVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPS---------------------HETEARRIIAAGGWV-EFN--RVNGNLALSRALGD
|       | ..   .   .|.|. .| |  . | .||  . |                       ...  ||  ... . ..   .||. |  ||  ||
tlngssasvilerertivstasdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellvnrllkksrskGd

FAFKNCDTkPAEEQIVTafpdVITDkltPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRD
   |     | ... .     |...   .. .|.||| ||.|.|. .|.||..|.|.| .|  
knlkelvi.Pnndspll....vvak...anDqflvlatdGlwevlsyqdvveevkellrdkss
subfamily_PP2D1_pd Subfamily PP2D1 31-81 3.4e-08 25.6 In-house 12-62 (492) alignment 
Range on Protein: 31-81
Range on HMM: 12-62/492.0
GWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQ
 |. .|||..|      .|.. .||..|||. |.   . .  .||. .. .
rWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevllee
subfamily_KAPP-like_pd Subfamily KAPP-like 33-285 4.8e-25 81.1 In-house 9-265 (266) alignment 
Range on Protein: 33-285
Range on HMM: 9-265/266.0
RVDMEDAHTHLLSLPDDPK------CAFFAVYDGHGGSKVSQySGINLHKKVVAQKEFS----EG-----NMKEAIEKGFLELDQQMRvdeetKDDVSGT
 . ||| .     | .. |       |.|||.||| |  ... .  .| .|.. ..  |    .|     .... .|. | |.|....     . .  |.
stemedvslaiypllkekklsncsnialfavfdGhaGkGaad.aakklfpkelekllkstkqddGGdniydqskllenafkevdaklk.....dfeyeGa

TAVVVLIK-EGD---VYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEF--NRVNGnLALSRALGDFAFKNCDTKPAEEQIVTAfpdv
|| ..|.  .|.   . ..| ||| |  |   |.  ||.|||  .. | .||   |  .     |.|| ||.||||||   |. .   . |  |.     
tatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsn....

iTDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAekrdpQSICEELLTRCLApDCQMG-GLGCDNMTVVLVG
    ||| ..|...| ||.|||.. .. .. |.         |   |. .. .|  .. ..  .  ||..|..| 
.rilltpfdkflivasdGlwdvisGkdaiekvkslyd.....qqatedkmassll.etaiqsikakdnvsvivvk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 33-285 1.9e-21 69.2 In-house 8-275 (276) alignment 
Range on Protein: 33-285
Range on HMM: 8-275/276.0
RVDMEDAHTHLLSLPDDPK------CAFFAVYDGHGGSKVSQySGINLHKKVV----AQKEFS----EGNMKEAIEKGFLELDQQMRVDEETKD-DVSGT
 . ||| .     | |. .       |.|||.||| |  ... .  .|  |..       ..|    .   ..  ..  | ||    ||.. || .  |.
stemedvslaiyplldekdlsncsnialfavfdGhaGkGaad.aakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGa

TAVVVLIK-EG---------DVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEF--NRVNGnLALSRALGDFAFKNCDTKPAEEQIV
|| ..|.  .|          . ..| ||| |  |   |.  ||.||| .   | .||   |  .     |.|| ||.||||||   |. .   . |  |
tatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyv

TAfpdviTDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAekrdpQSICEELLTRCLApDCQMG-GLGCDNMTVVLVG
.         ||| ..|...| ||.|||.. .. .. |.         |   |. .. .|  .. ..  .  ||..|..| 
sn.....rilltpfdkflivasdGlwdvisGkdaiekvkslyd.....qqatedkmassll.etaiqsikakdnvsvivvk
PP2C_2 Protein phosphatase 2C 48-254 9.8e-09 27.8 Pfam-A 20-202 (212) alignment 
Range on Protein: 48-254
Range on HMM: 20-202/212.0
DDPKCAFFAVYDGHGGSKVSQY-------SGINLHKKVVAQKEFS-EGNMKEAIEKGFLEL---DQQMRVDEETKDDVsGTTAVVVLIKEGDVYCGNAGD
.. .. ..|| ||.|  | |.        . ..  .| ....... |  . ..||.. |..    |.   ..|. .|. .|| ....|..| ..... ||
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdy.atTlllavitpgeivffqiGD

SRA-VSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFnrvngnlalsralgdfafkncdtkpaeeqivtafpDVITDKlTPDHEFIVLACDGIWDVMT
... |..  ||...|. ...  .. | ...  .  . |.                                   .... | ... . ..|  ||..| ..
gaivvrdrdgevqllgepdsgeyanettfltsedaeeel...................................rirrlk.lepgdalllmTDGvsdslr

-NQEVVDFVREKLAEKRDPQ
 .... ....| |.. ....
keepfrellaelletleeeg
PP2C_2 Protein phosphatase 2C 48-254 9.8e-09 27.8 In-house 20-202 (212) alignment 
Range on Protein: 48-254
Range on HMM: 20-202/212.0
DDPKCAFFAVYDGHGGSKVSQY-------SGINLHKKVVAQKEFS-EGNMKEAIEKGFLEL---DQQMRVDEETKDDVsGTTAVVVLIKEGDVYCGNAGD
.. .. ..|| ||.|  | |.        . ..  .| ....... |  . ..||.. |..    |.   ..|. .|. .|| ....|..| ..... ||
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdy.atTlllavitpgeivffqiGD

SRA-VSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFnrvngnlalsralgdfafkncdtkpaeeqivtafpDVITDKlTPDHEFIVLACDGIWDVMT
... |..  ||...|. ...  .. | ...  .  . |.                                   .... | ... . ..|  ||..| ..
gaivvrdrdgevqllgepdsgeyanettfltsedaeeel...................................rirrlk.lepgdalllmTDGvsdslr

-NQEVVDFVREKLAEKRDPQ
 .... ....| |.. ....
keepfrellaelletleeeg
PP2C_SIG_SM00331 52-284 1.3e-10 34.2 In-house 30-215 (217) alignment 
Range on Protein: 52-284
Range on HMM: 30-215/217.0
CAFFAVYDGHGGSKVSQYSGINLHKKVvaQKEFSEGnmkEAIEKGFLELDQQMRVDeeTKDDVSGTTAVVVLI--KEGDVYCGNAGDSRAVSSVvgeARP
  ...| ||.|. . ..     |....  ....|||   |.... . .|.. ..    .... ...|... |.  ..| ..  |||||| .       . 
rlllvvaDgmGkGlaAaaassqlrtal..rellseg...eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllr...dgk

LSFDHKPshetearriiaaggwvefnrvngnlALSRALG-----DfafkncdtkpaeeqivtafPDVITDKLTPdHEFIVLACDGIWDVMTN-----QEV
| ...|                           ....||     .                   .|. . .| .  ....|. ||......      ...
lveilkd.........................vegaplGlepevs...................vdirelelek.gdllllytDGltearsekgfaeerl

VDFVREKL-AEKRDPQS-ICEELLTRCLAPDCqmgglgCDNMTVVLV
 .......  |... .. | ||||..  ..         |..|||.|
eeiledlvdseaqelaqkiveellelakgsng......eDdiTvvvv
subfamily_PHLPP_pd Subfamily PHLPP 53-246 1.2e-06 20.7 In-house 28-215 (246) alignment 
Range on Protein: 53-246
Range on HMM: 28-215/246.0
AFFAVYDGHGGSKVSQYsGINLHKKVVAQKEFSEGNMKEAIEKGFLELDQQMRVDEETkddvSGTTAVVVLIKEGD--------VYCGNAGDSRAVSSVV
| . ..||.  ...|.    .| |.|.. .   . | .| ... .|   ...  . |      |..|...||..          .   . |   ||    
alyGlfdGdrneelssl.lqrlmkdvlkeevqkdkneeeymkntllvaqrklGeaGek....lgsaallilirhdkvdPaksfsLevAsvGtlqavliRn

GEARPLSFDHKPSHEtEARRIIAAGGWV-EFNRVNGNLALSRALGDFAfkncdTKPaeeqIVTAFPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFV
|.  .||  .. ... |..||  | . . | |..|| .. .| || .      . |    .|   | |   .||.. |....  . .|.|.  .|.|. |
gkklrlsksyviekd.elkrikeakaiitednkingviestrllGytf.....lfP....vvlPkphvrevlLteqdellivGnkalWevlsideaveav

REK
|..
rke
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 54-192 9.2e-21 67.6 In-house 22-185 (292) alignment 
Range on Protein: 54-192
Range on HMM: 22-185/292.0
F-FAVYDGHG--GSKVSQYSGINLHKKVVAQKEfSEGNMKEAIEKGFLELDQQMRVDEETKDDVSGTTAVVVLIKEG-DVYCGNAGDSRAVSSV-----V
|  ||.||||  | ||.|..  .| ....        .. ||. .. |..  ...     .   ..|..|   ....  ..  | |||||.         
flaavldGhGvnGdkvaqlaedtlevelleltr.qlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsd

GEARPLSFDHKPSHETEARRIIAAGGWVE-----------FNRV------NGNLALSRALGDFAF
 | .||| ||||.   | .|| .||| ||             ||      .|.|||||||||| .
yeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhl
subfamily_PDP_pd Subfamily PDP 75-256 1.1e-24 80.3 In-house 101-321 (398) alignment 
Range on Protein: 75-256
Range on HMM: 101-321/398.0
HKKVVAQKEFSEGNMKEAIEKGFLELDQQMRV-----------DEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVG-----EARPLSFDHKPSH
.|.. .. | . ...|||..|.||.||....            .|...  .||..|...||.. ...  |.||.|||  |.      ||..|| |.  . 
skylqelleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadn

ETEARRIIAAGG------WVEFNRVNGNLALSRALGDFAFKNCD---TKPAEE------Q--------IVTAFPDVITDKLTPDHEFIVLACDGIWDVMT
| | .|| ..         .  .|. |.|. .|| ||. .|       |. |.      .         .|| |.|.. ||...  |.||| ||.||...
eeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdlls

NQEVVDFVREKLAEKRDPQSI
|.|||. | | ||.| . ...
neevvslVgehlakkkekepv
subfamily_PPM1H_pd Subfamily PPM1H 89-165 2.4e-16 52.5 In-house 136-210 (404) alignment 
Range on Protein: 89-165
Range on HMM: 136-210/404.0
MKEAIEKGFLELDQQMRVDEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPshETEARRI
.. |.|. |||.|.|.. ..|.  .  | ||.|.|. .| .|  |||||||. .  .| .|||.|. |  ||| .|.
viGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftP..eteRqRl
subfamily_TAB1_pd Subfamily TAB1 105-234 5.2e-14 44.8 In-house 119-260 (333) alignment 
Range on Protein: 105-234
Range on HMM: 119-260/333.0
RVDEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSV---VGEARPLSFDHKPSHETEARRIIAAG---GWVEFNRVNGNLALSRALGDFA----FKN
|. | ...   ||||||.||   ..|  |.|||||.        . . || ||.   | |  |.   |     .. |.. |.    |..||.     .|.
rlqeleeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykd

CDT-KPAEEQIVTAFPDVITD-KLTPDHEFIVLACDGIWDVM
 |  . |... | | ||..   ....   |.||  ||.   .
vdilssakgePviaePdiqgaypiddityflvlmSdGvyktL
subfamily_PP2D1_pd Subfamily PP2D1 107-252 1.3e-17 56.7 In-house 168-311 (492) alignment 
Range on Protein: 107-252
Range on HMM: 168-311/492.0
DEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVE----FNRVNGNLALSRALGDFAfkncDtkPAEE
| |   . .  .  | |.. | .|  |||. .||    |.|  |  .| |  . | .|.  ||. |       .||| |   | || .     |  |  .
dseeGlekesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG....d..pkLk

QIVTAFPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRD
. |   | ... ||.    |.|||  |.|.|....||.  |.. ||  ..
ksvipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyks
subfamily_PPM1G_pd Subfamily PPM1G 109-286 5.3e-73 239.6 In-house 290-470 (473) alignment 
Range on Protein: 109-286
Range on HMM: 290-470/473.0
ETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVE-FNRVNGNLALSRALGDFAFKNCDTKPAEEQIVTA
|..   |||||||.|.|| ...  ||||||.| |  |.|  || ||||  |.|..|| .||| |.   |||| | |||||||.|.|.  . |..||...|
eepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisA

FPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDP--QSICEELLTRCLAPDCQMGGLGCDNMTVVLVGL
.||. . .||...||.||||||||.||. ||||||||.||.....   ..|.||||  ||||| .  | |||||||..| |
lPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
subfamily_PPM1H_pd Subfamily PPM1H 175-251 1.3e-10 33.6 In-house 275-355 (404) alignment 
Range on Protein: 175-251
Range on HMM: 275-355/404.0
NRVNGNLALSRALGDFAFKNCDTKPAEEQIVTAFPDVITDKLTP----DHEFIVLACDGIWDVMTNQEVVDFVREKLAEKR
.|. . .. .| |||   | .||.     .....|.| .  ||     . . ..|| ||.|||..|.||   ||| |..  
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 212-247 3.8e-06 19.6 In-house 239-273 (292) alignment 
Range on Protein: 212-247
Range on HMM: 239-273/292.0
ITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREkL
.  .|  | .|.||| ||. ||..|.||| .. .  
lekeldsddaflvlasdGvldvllnaevvlllak.s
PPM_PTC7_SpoIIE_motif 221-284 2.1e-10 34.1 In-house 13-78 (81) alignment 
Range on Protein: 221-284
Range on HMM: 13-78/81.0
EFIVLACDGIW-------DVMTNQEVVDFVREKlaEKRDPQSICEELLTRCLApdcQMGGLGCDNMTVVLV
. ..|..||..       ......|.......   |....|.....|. ..|.   . .|   |..|....
dvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle...ngsgereDDitllvl
PPM_PTC7_motif 224-269 4.6e-19 61.7 In-house 1-47 (51) alignment 
Range on Protein: 224-269
Range on HMM: 1-47/51.0
VLACDGIWDVMTNQEVVDFVREKLAEKR-DPQSICEELLTRCLAPDC
.||.||.|||...||.||.||. |..|. .||...|.| ...||. .
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargs