Gene T25B9.2 in Caenorhabditis elegans

Synonym: CELE_T25B9.2, T25B9.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP188_AA protein Get Run
CeleP188_AA_3-331 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 1-332 8.2e-247 810.5 In-house 8-339 (339) alignment 
Range on Protein: 1-332
Range on HMM: 8-339/339.0
MDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQEFEALKDITVRSRETGKRPQSEPHSTQPESSNDVKPPVAA
.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ldlfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwplssqefealkditvrsretgkrpqsephstqpessndvkppvaa

PKSVNKEVTTGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCM
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
pksvnkevttgykrylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcm

HGGISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNY
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
hggisehltsfnqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapny

CGQNDNTAAVFSIDKKLKISINVFRPESRDKK
||||||||||||||||||||||||||||||||
cgqndntaavfsidkklkisinvfrpesrdkk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 1-329 1.2e-182 599.1 In-house 6-317 (317) alignment 
Range on Protein: 1-329
Range on HMM: 6-317/317.0
MDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQEfealkditvrsretgkrPQSEPHSTQPESSNDVKPPVAA
.|||...||.|||.|||||.|.||..|.||||....|||||||.||||.||.|||||||||                 ..|||.|...|||.|||..|||
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwplssqe.................eksepkslllesskdvkqtvaa

PKSVNKEVTTGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCM
.||||||||.|||.||||||||||||||.||||||.||||.|||...|||||||||.|||.|||||||..||.|.|||.||..|||.|.|||.|..|.||
vksvnkevtkgykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcm

HGGISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNY
||||||.|....|....||||.|||||||.||||||||...||||.|||||..|||..|...|||||||..|.|.|||||||||||..|.||||||||.|
hGGiseelldlkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsy

CGQNDNTAAVFSIDKKLKISINVFRPESR
|||.||.|||.|.||||||||||.|||||
cGqldniaavlsvdkklkisinvlrpesr
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 2-327 5.2e-121 396.5 In-house 6-283 (284) alignment 
Range on Protein: 2-327
Range on HMM: 6-283/284.0
DLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQEFEAlkditvrsretgkrpqsephstqpessndvkppvaap
.|.   || |||.|||||.| |.. |..|||. ..|||||||.||||.||.|||| ...| .                                      
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeake.....................................

ksvnkevttgyKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMH
           |.||||||||||||||.||. || |.|| .||...||||||||| ||  |||| | . ||  .|||.||  ||..|.|||... |.|||
...........kkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmh

GGISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYC
|||||.| ...|.  ..||..|||.||..|||||||. . .||| | |||  |||. |.. |||| .|..|.| |||| ||||||  |.|||||||| ||
ggisedlldlkqldklerpidipdigviadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsyc

GQNDNTAAVFSIDKKLKISINVFRPE
|| || |||...|..| .|..|..|.
gqldniaavlnvdeelvasftvlkpd
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 2-60 6.1e-10 31.5 In-house 8-66 (287) alignment 
Range on Protein: 2-60
Range on HMM: 8-66/287.0
DLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQ
| |   .. |. ....|..   | .|..|||| ..||||||.|||| ...  | .   |
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvq
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 2-60 1.5e-09 30.3 In-house 14-72 (290) alignment 
Range on Protein: 2-60
Range on HMM: 14-72/290.0
DLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQ
| |   .. |. ....|..   | .|..|||| ..||||||.|.|| ..|  | |   .
dafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvk
0045823 Metallo-dependent phosphatases 4-331 2.8e-100 329.1 In-house 43-328 (473) alignment 
Range on Protein: 4-331
Range on HMM: 43-328/473.0
FCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGwplssqefealkditvrsretgkrpqsephstqpesS---Ndvkppvaa
. . .| .|...|.|....|| .|.|...| | ||||||.||||..|...|                                        .        
lpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekig....................................fpped........

pksvnkevttgykRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCM
             |..||||.|||||.| ||. || |||..||....|||||||.| .|. |||..|. ..|...||| |.. ..  |..|||...| ..
.............rlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfv

HGGISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPdPTEKG--------YKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRR--
|||.| .|.. .|    .||||||| |.|.|| |.||  ...|        . .| |||...|||.|.. |||| .|....|||..|..|||.. ...  
HGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvi

----LVTIFSAPNYCGQNDNTAAVFSIDKKLkISINVFRPESRDK
    ..|.||||||||...| |||  ||..| ||. .|.| . ..
giDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpl
0049330 Metallo-dependent phosphatases 5-329 1.4e-95 312.9 In-house 31-301 (309) alignment 
Range on Protein: 5-329
Range on HMM: 31-301/309.0
CAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPlssqefealkditvrsretgkrpqsephstqpessndvkppvaapksv
   || .|...|.|...|||..|.|...| | ||||||.||||..|...|.|                                                
seeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfp................................................

nkevttGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGI
      .  |..||||.|||||.| ||. || ||||.|||...|||||||.| .|  |||..|. ..|.|.|.| |..... .|..|||...|.|.|||.
......pedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGl

SEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQN
| .|.. .|.. ..||||||. |.|.||.|.||.|. .|. |. ||...|||. |.. ||||..|...||||..|..||..| ...|.|.||||||||..
spdlllldqirelerpleipldgllcdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrl

DNTAAVFSIDKKLKISINVFRPESR
.| .||  ||..|.||. .|.| ..
gnlgavleidedlvisfllfepvpl
0053225 Metallo-dependent phosphatases 5-326 1.3e-87 286.8 In-house 23-290 (293) alignment 
Range on Protein: 5-326
Range on HMM: 23-290/293.0
CAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPlssqefealkditvrsretgkrpqsephstqpessndvkppvaapksv
 . || .|.. |.|....||..|.|...| | |||||..|||||.|.. |.|                                                
seeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfp................................................

nkevttGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRY-DAQLYECFQNMFNVFPFCAVINNTIMCMHGG
      .. |..||||.|||||.|.||. || |||| |||...|||||||.. .|  |||..|. ..| .|.|.. ... .. .|..|.|...|...|||
......pedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgG

ISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDpTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQ
.| .|....|    .|||.||. |.|.|| | |||   .|. || ||...|||. |.. |||| .|...||||||| |||... ...|||.||||||.|.
lspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgr

NDNTAAVFSIDKKLKISINVFRP
..| .||  .|..|.... .|.|
lgnlgavlaldeglvwgfklfap
subfamily_PPP4C_pd Subfamily PPP4C 5-55 1.7e-10 33.6 In-house 17-67 (288) alignment 
Range on Protein: 5-55
Range on HMM: 17-67/288.0
CAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGW
.  |. .||..|||..  |    ....|. | ||||||| ||| .....| 
keeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggd
PP2Ac_SM00156 6-327 1.6e-106 348.3 In-house 3-270 (271) alignment 
Range on Protein: 6-327
Range on HMM: 3-270/271.0
AAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLdmngwplssqefealkditvrsretgkrpqsephstqpessndvkppvaapksvN
. |..||.....|.. .|. .....||..|.||||||.|||| .|                                                      .
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll......................................................e

KEVTTGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGIS
.  .. ...|.||||||||||.|.||..||.|||..||....||||||||.|||. |||..||...|....||.|...|...|..|.....|.|||||.|
lageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGls

EHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQND
..|.|..... .||. |.|. |.|.||.|.||. .|||..||.||.|.|||. |.. ||||..|...||.|.||..|||||  ..|||||||||||....
peleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefs

NTAAVFSIDKKLKISINVFRPE
|.|||....|.||.||......
nkaavlkveknlklsieqlkeq
subfamily_PPP1C_pd Subfamily PPP1C 6-59 1.9e-14 46.5 In-house 12-65 (282) alignment 
Range on Protein: 6-59
Range on HMM: 12-65/282.0
AAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSS
 ||. .|...|||.. |.||.|.||||. ..||||||. ||| .....| | .|
eaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpes
subfamily_PPG1_pd Subfamily PPG1 6-54 5.1e-08 25.5 In-house 16-64 (300) alignment 
Range on Protein: 6-54
Range on HMM: 16-64/300.0
AAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNG
 . . ||... .||. .|    ....|. |.||.|||| |.| .... |
evtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkigg
subfamily_PPP6C_pd Subfamily PPP6C 6-54 1.5e-07 23.9 In-house 17-65 (290) alignment 
Range on Protein: 6-54
Range on HMM: 17-65/290.0
AAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNG
 ..| .||..  .|.  |     ...|. | ||||||| ||. ..   |
endlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtgg
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 6-52 1.8e-07 23.7 In-house 8-54 (302) alignment 
Range on Protein: 6-52
Range on HMM: 8-54/302.0
AAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDM
  ||  |..   ||.  |  . .. .|. ..|||||||.||. .| .
ksellllieaviellkkektlaeispPvtivGdihGqfedlvrilna
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 6-52 1.9e-07 23.6 In-house 9-55 (302) alignment 
Range on Protein: 6-52
Range on HMM: 9-55/302.0
AAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDM
  ||  |..   ||.  |  . .. .|. ..|||||||.||. .| .
ksellllieaviellkkektlaeispPvtivGdihGqfedlvrilna
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 7-68 5.6e-12 38.3 In-house 27-87 (298) alignment 
Range on Protein: 7-68
Range on HMM: 27-87/298.0
AELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSsQEFEALKDI
... .|.. |.... . . .....||| | ||||||. ||| ..| .|.| . ...  | | 
edveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppd.anylflGdy
PPP_3 7-60 6.4e-12 38.0 In-house 5-57 (271) alignment 
Range on Protein: 7-60
Range on HMM: 5-57/271.0
AELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLlAMLDMNGWPLSSQ
 ||.||.....|.. .|.. ....||. |.||||||.|||   |  || | ...
nelkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspet
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 7-73 7.5e-12 38.1 In-house 27-92 (299) alignment 
Range on Protein: 7-73
Range on HMM: 27-92/299.0
AELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSqEFEALKDITVRSR
 || .||. |.. . |.. .|..|||| | ||||||. ||| ..|..|.|  . .|  | |   | |
qelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdv.nflflgdyvdrgr
subfamily_PPZ_pd Subfamily PPZ 7-68 5.8e-11 35.4 In-house 28-88 (300) alignment 
Range on Protein: 7-68
Range on HMM: 28-88/300.0
AELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQeFEALKDI
.|. ..|..||||. ..| .|.|  .. ..||.|||. ||| ..   |.| |.. .  | | 
seilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsan.ylflgdy
PPP_1 7-54 7e-11 34.9 In-house 4-51 (264) alignment 
Range on Protein: 7-54
Range on HMM: 4-51/264.0
AELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNG
.|||||.....||. .|.. |.....| | ||||||||||| .  . |
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvgg
subfamily_PPP2C_pd Subfamily PPP2C 7-54 1e-08 27.7 In-house 20-67 (290) alignment 
Range on Protein: 7-54
Range on HMM: 20-67/290.0
AELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNG
.|..|||..|.|.. .|    ....|. |.||.|||| ||| .. . |
sevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkigg
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 7-67 3.6e-07 22.6 In-house 9-68 (280) alignment 
Range on Protein: 7-67
Range on HMM: 9-68/280.0
AELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSsQEFEALKD
|.. .. .. ....  .  .....||. | ||.|||. ||| ...  ..|   |..  | |
adidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppd.qnylflgd
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 7-55 1.8e-06 20.4 In-house 11-59 (281) alignment 
Range on Protein: 7-55
Range on HMM: 11-59/281.0
AELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGW
 |. .. . .. .. .|  . ....|| |.||.|.||.|| ..... | 
eeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgr
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 8-56 3.1e-06 19.6 In-house 24-72 (307) alignment 
Range on Protein: 8-56
Range on HMM: 24-72/307.0
ELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWP
|. .. . |. .. ||  .. .. |  |.||.||||.||. |. . | |
efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrp
subfamily_PPP3C_pd Subfamily PPP3C 10-321 4.7e-73 239.5 In-house 47-316 (452) alignment 
Range on Protein: 10-321
Range on HMM: 47-316/452.0
AELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGwplssqefealkditvrsretgkrpqsephstqpessndvkppvaapksvnkevT
... ..| .|. .|. .|..|||| |.||||||| ||| .....|                                                       
lkiieeaakllkkektlleveaPitviGdihGqfydllklfevgG......................................................d

TGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLT
    .||||||||||| ||.|.|. | |||.|||....|||||||.| .   . | .|....|. ..|. . . |...|. |..|.  .|.|||.| ...
PastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeik

SFNQFSVFKRPLEIPDVGVLTDLTWADPDP------TEKGYKP-SARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDG------RRLVTIFS
|...   ..|  |.|  | | || |.||        ||. ..| |.|| |....  |   ||.| ||  .|| |.. ..||. .          |.|.||
slddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfs

APNYCGQNDNTAAVFSIDKKlKISI
||||..  .| |||. .... .. |
apnyldvynnkaavlkyenn.vmni
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 11-59 3.4e-09 29.5 In-house 10-58 (284) alignment 
Range on Protein: 11-59
Range on HMM: 10-58/284.0
ELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSS
 |  .| ...  .|.... ..|| . ||||||| ||| ..| ||.|  .
tllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphra
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 26-68 3e-08 26.3 In-house 45-86 (297) alignment 
Range on Protein: 26-68
Range on HMM: 45-86/297.0
FLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSqEFEALKDI
.....||| | ||||||| ||| ..   ||| .. ..  | | 
mvevnapikvcgdihgqfpdllrlfhrggwppta.nylflgdy
Metallophos Calcineurin-like phosphoesterase 32-278 1.5e-35 116.3 Pfam-A 2-198 (200) alignment 
Range on Protein: 32-278
Range on HMM: 2-198/200.0
PICVMGDIHGQFDDLLamldmngwplssqefealkditvrsretgkrpqsephstqpessndvkpPvAAPKSVNKEVTTGYKRYLFLGDYVDRGPFSMEV
.| |.||.||..|||                                                    .. .  .. .  .   .|||||.||||. | |.
rilvigDlHgglddle.................................................d.lllillkiaaeekpdlvlflGDlvdrgdwsset

VILL--TALKLAYPDRIYLLRGNHESRSVNTSYGFYREVN----------------------------------YRYDAQLYECFQNMFNVFPFCAVINN
  ||   .|||..|....||||||||...|. |||. |..                                  ....   .| ... |.  | .| ...
lalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdg

TIMCMHGGISEHLTSFNQFsvfkrpleipdvgvltdltwadpdptekgykpsargASFVFGPPALRAFLKKLDLQMVIRGHQV
.| ..||..|... | ..                                     .|. |||.||. .|.| ....|.|||. 
killtHgplsssggsgddi....................................gselfgpdalekllekygvdlvlrGHtH
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 34-315 1.3e-06 20.5 Pfam-A 4-155 (156) alignment 
Range on Protein: 34-315
Range on HMM: 4-155/156.0
CVMGDIHGQFDDLLamldmngwplssqefealkditvrsretgkrpqsephstqpessndvkppvaapkSVNKEVtTGYKRYLFLGDYVDrgpfSMEVVI
....|.||..|.|                                                         | ...  ... .|..||.|.    ..||| 
aiiSDlHgnldale.......................................................avledi.kevdlilhaGDlve....peevve

LLTALklaypdRIYLLRGNHESRSVNTSYGFYRevnyrydaqlyecfqnmF--------NvfpfcaviNNTIMCMHGGISEhltsfnqfsvfkrpleipd
|| ..      ... .||||.   ..... .                   .        .        ..... .||                       
lledi......pvlavrGnhDeaelpkelavel.................llaaaaleie........gdrvllvhgtpls...................

vgvltdltwadpdptekgykpsargasFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEfFDGRRLVTIFSAPNYCGQNDNTAAVFSIDK
                           . ... .|.. ||. . ..|. ||  .    .  .|...|.  |. .  .... | |.. ...
...........................vqsseeelaellkeagadlvflGHtHkpkvek.rggtlvvnpGsvgepregdeatyalldved
PPP_2 111-278 2.7e-57 186.7 In-house 25-197 (198) alignment 
Range on Protein: 111-278
Range on HMM: 25-197/198.0
GYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVN-YRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLT
  ..||||||||||| .|.||..||.|||| ||....||||||||..||. |||..||   ......|. .|..|...| .|.|.......|||.||...
perkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfelLplaalidekvlvvHGGlseeik

SFNQFSVFKRPLEIPDVGVLTDLT----WADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQV
...| .  .|. |.|. | |.||.    . ||. .|.....|||||...||| . . .|.| .|...|| |.|
lldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_PPP1C_pd Subfamily PPP1C 112-328 5.9e-92 300.8 In-house 64-280 (282) alignment 
Range on Protein: 112-328
Range on HMM: 64-280/282.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
 ..||||||||||| .|.|...|| |.|. ||....|||||||| |.|. |||| |.. ||...|...|...||..|..|.... |.|.|||.|..|.|.
esnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
.| .  .||||.|. |.|.|| |.||| . .|.. ..|| ||.||. ....||.| ||....|.|||||||||||  |.|||.||||||||. ||..||.
eqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavl

SIDKKLKISINVFRPES
|.|..|..| ....|..
svdeellvsfqilkpak
PPP_3 112-325 3.7e-79 258.5 In-house 56-270 (271) alignment 
Range on Protein: 112-325
Range on HMM: 56-270/271.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVN-YRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTS
 ..||||||||||| .|.||..|| |||. ||....|||||||||..|. |||..||   ......|. .|..|...| .|.|.......|||.|....|
etkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiks

FNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAV
..| .  .|. |.|. | |.||.. ... .|.|...|.|||...||| . . ||.| .|...|| |...|.|||..  ...||.|||||||....|..|.
ldqikklerkievpeegklldlllssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagai

FSIDKKLKISINVFR
......|. ......
lkleealtsefkqle
subfamily_PPP4C_pd Subfamily PPP4C 112-326 5.8e-67 218.9 In-house 70-284 (288) alignment 
Range on Protein: 112-326
Range on HMM: 70-284/288.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYD-AQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTS
 ..||||||.|||| .|.|  .|| |||. |||||.|.|||||||..  .|||| |.  .|  |....   ..|. ....|.|.. |.|.|||.| ....
etnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsist

FNQFSVFKRPLEIPDVGVLTDLTWADPDPTEkGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAV
...  .  |  |.|. |.|.|| |.||. .| |.  | ||| ..||  .   | .. |.....| ||.| .|| .   ....|..|||||| .  | ||.
ldeirsidrkqevphegplcdllwsdpedae.gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaai

FSIDKKLKISINVFRP
. .|..|.   ..|  
leldeeldkdfkifea
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 112-326 9.2e-59 192.1 In-house 71-299 (302) alignment 
Range on Protein: 112-326
Range on HMM: 71-299/302.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYD----AQLYECFQNMFNVFPFCAVINNTIMCMHGGISEH
 ....|||||||||. |.| . |. |||. || .  |||||||....| .|||  |.. |.      ...| |...|  .|. |.. . |.|.|||||..
sdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk

LTSFNQFSVFKRPL-EIPDVGVLTDLTWADPDPTE---------KGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSA
|.|... .  |||| |. .  . .|| .|||  ..         |  |   || |.||   |.| . |.|.|....|.||..  |. ||  ..|.|||||
lesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsa

PNYCGQNDNTAAVFSIDKKLKISINVFRP
|.|  . ||. ||. .| . |.|| |.|.
prymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 112-326 1.7e-58 191.2 In-house 72-300 (302) alignment 
Range on Protein: 112-326
Range on HMM: 72-300/302.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYD----AQLYECFQNMFNVFPFCAVINNTIMCMHGGISEH
 ....|||||||||. |.| . |. |||. || .  |||||||....| .|||  |.. |.      ...| |...|  .|. |.. . |.|.|||||..
sdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk

LTSFNQFSVFKRPL-EIPDVGVLTDLTWADPDPTE---------KGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSA
|.|... .  |||| |. .  . .|| .|||  ..         |  |   || |.||   |.| . |.|.|....|.||..  |. ||  ..|.|||||
lesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsa

PNYCGQNDNTAAVFSIDKKLKISINVFRP
|.|  . ||. ||. .| . |.|| |.|.
prymnesdnkGavlkvdtngklsisvlrn
PPP_4 112-278 2.2e-55 180.8 In-house 28-196 (197) alignment 
Range on Protein: 112-278
Range on HMM: 28-196/197.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
 ..|.|||||||||..|.||..||.|||| ||....||||||||.|.|  |||..||  .. ..... .|..|.. | .|.|.......|||.|..|.| 
ersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfdllplaalidekvlvvhgglsdelesl

NQFSVFKRPLEIP-DVGVLTDLT-WADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQV
..    .|. |.| . ... ||  |.|| ....|...|.|||...||| . . ||.| .|...||.|..
dkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 112-279 1.7e-52 171.3 In-house 28-199 (199) alignment 
Range on Protein: 112-279
Range on HMM: 28-199/199.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYR-YDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTS
 ..|.|||||||||..|.||..||.|||| ||....|||||||....|  |||. ||  . . ...|. ....|.. | .|.|.......|||.|... |
erlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvfdwlPlaalidekvlvvhgglspeiks

FNQFSVFKRPLEIP-DVGVLTDLT-WADPDPTEKG-YKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVV
 ..    .|. ||| . |.  ||. |.|| .. .|   .| |||...||| . . ||.| .|...||.|...
iellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 113-329 2.4e-90 295.6 In-house 79-296 (298) alignment 
Range on Protein: 113-329
Range on HMM: 79-296/298.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRY-DAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
. ||||||||||| ...||..|| | |. ||....|||||||  ..|  |||| |.. || . .||. ||..||..|..|.| . |.|||||.|..|.|.
anylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
.|.  .||| . ..  . .|| ||||. . ||.....||.|.|||  ... .|.|||. .|.|.|||| |||||| ...||||||||.|||| ||.||| 
dqlrelkrpfdskeeslaidllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavm

SIDKKLKISINVFRPESR
..|.||..| .|..||..
kvdeklvvsfevlkpekk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 113-330 4.3e-83 271.7 In-house 61-278 (280) alignment 
Range on Protein: 113-330
Range on HMM: 61-278/280.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
. ||||||||||| . .||..|| | |. ||.....||||||  |.|  |||. ||  ||. .||. ||.... .|..|...  |.|||||.|..| |..
qnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvsld

QFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFS
... ..||.. .|  . .|| ||||.    |.  ..||.| .||   .. . .|||.....||||||.|||||| ...|||.||||.|.|. ||.|||  
dlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavli

IDKKLKISINVFRPESRD
.|..|..|..|..|. |.
vderlivsfevlkpalre
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 113-329 1.5e-77 253.6 In-house 63-279 (281) alignment 
Range on Protein: 113-329
Range on HMM: 63-279/281.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
....|||||||||| |.||.||| .||..|.|||.|||||||  |||  |||| |  ..|  .|.  ||. || .|. | |.. ..|||||.|  ||. .
evlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltald

QFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFS
.     .|.. .| |.. || |||||.  ...| |.||.||.||   .    |.|.....||.|||| |||| . ||.|.|.||.|||| .  |.|||  
elrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlk

IDKKLKISINVFRPESR
.|..|.||.  . |.| 
vdetlgislvalvpase
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 113-329 9.5e-77 250.7 In-house 65-284 (287) alignment 
Range on Protein: 113-329
Range on HMM: 65-284/287.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
 .|||||||||||. |.||..|| .||.||| ...||||||| . .|. |||. |.. ... .||. |...|. .|.|| ... |.|||||||..| |..
vqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksld

QFSVFKRPLEIPDV--GVLTDLTWADPDPTEKGYKPS-ARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAA
..  .|.|    .   |.  || ||||.   |....   |. | |||   .  .|||||.....| |.|.|.||.|.  .||||.|||| |.|.. |..|
slkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlga

VFSIDKKLKISINVFRPESR
|  ..| |..|. |..||  
vvvvskslelsfvvlkpedf
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 113-330 3.5e-76 249.3 In-house 79-297 (299) alignment 
Range on Protein: 113-330
Range on HMM: 79-297/299.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDA-QLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
  .||||||||||   .|...|| . |. ||.|...||||||  ..|  |||| |.| || . .|.  ||. |...|.. .|.. |.|||||.| .|...
vnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
.|.  . || . |.  .  || ||||| . |.... .|| |.|||.  ..  ...||...| | ||||.||||||  ..|||||||| |||| ||.||..
dqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaim

SIDKKLKISINVFRPESRD
 .|..|  .. |..| ...
kvdenlvctfvvlkptpks
PPP_1 113-312 3.3e-74 242.5 In-house 56-263 (264) alignment 
Range on Protein: 113-312
Range on HMM: 56-263/264.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVN-YRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
..||||||||||| .|.|...||.|||| ||....|||||||||.|.. |||. ||  ..|....|. ....|.|.| .|.|.. |...|||.|..|.. 
tnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldll

NQFSVFKRPLEIPDVGVLTDLT-------WADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQN
.|    .|  |.|. | |.||.       . |.. .|.. . | |||...||. . . ||.| .|...|| |.|.|.||||.  |..||||||.||. . 
dqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeeg

DNTAAVFS
.|..|. .
snrgayvk
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 113-331 3.5e-73 239.5 In-house 58-278 (284) alignment 
Range on Protein: 113-331
Range on HMM: 58-278/284.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDA-QLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
  |||||||||||   .| ..|| | |. .|.....||||||   .|  |||| |.. ||.   .|  |. .| |.|. |.. . |.|||||.|. |   
anylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnv

NQFSVFKRPLEIPDVGVL-TDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAV
 |.   |||.. |.   |  |. |.||   .||..| .|| |.|||  ||| .| .|....|.| ||||.||||||  |||||||||| |||| ||.|||
sqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaav

FSIDKKLKISINVFRPESRDK
. ..|.|  |. |.||  .  
myvnknlvcsfvvlrprkkia
subfamily_PPP5C_pd Subfamily PPP5C 113-324 2.7e-67 220.1 In-house 94-306 (322) alignment 
Range on Protein: 113-324
Range on HMM: 94-306/322.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGI-SEHLTSF
. ||| ||.|||| ||.||...| ..|| ||....| |||||| ..|  |||  ||...| ..... |...|| .|.. |||. .. .|||. ||.  ..
npylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTeKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
...   .|  . |. |.| .| |.||... .| .|| || .. |||   . |||. .|...|| |.| |.|||. .  .|.|.||||||| | .| .|. 
ddlrkidrnaqppeegllvellwsdpqea.nGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafi

SI-DKKLKISINVF
.. ...||. .. |
tlrgddlklkfktf
subfamily_PPZ_pd Subfamily PPZ 113-326 8.5e-65 212.2 In-house 80-293 (300) alignment 
Range on Protein: 113-326
Range on HMM: 80-293/300.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
  |||||||||||  |.| ..|| . |. ||. ..|||||||   |   |||| |.. | . .... | . || .|..|..   |.|.|||.|  | |..
anylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmd

QFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFS
.     || ..||.|.. || |.||  . . ..   || |...   |.  ||.|. ...| | | |||||||||. | |||.||||||||. ||  ||.|
eirhvvrptdvpdfglindllwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavms

IDKKLKISINVFRP
. . |  |.... |
vsegllcsfelldp
subfamily_PPP6C_pd Subfamily PPP6C 113-326 1.1e-62 204.7 In-house 70-283 (290) alignment 
Range on Protein: 113-326
Range on HMM: 70-283/290.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRY-DAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
..|.||||.|||| .|.| . .| .||. ||||| ||||||||| .   |||| |   .| .|. .  . ..|.... .|.|.. ..|.|||.| ... .
tsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTEKgYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
.| .| .|  |||  | ..|| |.||.  |. .. | ||| ..||    . |..  .|....| ||.||.|....   .|||..|||||| .  | |...
dqirvieraqeiphkgafcdlvwsdpedvet.wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasil

SIDKKLKISINVFRP
..... . . ..|. 
aledaeereaklfka
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 113-332 2.4e-60 197.4 In-house 35-261 (263) alignment 
Range on Protein: 113-332
Range on HMM: 35-261/263.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDA-QL----YECFQNMFNVFPFCAVINNTIMCMHGGISEH
 .||||||||||| .|.||..|| .|||| | ...||||||| ...|  |||. |.. |..  ..    |. |...|. .|.||.... |.||||||| |
tqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhfnqvfsymplcaivskrilcmhggisph

LTSFNQFSVFKRPLEIPDVGVL-TDLTWADPDPTEKGYKPS-ARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQND
| |...      |||      |  || ||||.   ||..|   |  | |||   .  . |.||.....| ||||| || ||  |||.|.|||  |  .  
lkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielc

NTAAVFSIDKKLKISINVFRPESRDKK
| |||  ..| |..|.  ..||  . .
nyaavvvvnkmlelsfvqlkpedfevr
subfamily_PPP7C_pd Subfamily PPP7C 113-211 2.9e-29 95.0 In-house 93-193 (383) alignment 
Range on Protein: 113-211
Range on HMM: 93-193/383.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRY---DAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHlT
. |.| ||.||||  |.|....| || |.||  .|| |||||   .|  ||| .||. .|   .... . ....|  .|....|.. |. .|||||.. |
npyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.t

SF
..
dl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 114-326 1.5e-68 224.2 In-house 62-274 (280) alignment 
Range on Protein: 114-326
Range on HMM: 62-274/280.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFNQ
. .||||||||||  .||.||| .||. | |||||||||||. |||  |||| |..|.|   |.  ||. || .|....|.. ..|||||.|  |  .. 
klmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldt

FSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFSI
     || |  | |.| || |.||    .|.  | || |..||   .    | |.....||.||||.||||.. ||||.|.|| |||| |  |.|||  .
irniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvcl

DKKLKISINVFRP
. .|..|.. . |
nanlqvsfqqlip
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 114-328 1.3e-67 221.2 In-house 79-296 (297) alignment 
Range on Protein: 114-328
Range on HMM: 79-296/297.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDA-QLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
 ||||||||||| ||.| ..|| | |. .|  ..|||||||   ||  |||| |.. ||.. ..| .||..|| .|.. .| . |.|||||.|  ||   
nylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkef

---QFSVFKRPLEIpDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAA
    .  ..|. |    ....|| ||||     |.    |||   ||  |.     ...|..| | ||||.|||||| ||.|||||||| |||| || ||
tldtlrkiersteg.kerlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaa

VFSIDKKLKISINVFRPES
..| |.||. |....|| |
fmscdeklqcsfeilrpts
subfamily_PPP2C_pd Subfamily PPP2C 114-329 1.5e-67 220.8 In-house 73-288 (290) alignment 
Range on Protein: 114-329
Range on HMM: 73-288/290.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYD-AQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
 ||||||||||| .|.| | ||.|||. |..|| .|||||||| .   |||| |.  .|  |.... | ..|...|..|.... |.|.|||.| ......
nylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtld

QFSVFKRPLEIPDVGVLTDLTWADPDpTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFS
.   ..|  |.|. | |.|| |.|||   .|.  | ||| . ||    ..| |. .|....| ||.| .||..   |..|||||||||| .  | ||.. 
kiraldrlqevphegplcdllwsdpd.drggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaaile

IDKKLKISINVFRPESR
.|.||| |.. | | .|
lddklkysflqfdpapr
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 114-327 1.1e-65 214.5 In-house 72-289 (290) alignment 
Range on Protein: 114-327
Range on HMM: 72-289/290.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFNQ
..||||||||||. |.|| .||  .|. |. ...||||||| | ||. |||. |.  . ...|.  .|..|. ...|| ... |.|||||||... |.. 
kflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkieswes

FSVFKRPLEI--PDVGVLTDLTWADPDP--TEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAA
.  .|.|      | |.  || ||||.   ..       |. | |||  .|  .|||| |....| |.| |.|..|   ..|||.|||| |.|.. |  |
lkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlga

VFSIDKKLKISINVFRPE
.  . . |..|| |..|.
iatvseslelsivvlkpr
subfamily_PPG1_pd Subfamily PPG1 114-325 7.5e-63 205.6 In-house 70-294 (300) alignment 
Range on Protein: 114-325
Range on HMM: 70-294/300.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRY--DAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
 ||||||||||| .|.| ..||..||| || || ||||||||| .  .|||| |.  .|  ...... . ..|. .  .|.|.. |.|.|||.|    | 
nylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsi

NQFSVFKRPLEIPDVGVLTDLTWADPD---------PTEKG--YKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNY
.|  |. |  |.|. | |.|| |.||.         | ..|  .. | ||| . .|      ||.. |.. .|| ||.. .||. .   .| |..|||||
dqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapny

CGQNDNTAAVFSIDKKLKISINVFR
| .  | |..  . .|..  .||. 
cyrcgnkasilelyekderyfnvye
subfamily_PPPLV_pd Subfamily PPPLV 114-317 7.5e-49 159.6 In-house 57-280 (290) alignment 
Range on Protein: 114-317
Range on HMM: 57-280/290.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQL---YECFQNMFNVFPFCAVINNTIMCMHGGISEHLTS
 .||||||||||.||.|..  | |||. || ...||||||| .||  |. .. |  ...  .|   .| |.|.|...|  |||.....|.|.|| .   .
sllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimt

FNQFSVFKRPL-----EIPDVGVLTDLTWADPDPT-----------EKGYKP-SARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVT
  . |  .  |     .|    .  |. |.||.             ..|. . . || . ||.  || ||||. .|. |.| |.| | |...  . ||.|
qayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrllt

IFSAPNYCGQNdNTAAVFSIDKK-L
.||. .|||.  | ||.  .||| |
vfsssrycGss.neaalilvdkkkl
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 115-336 1.6e-57 188.0 In-house 77-301 (307) alignment 
Range on Protein: 115-336
Range on HMM: 77-301/307.0
YLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNY---RYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
|.| ||||||| .|.|...|| . |..||. | |||||||   ||  |||| |.     .   ...  ||  || .|  |.|   |.|||||.|  || .
yvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
...    .|.  |  |.. |. ||||||.   .| |.||. | ||   .    |.| ....|| ||.. |||  . ||.|.|||||| ||    |. .|.
delrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvl

SIDKKLKISINVFRPESRDKKRGFE
 .|. | | .  | ||| . ..  |
kvdetlgiqlvafvpeseniekiie
subfamily_PPP7C_pd Subfamily PPP7C 229-328 1.4e-18 59.8 In-house 237-336 (383) alignment 
Range on Protein: 229-328
Range on HMM: 237-336/383.0
LTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFSIDKKLKISINVFRPES
. |. |.||  .|     . ||.   |||   . .|.| .|...|| |.   .||||   ....||||| ||  .  |  |   . |.|.  |  .  ..
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqask