Gene R08C7.8 in Caenorhabditis elegans

Synonym: CELE_R08C7.8, R08C7.8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf3
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP171_AA protein Get Run
CeleP171_AA_9-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049330 Metallo-dependent phosphatases 10-299 3.6e-87 285.3 In-house 16-298 (309) alignment
Range on Protein: 10-299
Range on HMM: 16-298/309.0
LAKRMIEHLLKWGVtdaFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKI
| ...||.|||...   .. ......|.|| . ||  | .|.....|...||||||||.|.| ....|.||  ...||||.||||  | || |||...|.
lldllielllklkl...lseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkl

RYPHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCdeGLQVDLMWADPt
.||. |.|||||||.. .|.||||..|. || | ..|........ |||.|..|..|||.|||.| . ........|..| ..     || .||.|.|| 
lypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipld..gllcdllwsdp.

QDKCNTFAMNKqRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRP
.. ...||.|. | ..||||   ...||||.||.||.|.|.. ..|. ..|..|..|||||| |||.  |.||..........||....|
lpiregfapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfep

subfamily_PPP5C_pd Subfamily PPP5C 10-295 4.8e-69 225.8 In-house 16-304 (322) alignment
Range on Protein: 10-295
Range on HMM: 16-304/322.0
LAKRMIEHLLKWGV-TDAFTDKQIYTILEKAESTLKPLPAMLQVEHP----ITIVGDIHGQLDALIRYFDAVGYPP-KVQFLFLGDYVDRGAKSFEVSLL
..| ....||..    ...  | ...|| .|.. || ||........    .|. ||||||   |.  |.  |.|  .  .|| ||.||||. |.|| |.
itkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsvevilt

LFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGI-SQNCNSWESFKALKKPNTPltCDEGLQVD
|...|. ||. ..| |||||  .||.|||| .| . |   ..   ...||| |||.  . ...| .|||. |..  . . .. ... . |   .||| |.
llgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqp..peegllve

LMWADPTQDKCNtfaMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHV-SDSYELSFT
|.|.|| . .     .. .| ..| ||    . |||. .|.||.|.||| .||...  . |..|||||| || . .| ||.... .|  .| |.
llwsdpqeanGr...spskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfk

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 12-301 1.5e-187 614.5 In-house 1-290 (290) alignment
Range on Protein: 12-301
Range on HMM: 1-290/290.0
KRMIEHLLKWGVTDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRY
|||||||||.||.|||.||.|..||||.|..|.||||.|.||.||.||||||||||||.||||||||||||.||||||||||||||.|||||||||||||
krmiehllkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiry

PHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCDEGLQVDLMWADPTQD
.. |||||||||..|.||||||.|||.||||.|.|.|||.||.||.||||||..||||||||||...||||.||||||..||||||||||||.|||||.|
skkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd

KCNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPRM
|..|.|.|||||||||||.|||||.||||.||||||||||..|||||||.||.|||||||||.|||||.|||..||.|.|||..||.||.
kddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkprk

0045823 Metallo-dependent phosphatases 12-300 2.9e-92 302.7 In-house 31-324 (473) alignment
Range on Protein: 12-300
Range on HMM: 31-324/473.0
KRMIEHLLKWGvtdAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRY
...||||.|.|    .. .... .|..| . ||  | .|... .|...||||||||.|.| .. .|.||. ...||||.||||  | || .||...||.|
dlliehlkkeg...llpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkiky

PHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcdEGLQVDLMWADPtQD
|. |.|||||||.. .| ||||..|. .| | ........... |||.|..|..||..|||.| . ....  .....|.....  .|| .||.|.|| ..
pgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipd..dgllldllwsdP.we

KCNT------FAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKK------CVTVFSAPYYCGNDTNCGAIMHVSDSYeLSFTVLRP
.. .      | .| .| ....||......|||| || ||||.|.. .||...||..|      ..|||||| |||.  |..|......   .||....|
ddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdp

R
 
s

0053225 Metallo-dependent phosphatases 12-300 1.6e-80 263.6 In-house 10-291 (293) alignment
Range on Protein: 12-300
Range on HMM: 10-291/293.0
KRMIEHLLKWGVtdaFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRY
...||.||.. .   .. ......|..| . ||  | .|... .|...|||||.||.|.. .. .|.||  ...||||.||||  | || .||...|..|
dllielllllkl...lseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PHLVHLLRGNHECMKMNRLYGFYEELTRKR-GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMWADPTq
|. |.|||||||.| .| ||||..|  ||  . ..|........ |||.|..|..||..|||.| . ..... . ...|  .   .|||  ||.| ||. 
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplrip..legllldllwsdpd.

dKCNTFAMNKQRAIsVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
   ....... ... ||||   ...|||| || ||.|.|.| ..|. ..|..|.||||||| |.|  .|.||........  .|....|.
.lwsgwlpsyrglg.vvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv

subfamily_PPP3C_pd Subfamily PPP3C 13-287 1.3e-66 218.3 In-house 30-310 (452) alignment
Range on Protein: 13-287
Range on HMM: 30-310/452.0
RMIEHLLKWGVtdaFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYP
 . ||.|| |    ......  |.|.| . ||  ...|.|| |||..||||||   |.. |.  | | . ..||||||||||. |.|. | |.. || ||
vlkehflkegr...leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiayp

HLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLMWADPTQDK
. ..|||||||| ..   . | ||.. | . ... .. . |. ||| | . |. ||.|||.| . .| .. | |.. . |     |.  ||.|.||..| 
stlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkep..pasGplcdllWsdPledy

-----CNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFN------KKCVTVFSAPYYCGNDTNCGAIMHVS
      ..|  |. |  |.... |   .||.|  |  |.||||. ..|..   .         .|.|||| |..  .| .|.... 
geekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkye

subfamily_PPP4C_pd Subfamily PPP4C 14-297 2.6e-69 226.6 In-house 6-282 (288) alignment
Range on Protein: 14-297
Range on HMM: 6-282/288.0
MIEHLLKwgvTDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPH
.||.| .   ..  ..... .. .||.  |     . .|. |.|. ||||||.  |.. |.  |  |. ..|||||.||||  | |  ||| ..|.||| 
qieklrr...celikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypd

LVHLLRGNHECMKMNRLYGFYEELTRKRGG-RMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQDK
 ..|.|||||. .. . ||||.|  || |  ..||   .||. |.|.| . ..|.|.|||.| . .. .  ... . .     .||  .||.|.|| . .
ritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqe..vphegplcdllwsdpedae

cnTFAMNkQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVL
  ..|.   |    .||..  ..| .. ...||.|||.. .||... ||.| .||.||| ||    |  ||... .. .  |...
..gwavs.prgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 15-301 9.8e-102 333.0 In-house 12-295 (298) alignment
Range on Protein: 15-301
Range on HMM: 12-295/298.0
IEHLLKWGVTDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHL
.  | .  .| . ..... ...|.|.. .|  .....|. ||.. ||||||   |.| ||  |.||.. .|||||||||| ...|| .||..||..||. 
svslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnn

VHLLRGNHECMKMNRLYGFYEELTRKR-GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLMWADPTQDKc
. |||||||| ..|| |||||| .|.    |.. ..|.||| |||.| .|.||||||||.|.. .|......||.|  .   .| |..||.||||.. . 
ffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfds..keeslaidllwadpenav.

NTFaMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPRM
. . ....| .|||||.. . |.|.|| . |.|||| | |.|..|. .|| ||.||||.|||. .|. |.|.|..  ..||.||.|..
kgw.aensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 18-300 2.3e-168 551.3 In-house 1-282 (287) alignment
Range on Protein: 18-300
Range on HMM: 1-282/287.0
LLKWGVTDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHL
|||.||.|||.||.|...|||.|..|.||||.|.||.|||||||||||||.|.|.|.|||..||||.|||||||||||||.|||||||..||.||. |||
llkygvldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhl

LRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCDEGLQVDLMWADPTQDkCNTFA
||||||..|.|.||||.|||.|||..|...|...||.||||||||..||||||||||....|..|.||||||.|||.|||||||||.||||..| ..||.
lrGnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfe

MNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
.||.||||||||.|..||.||||...|||||||||.||..|||.|..|||||||||.|.|||.||...||.|.||||.||.| 
lnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 23-300 1.3e-86 283.5 In-house 20-294 (299) alignment
Range on Protein: 23-300
Range on HMM: 20-294/299.0
VTDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNH
.| .  .... |. . | |..   ...|.|| || ..||||||   |.| ||  |.||.|.||||||||||| . .|.  ||.|.||.||.  ..|||||
ltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnh

ECMKMNRLYGFYEELTRK-RGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMWADPTQDKCNtFAMNkQ
||  .||.||||||  .. .  |.|  .|. |. .||.  .| ||||||||.| . .. . .. | .|. |   .  |..||.|||| |   . .  |  
ecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdpp..npslgidllwadpdqsvkd.wlan.v

RAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
| .| ||||. . | ...|.. |. |||.| |.|..|. .|| ||.||||.|||.  |  |||.| .    .|.||.| 
rgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 24-300 7.1e-76 248.3 In-house 20-295 (297) alignment
Range on Protein: 24-300
Range on HMM: 20-295/297.0
TDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHE
..  |....  .|. | . .|   .|..|. || ..||||||.  |.| |   |.||  ..||||||||||  | |  .||..||...|  . |||||||
skviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhe

CMKMNRLYGFYEELT-RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCDEGLQVDLMWADPTQDKCnTFaMNKQR
|  .|. ||||||   | .  ||.  .|.||| |||.  . ..|||||||.|       ....|.| . .    |.|  ||.||||       | |..||
cefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegkerlvadllwadpisgls.gf.menqr

AISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
   . ||.  . .   .. | |..|||.| |.|..|.  .| ||.||||.|||.  || |.| . .  . || .||| 
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt

subfamily_PPP2C_pd Subfamily PPP2C 24-298 7.6e-67 218.5 In-house 14-284 (290) alignment
Range on Protein: 24-298
Range on HMM: 14-284/290.0
TDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHE
.. ...... .. |||.  |.    . .|. |.|..||.|||.  |.  |   |  |. ..||||||||||  | |   || . |.||.. . .||||||
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhe

CMKMNRLYGFYEELTRKRGG-RMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTqDKcNTFAMNkQR
  .. ..||||.|  || |   .|. . ..|. |||.| | ..|.|.|||.| . .. .  .||.. .     .||  .||.|.||  |. . ...  .|
srqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqe..vphegplcdllwsdpd.dr.ggwgis.pr

AISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLR
     ||..  ..| |. ||.||.|||..  ||.|...... ||.|||| ||    | .||. . |... ||    
gagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfd

subfamily_PPP7C_pd Subfamily PPP7C 24-177 6.6e-36 116.8 In-house 30-191 (383) alignment
Range on Protein: 24-177
Range on HMM: 30-191/383.0
TDAFTDKQIYTILEKAESTLKPLPAMLQVE----HPITIVGDIHGQLDALIRYFDAVGYPP-KVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLL
   .  | . .|| .|. .|| || . .|.    . .|. ||.||.|| |.  .   |.|  .  ..| ||.|||| .| |. |.|... . ||. |.| 
kkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevyln

RGNHECMKMNRLYGFYEELTRKR---GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNC
||||| . .|  |||  |.. |    | .. |. ..||  |||.. . ..|| .|||||.. 
rGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdkt

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 25-299 1.1e-78 257.5 In-house 6-282 (284) alignment
Range on Protein: 25-299
Range on HMM: 6-282/284.0
DAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYP------PKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLL
. ...|... .  .|  ..   .  |..| |..|||||||| . |.  .|  |.|       . ..||||||||||  | || .|||.||...|. | ||
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQdKCNTFAm
|||||   .|. ||||.|  ..   ...  .|  || .|||| |...|.|||||||..  . . ...|..|    . | |.  || |||| . . .... 
rgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpid..ipdigviadltwadpea.evegyk.

NKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRP
. .|    |||.| ...||||  | |.||||.| ..|..|. ..| ||.||||.|||.  | .|...|..  . |||||.|
esprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 25-300 4e-68 222.9 In-house 4-275 (280) alignment
Range on Protein: 25-300
Range on HMM: 4-275/280.0
DAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHEC
. .| ..| .|.   |. .     . . | || ..|||| | . . | || .|  |. ...||||||||| .  || .|||| ||||   ..||||||| 
nvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhet

MKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMWADPTQDKCNTFamNKQRAI
  .|..|||| |   | |  .| ..|..|| .|... . .|.||||||.| .    .. . . .|  ||  | || .||.|.|||.     |     |.|
psvnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepl..drgllidllwsdptnkgegwf..hsirgi

SVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
| .||.  ...  | | . ||.|||.| |.|....  .. .|||| | || . ||. |.. .    ..||  | | 
symfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 25-79 1.7e-09 30.3 In-house 7-61 (317) alignment
Range on Protein: 25-79
Range on HMM: 7-61/317.0
DAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYP
| |..|... .  .|  ..   | .|..| |.||||||||| . |.  .|  |.|
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 26-299 3.6e-65 213.1 In-house 5-299 (302) alignment
Range on Protein: 26-299
Range on HMM: 5-299/302.0
AFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDA------------VGYPpKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPH
 .. .......|. ...||   .. ..  |.||||||||| . |.| . |            ...  . .|.||||||||| || |   |.|..|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlypt

LVHLLRGNHECMKMNRLYGFYEELTR----KRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcDEGLQVDLMWADPT
   |||||||.  .|  ||| |||      | | ..|.....||  .|| | ||..|||.|||||.. .|.|. | .|.| . .| .. |  ||..|||.
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevt.edslaqdllfadpl

Q-------DKCNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRP
.        .   .| |  |..|||| .  . |. |.|.|.|||||| .  |||.|  .|| .|.|||| |  .  | ||...|    .|| .|||.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 26-299 6.8e-65 212.2 In-house 6-300 (302) alignment
Range on Protein: 26-299
Range on HMM: 6-300/302.0
AFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDA------------VGYPpKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPH
 .. .......|. ...||   .. ..  |.||||||||| . |.| . |            ...  . .|.||||||||| || |   |.|..|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlypt

LVHLLRGNHECMKMNRLYGFYEELTR----KRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcDEGLQVDLMWADPT
   |||||||.  .|  ||| |||      | | ..|.....||  .|| | ||..|||.|||||.. .|.|. | .|.| . .| .. |  ||..|||.
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevt.edslaqdllfadpl

Q-------DKCNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRP
.        .   .| |  |..|||| .  . |. |.|.|.|||||| .  |||.|  .|| .|.|||| |  .  | ||...|    .|| .|||.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 26-81 4.6e-07 22.2 In-house 10-65 (339) alignment
Range on Protein: 26-81
Range on HMM: 10-65/339.0
AFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPK
 |   ..  .  .|   .   | .|..| || ..||||||.| |.  .|  |.|  
lfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls

subfamily_PPP1C_pd Subfamily PPP1C 27-300 2.1e-97 318.7 In-house 10-279 (282) alignment
Range on Protein: 27-300
Range on HMM: 10-279/282.0
FTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMK
.. ..| ..|.||.. |.  |..|..|.|..||||||||.  |.|.|.. |.||. ..|||||||||| .| |. .||..|||.||. ..|||||||...
lkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesas

MNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQDkCNTFAMNKqRAISV
.||.||||.|  |. . ..|.....||| |||.| | ..|||.|||.|.. .| |  . ...| .    ..|| .||.|.|| ..  .... |. | .|.
inriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPle..vpekgllcdllWsdpdke.vlgwsend.rGvsf

VFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
.||.. ...||.|  |.||||||.| ..|..|  ... ||||||| |||.  |.||...|...  .||..|.|.
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 27-301 2.1e-89 292.3 In-house 6-276 (280) alignment
Range on Protein: 27-301
Range on HMM: 6-276/280.0
FTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMK
  . .|....|| .  |.   .|..|. |....||.|||   |.| |. |..||  ..|||||||||| . .|| |||..||.|||    .||||||...
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

MNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLMWADPTQdKCNTFAMNkQRAISV
.|| |||..|  |.    .. ..|.....|||.| |. ||||||||.||.  |.. .. |..|  .   || |. ||.|||| . |   .| | .| .||
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfds..edeclamdllwadpen.kvtgwaen.srgvsv

VFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPRM
.||.. . |. .|| . ||.| |.| |.|..|. .|| ||||||| |.|. .|  |.. |..  ..|| ||.| .
ifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpal

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 27-300 6.2e-77 251.6 In-house 8-277 (281) alignment
Range on Protein: 27-300
Range on HMM: 8-277/281.0
FTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMK
.|...| ... ..|. .    |. ....||..|||.|.| . |.| |. .| .|. ...||||||||| .|.|| .|||..||||.. . |||||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

MNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMWADPTQDKCNTFAmnKQRAISV
.|. ||||.|   | |  .| ..|. ||.||. | . .|.||||||.| .  . .  .   ||  .|  | || .||.||||...  . .|    | .| 
vnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnl..drGlviDllwadpdnkveewka..ssrGssf

VFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
.||.. .||  |.|.. ||.||| | |.|.. |  .| .||||.| ||   .|..|.. | .. ..|.  | | 
tfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-298 2.8e-59 193.8 In-house 20-290 (307) alignment
Range on Protein: 27-298
Range on HMM: 20-290/307.0
FTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMK
.| ...  .. .|.. .    |..... |  .|||.|||.. ||  |  .| ||.  ..| |||||||  |.|. ||||.||| ||. . |||||||  .
ytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiar

MNRLYGFYEELT---RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQDKCNTFAmnKQRA
.|. ||||||      | |  .|  .| .||.||. | .  .|||||||.|      . ..   ||        |.  |..||||     .  |    | 
vnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpir..npfrgivndmlwadpdpsvfewka..ssrg

ISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLR
  . || . .||  |.||. ||.|||..  .|.  |  .| .|.|||| ||    |.|....| ..  .    . 
sgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafv

PP2Ac_SM00156 28-300 6.7e-99 323.3 In-house 2-270 (271) alignment
Range on Protein: 28-300
Range on HMM: 2-270/271.0
TDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKM
........||.... ||  .....|..|.|.||||||||| |.| ..  |.||. ...||||||||| .| || ||||..||.||  |.|||||||. ..
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKpnTPLTCDEGLQVDLMWADPtQDKCNTFAMNKqRAISVV
|..|||.||. || | ...   ...|. |||.| |...|||||||.|.. .|..... ||.     ...|||..||.|.|| ..| ..|...| | .|||
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr..vkekpeegllidllwsdp.eqkekgfqpsk.rglsvv

FGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
||.. ...||||. |.||.|||||..||..| ..||.||.||||.||.. .| .|...|... .||. .|.. 
FgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq

PPP_3 28-296 8.3e-89 290.2 In-house 3-268 (271) alignment
Range on Protein: 28-296
Range on HMM: 3-268/271.0
TDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKM
. ........|... |.  . ......|.|..|||||||| |.. |. .| .|. ..||||||||||.||.|| |||...||.||. |||||||||. ..
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

NRLYGFYEELT-RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLMWADPTQDKcnTFAMNKQRAISV
|..|||..|.. .| | ..... |.||. |||.| . ...|..|||.|....|... | |.....   ..||. .||.. ......  ..  |..| ...
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkiev..peegklldlllssdpeke..eglenskrGagl

VFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTV
.||..  ..||.|  |.||.||||. .||...|...|.||||||| ||.. .| |||...... . .|..
lFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkq

subfamily_PPZ_pd Subfamily PPZ 28-299 1.2e-77 254.4 In-house 26-293 (300) alignment
Range on Protein: 28-299
Range on HMM: 26-293/300.0
TDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKM
 ...|  |  ||   .   ||.|..  .. ||||.|||   |.| |  .|.||. ..|||||||||| .|.|  |||.||||.||  . |||||||| ..
knseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanv

NRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTqDKCNTFAMNkQRAISVV
 |.||||.|  |.   ..|. . . || |||.| |  .|.|.|||.|   || .  . . .|      | ||  ||.|.||| |  | .  | .| .| .
trvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptd..vpdfglindllwsdpt.dssnewedn.ergvsyc

FGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRP
. .  .. ||.|.|. |..||| | ..|..|. ..  ||||||| |||.  | ||.| ||.    || .| |
ynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp

PPP_1 29-286 7.2e-81 264.3 In-house 3-264 (264) alignment
Range on Protein: 29-286
Range on HMM: 3-264/264.0
DKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMN
 ........|... |.  . .|.|...||..||||||.| |.. | . | .|. ..|||||||||| .|.|. |||...|..||. ..|||||||. ...
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

RLYGFYEELT-RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALK----KPNTPLTCDE-GLQVDLMWADPTQDKcnTFAMNKQR
. |||..|.  .| . .... ...||. |||.| . ..||..|||.|.. .. .. . ..     |..  .||.   .|| .. |.....  ..  | .|
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqe..eavansiR

AISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHV
 .. .||..  ..||.| .|.||.||||| .||..||...|.||.|||. |. . .| ||....
GagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 30-301 7.7e-80 261.3 In-house 6-275 (284) alignment
Range on Protein: 30-301
Range on HMM: 6-275/284.0
KQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNR
... |.| .| | ..  | ...|. || |.||||||.  |.| ||  |.| . ..|||||||||| . .|  ||||.||. .|  . .|||||||  .|.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

LYGFYEELTRKR-GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcDEGLQVDLMWADPTQDKcNTFAMNkQRAISVVF
 ||||||  |.     ..  .. || ..|| | |||||||||||.|.  .    ..|.|.|       . | .|..|.|||. . . .  |  | .| ||
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpe.pntlaidilwsdptnfq.kgwnpn.srgvsyvf

GQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPRM
|   |  .| .| . |.||||.| |.|..|. |.. ||.||||.|||.  |. |.|.|      || ||||| 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprk

subfamily_PPG1_pd Subfamily PPG1 30-297 1e-58 192.0 In-house 17-293 (300) alignment
Range on Protein: 30-297
Range on HMM: 17-293/300.0
KQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNR
  .  . .|    |     . ... |.|.|||.|||.  ..  |.  |  |  ..||||||||||  | |   || . |.|||  ..|||||||  .. .
vtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitq

LYGFYEELTRKRGG--RMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPT---------QDKCNTFAM
 |||| |  || ||  |.|. . ..|. | |.| . . | |.|||.| .. | .  | | . .     .||   ||.|.||           |.   . .
vygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfre..vpnegaladllwsdpeennnptldhpdregqhfv

NKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVL
. ||     .|..    ||..  .  |.|||.. .||.. ||..|  ||.||| ||    |  .|. . .  |  | | 
vsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy

subfamily_PPP6C_pd Subfamily PPP6C 31-294 1.7e-62 204.2 In-house 19-278 (290) alignment
Range on Protein: 31-294
Range on HMM: 19-278/290.0
QIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRL
..  . ..    |    ..  |. |.|..||||||.  |   | . |  |. ...||||.||||  |.|   .|.. |..||. . |||||||. .. ..
dlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqv

YGFYEELTRKRG-GRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPtqDKCNTFAMNkQRAISVVFG
||||.| ..| | .  |. . .||. |...| . ...||.|||.| . .  .. . ... .      .|  .||.|.||  .. .|.|.  .|    .||
ygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqe..iphkgafcdlvwsdp..edvetwavs.prgagylfg

QKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSF
.|  ..|..   |.||.|||.. .||... |..| |||.||| ||    |  .|....|. | ..
skvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeerea

subfamily_PPPLV_pd Subfamily PPPLV 35-288 2.2e-48 158.0 In-house 5-277 (290) alignment
Range on Protein: 35-288
Range on HMM: 5-277/290.0
ILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIrYFDAVGYPP-----KVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNR
. ..|   |     .|... |. ..||.||.   || ||. | .         ..||||||||||  |.|.   |.  |. ||  |.|||||||   .  
lcdvavdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

LYGFYEELTRKRGGR---MWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCD---EGLQVDLMWADPTQDK----------C
 . .. | . | | .   .|  ..|||. ||| | . ....|.|.|| .   .     |...    |  |     | .|..|.|| .|.           
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

NTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNdTNCGAIMHVSD
. |. |..|  . ||... |. |||. .|| ..||||| ..|...  . . .||||.  |||  .|  |.. |. 
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdk

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 48-300 2e-69 227.2 In-house 1-256 (263) alignment
Range on Protein: 48-300
Range on HMM: 1-256/263.0
AMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRKRG-----
|.|... || |.|| ||| . |.| |.|.|   | |.|||||||||| .|.|| .|||  |.  |. .||||||||   .|. |||. || ..       
allelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevy

GRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPlTCDEGLQVDLMWADPTQDkCNTFAMNKQRAISVVFGQKGLDDFLKKLGL
  .. ....||. .|||| | .||||||||||   .| .  .|.  |    .    | .||.|||| .| .. |  || |||| |||.| .||. |.| .
esvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplplet.akthplacdllwadpekd.akgfepnkiraisnvfgkkevddlckrldi

SLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
 ||||||.| . |. |. ... .|||||  |  .  |  |.. |    ||||  |.| 
dlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpe

Metallophos Calcineurin-like phosphoesterase 54-251 2.9e-41 134.9 Pfam-A 1-198 (200) alignment
Range on Protein: 54-251
Range on HMM: 1-198/200.0
HPITIVGDIHGQLDAL----IRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLL--FCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELT---------
..|...||.||.|| |     ..... ....   .|||||.||||  | |.  ||  ...|...|. |.|||||||.. .|  |||..|           
lrilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang

-------------------------RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFkalkkpntpltcdeglqvdlmwadptqdkc
                          ..|.. ... ...|..|||.| |...||..||..|   .|..                                
eeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi..............................

ntfamnkqraISVVFGQKGLDDFLKKLGLSLIVRAHEV
           |. || . |...|.| |. |..|.|. 
..........gselfgpdalekllekygvdlvlrGHtH

subfamily_YNL217W_pd Subfamily YNL217W 55-141 1.4e-08 27.5 In-house 11-88 (235) alignment
Range on Protein: 55-141
Range on HMM: 11-88/235.0
PITIVGDIHGQLDALIRYFD--AVGYPPKVQFLFLGDYVDRGAKSFEVSLLLfcykirYPHLVHLLRGNHECMKMNRLygfyeELTRKR
 . .|||.||  | ||. .|  ..|  . |  ...|| ...| || ||  ..        . |. ..|||| . . ..     .. .| 
rllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkp

PPP_2 56-251 5.8e-63 205.2 In-house 1-197 (198) alignment
Range on Protein: 56-251
Range on HMM: 1-197/198.0
ITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELT-RKRGGRMWRQYQNVFN
.|..||.||||| |.. |.  . .|. ..||||||||||.||.|| |||...|..||. |||||||||. |.|..|||..|.. .| | ..... |.||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

ELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLM----WADPTQDKcnTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHE
 |||.| . ...|..|||.|........ |  .....   ..||. .||.    . ||....  ..  |..| ....||..  ...|.|  |.||.||||
lLplaalidekvlvvHGGlseeiklldqikkeerkies..peegklldlleeeklsdpkeke..ellansarGagllfgpdvteelleknklkliiRaHe

V
|
v

PPP_4 56-251 1.8e-62 203.9 In-house 1-196 (197) alignment
Range on Protein: 56-251
Range on HMM: 1-196/197.0
ITIVGDIHGQLDALIRYFDAV-GYPP-KVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVF
.|.||||||||| |. ..  . | |. . ...|||||||||..|.|| |||...|..||. |.|||||||....|.||||..|...|.| ..... |.||
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NELPLCARVGQRILCMHGGISQNCNSWESFKALKKPnTPLTCDEGLQVDL-MWADPTqDKCNTfAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEV
. |||.| . ...|..|||.|....|... ...... .. ...|..  || .|.||. .. ..   |..| ....||..  ..||.| .|.||.|.||.
dllplaalidekvlvvhgglsdelesldkierierk.iespleeekrkdlllwsdpr.eaqeg.lansvrGagllFgpdvtekfleknnlkliirshel

PPP_5_Dcr2 56-251 5.2e-60 195.8 In-house 1-198 (199) alignment
Range on Protein: 56-251
Range on HMM: 1-198/199.0
ITIVGDIHGQLDAL-IRYFDAVGYPP-KVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRK-RGGRMWRQYQNV
.|..||.||||| | .. |. .| |. . ...|||||||||..|.|| |||...|..||. |||||||||....|..|||..|  .|  | ....  ..|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPnTPLTCDEGLQVDL-MWADPTqDKCNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEV
|..|||.| . ...|..|||.|....|.|. ...... .... ..| . || .|.||. |....   |..| ....||..  ..||.| .|.||.|.||.
fdwlPlaalidekvlvvhgglspeiksiellekierk.ieipeekgekadlllwsdpr.daqegcklnseRGagllfgpdvtekfleknnlkliirshel





Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 56-175 6.7e-06 18.2 Pfam-A 3-93 (156) alignment
Range on Protein: 56-175
Range on HMM: 3-93/156.0
ITIVGDIHGQLDALIRYFDAVgyPPKVQFLFLGDYVDRgaksFEVSLLLfcYKIRyphlVHLLRGNHEcmkmnrlygfY----------Eeltrkrggrm
| |..|.||.|||| .  ...        |..||.|..    .||  ||   .|.    |. .||||.          .                     
iaiiSDlHgnldaleavledi..kevdlilhaGDlvep....eevvell..edip....vlavrGnhD..........eaelpkelavel..........

wrqyqnvFN-------ElplcarvGQRILCMHGGISQ
       ..       |       |.|.| .||   .
.......llaaaaleie.......gdrvllvhgtpls

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 83-300 1.1e-72 237.9 In-house 102-315 (317) alignment
Range on Protein: 83-300
Range on HMM: 102-315/317.0
QFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWES
..||||||||||  |.|| .|||..|..||. |.|||||||   .|. ||||.| ...   ...  .|..|| ||||| |...|||||||||..  . . 
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlkq

FKALKKPNTplTCDEGLQVDLMWADPTQDkCNTFAmNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGA
...||.|    . | |.  || |||| ..  .... . .|  . |||.| ...||||| | |.||||.| ..|..|. ..| ||.|||| |||.  | .|
ldklkrpld..ipdvGvladltwadpdae.vkgyk.esarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaa

IMHVSDSYELSFTVLRPR
...| .  ..|..|||| 
vlsvdkklkisinvlrpe

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 83-300 4.2e-58 190.1 In-house 121-334 (339) alignment
Range on Protein: 83-300
Range on HMM: 121-334/339.0
QFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWES
..||||||||||  |.|| .|| . |. ||  ..|||||||   .|  |||| |.  .   ...  .||.|| .|.|| . . |.|||||||.   |.. 
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

FKALKKPNTplTCDEGLQVDLMWADPtqDKCNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGA
|  .|.|      | |.  || ||||  |  .       |  |.|||   |  ||||| | ...| |.| ..|..|.  .. ||.|||| |||.. |  |
fsvfkrple..ipdvgvltdltwadp..dptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaa

IMHVSDSYELSFTVLRPR
.. .    ..|  |.|| 
vfsidkklkisinvfrpe

subfamily_PPP7C_pd Subfamily PPP7C 199-289 2.9e-18 58.7 In-house 235-324 (383) alignment
Range on Protein: 199-289
Range on HMM: 235-324/383.0
LQ-VDLMWADPTQDKCNtfAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDS
 | .|..|.|| ...      |  |   . ||    ...|.| .|.|..|.||  .||..|  .||..|.|||  |  . .| || ......
rqvldilwsdpkakeGc..kpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkd