Gene W09D10.4 in Caenorhabditis elegans

Synonym: CELE_W09D10.4, W09D10.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PTC7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP201_AA protein Get Run
CeleP201_AA_77-328 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 78-328 1.6e-35 115.5 In-house 19-289 (295) alignment 
Range on Protein: 78-328
Range on HMM: 19-289/295.0
KDMLNGPSTVLDKGVFGDDAWFISR-----FKNTFVVGVADGVGGWRKYGIDPSAFSRRLMKECEKRVQKGDFDPQKPESLLDYAFRAS---------AE
  .  | ...  .    .||... .     .......||.||.||..   .  . . . |....|| ..  ....  .|. | .|| |          ..
lllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr

APRPVGSSTACVLVVHQEKLYSANLGDSGFMVVRNGKIVSKSREQVHYFNAPFQLTLPPEGYQGF------------IGDKADM----------------
  . ....||.|......||| ||.||| ....|||..|  .... ....  ..  | ..|.  .            .||   .                
pelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaeP

-ADKDEMAVKKGDIILLATDGVWDNLSEQQVLDQLKALDAGKSNVQEVCNALALTARRlafdskhnspfamkarehgflapGGKPDDITLVLLL
  .  |. ....|..|||.||.||.||.....| .. | |.  ...|....|.  | .                       .|. |.|| |.. 
dvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla.......................rgsrDNiTvvvvr
PP2Cc_SM00332 82-208 1.2e-12 40.8 In-house 12-149 (274) alignment 
Range on Protein: 82-208
Range on HMM: 12-149/274.0
NGPSTVLDKGVFGDDAWFISRF----KNTFVVGVADGvggwrKYGIDPSAFSRRLMKECEKRVQKGDFD--PQKPESLLDYAFRASAEAPRP--------
.| |.   . . . ||...       ... ..||.||     . | . . | .. . |. |.  |.. |   ...| .| .||..  |. .         
ygkssmqgwrksmeDahvvvvdlveeedwlffgvfDG.....hgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskele

--VGSSTACVLVVHQEKLYSANLGDSGFMVVRNGKIVSKSREQ
     |||.| ....|.|| ||.|||  ...||||.|. |...
nalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdh
PP2C_2 Protein phosphatase 2C 89-267 6.8e-10 31.6 Pfam-A 7-188 (212) alignment 
Range on Protein: 89-267
Range on HMM: 7-188/212.0
DKGVFGDDAWFISRFKNTFVVGVADGVGGWRkYGIDPSAFS-RRLMKECEKRVQKGDFD-PQKP-ESLLDYAF-------RA-SAEAPRPVGSSTACVLV
 || . .||..|.. ..  .. ||||.|  . ..   ...  . ...  || .......  ..  ....  .        .| .....    ..| ...|
rkgkpcqDalaireasdgwllaVADGaGsak.rSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllav

VHQEKLYSANLGDSGFMVV-RNGKIVSKSREQVHYF-NAPFQLTLPPEGYQGfigdkadmaDKDEMAVKKGDIILLATDGVWDNLSEQQVLD
.. ........||.. .|. |.|.. . . .... . |  . || . .. .          .  .. ...|| .|| ||||.|.|.... . 
itpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.........rirrlklepgdalllmTDGvsdslrkeepfr
PP2C_2 Protein phosphatase 2C 89-267 6.8e-10 31.6 In-house 7-188 (212) alignment 
Range on Protein: 89-267
Range on HMM: 7-188/212.0
DKGVFGDDAWFISRFKNTFVVGVADGVGGWRkYGIDPSAFS-RRLMKECEKRVQKGDFD-PQKP-ESLLDYAF-------RA-SAEAPRPVGSSTACVLV
 || . .||..|.. ..  .. ||||.|  . ..   ...  . ...  || .......  ..  ....  .        .| .....    ..| ...|
rkgkpcqDalaireasdgwllaVADGaGsak.rSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllav

VHQEKLYSANLGDSGFMVV-RNGKIVSKSREQVHYF-NAPFQLTLPPEGYQGfigdkadmaDKDEMAVKKGDIILLATDGVWDNLSEQQVLD
.. ........||.. .|. |.|.. . . .... . |  . || . .. .          .  .. ...|| .|| ||||.|.|.... . 
itpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.........rirrlklepgdalllmTDGvsdslrkeepfr
subfamily_PPTC7_pd Subfamily PPTC7 91-329 4.1e-102 333.9 In-house 8-251 (252) alignment 
Range on Protein: 91-329
Range on HMM: 8-251/252.0
GVFGDDAWFISRFKNTFVVGVADGVGGWRKYGIDPSAFSRRLMKECEKRVQKGDFDPQKPESLLDYAFRASAEAPRP-VGSSTACVLVVHQE--KLYSAN
  .|.||.|.|. |.. |.||||||||||..|||||.|||.|||.||| .........||..||..|.....|...| .||||||..|....  ||.|||
qkageDayfvsseksadvlgvADGVggWrsvGiDpsefsreLmkaceklskeskaeelkPvelleaayqelleekvpvlGssTacivvldksdkklesan

LGDSGFMVVRNGKIVSKSREQVHYFNAPFQLTLPPEGYQG-FIGDKADMADKDEMAVKKGDIILLATDGVWDNLSEQQVLDQLKAL-DAGKSNVQEVCNA
||||||.|||.||.| .|.|| |.||.|.||...|||..| .| ||...||. ..||||||||.|||||..|||.|...|..||.| .. ||..|.....
lGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapegregkvildkpeaadsksfavkkgDiivlatDGlfDNlledeileilkelkeseksslqslakk

LALTARRLAFDSKHNSPFAMKAREHGFLAPGGKPDDITLVLLLI
|| .||.|..|....||||.||...|. | ||||||||.|. ..
laekarelsldpeyespfaqkakkngleasGGKpDDitvvvavv
0049733 PP2C-like 91-328 1.8e-37 122.0 In-house 15-232 (235) alignment 
Range on Protein: 91-328
Range on HMM: 15-232/235.0
GVFGDDAWFIsrfkNTFVVGVADGVGGWRKYGIDPSAFSRRLMKECEKrvqkgdFDPQKPESLLDYAFRAS---------AEAPRPVGSSTACVLVVHQE
   ..||...    ......||||.||..  ..  . . . |......      ... ..| .|  ||.|          |. .. .. .||.|......
rkvneDavlv....glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspelagmgtTavvalldgg

KLYSANLGDSGFMVVRNGKIVSKSREQVHYFNAPFQLTLPPEGYQGF---------IGDKADMADKDEMAVKKGDIILLATDGVWDNLSEQQVLDQLKAl
||| ||.||| ....|.||.|  .... .... ..|  . ..|.  .         .||    .|  .. ...||..|||.||.||.||.....| |.  
klyvanvGDsrayllrdgklvqltedhspvnelerqriitaggavrvpgrlaltralGdlllkpdvtvlelepgdflllasDGlwdvlsdeeivdllrs.

dagkSNVQEVCNALALTARRlafdskhnspfamkarehgflapGGKPDDITLVLLL
     ...|....|. .|..                       .|..|.||.|.. 
....ldleeaaerlvelala.......................rggrDNiTvvvvr
PP2C_SIG_SM00331 94-327 5e-20 65.0 In-house 17-215 (217) alignment 
Range on Protein: 94-327
Range on HMM: 17-215/217.0
GDDAWFISRFKN-TFVVGVADGVGgwrkYGIDPSAFSRRLMKECEKRVQKGdfdpQKPESLLDYAFRASAEA-PRPVGSSTACVLVV--HQEKLYSANLG
. |  ..   .. .... ||||.|     |.. .|.|..| .  .. ...|    . ....|  . ||  |      .  |......   . ||. ||.|
sGDyydvvklnegrlllvvaDgmG....kGlaAaaassqlrtalrellseg....eelsqalkrlnraiyeekeekgmfaTlllalydfssgklsyanaG

DSGFMVVRNGKIVSKSREqvhyfNAPFQLTLPPEGYqgfigdkadmADKDEMAVKKGDIILLATDGVWDNLSEQQvLDQLKALDAGKSNVQEVCNALAL-
|| . ..|.|| | .  .     .....| | ||            .|  |. ..|||..||.|||.... ||.. ... .  .. ...|.. . .||  
dsrpyllrdgklveilkd.....vegaplGlepevs..........vdirelelekgdllllytDGltearsekg.faeerleeiledlvdseaqelaqk

---TARRLAFDSKHnspfamkarehgflapggkPDDITLVLL
    . .|| .|.                    .||||.|..
iveellelakgsng...................eDdiTvvvv
SpoIIE Stage II sporulation protein E (SpoIIE) 106-327 5e-16 51.1 Pfam-A 4-190 (193) alignment 
Range on Protein: 106-327
Range on HMM: 4-190/193.0
TFVVGVADGVGgwrkYGIDPSAFSRRLMKECEKRVqKGDFDpqkPESLLDYAFRAS-AE---AprpVGSSTACVLV--VHQEKLYSANLGDSGFMVVRNG
.....|.|.||     |.. ......| .  .. . . . .   |. .|. . .|  ..   .   .   ||....   ...||. ||.|.. ...||. 
rlalvvgDvvG....hGleAalimgllrsalrela.tagle...paevlerlnealarnleee...erfatavlaeydpstgkleyanaGhpppllvrpd

KivsKSREQVHYFNAPfqLTLPPEgyqgfigdkaDMADKDEMAVKKGDIILLATDGVWDNLSEQQVL----DQLKALD--AGKSnVQEVCNALALTARRl
.   . ... . ...|  | . ||            ... |. ...||..||.|||| .. .... |    ..|..|.  .|.| ..|...||  .... 
g...gtkfllvstglp..lGilpe..........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaeges.leelldalveelle.

afdskhnspfamkarehgfLAPGGKPDDITLVLL
                   |  |.. |||||..|
...................lgsgeleDDitllvl
SpoIIE Stage II sporulation protein E (SpoIIE) 106-327 5e-16 51.1 In-house 4-190 (193) alignment 
Range on Protein: 106-327
Range on HMM: 4-190/193.0
TFVVGVADGVGgwrkYGIDPSAFSRRLMKECEKRVqKGDFDpqkPESLLDYAFRAS-AE---AprpVGSSTACVLV--VHQEKLYSANLGDSGFMVVRNG
.....|.|.||     |.. ......| .  .. . . . .   |. .|. . .|  ..   .   .   ||....   ...||. ||.|.. ...||. 
rlalvvgDvvG....hGleAalimgllrsalrela.tagle...paevlerlnealarnleee...erfatavlaeydpstgkleyanaGhpppllvrpd

KivsKSREQVHYFNAPfqLTLPPEgyqgfigdkaDMADKDEMAVKKGDIILLATDGVWDNLSEQQVL----DQLKALD--AGKSnVQEVCNALALTARRl
.   . ... . ...|  | . ||            ... |. ...||..||.|||| .. .... |    ..|..|.  .|.| ..|...||  .... 
g...gtkfllvstglp..lGilpe..........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaeges.leelldalveelle.

afdskhnspfamkarehgfLAPGGKPDDITLVLL
                   |  |.. |||||..|
...................lgsgeleDDitllvl
PPM_PTC7_SpoIIE 107-326 3.5e-18 59.3 In-house 33-226 (230) alignment 
Range on Protein: 107-326
Range on HMM: 33-226/230.0
FVVGVADGVGgwrkYGIDPSAFSRRLMKECEKRVqKGDFDpqKPESLLDYAFRASAEAPRPV---GSSTACVLVVHQEK--LYSANLGDSGFMVVRNGKI
 .. |.|..|     |.. ......| .  ...  . ...  ||| .|  ...| | . .     . .||.|.... ..  || ||.||| ...||... 
lalvvgdvdG....hGgraalamgllrtalrela.fagle..kpeeilrrlnlalaadledepsssgaTavvalidpstgklyvanaGdsppllvrddgg

vskSREQVHYFNAPFqLTLPPEgyqgfigdkaDMADKDEMAVKKGDIILLATDGVWDNL--SEQQVL----DQLKALDAG---KSNVQEVCNALALTARR
    ||..  ...|  | . |.            ... ... ..||..||.|||| ..   ...  |    . | ....|   . . ||.. ..  .  .
...ererivagglps.lGilpg..........rvfgvlavslapGdllllytDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelek

LafdskhnspfamkarehgfLAPGGKPDDITLVL
.                   .| |.. |||||. 
p...................aaeglleDDitllv
subfamily_PPM1E_pd Subfamily PPM1E 108-202 2.4e-06 20.0 In-house 42-135 (265) alignment 
Range on Protein: 108-202
Range on HMM: 42-135/265.0
VVGVADGVGGwrkygIDPSAFSRRLMKECEKRVQKGDFDPQK----PESLLDYAFRASAEAPRPVGSSTACVLVVHQEKLYSANLGDSGFMVVRNGKIV
. .| || ||     .. . .. . ..| . | .|   ||..       |.| .| . ||  .  . ||| | ......|| | ||||  ..||.|..|
ffavfDGHgG.....veaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklksGstavvvliekdqlyvaWlGDsqallvrkgeav
PPM_PTC7 116-202 1.8e-09 30.4 In-house 32-134 (259) alignment 
Range on Protein: 116-202
Range on HMM: 32-134/259.0
GGWRKYGIDPSAFSRRLMKECEKRVQ-----KGDFDPQ-KPESLLDYAFRA--SAE---------APRPVGSSTACVLVVHQEkLYSANLGDSGFMVVRN
  .. ...  ....|.. | .....      . .|..  |.|  |  .|.|   .|         .|  .||.  ..|..... || ||.|||.....|.
dsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsGstAvvalitgsk.lyvAnvGDSravLcrs

GKIV
|..|
gnav
PP2C Protein phosphatase 2C 155-202 8.7e-08 25.0 Pfam-A 85-133 (255) alignment 
Range on Protein: 155-202
Range on HMM: 85-133/255.0
DYAFRAS---AeAPRPVGSSTACVLVVHQEkLYSANLGDSGFMVVRNGKIV
|. .. |   . .|  .||.  ..|..... || ||.|||  ...|.....
deelksskant.epsksGstavvalirgkk.lyvAnvGDSravLcrkdnak
PP2C Protein phosphatase 2C 155-202 8.7e-08 25.0 In-house 85-133 (255) alignment 
Range on Protein: 155-202
Range on HMM: 85-133/255.0
DYAFRAS---AeAPRPVGSSTACVLVVHQEkLYSANLGDSGFMVVRNGKIV
|. .. |   . .|  .||.  ..|..... || ||.|||  ...|.....
deelksskant.epsksGstavvalirgkk.lyvAnvGDSravLcrkdnak
subfamily_ILKAP_pd Subfamily ILKAP 155-199 7e-06 18.4 In-house 97-143 (293) alignment 
Range on Protein: 155-199
Range on HMM: 97-143/293.0
DYAFRASAEAPRP--VGSSTACVLVVHQEKLYSANLGDSGFMVVRNG
|  | . |.. .|     ||| |..| .. ||.||||||  ..||. 
deefLklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkk
subfamily_PPM1H_pd Subfamily PPM1H 158-207 1.7e-06 20.1 In-house 151-200 (404) alignment 
Range on Protein: 158-207
Range on HMM: 151-200/404.0
FRASAEAPRPVGSSTACVLVVHQEKLYSANLGDSGFMVVRNGKIVSKSRE
 .   || |  |  ||.| .| ..||| || |||  ..||...|.  |..
iarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsad
subfamily_PPM1G_pd Subfamily PPM1G 165-205 7.5e-06 18.2 In-house 292-332 (473) alignment 
Range on Protein: 165-205
Range on HMM: 292-332/473.0
PRPVGSSTACVLVVHQEKLYSANLGDSGFMVVRNGKIVSKS
|     .||.| .....||. || |||  .. |||| .  |
pGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldls
subfamily_PPM1A_pd Subfamily PPM1A 170-204 8e-06 18.4 In-house 116-150 (282) alignment 
Range on Protein: 170-204
Range on HMM: 116-150/282.0
SSTACVLVVHQEKLYSANLGDSGFMVVRNGKIVSK
 ||| ...|....|. ||||||  ...|||| . .
GsTavtvlvsekhliianlGDsRavlcrngkaafl
subfamily_CG9081_pd Subfamily CG9081 180-263 4e-07 20.4 In-house 105-191 (195) alignment 
Range on Protein: 180-263
Range on HMM: 105-191/195.0
QEKLYSANLGDSGFMVV-RNGKIVSKSREQVHYFNAPFQLTLPPEGYQGFIGDKADMADK--DEMAVKKGDIILLATDGVWDNLSEQ
|  |.....|||  .|  .. | |     ..|  .   .  |.       || ..|. .     ..|..|||..| .||| ||.  .
qWglfvvsvGdspvfvyspdnksvrevtvashskdgirdvrlsGGalGpaiGtdpdlenlslsylpvaeGdivfltsdGvsdnfdPv
subfamily_Sponge-PPM-1_pd Subfamily Sponge-PPM-1 203-263 1.9e-06 17.6 In-house 130-192 (199) alignment 
Range on Protein: 203-263
Range on HMM: 130-192/199.0
SKSREQVHYFNAPFQLTLPPEGYQGFIGDKADMADK--DEMAVKKGDIILLATDGVWDNLSEQ
 .   ..|  .   .  |        || ..|. .     . |..|||.|| |||. ||.. .
heatvachdkdGirtarlsGGalGpaiGtdpdlenlslsylpvaeGdivllttdGisdnfapv
PPM_PTC7_SpoIIE_motif 237-327 3.6e-12 39.8 In-house 3-78 (81) alignment 
Range on Protein: 237-327
Range on HMM: 3-78/81.0
DKDEMAVKKGDIILLATDGVWDNLSEQQVL----DQLKALD--AGKSnVQEVCNALALTARRlafdskhnspfamkarehgfLAPGGKPDDITLVLL
|  |  .|.||..||.|||.... ...  |    . |...|   |||  ||.. .|  ....                    .. |.. |||||..|
deaefqLkpgdvllLyTDGltEardsdgelfgkeellrladraegks.lqeladklvdevle....................ngsgereDDitllvl
PP2Cc_SM00332 243-326 9.1e-10 31.4 In-house 210-273 (274) alignment 
Range on Protein: 243-326
Range on HMM: 210-273/274.0
VKKGDIILLATDGVWDNLSEQQVLDQLKALDAGKsnvqevcnalaltarrlafdsKHNSPFAMKAREHGFLAP-GGKPDDITLVL
 .......||.||.||.||.|.| | ...| | .                     |.|.| .. ..    ... ||. |.|| |.
tsedeflilaSDGlwdvlsnqevvdivrkllakg.....................ktndpqeaaelldeeairrggseDniTvvv
subfamily_PPM1G2_pd Subfamily PPM1G2 244-287 4.3e-06 18.9 In-house 218-261 (287) alignment 
Range on Protein: 244-287
Range on HMM: 218-261/287.0
KKGDIILLATDGVWDNLSEQQVLDQLKALDAGKSNVQEVCNALA
.. . ..|| ||.|| |....|.| ..   . . ...|... | 
eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieell
subfamily_PPM1A_pd Subfamily PPM1A 245-290 1.4e-06 20.9 In-house 219-264 (282) alignment 
Range on Protein: 245-290
Range on HMM: 219-264/282.0
KGDIILLATDGVWDNLSEQQVLDQLKALDAGKSNVQEVCNALALTA
. | ..|| ||.|| ||...|..  .     .....||..||  .|
eddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdka
PP2C Protein phosphatase 2C 247-291 8e-06 18.6 Pfam-A 203-247 (255) alignment 
Range on Protein: 247-291
Range on HMM: 203-247/255.0
DIILLATDGVWDNLSEQQVLDQLKALDAGKSNVQEVCNALALTAR
. ..||.||.|| ||.|.. |  .     |.. .|....|.  | 
efliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeai
PP2C Protein phosphatase 2C 247-291 8e-06 18.6 In-house 203-247 (255) alignment 
Range on Protein: 247-291
Range on HMM: 203-247/255.0
DIILLATDGVWDNLSEQQVLDQLKALDAGKSNVQEVCNALALTAR
. ..||.||.|| ||.|.. |  .     |.. .|....|.  | 
efliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeai
PPM_PTC7_motif 250-294 7.1e-09 29.0 In-house 1-46 (51) alignment 
Range on Protein: 250-294
Range on HMM: 1-46/51.0
LLATDGVWDNLSEQQVLDQLKAL-DAGKSNVQEVCNALALTARRLA
.||.||.||.||.|.. |...   .. .   ||... |. .|.  .
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealarg