Gene Y54F10BM.1 in Caenorhabditis elegans

Synonym: CELE_Y54F10BM.1, Y54F10BM.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP220_AA protein Get Run
CeleP220_AA_10-334 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G2_pd Subfamily PPM1G2 5-333 5.6e-34 110.4 In-house 3-286 (287) alignment 
Range on Protein: 5-333
Range on HMM: 3-286/287.0
SEPMARTPIQFGENMRITVAA--SQGGRRYMEDRCVIHTERIN-NGLLDWTFVGVFDGHGGEHASEYVRRHLLMNITKNQKFEsnsDEDILEAIRQGFLM
|||.     . ..|. ..|..   || |. |||  ....| .. .   . ....|||||||.....|. ..|   |.|...|.   .. . ......|| 
sepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafle

THEQMRHVydewpytASGYPSTAGTTVSCVFIRNGKLYTGHVGDSAIFLGTVENgelhSRPLTTDHKPESVHEQLRIAKAGGETAVKSGVTRVVWKRpqK
| |....         .   ..||.|   | |.. ||| . .|||   | .  |    .. |. ||||.. .|. || .|||  ...     .   |   
tDeellkd.......eklkdesaGstavvvlikeeklyvanaGDsravlsskgn....vkalsfDhkPqeesekkriiaagGfvelnrvngnLalsr..a

MSQFMMMTSNSneqkhhqnpqimenipflsvarslgdlwsynEKTNMFIVSPEPDLGVHRLTGNDFCLVLASDGMTNVMTGDQAISIVFKEEEMVEIHEE
.. |.  ....                                | .  ||  .||. |..|. .|  |||| ||. .|.| .. . .| ..  .    .|
lgDfefkknvk...............................kkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgaklde

INRN-HSRCVLRSAlqKWRSLRADNVTIATVIF
| ..  ..|. ...  .  .. .||.|.  |..
iieelldkclapds..sntgvGcDnmtvvivvl
0034914 PP2C-like 11-334 2.6e-51 167.2 In-house 13-291 (295) alignment 
Range on Protein: 11-334
Range on HMM: 13-291/295.0
TPIQFGENMRITVAASQGGRRYMEDRCVIHTERIN--NgllDWTFVGVFDGHGGEHASEYVRRHLLMNITKN----QKFESNSDEDILEAIRQGFLMTHE
. . .  ..|. ||  || |...||....... ..  .   |....|||||||| .|.|.....|. .. ..    . . ..|.|||.||.|..|| ..|
llsslllllrvgvasdqGrrksneDavlvvlnllslle...dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaade

QMRHVYDEWpytasGYPSTAGTTVSCVFIRNGKLYTGHVGDSAIFLGtvENGelHSRPLTTDHKPESVHEQLRIAKAGgetavksgvtrV-------Vwk
....   ..      . .. |||.....||..|||...|||| ..|    ||  . ..||.|||| .  |. || .||                      
ellelallr.....pelagsGtTavvalirgnklyvanvGDSravll..rng..elvqltvdhkpvnelererilsag...........gavshgrvn..

rpqkmsqfmmmtsnsneqkhhqnpqimeniPFLSVARSLGDLWSYNEKTN---MFIVSPEPDLGVHRLT-GNDFCLVLASDGMTNVMTGDQAISIVFK--
                              ..| | |.||| . .. ...    ..||.|||. |..|| ..| .|.|||||...|.. .....|| .  
..............................gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsll

--EEEmveiheeiNRNHSRCVLRSALQkwrSLRADNVTIATVIFD
    .          . .. ... ||.       ||.|.  | ..
akgld........leeaaeeLvdlAla...rgsrDNiTvvvvrln
subfamily_PPM1G_pd Subfamily PPM1G 14-107 1.6e-12 40.2 In-house 14-100 (473) alignment 
Range on Protein: 14-107
Range on HMM: 14-100/473.0
QFGENMRITVAASQGGRRYMEDRCVIhterINNGLLDWTFVGVFDGHGGEHASEYVRRHLLMNITKNQKFEsnsDEDILEAIRQGFLMTHEQMR
.. |... ...| || |  .||        | .   |... .|.|||||.  ..|| ..|.  ..... ..   ..|. .|... ||   |...
esneelsygasamqGwrvsqEDahnc....itdldedtslfavyDGHGGkevakyvakklpdllkaqkgyk...egdvekaleeaflalDeklk
subfamily_PPM1A_pd Subfamily PPM1A 16-334 5.8e-48 156.7 In-house 9-281 (282) alignment 
Range on Protein: 16-334
Range on HMM: 9-281/282.0
GENMRITVAASQGGRRYMEDRCVIHTErINnGLLDWTFVGVFDGHGGEHASEYVRRHLLMNITKNQKF-----ESNSDEDILEAIRQGFLMTHEQMRHVY
|...|..|.. || |. |||. .. .. .. .| ||.|  |||||.|.....|| .||| ||......     |........||.||||| ..|..|.  
gnglrygvssmqgwrvemEDahtvvas.lg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairels

DEWPYTA-SgypstaGTTVSCVFIRNGKLYTGHVGDSAIFLgtVENGELHSrpLTTDHKPESVHEQLRIAKAGGETAvksgVTRVVWKrpqkmsqfmmmt
..   .  |      |.|. .|.... .|.. ..||| ..|  ..||. .   ||.||||.. .|. || .|||.      | ||  .            
tdlktadks......GsTavtvlvsekhliianlGDsRavl..crngkaaf..lteDHkpsrpkEkkRieqAGGsvv....vsRvnGa............

snsneqkhhqnpqimenipfLSVARSLGDLwSYNE----KTNMFIVSPEPDL-GVHRLTGNDfCLVLASDGMTNVMTGDQAISIVFKEEEMVEIHEEInr
                    | |.|.|||  .|.|    |..   ||.||.   ..| . .|  ||||.||.  |.. ......| |. |. .  ||.  
....................LAvsRalGDy.eykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleev..

nhSRCVLRSALQKWRslrADNVTIATVIFD
  .. ... ||.|      ||...  |.|.
..akalvdkalekgs...rDNlsvlvvlfa
subfamily_PPM1D_pd Subfamily PPM1D 18-334 3.2e-134 439.9 In-house 1-308 (309) alignment 
Range on Protein: 18-334
Range on HMM: 1-308/309.0
NMRITVAASQGGRRYMEDRCVIHTERINNGL-LDWTFVGVFDGHGGEHASEYVRRHLLMNITKNQKFESNSDEDILEAIRQGFLMTHEQMRHVYDEWPYT
....|..|.||||.||||...|..|. .... |...||.|||||||..|....|.||...|.|..|| |...||.|||||..||.|||.|.....|||.|
slsvtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpkt

ASGYPSTAGTTVSCVFIRNGKLYTGHVGDSAIFLGTVEN--GELHSRPLTTDHKPESVHEQLRIAKAGGETAVKSGVTRVVWKRPQkmsqfmmmtsnsne
.||..||||||.|.|.||. |||..|||||||.||. |.   .|....||.||||||..|. ||...|||.|.||||.|||||||.              
ksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRpr..............

qKHHQNPQIMENIPFLSVARSLGDLWSYNEKTNMFIVSPEPDLGVHRLTGNDF-CLVLASDGMTNVMTGDQAISIVFKEEEMVEIHEEINRNHSRCVLRS
 ..|..|.....||||.||||||||||||.|...|.||||||. |..|..|.. ...|||||..||.|...|.|.| ||||. |..|| .|.........
.lehngptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvke

ALQKWRS--LRADNVTIATVIFD
|||.|||  ||||||....||..
alqrwrskklraDnvsvivvile
0049733 PP2C-like 19-333 7.1e-38 123.3 In-house 3-233 (235) alignment 
Range on Protein: 19-333
Range on HMM: 3-233/235.0
MRITVAASQGG-RRYMEDRCVIhterinngllDWTFVGVFDGHGGEHASEYVRRHLLMNITknQKFESNSDEDILEAIRQGFLMTHEQMRHVYDEWPyta
... .|  .|  |...||....          ......|.||||| .|.|.....|. ..   . ... . .|..||.|. ||...|.... . ..|   
lsvgaasdigrvrkvneDavlv..........glllfavaDGhgghaagevasellvetll..elllelllldleealrkaflaaneallelalasp...

sgYPSTAGTTVSCVFIRNGKLYTGHVGDSAIFLGTveNGElhSRPLTTDHKPESVHEQLRIAKAGGETavksgvtrvvwkrpqkmsqfmmmtsnsneqkh
    .. |||........||||. .|||| ..| .  .|.   ..||.||.|    |. || .|||                                  
..elagmgtTavvalldggklyvanvGDsrayllr..dgk..lvqltedhspvnelerqriitaggav................................

hqnpqimENIPFLSVARSLGDLWSYnektnmfivspePDLGVHRLTGNDfCLVLASDGMTNVMTGDQAISIVFKeeemveiheeIN-RNHSRCVLRSALQ
         .. | . |.||||.              ||. |..|. .| .|.|||||...|.. ....... .           . ..  ..... ||.
.......rvpgrlaltralGdlllk............pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs..........ldleeaaerlvelala

KWRSlraDNVTIATVIF
..     ||.|.  | .
rggr...DNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 19-194 4e-26 84.8 In-house 4-167 (265) alignment 
Range on Protein: 19-194
Range on HMM: 4-167/265.0
MRITVAASQGGRRYMEDRCVIHTErIN-----NGLLDWTFVGVFDGHGGEHASEYVRRHLLMNITKNQKFESNSDedilEAIRQGFLMTHEQMRHvydew
.....|| .. || ||||.|.  . .|     ..  . .| .||||||| .|..|  .||  .. ...|.....     ||....| .| |.. .     
yevsiaavknkrrkmEDrhvaled.lnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa....ealkeafkltDerflq.....

pyTASGYPSTAGTTVSCVFIRNGKLYTGHVGDSAIFLgtVENGELhsRPLTTDHKPESVHEQLRIAKAGGETAVKsGVTRV
  .|     ..|.|  .|.|.. .|| . .|||  .|  |..||   . |.. ||||   |. ||..|||   |  |. ||
..kaereklksGstavvvliekdqlyvaWlGDsqall..vrkgea..vqlmkpHkPeredEkkRieeagGlvvvi.gawRv
PP2Cc_SM00332 20-331 1.6e-50 165.0 In-house 11-274 (274) alignment 
Range on Protein: 20-331
Range on HMM: 11-274/274.0
RITVAASQGGRRYMEDRCVIHTERInnGLLDWTFVGVFDGHGGEHASEYVRRHLLMNITKNQKFESNS-DEDILEAIRQGFLMTHEQMRHVYDEWPYTAs
.  ....|| |. |||..|....       ||.|.||||||||. ....|...|  .. .. |....  ..|. ||....|| |.|.... .. .     
sygkssmqgwrksmeDahvvvvdlv..eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen.

gypSTAGTTVSCVFIRNGKLYTGHVGDSAIFLGTVENgelhSRPLTTDHKPESVHEQLRIAKAGGetavksgvtrvvwkrpqkmsqfmmmtsnsneqkhh
   ...|.|..........||  .|||| ..|.. ..    ...|..|||||   |  || ||||                                   
...alsGstavvallkkedlyvanvGDSravlcrngk....avqlsvdhkpedederkRikkagg...................................

Q---NpqimENIPFLSVARSLGDLWSY-NEKTNMFIVSPEPDLGVHRLTGNDFCLVLASDGMTNVMTGDQAISIVFKEE--EMVEIHEEINRNHSRCVLR
.   .         |.| |..|| .   |.| .  ....|||  |..|| .| .|.||||| ..|.. .....|| | .  .  .  .|.  .  ....|
vvekg....rvngglavsrafGdhflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeair

SalqkwrSLRADNVTIATV
.         .||.|. .|
r......ggseDniTvvvv
subfamily_PPM1L_pd Subfamily PPM1L 20-194 1.5e-23 76.4 In-house 6-172 (269) alignment 
Range on Protein: 20-194
Range on HMM: 6-172/269.0
RITVAASQGGRRYMEDRCVIHTERINNglLDWTFVGVFDGHGGEHASEYVRRHLLMNITkNQKFESNSDEDILEAIRQGFLMTHEQMRhVYDEWPYTASG
...| . .| |  ||||  |...  |.   . .|..|||||||| |.|...  |  .|  |.  | ..| .  | |  . |.|.| .  |  .   .|  
qvavysvlGrrprmedrfeieediknk..tgesffavfdGhGGefaaefakdvlvkaik.nklieldadkentepinfsklltdeils.vdekllekakr

YPSTAGTTVSCVFIRNGKLYTGHVGDSAiflGTVENGELHSRPLTTDHKPESVHEQLRIAKAGGETAVKsGVTRV
   .||||.   .... .|    ||||    | . . . .. ||. ||||. |.|. || ||||  | . || ||
aediaGttalialvqesdlivanvGdsr...GvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafr.Gvwrv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 20-194 6.6e-20 64.5 In-house 7-162 (255) alignment 
Range on Protein: 20-194
Range on HMM: 7-162/255.0
RITVAASQGGRRYMEDRCVIHTERINNGLLDWtfVGVFDGHGGEHASEYVRRHLlMNITKNqKFESNSDeDILEAIRQGFLMTHEQMrhvydewpytaSG
... .   | |  |||. ||. .  ..   |.  . .||||||..|...   .|  .| .. ... |.  . ...... .  .. |.           | 
kvgfsdmiGrrptmedelviyGsfrdksdedy..yalfdGhgGraaakfaseel.ykilae.lldlnna.nPvkslkkaykeistqi...........se

YPSTAGTTVSCVFIRNGKLYTGHVGDSAIFLGTVENgelHSRPLTTDHKPESVHEQLRIAKAGGETAVKSGVTRV
.|   |||   |.| . | |   |||| . |.  .     .. |. ||||   .|..||...||    .   .||
rpkfiGttaasvliiedkvyianvGdsrvvlcqkdg...takrlsldhkPseeseekriselGGtvvstvvtsrv
subfamily_ILKAP_pd Subfamily ILKAP 21-184 9.4e-21 67.2 In-house 7-175 (293) alignment 
Range on Protein: 21-184
Range on HMM: 7-175/293.0
ITVAASQGGRRYMEDRCVIHTERI------NNGLLDWTFVGVFDGHGGEHASEYVRRHLLMNITKNQKFESNSDEDilEAIRQGFLMTHEQMRHVYDEwp
 ..|  .| |  |.| .||  .        .. .   .. .|||||.|..|||.. ..|  .| ..   .. | ..  . |.. .. ....  . . .  
gayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsake..keikkclvdsfkktdeefLk..

YTASGYPS-TAGTTVSCVFIRNGKLYTGHVGDS-AIFLGTVENGE-LHSRPLTTDHKPESVHEQLRIAKAGGE
  ... |.   |.|. .|.. .  ||.. .||| |... . |.|. . | .|| ||.| .  |. || |||| 
laskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgv
subfamily_PPM1K_pd Subfamily PPM1K 21-190 5.1e-19 61.4 In-house 6-161 (263) alignment 
Range on Protein: 21-190
Range on HMM: 6-161/263.0
ITVAASQGGRRYMEDRCVIHteRINNGLLdwtFVGVFDGHGGEHASEYVRRHLLMNITKNQkfesNSDEDILEAIRQGFLMTHEQM-RHVYDEWPYTasg
. ... .| |.  |||  ..  .... ||   .|.|||||.|  | ..|  .|   ...      . ..|. . ... |.  .... |... ... .   
vGkdsliGkraenedriklk..eldpell...yvavfdGhaGsaaadfvhdklekilkrll....ekekdleivlknafeeldkklkrylefsvaea...

YPSTAGTTVSCVFIRNGK-LYTGHVGDSAIFLgtVENGElhSRPLTTDHKPESVHEQLRIAKAGGETAVKSG
   ..||| . ...|.|. |    .|||   |    ||.  .. ||.||.||  .|. || .|||  . .| 
ellssGttatvsllrdGtelvlaslGdsrail..crnGk..akkltrdhdPeleeekerikaagGsvewnsl
PP2C Protein phosphatase 2C 22-305 1.5e-50 165.2 Pfam-A 4-241 (255) alignment 
Range on Protein: 22-305
Range on HMM: 4-241/255.0
TVAASQGGRRYMEDRCVIHT-ERINNGLLDWTFVGVFDGHGGEHASEYVRRHLLMNITKNQKFESNSdeDILEAIRQGFLMtHEQMRHVYdewPYTASgY
.. . || |. |||....    . ..|  .. |..|||||||..|..| | ||   . ....|..    .  .|.|..||  ......     . ...  
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.e

PSTAGTTVSCVFIRNGKLYTGHVGDSAIFLGTVENGElhsRPLTTDHKPESVHEQLRIAKAGGETAVksgVTRVVWKrpqkmsqfmmmtsnsneqkhhqn
||. |.| ....||. |||. .|||| . |..  | .     ||.||||..  |  || .|||.      ..||...                       
psksGstavvalirgkklyvAnvGDSravLcrkdnak...keltedHkpsdedEreRIeeaggsvsn...ngrvngs.......................

pqimenipfLSVARSLGDLWSYNEKtnMFIVSPEPDLGVHRLTGNDFCLVLASDGMTNVMTGDQAISIVFKEEEMVEIHEEINRN
         |.|.|.|||.......   ..||.|||. ...|| .| .|.|||||...|.. ..|...| .|..  .  .|....
.........LavsRalGdfelkpke..eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaee
PP2C Protein phosphatase 2C 22-305 1.5e-50 165.2 In-house 4-241 (255) alignment 
Range on Protein: 22-305
Range on HMM: 4-241/255.0
TVAASQGGRRYMEDRCVIHT-ERINNGLLDWTFVGVFDGHGGEHASEYVRRHLLMNITKNQKFESNSdeDILEAIRQGFLMtHEQMRHVYdewPYTASgY
.. . || |. |||....    . ..|  .. |..|||||||..|..| | ||   . ....|..    .  .|.|..||  ......     . ...  
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.e

PSTAGTTVSCVFIRNGKLYTGHVGDSAIFLGTVENGElhsRPLTTDHKPESVHEQLRIAKAGGETAVksgVTRVVWKrpqkmsqfmmmtsnsneqkhhqn
||. |.| ....||. |||. .|||| . |..  | .     ||.||||..  |  || .|||.      ..||...                       
psksGstavvalirgkklyvAnvGDSravLcrkdnak...keltedHkpsdedEreRIeeaggsvsn...ngrvngs.......................

pqimenipfLSVARSLGDLWSYNEKtnMFIVSPEPDLGVHRLTGNDFCLVLASDGMTNVMTGDQAISIVFKEEEMVEIHEEINRN
         |.|.|.|||.......   ..||.|||. ...|| .| .|.|||||...|.. ..|...| .|..  .  .|....
.........LavsRalGdfelkpke..eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaee
PPM_PTC7 22-301 5.5e-50 163.2 In-house 4-241 (259) alignment 
Range on Protein: 22-301
Range on HMM: 4-241/259.0
TVAASQGGRRYMEDRCVIHT-ERINNGLLDWTFVGVFDGHGGEHASEYVRRHLLMNITKNQKFESNSdeDILEAIRQGFLMTHEQMRHVYdewPYTASgY
 . | || |. |||....    . ..|  .. |..||||||| .|..|.| ||   . ... ||.    .  .|.| .||  .  ...     . ...  
gasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks...seant.e

PSTAGTTVSCVFIRNGKLYTGHVGDSAIFLGTVENGElhsRPLTTDHKPESVHEQLRIAKAGGETAVKsGVTRVVWKrpqkmsqfmmmtsnsneqkhhqn
||| |.| ....|.. |||. .|||| . |.. .|      .||.||||..  |  || .|||.   . |..||...                       
pstsGstAvvalitgsklyvAnvGDSravLcrsgnav...kqltedHkpsnedEreRiegaggsvsnv.gngrvngv.......................

pqimenipfLSVARSLGDLWSYNEKTNMFIVSPEPDLGVHRLTGNDFCLVLASDGMTNVMTGDQAISIVFKEEEMVeIHEE
         | |.|..||..... .|  . ||.|||  .. .. .| .|.||||| ..|.. ..|...| .|..     .|
.........lavsRafGdfelkpketeeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpme
Subfamily Dicty-PPM1L-like 22-130 1.2e-10 33.8 In-house 10-121 (305) alignment 
Range on Protein: 22-130
Range on HMM: 10-121/305.0
TVAASQGGRRYMEDRCVIHTERINNGLLdwTFVGVFDGHGGEHASEYVRRHLlMNIT----KNQK-----FESNSDEDILEAIRQGFLMTHEQMRHvyde
 . .|.. |.| |||        ..  |   . ||||||.|. |.|||...| ..|     |  |        |.|.  ||||....| | . .      
elyvsansrkyqedrnkvkislessqel..slfGvfdGhnGdiaaeyvkkkl.veivnkyvkenkvGysaknlnvddlpleaiksaslstdkssld....

wpyTASGYPSTAGTTV----SC
    |..    ||||.    . 
...saesdnkkaGttlngssas
PPM_PTC7_SpoIIE 23-294 2.5e-21 69.5 In-house 5-210 (230) alignment 
Range on Protein: 23-294
Range on HMM: 5-210/230.0
VAASQGGRRYMEDRCVIHT-ERINNGLLDWTFVGVFDGHGGEHasEYVRRHLLmNITKNQKFESNSdeDILEAIRQGFLMTHEQMRHVydewpytasgyP
. | || |. |||....    . ..|   . .||..|||||     .....|  .. ....|.. .  .  |..| ..|  . ....            |
asaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllr.talrelafagle..kpeeilrrlnlalaadlede...........p

STAGTTVSCVFIRNGK--LYTGHVGDSAIFLGTVeNGElhsrplttdhkpesvhEQLRIaKAGGETAvK-SGVTRVVWKrpqkmsqfmmmtsnsneqkhh
|. |.|.... |.. .  ||. ..||| ..| .  .|                 |  || .|||       . .||...                     
sssgaTavvalidpstgklyvanaGdsppllvrd.dgg................ereri.vagglps.lGilpgrvfgv.....................

qnpqimenipfLSVARSLGDLWSYNektNMFIVSPEPDlGVHRLT-GNDFCLVLASDGMTNVMTGDQAISIVFKEEE
           |.|... |||. .      ..|..|||  .. .. |.|  |.||||| ..|.. ......| .|.|
...........lavslapGdlllly...tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdele
subfamily_TAB1_pd Subfamily TAB1 32-105 9.4e-06 17.6 In-house 13-81 (333) alignment 
Range on Protein: 32-105
Range on HMM: 13-81/333.0
YMEDRCVIHteRINNGLLdwtFVGVFDGHGGEHASEYVRRHLLMNITKNQKFESNSDEDILEAIRQGFLMTHEQ
..||.. .   ...|. .     .||||. |..|...|  .|  .. ..|  .. ..... | ... |  . ..
evedkvflf..ktendpi...lyavFdGydGnkaakfveqrLvaellleqltdelaeaevkevlkrafeeverk
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 51-294 3.2e-19 62.5 In-house 20-275 (292) alignment 
Range on Protein: 51-294
Range on HMM: 20-275/292.0
WTF-VGVFDGHG--GEHASEYVRRHLLMNITKNQKFEsnsdEDILEAIRQGFLMTHEQMRHVYDEwpytasgYPSTAGTTVSCVFIRNG-KLYTGHVGDS
 ||   |.||||  |.. ...   .| .....  .       .. ||. .. | .  ...... .           |.|.| |  .|.. .|.  .||||
ltflaavldGhGvnGdkvaqlaedtlevelleltrql....qelsealllrildiaakldkltid.......aresattavvcarvrddralilanvGds

AIFLGT-VENGELHSRPLTTDHKPESVHEQLRIAKAGGETA---VK----SGVTRvVWKRPQKMSQFMMMTSnsNEQKHHQNPQIMENiPFL--SVA-RS
   ||  .   . . .||. |||||   |. || .|||      |.     | .| ||.| |.  .. .  .    . |  .  .. . | |    . . 
rallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtar.vwrrrqqeGdlalsra..lGdfhlfeaGvvae.Pelqihagrqy

LG---DLWSYNEKTNM----FIVSPEPDLGVH-----RLTGNDFCLVLASDGMTNVMTGDQAISIVFKEEE
||    ||. .  .      . .. .  ||.       |  .|  |||||||. .|..  . . .. | .|
lgrgpglwtrssiarhiayqhpltsdvplgldrklekeldsddaflvlasdGvldvllnaevvlllaksqe
subfamily_PDP_pd Subfamily PDP 51-81 6e-06 18.6 In-house 25-55 (398) alignment 
Range on Protein: 51-81
Range on HMM: 25-55/398.0
WTFVGVFDGHGGEHASEYVRRHLLMNITKNQ
 ...|||||||| ...| |...||  .... 
gvlfgvfDGHggaacaeavskrLlkyvaasl
PP2C_SIG_SM00331 52-329 1.7e-07 24.0 In-house 31-213 (217) alignment 
Range on Protein: 52-329
Range on HMM: 31-213/217.0
TFVGVFDGHGGEHASEYVRRHL---LMNITKNQKFESNSDEDILEAIRQGflmtheqmrhvydewpytaSGYPSTAGTTVSCVF-IRNGKLYTGHVGDSA
... |.||.|. .|.. . . |   |... ....  |.  . . .||..                    ..  .   | . ... ...|||.  ..||| 
lllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee...................keekgmfaTlllalydfssgklsyanaGdsr

IFLGTveNGELHSRPLTtdhkpesvheqlriakaggetavksgvtrvvwkrpqkmsqfmmmtsnsneqkhhqnpqimenipflsvarslgdlwsynekTN
..| .  .|.|  .                                                                                    ..
pyllr..dgklveilkd.................................................................................ve

MFIVS--PEPDLGVHRLTGN-DFCLVLASDGMTNVMTGDQaisivFKEEEMVEIHEEI--------NRNHSRCVLRSALQKWRslrADNVTIA
 ....  ||... .. |. . .  |.|..||.|.... ..     |.||.. || |.         ...  ...|..| ..      |..|. 
gaplGlepevsvdirelelekgdllllytDGltearsekg.....faeerleeiledlvdseaqelaqkiveellelakgsng...eDdiTvv
subfamily_KAPP-like_pd Subfamily KAPP-like 52-193 6.6e-06 18.3 In-house 35-167 (266) alignment 
Range on Protein: 52-193
Range on HMM: 35-167/266.0
TFVGVFDGHGGEHASEYVRRhLLMNITkNQKFESNSDEDILEAIRQGFLMTHEQMRHVYDEWpytaSGYPSTAGTTVSCVFIRNGK---LYTGHVGDSAI
.. .||||| |  |..  .. |. ..  ... .|  ..|  . | .   . .. ...|  .     . .     |.  ..  ..|.   | .. ||||. 
alfavfdGhaGkGaadaakk.lfpkel.ekllkstkqddGGdniydqskllenafkevdakl....kdfeyeGatatlalvwsdGqqrylqvanvGdssa

FLGTvENGelhSRPLTTDHKPESVHEQLRIAKAGgeTAVKSGVTR
||    |    |  |. ||| .  .|. || . |   ..  . ||
flsr.Gne...slelskdhkakdpeekqrikddG..itlsdnqtr
PP2C_2 Protein phosphatase 2C 55-284 1.7e-08 27.0 Pfam-A 28-185 (212) alignment 
Range on Protein: 55-284
Range on HMM: 28-185/212.0
GVFDGHGGE----HASEYVRRHLLMNITKNQKFESNS-DEDILEAIRQGFLMTHE--QMRHVYdewpytaSGYPSTAGTTVSCVFIRNGKLYTGHVGDSA
 | ||.|      ...... . ..  ..|. . || . .|..|..|... | . .  | ..            ..  .||.....|..|... ...||.|
aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq.......qeelkdyatTlllavitpgeivffqiGDga

IFLGTvENGELHSrpLTTDHKPESVHEQLRIAKAGGETAVksgvtrvvwkrpqkmsqfmmmtsnsneqkhhqnpqimenipflsvarslgdlwsynektn
|..   ..||...  |..... | . |  .. ..  |  .                                                            
ivvrd.rdgevql..lgepdsgeyanettfltsedaeeel............................................................

mfivspepdlGVHRLTGN-DFCLVLASDGMTNVMTGDQ
           . ||. .   .|.| .||. . .. ..
..........rirrlklepgdalllmTDGvsdslrkee
PP2C_2 Protein phosphatase 2C 55-284 1.7e-08 27.0 In-house 28-185 (212) alignment 
Range on Protein: 55-284
Range on HMM: 28-185/212.0
GVFDGHGGE----HASEYVRRHLLMNITKNQKFESNS-DEDILEAIRQGFLMTHE--QMRHVYdewpytaSGYPSTAGTTVSCVFIRNGKLYTGHVGDSA
 | ||.|      ...... . ..  ..|. . || . .|..|..|... | . .  | ..            ..  .||.....|..|... ...||.|
aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq.......qeelkdyatTlllavitpgeivffqiGDga

IFLGTvENGELHSrpLTTDHKPESVHEQLRIAKAGGETAVksgvtrvvwkrpqkmsqfmmmtsnsneqkhhqnpqimenipflsvarslgdlwsynektn
|..   ..||...  |..... | . |  .. ..  |  .                                                            
ivvrd.rdgevql..lgepdsgeyanettfltsedaeeel............................................................

mfivspepdlGVHRLTGN-DFCLVLASDGMTNVMTGDQ
           . ||. .   .|.| .||. . .. ..
..........rirrlklepgdalllmTDGvsdslrkee
subfamily_PDP_pd Subfamily PDP 89-181 4.5e-06 19.0 In-house 113-210 (398) alignment 
Range on Protein: 89-181
Range on HMM: 113-210/398.0
EDILEAIRQGFLMTHEQM-----RHVyDEWPYTASGYPSTAGTTVSCVFIRNGKLYTGHVGDSAIFLGTVE-NGELHSRPLTTDHKPESVHEQLRIAKA
|.. ||....||   ...     ... .|   . .  ....|..  ...|.. .|.   .||..  ||..| .|. ....|..|.  .. .|  || |.
ekvkealkkaFlklDkdistealkkl.kekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikke
subfamily_PPM1G_pd Subfamily PPM1G 123-186 1.8e-07 23.5 In-house 295-354 (473) alignment 
Range on Protein: 123-186
Range on HMM: 295-354/473.0
TAGTTVSCVFIRNGKLYTGHVGDSAIFLGtvENGElhSRPLTTDHKPESVHEQLRIAKAGGETA
 .|||   . ... ||.   .|||   |   .||.     | .|||||  .|. || ||||.  
dsGttAvvaLlkekklivAnaGDsRcvls..rnGk..AldlslDHkPeDevEleRiekAGGkvd
subfamily_KAPP-like_pd Subfamily KAPP-like 227-331 2e-07 23.3 In-house 168-264 (266) alignment 
Range on Protein: 227-331
Range on HMM: 168-264/266.0
IPFLSVARSLGDLWSynEKTNMFIVSpEPDLG-VHRLTGNDFCLVLASDGMTNVMTGDQAISIVFKEEEmveiHEEINRNHSRCVLRSALQKwrSLRADN
|  | |.|.||| .    . |. ..| || .     ||  |  |..||||. .|..|..|| .|    .    ... . . . ..|..|.|   ..  ||
inGlavsralGdhfi..kelniGlis.epyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslyd....qqatedkmasslletaiqs..ikakdn

VTIATV
|..  |
vsvivv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 228-331 2e-07 23.1 In-house 179-274 (276) alignment 
Range on Protein: 228-331
Range on HMM: 179-274/276.0
PFLSVARSLGDLWSynEKTNMFIVSpEPDLG-VHRLTGNDFCLVLASDGMTNVMTGDQAISIVFKEEEmveiHEEINRNHSRCVLRSALQKwrSLRADNV
  | |.|.||| .    . |. ..| || .     ||  |  |..||||. .|..|..|| .|    .    ... . . . ..|..|.|   ..  |||
nGlavsralGdhfi..kelniGlis.epyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslyd....qqatedkmasslletaiqs..ikakdnv

TIATV
..  |
svivv
subfamily_PPM1E_pd Subfamily PPM1E 230-334 2.1e-08 26.7 In-house 171-263 (265) alignment 
Range on Protein: 230-334
Range on HMM: 171-263/265.0
LSVARSLGDlwsYNEKTnmfIVSPEPDLGVHRLTGNDFCLVLASDGMTNVMTGDQAISIVfkeEEMVEIHEEINRNHSRCVLRSALQKWRslrADNVTIA
|||.|..||   ...|     || |.|.   .|.|.. .|.||.||. .|.. ......|   ||... ..| . . .. .. .| ..     .||.|. 
LsvsRaiGD...vklkp...yvsgeadvaeveldgseeylilacDGlwDvvneeevvklv...eefladgaedlsevakllveaakeags...sDnitvv

TVIFD
 |..|
vvfld
subfamily_ILKAP_pd Subfamily ILKAP 230-308 4.8e-06 18.9 In-house 185-262 (293) alignment 
Range on Protein: 230-308
Range on HMM: 185-262/293.0
LSVARSLGDLwSYNEktnmFIVSPEPDLGVHRLTGNDFCLVLASDGMTNVMTGDQAISIVFKEEE----MVEIHEEINRNHSR
| |.||.||   . .      |.  ||.   .|| ||  .||| ||. .|.. |.... . |  |      .|.|| . ... 
levsrsiGdg.rfkr....lGvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskee
subfamily_PPM1G_pd Subfamily PPM1G 230-290 5e-06 18.8 In-house 363-426 (473) alignment 
Range on Protein: 230-290
Range on HMM: 363-426/473.0
LSVARSLGDlWSYNEKTNM----FIVSPEPDLGVHRLTGNDFCLVLASDGMTNVMTGDQAISIVF
| ..| ||| ..| .....     ..|  ||. |. || .|  ||||.||. |||. .. .  | 
LnlsRAlGD.haYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvr
subfamily_PDP_pd Subfamily PDP 252-312 6.4e-06 18.5 In-house 271-331 (398) alignment 
Range on Protein: 252-312
Range on HMM: 271-331/398.0
SPEPDLGVHRLTGNDFCLVLASDGMTNVMTGDQAISIVFKEEEMVEIHEEINRNHSRCVLR
. ||..  |.|. ||  ||||.||. .... ....|.| .  .  . .|... ...   |.
taePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlk