Gene Y69E1A.4 in Caenorhabditis elegans

Synonym: CELE_Y69E1A.4, Y69E1A.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP227_AA protein Get Run
CeleP227_AA_11-363 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP5C_pd Subfamily PPP5C 7-91 9.8e-06 17.8 In-house 12-93 (322) alignment 
Range on Protein: 7-91
Range on HMM: 12-93/322.0
EDQKNVRNFVNKILEKIVFKWTHKTSMDLFCAAELAELCHRARELIwsePIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSS
|..|  ..||...||..  . . .. . |   .|  || ..   |.    | .. .  . | ||||||| ||| ....|| | ..
eeekitkefvkellelfkkqkklhkkyalkilleakellkklpslv...eitieetkkltvcGdihgqfydllnifelnGlpsee
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 17-99 5.1e-13 41.7 In-house 4-86 (298) alignment 
Range on Protein: 17-99
Range on HMM: 4-86/298.0
NKILEKIV-FKWTHKTSMDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSsQEFEALKD
...| ...    ..|. .     ... .|.. |.... . . .....||| | ||||||. ||| ..| .|.| . ...  | |
dellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppd.anylflGd
0049330 Metallo-dependent phosphatases 25-361 3.6e-96 314.9 In-house 19-301 (309) alignment 
Range on Protein: 25-361
Range on HMM: 19-301/309.0
FKWTHKTSMDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPlssqefealkdttvrsretgkrpqsephstqpessn
. . . . . |.   || .|...|.|...|||..|.|...| | ||||||.||||..|...|.|                                    
llielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfp....................................

dvkppvaapksvnkevttGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAV
                  .  |..||||.|||||.| ||. || ||||.|||...|||||||.| .|  |||..|. ..|.|.|.| |..... .|..||
..................pedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaav

INNTIMCMHGGISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLV
|...|.|.|||.| .|.. .|.. ..||||||. |.|.||.|.||.|. .|. |. ||...|||. |.. ||||..|...||||..|..||..| ...|.
iggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgkli

TIFSAPNYCGQNDNTAAVFSIDKKLKISINVFRPESR
|.||||||||...| .||  ||..|.||. .|.| ..
tvfsapnycgrlgnlgavleidedlvisfllfepvpl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 26-364 3.4e-251 824.9 In-house 1-339 (339) alignment 
Range on Protein: 26-364
Range on HMM: 1-339/339.0
KWTHKTSMDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQEFEALKDTTVRSRETGKRPQSEPHSTQPESSND
|||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||
kwthktsldlfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwplssqefealkditvrsretgkrpqsephstqpessnd

VKPPVAAPKSVNKEVTTGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVI
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
vkppvaapksvnkevttgykrylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavi

NNTIMCMHGGISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVT
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
nntimcmhggisehltsfnqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvt

IFSAPNYCGQNDNTAAVFSIDKKLKISINVFRPESRDKK
|||||||||||||||||||||||||||||||||||||||
ifsapnycgqndntaavfsidkklkisinvfrpesrdkk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 29-361 6.7e-184 603.3 In-house 2-317 (317) alignment 
Range on Protein: 29-361
Range on HMM: 2-317/317.0
HKTSMDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQEfealkdttvrsretgkrPQSEPHSTQPESSNDVKP
.|...|||...||.|||.|||||.|.||..|.||||....|||||||.||||.||.|||||||||                 ..|||.|...|||.|||.
pkkcqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwplssqe.................eksepkslllesskdvkq

PVAAPKSVNKEVTTGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNT
.|||.||||||||.|||.||||||||||||||.||||||.||||.|||...|||||||||.|||.|||||||..||.|.|||.||..|||.|.|||.|..
tvaavksvnkevtkgykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkk

IMCMHGGISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFS
|.||||||||.|....|....||||.|||||||.||||||||...||||.|||||..|||..|...|||||||..|.|.|||||||||||..|.||||||
ilcmhGGiseelldlkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifs

APNYCGQNDNTAAVFSIDKKLKISINVFRPESR
||.||||.||.|||.|.||||||||||.|||||
apsycGqldniaavlsvdkklkisinvlrpesr
0045823 Metallo-dependent phosphatases 30-363 1.2e-100 330.4 In-house 37-328 (473) alignment 
Range on Protein: 30-363
Range on HMM: 37-328/473.0
KTSMDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGwplssqefealkdttvrsretgkrpqsephstqpesS---Ndv
 . . |. . .| .|...|.|....|| .|.|...| | ||||||.||||..|...|                                        .  
lkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekig....................................fpped..

kppvaapksvnkevttgykRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVIN
                   |..||||.|||||.| ||. || |||..||....|||||||.| .|. |||..|. ..|...||| |.. ..  |..|||.
...................rlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaavig

NTIMCMHGGISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPdPTEKG--------YKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFF
..| ..|||.| .|.. .|    .||||||| |.|.|| |.||  ...|        . .| |||...|||.|.. |||| .|....|||..|..|||..
gkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyell

DGRR------LVTIFSAPNYCGQNDNTAAVFSIDKKLkISINVFRPESRDK
 ...      ..|.||||||||...| |||  ||..| ||. .|.| . ..
fdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpl
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 31-92 4.4e-10 32.1 In-house 11-72 (290) alignment 
Range on Protein: 31-92
Range on HMM: 11-72/290.0
TSMDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQ
  .| |   .. |. ....|..   | .|..|||| ..||||||.|.|| ..|  | |   .
gvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvk
0053225 Metallo-dependent phosphatases 32-358 7.5e-88 287.7 In-house 18-290 (293) alignment 
Range on Protein: 32-358
Range on HMM: 18-290/293.0
SMDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPlssqefealkdttvrsretgkrpqsephstqpessndvkppva
 . |. . || .|.. |.|....||..|.|...| | |||||..|||||.|.. |.|                                           
llkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfp...........................................

apksvnkevttGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRY-DAQLYECFQNMFNVFPFCAVINNTIM
           .. |..||||.|||||.|.||. || |||| |||...|||||||.. .|  |||..|. ..| .|.|.. ... .. .|..|.|...|.
...........pedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkil

CMHGGISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDpTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAP
..|||.| .|....|    .|||.||. |.|.|| | |||   .|. || ||...|||. |.. |||| .|...||||||| |||... ...|||.||||
fvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsap

NYCGQNDNTAAVFSIDKKLKISINVFRP
||.|...| .||  .|..|.... .|.|
nylgrlgnlgavlaldeglvwgfklfap
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 32-92 3.1e-10 32.5 In-house 6-66 (287) alignment 
Range on Protein: 32-92
Range on HMM: 6-66/287.0
SMDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQ
 .| |   .. |. ....|..   | .|..|||| ..||||||.|||| ...  | .   |
vldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvq
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 33-359 4.5e-121 396.7 In-house 5-283 (284) alignment 
Range on Protein: 33-359
Range on HMM: 5-283/284.0
MDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQEFEAlkdttvrsretgkrpqsephstqpessndvkppvaa
 .|.   || |||.|||||.| |.. |..|||. ..|||||||.||||.||.|||| ...| .                                     
qkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeake....................................

pksvnkevttgyKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCM
            |.||||||||||||||.||. || |.|| .||...||||||||| ||  |||| | . ||  .|||.||  ||..|.|||... |.||
............kkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicm

HGGISEHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNY
||||||.| ...|.  ..||..|||.||..|||||||. . .||| | |||  |||. |.. |||| .|..|.| |||| ||||||  |.|||||||| |
hggisedlldlkqldklerpidipdigviadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsy

CGQNDNTAAVFSIDKKLKISINVFRPE
||| || |||...|..| .|..|..|.
cgqldniaavlnvdeelvasftvlkpd
subfamily_PPP4C_pd Subfamily PPP4C 33-86 1e-10 34.3 In-house 13-66 (288) alignment 
Range on Protein: 33-86
Range on HMM: 13-66/288.0
MDLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNG
..| .  |. .||..|||..  |    ....|. | ||||||| ||| .....|
celikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvgg
subfamily_PPG1_pd Subfamily PPG1 34-86 3.8e-08 25.9 In-house 12-64 (300) alignment 
Range on Protein: 34-86
Range on HMM: 12-64/300.0
DLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNG
.|.  . . ||... .||. .|    ....|. |.||.|||| |.| .... |
ellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkigg
subfamily_PPP6C_pd Subfamily PPP6C 34-86 7.9e-08 24.8 In-house 13-65 (290) alignment 
Range on Protein: 34-86
Range on HMM: 13-65/290.0
DLFCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNG
. .  ..| .||..  .|.  |     ...|. | ||||||| ||. ..   |
kylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtgg
subfamily_PPZ_pd Subfamily PPZ 36-92 3.1e-11 36.3 In-house 25-81 (300) alignment 
Range on Protein: 36-92
Range on HMM: 25-81/300.0
FCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQ
.  .|. ..|..||||. ..| .|.|  .. ..||.|||. ||| ..   |.| |..
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsan
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 36-84 1.5e-07 23.9 In-house 7-55 (302) alignment 
Range on Protein: 36-84
Range on HMM: 7-55/302.0
FCAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDM
.   ||  |..   ||.  |  . .. .|. ..|||||||.||. .| .
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilna
subfamily_PPP1C_pd Subfamily PPP1C 37-91 1.5e-14 46.9 In-house 11-65 (282) alignment 
Range on Protein: 37-91
Range on HMM: 11-65/282.0
CAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSS
  ||. .|...|||.. |.||.|.||||. ..||||||. ||| .....| | .|
keaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpes
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 37-84 1.6e-07 23.8 In-house 7-54 (302) alignment 
Range on Protein: 37-84
Range on HMM: 7-54/302.0
CAAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDM
   ||  |..   ||.  |  . .. .|. ..|||||||.||. .| .
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilna
PP2Ac_SM00156 38-359 2.2e-106 347.9 In-house 3-270 (271) alignment 
Range on Protein: 38-359
Range on HMM: 3-270/271.0
AAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLdmngwplssqefealkdttvrsretgkrpqsephstqpessndvkppvaapksvN
. |..||.....|.. .|. .....||..|.||||||.|||| .|                                                      .
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll......................................................e

KEVTTGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGIS
.  .. ...|.||||||||||.|.||..||.|||..||....||||||||.|||. |||..||...|....||.|...|...|..|.....|.|||||.|
lageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGls

EHLTSFNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQND
..|.|..... .||. |.|. |.|.||.|.||. .|||..||.||.|.|||. |.. ||||..|...||.|.||..|||||  ..|||||||||||....
peleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefs

NTAAVFSIDKKLKISINVFRPE
|.|||....|.||.||......
nkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 38-105 4.3e-12 38.9 In-house 26-92 (299) alignment 
Range on Protein: 38-105
Range on HMM: 26-92/299.0
AAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSqEFEALKDTTVRSR
  || .||. |.. . |.. .|..|||| | ||||||. ||| ..|..|.|  . .|  | |   | |
eqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdv.nflflgdyvdrgr
subfamily_PPP2C_pd Subfamily PPP2C 38-86 7.5e-09 28.2 In-house 19-67 (290) alignment 
Range on Protein: 38-86
Range on HMM: 19-67/290.0
AAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNG
 .|..|||..|.|.. .|    ....|. |.||.|||| ||| .. . |
esevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkigg
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 38-87 1.8e-06 20.4 In-house 10-59 (281) alignment 
Range on Protein: 38-87
Range on HMM: 10-59/281.0
AAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGW
  |. .. . .. .. .|  . ....|| |.||.|.||.|| ..... | 
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgr
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 38-88 2.1e-06 20.1 In-house 22-72 (307) alignment 
Range on Protein: 38-88
Range on HMM: 22-72/307.0
AAELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWP
  |. .. . |. .. ||  .. .. |  |.||.||||.||. |. . | |
keefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrp
PPP_3 39-91 7.5e-12 37.8 In-house 5-56 (271) alignment 
Range on Protein: 39-91
Range on HMM: 5-56/271.0
AELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLlAMLDMNGWPLSS
 ||.||.....|.. .|.. ....||. |.||||||.|||   |  || | ..
nelkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspe
PPP_1 39-86 8.3e-11 34.6 In-house 4-51 (264) alignment 
Range on Protein: 39-86
Range on HMM: 4-51/264.0
AELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNG
.|||||.....||. .|.. |.....| | ||||||||||| .  . |
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvgg
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 39-99 4.1e-07 22.4 In-house 9-68 (280) alignment 
Range on Protein: 39-99
Range on HMM: 9-68/280.0
AELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSsQEFEALKD
|.. .. .. ....  .  .....||. | ||.|||. ||| ...  ..|   |..  | |
adidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppd.qnylflgd
subfamily_PPP3C_pd Subfamily PPP3C 40-353 4.1e-73 239.7 In-house 45-316 (452) alignment 
Range on Protein: 40-353
Range on HMM: 45-316/452.0
ELAELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGwplssqefealkdttvrsretgkrpqsephstqpessndvkppvaapksvnke
. ... ..| .|. .|. .|..|||| |.||||||| ||| .....|                                                     
aalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgG.....................................................

vTTGYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEH
      .||||||||||| ||.|.|. | |||.|||....|||||||.| .   . | .|....|. ..|. . . |...|. |..|.  .|.|||.| .
.dPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspe

LTSFNQFSVFKRPLEIPDVGVLTDLTWADPDP------TEKGYKP-SARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDG------RRLVTI
..|...   ..|  |.|  | | || |.||        ||. ..| |.|| |....  |   ||.| ||  .|| |.. ..||. .          |.|.
ikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitl

FSAPNYCGQNDNTAAVFSIDKKlKISI
||||||..  .| |||. .... .. |
fsapnyldvynnkaavlkyenn.vmni
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 42-92 1.8e-08 27.0 In-house 29-79 (297) alignment 
Range on Protein: 42-92
Range on HMM: 29-79/297.0
AELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSSQ
 .|   | ... ..  .....||| | ||||||| ||| ..   ||| ...
lklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptan
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 43-91 4.2e-09 29.2 In-house 10-58 (284) alignment 
Range on Protein: 43-91
Range on HMM: 10-58/284.0
ELCHRARELIWSEPIFLKLEAPICVMGDIHGQFDDLLAMLDMNGWPLSS
 |  .| ...  .|.... ..|| . ||||||| ||| ..| ||.|  .
tllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphra
Metallophos Calcineurin-like phosphoesterase 64-310 2e-35 115.9 Pfam-A 2-198 (200) alignment 
Range on Protein: 64-310
Range on HMM: 2-198/200.0
PICVMGDIHGQFDDLLamldmngwplssqefealkdttvrsretgkrpqsephstqpessndvkpPvAAPKSVNKEVTTGYKRYLFLGDYVDRGPFSMEV
.| |.||.||..|||                                                    .. .  .. .  .   .|||||.||||. | |.
rilvigDlHgglddle.................................................d.lllillkiaaeekpdlvlflGDlvdrgdwsset

VILL--TALKLAYPDRIYLLRGNHESRSVNTSYGFYREVN----------------------------------YRYDAQLYECFQNMFNVFPFCAVINN
  ||   .|||..|....||||||||...|. |||. |..                                  ....   .| ... |.  | .| ...
lalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdg

TIMCMHGGISEHLTSFNQFsvfkrpleipdvgvltdltwadpdptekgykpsargASFVFGPPALRAFLKKLDLQMVIRGHQV
.| ..||..|... | ..                                     .|. |||.||. .|.| ....|.|||. 
killtHgplsssggsgddi....................................gselfgpdalekllekygvdlvlrGHtH
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 66-347 1.8e-06 20.1 Pfam-A 4-155 (156) alignment 
Range on Protein: 66-347
Range on HMM: 4-155/156.0
CVMGDIHGQFDDLLamldmngwplssqefealkdttvrsretgkrpqsephstqpessndvkppvaapkSVNKEVtTGYKRYLFLGDYVDrgpfSMEVVI
....|.||..|.|                                                         | ...  ... .|..||.|.    ..||| 
aiiSDlHgnldale.......................................................avledi.kevdlilhaGDlve....peevve

LLTALklaypdRIYLLRGNHESRSVNTSYGFYRevnyrydaqlyecfqnmF--------NvfpfcaviNNTIMCMHGGISEhltsfnqfsvfkrpleipd
|| ..      ... .||||.   ..... .                   .        .        ..... .||                       
lledi......pvlavrGnhDeaelpkelavel.................llaaaaleie........gdrvllvhgtpls...................

vgvltdltwadpdptekgykpsargasFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEfFDGRRLVTIFSAPNYCGQNDNTAAVFSIDK
                           . ... .|.. ||. . ..|. ||  .    .  .|...|.  |. .  .... | |.. ...
...........................vqsseeelaellkeagadlvflGHtHkpkvek.rggtlvvnpGsvgepregdeatyalldved
PPP_2 143-310 3.3e-57 186.4 In-house 25-197 (198) alignment 
Range on Protein: 143-310
Range on HMM: 25-197/198.0
GYKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVN-YRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLT
  ..||||||||||| .|.||..||.|||| ||....||||||||..||. |||..||   ......|. .|..|...| .|.|.......|||.||...
perkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfelLplaalidekvlvvHGGlseeik

SFNQFSVFKRPLEIPDVGVLTDLT----WADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQV
...| .  .|. |.|. | |.||.    . ||. .|.....|||||...||| . . .|.| .|...|| |.|
lldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_PPP1C_pd Subfamily PPP1C 144-360 7.7e-92 300.5 In-house 64-280 (282) alignment 
Range on Protein: 144-360
Range on HMM: 64-280/282.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
 ..||||||||||| .|.|...|| |.|. ||....|||||||| |.|. |||| |.. ||...|...|...||..|..|.... |.|.|||.|..|.|.
esnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
.| .  .||||.|. |.|.|| |.||| . .|.. ..|| ||.||. ....||.| ||....|.|||||||||||  |.|||.||||||||. ||..||.
eqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavl

SIDKKLKISINVFRPES
|.|..|..| ....|..
svdeellvsfqilkpak
PPP_3 144-357 4.7e-79 258.2 In-house 56-270 (271) alignment 
Range on Protein: 144-357
Range on HMM: 56-270/271.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVN-YRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTS
 ..||||||||||| .|.||..|| |||. ||....|||||||||..|. |||..||   ......|. .|..|...| .|.|.......|||.|....|
etkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiks

FNQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAV
..| .  .|. |.|. | |.||.. ... .|.|...|.|||...||| . . ||.| .|...|| |...|.|||..  ...||.|||||||....|..|.
ldqikklerkievpeegklldlllssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagai

FSIDKKLKISINVFR
......|. ......
lkleealtsefkqle
subfamily_PPP4C_pd Subfamily PPP4C 144-358 7.5e-67 218.5 In-house 70-284 (288) alignment 
Range on Protein: 144-358
Range on HMM: 70-284/288.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYD-AQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTS
 ..||||||.|||| .|.|  .|| |||. |||||.|.|||||||..  .|||| |.  .|  |....   ..|. ....|.|.. |.|.|||.| ....
etnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsist

FNQFSVFKRPLEIPDVGVLTDLTWADPDPTEkGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAV
...  .  |  |.|. |.|.|| |.||. .| |.  | ||| ..||  .   | .. |.....| ||.| .|| .   ....|..|||||| .  | ||.
ldeirsidrkqevphegplcdllwsdpedae.gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaai

FSIDKKLKISINVFRP
. .|..|.   ..|  
leldeeldkdfkifea
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 144-358 1.2e-58 191.7 In-house 71-299 (302) alignment 
Range on Protein: 144-358
Range on HMM: 71-299/302.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYD----AQLYECFQNMFNVFPFCAVINNTIMCMHGGISEH
 ....|||||||||. |.| . |. |||. || .  |||||||....| .|||  |.. |.      ...| |...|  .|. |.. . |.|.|||||..
sdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk

LTSFNQFSVFKRPL-EIPDVGVLTDLTWADPDPTE---------KGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSA
|.|... .  |||| |. .  . .|| .|||  ..         |  |   || |.||   |.| . |.|.|....|.||..  |. ||  ..|.|||||
lesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsa

PNYCGQNDNTAAVFSIDKKLKISINVFRP
|.|  . ||. ||. .| . |.|| |.|.
prymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 144-358 2.2e-58 190.8 In-house 72-300 (302) alignment 
Range on Protein: 144-358
Range on HMM: 72-300/302.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYD----AQLYECFQNMFNVFPFCAVINNTIMCMHGGISEH
 ....|||||||||. |.| . |. |||. || .  |||||||....| .|||  |.. |.      ...| |...|  .|. |.. . |.|.|||||..
sdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk

LTSFNQFSVFKRPL-EIPDVGVLTDLTWADPDPTE---------KGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSA
|.|... .  |||| |. .  . .|| .|||  ..         |  |   || |.||   |.| . |.|.|....|.||..  |. ||  ..|.|||||
lesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsa

PNYCGQNDNTAAVFSIDKKLKISINVFRP
|.|  . ||. ||. .| . |.|| |.|.
prymnesdnkGavlkvdtngklsisvlrn
PPP_4 144-310 2.7e-55 180.5 In-house 28-196 (197) alignment 
Range on Protein: 144-310
Range on HMM: 28-196/197.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
 ..|.|||||||||..|.||..||.|||| ||....||||||||.|.|  |||..||  .. ..... .|..|.. | .|.|.......|||.|..|.| 
ersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfdllplaalidekvlvvhgglsdelesl

NQFSVFKRPLEIP-DVGVLTDLT-WADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQV
..    .|. |.| . ... ||  |.|| ....|...|.|||...||| . . ||.| .|...||.|..
dkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 144-311 2.2e-52 171.0 In-house 28-199 (199) alignment 
Range on Protein: 144-311
Range on HMM: 28-199/199.0
YKRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYR-YDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTS
 ..|.|||||||||..|.||..||.|||| ||....|||||||....|  |||. ||  . . ...|. ....|.. | .|.|.......|||.|... |
erlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvfdwlPlaalidekvlvvhgglspeiks

FNQFSVFKRPLEIP-DVGVLTDLT-WADPDPTEKG-YKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVV
 ..    .|. ||| . |.  ||. |.|| .. .|   .| |||...||| . . ||.| .|...||.|...
iellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 145-361 3e-90 295.2 In-house 79-296 (298) alignment 
Range on Protein: 145-361
Range on HMM: 79-296/298.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRY-DAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
. ||||||||||| ...||..|| | |. ||....|||||||  ..|  |||| |.. || . .||. ||..||..|..|.| . |.|||||.|..|.|.
anylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
.|.  .||| . ..  . .|| ||||. . ||.....||.|.|||  ... .|.|||. .|.|.|||| |||||| ...||||||||.|||| ||.||| 
dqlrelkrpfdskeeslaidllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavm

SIDKKLKISINVFRPESR
..|.||..| .|..||..
kvdeklvvsfevlkpekk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 145-362 5.5e-83 271.3 In-house 61-278 (280) alignment 
Range on Protein: 145-362
Range on HMM: 61-278/280.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
. ||||||||||| . .||..|| | |. ||.....||||||  |.|  |||. ||  ||. .||. ||.... .|..|...  |.|||||.|..| |..
qnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvsld

QFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFS
... ..||.. .|  . .|| ||||.    |.  ..||.| .||   .. . .|||.....||||||.|||||| ...|||.||||.|.|. ||.|||  
dlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavli

IDKKLKISINVFRPESRD
.|..|..|..|..|. |.
vderlivsfevlkpalre
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 145-361 1.9e-77 253.3 In-house 63-279 (281) alignment 
Range on Protein: 145-361
Range on HMM: 63-279/281.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
....|||||||||| |.||.||| .||..|.|||.|||||||  |||  |||| |  ..|  .|.  ||. || .|. | |.. ..|||||.|  ||. .
evlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltald

QFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFS
.     .|.. .| |.. || |||||.  ...| |.||.||.||   .    |.|.....||.|||| |||| . ||.|.|.||.|||| .  |.|||  
elrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlk

IDKKLKISINVFRPESR
.|..|.||.  . |.| 
vdetlgislvalvpase
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 145-361 1.2e-76 250.4 In-house 65-284 (287) alignment 
Range on Protein: 145-361
Range on HMM: 65-284/287.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
 .|||||||||||. |.||..|| .||.||| ...||||||| . .|. |||. |.. ... .||. |...|. .|.|| ... |.|||||||..| |..
vqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksld

QFSVFKRPLEIPDV--GVLTDLTWADPDPTEKGYKPS-ARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAA
..  .|.|    .   |.  || ||||.   |....   |. | |||   .  .|||||.....| |.|.|.||.|.  .||||.|||| |.|.. |..|
slkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlga

VFSIDKKLKISINVFRPESR
|  ..| |..|. |..||  
vvvvskslelsfvvlkpedf
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 145-362 4.5e-76 249.0 In-house 79-297 (299) alignment 
Range on Protein: 145-362
Range on HMM: 79-297/299.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDA-QLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
  .||||||||||   .|...|| . |. ||.|...||||||  ..|  |||| |.| || . .|.  ||. |...|.. .|.. |.|||||.| .|...
vnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
.|.  . || . |.  .  || ||||| . |.... .|| |.|||.  ..  ...||...| | ||||.||||||  ..|||||||| |||| ||.||..
dqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaim

SIDKKLKISINVFRPESRD
 .|..|  .. |..| ...
kvdenlvctfvvlkptpks
PPP_1 145-344 4.2e-74 242.1 In-house 56-263 (264) alignment 
Range on Protein: 145-344
Range on HMM: 56-263/264.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVN-YRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
..||||||||||| .|.|...||.|||| ||....|||||||||.|.. |||. ||  ..|....|. ....|.|.| .|.|.. |...|||.|..|.. 
tnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldll

NQFSVFKRPLEIPDVGVLTDLT-------WADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQN
.|    .|  |.|. | |.||.       . |.. .|.. . | |||...||. . . ||.| .|...|| |.|.|.||||.  |..||||||.||. . 
dqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeeg

DNTAAVFS
.|..|. .
snrgayvk
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 145-363 4.6e-73 239.1 In-house 58-278 (284) alignment 
Range on Protein: 145-363
Range on HMM: 58-278/284.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDA-QLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
  |||||||||||   .| ..|| | |. .|.....||||||   .|  |||| |.. ||.   .|  |. .| |.|. |.. . |.|||||.|. |   
anylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnv

NQFSVFKRPLEIPDVGVL-TDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAV
 |.   |||.. |.   |  |. |.||   .||..| .|| |.|||  ||| .| .|....|.| ||||.||||||  |||||||||| |||| ||.|||
sqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaav

FSIDKKLKISINVFRPESRDK
. ..|.|  |. |.||  .  
myvnknlvcsfvvlrprkkia
subfamily_PPP5C_pd Subfamily PPP5C 145-356 3.5e-67 219.7 In-house 94-306 (322) alignment 
Range on Protein: 145-356
Range on HMM: 94-306/322.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGI-SEHLTSF
. ||| ||.|||| ||.||...| ..|| ||....| |||||| ..|  |||  ||...| ..... |...|| .|.. |||. .. .|||. ||.  ..
npylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTeKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
...   .|  . |. |.| .| |.||... .| .|| || .. |||   . |||. .|...|| |.| |.|||. .  .|.|.||||||| | .| .|. 
ddlrkidrnaqppeegllvellwsdpqea.nGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafi

SI-DKKLKISINVF
.. ...||. .. |
tlrgddlklkfktf
subfamily_PPZ_pd Subfamily PPZ 145-358 1.1e-64 211.8 In-house 80-293 (300) alignment 
Range on Protein: 145-358
Range on HMM: 80-293/300.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
  |||||||||||  |.| ..|| . |. ||. ..|||||||   |   |||| |.. | . .... | . || .|..|..   |.|.|||.|  | |..
anylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmd

QFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFS
.     || ..||.|.. || |.||  . . ..   || |...   |.  ||.|. ...| | | |||||||||. | |||.||||||||. ||  ||.|
eirhvvrptdvpdfglindllwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavms

IDKKLKISINVFRP
. . |  |.... |
vsegllcsfelldp
subfamily_PPP6C_pd Subfamily PPP6C 145-358 1.5e-62 204.4 In-house 70-283 (290) alignment 
Range on Protein: 145-358
Range on HMM: 70-283/290.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRY-DAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
..|.||||.|||| .|.| . .| .||. ||||| ||||||||| .   |||| |   .| .|. .  . ..|.... .|.|.. ..|.|||.| ... .
tsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTEKgYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
.| .| .|  |||  | ..|| |.||.  |. .. | ||| ..||    . |..  .|....| ||.||.|....   .|||..|||||| .  | |...
dqirvieraqeiphkgafcdlvwsdpedvet.wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasil

SIDKKLKISINVFRP
..... . . ..|. 
aledaeereaklfka
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 145-364 3.1e-60 197.1 In-house 35-261 (263) alignment 
Range on Protein: 145-364
Range on HMM: 35-261/263.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDA-QL----YECFQNMFNVFPFCAVINNTIMCMHGGISEH
 .||||||||||| .|.||..|| .|||| | ...||||||| ...|  |||. |.. |..  ..    |. |...|. .|.||.... |.||||||| |
tqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhfnqvfsymplcaivskrilcmhggisph

LTSFNQFSVFKRPLEIPDVGVL-TDLTWADPDPTEKGYKPS-ARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQND
| |...      |||      |  || ||||.   ||..|   |  | |||   .  . |.||.....| ||||| || ||  |||.|.|||  |  .  
lkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielc

NTAAVFSIDKKLKISINVFRPESRDKK
| |||  ..| |..|.  ..||  . .
nyaavvvvnkmlelsfvqlkpedfevr
subfamily_PPP7C_pd Subfamily PPP7C 145-243 3.4e-29 94.7 In-house 93-193 (383) alignment 
Range on Protein: 145-243
Range on HMM: 93-193/383.0
KRYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRY---DAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHlT
. |.| ||.||||  |.|....| || |.||  .|| |||||   .|  ||| .||. .|   .... . ....|  .|....|.. |. .|||||.. |
npyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.t

SF
..
dl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 146-358 2e-68 223.8 In-house 62-274 (280) alignment 
Range on Protein: 146-358
Range on HMM: 62-274/280.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFNQ
. .||||||||||  .||.||| .||. | |||||||||||. |||  |||| |..|.|   |.  ||. || .|....|.. ..|||||.|  |  .. 
klmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldt

FSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFSI
     || |  | |.| || |.||    .|.  | || |..||   .    | |.....||.||||.||||.. ||||.|.|| |||| |  |.|||  .
irniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvcl

DKKLKISINVFRP
. .|..|.. . |
nanlqvsfqqlip
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 146-360 1.7e-67 220.8 In-house 79-296 (297) alignment 
Range on Protein: 146-360
Range on HMM: 79-296/297.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDA-QLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
 ||||||||||| ||.| ..|| | |. .|  ..|||||||   ||  |||| |.. ||.. ..| .||..|| .|.. .| . |.|||||.|  ||   
nylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkef

---QFSVFKRPLEIpDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAA
    .  ..|. |    ....|| ||||     |.    |||   ||  |.     ...|..| | ||||.|||||| ||.|||||||| |||| || ||
tldtlrkiersteg.kerlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaa

VFSIDKKLKISINVFRPES
..| |.||. |....|| |
fmscdeklqcsfeilrpts
subfamily_PPP2C_pd Subfamily PPP2C 146-361 1.9e-67 220.5 In-house 73-288 (290) alignment 
Range on Protein: 146-361
Range on HMM: 73-288/290.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYD-AQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFN
 ||||||||||| .|.| | ||.|||. |..|| .|||||||| .   |||| |.  .|  |.... | ..|...|..|.... |.|.|||.| ......
nylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtld

QFSVFKRPLEIPDVGVLTDLTWADPDpTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFS
.   ..|  |.|. | |.|| |.|||   .|.  | ||| . ||    ..| |. .|....| ||.| .||..   |..|||||||||| .  | ||.. 
kiraldrlqevphegplcdllwsdpd.drggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaaile

IDKKLKISINVFRPESR
.|.||| |.. | | .|
lddklkysflqfdpapr
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 146-359 1.5e-65 214.1 In-house 72-289 (290) alignment 
Range on Protein: 146-359
Range on HMM: 72-289/290.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSFNQ
..||||||||||. |.|| .||  .|. |. ...||||||| | ||. |||. |.  . ...|.  .|..|. ...|| ... |.|||||||... |.. 
kflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkieswes

FSVFKRPLEI--PDVGVLTDLTWADPDP--TEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAA
.  .|.|      | |.  || ||||.   ..       |. | |||  .|  .|||| |....| |.| |.|..|   ..|||.|||| |.|.. |  |
lkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlga

VFSIDKKLKISINVFRPE
.  . . |..|| |..|.
iatvseslelsivvlkpr
subfamily_PPG1_pd Subfamily PPG1 146-357 9.7e-63 205.2 In-house 70-294 (300) alignment 
Range on Protein: 146-357
Range on HMM: 70-294/300.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRY--DAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
 ||||||||||| .|.| ..||..||| || || ||||||||| .  .|||| |.  .|  ...... . ..|. .  .|.|.. |.|.|||.|    | 
nylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsi

NQFSVFKRPLEIPDVGVLTDLTWADPD---------PTEKG--YKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNY
.|  |. |  |.|. | |.|| |.||.         | ..|  .. | ||| . .|      ||.. |.. .|| ||.. .||. .   .| |..|||||
dqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapny

CGQNDNTAAVFSIDKKLKISINVFR
| .  | |..  . .|..  .||. 
cyrcgnkasilelyekderyfnvye
subfamily_PPPLV_pd Subfamily PPPLV 146-349 9.6e-49 159.2 In-house 57-280 (290) alignment 
Range on Protein: 146-349
Range on HMM: 57-280/290.0
RYLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNYRYDAQL---YECFQNMFNVFPFCAVINNTIMCMHGGISEHLTS
 .||||||||||.||.|..  | |||. || ...||||||| .||  |. .. |  ...  .|   .| |.|.|...|  |||.....|.|.|| .   .
sllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimt

FNQFSVFKRPL-----EIPDVGVLTDLTWADPDPT-----------EKGYKP-SARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVT
  . |  .  |     .|    .  |. |.||.             ..|. . . || . ||.  || ||||. .|. |.| |.| | |...  . ||.|
qayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrllt

IFSAPNYCGQNdNTAAVFSIDKK-L
.||. .|||.  | ||.  .||| |
vfsssrycGss.neaalilvdkkkl
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 147-368 2.1e-57 187.7 In-house 77-301 (307) alignment 
Range on Protein: 147-368
Range on HMM: 77-301/307.0
YLFLGDYVDRGPFSMEVVILLTALKLAYPDRIYLLRGNHESRSVNTSYGFYREVNY---RYDAQLYECFQNMFNVFPFCAVINNTIMCMHGGISEHLTSF
|.| ||||||| .|.|...|| . |..||. | |||||||   ||  |||| |.     .   ...  ||  || .|  |.|   |.|||||.|  || .
yvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcl

NQFSVFKRPLEIPDVGVLTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVF
...    .|.  |  |.. |. ||||||.   .| |.||. | ||   .    |.| ....|| ||.. |||  . ||.|.|||||| ||    |. .|.
delrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvl

SIDKKLKISINVFRPESRDKKRGFE
 .|. | | .  | ||| . ..  |
kvdetlgiqlvafvpeseniekiie
subfamily_PPP7C_pd Subfamily PPP7C 261-360 1.7e-18 59.5 In-house 237-336 (383) alignment 
Range on Protein: 261-360
Range on HMM: 237-336/383.0
LTDLTWADPDPTEKGYKPSARGASFVFGPPALRAFLKKLDLQMVIRGHQVVEDGYEFFDGRRLVTIFSAPNYCGQNDNTAAVFSIDKKLKISINVFRPES
. |. |.||  .|     . ||.   |||   . .|.| .|...|| |.   .||||   ....||||| ||  .  |  |   . |.|.  |  .  ..
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqask