Gene R03D7.8 in Caenorhabditis elegans

Synonym: CELE_R03D7.8, CELE_R03D7.8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP165_AA protein Get Run
CeleP165_AA_298-595 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 299-593 6.1e-50 163.3 In-house 11-322 (473) alignment 
Range on Protein: 299-593
Range on HMM: 11-322/473.0
GWGHTLWSTVRTINSPYDLLYRMIEHGPYQYPFTALELLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSG
 . . |   . .|. ..  |...|||  ... ... .|| |..|..  ...||.||.... |.||||| | ..|| | |.. |.|| .|..||| . | |
pvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrG

eSGSVECLALICSLKCRFPKHVFILRGEPE----TSPFRMSTRLHPVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAE
 . |.|.| |. .||...|..||.|||  |    .  ..    ..   .. . . . . . ..|.||.||. .| |  | || ..    |... || . .
.pdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleip

HMNAVERHIIFNqPSNRVRM-------YRPNPNTEGDWFGKQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNR------LINLWSAPGY---GSDFGAI
. ...      . | .           ....|   | .||..||.. .|   .....||   || || ......      .| ..||| |   |   .|.
ddgllldllwsd.PweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAv

LSISKDLvITPILME
| |..|| |..|...
lvidedl.isfiqfd
0049330 Metallo-dependent phosphatases 304-593 4.7e-49 160.3 In-house 3-297 (309) alignment 
Range on Protein: 304-593
Range on HMM: 3-297/309.0
LWSTVRTINSPYDLLYRMIEHGPYQYPFTALELLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGeSGSV
|.... ...  ..|| ..||.  ... ..  ||| |....   . .||.||.....|.||||| | . || | |.. |.|| .|..||| . | | . |.
lldpllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrG.pdsl

ECLALICSLKCRFPKHVFILRGEPETSPFR----MSTRLHPVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAV
|.| |. .||...|..||.|||  |.   .        ..      .   . ..  ..|.||.||...| |  |.|| .   ..|..| ||..  . . .
evlllllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgll

eRHIIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGY---GSDFGAILSISKDLVITPILME
  ......|.. .....|||.  | .|| .||.| .|    ...|||  .|. |||......|| ..||| |    ...||.| |..||||...|.|
.cdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfe
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 316-574 1.9e-20 66.3 In-house 5-268 (307) alignment 
Range on Protein: 316-574
Range on HMM: 5-268/307.0
DLLYRMIEHGPYQYPFTALELLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCR
|  |..|. | ..  .|  |.  .  |.   .. | .|..|.    |.||. |.. ||   . | | ||    .| |  .| |   |.||. |. . |  
drhyqviqagvhkiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgll.slecilllftykic

FPKHVFILRGEPETSPFRMSTRLH-------PVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVeRHIIFNQP
.|... .|||. | .       ..       |     . . ..|    .| .|.|   .|... |.|| .     .    .|.       |   ... .|
ypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgiv.ndmlwadp

SNRVRMYRPNPNTEGDWFGKQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSD
   |  ..      |  || . .   ||    ...|| .  .  ||      .|| ..||| |   
dpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnf
0053225 Metallo-dependent phosphatases 317-592 1.2e-43 142.8 In-house 8-288 (293) alignment 
Range on Protein: 317-592
Range on HMM: 8-288/293.0
LLYRMIEHGPYQYPFTALELLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGEsGSVECLALICSLKCRF
|| ..||.  ... ... ||| |..|.   . .||.||.....|.||||| | ..|| . |.. |.|| .|..||| . | |   |.|.| |. .||...
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGp.dslevlelllalklly

PKHVFILRGEPETSPFRM-----STRLHPVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVERhIIFNQPSnR
|..|..|||  |.   ..     .  |.  . ...   . .   ..|.||.||...| |  |.|| .   ..|... ||   .. ...   . .. |. .
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllld.llwsdpd.l

VRMYRPNPNTEGDWFGKQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGY---GSDFGAILSISKDLVITPILM
.. . |...  | .|| .||.| .|.   . .|||  .|| ||||.....|. ..||| |    ...||.| ....||....|.
wsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklf
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 330-593 1.4e-29 96.2 In-house 6-299 (302) alignment 
Range on Protein: 330-593
Range on HMM: 6-299/302.0
PFTALELLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLT------------GWpPHNRILFLGGILDSGESgSVECLALICSLKCRFP
 ..  |||.| |.   .. .| .| .| . .|..||| |.. || | |.              ..  ... .|||  .| |.  |.||..|. .||  .|
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsk.sieciclvfalkvlyp

KHVFILRGEPETSPFR--------MSTRLHPVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVERHIIFNQPS
..  .|||. ||            . .|| .  .  .    . . ..||.||..|. .| |. | || ..   .|... ||..    ... . ..| .| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

NR--VRMYRPNPNTE-------GDWFGKQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDF---GAILSISKDLVITPILME
.   . . . .|. .          | . ||.  ||    ....|.   .| |.    ...|. ..|||.|  .    ||.| .  .  .. . . 
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 331-593 1.3e-29 96.4 In-house 6-298 (302) alignment 
Range on Protein: 331-593
Range on HMM: 6-298/302.0
FTALELLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLT------------GWpPHNRILFLGGILDSGESgSVECLALICSLKCRFPK
..  |||.| |.   .. .| .| .| . .|..||| |.. || | |.              ..  ... .|||  .| |.  |.||..|. .||  .|.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsk.sieciclvfalkvlypt

HVFILRGEPETSPFR--------MSTRLHPVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVERHIIFNQPSN
.  .|||. ||            . .|| .  .  .    . . ..||.||..|. .| |. | || ..   .|... ||..    ... . ..| .| .
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

R--VRMYRPNPNTE-------GDWFGKQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDF---GAILSISKDLVITPILME
   . . . .|. .          | . ||.  ||    ....|.   .| |.    ...|. ..|||.|  .    ||.| .  .  .. . . 
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 331-588 1.3e-26 86.3 In-house 16-282 (290) alignment 
Range on Protein: 331-588
Range on HMM: 16-282/290.0
FTALELLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETS
|.  ..| ..|.    .   |.||..|| |...||| |.  .| |...  | ||. . ||||  .| |   |.|   |.  .| |..|.| .|||. |. 
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgak.slevslllfcykiryskkvhllrgnhevr

PFRMSTRLHPVITRAVQSCIKRM----CTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHM-NAVERHIIFNQPSN-RVRMYRPNPN-TEG
       ..  ..|  .| . ..     . ... | .|. .| .. | |. |     .. | .| .  .  . .   ... .|.. .   .. |   .  
kvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqrais

DWFGKQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGY---GSDFGAILSISKDLVIT
  |||...   .|    ....|       |.   ....|. ..||| |    .. |||. .|. | ..
vvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslels
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 331-383 8.7e-07 21.3 In-house 11-63 (339) alignment 
Range on Protein: 331-383
Range on HMM: 11-63/339.0
FTALELLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWP
| | ||  |   .   .  || .|..|| | |.|||.|.. ||   |.. |||
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 333-383 1.4e-07 24.0 In-house 11-61 (317) alignment 
Range on Protein: 333-383
Range on HMM: 11-61/317.0
ALELLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWP
. ||. |   .   . .||  |..|| .|..||| |.. ||   |.| |||
ekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_PPP1C_pd Subfamily PPP1C 334-590 1e-41 136.0 In-house 15-274 (282) alignment 
Range on Protein: 334-590
Range on HMM: 15-274/282.0
LELLCLFEETAFkmAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFR
.| |.   ....   ..| ||..|| ....||| |.|||| | .. .| ||... ||||   | |.  |.| ..|. ..|...|...|.|||  |..   
ieallkkareil..lsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkq.sletivlllaykikypenlfllrGnhesasin

MSTRLHP----VITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEhMNAVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQ
.   ..       .  .  ... .  ..|.||.. . .| |. |.|| ...  .|... ||.. . .... . ...  | ..|  .  |       |||.
riyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevp.ekgllcdllWsdpdkevlgwsendrGvsftfgkd

AVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSD---FGAILSISKDLVITPI
.|.. .. .  ....|.   |  ||    ...|. ..||| | .     ||.||....|...  
vvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfq
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 334-587 1.1e-31 102.9 In-house 13-274 (287) alignment 
Range on Protein: 334-587
Range on HMM: 13-274/287.0
LELLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFR
 ..| ..|..   .   |.||..|| ||..||| |.. || |...  | .|. . ||||  .| |   |.|   |. ||| ..||.| .|||. |     
kdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGak.slevslllfslkiaypkkvhllrGnhevkkin

MSTRLHPVITRAVQSCIKR----MCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHM-NAVERHIIFNQPSNRVRMYRPNPNT-EGDWFG
    ..  ..|  |. . .    . ...|. |...| .| .. | || ..    .. | .| |     . .   ... .|..    ...|        ||
klyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfG

KQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYG---SDFGAILSISKDLVI
|. |   .|    ....|    . .||    ..||. ..||| |    ...||.. .|| | .
kkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslel
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 334-587 1.8e-30 99.1 In-house 11-269 (281) alignment 
Range on Protein: 334-587
Range on HMM: 11-269/281.0
LELLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFR
 |.  .  |.   ..|| .| .|.. |.|.||. ... ||.| ..| | .|.....|||  .| |   |.|.| |. .|| |.......|||. |..   
eeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpq.slevlillftlkiryrdrivllrgnheiasvn

MSTRLH----PVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMnAVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQ
    ..      .   .   ..|   ..|..| | | || .. |.|| .  . ...   .|.   .   .   ... .|.|.|  ..      .  |||.
kiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldr.GlviDllwadpdnkveewkassrGssftfGkn

AVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDF---GAILSISKDLVI
 |. .||    ...||.   |  ||      .|| ..|.| | . .   .|.| . ..| |
vvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgi
PP2Ac_SM00156 336-595 1.6e-44 144.9 In-house 6-270 (271) alignment 
Range on Protein: 336-595
Range on HMM: 6-270/271.0
LLCLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESGsVECLALICSLKCRFPKHVFILRGEPETSPFRMS
.| | ||..  . .|..|....| .||.||| | . || | |.|.| ||.....|||  .| |. . .|.. |...|| ..|..|..|||. |.|.  . 
vlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqs.iEvillLfalkilypekvvLLRGnHEsssvnki

TRLH----PVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRpVTAEHMNAVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQAV
  .       ... . .......  .|.||......| . .|.||....  .|..| | | ... . .   .... |....  ..|.    . .||..||
ygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr.vkekpeegllidllwsdpeqkekgfqpskrglsvvFgedav

KRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSD---FGAILSISKDLVITPILMEKQ
|. .|. . .. ||.   |. ||  .....|. ..||| | .     .|.|...|.| .. .....|
keflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 337-588 4.2e-31 101.3 In-house 32-287 (299) alignment 
Range on Protein: 337-588
Range on HMM: 32-287/299.0
LCLFEETAFkmAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMST
||    ..|  |...|||..|| | | ||| |.|.|| | .. .|.||.   ||||  .| |    .| ..|.   | ..|.. |.|||. |        
lcavaksvf..asqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrq.nlelitlllcfkikyperffmlrgnhecpainrvy

RLHPVITRAVQ-----SCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHmNAVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQAV
 ..    .  .     | ..   . ||.. .||  .|... |.|| ...   . .| ||       ...  ... .| . |. ...|       ||.. |
gfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppn.pslgidllwadpdqsvkdwlanvrgvsyvfgqdvv

KRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFG---AILSISKDLVIT
.  ..    ... | .  |  ||    ...|. ..||| |  .|    ||. . ..|| |
advisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvct
subfamily_PPP7C_pd Subfamily PPP7C 337-584 1.6e-11 36.6 In-house 39-324 (383) alignment 
Range on Protein: 337-584
Range on HMM: 39-324/383.0
LCLFEETAFKMAEEPSLLQIE----ADITVIGDIRGRYADLHRWLQLTGWPP-HNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSP
| .. |.. .. . |.. ...     ..|| ||. |.  ||   |   | |  .|  .| | ..| |.. ||| | ....|   .||.|.. ||. | . 
llilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGke.sveillillalllvypkevylnrGnhedhi

FRMST-------RLHPVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIR-------EKGHIHHLFRPVTAEHM--------NAVER--------
. .           ..| .. .   .. . . .|.|..| ...| |. |.| .         |. ... ..|| . | .        ..|.         
lnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktdlelldkiersklvsvlrpplkegeeaekekeessvkvdkeewrqv

-HIIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGY---GSDFGAILSISKD
  |..  | ..           | .||    |.  .  . ...||     | ||  . ..... ..||  |   ||. || . ..||
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkd
subfamily_PPP3C_pd Subfamily PPP3C 338-489 4.7e-25 81.3 In-house 48-202 (452) alignment 
Range on Protein: 338-489
Range on HMM: 48-202/452.0
CLFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPE----TSPFR
 ..||.|  . .|..||..|| ||||||| |.. || . ... | | . . ||||  .| |   |.||.  . .||. .|...|.|||. |    |. | 
kiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyf.siecvlylyalkiaypstlfllrGnhecrhlteyft

MSTRLHPVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFR
. . ..   . .|   . .    .|.||.. .  | |. |.|| |.. . |..| |
fkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldr
subfamily_PPP6C_pd Subfamily PPP6C 339-581 1e-26 86.8 In-house 23-267 (290) alignment 
Range on Protein: 339-581
Range on HMM: 23-267/290.0
LFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTR-
| .  .  . || ..  ... .|| ||| |.. ||.  .. .|  |... .|||  .| |   |.| .... .|| ..|... .|||. |.         
lcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyy.sletftrlltlkakypdritllrgnhesrqitqvygf

LHPVITRAVQSCIKRMCTH----MPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVeRHIIFNQPsNRVRMYRPNPNTEGDWFGKQAVKR
 .  ...  ..   . ||.    .. |||| ..|| |. |.|| ..   .|. . |     |  |.   ... .| . |  .   |   |  ||.. .| 
ydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgaf.cdlvwsdp.edvetwavsprgagylfgskvtke

ACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFGAILSI
 ..    ....|    |  |.   ....|. .|||| |    | . ||
fvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasi
subfamily_PPPLV_pd Subfamily PPPLV 339-571 1e-11 37.7 In-house 5-263 (290) alignment 
Range on Protein: 339-571
Range on HMM: 5-263/290.0
LFEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQL---TG--WPPhNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFR
| . .  ..|.|  ||.... . |.||. | | ||  . .    ||    |   .||||  .| |.  ||| .| . .||  .| .|..|||. |     
lcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltp.asllflgdyvdrgdf.sveliayllalkvlypskvlllrgnhelesvq

MSTRLHPV-------ITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLF---RPVTAE-HMNAVERHIIFNQPSNR-----------
 |   .             |   .. .   .| ||.| . |. |..|    |  ...|  .      .  . .   .   |....|..            
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

VRMYRPNpN--TEGDWFGKQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGY
   . .| .   .|  |...|...  | . .. ..|       |.    . ||. ..|.  |
neGfvdn.drrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssry
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 340-588 4.2e-38 124.1 In-house 33-287 (298) alignment 
Range on Protein: 340-588
Range on HMM: 33-287/298.0
FEETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLH
 |..   ... .||....| |.| ||| |.|.|| | .. .|.||..  ||||  .| |.  ..| . |. . | ..|...|.|||. |..       ..
ielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrq.nlevivlllaykvkypnnffllrGnheceainrvyGfy

PVITRAV-----QSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMnAVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRA
  ..|        .  . .  ..|..|.||. .| .. |.|.....  ....| ||. ...  ...  ...  |.| |. . .|    .  ||...||  
eeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskee.slaidllwadpenavkgwaensrGvsvvfGedvvkdl

CKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFG---AILSISKDLVIT
..    ....|.   |  ||    ...|. ..||| |  .|    |.......||..
lekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvs
PPP_3 342-589 7.3e-37 119.8 In-house 13-266 (271) alignment 
Range on Protein: 342-589
Range on HMM: 13-266/271.0
ETAFKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMS----TR
...  . .|..|..|.|..||.||| |.. || .  . .| .|... ||||   | |.  |.|.| |...||...||.|..|||  |..         . 
klkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkk.slEvlllLlalkikypkevhLlRGnhEsrqinkvYgFkke

LH-PVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVERHIiFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACK
.   . .  | . .... . .| ||.| ..|| |  |.|| |..  .|..| |. . ..  .. ..  . ..... .......   | .||...... ..
vlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll.lssdpekeeglenskrGagllFgpdvteefle

ATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGY---GSDFGAILSISKDLVITP
... ...||    .. ||  . ..... ..||| |   .|. ||||.....|  ..
knkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsef
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 345-589 5.2e-30 97.8 In-house 17-268 (284) alignment 
Range on Protein: 345-589
Range on HMM: 17-268/284.0
FKMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLHPVITR
  . ..| |..... | . |||.|...|| | ..  |.| .   ||||  .| |.   .| . |. . |  ||.|.|.|||. | |       ..    |
sifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkh.cletilllfaykvifpnhffmlrgnhecslinkiygfyeecqr

-----AVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACKATR
     .|   .. . . ||..|..|. .|... | | |...  ... . ||.     |..   |.. .|.|  . . ||       || .|...     .
rynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrlq

CNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFG---AILSISKDLVITP
 ....| .  |  ||    | ||. ..||| |  .|    |.. . |.|| . 
idlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsf
PPP_1 346-576 8.4e-31 100.2 In-house 16-256 (264) alignment 
Range on Protein: 346-576
Range on HMM: 16-256/264.0
KMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMS----TRLH-P
 . .|. ||.....|||.||| |.. || .  . .| .|... ||||   | |.  |||.| |...|| ..||..|.|||  |..         . .   
llnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkd.SvEilllLlalklkypkelfllRGNHEsrqvtkvygFkkEvlkk

VITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVERH------IIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRA
. .  . . .. .   .| ||.| ...| |  | ||...   .|... |  .  .  ... .      | ....... .. . ..   |  |||..... 
kyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagylfgkdvtekf

CKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFG
....  ...||    .. ||  . ..... ..||. | . ..
lqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegs
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 346-577 5.2e-28 91.3 In-house 21-254 (280) alignment 
Range on Protein: 346-577
Range on HMM: 21-254/280.0
KMAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESGsVECLALICSLKCRFPKHVFILRGEPETSPFR------MSTRLH
 . ||  | . || | |||||. .| |. | ..| |  | ....|||  .| |  | .| | |.  || |.  ....|||. ||          .  . .
ifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqg.ievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqyk

PVI--TRAVQSCIKRmcthMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMnAVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACKA
  .     .|||..|    ||....| | ||... |.|| . .   |. . ||.      ..   .....|.|.   .  .       |||  |..|||.
ygvglwwdfqscfnr....mpmsgliskrvlcmhgglspelinldtirniprpcepldr.gllidllwsdptnkgegwfhsirgisymfgkgvveqacks

TRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFGA
   ...||..  |  ||      ||| ..| | | ..|  
leidliirahqvvqdgyemmagrrlitvfsvpnycaqftn
subfamily_PPP5C_pd Subfamily PPP5C 346-577 1.5e-16 53.3 In-house 49-287 (322) alignment 
Range on Protein: 346-577
Range on HMM: 49-287/322.0
KMAEEPSLLQIEA----DITVIGDIRGRYADLHRWLQLTGWPP-HNRILFLGGILDSGeSGSVECLALICSLKCRFPKHVFILRGEPETSPFR----MST
 . ..|||..|.      .|| ||| |.. ||   ..| | |  .|  || |  .| | | |||.. .. ..|  .|.|.|. ||. |..       .. 
llkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrG.sfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfeg

RLHPVITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGF-SPMIREKGHIHHLFRPVTAEHMNAVeRHIIFNQPSNRVRMYrPNPNTEGDWFGKQAVKRAC
  .   |..|    ... . .|.| .| ..|| |. |. |       ..... |     . ...  .... .| ..  .  |     |  || .  |. .
evkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegll.vellwsdpqeanGrs.pskrGvgvqfGpdvtkkfl

KATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFGA
|  . ...||       ||    . .|| ..||| |  . | 
kennleliirshevkeeGyevehdGklitvfsapnycdqmgn
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 347-586 1.1e-33 109.6 In-house 22-266 (280) alignment 
Range on Protein: 347-586
Range on HMM: 22-266/280.0
MAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLHPVIT---
.. . ......| ..| ||. |.|.|| | .. ...|| .  ||||  .| |.   .| . |. . | |.|.. .||||. |.        ..  .    
ltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrq.qlevillllaykvrypnnflilrgnhevisinrkygfkdevkrry

-RAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHmNAVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACKATRCNV
  |. . .. .  ..|..|...  .| .. |.|. ..   .. .| ||  .|. ....  ... .|.|.|  .  |.      ||.. ||  ..    ..
slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsed.eclamdllwadpenkvtgwaensrgvsvifganvvkdltekldidl

MIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFG---AILSISKDLV
..||.  |  ||    ...|. ..||| | ..|    |.| ... |.
iarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderli
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 347-593 3.8e-33 108.1 In-house 24-281 (284) alignment 
Range on Protein: 347-593
Range on HMM: 24-281/284.0
MAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWP------PHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLHP
. .|.  |.||| ....||| |.. ||   |.| |||       ... ||||  .| |   |.| ..|. ..| ..|..||.|||. |. |  |   .. 
fwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpf.sievitllfayklllpdkvfllrgnhesrpvnmqygfyl

VITR----AVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNaVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACK
   .    |.  ...     ||..|...| .. .. | |  . .   ...| ||.    .  |   . . .|...| .|.  |   |  ||..|||. .|
eckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdig.viadltwadpeaevegykesprgagkvfgakavkeflk

ATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDF---GAILSISKDLVITPILME
  . ....|    |  ||    ...|. ..||| |  ..   .|.|.....||..  ...
kfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_PPP4C_pd Subfamily PPP4C 347-581 2.6e-31 101.9 In-house 32-268 (288) alignment 
Range on Protein: 347-581
Range on HMM: 32-268/288.0
MAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRL-HPVITRA
. ||  . .... .|| ||| |.. || . ....|  |... |||| ..| |   |||.. |. .||.|.|... ..||. |.     .  . . .. . 
lveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfy.svetfllllalkvrypdritlirgnhesrqitqvygfydeclrky

VQSCIKRMCTH----MPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVeRHIIFNQPSNRVrMYRPNPNTEGDWFGKQAVKRACKATRCN
 .. . |.||.    ...|||| .....|. |.|| |..  .|  . |     |  ..   ... .| .    .   |   |  ||...|.. ..|   .
gsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegpl.cdllwsdpedae.gwavsprgagylfgsdvveqfneandie

VMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFGAILSI
...|    |  ||   .|.... .|||| |    | . .|
licrahqlvmegyklhfnekvltvwsapnycyrcgnvaai
subfamily_PPP2C_pd Subfamily PPP2C 347-579 2.5e-25 82.3 In-house 33-267 (290) alignment 
Range on Protein: 347-579
Range on HMM: 33-267/290.0
MAEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLH-----PV
...|  . .... .||.||. |.. ||   ... |  |.   ||||  .| |   |||...|. .|| |... . ||||. |.        ..       
lskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyy.svetvtllvalkvrykeritilrgnhesrqitqvygfydeclrky

ITRAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVeRHIIFNQPSNRVRmYRPNPNTEGDWFGKQAVKRACKATRCN
 . .|   .  .  ..|..|.. . ..... |.||.|    .|..| |     |  ..   ... .| .|   .   |   |  |||.  ..  |.   .
gnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegpl.cdllwsdpddrgg.wgisprgagytfgkdisekfnktnglt

VMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFGAIL
...| .  |  ||  ....... ..||| |    |   
liarahqlvmegynwshdrnvvtifsapnycyrcgnqa
subfamily_PPZ_pd Subfamily PPZ 348-588 5e-26 84.9 In-house 42-287 (300) alignment 
Range on Protein: 348-588
Range on HMM: 42-287/300.0
AEEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLHPVITRAVQ
  .|.||..   . ..||..|.|||| | .   |.|| .  ||||  .| |.  |.| . |.   | ..|. .|.|||. | .       ..    | ..
laqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkq.sletillllcykikypenffllrgnhecanvtrvygfydeckrrcn

SCIKRM----CTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVErHIIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACKATRCNVM
  | .        .|.|||.   ...|. |.||..     |.|. ||     .  ..  .....|..    .  |       . | |...  .    ...
ikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglin.dllwsdptdssnewednergvsycynkvainkflnkfgfdlv

IRGQSYVPYGYLPCWNNRLINLWSAPGYGSDF---GAILSISKDLVIT
 | .  |  ||    .  |. ..||| |  .|   ||..|.|. |. .
crahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcs
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 349-577 5.7e-25 81.2 In-house 41-274 (297) alignment 
Range on Protein: 349-577
Range on HMM: 41-274/297.0
EEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLHPVITRAVQS
 . |.....| | | |||.|.. || | ..  ||||    ||||  .| |   |.| . |. . | .||  .|.|||. |         ..    .  ||
aqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrf.sietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqkryqs

C-----IKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRP-VTAEHMNAVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACKATRCNV
      .. .   .|.. .| . .|... |.||.. ..  .. | .   . |  . .   ... .|   .  .  |    |  ||..|| . |   . ..
vrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegkerlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldl

MIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFGA
. | .  |  ||      .|. ..||| |  .|  
vcrahqvvqdgyeffagrklvtifsaphycgqfdn
subfamily_PPG1_pd Subfamily PPG1 349-581 7.8e-22 70.9 In-house 32-279 (300) alignment 
Range on Protein: 349-581
Range on HMM: 32-279/300.0
EEPSLLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLHPVITRA---
.|  . .|.. .||.||. |.. |.   ... |  |    ||||  .| |   ||| ..|.  || |.|  . .|||. |.     .  ..    |    
kesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrgly.svetisllivlklrypsritllrgnhesrqitqvygfyteclrkygg

---VQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVErHIIFNQPS-----------NRVRMYRPNPNTEGDWFGKQAV
   |   .  .  ..  |||| ... .|. |.|| ..    |. | |     .  |.   ... .|            .  . ..  .   |  .||. |
nsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegala.dllwsdpeennnptldhpdregqhfvvsqrgagysygkdvv

KRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSDFGAILSI
..  .    | .|| .  .  ||   ..|.|  .|||| |    |   ||
ekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasi
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 353-574 8.8e-24 77.6 In-house 2-232 (263) alignment 
Range on Protein: 353-574
Range on HMM: 2-232/263.0
LLQIEADITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGEsGSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLHPVITR--------
||...| | . || .|.| || | ..  |   . . ||||  .| |   |.| . |. |||  .|.....|||. |         .|  . .        
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgg.hslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevy

-AVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVERHIIFNQPSNRVRMYRPNPN-TEGDWFGKQAVKRACKATRCNV
 .|   .... ..||..||. | .|... | || ..    |. .  |. . .   .   ... .| .  . . ||   .  . |||. |   ||    ..
esvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidl

MIRGQSYVPYGYLPCWNNRLINLWSAPGYGSD
..| .  | |||    . ||| ..||  |  .
ivrahqvveygyaffadrrlitvfsasryqie
PPP_4 360-547 3e-26 85.7 In-house 1-194 (197) alignment 
Range on Protein: 360-547
Range on HMM: 1-194/197.0
ITVIGDIRGRYADL-HRWLQLTGWPP-HNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRL-HPVITR---AVQSCIKRM
.||.||| |.. ||  . |.. | |. .....|||   | |.  |.|.| |...||...||.|..|||  |..         . |...    . . ....
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkd.slevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdv

CTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVERHI-IFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACKATRCNVMIRGQ
 . .| ||.| ..|| |. | |. ...  .|... |... .... . ... ....|... ...... .  | .||...... ..... ...||. 
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirsh
PPP_2 360-546 9.6e-25 80.4 In-house 1-194 (198) alignment 
Range on Protein: 360-546
Range on HMM: 1-194/198.0
ITVIGDIRGRYADLHRWLQLTGWPPHNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMS----TRLH-PVITRAVQSCIKRMC
.||.||. |.. || .  . .. .|... ||||  .| |.  |.|.| |...||...||.|..|||. |..         . .   . ...| . .... 
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkk.slEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevf

THMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVERHI---IFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACKATRCNVMIRG
. .| ||.| ..|| |  |.|. |..  .|..  |... .. ......     ...|... ......    | .||...... ..... ...|| 
elLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRa
PPP_5_Dcr2 360-547 1.6e-22 73.5 In-house 1-196 (199) alignment 
Range on Protein: 360-547
Range on HMM: 1-196/199.0
ITVIGDIRGRYADLHRWLQLTG-WPP-HNRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLHPVITR-----AVQSCIKR
.||.||. |.. ||  .|  .|  |. .....|||   | |.. |.|.| |...||...||.|..|||  |..         . . .      . . ...
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkd.slevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsd

MCTHMPFAAIIGKSVLAVYSGFSPMIREKGHIHHLFRPVTAEHMNAVERHI-IFNQPSNRVRM-YRPNPNTEGDWFGKQAVKRACKATRCNVMIRGQ
. . .| ||.| ..|| |  | || |..  ..... |... .  . ..... ....|....     ..   .| .||...... .. .. ...||. 
vfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirsh
Metallophos Calcineurin-like phosphoesterase 360-430 1.1e-07 25.3 Pfam-A 3-78 (200) alignment 
Range on Protein: 360-430
Range on HMM: 3-78/200.0
ITVIGDIRGRYADL----HRWLQLTGWPPHNRILFLGGILDSGEsGSVECLALI--CSLKCRFPKHVFILRGEPETS
|.||||. | ..||    ...|.. . .. . .|||| . |.|   | |.|||   ..|| ..|..|| |||  | .
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgd.wssetlalldylvlklllpipvfllrGNHesd
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 386-593 6.1e-26 84.3 In-house 101-313 (317) alignment 
Range on Protein: 386-593
Range on HMM: 101-313/317.0
NRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLHPVITR----AVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREK
.. ||||  .| |   |.| . |. .|| ..|..||.|||. |. |  ..  ..  ...    |.  . . .   .|..|...| .| .. | |  . . 
kkylflGdyvdrGpf.sievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

GHIHHLFRPVTAEHMNaVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGSD---FGAI
  ...| ||.    .  |   . . .| ..|..|.. .   |  ||..|||. .|  . ....|.   |  ||    . .|. ..||| |  .    .|.
kqldklkrpldipdvG.vladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

LSISKDLVITPILME
||. |.|.|.  ...
lsvdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 386-588 1.8e-16 53.2 In-house 120-327 (339) alignment 
Range on Protein: 386-588
Range on HMM: 120-327/339.0
NRILFLGGILDSGESgSVECLALICSLKCRFPKHVFILRGEPETSPFRMSTRLHPVIT----RAVQSCIKRMCTHMPFAAIIGKSVLAVYSGFSPMIREK
.| ||||  .| |   |.| . |. .||  .| ....|||. |.     |  ..  .       .  |.. |   .||.|.| ....... | |  .   
krylflgdyvdrgpf.smevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsf

GHIHHLFRPVTAEHMNaVERHIIFNQPSNRVRMYRPNPNTEGDWFGKQAVKRACKATRCNVMIRGQSYVPYGYLPCWNNRLINLWSAPGYGS---DFGAI
 ..  . ||.    .  |   . . .|    . |.|        ||  |..   |    ...|||.  |  ||      ||. ..||| |     .  |.
nqfsvfkrpleipdvg.vltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaav

LSISKDLVIT
.|| | | |.
fsidkklkis